CN108126021A - It is a kind of to treat lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine and preparation method thereof - Google Patents
It is a kind of to treat lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine and preparation method thereof Download PDFInfo
- Publication number
- CN108126021A CN108126021A CN201711455374.2A CN201711455374A CN108126021A CN 108126021 A CN108126021 A CN 108126021A CN 201711455374 A CN201711455374 A CN 201711455374A CN 108126021 A CN108126021 A CN 108126021A
- Authority
- CN
- China
- Prior art keywords
- lift
- parts
- fallen
- chinese medicine
- deficiency type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Birds (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to mouthwash fields, and in particular to a kind of to treat lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine and preparation method thereof.The lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine is treated, includes the component of following parts by weight：10~40 parts of 10~100 parts of gun additioner, 10~100 parts of halite, 10~80 parts of psoralea corylifolia, 10~100 parts of gypsum and dried peppermint leaf.It after above-mentioned composition is extracted by the relevant technologies, is mixed with auxiliary material, can be made into mouthwash and be used for clinic.It is confirmed by clinic application with pharmacological evaluation, drug of the present invention is apparent to the lift-off therapeutic effect fallen of tooth pine, curative for effect, particularly has significant curative effect to the lift-off symptom that falls of tooth pine caused by kidney deficiency.
Description
Technical field
The invention belongs to mouthwash fields, and in particular to it is a kind of treat the renal deficiency type tooth lift-off Chinese medicine mouth wash fallen of pine and
Preparation method.
Background technology
Tooth mobility is a kind of disease extremely common in the elderly, is also gradually developed in recent years to rejuvenation direction.Tooth
Loose compact not only influences the masticatory function of human normal, also results in profound odontopathy, enterogastric diseases or even can induce
A variety of organ diseases.Tooth mobility seriously affects the physical and mental health and quality of the life of human body.
The traditional Chinese medical science thinks, Shen controls bone, tooth being the surplus of the bone, and kidney qi both declined, and essence is lost, tooth become homeless it is foster, by being that tooth must not pacify and shake.
Such as Southern Song Dynasty's Yang Shiying《Renzhai Zhi Zhi Fang, Effective Recipes from Renzhai House》In mention：" dentary, eventually, the institute of marrow is supported for the institute of bone, the real master's of kidney.Therefore renal failure then tooth
It slits, it is hard that essence contains then tooth." be thus renal failure then tooth and gap, the solid then tooth of essence is hard, and all teeth are not crisp hard or easily shake or dredge and slit, must kidney qi it
Deficiency is when based on special kidney tonifying gas.Bright Yu Tuan《Medicine main story》It proposes：" or meaning pain and tooth shakes or call bitterly and worm is invaded
Erosion, and there is slot to dredge open-minded diet inconvenience person, it is frequently.On the whole gingival atrophy and the person of shaking, nephrons void, control suitable enriching yin and nourishing kidney
To want.”
Application No. is 201410111751.0 patent of invention " a kind of Chinese medicine mouth wash and preparation method thereof the " (applyings date：
2014.03.24) describe a kind of Chinese medicine mouth wash.The product is by aloe, Radix Salviae Miltiorrhizae, motherwort, the root of Dahurain angelica, lemon oil, peppermint
Alcohol, perilla herb oil, caryophyllus oil, ethyl alcohol, distilled water are prepared.There is provisional elimination ozostomia, disinfection, sterilization,
But the symptom to be come off of tooth mobility caused by renal deficiency type can not be played a role.
Application No. is a kind of patent of invention " mouthwash for preventing the canker sore " (applyings date of 201310617519.X：
2013.11.29) describe a kind of Chinese medicine mouth wash.The product be by wild chrysanthemum, honeysuckle, radix scutellariae, Cortex Phellodendri, tealeaves, peppermint,
Folium artemisiae argyi, the stem of noble dendrobium, felwort, radix bupleuri, Fructus Aurantii, corydalis tuber, rhizoma cyperi, Radix Curcumae, honey, hawthorn, radish, balsam pear, lotus root, ginger, white flower
Grass is prepared.The product can effectively prevent the generation of canker sore, but tooth mobility caused by renal deficiency type is intended to take off
Falling symptom can not play a role.
