CN104800443A - Bone setting agent with functions of tonifying kidney and regenerating bone marrow - Google Patents
Bone setting agent with functions of tonifying kidney and regenerating bone marrow Download PDFInfo
- Publication number
- CN104800443A CN104800443A CN201510167338.0A CN201510167338A CN104800443A CN 104800443 A CN104800443 A CN 104800443A CN 201510167338 A CN201510167338 A CN 201510167338A CN 104800443 A CN104800443 A CN 104800443A
- Authority
- CN
- China
- Prior art keywords
- radix
- bone
- kidney
- rhizoma
- tonifying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 23
- 210000003734 kidney Anatomy 0.000 title claims abstract description 23
- 210000001185 bone marrow Anatomy 0.000 title claims abstract description 17
- 230000001172 regenerating effect Effects 0.000 title abstract 2
- 208000010392 Bone Fractures Diseases 0.000 claims abstract description 38
- 239000003814 drug Substances 0.000 claims abstract description 30
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 17
- 239000004863 Frankincense Substances 0.000 claims abstract description 14
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229940079593 drug Drugs 0.000 claims description 14
- 241000717739 Boswellia sacra Species 0.000 claims description 13
- 241001489978 Eupolyphaga Species 0.000 claims description 13
- 241000628997 Flos Species 0.000 claims description 13
- 239000009636 Huang Qi Substances 0.000 claims description 13
- 241001057584 Myrrha Species 0.000 claims description 13
- 210000000582 semen Anatomy 0.000 claims description 13
- 230000000694 effects Effects 0.000 abstract description 26
- 206010017076 Fracture Diseases 0.000 abstract description 22
- 208000002193 Pain Diseases 0.000 abstract description 14
- 230000036407 pain Effects 0.000 abstract description 13
- 206010020649 Hyperkeratosis Diseases 0.000 abstract description 7
- 210000004185 liver Anatomy 0.000 abstract description 5
- 230000035876 healing Effects 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 3
- 210000002805 bone matrix Anatomy 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 abstract description 2
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 2
- 210000000963 osteoblast Anatomy 0.000 abstract 2
- 235000013291 Alisma plantago aquatica Nutrition 0.000 abstract 1
- 240000004615 Alisma plantago-aquatica Species 0.000 abstract 1
- 241001254604 Angelica pubescens Species 0.000 abstract 1
- 241000382455 Angelica sinensis Species 0.000 abstract 1
- 241001061264 Astragalus Species 0.000 abstract 1
- 235000003717 Boswellia sacra Nutrition 0.000 abstract 1
- 240000007551 Boswellia serrata Species 0.000 abstract 1
- 235000012035 Boswellia serrata Nutrition 0.000 abstract 1
- 241000131329 Carabidae Species 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 240000007311 Commiphora myrrha Species 0.000 abstract 1
- 235000006965 Commiphora myrrha Nutrition 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 241000207901 Cuscuta Species 0.000 abstract 1
- 241000514824 Cyathula officinalis Species 0.000 abstract 1
- 241001148783 Davallia mariesii Species 0.000 abstract 1
- 241000123586 Dipsacaceae Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 241000112528 Ligusticum striatum Species 0.000 abstract 1
- 241000729196 Lycopus lucidus Species 0.000 abstract 1
- 235000007265 Myrrhis odorata Nutrition 0.000 abstract 1
- 241000304195 Salvia miltiorrhiza Species 0.000 abstract 1
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 abstract 1
- 240000006079 Schisandra chinensis Species 0.000 abstract 1
- 235000008422 Schisandra chinensis Nutrition 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 239000003124 biologic agent Substances 0.000 abstract 1
- 230000002308 calcification Effects 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 230000002787 reinforcement Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 210000004233 talus Anatomy 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 description 32
- 239000008280 blood Substances 0.000 description 13
- 210000004369 blood Anatomy 0.000 description 13
- 208000027418 Wounds and injury Diseases 0.000 description 8
- 230000017531 blood circulation Effects 0.000 description 8
- 230000001737 promoting effect Effects 0.000 description 8
- 206010052428 Wound Diseases 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 208000014674 injury Diseases 0.000 description 5
- 238000011084 recovery Methods 0.000 description 5
- 230000007812 deficiency Effects 0.000 description 4
