CN105748887A - Traditional Chinese medicine composition for treating insomnia and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating insomnia and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating insomnia and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 34-51 parts of tuber fleeceflower stems, 13-22 parts of liquorice, 4-17 parts of lily, 10-24 parts of dragon bone, 4-11 parts of cortex albiziae, 3-20 parts of polygala tenuifolia, 5-13 parts of pericarpium citri reticulatae, 2-10 parts of ligusticum wallichii, 3-10 parts of angelica sinensis, 6-19 parts of poria cocos, 2-10 parts of arabian jasmine roots and 1-16 parts of rhizoma atractylodis macrocephalae. The preparation method comprises the following steps of: crushing and screening various components in parts by weight; adding water, heating the product at 60-90 DEG C for 60-80 minutes, filtering and cooling the product to obtain filtrate; concentrating the product until the relative density is 1.2-1.25; and carrying out ultraviolet disinfection. The prepared traditional Chinese medicine composition has the advantages of being high in safety, stable in curative effect and not easy to recur, and has significant economic and social benefits.
Description
Technical field
The present invention relates to technical field of Chinese medicine, particularly to a kind of Chinese medicine composition treating insomnia and preparation method thereof.
Background technology
Insomnia refers to that the length of one's sleep and (or) quality are unsatisfactory for and affect a kind of subjective experience of social function in the daytime by patient.
Insomnia can be divided into constitutional and Secondary cases two class by the cause of disease.Primary insomnia generally lacks the clear and definite cause of disease, or can getting rid of
Still leave over insomnia after causing the cause of disease of insomnia, mainly include Psychophysiological insomnia, idiopathic insomnia and subjective insomnia
3 types；Insomnia secondary includes the insomnia caused due to physical disease, mental disorder, drug dependence etc., and exhales with sleep
Inhale the insomnia that disorder, sleep movement obstacle etc. are relevant.Insomnia often occurs with other diseases simultaneously.
The Chinese patent of Application No. CN201310585058.2, discloses a kind of Chinese medicine composition anti-insomnia medicine, and its formula includes far
Will, Radix Bupleuri, cooked Semen Ziziphi Spinosae, Radix Salviae Miltiorrhizae, Cinnabaris, Semen Plantaginis, Radix Glycyrrhizae Preparata, Poria, Spica Prunellae and succinum, in described formula
Chinese medicine weight ratio is: Radix Polygalae 9%-18%, Radix Bupleuri 5%-12%, cooked Semen Ziziphi Spinosae 10%-28%, Radix Salviae Miltiorrhizae 10%-28%, Cinnabaris
1%-7%, Semen Plantaginis 1%-7%, Radix Glycyrrhizae Preparata 2%-10%, Poria 5%-12%, Spica Prunellae 2%-10%, succinum 1%-8
%.The compositions prepared easily recurs after taking, and therapeutic effect is poor simultaneously, it is impossible to meet Clinical practice requirement.
Summary of the invention
The invention provides a kind of Chinese medicine composition treating insomnia and preparation method thereof, the compositions safety prepared is high, curative effect
Stable, it is difficult to recurrence, has significant economic and social benefit.
In order to solve above-mentioned technical problem, the technical solution used in the present invention is: a kind of Chinese medicine composition treating insomnia, by with
Each component of lower mass parts is made: Caulis Polygoni Multiflori 34-51 part, Radix Glycyrrhizae 13-22 part, Bulbus Lilii 4-17 part, Os Draconis 10-24 part, conjunction
Joyous skin 4-11 part, Radix Polygalae 3-20 part, Pericarpium Citri Reticulatae 5-13 part, Rhizoma Chuanxiong 2-10 part, Radix Angelicae Sinensis 3-10 part, Poria 6-19 part, jasmine
Root 2-10 part, Rhizoma Atractylodis Macrocephalae 1-16 part.
Preferably, a kind of Chinese medicine composition treating insomnia, it is made up of each component of following mass parts: Caulis Polygoni Multiflori 39-45 part,
Radix Glycyrrhizae 18-21 part, Bulbus Lilii 6-12 part, Os Draconis 13-21 part, Cortex Albiziae 6-9 part, Radix Polygalae 5-15 part, Pericarpium Citri Reticulatae 6-10 part, river
Rhizome of chuanxiong 3-8 part, Radix Angelicae Sinensis 5-8 part, Poria 11-16 part, Radix Jasmini Sambac 6-9 part, Rhizoma Atractylodis Macrocephalae 4-10 part.
