CN103251713A - Traditional Chinese medicine preparation for treating livestock psoriasis - Google Patents

Abstract

The invention aims to provide a traditional Chinese medicine preparation for treating livestock psoriasis remarkable in treatment effect, free from toxic and side effects, free from tolerance and economic, effective and convenient. The preparation comprises the following raw materials in parts by weight: 1-10 parts of eriocarpous glochidion leaf, 1-10 parts of field bindweed, 1-10 parts of ice grass, 1-10 parts of cortex dictamni, 1-10 parts of radix angelicae, 1-10 parts of Lonicera confusa DC, 1-20 parts of cocklebur fruit, 10-20 parts of bark of himalayan coralbean, 10-20 parts of common andrographis Herb, 10-20 parts of wartwort, 10-20 parts of centella asiatica, 10-20 parts of Polygonum aviculare, 20-30 parts of lotus root starch, 20-30 parts of mulberry, 20-30 parts of Polygonum multiflorum, 20-30 parts of Semen sesami nigrum, 20-30 parts of bee pollen, 20-30 parts of cactus, 30-40 parts of tribulusterrestris, 30-40 parts of golden-rod, 30-40 parts of Ferula asafetida, 30-40 parts of calomel, 30-40 parts of lithargite and 30-40 parts of Mosla dianthera.

Description

A kind of Chinese medicine preparation for the poultry tinea

Technical field

The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine preparation for the poultry tinea.

Background technology

The poultry tinea, it is depressed spirit to occur, inappetence, pruritus, depilation, in around eyes, ear, abdominal part occurs earlier bearing 2～3 millimeters little yellow fluid bubbles of size behind the flushing, changes the whole skin redness after several days into, and very strong hotness is arranged, fervescence to 40 ℃～41 ℃, by a kind of infectious disease due to the infection of staphylococcus aureus, mainly because of low temperature, overcast and rainy moist, add that the delivery room sterilization is not thorough, environmental health is poor at ordinary times, the feeding and management misoperation infects acaricide, newborn animal fowl skin is sustained damage, indivedual disease resistance of livestock and poultry a little less than, the skin barrier function is damaged easily, causes staphylococcus to invade organism infection.Be noted that the time there are various mistaken ideas in the primary disease treatment, easily delay treating time and cause the poultry dehydration dead.

In animal husbandry, for many years polyenoid class antifungal drugs such as China's extensive use ampicillin, amphotericin-B treatment poultry tinea disease, skin and trichophyta then can produce drug resistance mostly, its preparation mainly is injection, tablet, suspensoid, powder, but these preparations are in poultry tinea disease processes, it is big also to exist drug waste, and drug price is higher, practical problems such as administration difficulty, labor intensity height.Abroad, tinea medicine and China are basic identical.

So far, provide a kind of therapeutic effect significantly, have no side effect, have no drug resistance, economical and effective a kind of Chinese medicine preparation for the poultry tinea easily, compel as pressing as a fire singeing one's eyebrows.

Summary of the invention

The purpose of this invention is to provide a kind of therapeutic effect significantly, have no side effect, have no drug resistance, economical and effective a kind of Chinese medicine preparation for the poultry tinea easily.

A kind of Chinese medicine preparation for the poultry tinea is characterized in that, is made up of the raw material of following weight portion:

Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 1-10 part, Herba seu Flos Convolvuli arvensis 1-10 part, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 1-10 part, Cortex Dictamni 1-10 part, Radix Angelicae Dahuricae 1-10 part, Folium Lonicerae Confusae 1-10 part, Fructus Xanthii 10-20 part, Cortex erythrinae 10-20 part, Herba Andrographis 10-20 part, Herba Euphorbiae Helioscopiae 10-20 part, Gotu Kola 10-20 part Herba Polygoni Avicularis 10-20 part, Amylum Nelumbinis Rhizomatis 20-30 part, Fructus Mori 20-30 part, Radix Polygoni Multiflori 20-30 part, Semen Sesami Nigrum 20-30 part, bee pollen 20-30 part, Caulis Echinopsis Multiplicis 20-30 part, Fructus Atriplicis Sibiricae 30-40 part, Herba Solidaginis 30-40 part, Resina Ferulae 30-40 part, Calomelas 30-40 part, Lithargyrum 30-40 part, Mosla dianthera 30-40 part;

Preparation method:

By formula proportion with above composition extract routinely, separate, dry, pulverize, composite in proportion, can be made into tablet, capsule, oral formulations, spray, liniment after mix homogeneously, the drying.

