CN102895471B - Medicine for treatment of acne, folliculitis and pustular herpes and preparation method thereof - Google Patents
Medicine for treatment of acne, folliculitis and pustular herpes and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a medicinal preparation for treatment of acne (pimples), folliculitis and pustular herpes and a preparation method thereof, and the medicine belongs to a Chinese medicinal tincture for treatment of inflammatory diseases of facial skin. The medicine provided in the invention is prepared from 87g-28g of paris polyphylla, 16g-6g of safflower, 12g-7g of Salvia Miltiorrhiza, 16g-8g of honeysuckle, 17g-6g of sophora flavescens, 12g-4g of Chinese honeylocust spines and 1000ml of 50%-80%V/V alcohol by means of a combined process of alcohol extraction and high-temperature cooking water extraction. The medicine can comprehensively adjust the metabolism of skin cells on facial skin, has strong effects of bacterium resisting, inflammation diminishing, blood circulation promoting and scar removing. With significant effects, the medicine generally takes effect in 3 days, and has the advantages of no toxic or side effect after long-term use, wide medicine sources, simple preparation, and easy promotion.
Description
Technical field
The present invention relates to pharmaceutical preparation of a kind of Acne treatment (comedo), folliculitis, pustular eruption and preparation method thereof, belong to the treatment Traditional Chinese medicine tincture preparation of the diseases associated with inflammation of facial area skin.
Background technology
Acne is also comedo or skin sore, is that adolescence endocrine changes, and androgen Secretion is to increasing, and smegma is vigorous, causes that skin follicle blocks, and adds that extraneous antibacterial makes nutriment amount reproduction with sebum in hair follicle and the inflammatory reaction that causes.Be commonly called as " acne ", " comedo ".Acne is very common, it is generally acknowledged relevant with endocrine, sebum and microorganism.Be more common in adolescence, man is more than female, and the course of disease is slow, after 40 years old, can alleviate or spontaneous recovery.The traditional Chinese medical science is referred to as " rosacea caused by lung-wind ".As radical cure not in time, the cicatrix that can cause the small pox of whole face redness, purple black impression and lifelong refractory to be healed.Too much because of smegma, a large amount of horny layer comes off (dead bark), after mixing, can make pore stop up with oils and fats dust and dirt, causes hair follicle inflamed.
The pathogenic factor of comedo: 1, endocrine disturbance: endocrine disturbance impels sebum secretion to cross Sheng, cannot discharge and by hair follicle block, for prerequisite has been built in the generation of comedo.The sebaceous gland of skin has the acceptor of a male hormone, and some people's acceptor is very sensitive, so if hormonal secretion slightly changes, all can have influence on the secretion of sebum.Some women, can realize before and after the menstrual cycle, or just sprouts comedo when large with pressure staying up late.2. follicular keratosis is abnormal: the horny layer on normal hair follicle mouth top is thinner, easily comes off, thereby guarantees that follicular orifice is unblocked, and sebum flows out smoothly.Otherwise, horny layer thickening difficult drop-off, the sebum that has little time to flow out will be blocked in follicular orifice, forms acne.Superfluous sebum can block pore, and the environment of few oxygen greasiness is conducive to the breeding of antibacterial and causes inflammation, and particularly anxiety or before menstrual period, there will be transience comedo.3. nervous system: too nervous or worried, can stimulate the generation of kidney parathyrine.Kidney parathyrine itself can carry out the normal growth of male hormone element, and then stimulates the secretion of oils and fats.4. sex hormone: some women, in adult age, there will be oily skin, major part is because their sebaceous gland easily absorbs male hormone, and stimulates the secretion of sebum.5. food: stuff oneself, lodge in body without abundant gastral food, dyspepsia, waste toxins drainage difficulty, and the hobby to high sugar beverage, fried class, seafood, all can bury the seed of trouble for the generation of comedo.6. weather: the secretion meeting of subcutaneous fat increases naturally along with the rising of external temperature, but changes oiliness skin in summer so be blended skin winter.7. unsuitable skin care products: the comparatively skin care products of oiliness, is only applicable to the maintenance of dryness skin.Otherwise, hair follicle can be blocked, make skin oil and fat secretion be difficult to excretion.
Though the external medicine preparation kind of Acne treatment, folliculitis, pustular eruption is more at present, has many drawbacks, as weak curative effect, relapse rate is high; Ingredients is main mainly with Western medicine, and shortcoming is that zest is strong, and side effect is larger, and improper use meeting increases the weight of the state of an illness.
The curative effect that the outer thing of applying medicinal lotion or ointment of existing a few Chinese drug preparation is dispelled pockmark is in addition also desirable not enough.As the technology of Chinese Patent Application No. 200910100553.3, its composition is Fructus Forsythiae, Flos Lonicerae, Radix Scutellariae, Radix Sophorae Flavescentis, Spina Gleditsiae, Radix Isatidis, Rhizoma Paridis, Folium Eriobotryae, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Cortex Phellodendri, Rhizoma Coptidis, Flos Chrysanthemi Indici, Fructus Mume, Herba Menthae, Oryza glutinosa, bran coat, composition is more complicated, the DeGrain of Synergistic treatment between medicine, although there is certain effect, but the trace effect that disappears of invigorating blood circulation is obviously inadequate, be unfavorable for that the short period cures; The and for example technology of Chinese Patent Application No. 200410012451.3, its composition is Flos Lonicerae, Flos Chrysanthemi Indici, Herba Taraxaci, Herba Violae, Fructus Forsythiae, Myrrha, Radix Polygoni Multiflori, Rhizoma Paridis, Radix Glycyrrhizae, Bombyx Batryticatus, it is a kind of oral medicine, to absorb through gastrointestinal, antiinflammatory to skin, the trace function that disappears of sterilizing, invigorate blood circulation are all undesirable, and have certain ill effect after digestive tract absorbs; For another example conventional eliminating acne turmeric liniment on market, its composition is Rhizoma Curcumae Longae, Rhizoma Paridis, Herba Polygoni cymosi, Herba Chenopodii, Herba Solidaginis, Herb Gynostemmae Pentaphylli, Rhizoma Zingiberis corallini, polyoxyethylene sorbitan monoleate, its inefficiency is up to 42%, and anti-inflammation detumescence function is general, and the trace function that disappears of invigorating blood circulation is also poor.
Summary of the invention
The object of this invention is to provide medicine of a kind of Acne treatment, folliculitis, pustular eruption and preparation method thereof, it can regulate the metabolism of facial area Skin Cell comprehensively, has antiinflammatory, the trace effect that disappears of sterilizing, invigorate blood circulation is remarkable, and ingredient is simple, toxic and side effects is little, and curative effect is fast.
Realizing the technical scheme that above-mentioned purpose of the present invention takes is:
This medicine is externally-applied liniment, ethanol 1000ml, the Rhizoma Paridis 87g～28g, Flos Carthami 16g～6g, Radix Salviae Miltiorrhizae 12g～7g, Flos Lonicerae 16g～8g, Radix Sophorae Flavescentis 17g～6g, day fourth 12g～4g that contain following composition and consumption thereof: 50%～80%V/V.
This medicine is the mixture of alcohol-pickled liquid and alcohol-pickled rear medicinal residues water cooking liquid.
The preparation method of this Acne treatment, folliculitis, herpes medicine is as follows:
A: Rhizoma Paridis 87g～28g, day fourth 12g～4g, be ground into powder with broken medicine machine standby;
B: get Rhizoma Paridis, day fourth powder pulverized and put into glass container together with Flos Carthami 16g～6g, Radix Salviae Miltiorrhizae 12g～7g, Flos Lonicerae 16g～8g, Radix Sophorae Flavescentis 17g～6g, add the ethanol 1000ml of 50～80%V/V, maintain the temperature between 18～26 ℃, soak >=15 days;
C: the medicinal residues that are immersed in ethanol are leached, and ethanol filtrate is stand-by;
D: medicinal residues decoct medicinal herbs vessel, add water logging to cross medicinal residues, after being heated to seethe with excitement, continue heating 20～35 minutes, in heating, medicinal residues are stirred in 2～3 minutes in interval, and medicine is fully mixed, and the medicinal liquid of cooling heating, leaches medicinal residues, stays cooling medicinal liquid stand-by;
E: the medicinal liquid that step C and step D are obtained mixes, removes container bottom precipitation after standing 24 hours, gained filling liquid obtains product.
This process for preparing medicine, also comprises following concrete technical scheme: 1. the grinding particle size of Rhizoma Paridis and day fourth is that fineness is 50～300 orders; 2. ethanol should be in sealed glass container soak medicine, and rock glass container every day once, allow and leach composition and be scattered in ethanol; 3. the water consumption of decocting in water medicinal residues is 1800～2000 ml, and while boiling to end, amount of liquid medicine is 900～1000ml.
Raw material source in this pharmaceutical preparation is in natural plants, and Rhizoma Paridis, Flos Carthami, day fourth, Radix Salviae Miltiorrhizae, Radix Sophorae Flavescentis, Flos Lonicerae, without hormone, have no side effect.Medicament composing prescription principle is:
Rhizoma Paridis: heat-clearing and toxic substances removing, subduing swelling and relieving pain;
Flos Carthami: promoting blood circulation to restore menstrual flow, scattered silt pain relieving;
It fourth: detumescence poison holding, evacuation of pus, parasite killing;
Radix Salviae Miltiorrhizae: blood circulation promoting and blood stasis dispelling, removing heat from blood detumescence;
Radix Sophorae Flavescentis: heat clearing and damp drying, killing parasites for relieving itching;
Flos Lonicerae: heat-clearing and toxic substances removing, dispelling wind dredging collateral.
All medicines coordinate, and respectively execute the chief, synergism, and curative effect is significantly improved.By pharmaceutical properties, pharmacological action after the preparation of simple extract drugs, there are a series of variations, its anti-inflammation, the disappear effect of trace of invigorating blood circulation is better.
The mechanism of medicine of the present invention is that the metabolism of facial area Skin Cell is regulated comprehensively, by powerful antiinflammatory, sterilize, invigorate blood circulation disappear trace function make facial area skin recover elasticity, can remove rapidly dirt, rubbish and the toxin of facial area skin, make facial area pore unblocked, accelerate facial area blood circulation, the cell of facial area aging is cleared out in time, impel the newborn cell of knitting to repair in time old and feeble downright bad histiocyte, thereby make the bright and clean exquisiteness of facial area, thereby reach good beauty therapeutic effect.Medicine of the present invention adopts liniment mode, and it directly acts on focus, does not enter blood circulation, and human body is had no side effect.Medicine includes many kinds of substance; main containing 10 several mineral materials such as several amino acids, sterone, flavonoid glycosides; be conducive to start with from the morbidity root of acne (comedo), folliculitis, pustular eruption; carry out antiinflammatory, the trace that disappears that sterilizes, invigorates blood circulation, have the effect of recovering human body facial area damaged cell normalization and medical treatment.
Beneficial effect of the present invention: the medicine with conventional therapy acne (comedo), folliculitis, pustular eruption is compared, the unique distinction that the present invention prepares medicine shows, 1, directly act on focus, without gastrointestinal and body cyclic metabolism, to Liver and kidney not damaged; 2, the former material of this medicine is all from the pure natural plant scape of occurring in nature, and integration of edible and medicinal herbs, without any damage, is fully natural green medicine to human body; 3, many medicine comprehensive improvements, multiple natural Chinese medicines material is worked in coordination with and has been brought into play better antiinflammatory, the trace function that disappears sterilizes, invigorates blood circulation, because compatibility rationally makes effect very remarkable, can remove dirt, rubbish and the toxin of facial area skin, make facial area pore unblocked, accelerate facial area blood circulation, the cell of facial area aging is cleared out in time, impel the newborn cell of knitting to repair in time old and feeble downright bad histiocyte, thereby make the bright and clean exquisiteness of facial area.
In process of clinical application, Viaminate common on medicine prepared by the present invention and market is tieed up E emulsifiable paste (production of traditional Chinese medicines Zhun Zi H50021843 Huabang Pharmaceutical Co., Ltd., Chongqing), eliminating acne turmeric liniment (production of traditional Chinese medicines Zhun Zi Z20025149 Guiyang Shumeida Pharmaceutical Factory Co., Ltd.) is all verified 64 routine cases, is compared as follows:
。
The specific embodiment
Embodiment 1: preparation method is as follows:
A: Rhizoma Paridis 87g, day fourth 4g, with broken medicine machine, being ground into fineness is that 60 object powder are standby;
B: get the leaf YIZHIHUA of pulverizing, day fourth powder is put into 4L glass container with cover together with Flos Carthami 16g, Radix Salviae Miltiorrhizae 12g, Flos Lonicerae 16g, Radix Sophorae Flavescentis 17g, add 80% ethanol 1000ml, build container cover, fully rock medicine in container, placing glass container, in cupboard, keeps the interior temperature of cupboard between 18～26 ℃.Rock glass container every day once, allow medicine fully soak 15 days in ethanol;
C: the medicinal residues that are immersed in ethanol are leached with clean silk to the alcohol-pickled solution for later use after filtration;
D: the medicinal residues after silk is filtered are put into clean Stainless steel basin, add about 2000L tap water, after being heated to seethe with excitement with big fire, continue to heat half an hour with moderate heat, in heating, to note medicinal residues of interval stirring in 2～3 minutes, medicine is fully mixed, and medicinal liquid boiling stops heating, the medicinal liquid of cooling heating after half an hour, medicinal residues in cooling medicinal liquid are leached with clean silk, leave the about 1000L of cooling medicinal liquid after high temperature steaming stand-by;
E: the medicinal liquid that step C and step D are obtained mixes, is statically placed in and in clean glass container, after 24 hours, dispels container bottom precipitation gained filling liquid and get final product.
Embodiment 2: preparation method is as follows:
A: Rhizoma Paridis 56g, day fourth 8g, with broken medicine machine, being ground into fineness is that 200 object powder are standby;
B: get the leaf YIZHIHUA of pulverizing, day fourth powder is put into 4L glass container with cover together with Flos Carthami 10g, Radix Salviae Miltiorrhizae 9g, Flos Lonicerae 12g, Radix Sophorae Flavescentis 11g, add 70% ethanol 1000ml, build container cover, fully rock medicine in container, placing glass container, in cupboard, keeps the interior temperature of cupboard between 18～26 ℃.Rock glass container every day once, allow medicine fully soak 17 days in ethanol;
C: the medicinal residues that are immersed in ethanol are leached with clean silk to the alcohol-pickled solution for later use after filtration;
D: the medicinal residues after silk is filtered are put into clean Stainless steel basin, add about 1800ml tap water, after being heated to seethe with excitement with big fire, continue with moderate heat heating 25 minutes, in heating, to note medicinal residues of interval stirring in 2～3 minutes, medicine is fully mixed, and medicinal liquid boiling stops heating, the medicinal liquid of cooling heating after half an hour, medicinal residues in cooling medicinal liquid are leached with clean silk, leave the about 950L of cooling medicinal liquid after high temperature steaming stand-by;
E: the medicinal liquid that step C and step D are obtained mixes, is statically placed in and in clean glass container, after 24 hours, dispels container bottom precipitation gained filling liquid and get final product.
Embodiment 3: preparation method is as follows:
A: Rhizoma Paridis 29g, day fourth 12g, with broken medicine machine, being ground into fineness is that 300 object powder are standby;
B: get the leaf YIZHIHUA of pulverizing, day fourth powder is put into 4L glass container with cover together with Flos Carthami 6g, Radix Salviae Miltiorrhizae 7g, Flos Lonicerae 8g, Radix Sophorae Flavescentis 6g, add 70% ethanol 1000ml, build container cover, fully rock medicine in container, placing glass container, in cupboard, keeps the interior temperature of cupboard between 18～26 ℃.Rock glass container every day once, allow medicine fully soak 15 days in ethanol;
C: the medicinal residues that are immersed in ethanol are leached with clean silk to the alcohol-pickled solution for later use after filtration;
D: the medicinal residues after silk is filtered are put into clean Stainless steel basin, add about 1900ml tap water, after being heated to seethe with excitement with big fire, continue with moderate heat heating 35 minutes, in heating, to note medicinal residues of interval stirring in 2～3 minutes, medicine is fully mixed, and medicinal liquid boiling stops heating, the medicinal liquid of cooling heating after half an hour, medicinal residues in cooling medicinal liquid are leached with clean silk, leave the about 950L of cooling medicinal liquid after high temperature steaming stand-by;
E: the medicinal liquid that step C and step D are obtained mixes, is statically placed in and in clean glass container, after 24 hours, dispels container bottom precipitation gained filling liquid and get final product.
Claims (4)
1. a medicine for Acne treatment, folliculitis, pustular eruption, is characterized in that into medicine composition and is:
Ethanol 1000ml, the Rhizoma Paridis 87g～28g of 50%～80%V/V, Flos Carthami 16g～6g, Radix Salviae Miltiorrhizae 12g～7g, Flos Lonicerae 16g～8g, Radix Sophorae Flavescentis 17g～6g, day fourth 12g～4g.
2. by the medicine of Acne treatment claimed in claim 1, folliculitis, pustular eruption, it is characterized in that: medicine is the mixture of alcohol-pickled liquid and alcohol-pickled rear medicinal residues water cooking liquid.
3. a preparation method for Acne treatment claimed in claim 1, folliculitis, pustular eruption medicine, is characterized in that step is as follows:
A: Rhizoma Paridis 87g～28g, day fourth 12g～4g, be ground into powder with broken medicine machine standby;
B: get Rhizoma Paridis, day fourth powder pulverized and put into glass container together with Flos Carthami 16g～6g, Radix Salviae Miltiorrhizae 12g～7g, Flos Lonicerae 16g～8g, Radix Sophorae Flavescentis 17g～6g, add the ethanol 1000ml of 50～80%V/V, maintain the temperature between 18～26 ℃, soak >=15 days;
C: the medicinal residues that are immersed in ethanol are leached, and ethanol filtrate is stand-by;
D: medicinal residues are put into decoct medicinal herbs vessel, adds water logging to cross medicinal residues, continues heating 20～35 minutes after being heated to seethe with excitement, and in heating, medicinal residues are stirred in 2～3 minutes in interval, and medicine is fully mixed, and the medicinal liquid of cooling heating, leaches medicinal residues, and cooling medicinal liquid is stand-by;
E: the medicinal liquid that step C and step D are obtained mixes, removes container bottom precipitation after standing 24 hours, gained filling liquid obtains product.
4. by the preparation method of Acne treatment claimed in claim 3, folliculitis, pustular eruption medicine, it is characterized in that: 1. the pulverizing grain fineness of Rhizoma Paridis and day fourth is 50～300 orders; 2. ethanol should be in sealed glass container soak medicine, and rock glass container every day once, allow and leach composition and be scattered in ethanol; 3. the water consumption of decocting in water medicinal residues is 1800～2000 ml, and while boiling to end, amount of liquid medicine is 900～1000ml.
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| CN101637578A (en) * | 2009-07-07 | 2010-02-03 | 朱建华 | Medicinal preparation for treating acnes, whelks and folliculitis and preparation method thereof |
| CN101979059A (en) * | 2010-10-26 | 2011-02-23 | 朱建华 | Medicinal preparation for treating acne and preparation method thereof |
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