CN108126021B - Traditional Chinese medicine mouth wash for treating kidney deficiency type loose and floating tooth and falling off and preparation method thereof - Google Patents
Traditional Chinese medicine mouth wash for treating kidney deficiency type loose and floating tooth and falling off and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of mouthwash, and particularly relates to traditional Chinese medicine mouthwash for treating kidney deficiency type loose and floating tooth and falling off and a preparation method thereof. The traditional Chinese medicine mouth wash for treating the deficiency of the kidney type loose and shed teeth comprises the following components in parts by weight: 10-100 parts of radix aconiti praeparata, 10-100 parts of halitum, 10-80 parts of fructus psoraleae, 10-100 parts of gypsum and 10-40 parts of mint leaves. The composition is extracted by related technologies, and then is mixed with auxiliary materials to prepare mouthwash for clinical use. Clinical application and pharmacological experiments prove that the medicament has obvious treatment effect and definite curative effect on the loose and loose teeth and the falling teeth, and particularly has obvious curative effect on the loose and fallen teeth symptom caused by kidney deficiency.
Description
Technical Field
The invention belongs to the field of mouthwash, and particularly relates to traditional Chinese medicine mouthwash for treating kidney deficiency type loose and floating tooth and falling off and a preparation method thereof.
Background
Tooth loosening is a disease very common in the elderly, and has been gradually advancing toward the direction of younger people in recent years. The tooth loosening not only affects the normal chewing function of the human body, but also can cause deep dental diseases, gastrointestinal diseases and even can induce various visceral diseases. The loose teeth seriously affect the physical and mental health and the life quality of the human body.
The traditional Chinese medicine considers that the kidney governs bones, the teeth are the rest of bones, the kidney qi is weak, the essence is deficient, the teeth are out of nourishment, and the teeth are shaken due to the insecurity of the teeth. For example, it is mentioned in nan Song & Yang ShiYing (Renzhai Zhi Fang): the nourishing of the marrow and the kidney-excess are the main factors of the tooth, bone and marrow. Therefore, kidney failure breaks the teeth open and essence is preponderant, causing the teeth to be hard. For this reason, kidney failure can lead to tooth deficiency, while essence can lead to tooth stiffness, and kidney qi deficiency is mainly indicated for kidney qi deficiency, because teeth are brittle and not firm, or easy to shake or loose. The Ming and Yu Biu & Ling & lt & ltmedical science formal & gt proposes: "either mean pain and tooth shaking, or mean pain and insect erosion, and also mean that there is inconvenience in eating and drinking due to the gap between teeth. For the patients with the large gingival atrophy and fluctuation, it is essential to nourish yin and tonify kidney for kidney-essence deficiency. "
The invention patent with application number 201410111751.0, a traditional Chinese medicine mouthwash and a preparation method thereof (application date: 2014.03.24), introduces a traditional Chinese medicine mouthwash. The product is prepared from Aloe, Saviae Miltiorrhizae radix, herba Leonuri, radix Angelicae Dahuricae, lemon oil, menthol, Perilla oil, oleum Caryophylli, ethanol, and distilled water. Has the effects of temporarily eliminating peculiar smell in the mouth, disinfecting and sterilizing, but can not play a role in treating the symptom of tooth loosening and falling caused by kidney deficiency.
The invention patent with application number 201310617519.X 'a mouthwash for preventing dental ulcer' (application date: 2013.11.29) introduces a traditional Chinese medicine mouthwash. The product is prepared from flos Chrysanthemi Indici, flos Lonicerae, Scutellariae radix, cortex Phellodendri, folium Camelliae sinensis, herba Menthae, folium Artemisiae Argyi, herba Dendrobii, radix Gentianae, bupleuri radix, fructus Aurantii, rhizoma corydalis, rhizoma Cyperi, radix Curcumae, Mel, fructus crataegi, Raphani radix, fructus Momordicae Charantiae, rhizoma Nelumbinis, rhizoma Zingiberis recens, and herba Hedyotidis Diffusae. The product can effectively prevent oral ulcer, but has no effect on symptoms of teeth loosening and falling caused by kidney deficiency.