- 208000006820 Arthralgia Diseases 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000005906 menstruation Effects 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000012913 prioritisation Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 208000024779 Comminuted Fractures Diseases 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010017081 Fracture delayed union Diseases 0.000 description 1
- 206010018852 Haematoma Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 208000032912 Local swelling Diseases 0.000 description 1
- 241000590428 Panacea Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241000219000 Populus Species 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 238000002266 amputation Methods 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000002180 anti-stress Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000009519 contusion Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000003748 differential diagnosis Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 210000000537 nasal bone Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000001582 osteoblastic effect Effects 0.000 description 1
- 210000004417 patella Anatomy 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a bone setting agent which has functions of tonifying kidney and regenerating bone marrow and is capable of accelerating fracture healing. The bone setting agent is prepared from active pharmaceutical ingredients in parts by weight as follows: 45-55 g of native copper, 12-18 g of davallia mariesii, 10-15 g of dipsacaceae, 10-15 g of cuscuta, 10-15 g of schisandra chinensis, 12-18 g of cyathula officinalis, 12-18 g of salvia miltiorrhiza, 12-18 g of caulis spatholobi, 12-18 g of ground beetles, 10-15 g of frankincense, 10-15 g of myrrh, 10-15 g of carthamus tinctorius, 10-15 g of angelica sinensis, 25-35 g of astragalus, 12-18 g of radix paeoniae alba, 10-15 g of alisma plantago-aquatica, 10-15 g of a hiraute shiny bugleweed herb, 10-15 g of pubescent angelica root, 10-15 g of ligusticum wallichii and 8-10 g of liquorice. The active pharmaceutical ingredients are decocted in water for oral dose; the agent treats both symptoms and root causes through synergistic effect of the traditional Chinese medicine through reasonable compatibility, can promote callus growth through adjustment and reinforcement of liver and kidney, improve the activity of osteoblasts, increase the quantity of the osteoblasts, promote calcification of the bone matrix and accelerate callus transformation, can further relieve local pain, and has more advantages than pure compounds and biological agents.
Description
Technical field
The invention belongs to technical field of Chinese medicines, specifically a kind of tonifying the kidney to regenerate bone marrow symplectic bone agent of accelerating union of bone fracture.
Background technology
Wound violence, contingency, the general wound that traumatic injury causes is common clinical frequently-occurring disease, severe trauma is threat to life not only, and rehabilitation course with the passing of time, the many complication of normal appearance and sequela, have a strong impact on quality of life, clinical treatment is intricate, therefore in wound middle and late stage recovery process, in the course of disease, normal appearance fracture does not connect, wound repeated infection disunion, soft tissue contusion does not recover, local hematoma difficulty absorbs, treatment of traumatic pain and dysfunction etc., differential diagnosis in tcm belongs to deficiency of the liver and kindey, stagnation of QI blood is tired, muscles and bones is lost and is supported in honor, noxious dampness is detained and is not gone.
Fresh fracture, old fracture, the Therapeutic Method of fracture delayed union and disunion is a lot, corresponding medicine is also a lot, except the most basic reduction of the fracture, fixing, outside the large principle of functional exercise three, separately there is traction therapeutic, Boards wall, plaster fixing, sizable delayed union and bone does not connect that fracture occurs than regular meeting is still had after tool braking and various operative treatment fracture, also can occur again to misplace or disunion because of the activity of patient between treatment and healing stage, even deformity causes amputation, inevitable massive losses is brought to the life of patient, also be that society increases certain burden simultaneously.