A kind of Chinese medicine preparation for the poultry tinea is characterized in that, is made up of the raw material of following weight portion:

Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 2-8 part, Herba seu Flos Convolvuli arvensis 2-8 part, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 2-8 part, Cortex Dictamni 2-8 part, Radix Angelicae Dahuricae 2-8 part, Folium Lonicerae Confusae 2-8 part, Fructus Xanthii 12-18 part, Cortex erythrinae 12-18 part, Herba Andrographis 12-18 part, Herba Euphorbiae Helioscopiae 12-18 part, Gotu Kola 12-18 part Herba Polygoni Avicularis 12-18 part, Amylum Nelumbinis Rhizomatis 22-28 part, Fructus Mori 22-28 part, Radix Polygoni Multiflori 22-28 part, Semen Sesami Nigrum 22-28 part, bee pollen 22-28 part, Caulis Echinopsis Multiplicis 22-28 part, Fructus Atriplicis Sibiricae 32-38 part, Herba Solidaginis 32-38 part, Resina Ferulae 32-38 part, Calomelas 32-38 part, Lithargyrum 32-38 part, Mosla dianthera 32-38 part.

A kind of Chinese medicine preparation for the poultry tinea is characterized in that, is made up of the raw material of following weight portion:

5 parts of Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi)s, 5 parts of Herba seu Flos Convolvuli arvensves, 5 parts of Isodonpubescens (Hemsl.) C. Y. Wuet Hsuans, 5 parts of Cortex Dictamni, 5 parts of the Radixs Angelicae Dahuricae, 5 parts of Folium Lonicerae Confusae, 15 parts of Fructus Xanthii, 15 parts of Cortex erythrinaes, 15 parts of Herba Andrographis, 15 parts of Herba Euphorbiae Helioscopiae, Gotu Kola 15 15 parts of Fen, Herba Polygoni Avicularis, 25 parts of Amylum Nelumbinis Rhizomatis, 25 parts in Fructus Mori, 25 parts of Radix Polygoni Multiflori, 25 parts of Semen Sesami Nigrums, 25 parts of bee pollen, 25 parts of Caulis Echinopsis Multipliciss, 35 parts of Fructus Atriplicis Sibiricaees, 35 parts of Herba Solidaginiss, 35 parts of Resina Ferulaes, 35 parts of Calomelass, 35 parts of Lithargyrums, 35 parts of Mosla diantheras.

The present invention relates to pharmacology and the property of medicine of Chinese medicine:

Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi):

[meridian distribution of property and flavor] bitter but sweet flavor is puckery, and property is flat;

[effect] dispelling wind and dampness, dissipating blood stasis, hemostasis, detumescence.Cure mainly acute gastroenteritis, dysentery, rheumatic arthritis, traumatic injury, wound hemorrhage, dermatitis rhus, eczema, dermatitis; Control Toxicodendron verniciflnum (Stokes) F. A. Barkley (Rhus verniciflua Stokes) allergy, paddy field dermatitis, skin pruritus, exfoliative dermatitis, urticaria, eczema: the bright leaf of Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) or cured leaf, decoction being used as a lotion.

Herba seu Flos Convolvuli arvensis:

[nature and flavor] suffering; Temperature; Poisonous; Return kidney channel.　　

[function cures mainly] dispelling wind for relieving itching; Pain relieving.The main air pain of dampness syndrome; Toothache; Neurodermatitis.

Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan:

[meridian distribution of property and flavor] is hot, bitter, and be flat.

[effect cures mainly] dispelling wind dampness removing, the circulation of qi promoting dissipating blood stasis.Be used for headache due to common cold, gastroenteritis, dysentery, abdominal distention; Treating swelling and pain by traumatic injury is controlled in external, wound hemorrhage, carbuncle sore tumefacting virus, worm venom, eczema, dermatitis.

Cortex Dictamni:

[meridian distribution of property and flavor] bitter cold is gone into spleen, the stomach warp.

[function] heat-clearing and toxic substances removing, expelling wind and removing dampness.Be used for diseases such as damp and hot sore, rubella, scabies, skin scratch, arthralgia chiefly caused by damp pathogen, jaundice.

The Radix Angelicae Dahuricae:

[nature and flavor] suffering, temperature are gone into lung, spleen, stomach warp;

[effect] controls headache, supraorbital bone pain, toothache, cold-damp stomachache, skin pruritus, scabies.

Folium Lonicerae Confusae:

[meridian distribution of property and flavor] is sweet, cold, goes into lung, spleen two warps;

[curing mainly] heat-clearing and toxic substances removing; Control carbuncle skin ulcer, furunculosis, numb varioliform exanthema poison, chancre, dysentery, dermatosis, heat in blood.

Gotu Kola:

[nature and flavor] are bitter, hot, cold; Very toxic.

[function cures mainly] dispels the wind, detoxifcation, parasite killing.The external treating rheumatic arthritis, skin is itched, and kills maggot, wriggler, water-snail eradication, malicious Mus.

Fructus Atriplicis Sibiricae:

[meridian distribution of property and flavor] is bitter, hot; Go into Liver Channel.

[function] suppressing the hyperactive liver resolving depression, dispelling pathogenic wind for improving eyesight is used for the dizziness due to hyperactivity of liver-YANG headache, hypochondriac pain due to stagnation of liverQI, headache due to pathogenic wind-heat, conjunctival congestion and swelling pain, diseases such as skin pruritus.

Semen Sesami Nigrum:

[nature and flavor] are flat, sweet in the mouth.

[effect] invigorating the liver and kidney, benefiting essence-blood, intestine moistening is dry; Be used for dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.

Fructus Xanthii:

Acrid in the mouth, hardship, warm in nature, poisonous.Return lung meridian.

Function with diffusing wind dehumidifying, understand things pain-stopping.Living Fructus Xanthii is strong with wind-repellent itching-relieving power.Be usually used in itchy skin eruption and other dermatosiss.

Nasosinusitis headache, rheumatic arthralgia.And it is burnt to fry the crisp thorn of back matter, is easy to deburring and fried effective ingredient.

Fructus Xanthii: the wind dehumidifying of loosing, clearing the nasal passage.Be used for headche due to wind-cold, nasal sinusitis watery nasal discharge, rubella pruritus, arthralgia chiefly caused by damp pathogen contracture.

Herba Xanthii grass: metrorrhagia, deep abscess, leprosy, skin eczema.

The Herba Xanthii herb is hyoscine also, controls acute and chronic gastroenteritis, bacillary dysentery.

Amylum Nelumbinis Rhizomatis:

[nature and flavor] sweet in the mouth, property are put down.

[function cures mainly] cures mainly cough due to lung-heat, irritated thirsty, diarrhea due to hypofunction of the spleen, inappetence and various blood disorder.Give birth to ripe equal edible, it is thirsty to cure mainly heat, the congestion that looses, granulation promoting.

Cortex erythrinae: wind-damp dispelling, the meridian dredging, parasite killing.Cure mainly: dispelling the wind and dampness pathogens arthralgia pain, dysentery, toothache, scabies.

Herba Andrographis:

[meridian distribution of property and flavor] hardship, cold, GUIXIN, lung, large intestine, urinary bladder channel.

[function cures mainly] heat-clearing and toxic substances removing, removing heat from blood, detumescence.Be used for cold, fever, laryngopharynx swelling and pain, aphtha of the mouth and tongue, pertussis chronic cough, dysentery, the puckery pain of pyretic stranguria, carbuncle skin infection, venom, treatment neurodermatitis, eczema.

Herba Euphorbiae Helioscopiae:

[meridian distribution of property and flavor] is hot, bitter, is slightly cold; Poisonous.Return lung, small intestinal, large intestine channel.

[function cures mainly] inducing diuresis to remove edema, dissipating phlegm and resolving masses, parasite killing.Be used for edema, cirrhotic ascites, bacillary dysentery; Tuberculous lymphadenitis is controlled in external, tuberculosis fistula, neurodermatitis.And can go out maggot, wriggler.These species are the poisonous plants that include in Chinese Plants spectrum data storehouse, and its toxicity is that Herb is poisonous, and milk swashs effect to the oral mucosa spinosity, as goes into ophthalmic and lose bright danger.Excessive cause stomachache, diarrhoea, vomiting, severe patient dehydration for oral administration.

Herba Polygoni Avicularis:

Hardship is slightly cold.Return urinary bladder channel.This product hardship is fallen row, the tonneau bladder, bitter dry again can the parasite killing removing damp to relieve itching, be mainly used in drenching pain and eczema.

1. relieving stranguria by diuresis is used for damp-heat gonorrhoea, can treat urinary system infection, calculus, hematuria etc.

2. killing parasites for relieving itching can be treated parasitic disease such as pinworm.Also can fry in shallow oil soup washout treatment skin skin ulcer rash, pruritus.

3. control dysentery with red and white feces, jaundice.

Fructus Mori:

[nature and flavor] are sweet, are slightly cold; GUIXIN, liver, kidney channel.

[function cures mainly] treating the liver kidney yin is lost, and send and take off, constipation, order is dark, tinnitus, former infections, articular instability.It has the skin of improvement (comprising scalp) blood supply, the nutrition skin, makes effect such as the delicate and black hair of skin, and can slow down aging.Fructus Mori is be healthy and strong U.S. face, antidotal good fruit and good medicine of middle-aged and elderly people.Normal food Fructus Mori can make eye bright, the tired dry and astringent symptom of easing eyes.Fructus Mori has immunologic enhancement.Fructus Mori has effect of gain to spleen, and reaction has potentiation to hemolytic, can prevent human body artery sclerosis, skeleton arthrosclerosis, enhances metabolism; Fructus Mori can promote the growth of erythrocyte, prevents leukopenia, and diseases such as treatment diabetes, anemia, hypertension, hyperlipidemia, coronary heart disease, neurasthenia are had auxiliary curative effect.Fructus Mori has effects such as promoting the production of body fluid to quench thirst, facilitating digestion, help defecation, and proper amount of edible can promote gastric secretion, stimulates enterokinesia and removes scorching.The traditional Chinese medical science thinks that Fructus Mori is sweet in flavor and cold in property, has the liver and the kidney tonifying, an effect such as the intestine moistening of promoting the production of body fluid, black hair make eye bright.

Radix Polygoni Multiflori:

[meridian distribution of property and flavor] is bitter, sweet, puckery, and temperature is returned liver, the heart, kidney channel.

[function cures mainly] detoxifcation, eliminating carbuncle, loosening bowel to relieve constipation.Be used for the scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia has therapeutical effect to diseases such as neurasthenia, poliosis, alopecia, anemias, therefore, and delaying sanility, building body, health care heart.

Bee pollen: anti-prostatic hyperplasia, antiinflammatory anti-hypoxia, enhancing immunomodulating, defying age, blood fat reducing and looks improving and the skin nourishing etc.1. strengthen the human body comprehensive immunologic function: bee pollen polysaccharide can activating macrophage engulfs activity, improves the human body resistance against diseases.2. anti-aging, beautification function: bee pollen belongs to the cosmetics of trophism, and compositions such as the VE in the pollen, superoxide dismutase (SOD), selenium can moisten the nutrition skin, recovers the elasticity of skin and bright and clean.Inositol in the pollen can make the poliosis blackening, and alopecia is gradually given birth to, and keeps hair pitch-black beautiful.3. prevent and treat brain cardiovascular disease: the flavone compound in the pollen can effectively be removed the deposition of fat on the blood vessel wall, thereby plays vessel softening and blood fat reducing.4. prevent and treat prostatosis: pollen is prostatitic jinx, with Pollen Brassicae campestris, pollen of Semen Fagopyri Esculenti best results.Active drug-QIANLIEKANG that China controls prostatosis is raw material with pollen.5. fat-reducing: take bee pollen and can absorb enough nutrition, cause satietion.Simultaneously, the fat of the lecithin incendivity surplus in the pollen reaches the purpose of fat-reducing.6. regulate gastrointestinal function: pollen has many sterilization components, can kill escherichia coli etc., and can prevent treating constipation.7. hepatoprotective: the flavone compound in the pollen can prevent the deposition of fat on liver equally.8. nervous system regulation, hypnotic.9. auxiliary treatment other diseases: pollen to anemia, diabetes, improve memory, climacteric obstacle etc. better effects arranged.10. auxiliary treatment prostatosis: the scalable male endocrine, recover bladder urethral smooth muscle function.

Caulis Echinopsis Multiplicis:

[nature and flavor] are sweet light, and are flat.1. " Fujian traditional herbal medicine ": " sweet, cold." 2. " Luchuan book on Chinese herbal medicine ": " cold in nature, little acid " is " Hunan medicine will " 3.: " light, flat.”?　　

[function cures mainly] controls the cough due to lung-heat, sputum mixed with blood, carbuncle, burn.1. " Fujian traditional herbal medicine ": " laxation, pathogenic fire purging, eliminating carbuncle." 2. " Luchuan book on Chinese herbal medicine ": " lung that clears away heart-fire, hemostasis.Control the cough due to lung-heat, sputum mixed with blood." 3. " Hunan medicine will ": " damp eliminating is brought down a fever for reducing swelling and alleviating pain, promoting flow of QI and blood, granulation promoting.”?　　

Herba Solidaginis:

[meridian distribution of property and flavor] is hot, bitter, and be flat.Go into liver, gallbladder two warps.

[function] wind and heat dispersing, anti-inflammation.Be used for the anemopyretic cold headache, (wind and cold is avoided) heat-clearing and toxic substances removing, detumescence is except pain.Upper respiratory tract infection, tonsillitis, laryngopharynx swelling and pain, bronchitis, pneumonia, the pulmonary tuberculosis hemoptysis, anxious, chronic nephritis, infantile malnutrition, traumatic injury is controlled in external, venom, sore swollen toxin, mastitis, 1, antibacterial action: decoct external to staphylococcus aureus (cause suppurate scorching, skin scabies carbuncle, infantile bronchitis) more, bacillus pyocyaneus (pneumonia), dysentery (acute bacillary dysentery), (long-term careful usefulness is avoided in the intestinal injury to Bacillus typhi, easily hemorrhage), Diplococcus pneumoniae (lobar pneumonia), Jia Xingrongxuexinglianqiujun (tonsillitis) and red moss bacterium, Candida albicans (belongs to fungus and causes fungal infection of hand and foot, tinea unguium, tinea pedis, women's colpitis mycotica) inhibitory action is all arranged.

Resina Ferulae:

Acrid in the mouth, temperature, the detumescence of regulating the flow of vital energy is arranged, invigorate blood circulation disappear tired, eliminate the phlegm and the effect of excitor nerve.Uygur medicine survive useful its anthelmintic, treatment vitiligo and traditional method;

Nature and flavor: bitter, hot, temperature.

Gui Jing: return kidney, stomach warp.

Effect: removing food stagnancy, the painful abdominal mass of loosing, parasite killing.Be used for meat stagnation, blood stasis note of the ancient Chinese abdominal mass, mass in abdomen, abdominal pain due to worm stagnation.

Calomelas:

[nature and flavor] suffering, cold, poisonous.1. " the good book on Chinese herbal medicine of helping ": " suffering, cold, nontoxic." 2. " Elementary Medicine ": " is poisonous." 3. " Bencao Congxin ": " is hot cold and dry, poisonous."

[return through] goes into liver, kidney channel.1. " beautiful Chinese catalpa medicine solution ": " go into kidney meridian, liver channel of foot-Jueyin." 2. " book on Chinese herbal medicine is new again ": go into liver, lung two warps.

[function] parasite killing, counteracting toxic substances, diuretic, relieving constipation.Control scabies, scrofula, syphilis, primary sore, skin ulcer, edema, tympanites, defecation is closed.1. supplement to the Herbal: " logical large intestine changes children's's infantile malnutrition and scrofula, kills wine acne on skin ulcer copperworm and the nose, wind skin ulcer pruritus." 2. amplification on Canon of Materia Medica: " saliva medicine and children's's saliva tide, Chi Zong down used more." 3. Zhang Yuansu: " promoting diuresis to alleviate water retention goes in the bladder dirt greasy." 4. " Elementary Medicine ": " consumer edema, hemostasis dysentery is told wind saliva.It is stagnant that " 5. " detailed outline ": " controls sputum, edema tympanites, skin infection." 6. " book on Chinese herbal medicine just ": " controls all skin infection of scrofula, removing the necrotic tissue meat, tissue regeneration promoting meat.

The Lithargyrum:

[meridian distribution of property and flavor] property is salty, hot, flat, poisonous; Go into liver, spleen channel.

[effect] detumescence, parasite killing, convergence are anticorrosion, eliminating phlegm down to arrest convulsion, through test to multiple pathogenic dermatophytes, inhibitory action is in various degree arranged, can shrink the blood vessel at mucosa and ulcer place, secretion is reduced, and effect such as protecting from infection of antiinflammatory is arranged.

Mosla dianthera:

[nature and flavor] suffering, temperature.　

[effect] dispeled the wind and delivered, and dampness removing is antipruritic.Be used for headache due to common cold, tonsillitis, heatstroke, Peptic Ulcers, dysentery; Eczema is controlled in external, miliaria, skin pruritus, furuncle, centipete bite.