The invention patent with application No. 201410313736.4, entitled "mouthwash for caring oral cavity and preparation method thereof" (application date: 2014.07.03), discloses a mouthwash. The product is prepared from a traditional Chinese medicine concentrated solution I, a traditional Chinese medicine concentrated solution II, flower tea juice, tea polyphenol, metronidazole, erythromycin and water. The product can clear heat, relieve pain, resist bacteria and diminish inflammation, effectively prevent oral diseases, and prevent the occurrence of symptoms such as decayed teeth, dental neuralgia, dental ulcer and the like, but the product uses antibiotic raw materials, is not beneficial to body health after long-term use, and has no effect on kidney deficiency type odontoseisis.
The mainstream mouth wash in the market, namely Lischdelin, is prepared from eucalyptol, menthol, methyl salicylate, thymol, water, ethanol, sorbitol, poloxamer 407, benzoic acid, zinc chloride, sodium benzoate, sucralose, essence, saccharin sodium, blue pigment and the like. The components are mostly chemical agents, so that the long-term use is not suitable. Moreover, the product is mainly used for preventing and reducing tooth stain and gingivitis, and cannot play a role in treating the symptoms of tooth loosening and falling caused by kidney deficiency.
At present, the varieties of the mouth wash are mainly focused on sterilization and breath freshening, but the problem of loose teeth caused by kidney deficiency is not caused by the saliva.
Disclosure of Invention
To solve the problems set forth in the background art described above,
the invention aims to provide the traditional Chinese medicine mouthwash for treating the deficiency of the kidney type loose and fallen teeth, which fills the blank of the traditional Chinese medicine mouthwash for treating or preventing the deficiency of the kidney type loose and fallen teeth in the prior art, improves the safety of the mouthwash, has no toxic or side effect on human bodies, has obvious treatment effect on the loose and fallen teeth and definite treatment effect, and particularly has obvious treatment effect on the loose and fallen teeth symptom caused by the deficiency of the kidney.
The invention also aims to provide a preparation method of the traditional Chinese medicine mouthwash for treating the deficiency of the kidney type loose and loose teeth and the exfoliation, which combines the traditional Chinese medicine formula with scientific and technical means, extracts the effective components to the maximum extent, improves the efficacy of the traditional Chinese medicine and is convenient to popularize and use.
In order to achieve the purpose, the invention provides the following technical scheme:
the first scheme is as follows:
a Chinese medicinal collutory for treating deficiency of the kidney type loose and loose teeth and exfoliation comprises radix Aconiti lateralis Preparata, Halitum, fructus Psoraleae, Gypsum Fibrosum and folium Menthae.
A traditional Chinese medicine mouth wash for treating kidney deficiency type loose and shed teeth comprises the following components in parts by weight: 10-100 parts of radix aconiti praeparata, 10-100 parts of halitum, 10-80 parts of fructus psoraleae, 10-100 parts of gypsum and 10-40 parts of mint leaves.
Preferably, the traditional Chinese medicine mouth wash for treating kidney deficiency type loose and loose teeth and exfoliation comprises the following components in parts by weight: 30-80 parts of radix aconiti praeparata, 30-80 parts of halitum, 30-60 parts of fructus psoraleae, 30-80 parts of gypsum and 15-35 parts of mint leaves.
Preferably, the teeth loose and fall off is kidney deficiency type teeth loose and fall off.
Scheme II:
a preparation method of traditional Chinese medicine mouth wash for treating kidney deficiency type loose and falling teeth comprises the following steps:
(1) pulverizing radix Aconiti lateralis Preparata, adding purified water, homogenizing, sterilizing, inoculating strain, fermenting, lyophilizing to obtain fermented product, pulverizing, and sieving to obtain fermented powder;
(2) pulverizing folium Menthae, adding purified water, and adding CO2Performing supercritical extraction for 1-3 times, and extracting volatile oil for later use;
(3) collecting fructus Psoraleae and Gypsum Fibrosum, adding purified water, concentrating, extracting to obtain concentrated solution, drying to obtain dry extract, pulverizing, and sieving to obtain dry extract powder;
(4) mixing the dry extract powder, volatile oil, fermented powder, Halitum and adjuvants, and making into collutory.