Application No. is 201410313736.4 patent of invention " a kind of mouthwash for nursing oral cavity and preparation method thereof " (Shens
It please day：2014.07.03) describe a kind of mouthwash.The product is by the concentrated liquid of tradition Chinese medicine I, the concentrated liquid of tradition Chinese medicine II, jasmine tea juice, tea
Polyphenol, metronidazole, erythromycin, water are prepared.Its energy clearing away heat and alleviating pain, antibacterial anti-inflammatory, effectively prevent mouth disease, prevent dental caries
The generation of the symptoms such as tooth, odontoneuralgia, canker sore, but antibiotics raw material has been used in the product, it is used for a long time not beneficial
There is no effect in health, and to renal deficiency type gomphiasis.
Mainstream mouthwash Li Shidelin on the market, is by cineole, menthol, gaultherolin, thymol, water, second
Alcohol, sorbierite, poloxamer188, benzoic acid, zinc chloride, sodium benzoate, Sucralose, essence, saccharin sodium, blue pigment etc.
It is prepared.It is in component to use chemical agent more, it should not be used for a long time.And the product is mainly used for preventing and reducing tooth
Stain, gingivitis can not play a role the symptom to be come off of tooth mobility caused by renal deficiency type.
At present, mouthwash it is wide in variety concentrate on sterilization, fresh breath in terms of, and the gomphiasis problem caused by kidney deficiency, but
It nobody shows any interest in.
Invention content
To solve the problems mentioned above in the background art,
An object of the present invention be to provide it is a kind of treat the lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine, supplement is existing
It is used to treating or preventing the lift-off blank for falling Chinese medicine mouth wash of renal deficiency type tooth pine in technology, improves the safety of mouthwash,
Accomplish it is without any side effects to human body, it is apparent to the lift-off therapeutic effect fallen of tooth pine, it is curative for effect, particularly kidney deficiency is drawn
The lift-off symptom that falls of tooth pine risen has significant curative effect.
The two of the object of the invention are to provide a kind of preparation method for treating the lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine,
Chinese medicine preparation with scientific and technological means is combined, extracts active principle to greatest extent, improves herbal medicine efficacy, is made convenient for promoting
With.
To achieve the above object, the present invention provides following technical solution：
Scheme one：
It is a kind of to treat the lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine, including following components, gun additioner, halite, benefit
Bone fat, gypsum and dried peppermint leaf.
It is a kind of to treat the lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine, include the component of following parts by weight：Gun additioner 10
10~40 parts of~100 parts, 10~100 parts of halite, 10~80 parts of psoralea corylifolia, 10~100 parts of gypsum and dried peppermint leaf.
Preferably, a kind of component treated the lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine, include following parts by weight：Big gun
15~35 parts of 30~80 parts of monkshood, 30~80 parts of halite, 30~60 parts of psoralea corylifolia, 30~80 parts of gypsum and dried peppermint leaf.
Preferably, lift-off fall of tooth pine is fallen for renal deficiency type tooth pine is lift-off.
Scheme two：
A kind of preparation method for treating the lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine, includes the following steps：
(1) gun additioner being taken to crush, adds purified water, homogeneous after sterilizing, connects strain, ferments, and freeze-drying obtains fermentation product, crushes,
Sieving, obtains yeast powder, spare；
(2) dried peppermint leaf is taken to crush, adds purified water, use CO2Supercritical extract 1~3 time extracts volatile oil, spare；
(3) psoralea corylifolia, gypsum are taken, adds purified water, concentration, extraction obtain concentrate, and dry is dry cream, is crushed, and sieving obtains
Dried cream powder, it is spare；
(4) dried cream powder, volatile oil, yeast powder, halite and auxiliary materials and mixing are taken, mouthwash is made.
