CN103784918A - Medicine composition for treating regurgitation-induced quidding of equus animals - Google Patents
Medicine composition for treating regurgitation-induced quidding of equus animals Download PDFInfo
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Abstract
The invention provides a medicine composition for treating regurgitation-induced quidding of equus animals. The medicine composition comprises the following raw medicines: dangshen, dried ginger, atractylodes macrocephala, fructus amomi rotundus, rhizoma pinelliae, fructus amomi and medicated leaven. The medicine composition has the beneficial effects that the medicine composition takes warming middle-jiao and tonifying the spleen and harmonizing the stomach for descending adverse qi as the treatment principles, has reasonable components, has simple preparation processes and has a wide range of application; the medicine composition is prepared from pure Chinese herbal medicines, has a wide source, is low in cost, has a high cure rate and does not have medicine residues or toxic or side effect; in particular, plant cell walls are furthest destroyed after superfine grinding, thus overcoming the defects that traditional medicine powder has high content of crude fibers and active ingredients are hard to dissolve out and being easier to absorb by horses; the medicine composition has obvious functions of warming middle-jiao and tonifying the spleen and adjusting body functions, effectively treats regurgitation-induced quidding of equus animals and can shorten the recovery phase and avoid relapse compared with western medicines.
Description
Technical field
The present invention relates to technology of pharmaceutical engineering field, relate in particular to and a kind ofly treat equus regurgitation and tell careless drug regimen.
Background technology
Regurgitation is the disease that after food, vexed swollen, the indigestion of gastral cavity abdomen, eating in the morning but vomiting out in the evening, vomiting out in the morning what eaten at last night are main clinical manifestation.How to be hindered by eating and drinking without temperance, wine and women-sensual pursuits, or long-term anxiety and rage, make spleen and stomach function impaired, so that the stagnation of QI, blood stasis, expectorant is solidifying forms.Claim again regurgitation, regurgitation of food from the stomach.The Clinical symptoms that regurgitation is recorded in Han dynasty " Medical Treasures of the Golden Chamber " is " eating in the morning but vomiting out in the evening, vomiting out in the morning what eaten at last night, indigested food stagnated in the stomach ", and proposes specifically to demonstrate,prove and control.The Tang Dynasty Wang Bing thinks that in " Plain Questions " explanatory notes this sick pathogenesis is without fire, makes taste be difficult digesting food.Yuan Dynasty's " danxi's experiential therapy " thinks that the pathogenesis of regurgitation is blood deficiency, the deficiency of vital energy, has heat, has expectorant.Saying of benefit gate of vitality's fire in Ming Dynasty's Jing-Yue Complete Works is the important supplement to this sick treatment.The peptic ulcer of doctor trained in Western medicine, Stomach duodenum diverticulum, acute and chronic gastritis, prolapse of gastric mucosa, duodenum is stopped up stagnant disease, gastric tumor, stomach neurosis etc., all concurrent stomachus pyloricus spasm, edema, narrow, cause gastric emptying disorder, there is regurgitation symptom, all can be with reference to this sick content determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.The generation of regurgitation, is mainly accumulated heat in Deficiency and coldness of spleen and stomach, stomach, the turbid resistance stomach of expectorant or obstruction of collaterals by blood stasis etc., affects that gastric qi is logical falls row, and indigestion forms.
Now, if only use western medicine, not only toxic and side effects is larger, and unsatisfactory curative effect.And adopt pure herbal treatment, not only healing period is short, and toxic and side effects is little and difficult recurrence.
Summary of the invention
Technical problem to be solved by this invention is, overcome prior art provide a kind of effective reduction toxic and side effects, effectively treat equus regurgitation tell convalescent period after grass and treatment short, drug residue free and the treatment equus regurgitation of toxic and side effects tell careless drug regimen.
In order to solve the problems of the technologies described above, the invention provides and a kind ofly treat equus regurgitation and tell careless drug regimen, described Chinese medicine composition comprises following raw medicinal material: Radix Codonopsis, Rhizoma Zingiberis, the Rhizoma Atractylodis Macrocephalae, roud cardamon seed, Rhizoma Pinelliae Preparatum, Fructus Amomi and Massa Medicata Fermentata.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine composition is preferably, 20～30 parts of 20～30 parts of Radix Codonopsis, 15～25 parts of Rhizoma Zingiberiss, 15～25 parts of the Rhizoma Atractylodis Macrocephalaes, 15～25 parts of roud cardamon seeds, 7～15 parts of Rhizoma Pinelliae Preparatum, 7～15 parts of Fructus Amomis and Massa Medicata Fermentata.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine composition can also be, 24～26 parts of 24～26 parts of Radix Codonopsis, 19～21 parts of Rhizoma Zingiberiss, 19～21 parts of the Rhizoma Atractylodis Macrocephalaes, 19～21 parts of roud cardamon seeds, 9～11 parts of Rhizoma Pinelliae Preparatum, 9～11 parts of Fructus Amomis and Massa Medicata Fermentata.
The ratio of weight and number of the kind raw medicinal material in described Chinese medicine composition also can be preferably, 25 parts of 25 parts of Radix Codonopsis, 20 parts of Rhizoma Zingiberiss, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of roud cardamon seeds, 10 parts of Rhizoma Pinelliae Preparatum, 10 parts of Fructus Amomis and Massa Medicata Fermentata.
Described Chinese medicine composition can further include Fructus Evodiae, and the ratio of weight and number of described Fructus Evodiae is 15～20 parts.Be preferably 18 parts.
Described Chinese medicine composition can further include Folium Eriobotryae, Radix Glycyrrhizae, Rhizoma Coptidis and Radix Scutellariae, and ratio of weight and number is respectively Folium Eriobotryae 15-20 part, 15～20 parts, Radix Glycyrrhizae, Rhizoma Coptidis 8-15 part and Rhizoma Atractylodis Macrocephalae 10-15 part.Be preferably 12 parts of 16 parts of Folium Eriobotryaes, 16 parts, Radix Glycyrrhizae, 10 parts of Rhizoma Coptidis and Radix Scutellariaes.
The preparation method that the present invention also provides above-mentioned any one treatment equus regurgitation to tell careless drug regimen, the preparation method of described Chinese medicine composition is,
Step 1: take various raw medicinal materials according to percentage by weight, mix, be ground into powder, granularity is 20-200 order;
Step 2: to the yellow wine that adds 90 ~ 110 parts in the powder of step 1, mix homogeneously.
Wherein, the granularity in described step 1 is preferably 150-200 order.
The preparation method that the present invention provides again above-mentioned any one treatment equus regurgitation to tell careless drug regimen, the preparation method of described Chinese medicine composition comprises the following steps,
The first step, is mixed in proportion described component, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;
The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of powder quality that second step obtains;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 20～200 orders;
The 5th step, to the yellow wine that adds 90 ~ 110 parts in the powder of the 4th step, mix homogeneously.
Wherein, the granularity in described the 5th step is preferably 150-200 order.
Wherein, the unit of above-mentioned various raw medicinal materials " part " is preferably " g ", and the unit " part " of yellow wine is preferably " ml ".
Beneficial effect of the present invention: the present invention is with warming middle-JIAO and strengthening the spleen, and regulating the stomach and sending down the abnormal ascending QI is the rule for the treatment of, reasonable recipe, preparation technology is simple, applied widely.The present invention adopts pure Chinese medicinal herbs to make, wide material sources, cost are low, cure rate is high, medicine noresidue, have no side effect, particularly after micronizing, destroy to greatest extent plant cell wall, solved the deficiency that traditional drugs powder crude fiber content is high, effective ingredient is difficult to stripping, be easier to horses and absorb.There is the effect of significant anti-inflammation and stopping pain and adjusting body function, effectively treat equus regurgitation and tell grass, shorten the period of convalescence with western medicine phase specific energy, and do not recur.
The specific embodiment
The invention provides and a kind ofly treat equus regurgitation and tell careless drug regimen, described Chinese medicine composition comprises following raw medicinal material: Radix Codonopsis, Rhizoma Zingiberis, the Rhizoma Atractylodis Macrocephalae, roud cardamon seed, Rhizoma Pinelliae Preparatum, Fructus Amomi and Massa Medicata Fermentata.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine composition is preferably, 20～30 parts of 20～30 parts of Radix Codonopsis, 15～25 parts of Rhizoma Zingiberiss, 15～25 parts of the Rhizoma Atractylodis Macrocephalaes, 15～25 parts of roud cardamon seeds, 7～15 parts of Rhizoma Pinelliae Preparatum, 7～15 parts of Fructus Amomis and Massa Medicata Fermentata.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine composition can also be, 24～26 parts of 24～26 parts of Radix Codonopsis, 19～21 parts of Rhizoma Zingiberiss, 19～21 parts of the Rhizoma Atractylodis Macrocephalaes, 19～21 parts of roud cardamon seeds, 9～11 parts of Rhizoma Pinelliae Preparatum, 9～11 parts of Fructus Amomis and Massa Medicata Fermentata.
The ratio of weight and number of the kind raw medicinal material in described Chinese medicine composition also can be preferably, 25 parts of 25 parts of Radix Codonopsis, 20 parts of Rhizoma Zingiberiss, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of roud cardamon seeds, 10 parts of Rhizoma Pinelliae Preparatum, 10 parts of Fructus Amomis and Massa Medicata Fermentata.
Described Chinese medicine composition can further include Fructus Evodiae, and the ratio of weight and number of described Fructus Evodiae is 15～20 parts.Be preferably 18 parts.
Described Chinese medicine composition can further include Folium Eriobotryae, Radix Glycyrrhizae, Rhizoma Coptidis and Radix Scutellariae, and ratio of weight and number is respectively Folium Eriobotryae 15-20 part, 15～20 parts, Radix Glycyrrhizae, Rhizoma Coptidis 8-15 part and Rhizoma Atractylodis Macrocephalae 10-15 part.Be preferably 12 parts of 16 parts of Folium Eriobotryaes, 16 parts, Radix Glycyrrhizae, 10 parts of Rhizoma Coptidis and Radix Scutellariaes.
The preparation method that the present invention also provides above-mentioned any one treatment equus regurgitation to tell careless drug regimen, the preparation method of described Chinese medicine composition is,
Step 1: take various raw medicinal materials according to percentage by weight, mix, be ground into powder, granularity is 20-200 order;
Step 2: to the yellow wine that adds 90 ~ 110 parts in the powder of step 1, mix homogeneously.
Granularity in described step 1 is preferably 150-200 order.
The preparation method that the present invention provides again above-mentioned any one treatment equus regurgitation to tell careless drug regimen, the preparation method of described Chinese medicine composition comprises the following steps,
The first step, is mixed in proportion described component, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;
The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of powder quality that second step obtains;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 20～200 orders;
The 5th step, to the yellow wine that adds 90 ~ 110 parts in the powder of the 4th step, mix homogeneously.
Granularity in described the 5th step is preferably 150-200 order.
The pharmacology of described each component is as follows:
Radix Codonopsis: Shangdang Radix Ginseng, Radix Saposhnikoviae Radix Codonopsis, Sphallerocarpus gracilis, preventing lanceolata, upper Radix Codonopsis, SHITOUSEN, middle Ganoderma, yellow party, middle Ganoderma, informal voucher Radix Codonopsis, property is flat, sweet in the mouth, micro-acid.Return spleen, lung meridian, cure mainly invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.
Rhizoma Zingiberis: the dry rhizome of zingiber ,] acrid in the mouth, hot in nature.Return spleen, stomach, the heart, lung meridian, can warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention, coldness and pain in the epigastrium, vomit, have loose bowels, YANG-depletion faint contrary, cold fluid-retention is breathed with cough, arthralgia due to cold-dampnes.
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, the cards such as frequent fetal movement; The effects such as the Rhizoma Atractylodis Macrocephalae has the gastrointestinal motility function of adjustment, antiulcer, protects the liver, enhancing human body immunity function, anti-stress, enhancing hemopoietic function; Its dampness diuretic effect is relevant with diuresis; And antiabortive effect is relevant with the effect of inhibition uterine contraction.The Rhizoma Atractylodis Macrocephalae also has the effects such as antioxidation, slow down aging, blood sugar lowering, anticoagulation, antitumor.
Roud cardamon seed: claim again Fructus Amomi Rotundus, Fructus Amomi Rotundus.For the fruit of Zingiberaceae herbaceos perennial Fructus Amomi Rotundus, 10 1 December fruits are yellow green, while not yet cracking, take, remove residual fruit stem dry do medicinal.Getting clean Fructus Amomi Rotundus, remove impurity and shell, get clean core, is Semen Vignae Cylindricae KOUREN, gets clean Fructus Amomi Rotundus, removes impurity.Stripping peel, is Fructus Amomi Rotundus skin.Property and flavor of peppery and warm.There is regulating the flow of QI to ease the stomach, dry cold-damp, effect of alcoholic intoxication.The disease such as abdominal distention, eructation regurgitation of can treating for stomachache.
Rhizoma Pinelliae Preparatum: Rhizoma Pinelliae Preparata, method for making summer, system ground literary composition, system ground eight beans, nature and flavor: pungent, warm, return spleen, stomach, lung meridian, cure mainly for dry laryngopharynx abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache.
Fructus Amomi: acrid in the mouth, warm in nature, return spleen channel, stomach warp, kidney channel, can removing dampness whet the appetite, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive, for turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
Massa Medicata Fermentata: for after the medicines such as Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum add flour or wheat bran mixed, the herbal leaven forming through fermentation, sweet in the mouth is pungent, warm in nature, nontoxic, enter spleen, stomach warp, can invigorating the spleen and regulating the stomach, in helping digestion and adjusting, cure mainly retention of food and drink, feeling of stuffiness in chest abdominal distention, vomiting dysentery, postnatal blood stasis stomachache, children's's enlarged abdomen is hard long-pending.
Yellow wine: be field of medicaments, particularly very important adjuvant or " extra conductant ingredient " in the field of Chinese medicines.Help blood circulation, enhance metabolism, there is blood-enriching face-nourishing, the effect of the cold relieving of invigorating blood circulation, dredge the meridian passage, effectively the cold resisting stimulation, preventing cold.
Fructus Evodiae: another name Koji, volt spicy, smelly lake, Fructus Evodiae, tea are peppery, paint spicy, smelly spicy tree, the deep and remote son of Zuo Lichun, rice spicy etc.Acrid in the mouth, hardship, hot in nature; Slightly poisonous.Return liver, spleen, stomach, kidney channel.Dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For headache due to JUE YIN disorder, colic of cold type stomachache, the disturbance of lower legs due to pathogenic cold and dampness, dysmenorrhea, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea, external treatment aphtha; Hypertension.
Folium Eriobotryae: another name rake leaf, Lu Juye, Ba Ye, bitter in the mouth, cold nature, returns lung, and stomach warp, cures mainly clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.Cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastropyretic vomiting, hiccup.Can treat xerostomia and quench one's thirst, lung-wind syndrome acne vulgaris, acne.
Radix Glycyrrhizae: a kind of tonification Chinese herbal medicine.Medicinal part is root and rhizome, and Medicinal Materials Characters root is cylindrical, long 25～l00cm, diameter 0.6～3.5cm.Crust degree of tightness differs, the brown or taupe brown of surface red.Rhizome is cylindrical, and there is bud trace on surface, and there is marrow at section middle part.Feeble QI, taste is sweet and special.Function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc.Happiness sunlight is abundant, the low dry climate of long temperature at sunshine.Radix Glycyrrhizae is grown in arid, semiarid desert steppe, desert edge and loess hill area more.
Rhizoma Coptidis: bitter in the mouth, cold in nature, GUIXIN, liver, stomach, large intestine channel, matter heavily fortified point is rich, falls and microlitre; There is clearing away heat-fire, dampness, effect of removing toxic substances.Cure mainly the burning hot second of calentura, high heat is irritated, unconsciousness and delirium; Hyperactivity of heart-fire, chest and diaphragm heat is vexed, vexed insomnia, aphtha of the mouth and tongue; Bleeding due to blood-heat, spits blood, clot blood; Liver-fire conjunctival congestion and swelling pain; Gastropyretic vomiting, quenches one's thirst, gingival swelling and pain; The intestines and stomach is damp and hot, and gastral cavity abdomen feeling of fullness, has loose bowels, dysentery; Pathopyretic ulcer, eczema, scalds.
Radix Scutellariae: another name Radix Scutellariae, tsuchikane tea root.Radix Scutellariae (Scutellaria baicalensis Georgi) is a kind of plant of Labiatae Scutellaria, belongs to half kind kind of semi-wild, herbaceos perennial.The root of Radix Scutellariae is a kind of medical herbs, bitter in the mouth, cold in nature, energy heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1:
Radix Codonopsis 25g, Rhizoma Zingiberis 20g, Rhizoma Atractylodis Macrocephalae 20g, roud cardamon seed 20g, Rhizoma Pinelliae Preparatum 10g, Fructus Amomi 10g and Massa Medicata Fermentata 25g.Mix, be ground into powder, granularity is 200 orders; In powder, add 100ml yellow wine, mix homogeneously.When use, gavage.
Embodiment 2:
Radix Codonopsis 24g, Rhizoma Zingiberis 19g, Rhizoma Atractylodis Macrocephalae 19g, roud cardamon seed 20g, Rhizoma Pinelliae Preparatum 9g, Fructus Amomi 9g, Massa Medicata Fermentata 24g and Fructus Evodiae 18g.Mix, be ground into powder, granularity is 180 orders; In powder, add 90ml yellow wine, mix homogeneously.When use, gavage.
Embodiment 3:
Radix Codonopsis 26g, Rhizoma Zingiberis 21g, Rhizoma Atractylodis Macrocephalae 21g, roud cardamon seed 19g, Rhizoma Pinelliae Preparatum 10g, Fructus Amomi 11g, Massa Medicata Fermentata 26g, Folium Eriobotryae 16g, Radix Glycyrrhizae 16g, Rhizoma Coptidis 10g and Rhizoma Atractylodis Macrocephalae 12g.Preparation method comprises the following steps:
The first step, is mixed in proportion various raw medicinal materials, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 10 hours, and with slow fire boiling, decocting time is 4 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 4 times of the powder quality that obtains of the first step;
The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 3 hours, filters and obtains the second filtrate, and the quality of the water adding is 3 times of powder quality that second step obtains;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 150 orders;
The 5th step, to the yellow wine that adds 100ml in the powder of the 4th step, mix homogeneously.
When use, gavage.
Embodiment 4:
Radix Codonopsis 26g, Rhizoma Zingiberis 19g, Rhizoma Atractylodis Macrocephalae 20g, roud cardamon seed 21g, Rhizoma Pinelliae Preparatum 11g, Fructus Amomi 10g, Massa Medicata Fermentata 25g, Fructus Evodiae 20g, Folium Eriobotryae 18g, Radix Glycyrrhizae 20g, Rhizoma Coptidis 12g and Rhizoma Atractylodis Macrocephalae 10g.Preparation method comprises the following steps:
The first step, is mixed in proportion various raw medicinal materials, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 8 hours, and with slow fire boiling, decocting time is 5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 3 times of the powder quality that obtains of the first step;
The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 4 hours, filters and obtains the second filtrate, and the quality of the water adding is 4 times of powder quality that second step obtains;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 200 orders;
The 5th step, to the yellow wine that adds 110ml in the powder of the 4th step, mix homogeneously.
When use, gavage.
Acute toxicity test:
120 of application NIH mices, SPF level, male and female half and half, body weight 18～22g, carries out acute toxicity testing.Mice is divided into three groups at random, be that (concentration is 6.28g crude drug/ml for the Chinese medicine composition of matched group, the administration embodiment of the present invention 1, maximum concentration) administration group 1 and the administration embodiment of the present invention 4 (concentration is 6.28g crude drug/ml, maximum concentration) the administration group 2 of Chinese medicine composition, fasting 12 hours before experiment.The Chinese medicinal powder that administration group 1 and administration group 2 are prepared embodiments of the invention 1 and embodiment 4 is respectively dissolved in water mouse stomach, gavage volume is 5ml/kg (being that single-dose dosage is 31.4g crude drug/kg), matched group gives equivalent normal saline, administration in 1 day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, mice overall health of patients, ingest, drinking-water, body weight gain is all normal.Therefore Chinese medicine acute toxicity of the present invention is low, clinical drug safety.
Clinical trial:
Chinese medicine composition avirulence of the present invention, easy to use, can directly gavage or add in feedstuff and use.When application, Chinese medicine composition of the present invention directly can be gavaged by per kilogram of body weight 0.4g crude drug, or mix in feedstuff and feed and suffer from poultry, and statistical data demonstration, generally can fully recover for the continuous 2-5 of taking days, and treatment time is short, clinical cure rate reaches 95%, and cure rate is high.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (10)
1. treat equus regurgitation and tell a careless drug regimen, it is characterized in that, described Chinese medicine composition comprises following raw medicinal material: Radix Codonopsis, Rhizoma Zingiberis, the Rhizoma Atractylodis Macrocephalae, roud cardamon seed, Rhizoma Pinelliae Preparatum, Fructus Amomi and Massa Medicata Fermentata.
2. careless drug regimen is told in treatment equus as claimed in claim 1 regurgitation, it is characterized in that: the ratio of weight and number of the various raw medicinal materials in described Chinese medicine composition is 20～30 parts of 20～30 parts of Radix Codonopsis, 15～25 parts of Rhizoma Zingiberiss, 15～25 parts of the Rhizoma Atractylodis Macrocephalaes, 15～25 parts of roud cardamon seeds, 7～15 parts of Rhizoma Pinelliae Preparatum, 7～15 parts of Fructus Amomis and Massa Medicata Fermentata.
