CN103784652A - Medicine composition for treating gastroenteritis of equus animals - Google Patents
Medicine composition for treating gastroenteritis of equus animals Download PDFInfo
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Abstract
The invention provides a medicine composition for treating gastroenteritis of equus animals. The medicine composition comprises the following raw medicines: parched hawthorn fruit, medicated leaven, processed rhizoma pinelliae, Indian bread, dried tangerine peel, radish seed and areca peel. The medicine composition has the beneficial effects that the medicine composition takes warming the spleen and stomach for dispelling cold and benefiting qi and raising Yang as the treatment principles, has reasonable components, has simple preparation processes and has a wide range of application; the medicine composition is prepared from pure Chinese herbal medicines, has a wide source, is low in cost, has a high cure rate and does not have medicine residues or toxic or side effect; in particular, plant cell walls are furthest destroyed after superfine grinding, thus overcoming the defects that traditional medicine powder has high content of crude fibers and active ingredients are hard to dissolve out and being easier to absorb by horses; the medicine composition has obvious functions of diminishing inflammation to remove pains and adjusting body functions, effectively treats gastroenteritis of equus animals and can shorten the recovery phase and avoid relapse compared with western medicines.
Description
Technical field
The present invention relates to technology of pharmaceutical engineering field, relate in particular to a kind of drug regimen for the treatment of equus gastroenteritis.
Background technology
Gastroenteritis is gastric mucosa and intestinal mucosa inflammation, is caused by alimentary toxicosis.Symptom comprises: seriously vomit and suffer from diarrhoea, normal related have abdominal cramp and angor, fever, perspiration.Divide acute gastroenteritis and the large class of chronic enterogastritis two.Sick sending out seen General Symptoms: be chronic consumption symptom, and lustreless complexion lassitude, deficiency of QI with disinclination to talk, limbs fatigue, happiness temperature is afraid of cold, as at acute inflammation stage, except heating, visible dehydration, acidosis or the hemorrhage performance of suffering a shock; Symptom of digestive tract: often presenting discontinuity abdominal part dull pain, abdominal distention, stomachache, diarrhoea is primary disease main manifestations, meet the thing cold, oil-feed is greasy or meet anxious state of mind or tired rear outstanding work, times of defecation increases, go several times day or tens of remaining time, anus tenesmus, defecate not well, when chronic enteritis acute attack, visible high heat, abdominal colic, nausea and vomiting, stool are urgently as water or the sticky hemafecia that freezes; And sign aspect symptom: long-term abdominal discomfort or few abdominal part have a dull ache, the visible abdominal part of having a medical check-up, umbilicus week or few abdominal part are main, have mild tenderness, bowel sound hyperaction, proctoptosis.
Now, if only use western medicine, not only toxic and side effects is larger, and unsatisfactory curative effect.And adopt pure herbal treatment, not only healing period is short, and toxic and side effects is little and difficult recurrence.
Summary of the invention
Technical problem to be solved by this invention is, overcoming prior art provides a kind of effective reduction toxic and side effects, effectively treats short, the drug residue free and the drug regimen of the treatment equus gastroenteritis of toxic and side effects of convalescent period after equus gastroenteritis and treatment.
In order to solve the problems of the technologies described above, the invention provides a kind of drug regimen for the treatment of equus gastroenteritis, described Chinese medicine composition comprises following raw medicinal material: Fructus Crataegi (parched to brown), Massa Medicata Fermentata, Rhizoma Pinelliae Preparata, Poria, Pericarpium Citri Reticulatae, Semen Raphani and Pericarpium Arecae.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine composition is preferably, 20～30 parts of 20～30 parts of Fructus Crataegi (parched to brown)s, 15～25 parts of Massa Medicata Fermentata, 15～25 parts of Rhizoma Pinelliae Preparata, 15～25 parts, Poria, 7～15 parts of Pericarpium Citri Reticulataes, 7～15 parts of Semen Raphanis and Pericarpium Arecae.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine composition can also be, 24～26 parts of 24～26 parts of Fructus Crataegi (parched to brown)s, 19～21 parts of Massa Medicata Fermentata, 19～21 parts of Rhizoma Pinelliae Preparata, 19～21 parts, Poria, 9～11 parts of Pericarpium Citri Reticulataes, 9～11 parts of Semen Raphanis and Pericarpium Arecae.