The gun additioner powder and the mass ratio of purified water are 1:5~20, homogenization pressure be 0.15~0.35Mpa, homogeneous
Time is 5~15min, and sterilising temp is 100~120 DEG C, and sterilization time is 30~55min, and access strain is Trametes cinnabarina (Jacg) Franeh, is sent out
Ferment temperature is 20~40 DEG C, and fermentation humidity is 45~75%, and fermentation time is 20~45d, and it is 60~200 mesh to cross grit number；It is thin
Lotus leaf CO2The flow of supercritical extract is 20~60L/h, 32~37 DEG C of temperature, 20~70MPa of pressure, 30~80min of time；
Gypsum, psoralea corylifolia concentration vacuum degree are -0.05Mpa~-0.10Mpa, and thickening temperature is 50~100 DEG C, and liquid is condensed into ratio
Weight is to 1.00~1.25.
Preferably, gun additioner powder and the mass ratio of purified water are 1:13, homogenization pressure 0.25Mpa, homogenizing time are
10min, sterilising temp are 110 DEG C, sterilization time 43min, and access strain is Trametes cinnabarina (Jacg) Franeh, and fermentation temperature is 30 DEG C, fermentation
Humidity is 60%, fermentation time 33d, and it is 130 mesh to cross grit number；Dried peppermint leaf CO2The flow of supercritical extract is 40L/h, warm
35 DEG C of degree, pressure 45MPa, time 55min；Gypsum, psoralea corylifolia concentration vacuum degree are -0.08Mpa, and thickening temperature is 75 DEG C, will
Liquid is condensed into proportion to 1.13.
Preferably, the auxiliary material includes microcrystalline cellulose, alcohol and purified water.
Preferably, the preparation method of the lift-off Chinese medicine mouth wash fallen for the treatment of renal deficiency type tooth pine, it is characterised in that：
Preparation type is mouthwash or granule.
Compared with prior art, the beneficial effects of the invention are as follows：
1. for the lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine, supplement is used to treat or prevent kidney in the prior art
The lift-off blank for falling Chinese medicine mouth wash of deficiency tooth pine improves the safety of mouthwash, accomplish it is without any side effects to human body,
It is apparent to the lift-off therapeutic effect fallen of tooth pine, it is curative for effect, particularly it is lift-off to tooth pine caused by kidney deficiency fall symptom have it is aobvious
Write curative effect.
2. by ingredients such as the alkaloids in gun additioner, by fermentation method, retentive activity active ingredient removes toxicant,
Gun additioner effective rate of utilization is improved, excites gingival cell self-repairing capability, it will not be secondary caused by treating to gum, body etc.
Damage, so as to repair gum, permanent tooth anticreep.
3. using pure plant raw material, all active ingredients of product of the present invention are controlled in the tolerable range of human body
It is interior, there is tight security evaluation.
4. Chinese medicine preparation is combined with scientific and technological means, to greatest extent effective component extracting, herbal medicine efficacy is improved, just
In promoting the use of.
5. we are using traditional Chinese medicine theory as guidance, carefully prescription forms.Gun additioner Xin Ganre in side is longer than benefit fire and helps
Sun, recuperating depleted yang are monarch.Psoralea corylifolia is worked hard temperature, warming kidney and enhancing yang, gas antidiarrheal of receiving, and strengthens the work(that gun additioner is tonified the kidney and support yang, and is minister.
The product of gun additioner, Psoralea warm, with gypsum sweet pungent Great Cold, clearing heat-fire, relieving restlessness is quenched the thirst；Peppermint is pungent cool, dispelling wind-heat, clearly
The work(of the head mitigate gun additioner, psoralea corylifolia warm property, more than two tastes be adjutant.Halite is salty-cold, enters the heart, kidney channel, cool blood, bright
Mesh, and with tying-in be to make.All medicines share, play altogether warm kidney receive gas, permanent tooth anticreep the benefits of.
6. clinical practice and pharmacological evaluation confirm, drug of the present invention is apparent to the lift-off therapeutic effect fallen of tooth pine, curative effect
Definitely, particularly there is significant curative effect to the lift-off symptom that falls of tooth pine caused by kidney deficiency.
What 7. product compared with the prior art of the invention had has the beneficial effect that table：
Specific embodiment
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..
