CN112755134A

CN112755134A - Plaster for treating hyperosteogeny and preparation method thereof

Info

Publication number: CN112755134A
Application number: CN202110184754.7A
Authority: CN
Inventors: 金孟杰
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-02-10
Filing date: 2021-02-10
Publication date: 2021-05-07
Anticipated expiration: 2041-02-10
Also published as: CN112755134B

Abstract

The invention discloses a plaster for treating hyperosteogeny and a preparation method thereof. The plaster is prepared from the following raw materials in parts by weight: 20-30 parts of lycoris radiate; 20-30 parts of bulbophyllum styracifolium; 20-30 parts of uncaria; 15-20 parts of gynostemma pentaphylla; 1-2 parts of borneol; 2-3 parts of acetic acid; 1-2 parts of white sugar; 2-3 parts of yellow wine. The ointment has simple formula, low cost and simple preparation method. The plaster for treating the hyperosteogeny has short treatment time, quick response and few side effects, and can soften the bony spur, promote blood circulation to stop pain, soften and atrophy the bony spur and prevent the bony spur from growing any more.

Description

Plaster for treating hyperosteogeny and preparation method thereof

Technical Field

The invention relates to the field of traditional Chinese medicines, in particular to a plaster for treating hyperosteogeny and a preparation method thereof.

Background

Hyperosteogeny is a frequently-occurring and common disease, generally occurs in middle-aged and elderly people, and is often caused by old and weak body, kidney deficiency, insufficient bone marrow, bone malnutrition, and in addition, weak body, insecurity of external defense, wind cold and dampness. The hyperosteogeny mainly occurs in the knee joints of the legs and knees, the heels, the hip joints, the waist, the cervical vertebra, the chest and the like, and most of the hyperosteogeny occurs in the cervical vertebra and the lumbar vertebra. The hyperosteogeny of the lumbar vertebra usually occurs in middle-aged years, the physiological functions of tissue cells of a body are gradually degenerated and aged along with the increase of the lumbar vertebra hyperosteogeny, the degenerated intervertebral disc gradually loses water, intervertebral space is narrowed, fiber rings are relaxed and bulge to the periphery, the vertebral body is unstable, the fiber rings are torn outside the edge of the vertebral body to cause the protrusion of nucleus pulposus, the periosteum of the posterior longitudinal ligament is jacked up, new bones are generated below the posterior longitudinal ligament, and bony spur or hyperosteogeny is formed; it is also considered that when a person stands or walks for a long time and holds a certain posture for a long time, the person forms spinous or labial hyperosteogeny due to muscle traction, avulsion, bleeding, and hematoma organization; the bone spur can cause mechanical stimulation to soft tissue and can be caused by soft tissue injury, bleeding and swelling after trauma. There are many methods for treating hyperosteogeny, and the following methods can be roughly used:

(1) physical therapy: the drug ions mainly enter into the skin through sweat gland catheter pores or enter into mucosal tissues through mucosa and epithelial cell gaps, the physiological treatment effect of the method is mainly determined by the pharmacological property of the introduced drug ions besides the current effect, the method gives full play to the effect of the drug, but the introduced drug is liquid, is volatile and has non-lasting drug effect, so the treatment effect of the method is limited.

(2) Massaging and traction: the massage is helpful for improving local blood circulation and has the functions of diminishing inflammation and relieving pain; traction can relieve local nerve and tissue compression caused by bony spur, and has temporary pain relieving effect. However, this method only has a temporary analgesic effect.

(3) Acupuncture and moxibustion: acupuncture and moxibustion can promote blood circulation to relieve pain and eliminate local edema and inflammation, but for hyperosteogeny, acupuncture and moxibustion can only play an auxiliary treatment role.

(4) Treatment with western medicines: at present, no effective treatment medicine for the disease exists in western medicine. Generally adopts symptomatic treatment, for example, some antipyretic and analgesic drugs can be taken when pains occur; the B vitamins can be selected for the numb patients; the joint swelling with effusion can be treated by local effusion extraction or local occlusion. However, practice proves that the treatment methods are not ideal, only treat the symptoms but not the root causes, and the disease condition is easy to relapse.

(5) And (3) surgical treatment: when conservative treatment is selected, the disease condition is serious and the life of a patient is seriously influenced, the operation treatment can be considered; but this method is not readily accepted by patients.