The specific embodiment:

Embodiment 1, prescription:

Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 1g, Herba seu Flos Convolvuli arvensis 1g, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 1g, Cortex Dictamni 1g, Radix Angelicae Dahuricae 1g, Folium Lonicerae Confusae 1g, Fructus Xanthii 10g, Cortex erythrinae 10g, Herba Andrographis 10g, Herba Euphorbiae Helioscopiae 10g, Gotu Kola 10g, Herba Polygoni Avicularis 10g, Amylum Nelumbinis Rhizomatis 20g, Fructus Mori 20g, Radix Polygoni Multiflori 20g, Semen Sesami Nigrum 20g, bee pollen 20g, Caulis Echinopsis Multiplicis 20g, Fructus Atriplicis Sibiricae 30g, Herba Solidaginis 30g, Resina Ferulae 30g, Calomelas 30g, Lithargyrum 30g, Mosla dianthera 30g;

Preparation method:

By formula proportion with above composition extract routinely, separate, dry, pulverize, composite in proportion, can be made into tablet, capsule, oral formulations, spray, liniment after mix homogeneously, the drying.

Embodiment 2, prescription:

Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 2g, Herba seu Flos Convolvuli arvensis 2g, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 2g, Cortex Dictamni 2g, Radix Angelicae Dahuricae 2g, Folium Lonicerae Confusae 2g, Fructus Xanthii 12g, Cortex erythrinae 12g, Herba Andrographis 12g, Herba Euphorbiae Helioscopiae 12g, Gotu Kola 12g, Herba Polygoni Avicularis 12g, Amylum Nelumbinis Rhizomatis 22g, Fructus Mori 22g, Radix Polygoni Multiflori 22g, Semen Sesami Nigrum 22g, bee pollen 22g, Caulis Echinopsis Multiplicis 22g, Fructus Atriplicis Sibiricae 32g, Herba Solidaginis 32g, Resina Ferulae 32g, Calomelas 32g, Lithargyrum 32g, Mosla dianthera 32g.

Preparation method is identical with embodiment 1.

Embodiment 3, prescription:

Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 5g, Herba seu Flos Convolvuli arvensis 5g, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 5g, Cortex Dictamni 5g, Radix Angelicae Dahuricae 5g, Folium Lonicerae Confusae 5g, Fructus Xanthii 15g, Cortex erythrinae 15g, Herba Andrographis 15g, Herba Euphorbiae Helioscopiae 15g, Gotu Kola 15g, Herba Polygoni Avicularis 15g, Amylum Nelumbinis Rhizomatis 25g, Fructus Mori 25g, Radix Polygoni Multiflori 25g, Semen Sesami Nigrum 25g, bee pollen 25g, Caulis Echinopsis Multiplicis 25g, Fructus Atriplicis Sibiricae 35g, Herba Solidaginis 35g, Resina Ferulae 35g, Calomelas 35g, Lithargyrum 35g, Mosla dianthera 35g.

Preparation method is identical with embodiment 1.

Embodiment 4, prescription:

Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 8g, Herba seu Flos Convolvuli arvensis 8g, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 8g, Cortex Dictamni 8g, Radix Angelicae Dahuricae 8g, Folium Lonicerae Confusae 8g, Fructus Xanthii 18g, Cortex erythrinae 18g, Herba Andrographis 18g, Herba Euphorbiae Helioscopiae 18g, Gotu Kola 18g, Herba Polygoni Avicularis 18g, Amylum Nelumbinis Rhizomatis 28g, Fructus Mori 28g, Radix Polygoni Multiflori 28g, Semen Sesami Nigrum 28g, bee pollen 28g, Caulis Echinopsis Multiplicis 28g, Fructus Atriplicis Sibiricae 38g, Herba Solidaginis 38g, Resina Ferulae 38g, Calomelas 38g, Lithargyrum 38g, Mosla dianthera 38g.

Preparation method is identical with embodiment 1.

Embodiment 5, prescription:

Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 10g, Herba seu Flos Convolvuli arvensis 10g, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 10g, Cortex Dictamni 10g, Radix Angelicae Dahuricae 10g, Folium Lonicerae Confusae 10g, Fructus Xanthii 20g, Cortex erythrinae 20g, Herba Andrographis 20g, Herba Euphorbiae Helioscopiae 20g, Gotu Kola 20g, Herba Polygoni Avicularis 20g, Amylum Nelumbinis Rhizomatis 30g, Fructus Mori 30g, Radix Polygoni Multiflori 30g, Semen Sesami Nigrum 30g, bee pollen 30g, Caulis Echinopsis Multiplicis 30g, Fructus Atriplicis Sibiricae 40g, Herba Solidaginis 40g, Resina Ferulae 40g, Calomelas 40g, Lithargyrum 0g, Mosla dianthera 40g;

Preparation method:

By formula proportion with above composition extract routinely, separate, dry, pulverize, composite in proportion, can be made into tablet, capsule, oral formulations, spray, liniment after mix homogeneously, the drying.

The pharmacology pharmacodynamic experiment:

1, acute toxicity test

The application mice carries out acute toxicity testing and shows: mice oral administration gavage Chinese medicine preparation of the present invention, under 488.8g crude drug/kg dosage, the light activity minimizing appears in mice after the administration, recover normal about 1 hour, observed 7 days continuously after the administration, none animal dead, its overall health of patients, diet, to take the photograph water, urine and body weight gain all normal, and experimental result shows: the maximum dosage-feeding of mice oral administration gavage Chinese medicine preparation capsule of the present invention is 488.8g crude drug/kg/d (LD 50＞488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; Press weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is clinical disease pig, horse, cattle 4888 times.Point out this medicine acute toxicity low, clinical drug safety.

2, long term toxicity test

Select the SD rat for use, give variable concentrations (18.0,6.0, the Chinese medicine preparation of the present invention of 2.0g crude drug/kg), irritate stomach every day once, continuous 90 days, respectively organized 1/2 animal (male and female half and half) extremely that lives in 24 hours after the last administration, all the other 1/2 animals continuation observation, 2 all backs are extremely alive.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, after the administration 90 days and carry out hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) in 2 weeks of drug withdrawal and index inspections such as blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology.Result of the test shows: preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain be no abnormal variation all; Three dosage groups and matched group hematological examination, blood biochemical are learned, the urine biochemical analysis is all in normal range, do not have significant difference between group; Each is organized the main organs histopathological examination and shows no obvious abnormalities.The These parameters drug withdrawal is not seen change after 2 weeks yet.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test Chinese medicine preparation of the present invention high, medium and low three dosage (18.0,6.0, the 2.0g crude drug/kg) administration in continuous 90 days does not have obvious influence to rat, no clear and definite toxicity target organ and sensitive indicator, the retardance toxic reaction is not seen in the convalescent period observation yet, points out the dosage safety of Chinese medicine preparation clinical practice of the present invention higher.

3, animal local excitation test:

The guinea pig skin hypersensitive test of preparation of the present invention and rat rectal application irritation test.The result shows: skin anaphylactic test, high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg, be equivalent to intend clinical pig, horse, cattle consumption [0.04g (medicated powder)/kg] 20 times, 2.5 times respectively, through the skin administration, there is no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to intend clinical pig, horse, cattle consumption 125,80 times respectively, in official hour, observe mucous membrane of rectum and all do not have phenomenons such as hyperemia, edema, histopathologic examination and blank group be no significant difference relatively, do not see and tangible irritative response occurs, every group of its overall health of patients of part animal of retaining, body weight, breathing, circulation, central nervous system and extremity activity etc., all Non Apparent Abnormality reactions.

Clinical data

Clinical diagnosis

The 1-1 physical data is chosen altogether and is diagnosed as poultry tinea disease 1000 examples, and each embodiment is one group, is divided into 5 groups, every group of each 200 example.

The 1-2 diagnostic criteria

1-2-1 Western medicine diagnose standard reference " veterinary's internal medicine " " and " herbal medicine Clinical Researches of New Drugs guideline " draft.

(1) symptom and sign: it is depressed that spirit appears in the periodicity of prolonged and repeated generation, inappetence, pruritus, lose hair or feathers, after around eyes, ear, abdominal part flushing occurs earlier, bear 2～3 millimeters little yellow fluid bubbles of size, change the whole skin redness after several days into, and very strong hotness is arranged, fervescence to 40 ℃～41 ℃;

(2) case includes that standard is all to meet two veterinary's medical diagnosis on disease standards and the diagnostic criteria of Chinese veterinarian's pattern of syndrome and outside exclusion standard in.

Therapeutic outcome sees Table.