It is furthermore preferred that a kind of Chinese medicine composition treating insomnia, it is made up of each component of following mass parts: Caulis Polygoni Multiflori 41 parts, sweet
Grass 19 parts, Bulbus Lilii 8 parts, Os Draconis 16 parts, Cortex Albiziae 8 parts, Radix Polygalae 9 parts, Pericarpium Citri Reticulatae 9 parts, Rhizoma Chuanxiong 4 parts, Radix Angelicae Sinensis 6 parts,
12 parts of Poria, Radix Jasmini Sambac 8 parts, the Rhizoma Atractylodis Macrocephalae 5 parts.
The preparation method of a kind of Chinese medicine composition treating insomnia, comprises the following steps:
(1) by above-mentioned mass parts, by Caulis Polygoni Multiflori, Radix Glycyrrhizae, Bulbus Lilii, Os Draconis, Cortex Albiziae, Radix Polygalae, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, Radix Angelicae Sinensis,
Poria, Radix Jasmini Sambac, the Rhizoma Atractylodis Macrocephalae, pulverize, sieve, obtain compound；
(2) add water in step (1) gained compound, at 60-90 DEG C, heat 60-80min, after filtering cooling, obtain filtrate；
(3) step (2) gained filtrate being condensed into relative density is 1.2-1.25, i.e. obtains described treatment insomnia after ultraviolet-sterilization
Chinese medicine composition.
Preferably, in above-mentioned steps (2) 4-8 times that consumption is compound gross mass part of water.
Preferably, above-mentioned steps (2) heating process is carried out under the conditions of 0.3-0.7MPa.
Each components description of the composition present invention is as follows:
Caulis Polygoni Multiflori: cure mainly insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Bulbus Lilii: sweet in the mouth, cold in nature.There is nourishing YIN and moistening the lung, effect of clearing away heart-fire for tranquillization.It is usually used in deficiency of YIN cough caused by dryness, chronic cough hemoptysis, void
Irritability and frightering is throbbed with fear, insomnia and dreamful sleep, absentminded.
Os Draconis: tranquillization with heavy prescription tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, stop blooding astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Controlling infantile convulsion demented, palpitation with a distress feeling is forgetful,
Insomnia and dreamful sleep, spontaneous sweating, stranguria with turbid discharge of passing out semen, to tell nosebleed and have blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not closes up.
Cortex Albiziae: nature and flavor are sweet, flat.There are resolving depression and blood, mind calming, the merit of subduing inflammation.Control irritability, melancholy, insomnia,
Lung abscess, carbuncle, scrofula, injured bone it.
Radix Polygalae: there is Fructus Alpiniae Oxyphyllae of calming the nerves, the function eliminated the phlegm, subside a swelling, the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear,
Staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
Pericarpium Citri Reticulatae: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.
Rhizoma Chuanxiong: Xin Wenxiang is dry, walks and does not keeps, and can go scattered, up up to top, mountain peak；Enter again blood system, descending up to the sea of blood.Live
Blood and dissolving stasis effect is extensive, the various disease of suitable stagnation of blood stasis；Wind-expelling pain-stopping, effectiveness is favourable, can control wind syndrome of head headache, rheumatic arthralgia
Deng disease.
Radix Angelicae Sinensis: there is replenishing and activating blood, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation.It is usually used in blood deficiency and yellow complexion, dizziness cardiopalmus, menstruation
Uncomfortable, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.
Poria: promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, loose stool has loose bowels, the mind
Uneasiness, palpitation with fear insomnia.
Radix Jasmini Sambac: bitter, temperature.Poisonous.Anesthesia, pain relieving.For falling damage muscles and bones, dental caries, headache, insomnia.
The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema,
Spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
Beneficial effect: the Chinese medicine composition cure rate of the treatment insomnia that the present invention prepares is 91-97%, and total effective rate is
97%-100%, relapse rate is 0-1%, and safety is high, stable curative effect, is difficult to recurrence, has significant economic and social benefit.