Motherland's medical science is thought, the kidney generating marrow and dominating bone, and the growth promoter of skeleton is all relevant with kidney.Traumatic injury, local swelling are meaning stagnation of QI blood, stagnation of QI and blood may bring about pain.
Summary of the invention
The object of the present invention, is the deficiency overcoming existing above-mentioned technology, provides a kind of tonifying the kidney to regenerate bone marrow symplectic bone agent of accelerating union of bone fracture.
For solving the problem, the technical solution adopted in the present invention is:
A tonifying the kidney to regenerate bone marrow symplectic bone agent for accelerating union of bone fracture, is made up of the crude drug of following parts by weight: Pyritum 45-55g, Rhizoma Drynariae 12-18g, Radix Dipsaci 10-15g, Semen Cuscutae 10-15g, Fructus Schisandrae Chinensis 10-15g, Radix Cyathulae 12-18g, Radix Salviae Miltiorrhizae 12-18g, Caulis Spatholobi 12-18g, eupolyphaga 12-18g, Olibanum 10-15g, Myrrha 10-15g, Flos Carthami 10-15g, Radix Angelicae Sinensis 10-15g, Radix Astragali 25-35g, Radix Paeoniae Alba 12-18g, Rhizoma Alismatis 10-15g, Herba Lycopi 10-15g, Radix Angelicae Pubescentis 10-15g, Rhizoma Chuanxiong 10-15g, Radix Glycyrrhizae 8-10g, is decocted in water for oral dose.
Below the further optimization of the present invention to such scheme:
A tonifying the kidney to regenerate bone marrow symplectic bone agent for accelerating union of bone fracture, is made up of the crude drug of following parts by weight: Pyritum 50g, Rhizoma Drynariae 15g, Radix Dipsaci 12g, Semen Cuscutae 12g, Fructus Schisandrae Chinensis 12g, Radix Cyathulae 15g, Radix Salviae Miltiorrhizae 15g, Caulis Spatholobi 15g, eupolyphaga 15g, Olibanum 12g, Myrrha 12g, Flos Carthami 12g, Radix Angelicae Sinensis 12g, Radix Astragali 30g, Radix Paeoniae Alba 15g, Rhizoma Alismatis 12g, Herba Lycopi 12g, Radix Angelicae Pubescentis 12g, Rhizoma Chuanxiong 12g, Radix Glycyrrhizae 9g, is decocted in water for oral dose.
Another kind of prioritization scheme: a kind of tonifying the kidney to regenerate bone marrow symplectic bone agent of accelerating union of bone fracture, is made up of the crude drug of following parts by weight: Pyritum 45g, Rhizoma Drynariae 12g, Radix Dipsaci 10g, Semen Cuscutae 10g, Fructus Schisandrae Chinensis 10g, Radix Cyathulae 12g, Radix Salviae Miltiorrhizae 12g, Caulis Spatholobi 12g, eupolyphaga 12g, Olibanum 10g, Myrrha 10g, Flos Carthami 10g, Radix Angelicae Sinensis 10g, Radix Astragali 25g, Radix Paeoniae Alba 12g, Rhizoma Alismatis 10g, Herba Lycopi 10g, Radix Angelicae Pubescentis 10g, Rhizoma Chuanxiong 10g, Radix Glycyrrhizae 8g, is decocted in water for oral dose.
Another kind of prioritization scheme: a kind of tonifying the kidney to regenerate bone marrow symplectic bone agent of accelerating union of bone fracture, is made up of the crude drug of following parts by weight: Pyritum 55g, Rhizoma Drynariae 18g, Radix Dipsaci 15g, Semen Cuscutae 15g, Fructus Schisandrae Chinensis 15g, Radix Cyathulae 18g, Radix Salviae Miltiorrhizae 18g, Caulis Spatholobi 18g, eupolyphaga 18g, Olibanum 15g, Myrrha 15g, Flos Carthami 15g, Radix Angelicae Sinensis 15g, Radix Astragali 35g, Radix Paeoniae Alba 18g, Rhizoma Alismatis 15g, Herba Lycopi 15g, Radix Angelicae Pubescentis 15g, Rhizoma Chuanxiong 15g, Radix Glycyrrhizae 10g, is decocted in water for oral dose.