It is a kind of to treat the lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine, including following components, gun additioner, halite, benefit
Bone fat, gypsum and dried peppermint leaf.
Wherein, the sub- root of drying that gun additioner is cohosh rhizome of Chinese monkshood Aconitum carmichaeliDebx. processes
Product；Acrid flavour, sweet, property heat；Enter the heart, spleen, kidney channel；Recuperating depleted yang, mends fire supporing yang；
Psoralea corylifolia is the dry mature fruit of legumes psoraleae Psoraleacorylifolia L.；Acrid flavour, hardship,
It is warm-natured；Enter kidney, the spleen channel；Warming kidney and enhancing yang, receives gas antidiarrheal；
Gypsum is Sulfates mineral anhydrite race gypsum；It is sweet in flavor, pungent, property Great Cold；Enter lung, stomach；Clearing heat-fire removes
It is tired to quench the thirst；
Dried peppermint leaf is the dried leaf of labiate peppermint MenthahaplocalyxBriq.；Acrid flavour, it is cool in nature；Enter lung,
Liver Channel；Dispelling wind-heat, refresh oneself, promoting eruption；
Halite is halogenation species halite race lake salt crystalline solid；Taste is salty, cold in nature；Enter the heart, kidney channel；Cool blood, improving eyesight.
Further, a kind of component treated the lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine, include following parts by weight：
10~40 parts of 10~100 parts of gun additioner, 10~100 parts of halite, 10~80 parts of psoralea corylifolia, 10~100 parts of gypsum and dried peppermint leaf.
Further, a kind of component treated the lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine, include following parts by weight：
15~35 parts of 30~80 parts of gun additioner, 30~80 parts of halite, 30~60 parts of psoralea corylifolia, 30~80 parts of gypsum and dried peppermint leaf.
A kind of preparation method for treating the lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine, includes the following steps：
(1) gun additioner being taken to crush, adds purified water, homogeneous after sterilizing, connects strain, ferments, and freeze-drying obtains fermentation product, crushes,
Sieving, obtains yeast powder, spare；
(2) dried peppermint leaf is taken to crush, adds purified water, use CO2Supercritical extract 1~3 time extracts volatile oil, spare；
(3) psoralea corylifolia, gypsum are taken, adds purified water, concentration, extraction obtain concentrate, and dry is dry cream, crushes, crosses 100 mesh
Sieve, get dry extract powder, spare；
(4) dried cream powder, volatile oil, yeast powder, halite and auxiliary materials and mixing are taken, mouthwash is made.
Further, gun additioner powder and the mass ratio of purified water are 1:5~20, homogenization pressure is 0.15~0.35Mpa,
Homogenizing time is 5~15min, and sterilising temp is 100~120 DEG C, and sterilization time is 30~55min, and access strain is bright red bolt
Bacterium, fermentation temperature are 20~40 DEG C, and fermentation humidity is 45~75%, and fermentation time is 20~45d, and it is 60~200 to cross grit number
Mesh；Dried peppermint leaf CO2The flow of supercritical extract be 20~60L/h, 32~37 DEG C of temperature, 20~70MPa of pressure, the time 30~
80min；Gypsum, psoralea corylifolia concentration vacuum degree are -0.05Mpa~-0.10Mpa, and thickening temperature is 50~100 DEG C, and liquid is dense
Proportion is shortened into 1.00~1.25.
Further, gun additioner powder and the mass ratio of purified water are 1:13, homogenization pressure 0.25Mpa, during homogeneous
Between for 10min, sterilising temp is 110 DEG C, sterilization time 43min, and access strain is Trametes cinnabarina (Jacg) Franeh, and fermentation temperature is 30 DEG C,
Humidity of fermenting is 60%, fermentation time 33d, and it is 130 mesh to cross grit number；Dried peppermint leaf CO2The flow of supercritical extract is 40L/
H, 35 DEG C of temperature, pressure 45MPa, time 55min；Gypsum, psoralea corylifolia concentrate vacuum degree as -0.08Mpa, thickening temperature 75
DEG C, liquid is condensed into proportion to 1.13.