Detailed description of the invention
Embodiment 1
A kind of Chinese medicine composition treating insomnia, is made up of each component of following mass parts: Caulis Polygoni Multiflori 34 parts, 13 parts of Radix Glycyrrhizae,
Bulbus Lilii 4 parts, Os Draconis 10 parts, Cortex Albiziae 4 parts, Radix Polygalae 3 parts, Pericarpium Citri Reticulatae 5 parts, Rhizoma Chuanxiong 2 parts, Radix Angelicae Sinensis 3 parts, 6 parts of Poria,
Radix Jasmini Sambac 2 parts, the Rhizoma Atractylodis Macrocephalae 1 part.
Preparation method:
(1) by above-mentioned mass parts, by Caulis Polygoni Multiflori, Radix Glycyrrhizae, Bulbus Lilii, Os Draconis, Cortex Albiziae, Radix Polygalae, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, Radix Angelicae Sinensis,
Poria, Radix Jasmini Sambac, the Rhizoma Atractylodis Macrocephalae, pulverize, sieve, obtain compound；
(2) add water in step (1) gained compound, at 60 DEG C, heat 60min, after filtering cooling, obtain filtrate, its
The consumption of middle water is 4 times of compound gross mass part, and heating process is carried out under the conditions of 0.3MPa；
(3) step (2) gained filtrate being condensed into relative density is 1.2-1.25, i.e. obtains described treatment insomnia after ultraviolet-sterilization
Chinese medicine composition.
Embodiment 2
A kind of Chinese medicine composition treating insomnia, is made up of each component of following mass parts: Caulis Polygoni Multiflori 51 parts, 22 parts of Radix Glycyrrhizae,
Bulbus Lilii 17 parts, Os Draconis 24 parts, Cortex Albiziae 11 parts, Radix Polygalae 20 parts, Pericarpium Citri Reticulatae 13 parts, Rhizoma Chuanxiong 10 parts, Radix Angelicae Sinensis 10 parts, Fu
Siberian cocklebur 19 parts, Radix Jasmini Sambac 10 parts, the Rhizoma Atractylodis Macrocephalae 16 parts.
Preparation method:
(1) by above-mentioned mass parts, by Caulis Polygoni Multiflori, Radix Glycyrrhizae, Bulbus Lilii, Os Draconis, Cortex Albiziae, Radix Polygalae, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, Radix Angelicae Sinensis,
Poria, Radix Jasmini Sambac, the Rhizoma Atractylodis Macrocephalae, pulverize, sieve, obtain compound；
(2) add water in step (1) gained compound, at 90 DEG C, heat 80min, after filtering cooling, obtain filtrate, its
The consumption of middle water is 8 times of compound gross mass part, and heating process is carried out under the conditions of 0.7MPa；
(3) step (2) gained filtrate being condensed into relative density is 1.2-1.25, i.e. obtains described treatment insomnia after ultraviolet-sterilization
Chinese medicine composition.
Embodiment 3
A kind of Chinese medicine composition treating insomnia, is made up of each component of following mass parts: Caulis Polygoni Multiflori 39 parts, 18 parts of Radix Glycyrrhizae,
Bulbus Lilii 6 parts, Os Draconis 13 parts, Cortex Albiziae 6 parts, Radix Polygalae 5 parts, Pericarpium Citri Reticulatae 6 parts, Rhizoma Chuanxiong 3 parts, Radix Angelicae Sinensis 5 parts, Poria 11
Part, Radix Jasmini Sambac 6 parts, the Rhizoma Atractylodis Macrocephalae 4 parts.
Preparation method:
(1) by above-mentioned mass parts, by Caulis Polygoni Multiflori, Radix Glycyrrhizae, Bulbus Lilii, Os Draconis, Cortex Albiziae, Radix Polygalae, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, Radix Angelicae Sinensis,
Poria, Radix Jasmini Sambac, the Rhizoma Atractylodis Macrocephalae, pulverize, sieve, obtain compound；
(2) add water in step (1) gained compound, at 70 DEG C, heat 65min, after filtering cooling, obtain filtrate, its
The consumption of middle water is 5 times of compound gross mass part, and heating process is carried out under the conditions of 0.4MPa；
(3) step (2) gained filtrate being condensed into relative density is 1.2-1.25, i.e. obtains described treatment insomnia after ultraviolet-sterilization
Chinese medicine composition.