Five groups of healing rates of table 1 are (example) relatively

The invention has the beneficial effects as follows:

The all medicines of the present invention are united utilization, and for the poultry tinea, it is depressed spirit to occur, inappetence, pruritus, the depilation phenomenon therapeutic effect is remarkable, so far, a kind of Chinese medicine preparation for the poultry tinea of evidence, therapeutic effect significantly, have no side effect, have no drug resistance, economical and effective is convenient is worth application, preparation of the present invention can be by stomach acids destroy, directly arrives intestinal and slowly discharges and be absorbed and act on pathogen, and effect is obvious, evidence preparation of the present invention has no side effect, and safety is relieved.

Claims (3)

1. a Chinese medicine preparation that is used for the poultry tinea is characterized in that, is made up of the raw material of following weight portion:

Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 1-10 part, Herba seu Flos Convolvuli arvensis 1-10 part, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 1-10 part, Cortex Dictamni 1-10 part, Radix Angelicae Dahuricae 1-10 part, Folium Lonicerae Confusae 1-10 part, Fructus Xanthii 10-20 part, Cortex erythrinae 10-20 part, Herba Andrographis 10-20 part, Herba Euphorbiae Helioscopiae 10-20 part, Gotu Kola 10-20 part Herba Polygoni Avicularis 10-20 part, Amylum Nelumbinis Rhizomatis 20-30 part, Fructus Mori 20-30 part, Radix Polygoni Multiflori 20-30 part, Semen Sesami Nigrum 20-30 part, bee pollen 20-30 part, Caulis Echinopsis Multiplicis 20-30 part, Fructus Atriplicis Sibiricae 30-40 part, Herba Solidaginis 30-40 part, Resina Ferulae 30-40 part, Calomelas 30-40 part, Lithargyrum 30-40 part, Mosla dianthera 30-40 part;

Preparation method:

By formula proportion with above composition extract routinely, separate, dry, pulverize, composite in proportion, can be made into tablet, capsule, oral formulations, spray, liniment after mix homogeneously, the drying.

2. a kind of Chinese medicine preparation for the poultry tinea according to claim 1 is characterized in that, is made up of the raw material of following weight portion:

Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 2-8 part, Herba seu Flos Convolvuli arvensis 2-8 part, Isodonpubescens (Hemsl.) C. Y. Wuet Hsuan 2-8 part, Cortex Dictamni 2-8 part, Radix Angelicae Dahuricae 2-8 part, Folium Lonicerae Confusae 2-8 part, Fructus Xanthii 12-18 part, Cortex erythrinae 12-18 part, Herba Andrographis 12-18 part, Herba Euphorbiae Helioscopiae 12-18 part, Gotu Kola 12-18 part Herba Polygoni Avicularis 12-18 part, Amylum Nelumbinis Rhizomatis 22-28 part, Fructus Mori 22-28 part, Radix Polygoni Multiflori 22-28 part, Semen Sesami Nigrum 22-28 part, bee pollen 22-28 part, Caulis Echinopsis Multiplicis 22-28 part, Fructus Atriplicis Sibiricae 32-38 part, Herba Solidaginis 32-38 part, Resina Ferulae 32-38 part, Calomelas 32-38 part, Lithargyrum 32-38 part, Mosla dianthera 32-38 part.

3. a kind of Chinese medicine preparation for the poultry tinea according to claim 1 is characterized in that, is made up of the raw material of following weight portion:

5 parts of Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi)s, 5 parts of Herba seu Flos Convolvuli arvensves, 5 parts of Isodonpubescens (Hemsl.) C. Y. Wuet Hsuans, 5 parts of Cortex Dictamni, 5 parts of the Radixs Angelicae Dahuricae, 5 parts of Folium Lonicerae Confusae, 15 parts of Fructus Xanthii, 15 parts of Cortex erythrinaes, 15 parts of Herba Andrographis, 15 parts of Herba Euphorbiae Helioscopiae, Gotu Kola 15 15 parts of Fen, Herba Polygoni Avicularis, 25 parts of Amylum Nelumbinis Rhizomatis, 25 parts in Fructus Mori, 25 parts of Radix Polygoni Multiflori, 25 parts of Semen Sesami Nigrums, 25 parts of bee pollen, 25 parts of Caulis Echinopsis Multipliciss, 35 parts of Fructus Atriplicis Sibiricaees, 35 parts of Herba Solidaginiss, 35 parts of Resina Ferulaes, 35 parts of Calomelass, 35 parts of Lithargyrums, 35 parts of Mosla diantheras.