CN104042712A

CN104042712A - Stomach-soothing capsule prepared through CO2 supercritical extraction of traditional Chinese medicines and preparation method thereof

Info

Publication number: CN104042712A
Application number: CN201410214166.3A
Authority: CN
Inventors: 刘方旭; 修建东
Original assignee: YANTAI HENGDIKE ENERGY TECHNOLOGY Co Ltd
Current assignee: YANTAI HENGDIKE ENERGY TECHNOLOGY Co Ltd
Priority date: 2014-05-21
Filing date: 2014-05-21
Publication date: 2014-09-17

Abstract

The invention discloses a stomach-soothing capsule prepared through CO2 supercritical extraction of traditional Chinese medicines and a preparation method thereof. The stomach-soothing capsule comprises the following raw materials: cuttlefish bone, prepared rhizoma corydalis, Radix Astragali, inner membrane of chicken gizzard, prepared bighead atractylodes rhizome, polyporus, dark plum and rhubarb root and rhizome. The stomach-soothing capsule is prepared through material preparation, extraction, granulation, sterilization and packaging. Due to supercritical carbon dioxide extraction of effective components in the raw materials, the method has the advantages of a high recovery rate, low operation temperature, no destroy to effective components in the traditional Chinese medicines, no residual of organic solvents and simple process; the prepared capsule can be directly taken in use and carried with one, is convenient to store, omits the process of decoction for decoctum, eliminates unique peculiar smell and adverse stimulation of traditional Chinese medicine decoctum during administration, exerts center warming, cold dispelling, qi benefiting, spleen invigorating, qi rectifying and pain relieving effects, can realize isolation protection on gastric mucosae and strengthen the recovery effect of gastric mucosae and has blood circulation promoting, anti-inflammatory and haemostatic effects.

Description

A kind of CO 2supercritical extraction Chinese drug preparation Shuwei Capsules and preparation method thereof

Technical field

The present invention relates to the technical field of Chinese medicinal ointment, espespecially a kind of CO ₂supercritical extraction Chinese drug preparation Shuwei Capsules and preparation method thereof.

Background technology

Gastropathy is a kind of multi-pathogenesis disease, such as heredity, be generally bad living habit and psychentonia and cause the digestive and absorptive functions of the intestines and stomach to reduce, produces the symptoms such as belch gas, pantothenic acid, stomachache, burning sensation.Patient have intermittence or persistence upper abdomen dull pain or occasionally has severe pain and discomfort, feels sick, vomiting, acid regurgitation, the digestive symptoms such as heartburn.

With Western medicine comparison, treatment by Chinese herbs takes effect slow, but Chinese medicine can regulate human-body viscera function, improves body immunity, thereby repairs impaired tissue; So with respect to Western medicine, herbal toxic effect is less, when treatment, can not injure the organ such as liver, kidney, can not produce drug resistance and Drug resistance to human body.

Decoct and could extract medicinal ingredient but treatment by Chinese herbs need to add water decoction while taking, not only the amount of drinking is greatly also very loaded down with trivial details, causes many inconvenience to patient; And adopt extracting of traditional method, and can not extract Effective Component of Chinese Medicine completely, the effective ingredient of manufacturing in Chinese medicine runs off.

Summary of the invention

A kind of CO of the present invention ₂supercritical extraction Chinese drug preparation Shuwei Capsules and preparation method thereof, can solve the deficiency of above-mentioned technology, adopts CO ₂the effective elements of the medicine in supercritical extraction, realizes object safe, that prepare efficiently, easily Shuwei Capsules.