Embodiment 4
A kind of Chinese medicine composition treating insomnia, is made up of each component of following mass parts: Caulis Polygoni Multiflori 45 parts, 21 parts of Radix Glycyrrhizae,
Bulbus Lilii 12 parts, Os Draconis 21 parts, Cortex Albiziae 9 parts, Radix Polygalae 15 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Chuanxiong 8 parts, Radix Angelicae Sinensis 8 parts, Poria
16 parts, Radix Jasmini Sambac 9 parts, the Rhizoma Atractylodis Macrocephalae 10 parts.
Preparation method:
(1) by above-mentioned mass parts, by Caulis Polygoni Multiflori, Radix Glycyrrhizae, Bulbus Lilii, Os Draconis, Cortex Albiziae, Radix Polygalae, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, Radix Angelicae Sinensis,
Poria, Radix Jasmini Sambac, the Rhizoma Atractylodis Macrocephalae, pulverize, sieve, obtain compound；
(2) add water in step (1) gained compound, at 80 DEG C, heat 75min, after filtering cooling, obtain filtrate, its
The consumption of middle water is 7 times of compound gross mass part, and heating process is carried out under the conditions of 0.6MPa；
(3) step (2) gained filtrate being condensed into relative density is 1.2-1.25, i.e. obtains described treatment insomnia after ultraviolet-sterilization
Chinese medicine composition.
Embodiment 5
A kind of Chinese medicine composition treating insomnia, is made up of each component of following mass parts: Caulis Polygoni Multiflori 41 parts, 19 parts of Radix Glycyrrhizae,
Bulbus Lilii 8 parts, Os Draconis 16 parts, Cortex Albiziae 8 parts, Radix Polygalae 9 parts, Pericarpium Citri Reticulatae 9 parts, Rhizoma Chuanxiong 4 parts, Radix Angelicae Sinensis 6 parts, Poria 12
Part, Radix Jasmini Sambac 8 parts, the Rhizoma Atractylodis Macrocephalae 5 parts.
Preparation method:
(1) by above-mentioned mass parts, by Caulis Polygoni Multiflori, Radix Glycyrrhizae, Bulbus Lilii, Os Draconis, Cortex Albiziae, Radix Polygalae, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, Radix Angelicae Sinensis,
Poria, Radix Jasmini Sambac, the Rhizoma Atractylodis Macrocephalae, pulverize, sieve, obtain compound；
(2) add water in step (1) gained compound, at 70 DEG C, heat 70min, after filtering cooling, obtain filtrate, its
The consumption of middle water is 6 times of compound gross mass part, and heating process is carried out under the conditions of 0.5MPa；
(3) step (2) gained filtrate being condensed into relative density is 1.2-1.25, i.e. obtains described treatment insomnia after ultraviolet-sterilization
Chinese medicine composition.
Comparative example
The Chinese patent of Application No. CN201310585058.2, discloses a kind of Chinese medicine composition anti-insomnia medicine, and its formula includes far
Will, Radix Bupleuri, cooked Semen Ziziphi Spinosae, Radix Salviae Miltiorrhizae, Cinnabaris, Semen Plantaginis, Radix Glycyrrhizae Preparata, Poria, Spica Prunellae and succinum, in described formula
Chinese medicine weight ratio is: Radix Polygalae 9%-18%, Radix Bupleuri 5%-12%, cooked Semen Ziziphi Spinosae 10%-28%, Radix Salviae Miltiorrhizae 10%-28%, Zhu
Sand 1%-7%, Semen Plantaginis 1%-7%, Radix Glycyrrhizae Preparata 2%-10%, Poria 5%-12%, Spica Prunellae 2%-10%, succinum 1
%-8%
Preparation method is, uses traditional method to decoct, by Chinese medicine polygala root, and Radix Bupleuri, cooked Semen Ziziphi Spinosae, Radix Salviae Miltiorrhizae, Cinnabaris, Semen Plantaginis,
Radix Glycyrrhizae Preparata, Poria, Spica Prunellae and succinum decocting three times, every 100g Chinese medicine 1500ml that every time fetches water decocts, and then will decoct three
Loading in glass drying oven after medicine liquid-phase mixing after secondary, bottleneck sternly seals standby.
Clinical effectiveness:
Clinic randomly chooses 600 insomniaies, is randomly divided into 6 groups, often organizes 100 people, takes embodiment 1-5 and contrast
The compositions that example prepares, 7 days courses for the treatment of, adds up curative effect after 2 courses for the treatment of, result see table:
Efficacy determination:
Cure: insomnia takes a turn for the better, fall asleep fast；
Effective: insomnia makes moderate progress, can comparatively fast fall asleep；
Invalid: insomnia does not has improvement, still it is difficult to fall asleep.
As can be seen from the above table, the compositions cure rate that embodiment 1-5 prepares is 91-97%, and total effective rate is 97%-100%,
Relapse rate is 0-1%；And the compositions cure rate that comparative example prepares is 88%, total effective rate is 94%, and relapse rate is 12%.
It follows that the compositions that the present invention prepares all uses Chinese medicine ingredients, safety is high, stable curative effect, is difficult to recurrence, has aobvious
The economic and social benefit write.
Claims (6)
1. the Chinese medicine composition treating insomnia, it is characterized in that, be made up of the component of following mass parts: Caulis Polygoni Multiflori 34-51 part, Radix Glycyrrhizae 13-22 part, Bulbus Lilii 4-17 part, Os Draconis 10-24 part, Cortex Albiziae 4-11 part, Radix Polygalae 3-20 part, Pericarpium Citri Reticulatae 5-13 part, Rhizoma Chuanxiong 2-10 part, Radix Angelicae Sinensis 3-10 part, Poria 6-19 part, Radix Jasmini Sambac 2-10 part, Rhizoma Atractylodis Macrocephalae 1-16 part.
The Chinese medicine composition for the treatment of insomnia the most according to claim 1, it is characterized in that, be made up of the component of following mass parts: Caulis Polygoni Multiflori 39-45 part, Radix Glycyrrhizae 18-21 part, Bulbus Lilii 6-12 part, Os Draconis 13-21 part, Cortex Albiziae 6-9 part, Radix Polygalae 5-15 part, Pericarpium Citri Reticulatae 6-10 part, Rhizoma Chuanxiong 3-8 part, Radix Angelicae Sinensis 5-8 part, Poria 11-16 part, Radix Jasmini Sambac 6-9 part, Rhizoma Atractylodis Macrocephalae 4-10 part.
The Chinese medicine composition for the treatment of insomnia the most according to claim 1, it is characterized in that, be made up of the component of following mass parts: Caulis Polygoni Multiflori 41 parts, 19 parts of Radix Glycyrrhizae, Bulbus Lilii 8 parts, Os Draconis 16 parts, Cortex Albiziae 8 parts, Radix Polygalae 9 parts, Pericarpium Citri Reticulatae 9 parts, Rhizoma Chuanxiong 4 parts, Radix Angelicae Sinensis 6 parts, 12 parts of Poria, Radix Jasmini Sambac 8 parts, the Rhizoma Atractylodis Macrocephalae 5 parts.
4. described in claims 1 to 3 any one, treat the preparation method of the Chinese medicine composition of insomnia, it is characterised in that: comprise the following steps:
(1) by above-mentioned mass parts, by Caulis Polygoni Multiflori, Radix Glycyrrhizae, Bulbus Lilii, Os Draconis, Cortex Albiziae, Radix Polygalae, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Poria, Radix Jasmini Sambac, the Rhizoma Atractylodis Macrocephalae, pulverize, sieve, obtain compound；
(2) add water in step (1) gained compound, at 60-90 DEG C, heat 60-80min, after filtering cooling, obtain filtrate；
(3) step (2) gained filtrate being condensed into relative density is 1.2-1.25, i.e. obtains the Chinese medicine composition of described treatment insomnia after ultraviolet-sterilization.
5. the preparation method of the Chinese medicine composition having a sleepless night according to the treatment described in claim 4, it is characterised in that: in described step (2), the consumption of water is 4-8 times of compound gross mass part.
6. the preparation method of the Chinese medicine composition having a sleepless night according to the treatment described in claim 4, it is characterised in that: described step (2) heating process is carried out under the conditions of 0.3-0.7MPa.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101396512A (en) * | 2008-10-15 | 2009-04-01 | 黄建国 | Traditional Chinese medicine formulation for treating insomnia |
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| CN107823416A (en) * | 2017-12-22 | 2018-03-23 | 苏州斯尔斯特新材料科技有限公司 | A kind of medicine for treating insomnia and preparation method thereof |
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