(6) The traditional Chinese medicine treatment comprises the following steps: because the disease belongs to frequently encountered diseases and common diseases, and western medicines have no ideal treatment method, the disease is treated by a large amount of Chinese traditional medicines in China in recent years, and great progress is made.

The traditional Chinese medicine for treating the hyperosteogeny comprises an internal medicine and an external medicine. The oral medicine is absorbed, digested and decomposed through intestines and stomach, and finally the medicine can be delivered to the local part through blood circulation, the whole process can reach the focus part through a layer of barrier, and the medicine effect is remained a little, so the effect is very slow and low-efficiency, the methods can only relieve the pain symptom in clinical application, the function rehabilitation is irreversible, the bone repair is silent, and the oral medicine has great damage to the liver, the kidney and the intestines and the stomach. The external medicine can overcome the defects, but the current external medicine for treating hyperosteogeny can not meet the requirements of patients. Patent document CN101530598A discloses a plaster for treating hyperosteogeny, which is prepared from the following raw materials in percentage by mass: 10-35 parts of angelica sinensis, 10-35 parts of salvia miltiorrhiza, 10-35 parts of frankincense, 10-35 parts of myrrh, 15-25 parts of radix stephaniae tetrandrae, 15-25 parts of rhizoma atractylodis, 15-25 parts of radix curcumae, 15-25 parts of cortex phellodendri, 15-25 parts of radix rehmanniae, 5-15 parts of rhizoma dioscoreae hypoglaucae, 10-20 parts of radix paeoniae alba, 10-20 parts of cassia twig, 10-15 parts of sappan wood, 15-25 parts of ramulus mori, 10-20 parts of herba lycopi, 5-15 parts of cortex acanthopanacis, 10-20 parts of radix linderae, 10-20 parts of pseudo-ginseng and 15-25 parts of fructus liquidambaris. The plaster has complicated formulation and high cost. Patent document CN1329897A discloses an anti-hyperosteogeny drug and a preparation method thereof, wherein the formula comprises the following components in parts by weight: masson pine endothelium 90-220; 5-15 parts of raw masson pine oil; 10-35 parts of eucommia ulmoides oliv; 5-10 parts of dry ginger; 30-70 parts of realgar; 2-10 parts of arsenic; and 8-20 parts of lycoris radiata. The medicine has simple formula, but has complex preparation process and uses poisonous substance arsenic. In conclusion, for hyperosteogeny, the external ointment with simple formula, short treatment time, low cost and quick response is still lacked at present.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides a plaster for treating hyperosteogeny and a preparation method thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

a plaster for treating hyperosteogeny is prepared from the following raw materials in parts by weight:

20-30 parts of lycoris radiate; 20-30 parts of bulbophyllum styracifolium; 20-30 parts of uncaria; 15-20 parts of gynostemma pentaphylla; 1-2 parts of borneol; 2-3 parts of acetic acid; 1-2 parts of white sugar; 2-3 parts of yellow wine.

The raw materials of the medicinal materials are as follows:

bulbus Lycoridis Radiatae (L' Her.) Herb) with bulb as medicinal part, collecting, cleaning, and drying in the shade; producing areas such as Shandong and Henan; according to the record of Chinese plant official gazette, the lycoris radiata bulb contains more than ten kinds of alkaloids such as lycorine, pseudolycorine, narcissus pseudonarcissus, lycoramine, galanthamine and the like; has effects in clearing away toxic materials, eliminating phlegm, promoting urination, promoting vomiting, and killing parasite; can be used for treating sore throat, carbuncle, sore, scrofula, nephritis, edema, and snake bite; lycorine has anticancer activity, and has antiinflammatory, antipyretic, tranquilizing and emetic effects.

Dioscorea bulbifera L, also called Dioscorea bulbifera and Longhairy antenoron, is the dried tuber of Dioscorea bulbifera L. Mainly distributed in Sichuan, Yunnan and Guizhou provinces. According to the record of Chinese medicine dictionary: dioscorea bulbifera has the effects of cooling blood, lowering fire, eliminating goiter and detoxifying, and can be used for hematemesis, epistaxis, throat impediment, goiter, sore and carbuncle scrofula.

Ramulus Uncariae cum uncis, dried stem with hook of Uncaria gambir Uncaria rhynchophylla (Miq.) Miq.ex Havil.of Rubiaceae, Uncaria macrophylla wall.of Uncaria macrophylla, Uncaria hirsuta Havil.of Uncaria gambir (Oliv.) Uncaria or Uncaria cannatis sessile fruits Roxb.; the producing area is Shandong, Henan, etc., and the medicinal part is stem branch with hook; according to the record of Chinese pharmacopoeia (2015 edition), the functions and indications are as follows: has effects in clearing away heat, arresting convulsion, lowering blood pressure, dispelling pathogenic wind, removing dampness, and calming liver; can be used for treating stirring of liver-wind, convulsion, febrile convulsion, common cold with convulsion, infantile cry, eclampsia in pregnancy, headache, and vertigo.

Gynostemma pentaphylla (known by the scientific name: Gynostemma pentaphylum (Thunb.) Makino), the medicinal part is the whole herb of the Cucurbitaceae plant Gynostemma pentaphylla, and the production places are Anhui, Zhejiang and the like. According to Chinese plant record, the Chinese herbal medicine composition has the effects of tonifying qi and spleen, eliminating phlegm and stopping cough, and clearing away heat and toxic materials; the main treatment is as follows: asthenia; consumptive disease and loss of essence; leukopenia; hyperlipidemia; viral hepatitis; chronic gastroenteritis; chronic tracheitis.

Borneol, recorded in the chinese pharmacopoeia (2015 edition), has the following functions and indications: inducing resuscitation and refreshing mind, clearing heat and relieving pain; can be used for treating fever unconsciousness, convulsion, apoplexy with phlegm syncope, qi stagnation and sudden syncope, central nausea and coma, thoracic obstruction, cardialgia, conjunctival congestion, aphtha, sore throat, and purulence in ear canal.

The acetic acid is acetic acid solution with acetic acid content of 3-7g/100mL, preferably acetic acid or grain brewing vinegar with acetic acid content of 3-5g/100mL, such as old vinegar or rice vinegar brewed by glutinous rice, sorghum and the like.

The white sugar can be any commercially available white sugar.

Yellow wine, the yellow wine of the invention can be commercially available yellow wine, such as Shaoxing yellow wine, preferably yellow wine brewed by yeast with 14-20% of alcohol content. The yellow wine is rich in nutrition and contains various amino acids.

The Chinese medicinal raw materials of the invention can be specifically introduced in Chinese pharmacopoeia (2015 edition), Chinese medicinal dictionary, Chinese plant record and the like.

As a preferred embodiment, the plaster for treating hyperosteogeny is prepared from the following raw materials in parts by weight:

23-27 parts of lycoris radiata; 23-27 parts of bulbophyllum styracifolium; 23-27 parts of uncaria; 16-18 parts of gynostemma pentaphylla; 1 part of borneol; 2-3 parts of acetic acid; 1 part of white sugar; 2-3 parts of yellow wine.

25 parts of lycoris radiate; 25 parts of bulbophyllum xanthocarpum; 25 parts of uncaria; 17.5 parts of gynostemma pentaphylla; 1 part of borneol; 2.5 parts of acetic acid; 1 part of white sugar; 2.5 parts of yellow wine.

The above plaster for treating hyperosteogeny, as a preferred embodiment, may further comprise a skin penetrating agent.

The medicine principle of the invention is as follows:

the lycoris radiata, the bulbophyllum flaccidum, the uncaria rhynchophylla and the gynostemma pentaphylla all have the effects of clearing away heat and toxic materials, inducing diuresis and reducing edema, the borneol also has a certain effect of clearing away heat and relieving pain, the white vinegar, the yellow wine and the white sugar are used as primers to increase the anti-inflammatory, heat-clearing and detoxifying effects of the lycoris radiata, the bulbus flaviperis, the uncaria rhynchophylla and the gynostemma pentaphylla, and the lycoris radiata, the bulbus flaviperis, the uncaria rhynchop.

The preparation method of the plaster for treating hyperosteogeny comprises the following steps:

processing Bulbus Lycoridis Radiatae, radix Dioscorea Bulbiferae, ramulus Uncariae cum uncis, and herba Gynostemmatis into powder; then mixing the powder with borneol, acetic acid, white sugar and yellow wine according to the proportion, adding a proper amount of water, boiling with strong fire, turning to small fire or boiling with slow fire to obtain a paste, and obtaining the paste, namely the plaster for treating the hyperosteogeny.

The strong fire in the invention is the strong fire in the field of traditional Chinese medicine decoction, and can quickly heat the liquid medicine to be violently boiled.

In the invention, the small fire can keep the liquid medicine slightly boiling, namely the liquid medicine is kept above 100 ℃, such as 100-105 ℃.

In the above preparation method, as a preferred embodiment, the addition of an appropriate amount of water means that the amount of water added is 5 to 20 times, preferably 10 to 15 times, the mass of all the raw materials (i.e., lycoris radiata, bulbus dioscoreae, uncaria, gynostemma pentaphylla, borneol, acetic acid, white sugar and yellow wine).

In the above preparation method, as a preferred embodiment, it further comprises adding a skin penetrating agent to the obtained paste and mixing uniformly to obtain the plaster for treating hyperosteogeny, wherein the amount of the skin penetrating agent added is 1-4% of the mass of the paste. That is, the cream is preferably added with a skin penetrating agent in an amount of 1-4% by mass of the cream before use as the plaster of the present invention to enhance the drug penetration ability, and is used in the following manner after being uniformly stirred. The skin penetrating agent can be topical medicine or skin care product common penetrating agent, such as laurocapram, dimethyl isosorbide, inositol, etc.

The plaster can be prepared into a sticky plaster for convenient application, for example, the plaster is arranged on gauze and then fixed on a part needing to be treated by a medical adhesive plaster; preferably, the plaster is applied to the affected part with gauze when the pasty medicine is warm (such as 30-37 deg.C), water can not be seen within 2 days after each application, a new plaster is taken off after 2 days, the dosage of the plaster at each part is 60-120g, the plaster is taken 10 times in each treatment course, the bony spur can be softened after 1-3 treatment courses, the pain of the hyperplastic part disappears, and the hyperplastic part is not easy to recur, thereby achieving the treatment effect.

Compared with the prior art, the invention has the following beneficial effects:

1) the ointment has simple formula, low cost and simple preparation method.

2) The plaster is used for treating hyperosteogeny, and has the advantages of short treatment time, quick response and little side effect.

3) The plaster has effects of softening bony spur, promoting blood circulation, relieving pain, and preventing bony spur from shrinking and growing.

Drawings

Fig. 1 shows the CR image examination results of the left knee joint of case 1 before and after treatment with the plaster of this example 1, wherein fig. 1(a) shows before treatment and fig. 1(b) shows after treatment.

Fig. 2 shows the CR image examination results of the lumbar vertebrae of case 2 before and after treatment with the plaster of example 1, wherein fig. 2(a) is before treatment and fig. 2(b) is after treatment.

Fig. 3 shows the CR image examination results of the right knee joint of case 3 before and after treatment with the plaster of example 1, wherein fig. 3(a) shows before treatment and fig. 3(b) shows after treatment.

Fig. 4 shows the CR image examination results of the left calcaneus of case 4 before and after treatment with the plaster of example 1, wherein fig. 4(a) is before treatment and fig. 4(b) is after treatment.

Fig. 5 shows the CR image examination results of case 5 before and after treatment of cervical vertebrae with the plaster of this example 1, wherein fig. 5(a) is before treatment and fig. 5(b) is after treatment.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be further described in detail with reference to the accompanying drawings and embodiments. It should be understood that these examples are only for illustrating the present invention and are not intended to limit the scope of the present invention; after reading the present disclosure, various changes or modifications may be made by those skilled in the art, and equivalents may fall within the scope of the invention as defined by the appended claims.

The acetic acid used in the embodiment of the invention is mature vinegar with the acetic acid content of 5g/100mL, and the yellow wine is Shaoxing yellow wine with the alcohol degree of 15% (vol).

Example 1

50g of lycoris radiate; 50g of radix dioscoreae; 50g of uncaria; 35g of gynostemma pentaphylla; 2g of borneol; 5g of acetic acid; 2g of white sugar; 5g of yellow wine.

The preparation method of the plaster comprises the following steps: processing Bulbus Lycoridis Radiatae, radix Dioscorea Bulbiferae, ramulus Uncariae cum uncis and herba Gynostemmatis into powder respectively, adding the powder, Borneolum Syntheticum, acetic acid, white sugar and yellow wine into 1200g of water according to the above dosage, mixing well, boiling with strong fire, turning to slow fire to keep boiling slightly until it is decocted into paste (paste water content is lower than 20%), dividing the paste into three times; after the ointment is cooled to a temperature acceptable to the skin, the ointment is applied to the affected part by gauze, the affected part can not see water within 2 days, a new ointment is removed after 2 days, 3 parts of the ointment are used up, and then the ointment is prepared again, wherein 10 times of associated use is a treatment course. Whether two treatment courses are continuously used or not can be considered according to the disease condition degree, for patients with less than moderate hyperosteogeny, the effect of softening the bony spur and even slightly reducing the bony spur can be achieved by 2 to 3 treatment courses, and the clinical symptoms of the hyperosteogeny basically disappear or completely disappear.

Example 2

lycoris 60 g; 60g of radix dioscoreae; 60g of uncaria; 40g of gynostemma pentaphylla; 2g of borneol; 6g of acetic acid; 2g of white sugar; 6g of yellow wine.

The preparation method of the plaster comprises the following steps: respectively processing lycoris radiata, bulbophyllum xanthocarpum, uncaria rhynchophylla and gynostemma pentaphylla into powder, adding the powder, borneol, acetic acid, white sugar and yellow wine into 2000g of water according to the above dosage, uniformly mixing, boiling with strong fire, turning to small fire to keep slight boiling until the mixture is decocted into paste, and uniformly dividing the paste into three times for use; after the ointment is cooled to a temperature acceptable to the skin, the ointment is applied to the affected part by gauze, the affected part can not see water within 2 days, a new ointment is removed after 2 days, 3 parts of the ointment are used up, and then the ointment is prepared again, wherein 10 times of associated use is a treatment course. Whether two treatment courses are continuously used or not can be considered according to the disease condition degree, for patients with less than moderate hyperosteogeny, the effect of softening the bony spur and even slightly reducing the bony spur can be achieved by 2 to 3 treatment courses, and the clinical symptoms of the hyperosteogeny basically disappear or completely disappear. For moderate and severe patients with slow hyperosteogeny, the treatment course can be increased, and the medicine also has the functions of softening the bony spur, reducing the bony spur, relieving pain and even eliminating the pain.

Comparative example

The plaster of the comparative example is prepared from the following raw materials in parts by weight:

lycoris 60 g; 70g of radix dioscoreae; 65g of uncaria; 2g of borneol; 5g of acetic acid; 2g of white sugar; 5g of yellow wine.

The preparation and application of the comparative plaster were the same as in example 1.

The clinical data of the plaster of the invention

The inventor has already carried out clinical observation and treatment on hundreds of patients with hyperosteogeny at different parts in recent 5 years, the ages of the patients with hyperosteogeny are mostly distributed over 50 years, the patients are confirmed to be moderate and severe hyperosteogeny patients according to the medical history, physical signs and X-ray examination, and the parts with hyperosteogeny comprise knee joints, heels, cervical vertebrae, lumbar vertebrae and the like.

Before the plaster is used for treatment of each case, western medicines such as meloxicam and fenbidon are basically used for resisting inflammation and relieving pain, and medicines for nourishing cartilage such as glucosamine hydrochloride capsules or glucosamine sulfate capsules are also taken by people for a long time. These drugs either have a poor or slow analgesic effect or are prone to relapse after withdrawal. However, after the plaster is used for treating patients by external application for 1 to 3 courses of treatment, the clinical symptoms are basically well controlled, the pain basically disappears, and the diseases are not easy to relapse.

To further illustrate the therapeutic effect of the plasters of the present invention, the specific therapeutic effect results of 200 cases are shown in Table 1 below. In 200 cases, patients under 50 years of age or over 80 years of age were excluded, excluding patients with other diseases that may cause pain at the treatment site.

200 cases included: 105 knee joint hyperosteogeny patients; 43 patients with lumbar hyperplasia; 52 cases of cervical hyperplasia patients.

The medication method comprises the following steps: the plaster prepared by the method of the embodiment 1 of the invention is used for external application treatment, and other medicines for oral administration or external application are not used in the period. When the plaster is warm (such as 30-37 deg.C), gauze is applied to affected part, water can not be seen within 2 days after application, a new plaster is removed, the dosage of plaster per part is about 100g, and 10 times of plaster per treatment course for 2 treatment courses.

The curative effect standard is as follows:

the clinical cure is as follows: clinical symptoms disappear, local movement is free, normal work is recovered, the hyperosteogeny is not increased after the CR image review, and the relapse does not occur after 1 year follow-up.

The effect is shown: the clinical symptoms basically disappear, and the local activity is not obviously limited.

The method has the following advantages: the clinical symptoms are obviously improved, and the symptoms can appear after fatigue or cold, but are relieved compared with the prior symptoms.

And (4) invalidation: after 2-3 courses of treatment, the clinical symptoms are not obviously improved, and the joint movement disorder is not changed or even aggravated.

After 2 courses of treatment, the effect statistics were as follows:

of 105 knee joint hyperosteogeny patients, 58 patients were cured clinically, 30 patients were effective, 14 patients were effective, and 3 patients were ineffective;

of 43 patients with lumbar hyperplasia, 25 patients were cured clinically, 14 patients were effective, 4 patients were effective, and 0 patient was not effective;

of the 52 patients with cervical vertebra hyperplasia, 32 patients were cured clinically, 14 patients were effective, 5 patients were effective, and 1 patient was ineffective.

TABLE 1 statistics of the therapeutic effect of the plaster of the invention

Item	Recovery method	Show effect	Is effective	Invalidation
					Number of people	115	58	23	4
Ratio of occupation of	57.5％	29％	11.5％	2％

As can be seen from the statistical results in Table 1, the total effective rate of the plaster of the present invention is 98%.

Comparative example plaster clinical data

In the research stage of the plaster raw material formula of the invention, the inventor also tries to externally apply the plaster prepared by the raw material formula of the comparative example to part of patients for treatment, but the plaster obtained by the comparative example has poor treatment effect compared with the plaster of the invention, the comparative example plaster is used on 20 patients with moderate hyperosteogeny, including 12 patients with knee joint hyperosteogeny, 3 patients with lumbar vertebra hyperplasia and 5 patients with cervical vertebra hyperplasia, 20 patients with moderate hyperosteogeny do not include patients with the age less than 50 years old or the age more than 80 years old, and patients with other diseases which can cause pain at the treatment part are excluded. The method of application of the plaster of the present invention is the same as the method of application of the plaster of the present invention. The specific efficacy statistics are given in table 2 below.

After 2 courses of treatment, the effect statistics were as follows:

of 12 knee joint hyperosteogeny patients, 1 patient is cured clinically, 6 patients are effective, 4 patients are effective, and 1 patient is ineffective;

of 3 patients with lumbar vertebra hyperplasia, 0 patient is cured clinically, 2 patients are effective, 1 patient is effective, and 0 patient is ineffective;

of 5 patients with cervical vertebra hyperplasia, 0 patients were cured clinically, 3 patients were effective, 2 patients were effective, and 0 patients were ineffective.

Table 2 statistics of the therapeutic effect of the comparative example plasters

Item	Recovery method	Show effect	Is effective	Invalidation
					Number of people	1	11	7	1
Ratio of occupation of	5％	55％	35％	5％

As can be seen from the statistical results in Table 2, the total effective rate of the plaster of the comparative example is 95%. Although the total effective rate is not too low, the cure rate is too low, and the disease is easy to relapse.

Clinical typical cases of the plaster of the invention

The following cases are moderate and severe cases diagnosed in a regular hospital, and before the plaster is used for treatment, the pain is relieved after taking the plaster, but the pain recurs in the half year after stopping taking the plaster.

Case 1: if 67 years old female in Qian has degenerative change of both knees, the left knee cannot bend normally and walking is difficult. 2019-03-29CR image examination of the right side position of the left knee joint shows that: the knee joints are regularly arranged, so that hyperosteogeny and joint gaps are narrowed. Impression: the left knee joint degenerates, and the image is shown in fig. 1 (a).

2019-03-29CR image examination, and then the plaster prepared by the method of the embodiment 1 of the invention is used for external application treatment on the next day, and other medicines for oral administration or external application are not used in the treatment period. When the plaster is warm (such as 30-37 ℃), gauze is applied to the affected part, water cannot be seen within 2 days after each application, a new plaster is taken off after 2 days, the dosage of the plaster at each part is about 100g, the plaster is taken off 10 times in each treatment course, after 3 treatment courses, pain at the hyperplasia part disappears, the left knee can be bent normally, and the patient can walk normally. When the plaster is stopped for 1 month, the patient is rechecked in 2019-06-28, the image picture is shown in fig. 1(b), and compared with the CR image examination result of 2019-03-29, the plaster has no larger or slightly smaller bony spur, which shows that the plaster has softening effect on the bony spur and has good treatment effect. The patients follow up after one year, and the pain of the patients does not relapse within more than one year, which indicates that the plaster is not easy to relapse after treatment.

Case 2: a58-year-old female has serious lumbar pain and affects normal life. 2019-06-13CR images are used for checking the positive side position of the lumbar vertebra, and the images show that the lumbar vertebra body has hyperosteogeny and the physiological curvature is straightened. Impression: the lumbar vertebra degenerates, and the image picture is shown in fig. 2 (a).

2019-06-13CR image examination, and then starting the plaster prepared by the method of the invention in the embodiment 1 for external application treatment, wherein other medicines for oral administration or external application are not used in the treatment period. When the plaster is warm (such as 30-37 ℃), gauze is applied to the affected part, water cannot be seen within 2 days after each application, a new plaster is removed after 2 days, the dosage of the plaster at each part is about 100g, the plaster is used for 10 times in each treatment course, after 1 half treatment course, the pain caused by lumbar hyperplasia basically disappears, and the patient is reviewed in 2019-07-15, and the picture is shown in fig. 2 (b). Compared with the CR image examination result of 2019-06-13, the plaster has no enlarged bone spur, which shows that the plaster has a softening effect on the bone spur and has a good treatment effect. The patients follow up after one year, and the pain of the patients does not relapse within one year, which shows that the plaster is not easy to relapse after treatment.

Case 3: the fur and Yao 66 year old man has severe pain in the right knee joint and affects normal walking. 2019-10-10CR images are used for checking the right side position of the right knee joint, and the images show that the morphological structure of the right knee joint is intact, the tibial plateau, the lower end of the tibia and the edge of the patella have hyperosteogeny, and the joint clearance is narrowed. Impression: the image of the right knee joint with hyperosteogeny is shown in fig. 3 (a).

2019-10-10CR image examination, and starting the plaster prepared by the method of the embodiment 1 of the invention on the next day after the examination, wherein other medicines for oral administration or external application are not used in the treatment period. When the plaster is warm (such as 30-37 ℃), gauze is applied to an affected part, water cannot be seen within 2 days after the plaster is applied every time, a new plaster is taken off after 2 days, the dosage of the plaster at each part is about 100g every time, the plaster is taken for 10 times in each treatment course, after 3 treatment courses, pain caused by hyperplasia of the right knee joint completely disappears, a patient is reviewed in 2019-12-10, and a picture is shown in fig. 3(b), and the image shows that: the right knee joint has regular arrangement of bones, hyperosteogeny and narrowed joint space, but the bony spur is not enlarged and looks slightly smaller. The plaster has the function of softening the bony spur and has good treatment effect. The patients follow up after one year, and the pain of the patients does not relapse within one year, which shows that the plaster is not easy to relapse after treatment.

Case 4: a male aged 71 years old with pain in the left heel affects normal walking. 2019-07-29CR image examination of lateral position and axial position of left calcaneus shows that hyperosteogeny is seen at the lower part of the left calcaneus, and the image picture is shown in figure 4 (a).

2019-07-29 on the next day after the CR image examination, the plaster prepared by the method of the embodiment 1 of the invention is used for external application treatment, and other medicines for oral administration or external application are not used in the treatment period. When the plaster is warm (such as 30-37 ℃), gauze is applied to an affected part, water cannot be seen within 2 days after the plaster is applied every time, a new plaster is removed after 2 days, the dosage of the plaster at each part is about 100g every time, the plaster is used for 10 times in each treatment course, after 3 treatment courses, the pain completely disappears, a patient is reviewed in 2019-09-29, an image picture is shown in fig. 4(b), the lateral position and the axial position of the left calcaneus are examined by a CR image, the image shows that the lower edge of the left calcaneus is in hyperosteogeny, no obvious damage symptom is seen, and the hyperosteogeny is not enlarged. The plaster has the function of softening the bony spur and has good treatment effect. The patients follow up after one year, and the pain of the patients does not relapse within one year, which shows that the plaster is not easy to relapse after treatment.

Case 5: a male 50 years old wears the pillow and has cervical pain and arm numbness. 2019-08-24CR images are used for inspecting the positive side position of the cervical vertebra, and the images show that the physiological curvature of the cervical vertebra exists, the edge of the cervical vertebra body has hyperosteogeny change, the hook of the vertebra body has a tip, and the intervertebral space does not have narrowing. Impression: cervical vertebra hyperosteogeny, see picture 5 (a).

2019-08-24CR image examination, and then the plaster prepared by the method of the invention in the embodiment 1 is used for external application treatment, and other medicines for oral administration or external application are not used in the treatment period. When the plaster is warm (such as 30-37 ℃), gauze is applied to an affected part, water cannot be seen within 2 days after the plaster is applied every time, a new plaster is removed and replaced after 2 days, the dosage of the plaster at each part is about 100g every time, the plaster is used for 10 times in each treatment course, after treatment of 2 treatment courses, cervical vertebra pain and arm tingling symptoms completely disappear, a patient is reviewed in 2019-09-30, an image picture is shown in figure 5(b), the positive side of the cervical vertebra is checked by a CR image, the image shows that physiological curvature of the cervical vertebra exists, part of cervical vertebra edge bone hyperplasia exists, and bone spurs do not grow. The plaster has the function of softening the bony spur and has good treatment effect. The patients follow up after one year, and the pain of the patients does not relapse within one year, which shows that the plaster is not easy to relapse after treatment.

The comparison of the treatment front and the treatment back of the above cases shows that the bony spur is not enlarged, the external application treatment of the medicine of the invention controls the bony spur, the bony spur of some patients is slightly reduced after 1-2 months of treatment from the light sheets of the comparison front and back, and the pain part of the patient himself has no obvious pain, which indicates that the state of the severe pain caused by the hard friction of the bony spur is changed into the soft state without causing the pain of the patient.

In conclusion, the plaster for treating the hyperosteogeny provided by the invention has the advantages of simple formula and low cost; the preparation method and the application method are simple, the treatment time is short, and the effect is quick. The invention obtains satisfactory trial effect through repeated test verification.

Claims

1. A plaster for treating hyperosteogeny is characterized in that the raw materials for preparing the plaster comprise, by weight:

2. The plaster for treating hyperosteogeny according to claim 1, wherein the raw materials for preparing the plaster comprise, in parts by weight:

3. The plaster for treating hyperosteogeny according to claim 2, wherein the raw materials for preparing the plaster comprise, by weight:

4. A plaster for use in the treatment of hyperosteogeny according to any one of claims 1 to 3, further comprising a skin penetrating agent.

5. A process for preparing a plaster for the treatment of hyperosteogeny according to any one of claims 1 to 4, comprising the steps of:

processing Bulbus Lycoridis Radiatae, radix Dioscorea Bulbiferae, ramulus Uncariae cum uncis, and herba Gynostemmatis into powder; then mixing the powder with borneol, acetic acid, white sugar and yellow wine according to the raw material proportion of claims 1-4, adding a proper amount of water, boiling with strong fire, turning to small fire or boiling with slow fire to form a paste, and obtaining the paste as the plaster for treating hyperosteogeny.

6. The preparation method according to claim 5, wherein the adding of the proper amount of water is 5-20 times of the total mass of the raw materials comprising lycoris radiata, bulbus dioscoreae bulbiferae, uncaria rhynchophylla, gynostemma pentaphylla, borneol, acetic acid, white sugar and yellow wine.

7. The preparation method of claim 6, wherein the adding of the proper amount of water is 10-15 times of the total mass of the raw materials comprising lycoris radiata, bulbus dioscoreae bulbiferae, uncaria rhynchophylla, gynostemma pentaphylla, borneol, acetic acid, white sugar and yellow wine.

8. The preparation method according to claim 5, further comprising adding a skin penetrating agent to the obtained paste and mixing uniformly to obtain the plaster for treating hyperosteogeny, wherein the amount of the skin penetrating agent added is 1-4% of the mass of the paste.