The mass ratio of the rhizoma typhonii powder to the purified water is 1: 5-20, the homogenizing pressure is 0.15-0.35 Mpa, the homogenizing time is 5-15 min, the sterilization temperature is 100-120 ℃, the sterilization time is 30-55 min, the inoculated strain is trametes cinnabarinus, the fermentation temperature is 20-40 ℃, the fermentation humidity is 45-75%, the fermentation time is 20-45 d, and the sieving mesh number is 60-200 meshes; mint leaf CO2The flow rate of supercritical extraction is 20-60L/h, the temperature is 32-37 ℃, the pressure is 20-70 MPa, and the time is 30-80 min; the vacuum degree of gypsum and fructus psoraleae concentration is-0.05 Mpa to-0.10 Mpa, the concentration temperature is 50-100 ℃, and the specific gravity of the liquid medicine is concentrated to 1.00-1.25.
Preferably, the mass ratio of the rhizoma typhonii powder to the purified water is 1:13, the homogenizing pressure is 0.25Mpa, the homogenizing time is 10min, the sterilization temperature is 110 ℃, the sterilization time is 43min, the inoculated strain is trametes cinnabarinus, the fermentation temperature is 30 ℃, the fermentation humidity is 60%, the fermentation time is 33d, and the mesh number is 130 meshes; mint leaf CO2The flow rate of supercritical extraction is 40L/h, the temperature is 35 ℃, the pressure is 45MPa, and the time is 55 min; concentrating Gypsum Fibrosum and fructus Psoraleae at-0.08 Mpa and 75 deg.C to obtain medicinal liquid with specific gravity of 1.13.
Preferably, the auxiliary materials comprise microcrystalline cellulose, alcohol and purified water.
Preferably, the preparation method of the traditional Chinese medicine mouth wash for treating kidney deficiency type loose and floating tooth and exfoliation is characterized by comprising the following steps: the preparation type is mouthwash or granules.
Compared with the prior art, the invention has the beneficial effects that:
1. the traditional Chinese medicine mouth wash for treating the deficiency of the kidney type loose and loose teeth and exfoliation supplements the blank of the traditional Chinese medicine mouth wash for treating or preventing the deficiency of the kidney type loose and exfoliation teeth in the prior art, improves the safety of the mouth wash, has no toxic or side effect on human bodies, has obvious treatment effect on the loose and exfoliation teeth and definite treatment effect, and particularly has obvious treatment effect on the loose and exfoliation teeth symptoms caused by the deficiency of the kidney.
2. The active effective components of the aconite tuber, such as alkaloid, are retained by a fermentation method, toxic substances are removed, the effective utilization rate of the aconite tuber is improved, the self-repairing capability of gingival cells is stimulated, and secondary damage to gingiva, an organism and the like caused by treatment is avoided, so that the gingiva is repaired, and the teeth are fixed and are prevented from falling off.
3. By adopting pure natural plant raw materials, all effective components of the product are controlled within a range which can be tolerated by human bodies, and the product has high safety evaluation.
4. Combines the traditional Chinese medicine formula with scientific and technical means, extracts effective components to the maximum extent, improves the efficacy of the traditional Chinese medicine, and is convenient for popularization and use.
