CN104383298B - A kind of Chinese medicine composition of promotion union - Google Patents
A kind of Chinese medicine composition of promotion union Download PDFInfo
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- CN104383298B CN104383298B CN201410627736.1A CN201410627736A CN104383298B CN 104383298 B CN104383298 B CN 104383298B CN 201410627736 A CN201410627736 A CN 201410627736A CN 104383298 B CN104383298 B CN 104383298B
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- 239000003814 drug Substances 0.000 title claims abstract description 40
- 239000000203 mixture Substances 0.000 title claims abstract description 24
- 235000001287 Guettarda speciosa Nutrition 0.000 claims abstract description 19
- 244000247747 Coptis groenlandica Species 0.000 claims abstract description 18
- 235000002991 Coptis groenlandica Nutrition 0.000 claims abstract description 18
- 210000001320 hippocampus Anatomy 0.000 claims abstract description 17
- 229940079593 drug Drugs 0.000 claims abstract description 14
- 239000002775 capsule Substances 0.000 claims abstract description 6
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 241000125175 Angelica Species 0.000 claims description 18
- 239000000843 powder Substances 0.000 claims description 8
- 230000001737 promoting effect Effects 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 238000000108 ultra-filtration Methods 0.000 claims description 5
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- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 4
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- 229960004853 betadex Drugs 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
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- 238000001914 filtration Methods 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 239000012982 microporous membrane Substances 0.000 claims description 4
- 238000001256 steam distillation Methods 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims 2
- 208000010392 Bone Fractures Diseases 0.000 abstract description 21
- 206010017076 Fracture Diseases 0.000 abstract description 20
- 206010061218 Inflammation Diseases 0.000 abstract description 5
- 230000035876 healing Effects 0.000 abstract description 5
- 230000004054 inflammatory process Effects 0.000 abstract description 5
- 230000008961 swelling Effects 0.000 abstract description 5
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- 230000001939 inductive effect Effects 0.000 description 1
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- 210000002429 large intestine Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- DKXULEFCEORBJK-UHFFFAOYSA-N magnesium;octadecanoic acid Chemical compound [Mg].CCCCCCCCCCCCCCCCCC(O)=O DKXULEFCEORBJK-UHFFFAOYSA-N 0.000 description 1
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- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The present invention relates to the medicine for the treatment of fracture, and in particular to a kind of Chinese medicine composition of promotion union, by weight ratio including following bulk drug：40~80 parts of hippocampus, 60~120 parts of Radix Angelicae Sinensis, 20~40 parts of rhizoma Gastrodiae, 60~120 parts of the root of Dahurain angelica, 50~80 parts of the coptis, 40~80 parts of radix rehmanniae recen, 20~40 parts of Herba Lycopi is prepared into capsule and tablet applications in fracture sufferer.A kind of Chinese medicine composition of promotion union of the present invention, rationally, preparation technology is simple for compatibility, and active constituent content is high, it is adaptable to which the reduction of the fracture or Post operation promote the growth of poroma, and mitigation swelling reduces inflammation, accelerates the healing rehabilitation of fracture.
Description
Technical field
The present invention relates to the medicine for the treatment of fracture, and in particular to a kind of Chinese medicine composition of promotion union.
Background technology
Fracture causes bone portion or completely fracture i.e. due to the action breaks down continuity and integrality of bone of external force.
Clinical manifestation be local pain, swelling, dysfunction, can tensioned property bubble and bleeding blister when swelling is serious.Traditional Chinese medicine is to fracture
Treatment has distinctive advantage, by reduction, fixation, functional training and necessary Chinese medicine auxiliary treatment, protects local soft group
The effect to union with human body is knitted, the slight illness of patient is relieved, with union is fast, better function, few intercurrent disease, expense
Save, without the effect of large scale equipment.
Partial fracture case is that as caused by old fracture, it is slow, long-term that growth of spur occurs after the fracture in patient mostly
The problems such as disunion, and cause the complication such as corresponding oedema, therefore lack in fracture clinical treatment and corresponding to promote fracture
The auxiliary medicaments partner treatment of healing.
The content of the invention
For defect present in prior art, it is an object of the invention to provide a kind of Chinese medicine group of promotion union
Compound, is prepared from by the processing of following Chinese medicine material medicines：Hippocampus, Radix Angelicae Sinensis, rhizoma Gastrodiae, the coptis, radix rehmanniae recen, Herba Lycopi.It is of the present invention
Chinese medicine composition compatibility rationally, in terms of fracture recovering is promoted effect significantly, non-evident effect, and it is simple to make each technique,
Active constituent content is high, it is adaptable to which the reduction of the fracture or Post operation promote the growth of poroma, mitigate swelling, reduce inflammation, plus
The healing rehabilitation of speed fracture.
To achieve the above objectives, the present invention is adopted the technical scheme that：
A kind of Chinese medicine composition of promotion union, is made up of following bulk drug by weight ratio：Hippocampus 40~80
Part, 60~120 parts of Radix Angelicae Sinensis, 20~40 parts of rhizoma Gastrodiae, 60~120 parts of the root of Dahurain angelica, 50~80 parts of the coptis, 40~80 parts of radix rehmanniae recen, Herba Lycopi
20~40 parts.
On the basis of above-mentioned technical proposal, by weight ratio including following bulk drug：
40 parts of hippocampus, 120 parts of Radix Angelicae Sinensis, 20 parts of rhizoma Gastrodiae, 100 parts of the root of Dahurain angelica, 50 parts of the coptis, 40 parts of radix rehmanniae recen, 30 parts of Herba Lycopi.
On the basis of above-mentioned technical proposal, by weight ratio including following bulk drug：
80 parts of hippocampus, 80 parts of Radix Angelicae Sinensis, 30 parts of rhizoma Gastrodiae, 120 parts of the root of Dahurain angelica, 60 parts of the coptis, 80 parts of radix rehmanniae recen, 20 parts of Herba Lycopi.
On the basis of above-mentioned technical proposal, by weight ratio including following bulk drug：
70 parts of hippocampus, 60 parts of Radix Angelicae Sinensis, 30 parts of rhizoma Gastrodiae, 80 parts of the root of Dahurain angelica, 80 parts of the coptis, 70 parts of radix rehmanniae recen, 40 parts of Herba Lycopi.
On the basis of above-mentioned technical proposal, preparation method is as follows：
Step 1, each component is weighed by weight ratio, and whole components are crushed；
Step 2, take the Radix Angelicae Sinensis crushed, the root of Dahurain angelica to use extraction by steam distillation 3 hours, obtain total volatile oil, according to weight
Ratio 1: 10 is measured, with beta-cyclodextrin inclusion compound, 100KDa milipore filter ultrafiltration obtains volatile oil-beta-schardinger dextrin solution；
Step 3, the rhizoma Gastrodiae crushed, the coptis, radix rehmanniae recen, Herba Lycopi is taken to be mixed with the dregs of a decoction in step 2, plus 10 times of amount water are returned
Stream is extracted 2 times, 1 hour every time, merges extract solution, 0.45 μm of filtering with microporous membrane, filtrate and volatile oil-β-ring in step 2
Dextrin solution merges, and is concentrated using 300~500Da of molecular cut off NF membranes, and concentrate is dried under reduced pressure, and crushes, produces；
Step 4, hippocampus is ground into fine powder with step 3 gained powder to merge, described Chinese medicine composition is made.
The formulation of Chinese medicine composition can be tablet, capsule.