In above-mentioned prescription: Pyritum has effect of eliminating stasis to stop pain, reunion of fractured tendons and bones; Rhizoma Drynariae has effect of the kidney invigorating bone strengthening, promoting blood circulation and stopping pain; Radix Dipsaci has and cures mainly aching pain in waist and back; Podomere flaccidity syndrome and arthralgia syndrome; Fall flutter wound, damage muscle folding bone, effect that carbuncle skin ulcer is swollen; Semen Cuscutae has the merit of continuous wound absolutely, tonifying for the deficiency, the strong people of benefit.The power of Fructus Schisandrae Chinensis energy strengthening by means of tonics, medical value is high, has the effect of building body.Radix Cyathulae is used for injury from falling down, rheumatic arthralgia.Radix Salviae Miltiorrhizae has blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, and clear away heart-fire relieving restlessness, effect of removing heat from blood eliminating carbuncle.Caulis Spatholobi has relaxing muscles and tendons to promote blood circulation, effect of nourishing blood for regulating menstruation; Eupolyphaga has promoting blood circulation to remove blood stasis, effect of inducing menstruation to relieve menalgia.Olibanum have invigorate blood circulation, circulation of qi promoting, pain relieving effect; Myrrha has effect of blood stasis dispelling, detumescence, analgesic therapy; Flos Carthami has promoting blood circulation to restore menstrual flow, effect of eliminating stasis to stop pain; Radix Angelicae Sinensis has to enrich blood invigorates blood circulation, menstruction regulating and pain relieving, moisturizes effect of laxation; The Radix Astragali has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress effect;
The Radix Paeoniae Alba has the effects such as blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain, astringing YIN to stop sweating; Rhizoma Alismatis has tonifying deficiency five kinds of over strain, except effect of the five internal organs feeling of fullness; Herba Lycopi has effect of wind dispelling analgesia; Radix Angelicae Pubescentis has expelling wind and removing dampness, effect of arthralgia aggravated by cold pain relieving; Rhizoma Chuanxiong has blood-activating and qi-promoting, effect of wind-expelling pain-stopping, and Radix Glycyrrhizae has effect of heat-clearing and toxic substances removing.
The present invention adopts such scheme, and Pyritum is synthetism panacea, is monarch.Rhizoma Drynariae, Radix Dipsaci, Semen Cuscutae, Fructus Schisandrae Chinensis, Radix Cyathulae tonifying the kidney to regenerate bone marrow are minister, Radix Salviae Miltiorrhizae, Caulis Spatholobi, eupolyphaga, Olibanum, Myrrha, Flos Carthami, Radix Angelicae Sinensis, the Radix Astragali, the Radix Paeoniae Alba, Rhizoma Alismatis, Herba Lycopi, Radix Angelicae Pubescentis blood circulation promoting and blood stasis dispelling, and promoting flow of QI and blood pain relieving is assistant.Rhizoma Chuanxiong, Radix Glycyrrhizae are gas medicine in blood, and coordinating the actions of various ingredients in a prescription is for making, and the present invention take the kidney invigorating as this, help with promoting flow of QI and blood dredging collateral as mark.Treating both the principal and secondary aspects of a disease, medicine disease is in step with, then control and test.We cure mainly fracture surgery callus and generate slow, and the patient that healing time extends, has special efficacy.
Through clinical trial, the present invention has good curative effect to accelerating union of bone fracture, and toxic and side effects is little, and prevention prolonged administration of drugs is to the injury of taste internal organs, and medication is safer.Each course for the treatment of is 30 days, and once, external application can be cured after 1 ~ 3 course for the treatment of, and cure rate reaches more than 88.5% in the external application course for the treatment of.
The present invention is through rational compatibility, the synergism of each Chinese medicine, treating both the principal and secondary aspects of a disease, both by adjusting and reinforcing liver and kidney, promoted growth of spur, improved osteoblastic activity and quantity, promote calcified bone matrix, acceleration callus is transformed, and can also alleviate local pain, have more advantage than simple compound and biological preparation.
Detailed description of the invention
Embodiment 1: a kind of tonifying the kidney to regenerate bone marrow symplectic bone agent of accelerating union of bone fracture, is made up of the crude drug of following parts by weight: Pyritum 45g, Rhizoma Drynariae 12g, Radix Dipsaci 10g, Semen Cuscutae 10g, Fructus Schisandrae Chinensis 10g, Radix Cyathulae 12g, Radix Salviae Miltiorrhizae 12g, Caulis Spatholobi 12g, eupolyphaga 12g, Olibanum 10g, Myrrha 10g, Flos Carthami 10g, Radix Angelicae Sinensis 10g, Radix Astragali 25g, Radix Paeoniae Alba 12g, Rhizoma Alismatis 10g, Herba Lycopi 10g, Radix Angelicae Pubescentis 10g, Rhizoma Chuanxiong 10g, Radix Glycyrrhizae 8g, is decocted in water for oral dose.
Embodiment 2: a kind of tonifying the kidney to regenerate bone marrow symplectic bone agent of accelerating union of bone fracture, is made up of the crude drug of following parts by weight: Pyritum 50g, Rhizoma Drynariae 15g, Radix Dipsaci 12g, Semen Cuscutae 12g, Fructus Schisandrae Chinensis 12g, Radix Cyathulae 15g, Radix Salviae Miltiorrhizae 15g, Caulis Spatholobi 15g, eupolyphaga 15g, Olibanum 12g, Myrrha 12g, Flos Carthami 12g, Radix Angelicae Sinensis 12g, Radix Astragali 30g, Radix Paeoniae Alba 15g, Rhizoma Alismatis 12g, Herba Lycopi 12g, Radix Angelicae Pubescentis 12g, Rhizoma Chuanxiong 12g, Radix Glycyrrhizae 9g, is decocted in water for oral dose.
Embodiment 3: a kind of tonifying the kidney to regenerate bone marrow symplectic bone agent of accelerating union of bone fracture, is made up of the crude drug of following parts by weight: Pyritum 55g, Rhizoma Drynariae 18g, Radix Dipsaci 15g, Semen Cuscutae 15g, Fructus Schisandrae Chinensis 15g, Radix Cyathulae 18g, Radix Salviae Miltiorrhizae 18g, Caulis Spatholobi 18g, eupolyphaga 18g, Olibanum 15g, Myrrha 15g, Flos Carthami 15g, Radix Angelicae Sinensis 15g, Radix Astragali 35g, Radix Paeoniae Alba 18g, Rhizoma Alismatis 15g, Herba Lycopi 15g, Radix Angelicae Pubescentis 15g, Rhizoma Chuanxiong 15g, Radix Glycyrrhizae 10g, is decocted in water for oral dose.
For investigating clinical efficacy and the safety of above-described embodiment medicine further, the treatment curative effect of case to medicine of the present invention that we have selected 800 example fracture carries out clinical trial.
The patient of 800 example fracture is divided into four groups at random, often organizes 200 examples.In matched group, male 100 example, women 100 example; Less than 20 years old 15 examples, 21 ~ 35 years old 65 example, 36 ~ 50 years old 70 example, more than 51 years old 50 example; In treatment group 1, male 100 example, women 100 example; Less than 20 years old 14 examples, 21 ~ 35 years old 63 example, 36 ~ 50 years old 71 example, more than 51 years old 52 example; In treatment group 2, male 105 example, women 95 example; Less than 20 years old 15 examples, 21 ~ 35 years old 64 example, 36 ~ 50 years old 69 example, more than 51 years old 52 example; In treatment group 3, male 100 example, women 100 example; Less than 20 years old 14 examples, 21 ~ 35 years old 62 example, 36 ~ 50 years old 70 example, more than 51 years old 54 example.