5. The formula is prepared by taking the theory of traditional Chinese medicine as guidance and taking careful prescription. The recipe of Zhong Pao Fu Zi is pungent, sweet and hot, and good at tonifying fire and supporting yang, and restoring yang and rescuing collapse, it is the monarch herb. Bu Gu Zhi is pungent, bitter and warm in property, can warm kidney and strengthen yang, receive qi and check diarrhea, and strengthen the effect of Bu Fu Zi in tonifying kidney and strengthening yang, which is the ministerial drug. Radix Aconiti lateralis Preparata and fructus Psoraleae are warm-heat products, and Gypsum Fibrosum, with sweet, pungent and cold natures, has effects of clearing heat and fire, relieving restlessness and quenching thirst; the mint is pungent and cool, can disperse wind-heat, has the function of clearing head and eyes, and can relieve the warm nature of the processed aconite and the psoralea, and the two medicines are adjuvant medicines. Da Qing Yan is salty and cold, enters heart and kidney meridians to cool blood and improve vision, so it is used as a guide to meridian. The medicines are combined to play the effects of warming the kidney, absorbing qi, strengthening the teeth and preventing alopecia.
6. Clinical application and pharmacological experiments prove that the medicament has obvious treatment effect and definite curative effect on the loose and fallen teeth, and particularly has obvious curative effect on the symptom of the loose and fallen teeth caused by kidney deficiency.
7. Compared with the prior art, the invention has the following beneficial effects:
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
A Chinese medicinal collutory for treating deficiency of the kidney type loose and loose teeth and exfoliation comprises radix Aconiti lateralis Preparata, Halitum, fructus Psoraleae, Gypsum Fibrosum and folium Menthae.
Wherein the processed radix Aconiti lateralis is dried radix Aconiti lateralis Preparata of Aconitum carmichaeli Debx of Ranunculaceae; pungent, sweet and warm in flavor; entering heart, spleen and kidney meridians; reviving yang, rescuing from collapse, supplementing fire and supporting yang;
fructus Psoraleae, which is dried mature fruit of Psoraleacor ylifolila L. of Leguminosae; pungent and bitter taste, warm nature; entering kidney and spleen meridians; warming kidney and tonifying yang, receiving qi and checking diarrhea;
gypsum, which is sulfate mineral anhydrite gypsum family gypsum; sweet and pungent in flavor and cold in nature; entering lung and stomach meridians; clearing heat and purging fire, relieving restlessness and quenching thirst;
mint leaf, which is dried leaf of Mentha haphallocalyxBriq.of Labiatae; pungent taste and cool nature; entering lung and liver meridians; disperse wind-heat, clear head and eyes, promote eruption;
halite, which is a halide rock salt lake salt crystal; salty taste and cold nature; entering heart and kidney meridians; cool blood, improve vision.
Further, the traditional Chinese medicine mouth wash for treating the kidney deficiency type loose and loose teeth and exfoliation comprises the following components in parts by weight: 10-100 parts of radix aconiti praeparata, 10-100 parts of halitum, 10-80 parts of fructus psoraleae, 10-100 parts of gypsum and 10-40 parts of mint leaves.
Further, the traditional Chinese medicine mouth wash for treating the kidney deficiency type loose and loose teeth and exfoliation comprises the following components in parts by weight: 30-80 parts of radix aconiti praeparata, 30-80 parts of halitum, 30-60 parts of fructus psoraleae, 30-80 parts of gypsum and 15-35 parts of mint leaves.
A preparation method of traditional Chinese medicine mouth wash for treating kidney deficiency type loose and falling teeth comprises the following steps:
(1) pulverizing radix Aconiti lateralis Preparata, adding purified water, homogenizing, sterilizing, inoculating strain, fermenting, lyophilizing to obtain fermented product, pulverizing, and sieving to obtain fermented powder;
(2) pulverizing folium Menthae, adding purified water, and adding CO2Performing supercritical extraction for 1-3 times, and extracting volatile oil for later use;
(3) collecting fructus Psoraleae and Gypsum Fibrosum, adding purified water, concentrating, extracting to obtain concentrated solution, drying to obtain dry extract, pulverizing, and sieving with 100 mesh sieve to obtain dry extract powder;
(4) mixing the dry extract powder, volatile oil, fermented powder, Halitum and adjuvants, and making into collutory.