To achieve these goals, technical solution of the present invention is: a kind of CO ₂the raw material components of supercritical extraction Chinese drug preparation Shuwei Capsules and preparation method thereof: Os Sepiae 140 ㎏～150 ㎏, Rhizoma Corydalis processed 40 ㎏～50 ㎏, the Radix Astragali 40 ㎏～50 ㎏, Endothelium Corneum Gigeriae Galli 140 ㎏～150 ㎏, the Rhizoma Atractylodis Macrocephalae processed 40 ㎏～50 ㎏, Polyporus 40 ㎏～50 ㎏, Fructus Mume 40 ㎏～50 ㎏, Radix Et Rhizoma Rhei 4 ㎏～5 ㎏.

Technique preparation process is as follows:

(1) get the raw materials ready: by raw material components remove impurity, pulverize, cross 60 mesh sieves, extracting screen underflow, obtains mixed powder;

(2) extraction: adopt supercritical extracting equipment device, mixed powder is put into supercritical CO ₂in the extraction kettle of extraction equipment, adding entrainer content is 60% ethanol submergence mixed powder, with supercritical CO ₂for extractant, 30 DEG C～50 DEG C of extraction temperature, extracting pressure 15Mpa～30Mpa, extraction time is 4h～6h, then adopts intensification, blood pressure lowering to separate, and collects product in separating still and must extract powder;

(3) granulate: extraction powder is added in capsule loading machine, to make every quality be 0.5g Chinese medicine Shuwei Capsules;

(4) sterilization packaging: the agent of Chinese medicine Shuwei Capsules is inserted and irradiated after 20min packaging in time under ultraviolet.

The present invention adopts supercritical carbon dioxide extraction raw material components effective ingredient can be extracted completely, step is simple, save cost, simultaneously compared with traditional method, have that extraction ratio is high, operative temperature is low, Effective Component of Chinese Medicine is not destroyed, organic solvent-free is residual and the simple advantage of technique; Distinctive abnormal flavour and pessimal stimulation etc. while taking that manufactured goods can instantly take, store conveniently, can carry, saved decoct decoction process, eliminated Chinese herbs decoction.

Shuwei Capsules of the present invention has effect of warming spleen and stomach for dispelling cold, replenishing QI to invigorate the spleen, regulating QI to relieve pain; Can insulation blocking gastric mucosa and strengthen the repair of gastric mucosa, also have simultaneously increase invigorate blood circulation, the effect of antiinflammatory, hemostasis; The clinical weakness of the spleen and stomach that can be used for, tired weak and the intermittent or persistence upper abdomen dull pain of gastralgia, belch acid regurgitation, body due to deficiency-cold in middle-JIAO or occasionally have severe pain and discomfort, feel sick, vomiting, acid regurgitation, the digestive symptoms person such as heartburn.

Detailed description of the invention

Embodiment 1

(1) raw material components: Os Sepiae 150 ㎏, Rhizoma Corydalis processed 50 ㎏, the Radix Astragali 50 ㎏, Endothelium Corneum Gigeriae Galli 150 ㎏, the Rhizoma Atractylodis Macrocephalae processed 50 ㎏, Polyporus 50 ㎏, Fructus Mume 50 ㎏, Radix Et Rhizoma Rhei 5 ㎏.

(2) technique preparation process is as follows:

1. get the raw materials ready: by raw material components remove impurity, pulverize, cross 60 mesh sieves, extracting screen underflow, obtains mixed powder;

2. extraction: adopt supercritical extracting equipment device, mixed powder is put into supercritical CO ₂in the extraction kettle of extraction equipment, adding entrainer content is 60% ethanol submergence mixed powder, with supercritical CO ₂for extractant, 30 DEG C of extraction temperature, extracting pressure 30Mpa, extraction time is 6h, then adopts intensification, blood pressure lowering to separate, and collects product in separating still and must extract powder;

Embodiment 2

(1) raw material components: Os Sepiae 140 ㎏, Rhizoma Corydalis processed 40 ㎏, the Radix Astragali 40 ㎏, Endothelium Corneum Gigeriae Galli 140 ㎏, the Rhizoma Atractylodis Macrocephalae processed 40 ㎏, Polyporus 40 ㎏, Fructus Mume 40 ㎏, Radix Et Rhizoma Rhei 4 ㎏.