Hippocampus taste is salty, sweet in Chinese medicine employed in the present invention, warm-natured, returns liver and kidney channel, cures mainly traumatic injury, Disorder lumps in the abdomen
Accumulation；Radix Angelicae Sinensis is sweet, pungent, hardship, warm-natured, Return liver, the heart, the spleen channel, there is replenishing and activating blood, swelling and pain relieving, apocenosis myogenic；Rhizoma Gastrodiae
Property sweet taste, enters Liver Channel, with Inflammation Zhijing, is used for the diseases such as hemiplegia, extremity numbness；It is radix rehmanniae recen nature and flavor sweetness and bitterness, cool, enter
The heart, liver and kidney channel, with clearing heat and cooling blood, effect of nourishing Yin and promoting production of body fluid；Root of Dahurain angelica property and flavor of peppery and warm, enters lung, spleen, stomach, stops with detumescence
Bitterly, the effect dispelled pathogenic wind and remove dampness；The coptis is bitter in taste, cold, the thoughts of returning home, stomach, liver, large intestine channel, the work(with heat-clearing and damp-drying drug, purging intense heat and detonicating
Effect, can reduce inflammation；Herba Lycopi's slightly warm in nature, bitter, pungent, Return liver the spleen channel, with promoting blood circulation and removing blood stasis, effect of line water detumescence.In this
Drug composition reuses Radix Angelicae Sinensis, hippocampus and dissipates stasis of blood myogenic, promoting blood circulation and stopping pain, while the root of Dahurain angelica, rhizoma Gastrodiae Each performs its own functions Warming Yang and promoting blood circulation, dissipating wind and stopping
Convulsion, radix rehmanniae recen heat-clearing, coptis anti-inflammatory, Herba Lycopi's inducing diuresis for removing edema, so as to reach promotion bone production, the effect reduced inflammation.According to
The principle active component of medicine in prescription, takes inclusion essential oil, extract solution ultrafiltration nanofiltration, thus retain effective thermal sensitivity into
Point, so as to reach that preparation technology is simple, active constituent content is high, convenient to adjust, and dosage is few, promotes the reduction of the fracture or Post operation
Promote the growth of poroma, accelerate the healing rehabilitation of fracture.
Embodiment
Embodiment 1：Capsule
Hippocampus 40g, Radix Angelicae Sinensis 120g, rhizoma Gastrodiae 20g, root of Dahurain angelica 100g, coptis 50g, radix rehmanniae recen 40g, Herba Lycopi 30g
Preparation technology：Each component is weighed by weight ratio, and whole components are crushed；The Radix Angelicae Sinensis crushed, the root of Dahurain angelica is taken to adopt
With extraction by steam distillation 3 hours, total volatile oil is obtained, according to weight than 1: 10, with beta-cyclodextrin inclusion compound, 100KDa milipore filters
Ultrafiltration, obtains volatile oil-beta-schardinger dextrin solution；Take the dregs of a decoction of the rhizoma Gastrodiae crushed, the coptis, radix rehmanniae recen, Herba Lycopi and the root of Dahurain angelica and Radix Angelicae Sinensis
Mix, plus 10 times are measured water refluxing extraction 2 times, 1 hour every time, merge extract solution, 0.45 μm of filtering with microporous membrane, filtrate and step
Volatile oil-beta-schardinger dextrin solution in 2 merges, and is concentrated using 300~500Da of molecular cut off NF membranes, and concentrate decompression is dry
It is dry, crush, produce；Hippocampus is ground into fine powder with above-mentioned gained powder to merge, mixed, loads hard shell capsules, by above-mentioned place
Side, every capsule 3g containing crude drug amount.
Embodiment 2：Tablet
Hippocampus 80g, Radix Angelicae Sinensis 80g, rhizoma Gastrodiae 30g, root of Dahurain angelica 120g, coptis 60g, radix rehmanniae recen 80g, Herba Lycopi 20g
Preparation technology：Each component is weighed by weight ratio, and whole components are crushed；The Radix Angelicae Sinensis crushed, the root of Dahurain angelica is taken to adopt
With extraction by steam distillation 3 hours, total volatile oil is obtained, according to weight than 1: 10, with beta-cyclodextrin inclusion compound, 100KDa milipore filters
Ultrafiltration, obtains volatile oil-beta-schardinger dextrin solution；Take the dregs of a decoction of the rhizoma Gastrodiae crushed, the coptis, radix rehmanniae recen, Herba Lycopi and the root of Dahurain angelica and Radix Angelicae Sinensis
Mix, plus 10 times are measured water refluxing extraction 2 times, 1 hour every time, merge extract solution, 0.45 μm of filtering with microporous membrane, filtrate and step
Volatile oil-beta-schardinger dextrin solution in 2 merges, and is concentrated using 300~500Da of molecular cut off NF membranes, and concentrate decompression is dry
It is dry, crush, produce；Hippocampus is ground into fine powder with above-mentioned gained powder to merge, with 200g starch, 50g dextrin and 10g stearic acid
Magnesium is mixed, and is pelletized, and drying, whole grain, tabletting is produced, every 3g containing crude drug amount.