Further, auxiliary material includes microcrystalline cellulose, alcohol and purified water.
Further, preparation type is mouthwash or granule.
Further, lift-off fall of above-mentioned tooth pine is fallen for renal deficiency type tooth pine is lift-off.
Embodiment 1：
It is a kind of to treat the lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine, include the component of following parts by weight, gun additioner 30
Part, 30 parts of halite, 20 parts of psoralea corylifolia, 30 parts of gypsum and 10 parts of dried peppermint leaf.
(1) gun additioner of the above-mentioned formula parts by weight is taken, is crushed, crosses 80 mesh sieve, adds the purified water of 20 times of amounts, is carried out equal
Matter, homogenization pressure 0.25Mpa, homogenizing time 5min sterilize after homogeneous, and sterilising temp is 120 DEG C, and sterilization time is
43min.After sterilizing, strain inoculation is carried out, access strain is Trametes cinnabarina (Jacg) Franeh, is put into incubator and ferments, and fermentation temperature is 20 DEG C,
Humidity of fermenting is 75%, fermentation time 33d.Mycelia uniformly, be plumply covered with homogenizing fluid after, -4 DEG C of freeze overnights, taking-up is put
Enter freeze dryer freeze-drying, crush, cross 80 mesh sieve, obtain yeast powder, it is spare；
(2) dried peppermint leaf of the above-mentioned formula parts by weight is taken, is crushed, adds the purified water of 5 times of amounts, dried peppermint leaf CO2It is overcritical
Extraction 3 times, wherein, setting flow is 60L/h, and 35 DEG C of temperature, pressure 20MPa extract 80min, obtain volatile oil every time, spare；
(3) psoralea corylifolia, the gypsum of the above-mentioned formula parts by weight are taken, add 7 times amount purified waters, refluxing extraction 3 times, every time
30min is filtered, and is concentrated in vacuo, and concentration vacuum degree is -0.08Mpa, and thickening temperature is 50 DEG C, and liquid is condensed into proportion extremely
1.25, concentrate is obtained, dry is dry cream, is crushed, and crosses 80 mesh sieve, get dry extract powder, spare；
(4) dried cream powder, volatile oil, yeast powder, halite and auxiliary materials and mixing are taken, mouthwash is made.
Further, auxiliary material includes microcrystalline cellulose, alcohol, purified water.
Further, preparation type is mouthwash, granule.
Further, lift-off fall of above-mentioned tooth pine is fallen for renal deficiency type tooth pine is lift-off.
Embodiment 2：
It is a kind of to treat the lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine, include the component of following parts by weight, gun additioner 50
Part, 50 parts of halite, 30 parts of psoralea corylifolia, 40 parts of gypsum and 20 parts of dried peppermint leaf.
(1) gun additioner of the above-mentioned formula parts by weight is taken, crushes, sieves with 100 mesh sieve, adds the purified water of 5 times of amounts, is carried out equal
Matter, homogenization pressure 0.35Mpa, homogenizing time 10min sterilize after homogeneous, and sterilising temp is 100 DEG C, sterilization time
For 55min.After sterilizing, strain inoculation is carried out, access strain is Trametes cinnabarina (Jacg) Franeh, is put into incubator and ferments, fermentation temperature 30
DEG C, fermentation humidity is 45%, fermentation time 45d.Mycelia uniformly, be plumply covered with homogenizing fluid after, -4 DEG C of freeze overnights, take out
Freeze dryer freeze-drying is put into, is crushed, is sieved with 100 mesh sieve, obtain yeast powder, it is spare；
(2) dried peppermint leaf of the above-mentioned formula parts by weight is taken, is crushed, adds the purified water of 5 times of amounts, dried peppermint leaf CO2It is overcritical
Extraction 3 times, wherein, setting flow is 20L/h, and 37 DEG C of temperature, pressure 70MPa extract 30min, obtain volatile oil every time, spare；
(3) psoralea corylifolia, the gypsum of the above-mentioned formula parts by weight are taken, add 8 times amount purified waters, refluxing extraction 3 times, every time
30min is filtered, and is concentrated in vacuo, and concentration vacuum degree is -0.1Mpa, and thickening temperature is 75 DEG C, and liquid is condensed into proportion to 1, is obtained
Concentrate, dry is dry cream, crushes, sieves with 100 mesh sieve, get dry extract powder, spare；
(4) dried cream powder, volatile oil, yeast powder, halite and auxiliary materials and mixing are taken, mouthwash is made.