Four groups of cases through statistical analysis, have comparability in sex, age, the course of disease etc.
Matched group adopts the medicine of common oral accelerating union of bone fracture to treat; Treatment group 1 takes the medicine obtained by the present embodiment 1 orally; Treatment group 2 takes the medicine obtained by the present embodiment 2 orally; Treatment group 3 takes the medicine obtained by the present embodiment 3 orally, and three groups for the treatment of groups are all morning every day, late each potion, and within 7 days, be a course for the treatment of, interval 2-3 days, takes 2-3 the course for the treatment of continuously.
Criterion of therapeutical effect: cure: union of fracture is complete, fracture line disappears; Effective: fracture end has obvious callus formation, and fracture line is fuzzy; Effective: fracture end has obvious callus formation, and fracture gap narrows, activity without exception; Invalid: fracture end is without obvious callus formation, and fracture line is high-visible, with unchanged before treatment.Curative effect comparision result after four groups of case treatments is as table one.
Table one
| Group | Number of cases | Cure n (%) | Effective n (%) | Effective n (%) | Invalid n (%) |
| Matched group | 200 | 154(77) | 162(81) | 175(87.5) | 25(12.5) |
| Treatment group 1 | 200 | 177(88.5) | 187(93.5) | 191(95.5) | 9(4.5) |
| Treatment group 2 | 200 | 178(89) | 188(94) | 192(96) | 8(4) |
| Treatment group 3 | 200 | 177(88.5) | 187(93.5) | 191(95.5) | 9(4.5) |
By above-mentioned contrast, can find out and use treatment by Chinese herbs of the present invention fracture, therapeutic effect is remarkable, and compared with conventional oral medicine, cure rate is high.
The present invention has good curative effect to accelerating union of bone fracture, and have no side effect, do not develop immunity to drugs, 7 days is a course for the treatment of, after taking a course for the treatment of, interval 2-3 days, continue to take the next course for the treatment of, take 2-3 the course for the treatment of continuously, external application can be cured after 1 ~ 3 course for the treatment of again, cure rate reaches more than 88.5%, and effective percentage reaches 95.5%.
Some patients healing case is as follows:
Field, man, 28 years old, fracture of tibia, after taking 2 courses for the treatment of of medicine obtained by the present embodiment 1, patients symptomatic disappeared, recovery from illness.
Shut out certain, female, 39 years old, fracture of the femoral head, and after taking 3 courses for the treatment of of medicine obtained by the present embodiment 2, patients symptomatic disappears, recovery from illness.
Poplar, man, 41 years old, fracture of nasal bone, after taking 1 course for the treatment of of medicine obtained by the present embodiment 3, patients symptomatic disappeared, recovery from illness.
Luo, man, 18 years old, comminuted fracture of patella, after taking 3 courses for the treatment of of medicine obtained by the present embodiment 2, patients symptomatic disappeared, recovery from illness.
Claims (4)
1. a tonifying the kidney to regenerate bone marrow symplectic bone agent for accelerating union of bone fracture, is characterized in that: be made up of the crude drug of following parts by weight: Pyritum 45-55g, Rhizoma Drynariae 12-18g, Radix Dipsaci 10-15g, Semen Cuscutae 10-15g, Fructus Schisandrae Chinensis 10-15g, Radix Cyathulae 12-18g, Radix Salviae Miltiorrhizae 12-18g, Caulis Spatholobi 12-18g, eupolyphaga 12-18g, Olibanum 10-15g, Myrrha 10-15g, Flos Carthami 10-15g, Radix Angelicae Sinensis 10-15g, Radix Astragali 25-35g, Radix Paeoniae Alba 12-18g, Rhizoma Alismatis 10-15g, Herba Lycopi 10-15g, Radix Angelicae Pubescentis 10-15g, Rhizoma Chuanxiong 10-15g, Radix Glycyrrhizae 8-10g, is decocted in water for oral dose.
2. the tonifying the kidney to regenerate bone marrow symplectic bone agent of a kind of accelerating union of bone fracture according to claim 1, is characterized in that: be made up of the crude drug of following parts by weight: Pyritum 50g, Rhizoma Drynariae 15g, Radix Dipsaci 12g, Semen Cuscutae 12g, Fructus Schisandrae Chinensis 12g, Radix Cyathulae 15g, Radix Salviae Miltiorrhizae 15g, Caulis Spatholobi 15g, eupolyphaga 15g, Olibanum 12g, Myrrha 12g, Flos Carthami 12g, Radix Angelicae Sinensis 12g, Radix Astragali 30g, Radix Paeoniae Alba 15g, Rhizoma Alismatis 12g, Herba Lycopi 12g, Radix Angelicae Pubescentis 12g, Rhizoma Chuanxiong 12g, Radix Glycyrrhizae 9g, is decocted in water for oral dose.
3. the tonifying the kidney to regenerate bone marrow symplectic bone agent of a kind of accelerating union of bone fracture according to claim 1, is characterized in that: be made up of the crude drug of following parts by weight:
Pyritum 45g, Rhizoma Drynariae 12g, Radix Dipsaci 10g, Semen Cuscutae 10g, Fructus Schisandrae Chinensis 10g, Radix Cyathulae 12g, Radix Salviae Miltiorrhizae 12g, Caulis Spatholobi 12g, eupolyphaga 12g, Olibanum 10g, Myrrha 10g, Flos Carthami 10g, Radix Angelicae Sinensis 10g, Radix Astragali 25g, Radix Paeoniae Alba 12g, Rhizoma Alismatis 10g, Herba Lycopi 10g, Radix Angelicae Pubescentis 10g, Rhizoma Chuanxiong 10g, Radix Glycyrrhizae 8g, is decocted in water for oral dose.
4. the tonifying the kidney to regenerate bone marrow symplectic bone agent of a kind of accelerating union of bone fracture according to claim 1, is characterized in that: be made up of the crude drug of following parts by weight: Pyritum 55g, Rhizoma Drynariae 18g, Radix Dipsaci 15g, Semen Cuscutae 15g, Fructus Schisandrae Chinensis 15g, Radix Cyathulae 18g, Radix Salviae Miltiorrhizae 18g, Caulis Spatholobi 18g, eupolyphaga 18g, Olibanum 15g, Myrrha 15g, Flos Carthami 15g, Radix Angelicae Sinensis 15g, Radix Astragali 35g, Radix Paeoniae Alba 18g, Rhizoma Alismatis 15g, Herba Lycopi 15g, Radix Angelicae Pubescentis 15g, Rhizoma Chuanxiong 15g, Radix Glycyrrhizae 10g, is decocted in water for oral dose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510167338.0A CN104800443B (en) | 2015-04-02 | 2015-04-02 | A kind of raw marrow symplectic bone agent of kidney tonifying |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510167338.0A CN104800443B (en) | 2015-04-02 | 2015-04-02 | A kind of raw marrow symplectic bone agent of kidney tonifying |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104800443A true CN104800443A (en) | 2015-07-29 |
| CN104800443B CN104800443B (en) | 2019-01-22 |
Family
ID=53685927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510167338.0A Expired - Fee Related CN104800443B (en) | 2015-04-02 | 2015-04-02 | A kind of raw marrow symplectic bone agent of kidney tonifying |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104800443B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412462A (en) * | 2015-12-18 | 2016-03-23 | 东阳市人民医院 | Bone setting granules and production method thereof |
| CN105998439A (en) * | 2016-07-15 | 2016-10-12 | 王士杰 | Symplectic bone medicine and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101623415A (en) * | 2009-08-07 | 2010-01-13 | 葛超顺 | Traditional Chinese medicine preparation for treating fractures and bone injuries |
| CN102579605A (en) * | 2012-03-12 | 2012-07-18 | 高永学 | Oral Chinese medicinal composition for treating bone fracture diseases |
| CN103877556A (en) * | 2014-04-17 | 2014-06-25 | 崔贵成 | Traditional Chinese medicine plaster for bone injury and fracture |
-
2015
- 2015-04-02 CN CN201510167338.0A patent/CN104800443B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101623415A (en) * | 2009-08-07 | 2010-01-13 | 葛超顺 | Traditional Chinese medicine preparation for treating fractures and bone injuries |
| CN102579605A (en) * | 2012-03-12 | 2012-07-18 | 高永学 | Oral Chinese medicinal composition for treating bone fracture diseases |
| CN103877556A (en) * | 2014-04-17 | 2014-06-25 | 崔贵成 | Traditional Chinese medicine plaster for bone injury and fracture |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412462A (en) * | 2015-12-18 | 2016-03-23 | 东阳市人民医院 | Bone setting granules and production method thereof |
| CN105998439A (en) * | 2016-07-15 | 2016-10-12 | 王士杰 | Symplectic bone medicine and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104800443B (en) | 2019-01-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102309644B (en) | Traditional Chinese medical composition for treating bone fracture | |
| CN103156972B (en) | Traditional Chinese medicine combination for treating fracture, hairline fracture and traumatic injury | |
| CN102512630B (en) | Traditional Chinese medicine composition for treating gallbladder calculus | |
| CN103006951A (en) | Chinese medicinal composition for treating cervical spondylosis and lumbar spondylosis | |
| CN103536858B (en) | Medicine for treating rheumatoid arthritis | |
| CN105560662A (en) | External-use traditional Chinese medicine composition for treating knee osteoarthritis | |
| CN101450197B (en) | Traditional Chinese medicine for treating rheumatism, rheumatoid disease | |
| CN104758659A (en) | Traditional Chinese medicine paste for treating muscle and bone diseases | |
| CN102247497A (en) | Chinese patent medicine for treating rheumatoid arthritis | |
| CN106266896A (en) | A kind of invigorating primordial QI, kidney invigorating and YANG supporting, bone and muscle strengthening, the pill of curing rheumatism | |
| CN103316296B (en) | Traditional Chinese medicine composition for treating hyperostosis | |
| CN104800443B (en) | A kind of raw marrow symplectic bone agent of kidney tonifying | |
| CN103446360B (en) | Traditional Chinese medicine capsule preparation for treating lumbar disc herniation and preparation method of traditional Chinese medicine capsule preparation | |
| CN103285203B (en) | Traditional Chinese medicine composition for preventing and treating bone fracture and preparation method thereof | |
| CN104922363A (en) | Traditional Chinese medicine composite for treating osteoproliferation | |
| CN101703619A (en) | Chinese medicament for treating hyperosteogeny and osteoarthritis | |
| CN101690779B (en) | Traditional Chinese medicine for oral taking for treating scapulohumeral periarthritis | |
| CN102512543B (en) | Chinese medicinal composition for treating rheumatoid arthritis | |
| CN105169279A (en) | Traditional Chinese medicine composition for treating knee joint bone hyperplasia | |
| CN105287731A (en) | Externally-applied traditional Chinese medicine preparation for treating hyperostosis and preparation method thereof | |
| CN104524080A (en) | Traditional Chinese medicine preparation for treating injuries from falls, fractures, contusions and strains and preparation method | |
| CN104547489A (en) | Use of traditional Chinese medicine composition in preparation of medicine for treating comminuted fracture | |
| CN112755134B (en) | Plaster for treating hyperosteogeny and preparation method thereof | |
| CN105816603A (en) | Traditional Chinese medicine composition for treating postpartum hemorrhage | |
| CN104758539A (en) | Traditional Chinese medicine composition for treating debilitation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190122 |