The clinical research data of embodiment 3
Therapeutic scheme：Using the capsule, tablet prepared in Examples 1 and 2, adjunctive treatment of bone fracture is carried out, each taking 2
Grain, 3 times a day.
Applied to treatment closed fresh fracture and each 50 of closed old fracture, and the required course for the treatment of of healing is counted, seen
Table 1.
Table 1
The content for not making detailed description in this specification belongs to prior art known to professional and technical personnel in the field.
Claims (6)
1. a kind of Chinese medicine composition of promotion union, it is characterised in that be made up of by weight ratio following bulk drug：Sea
40~80 parts of horse, 60~120 parts of Radix Angelicae Sinensis, 20~40 parts of rhizoma Gastrodiae, 60~120 parts of the root of Dahurain angelica, 50~80 parts of the coptis, radix rehmanniae recen 40~80
Part, 20~40 parts of Herba Lycopi；
The preparation method of the Chinese medicine composition is as follows：
Step 1, each component is weighed by weight ratio, and whole components are crushed；
Step 2, take the Radix Angelicae Sinensis crushed, the root of Dahurain angelica to use extraction by steam distillation 3 hours, obtain total volatile oil, compare 1 according to weight
: 10, with beta-cyclodextrin inclusion compound, 100KDa milipore filter ultrafiltration obtains volatile oil-beta-schardinger dextrin solution；
Step 3, the rhizoma Gastrodiae crushed, the coptis, radix rehmanniae recen, Herba Lycopi is taken to be mixed with the dregs of a decoction in step 2, plus 10 times of amount water backflows are carried
Take 2 times, 1 hour every time, merge extract solution, 0.45 μm of filtering with microporous membrane, filtrate and volatile oil-beta-schardinger dextrin in step 2
Solution merges, and is concentrated using 300~500Da of molecular cut off NF membranes, and concentrate is dried under reduced pressure, and crushes, produces；
Step 4, hippocampus is ground into fine powder with step 3 gained powder to merge, described Chinese medicine composition is made.
2. a kind of Chinese medicine composition for promoting union as claimed in claim 1, it is characterised in that by weight ratio by
Following bulk drug composition：40 parts of hippocampus, 120 parts of Radix Angelicae Sinensis, 20 parts of rhizoma Gastrodiae, 100 parts of the root of Dahurain angelica, 50 parts of the coptis, 40 parts of radix rehmanniae recen, Herba Lycopi
30 parts.
3. a kind of Chinese medicine composition for promoting union as claimed in claim 1, it is characterised in that by weight ratio by
Following bulk drug composition：80 parts of hippocampus, 80 parts of Radix Angelicae Sinensis, 30 parts of rhizoma Gastrodiae, 120 parts of the root of Dahurain angelica, 60 parts of the coptis, 80 parts of radix rehmanniae recen, Herba Lycopi
20 parts.
4. a kind of Chinese medicine composition for promoting union as claimed in claim 1, it is characterised in that by weight ratio by
Following bulk drug composition：70 parts of hippocampus, 60 parts of Radix Angelicae Sinensis, 30 parts of rhizoma Gastrodiae, 80 parts of the root of Dahurain angelica, 80 parts of the coptis, 70 parts of radix rehmanniae recen, Herba Lycopi 40
Part.
5. Chinese medicine composition as claimed in claim 1, it is characterised in that combination dosage form is tablet.
6. Chinese medicine composition as claimed in claim 1, it is characterised in that combination dosage form is capsule.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410627736.1A CN104383298B (en) | 2014-11-07 | 2014-11-07 | A kind of Chinese medicine composition of promotion union |
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| CN1634225A (en) * | 2004-10-25 | 2005-07-06 | 杜小芳 | Medicine for reducing swelling, easing pain, promoting bone reunion and the preparation process thereof |
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| Title |
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| "中西医结合治疗严重跟骨骨折11例报道";张治;《浙江中西医结合杂志》;19941231;第4卷(第3期);第22、31页，尤其是第22页左栏倒数第3段，第31页左栏倒数第3段 * |
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