Further, auxiliary material includes microcrystalline cellulose, alcohol and purified water.
Further, preparation type is mouthwash and granule.
Further, lift-off fall of above-mentioned tooth pine is fallen for renal deficiency type tooth pine is lift-off.
Embodiment 3：
It is a kind of to treat the lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine, include the component of following parts by weight, gun additioner 80
Part, 80 parts of halite, 50 parts of psoralea corylifolia, 80 parts of gypsum and 30 parts of dried peppermint leaf
(1) gun additioner of the above-mentioned formula parts by weight is taken, crushes, sieves with 100 mesh sieve, adds the purified water of 13 times of amounts, is carried out
Homogeneous, homogenization pressure 0.15Mpa, homogenizing time 15min sterilize after homogeneous, and sterilising temp is 110 DEG C, during sterilizing
Between be 30min.After sterilizing, strain inoculation is carried out, access strain is Trametes cinnabarina (Jacg) Franeh, is put into incubator and ferments, fermentation temperature is
40 DEG C, fermentation humidity is 60%, fermentation time 20d.Mycelia uniformly, be plumply covered with homogenizing fluid after, -4 DEG C of freeze overnights take
Go out to be put into freeze dryer freeze-drying, crush, cross 200 mesh sieve, obtain yeast powder, it is spare；
(2) dried peppermint leaf of the above-mentioned formula parts by weight is taken, is crushed, adds the purified water of 7 times of amounts, dried peppermint leaf CO2It is overcritical
Extraction 3 times, wherein, setting flow is 40L/h, and 32 DEG C of temperature, pressure 70MPa extract 55min, obtain volatile oil every time, spare；
(3) psoralea corylifolia, the gypsum of the above-mentioned formula parts by weight are taken, add 10 times amount purified waters, refluxing extraction 3 times, often
Secondary 40min is filtered, and is concentrated in vacuo, and concentration vacuum degree is -0.05Mpa, and thickening temperature is 100 DEG C, and liquid is condensed into proportion extremely
1.13, concentrate is obtained, dry is dry cream, is crushed, and crosses 130 mesh sieve, get dry extract powder, spare；
(4) dried cream powder, volatile oil, yeast powder, halite and auxiliary materials and mixing are taken, mouthwash is made.
Further, auxiliary material includes microcrystalline cellulose, alcohol and purified water.
Further, preparation type is mouthwash or granule.
Further, lift-off fall of above-mentioned tooth pine is fallen for renal deficiency type tooth pine is lift-off.
The lift-off Chinese medicine mouth wash fallen for the treatment of renal deficiency type tooth pine that 1~embodiment of the embodiment of the present invention 3 produces, after testing
Its reliability and safety comply fully with relative national standards requirement, clinical treatment for example under：
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace
And modification, the scope of the present invention is defined by the appended.
Claims (9)
1. a kind of treat the lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine, it is characterised in that：Including following components, gun additioner,
Halite, psoralea corylifolia, gypsum and dried peppermint leaf.
2. a kind of treat the lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine, it is characterised in that：Include the component of following parts by weight：
10~40 parts of 10~100 parts of gun additioner, 10~100 parts of halite, 10~80 parts of psoralea corylifolia, 10~100 parts of gypsum and dried peppermint leaf.
3. the lift-off Chinese medicine mouth wash fallen for the treatment of renal deficiency type tooth pine according to claim 2, it is characterised in that：Including with
The component of lower parts by weight：30~80 parts of gun additioner, 30~80 parts of halite, 30~60 parts of psoralea corylifolia, 30~80 parts of gypsum and thin
15~35 parts of lotus leaf.