Further, the mass ratio of the rhizoma typhonii powder to the purified water is 1: 5-20, the homogenizing pressure is 0.15-0.35 Mpa, the homogenizing time is 5-15 min, the sterilization temperature is 100-120 ℃, the sterilization time is 30-55 min, the inoculated strain is trametes cinnabarinus, the fermentation temperature is 20-40 ℃, the fermentation humidity is 45-75%, the fermentation time is 20-45 d, and the sieving mesh number is 60-200 meshes; mint leaf CO2The flow rate of supercritical extraction is 20-60L/h, the temperature is 32-37 ℃, the pressure is 20-70 MPa, and the time is 30-80 min; the vacuum degree of gypsum and fructus psoraleae concentration is-0.05 Mpa to-0.10 Mpa, the concentration temperature is 50-100 ℃, and the specific gravity of the liquid medicine is concentrated to 1.00-1.25.
Furthermore, the mass ratio of the rhizoma typhonii powder to the purified water is 1:13, the homogenizing pressure is 0.25Mpa, the homogenizing time is 10min, the sterilization temperature is 110 ℃, the sterilization time is 43min, the inoculated strain is trametes cinnabarinus, the fermentation temperature is 30 ℃, the fermentation humidity is 60%, the fermentation time is 33d, and the mesh number is 130 meshes; mint leaf CO2The flow rate of supercritical extraction is 40L/h, the temperature is 35 ℃, the pressure is 45MPa, and the time is 55 min; concentrating Gypsum Fibrosum and fructus Psoraleae at-0.08 Mpa and 75 deg.C to obtain medicinal liquid with specific gravity of 1.13.
Further, the auxiliary materials comprise microcrystalline cellulose, alcohol and purified water.
Further, the preparation type is mouthwash or granules.
Further, the teeth loose and fall off is kidney deficiency type teeth loose and fall off.
Example 1:
a traditional Chinese medicine mouth wash for treating kidney deficiency type loose and loose teeth and exfoliation comprises, by weight, 30 parts of processed monkshood, 30 parts of halite, 20 parts of fructus psoraleae, 30 parts of gypsum and 10 parts of mint leaves.
(1) Pulverizing the processed radix Aconiti lateralis Preparata in the above formula, sieving with 80 mesh sieve, adding 20 times of purified water, homogenizing under 0.25Mpa for 5min, sterilizing at 120 deg.C for 43 min. After sterilization, strain inoculation is carried out, the inoculated strain is trametes cinnabarina, the mixture is placed into an incubator for fermentation, the fermentation temperature is 20 ℃, the fermentation humidity is 75%, and the fermentation time is 33 d. Uniformly and fully distributing the homogenized solution with mycelia, freezing at-4 deg.C overnight, taking out, freeze-drying in a freeze-dryer, pulverizing, and sieving with 80 mesh sieve to obtain fermented powder;
(2) taking the mint leaves in parts by weight of the formula, crushing, adding 5 times of purified water and mint leaf CO2Performing supercritical extraction for 3 times, wherein the flow rate is set to be 60L/h, the temperature is 35 ℃, the pressure is 20MPa, and the extraction time is 80min each time to obtain volatile oil for later use;
(3) taking the fructus psoraleae and the gypsum according to the weight parts of the formula, adding 7 times of purified water, carrying out reflux extraction for 3 times, each time for 30min, filtering, carrying out vacuum concentration, concentrating the liquid medicine to a specific gravity of 1.25 at a concentration temperature of 50 ℃ and a vacuum degree of-0.08 Mpa to obtain a concentrated solution, drying the concentrated solution to obtain dry paste, crushing the dry paste, and sieving the dry paste with a 80-mesh sieve to obtain dry paste powder for later use;
(4) mixing the dry extract powder, volatile oil, fermented powder, Halitum and adjuvants, and making into collutory.
Further, the auxiliary materials comprise microcrystalline cellulose, alcohol and purified water.
Further, the preparation types are mouthwash and granules.
Further, the teeth loose and fall off is kidney deficiency type teeth loose and fall off.
Example 2:
a traditional Chinese medicine mouth wash for treating kidney deficiency type loose and loose teeth and exfoliation comprises, by weight, 50 parts of processed monkshood, 50 parts of halite, 30 parts of fructus psoraleae, 40 parts of gypsum and 20 parts of mint leaves.
(1) Pulverizing the processed radix Aconiti lateralis Preparata in the above formula, sieving with 100 mesh sieve, adding 5 times of purified water, homogenizing under 0.35Mpa for 10min, sterilizing at 100 deg.C for 55 min. After sterilization, strain inoculation is carried out, the inoculated strain is trametes cinnabarina, the mixture is placed into an incubator for fermentation, the fermentation temperature is 30 ℃, the fermentation humidity is 45%, and the fermentation time is 45 d. Uniformly and fully distributing the homogenized solution with mycelia, freezing at-4 deg.C overnight, taking out, freeze-drying in a freeze-dryer, pulverizing, and sieving with 100 mesh sieve to obtain fermented powder;
(2) taking the mint leaves in parts by weight of the formula, crushing, adding 5 times of purified water and mint leaf CO2Performing supercritical extraction for 3 times, wherein the flow rate is set to be 20L/h, the temperature is 37 ℃, the pressure is 70MPa, and the extraction time is 30min each time to obtain volatile oil for later use;
(3) taking the fructus psoraleae and the gypsum according to the weight parts of the formula, adding 8 times of purified water, carrying out reflux extraction for 3 times, each time for 30min, filtering, carrying out vacuum concentration, concentrating the liquid medicine to obtain concentrated solution, drying the concentrated solution to obtain dry paste, crushing the dry paste, and sieving the dry paste with a 100-mesh sieve to obtain dry paste powder for later use, wherein the vacuum degree of the concentration is-0.1 Mpa, and the concentration temperature is 75 ℃;
(4) mixing the dry extract powder, volatile oil, fermented powder, Halitum and adjuvants, and making into collutory.
Further, the auxiliary materials comprise microcrystalline cellulose, alcohol and purified water.
Further, the preparation types are mouthwash and granules.
Further, the teeth loose and fall off is kidney deficiency type teeth loose and fall off.
Example 3:
a traditional Chinese medicine mouthwash for treating kidney deficiency type loose and loose teeth and exfoliation comprises, by weight, 80 parts of processed monkshood, 80 parts of halite, 50 parts of fructus psoraleae, 80 parts of gypsum and 30 parts of mint leaves
(1) Pulverizing the processed radix Aconiti lateralis Preparata in the above formula, sieving with 100 mesh sieve, adding 13 times of purified water, homogenizing under 0.15Mpa for 15min, sterilizing at 110 deg.C for 30 min. After sterilization, strain inoculation is carried out, the inoculated strain is trametes cinnabarina, the mixture is placed into an incubator for fermentation, the fermentation temperature is 40 ℃, the fermentation humidity is 60%, and the fermentation time is 20 days. Uniformly and fully distributing the homogenized solution with mycelia, freezing at-4 deg.C overnight, taking out, freeze-drying in a freeze-dryer, pulverizing, and sieving with 200 mesh sieve to obtain fermented powder;
(2) taking the mint leaves in parts by weight of the formula, crushing, adding 7 times of purified water and mint leaf CO2Performing supercritical extraction for 3 times, wherein the flow rate is 40L/h, the temperature is 32 deg.C, the pressure is 70MPa, and the extraction time is 55min each time to obtain volatile oil for use;
(3) taking the fructus psoraleae and the gypsum according to the weight parts of the formula, adding 10 times of purified water, carrying out reflux extraction for 3 times, 40min each time, filtering, carrying out vacuum concentration, wherein the vacuum degree of concentration is-0.05 Mpa, the concentration temperature is 100 ℃, concentrating the liquid medicine to the specific gravity of 1.13 to obtain concentrated solution, drying to obtain dry paste, crushing, and sieving by a 130-mesh sieve to obtain dry paste powder for later use;
(4) mixing the dry extract powder, volatile oil, fermented powder, Halitum and adjuvants, and making into collutory.
Further, the auxiliary materials comprise microcrystalline cellulose, alcohol and purified water.
Further, the preparation type is mouthwash or granules.
Further, the teeth loose and fall off is kidney deficiency type teeth loose and fall off.
The reliability and safety of the traditional Chinese medicine mouth wash for treating the deficiency of the kidney type loose and falling teeth produced in the embodiment 1-embodiment 3 of the invention are detected to completely meet the requirements of the national relevant standards, and the clinical treatment examples are as follows:
although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (5)
1. A traditional Chinese medicine mouth wash for treating kidney deficiency type loose and falling teeth is characterized in that: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 10-100 parts of radix aconiti praeparata, 10-100 parts of halitum, 10-80 parts of fructus psoraleae, 10-100 parts of gypsum and 10-40 parts of mint leaves.
2. The traditional Chinese medicine mouth wash for treating kidney deficiency type teeth loosening and falling as claimed in claim 1, is characterized in that: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 30-80 parts of radix aconiti praeparata, 30-80 parts of halitum, 30-60 parts of fructus psoraleae, 30-80 parts of gypsum and 15-35 parts of mint leaves.
3. The preparation method of the traditional Chinese medicine mouthwash for treating the deficiency of the kidney type loose and loose teeth and falling off according to claim 2 is characterized in that: the method comprises the following steps:
(1) pulverizing radix Aconiti lateralis Preparata, adding purified water, homogenizing, sterilizing, inoculating strain, fermenting, lyophilizing to obtain fermented product, pulverizing, and sieving to obtain fermented powder;
(2) pulverizing folium Menthae, adding purified water, and adding CO2Performing supercritical extraction for 1-3 times, and extracting volatile oil for later use;
(3) collecting fructus Psoraleae and Gypsum Fibrosum, adding purified water, concentrating, extracting to obtain concentrated solution, drying to obtain dry extract, pulverizing, and sieving to obtain dry extract powder;
(4) mixing the dry extract powder, volatile oil, fermentation powder, halite and adjuvants, and making into collutory;
the mass ratio of the rhizoma typhonii powder to the purified water is 1: 5-20, the homogenizing pressure is 0.15-0.35 Mpa, the homogenizing time is 5-15 min, and the sterilization temperature is100-120 ℃, the sterilization time is 30-55 min, the inoculated strain is trametes cinnabarina, the fermentation temperature is 20-40 ℃, the fermentation humidity is 45-75%, the fermentation time is 20-45 d, and the sieve mesh number is 60-200 meshes; mint leaf CO2The flow rate of supercritical extraction is 20-60L/h, the temperature is 32-37 ℃, the pressure is 20-70 MPa, and the time is 30-80 min; the vacuum degree of gypsum and fructus psoraleae concentration is-0.05 Mpa to-0.10 Mpa, the concentration temperature is 50-100 ℃, and the specific gravity of the liquid medicine is concentrated to 1.00-1.25.
4. The preparation method of the traditional Chinese medicine mouth wash for treating kidney deficiency type teeth loosening and falling as claimed in claim 3, is characterized in that: the mass ratio of the processed aconite powder to the purified water is 1:13, the homogenizing pressure is 0.25Mpa, the homogenizing time is 10min, the sterilizing temperature is 110 ℃, the sterilizing time is 43min, the inoculated strain is trametes cinnabarinus, the fermenting temperature is 30 ℃, the fermenting humidity is 60%, the fermenting time is 33d, and the mesh number is 130 meshes; mint leaf CO2The flow rate of supercritical extraction is 40L/h, the temperature is 35 ℃, the pressure is 45MPa, and the time is 55 min; concentrating Gypsum Fibrosum and fructus Psoraleae at-0.08 Mpa and 75 deg.C to obtain medicinal liquid with specific gravity of 1.13.
5. The preparation method of the traditional Chinese medicine mouth wash for treating kidney deficiency type teeth loosening and falling as claimed in claim 3, is characterized in that: the adjuvants are microcrystalline cellulose, alcohol and purified water.
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