(2) technique preparation process is as follows:

2. extraction: adopt supercritical extracting equipment device, mixed powder is put into supercritical CO ₂in the extraction kettle of extraction equipment, adding entrainer content is 60% ethanol submergence mixed powder, with supercritical CO ₂for extractant, 50 DEG C of extraction temperature, extracting pressure 15Mpa, extraction time is 4h, then adopts intensification, blood pressure lowering to separate, and collects product in separating still and must extract powder;

Embodiment 3

(1) raw material components: Os Sepiae 15 ㎏, Rhizoma Corydalis processed 45 ㎏, the Radix Astragali 45 ㎏, Endothelium Corneum Gigeriae Galli 145 ㎏, the Rhizoma Atractylodis Macrocephalae processed 45 ㎏, Polyporus 45 ㎏, Fructus Mume 45 ㎏, Radix Et Rhizoma Rhei 4.5 ㎏.

(2) technique preparation process is as follows:

2. extraction: adopt supercritical extracting equipment device, mixed powder is put into supercritical CO ₂in the extraction kettle of extraction equipment, adding entrainer content is 60% ethanol submergence mixed powder, with supercritical CO ₂for extractant, 40 DEG C of extraction temperature, extracting pressure 20Mpa, extraction time is 5h, then adopts intensification, blood pressure lowering to separate, and collects product in separating still and must extract powder;

The above; embodiment is only that the preferred embodiment of the present invention is described; not scope of the present invention is limited; under the prerequisite of spirit that does not depart from the technology of the present invention; various distortion and improvement that this area engineers and technicians make technical scheme of the present invention, all should fall in the definite protection domain of claims of the present invention.

Claims

1. a CO ₂supercritical extraction Chinese drug preparation Shuwei Capsules and preparation method thereof, is characterized in that: raw material components: Os Sepiae 140 ㎏～150 ㎏, Rhizoma Corydalis processed 40 ㎏～50 ㎏, the Radix Astragali 40 ㎏～50 ㎏, Endothelium Corneum Gigeriae Galli 140 ㎏～150 ㎏, the Rhizoma Atractylodis Macrocephalae processed 40 ㎏～50 ㎏, Polyporus 40 ㎏～50 ㎏, Fructus Mume 40 ㎏～50 ㎏, Radix Et Rhizoma Rhei 4 ㎏～5 ㎏.

2. technique preparation process is as follows:

3. a kind of traditional Chinese medicine capable of reducing weight dissolved granule according to claim 1 and preparation method thereof, is characterized in that: technique preparation process is as follows:

(1) lixiviate: by the remove impurity of major ingredient component, cleaning, put in interlayer lixiviate pot, temperature 70 C～80 DEG C add 8 times of water gagings, and lixiviate 2h gets lixiviating solution and deposits; Add 8 times of water gagings, temperature 70 C～80 DEG C lixiviate 1h, merges twice decoction liquor again, with 100 mesh sieves filtrations;

(2) concentrate drying: filtrate is inserted in vacuum concentration pan, sets 55 DEG C～70 DEG C of vacuum 97kPa, temperature, is condensed into concentrated solution, and concentrated solution is 25% of major ingredient component, then concentrated solution is dry through spraying, obtains lixiviate powder;

(3) soft material: lixiviate powder 20% adds in kneader, then add cane sugar powder, dextrin, is modulated to soft material with the ethanol of content 50%

(4) granulate: adopt 16 mesh sieves to push sieve series granule;

(5) dry: the shape granule that will wet is inserted 60 DEG C of drying baker inner drying 3h, and every 0.5h stirs once, accelerate rate of drying;

(6) granulate: by dried granule after 1 10 mesh sieve granulate;

(7) sterilization packaging: granule is inserted and irradiated after 20min packaging in time under ultraviolet.