4. the preparation method of the lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine is treated according to claim 2, it is characterised in that：Packet
Include following steps：
（1）Gun additioner is taken to crush, adds purified water, homogeneous after sterilizing, connects strain, ferments, and freeze-drying obtains fermentation product, crushes, sieving,
Yeast powder is obtained, it is spare；
（2）Dried peppermint leaf is taken to crush, adds purified water, uses CO2Supercritical extract 1~3 time extracts volatile oil, spare；
（3）Psoralea corylifolia, gypsum are taken, adds purified water, concentration, extraction obtain concentrate, and dry is dry cream, is crushed, and sieving gets dry extract
Powder, it is spare；
（4）Dried cream powder, volatile oil, yeast powder, halite and auxiliary materials and mixing are taken, mouthwash is made.
5. the preparation method of the lift-off Chinese medicine mouth wash fallen for the treatment of renal deficiency type tooth pine according to claim 4, feature
It is：Gun additioner powder and the mass ratio of purified water are 1:5~20, homogenization pressure be 0.15~0.35Mpa, homogenizing time 5
~15min, sterilising temp be 100~120 DEG C, sterilization time be 30~55min, access strain be Trametes cinnabarina (Jacg) Franeh, fermentation temperature
It it is 20~40 DEG C, fermentation humidity is 45~75%, and fermentation time is 20~45d, and it is 60~200 mesh to cross grit number；Dried peppermint leaf CO2
The flow of supercritical extract is 20~60 L/h, 32~37 DEG C of temperature, 20~70MPa of pressure, 30~80 min of time；Stone
Cream, psoralea corylifolia concentration vacuum degree are -0.05Mpa~-0.10Mpa, and thickening temperature is 50~100 DEG C, and liquid is condensed into proportion
To 1.00~1.25.
6. the preparation method of the lift-off Chinese medicine mouth wash fallen for the treatment of renal deficiency type tooth pine according to claim 4, feature
It is：Gun additioner powder and the mass ratio of purified water are 1:13, homogenization pressure 0.25Mpa, homogenizing time 10min, sterilizing
Temperature is 110 DEG C, sterilization time 43min, and access strain is Trametes cinnabarina (Jacg) Franeh, and fermentation temperature is 30 DEG C, and fermentation humidity is 60%,
Fermentation time is 33d, and it is 130 mesh to cross grit number；Dried peppermint leaf CO2The flow of supercritical extract is 40L/h, and 35 DEG C of temperature is pressed
Power 45MPa, 55 min of time；Gypsum, psoralea corylifolia concentration vacuum degree are -0.08Mpa, and thickening temperature is 75 DEG C, and liquid is concentrated
Into proportion to 1.13.
7. the preparation method of the lift-off Chinese medicine mouth wash fallen for the treatment of renal deficiency type tooth pine according to claim 4, feature
It is：Auxiliary material includes microcrystalline cellulose, alcohol and purified water.
8. the preparation method of the lift-off Chinese medicine mouth wash fallen for the treatment of renal deficiency type tooth pine according to claim 4, feature
It is：Preparation type is mouthwash or granule.