The ratio of weight and number of the kind raw medicinal material in described Chinese medicine composition also can be preferably, 25 parts of 25 parts of Fructus Crataegi (parched to brown)s, 20 parts of Massa Medicata Fermentata, 20 parts of Rhizoma Pinelliae Preparata, 20 parts, Poria, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Semen Raphanis and Pericarpium Arecae.
Described Chinese medicine composition can further include the Radix Angelicae Dahuricae, and the ratio of weight and number of the described Radix Angelicae Dahuricae is 15～20 parts.Be preferably 18 parts.
Described Chinese medicine composition can further include Folium Perillae, Radix Glycyrrhizae, Cortex Magnoliae Officinalis and the Rhizoma Atractylodis Macrocephalae, and ratio of weight and number is respectively Folium Perillae 15-20 part, 15～20 parts, Radix Glycyrrhizae, Cortex Magnoliae Officinalis 8-15 part and Rhizoma Atractylodis Macrocephalae 10-15 part.Be preferably 12 parts of 16 parts of Folium Perillaes, 16 parts, Radix Glycyrrhizae, 10 parts of Cortex Magnoliae Officinalis and the Rhizoma Atractylodis Macrocephalaes.
The present invention also provides the preparation method of the drug regimen of above-mentioned any one treatment equus gastroenteritis, and the preparation method of described Chinese medicine composition is,
Step 1: take various raw medicinal materials according to percentage by weight, mix, be ground into powder, granularity is 20-200 order;
Step 2: to the yellow wine that adds 90 ~ 110 parts in the powder of step 1, mix homogeneously.
Wherein, the granularity in described step 1 is preferably 150-200 order.
The present invention provides again the preparation method of the drug regimen of above-mentioned any one treatment equus gastroenteritis, and the preparation method of described Chinese medicine composition comprises the following steps,
The first step, is mixed in proportion described component, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;
The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of powder quality that second step obtains;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 20～200 orders;
The 5th step, to the yellow wine that adds 90 ~ 110 parts in the powder of the 4th step, mix homogeneously.
Wherein, the granularity in described the 5th step is preferably 150-200 order.
Wherein, the unit of above-mentioned various raw medicinal materials " part " is preferably " g ", and the unit " part " of yellow wine is preferably " ml ".
Beneficial effect of the present invention: the present invention is take warming spleen and stomach for dispelling cold, benefiting qi and raising yang as the rule for the treatment of, reasonable recipe, preparation technology is simple, applied widely.The present invention adopts pure Chinese medicinal herbs to make, wide material sources, cost are low, cure rate is high, medicine noresidue, have no side effect, particularly after micronizing, destroy to greatest extent plant cell wall, solved the deficiency that traditional drugs powder crude fiber content is high, effective ingredient is difficult to stripping, be easier to horses and absorb.There is the effect of significant anti-inflammation and stopping pain and adjusting body function, effectively treat equus gastroenteritis, shorten the period of convalescence with western medicine phase specific energy, and do not recur.
The specific embodiment
The invention provides a kind of drug regimen for the treatment of equus gastroenteritis, described Chinese medicine composition comprises following raw medicinal material: Fructus Crataegi (parched to brown), Massa Medicata Fermentata, Rhizoma Pinelliae Preparata, Poria, Pericarpium Citri Reticulatae, Semen Raphani and Pericarpium Arecae.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine composition is preferably, 20～30 parts of 20～30 parts of Fructus Crataegi (parched to brown)s, 15～25 parts of Massa Medicata Fermentata, 15～25 parts of Rhizoma Pinelliae Preparata, 15～25 parts, Poria, 7～15 parts of Pericarpium Citri Reticulataes, 7～15 parts of Semen Raphanis and Pericarpium Arecae.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine composition can also be, 24～26 parts of 24～26 parts of Fructus Crataegi (parched to brown)s, 19～21 parts of Massa Medicata Fermentata, 19～21 parts of Rhizoma Pinelliae Preparata, 19～21 parts, Poria, 9～11 parts of Pericarpium Citri Reticulataes, 9～11 parts of Semen Raphanis and Pericarpium Arecae.
The ratio of weight and number of the kind raw medicinal material in described Chinese medicine composition also can be preferably, 25 parts of 25 parts of Fructus Crataegi (parched to brown)s, 20 parts of Massa Medicata Fermentata, 20 parts of Rhizoma Pinelliae Preparata, 20 parts, Poria, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Semen Raphanis and Pericarpium Arecae.
Described Chinese medicine composition can further include the Radix Angelicae Dahuricae, and the ratio of weight and number of the described Radix Angelicae Dahuricae is 15～20 parts.Be preferably 18 parts.
Described Chinese medicine composition can further include Folium Perillae, Radix Glycyrrhizae, Cortex Magnoliae Officinalis and the Rhizoma Atractylodis Macrocephalae, and ratio of weight and number is respectively Folium Perillae 15-20 part, 15～20 parts, Radix Glycyrrhizae, Cortex Magnoliae Officinalis 8-15 part and Rhizoma Atractylodis Macrocephalae 10-15 part.Be preferably 12 parts of 16 parts of Folium Perillaes, 16 parts, Radix Glycyrrhizae, 10 parts of Cortex Magnoliae Officinalis and the Rhizoma Atractylodis Macrocephalaes.
The present invention also provides the preparation method of the drug regimen of above-mentioned any one treatment equus gastroenteritis, and the preparation method of described Chinese medicine composition is,
Step 1: take various raw medicinal materials according to percentage by weight, mix, be ground into powder, granularity is 20-200 order;
Step 2: to the yellow wine that adds 90 ~ 110 parts in the powder of step 1, mix homogeneously.
Granularity in described step 1 is preferably 150-200 order.
The present invention provides again the preparation method of the drug regimen of above-mentioned any one treatment equus gastroenteritis, and the preparation method of described Chinese medicine composition comprises the following steps,
The first step, is mixed in proportion described component, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;
The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of powder quality that second step obtains;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 20～200 orders;
The 5th step, to the yellow wine that adds 90 ~ 110 parts in the powder of the 4th step, mix homogeneously.
Granularity in described the 5th step is preferably 150-200 order.
The pharmacology of described each component is as follows:
Fructus Crataegi (parched to brown): sour in the mouth, sweet, slightly warm in nature, returns spleen, stomach, Liver Channel, cures mainly promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.
Massa Medicata Fermentata: for after the medicines such as Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum add flour or wheat bran mixed, the herbal leaven forming through fermentation, sweet in the mouth is pungent, warm in nature, nontoxic, enter spleen, stomach warp, can invigorating the spleen and regulating the stomach, in helping digestion and adjusting, cure mainly retention of food and drink, feeling of stuffiness in chest abdominal distention, vomiting dysentery, postnatal blood stasis stomachache, children's's enlarged abdomen is hard long-pending.
Rhizoma Pinelliae Preparata: be the Preparation process product of the Rhizoma Pinelliae, be class spherical or be broken into irregular particle shape.Surface yellowish white, yellow or brown color.Matter is more crisp or firmly crisp, and section is yellow or faint yellow, and granule person matter is slightly firmly crisp.Feeble QI, lightly seasoned slightly sweet, the micro-numb feeling in the tongue that has, acrid in the mouth, warm in nature, returns spleen, stomach, lung meridian, can drying dampness to eliminate phlegm, cure mainly abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache.
Poria: come from Shennong's Herbal, be commonly called as Poria, Song Ling, Poria, for colonizing in the fungi plant on pinaster root, shape is as Rhizoma Dioscoreae esculentae, crust pitchy, the inside white or pink.Its protozoa is the dry sclerotia of On Polyporaceae Poria, and multiparasitization is in the root of Pinus massoniana Lamb or Pinus densiflora.Originate in the ground such as Yunnan, Anhui, Hubei, Henan, Sichuan.Ancients claim that Poria is " god medicine " at 4 o'clock, because its effect is very extensive, regardless of the four seasons, by it and various compatibility of drugs, no matter cold, temperature, wind, all diseases that wets can be brought into play its unique effects.Poria sweet in the mouth, light, property are flat, be used as medicine there is promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.
Pericarpium Citri Reticulatae: another name: Pericarpium Citri tangerinae, expensive old, Folium Styracis Suberifoliae, Fructus Citri tangerinae skin, wide Pericarpium Citri tangerinae, Pericarpium Citri tangerinae, Citrus chachiensis Hort. C. Suavissima Tanaka, Pericarpium citri reticuatae chachiensis, bitter in the mouth, pungent, warm in nature, return lung, spleen channel, can regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, cure mainly fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm Pericarpium Citri Reticulatae if the winter Citrus chachiensis Hort. skin dry in the sun form, its quality is better, its appearance presents dark brown, and skin flesh is thin, be placed on and feel on hand gently and easily to fracture very much, simultaneously also with fragrant, wherein, " Guangdong three essentials-essence, Pericarpium Citri Reticulatae old ginger Ramulus et Folium Bauhiniae Faberi " inner Pericarpium Citri Reticulatae, be exactly specially to refer to Xinhui tangerine peel, have " Radix Ginseng in thousand, century-old Pericarpium Citri Reticulatae " say.The value of Xinhui tangerine peel, has some idea of.
Semen Raphani: another name Semen Raphani, trailing plants white chessman, Semen Raphani, property is flat, and acrid in the mouth, sweet, returns lung, spleen, stomach warp, the de-swelling that helps digestion, lowering the adverse-rising QI to resolve phlegm.Cure mainly stagnation of QI due to dyspepsia, distension and fullness in the abdomen, belch, heavy after dysentery, cough with copious phlegm, dyspnea with rapid and short breath fullness in the chest, Semen Raphani seed similar round or ellipse, slightly flat, long 2 to 4 millimeters, wide 2 to 3 millimeters.Seed coat is thin, and surface red is brown, yellowish-brown or dark-grey brown, and amplifying Microscopic observation has fine and closely woven reticulate pattern, and seed one side has several longitudinal furrows, and there is black hilum one end.2 of cotyledons, milk yellow, plumpness, has vertical close pleat, feeble QI, taste is slightly pungent.
Pericarpium Arecae: acrid in the mouth; Slightly warm in nature.Return spleen; Stomach; Large intestine; Small intestine meridian, can therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, and line water detumescence, cures mainly retention of damp leading to blockage of QI, and breast abdominal distention is vexed, defecate not well, and edema, beriberi, dysuria, is the dry peel of babassu Semen Arecae.Have another name called Semen Arecae clothing.Practise and claim " PERICARPIUM ARECAE ", raw using.There is therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, effect of line water detumescence.Modern study, these product have excited gastrointestinal smooth muscle, short digestive tract power effect, and have the effects such as the fibrinolysis of promotion, are traditional Chinese medical science common medicine.
Yellow wine: be field of medicaments, particularly very important adjuvant or " extra conductant ingredient " in the field of Chinese medicines.Help blood circulation, enhance metabolism, there is blood-enriching face-nourishing, the effect of the cold relieving of invigorating blood circulation, dredge the meridian passage, effectively the cold resisting stimulation, preventing cold.
The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature; Return lung, stomach, large intestine channel; Fragrance rises loose, has expelling pathogenic wind from the body surface, and dispersing cold for relieving pain, dehumidifies sensible, and effect of detumescence and apocenosis, cures mainly anemofrigid cold, headache, supraorbital bone pain, toothache, eye itching lacrimation, nasal obstruction, nasal sinusitis, wet chronic diarrhea, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, pruritus scabies, the venom contained.
Folium Perillae: call red Soviet Union, red Soviet Union, purple Soviet Union, wrinkle Folium Perillae, acrid in the mouth, warm in nature, return lung, spleen channel, can relieving the exterior syndrome by diaphoresis, regulating the flow of QI to ease the stomach, solving toxin of fish and crab, cures mainly anemofrigid cold, headache, cough, distension and fullness of the chest and abdomen, fish Eriocheir sinensis is poisoning.
Radix Glycyrrhizae: a kind of tonification Chinese herbal medicine.Medicinal part is root and rhizome, and Medicinal Materials Characters root is cylindrical, long 25～l00cm, diameter 0.6～3.5cm.Crust degree of tightness differs, the brown or taupe brown of surface red.Rhizome is cylindrical, and there is bud trace on surface, and there is marrow at section middle part.Feeble QI, taste is sweet and special.Function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc.Happiness sunlight is abundant, the low dry climate of long temperature at sunshine.Radix Glycyrrhizae is grown in arid, semiarid desert steppe, desert edge and loess hill area more.
Cortex Magnoliae Officinalis: another name ZIPU, purple oil Piao, Wen Piao, oil Piao, pachydermia, pipe, magnolia hypoleuca, strong Piao, Cortex Magnoliae Officinalis, bitter in the mouth; Pungent; Warm in nature, return spleen channel; Stomach warp; Large intestine channel, can circulation of qi promoting removing food stagnancy; Dampness is except full; Lowering the adverse QI to relieve asthma, cures mainly stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant is stopped up QI rising in reverse order; Fullness in the chest is breathed with cough.
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, the cards such as frequent fetal movement; The effects such as the Rhizoma Atractylodis Macrocephalae has the gastrointestinal motility function of adjustment, antiulcer, protects the liver, enhancing human body immunity function, anti-stress, enhancing hemopoietic function; Its dampness diuretic effect is relevant with diuresis; And antiabortive effect is relevant with the effect of inhibition uterine contraction.The Rhizoma Atractylodis Macrocephalae also has the effects such as antioxidation, slow down aging, blood sugar lowering, anticoagulation, antitumor.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1:
Fructus Crataegi (parched to brown) 25g, Massa Medicata Fermentata 20g, Rhizoma Pinelliae Preparata 20g, Poria 20g, Pericarpium Citri Reticulatae 10g, Semen Raphani 10g and Pericarpium Arecae 25g.Mix, be ground into powder, granularity is 200 orders; In powder, add 100ml yellow wine, mix homogeneously.When use, gavage.
Embodiment 2:
Fructus Crataegi (parched to brown) 24g, Massa Medicata Fermentata 19g, Rhizoma Pinelliae Preparata 19g, Poria 20g, Pericarpium Citri Reticulatae 9g, Semen Raphani 9g, Pericarpium Arecae 24g and Radix Angelicae Dahuricae 18g.Mix, be ground into powder, granularity is 180 orders; In powder, add 90ml yellow wine, mix homogeneously.When use, gavage.
Embodiment 3:
Fructus Crataegi (parched to brown) 26g, Massa Medicata Fermentata 21g, Rhizoma Pinelliae Preparata 21g, Poria 19g, Pericarpium Citri Reticulatae 10g, Semen Raphani 11g, Pericarpium Arecae 26g, Folium Perillae 16g, Radix Glycyrrhizae 16g, Cortex Magnoliae Officinalis 10g and Rhizoma Atractylodis Macrocephalae 12g.Preparation method comprises the following steps:
The first step, is mixed in proportion various raw medicinal materials, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 10 hours, and with slow fire boiling, decocting time is 4 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 4 times of the powder quality that obtains of the first step;
The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 3 hours, filters and obtains the second filtrate, and the quality of the water adding is 3 times of powder quality that second step obtains;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 150 orders;
The 5th step, to the yellow wine that adds 100ml in the powder of the 4th step, mix homogeneously.
When use, gavage.
Embodiment 4:
Fructus Crataegi (parched to brown) 26g, Massa Medicata Fermentata 19g, Rhizoma Pinelliae Preparata 20g, Poria 21g, Pericarpium Citri Reticulatae 11g, Semen Raphani 10g, Pericarpium Arecae 25g, Radix Angelicae Dahuricae 20g, Folium Perillae 18g, Radix Glycyrrhizae 20g, Cortex Magnoliae Officinalis 12g and Rhizoma Atractylodis Macrocephalae 10g.Preparation method comprises the following steps:
The first step, is mixed in proportion various raw medicinal materials, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 8 hours, and with slow fire boiling, decocting time is 5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 3 times of the powder quality that obtains of the first step;
The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 4 hours, filters and obtains the second filtrate, and the quality of the water adding is 4 times of powder quality that second step obtains;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 200 orders;
The 5th step, to the yellow wine that adds 110ml in the powder of the 4th step, mix homogeneously.
When use, gavage.
Acute toxicity test:
120 of application NIH mices, SPF level, male and female half and half, body weight 18～22g, carries out acute toxicity testing.Mice is divided into three groups at random, be that (concentration is 6.28g crude drug/ml for the Chinese medicine composition of matched group, the administration embodiment of the present invention 1, maximum concentration) administration group 1 and the administration embodiment of the present invention 4 (concentration is 6.28g crude drug/ml, maximum concentration) the administration group 2 of Chinese medicine composition, fasting 12 hours before experiment.The Chinese medicinal powder that administration group 1 and administration group 2 are prepared embodiments of the invention 1 and embodiment 4 is respectively dissolved in water mouse stomach, gavage volume is 5ml/kg (being that single-dose dosage is 31.4g crude drug/kg), matched group gives equivalent normal saline, administration in 1 day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, mice overall health of patients, ingest, drinking-water, body weight gain is all normal.Therefore Chinese medicine acute toxicity of the present invention is low, clinical drug safety.
Clinical trial:
Chinese medicine composition avirulence of the present invention, easy to use, can directly gavage or add in feedstuff and use.When application, Chinese medicine composition of the present invention directly can be gavaged by per kilogram of body weight 0.4g crude drug, or mix in feedstuff and feed and suffer from poultry, and statistical data demonstration, generally can fully recover for the continuous 4-7 of taking days, and treatment time is short, clinical cure rate reaches 95%, and cure rate is high.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (10)
1. a drug regimen for the treatment of equus gastroenteritis, is characterized in that, described Chinese medicine composition comprises following raw medicinal material: Fructus Crataegi (parched to brown), Massa Medicata Fermentata, Rhizoma Pinelliae Preparata, Poria, Pericarpium Citri Reticulatae, Semen Raphani and Pericarpium Arecae.
2. the drug regimen for the treatment of equus gastroenteritis as claimed in claim 1, it is characterized in that: the ratio of weight and number of the various raw medicinal materials in described Chinese medicine composition is 20～30 parts of 20～30 parts of Fructus Crataegi (parched to brown)s, 15～25 parts of Massa Medicata Fermentata, 15～25 parts of Rhizoma Pinelliae Preparata, 15～25 parts, Poria, 7～15 parts of Pericarpium Citri Reticulataes, 7～15 parts of Semen Raphanis and Pericarpium Arecae.
3. the drug regimen for the treatment of equus gastroenteritis as claimed in claim 1 or 2, it is characterized in that: the ratio of weight and number of the various raw medicinal materials in described Chinese medicine composition is 24～26 parts of 24～26 parts of Fructus Crataegi (parched to brown)s, 19～21 parts of Massa Medicata Fermentata, 19～21 parts of Rhizoma Pinelliae Preparata, 19～21 parts, Poria, 9～11 parts of Pericarpium Citri Reticulataes, 9～11 parts of Semen Raphanis and Pericarpium Arecae.
4. the drug regimen of the treatment equus gastroenteritis as described in claims 1 to 3, it is characterized in that: the ratio of weight and number of the kind raw medicinal material in described Chinese medicine composition is 25 parts of 25 parts of Fructus Crataegi (parched to brown)s, 20 parts of Massa Medicata Fermentata, 20 parts of Rhizoma Pinelliae Preparata, 20 parts, Poria, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Semen Raphanis and Pericarpium Arecae.
5. the drug regimen of the treatment equus gastroenteritis as described in claim 1 to 4, is characterized in that: described Chinese medicine composition also further comprises the Radix Angelicae Dahuricae, the ratio of weight and number of the described Radix Angelicae Dahuricae is 15～20 parts.
6. the drug regimen of the treatment equus gastroenteritis as described in claim 1 to 5, it is characterized in that: described Chinese medicine composition also further comprises Folium Perillae, Radix Glycyrrhizae, Cortex Magnoliae Officinalis and the Rhizoma Atractylodis Macrocephalae, ratio of weight and number is respectively Folium Perillae 15-20 part, 15～20 parts, Radix Glycyrrhizae, Cortex Magnoliae Officinalis 8-15 part and Rhizoma Atractylodis Macrocephalae 10-15 part.
7. the drug regimen of the treatment equus gastroenteritis as described in claim 1 to 6, is characterized in that: the preparation method of described Chinese medicine composition is,
Step 1: take various raw medicinal materials according to percentage by weight, mix, be ground into powder, granularity is 20-200 order;
Step 2: to the yellow wine that adds 90 ~ 110 parts in the powder of step 1, mix homogeneously.
8. the drug regimen for the treatment of equus gastroenteritis as claimed in claim 7, is characterized in that: the granularity in described step 1 is 150-200 order.
9. the drug regimen of the treatment equus gastroenteritis as described in claim 1 to 6, is characterized in that:
The preparation method of described Chinese medicine composition comprises the following steps,
The first step, is mixed in proportion described component, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;
The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of powder quality that second step obtains;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 20～200 orders;
The 5th step, to the yellow wine that adds 90 ~ 110 parts in the powder of the 4th step, mix homogeneously.
10. the drug regimen for the treatment of equus gastroenteritis as claimed in claim 9, is characterized in that: the granularity in described the 5th step is 150-200 order.
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Application publication date: 20140514 |