3. careless drug regimen is told in treatment equus as claimed in claim 1 or 2 regurgitation, it is characterized in that: the ratio of weight and number of the various raw medicinal materials in described Chinese medicine composition is 24～26 parts of 24～26 parts of Radix Codonopsis, 19～21 parts of Rhizoma Zingiberiss, 19～21 parts of the Rhizoma Atractylodis Macrocephalaes, 19～21 parts of roud cardamon seeds, 9～11 parts of Rhizoma Pinelliae Preparatum, 9～11 parts of Fructus Amomis and Massa Medicata Fermentata.
4. careless drug regimen is told in the treatment equus regurgitation as described in claims 1 to 3, it is characterized in that: the ratio of weight and number of the kind raw medicinal material in described Chinese medicine composition is 25 parts of 25 parts of Radix Codonopsis, 20 parts of Rhizoma Zingiberiss, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of roud cardamon seeds, 10 parts of Rhizoma Pinelliae Preparatum, 10 parts of Fructus Amomis and Massa Medicata Fermentata.
5. careless drug regimen is told in the treatment equus regurgitation as described in claim 1 to 4, it is characterized in that: described Chinese medicine composition also further comprises Fructus Evodiae, and the ratio of weight and number of described Fructus Evodiae is 15～20 parts.
6. careless drug regimen is told in the treatment equus regurgitation as described in claim 1 to 5, it is characterized in that: described Chinese medicine composition also further comprises Folium Eriobotryae, Radix Glycyrrhizae, Rhizoma Coptidis and Radix Scutellariae, ratio of weight and number is respectively Folium Eriobotryae 15-20 part, 15～20 parts, Radix Glycyrrhizae, Rhizoma Coptidis 8-15 part and Radix Scutellariae 10-15 part.
7. careless drug regimen is told in the treatment equus regurgitation as described in claim 1 to 6, it is characterized in that: the preparation method of described Chinese medicine composition is,
Step 1: take various raw medicinal materials according to percentage by weight, mix, be ground into powder, granularity is 20-200 order;
Step 2: to the yellow wine that adds 90 ~ 110 parts in the powder of step 1, mix homogeneously.
8. careless drug regimen is told in treatment equus as claimed in claim 7 regurgitation, it is characterized in that: the granularity in described step 1 is 150-200 order.
9. careless drug regimen is told in the treatment equus regurgitation as described in claim 1 to 6, it is characterized in that:
The preparation method of described Chinese medicine composition comprises the following steps,
The first step, is mixed in proportion described component, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;
The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of powder quality that second step obtains;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 20～200 orders;
The 5th step, to the yellow wine that adds 90 ~ 110 parts in the powder of the 4th step, mix homogeneously.
10. careless drug regimen is told in treatment equus as claimed in claim 9 regurgitation, it is characterized in that: the granularity in described the 5th step is 150-200 order.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189276A (en) * | 2014-08-24 | 2014-12-10 | 严中明 | Drug for treating regurgitation and grass vomit caused by osteomalacia |
| CN104208467A (en) * | 2014-08-24 | 2014-12-17 | 严中明 | Traditional Chinese medicine composition for treating stomach-heat-induced regurgitation and grass vomit of cattle and horses |
| CN105521471A (en) * | 2015-12-21 | 2016-04-27 | 天农大（天津）生物科技有限公司 | Traditional Chinese medicine composition for treating horse nausea quidding and preparing method thereof |
| CN104189232B (en) * | 2014-08-24 | 2016-10-05 | 严中明 | A kind of treat oxen and horses impairment caused by overstrain regurgitation tell grass compositions |
-
2013
- 2013-12-14 CN CN201310678273.7A patent/CN103784918A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189276A (en) * | 2014-08-24 | 2014-12-10 | 严中明 | Drug for treating regurgitation and grass vomit caused by osteomalacia |
| CN104208467A (en) * | 2014-08-24 | 2014-12-17 | 严中明 | Traditional Chinese medicine composition for treating stomach-heat-induced regurgitation and grass vomit of cattle and horses |
| CN104189232B (en) * | 2014-08-24 | 2016-10-05 | 严中明 | A kind of treat oxen and horses impairment caused by overstrain regurgitation tell grass compositions |
| CN105521471A (en) * | 2015-12-21 | 2016-04-27 | 天农大（天津）生物科技有限公司 | Traditional Chinese medicine composition for treating horse nausea quidding and preparing method thereof |
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