9. the lift-off Chinese medicine mouth wash fallen for the treatment of renal deficiency type tooth pine according to claim 1, it is characterised in that：Tooth pine
Lift-off fall lift-off falls for renal deficiency type tooth pine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711455374.2A CN108126021B (en) | 2017-12-28 | 2017-12-28 | Traditional Chinese medicine mouth wash for treating kidney deficiency type loose and floating tooth and falling off and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711455374.2A CN108126021B (en) | 2017-12-28 | 2017-12-28 | Traditional Chinese medicine mouth wash for treating kidney deficiency type loose and floating tooth and falling off and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108126021A true CN108126021A (en) | 2018-06-08 |
| CN108126021B CN108126021B (en) | 2021-05-11 |
Family
ID=62393160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711455374.2A Active CN108126021B (en) | 2017-12-28 | 2017-12-28 | Traditional Chinese medicine mouth wash for treating kidney deficiency type loose and floating tooth and falling off and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108126021B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115414425A (en) * | 2022-08-23 | 2022-12-02 | 苗广华 | Novel formula tooth brushing powder |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127488A (en) * | 2014-08-11 | 2014-11-05 | 天津太平洋制药有限公司 | Method for extracting effective components from fresh mint leaves |
| CN107095929A (en) * | 2017-04-15 | 2017-08-29 | 天津太阳谷科技有限公司 | A kind of Chinese herbal medicine formula for treating and preventing tooth mobility |
-
2017
- 2017-12-28 CN CN201711455374.2A patent/CN108126021B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127488A (en) * | 2014-08-11 | 2014-11-05 | 天津太平洋制药有限公司 | Method for extracting effective components from fresh mint leaves |
| CN107095929A (en) * | 2017-04-15 | 2017-08-29 | 天津太阳谷科技有限公司 | A kind of Chinese herbal medicine formula for treating and preventing tooth mobility |
Non-Patent Citations (2)
| Title |
|---|
| 王身艳: "药用真菌发酵有毒中药草乌减毒增效基础研究", 《中国博士学位论文全文数据库》 * |
| 蔡姮婧: "治牙齿松动验方", 《开卷有益（求医问药）》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115414425A (en) * | 2022-08-23 | 2022-12-02 | 苗广华 | Novel formula tooth brushing powder |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108126021B (en) | 2021-05-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104127363A (en) | Anti-inflammation, swelling removing and sterilization toothpaste for adult | |
| CN102139030A (en) | Oral Chinese herbal preparation for treating gingivitis and preparation method thereof | |
| CN102145077B (en) | Oral Chinese medical preparation for treating acute periodontitis | |
| CN1294852C (en) | Drink with function of reducing pathogenic fire and nourishing body's essential fluid | |
| CN104888007A (en) | Ferment mouthrinse for treating dental ulcer and preparation method thereof | |
| CN111671882A (en) | Preparation for enhancing immunity and preparation device and method thereof | |
| CN104873446A (en) | Cinnamon oil containing toothpaste | |
| CN110652544A (en) | Pharmaceutical composition for treating rhinitis and preparation method thereof | |
| CN108126021A (en) | It is a kind of to treat lift-off Chinese medicine mouth wash fallen of renal deficiency type tooth pine and preparation method thereof | |
| CN107970286B (en) | Traditional Chinese medicine spray for treating kidney deficiency type loose and floating tooth and falling off and preparation method thereof | |
| CN104491359B (en) | It is a kind of to treat canker sore, Chinese medicine composition that pharyngitis swells and ache and preparation method thereof | |
| CN108030812B (en) | Traditional Chinese medicine dentifrice for treating kidney deficiency type loose and loose teeth and preparation method thereof | |
| CN108030732B (en) | Traditional Chinese medicine toothpaste for treating kidney deficiency type loose and floating tooth and preparation method thereof | |
| CN113521142A (en) | Pharmaceutical composition for treating seborrheic dermatitis, preparation method and application thereof, and head bath soaking agent and preparation method thereof | |
| CN1167455C (en) | Medicine for treating acne and its preparing process | |
| CN102552560B (en) | Compound combination medicament for effectively treating hand-foot-and-mouth disease | |
| CN105031170A (en) | Healthcare foot bath powder and preparing method thereof | |
| CN104922449A (en) | Traditional Chinese medicine disinfection solution and preparation method thereof | |
| CN108079076B (en) | Traditional Chinese medicine chewing gum for treating kidney deficiency type loose and loose teeth and preparation method thereof | |
| CN104523959B (en) | A kind of health care massage zaocys dhumnades olein | |
| CN108403910A (en) | A kind of tea medicine for treating eczema | |
| CN1098299A (en) | The sweet cool Kouchuang powder for curing aphthosis and the compound method thereof that are used for recurrent aphtha and all kinds of aphthas | |
| CN107854592A (en) | A kind of preparation method for the film for treating oral ulcer that can quickly eliminate pain | |
| CN104906352A (en) | Traditional Chinese medicine liquid for treating deficiency-fire flaring-up type infantile oral ulcer and preparation method thereof | |
| CN105833074A (en) | Traditional Chinese medicine composition for treating oral ulcer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |