CN107468957A - Ox skin disease Chinese medicine preparation - Google Patents
Ox skin disease Chinese medicine preparation Download PDFInfo
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Abstract
The invention discloses a kind of ox skin disease Chinese medicine preparation, it is made up of the raw material of following mass fraction:3 10 parts of Radix Angelicae Sinensis, 1 10 parts of frutus cnidii, 1 10 parts of Ligusticum wallichii, 1 10 parts of myrrh, 1 10 parts of the root of Dahurain angelica, 1 10 parts of wild honeysuckle leaf, 10 20 parts of peppermint, 10 20 parts of erythrina bark, 10 20 parts of smilax, 10 20 parts of the red sage root, 30 40 parts of mealy potato, 20 30 parts of mulberry fruit, 20 30 parts of the fleece-flower root, 20 30 parts of Bee Pollen, 10 50 parts of the root bark of shaggy-fruited dittany, 30 40 parts of litharge;Preparation method:By formula rate by routinely extracting and developing, drying, the crushing of above composition, compound in proportion, preparation can be obtained after well mixed, explosion puffing drying.The problem of the invention is intended to provide a kind of therapeutic effect significant ox skin disease Chinese medicine preparation, can effectively solving in the prior art that fungal dermatopathy can not be effected a radical cure thoroughly, and toxic side effect can be produced.
Description
Technical field
The present invention relates to a kind of ox skin disease Chinese medicine preparation.
Background technology
In veterinary clinic practice, dermatomycosis is a kind of very common and multiple disease.After pathomycete excess
Ox-hide skin is invested, skin and hair or toenail, a large amount of propagation is invaded, causes the generation of skin organic disease.Ox dermatomycosis
The course of disease it is long, cure difficult, easily recurrence, and being propagated mutually between animal and animal, person to person, people and animal, cause serious
Public health problem.Its average attack rate is about 10%~40%.The incidence of disease is high, recurrence rate is also high, and oneself is of increasing concern.
Modern medicine believes that, the mycotic main pathogen of ox-hide skin is gypsum sporidiole bacteria, microsporum canis, barber's itch hair tinea
Bacterium and candida albicans etc., its generation and the excessive adhesion, the imbalance of body itself microecological balance, immunity degradation of disease fungus etc. are close
Cut is closed.
At present, people to fungal dermatopathy based on local treatment, for obstinate recurrent case can system application it is anti-
Fungi medicine.1%~2% antimycotic Western medicine such as Miconazole (Da Kening), clotrimazole, ketoconazole or Yikang is most commonly applied outside
Azoles is treated, for the case of obstinate general hair Perhaps immunization functional defect, can be selected system antifungal such as Te Bicaifen, she
Triaconazole is treated.With widely using for antifungal drug, going out for many clinical new pathogenic bacteria and endurance strain is caused
It is existing.Meanwhile fungi and mammalian cell are all eukaryotic, many something in common be present in configuration aspects, after long-term prescription
Often there is larger toxicity to host.Such as the renal toxicity of amphotericin B, the hepatotoxicity wind agitation of imidazoles ketoconazole, Te Bicaifen,
Hepatic lesion caused by Itraconazole etc..For existing antimycotic Western medicine generally existing toxicity is higher and drug resistance problems, find
Efficiently, low toxicity, the antimycotic new drug of wide spectrum are extremely urgent.Therefore in the treatment fungal dermatopathy of research and development high-efficiency low-toxicity
Medicine, to alleviate western medicine fungal infection when drug resistance and toxicity problem it is imperative.
The content of the invention
The invention is intended to provide a kind of ox skin disease Chinese medicine preparation, can effectively solve fungal dermatopathy in the prior art
The problem of can not thoroughly effecting a radical cure, and toxic side effect can be produced.
Patent formula:Ox skin disease Chinese medicine preparation in this programme, is made up of the raw material of following mass fraction:Radix Angelicae Sinensis
3-10 parts, frutus cnidii 1-10 parts, Ligusticum wallichii 1-10 parts, myrrh 1-10 parts, root of Dahurain angelica 1-10 parts, wild honeysuckle leaf 1-10 parts, peppermint 10-20
Part, erythrina bark 10-20 parts, smilax 10-20 parts, red sage root 10-20 parts, mealy potato 30-40 parts, mulberry fruit 20-30 parts, the fleece-flower root
20-30 parts, Bee Pollen 20-30 parts, root bark of shaggy-fruited dittany 10-50 parts, litharge's 30-40 parts;Preparation method:By formula rate will more than into
Divide routinely extracting and developing, drying, crushing, compound in proportion, preparation can be obtained after well mixed, explosion puffing drying.
Compared with prior art, it is an advantage of the invention that:
1st, it is made of a variety of natural materials, is influenced each other the effect of each raw material, mutually collaboration, is effectively prevented with ox
The appearance of psoriasis, it is provided simultaneously with realizing the effect for the treatment of disease.
2nd, the starch that mealy potato etc. contains can be expanded in bulking process so that whole Chinese medicine preparation volume increase,
Density is decreased to less than water, while preparation globality is more preferably more easy to be swallowed, when ox takes, it is only necessary to poured into trough
Water, said preparation is sprinkled into water, preparation can float waterborne, and avoiding that preparation falls can not be complete by ox in the corner of trough
Take, while active ingredient is not easy, by hydrochloric acid in gastric juice erosion damage, directly to reach enteron aisle and slowly discharge and absorbed and act on cause of disease
Body.
3rd, Chinese veterinarian's theory thinks, although the body surface in animal occurs for fungal dermatopathy, has with inherent internal organs, qi and blood
Substantial connection.Visceral dysfunction, channels and collaterals are unfavorable, and qi and blood Kui is stagnant, and wet, the hot, heresy of worm three seizes the opportunity to worm one's way into, and causes local patholoic change.By
Viscous in damp evil, the state of an illness is touching, repeatedly refractory.With the passing of time Tianjin hematozemia is then hindered.Stasis blocking train of thought, cause the not flourish skin of blood.The Chinese traditional treatment disease,
Main selection desinsection is antipruritic, heat-clearing and damp-drying drug agent.Frutus cnidii has antipruritic desinsection, heat-clearing and damp-drying drug, analgesic effect in prescription of the present invention;
The root bark of shaggy-fruited dittany has heat-clearing and damp-drying drug, dispelling wind and arresting itching, detoxicating functions, rubella, eczema, mange caused by main wind-heat wet poison etc.;Smilax
For removing dampness and detoxicating medicine, itching-relieving action can be played, the combination with the red sage root, the root bark of shaggy-fruited dittany has synergy;Ligusticum wallichii has blood-activating and qi-promoting,
Mycostasis;The root of Dahurain angelica has antipyretic, analgesia, anti-inflammatory, improves local blood circulation, promotes the work(of skin cell metabolism
Effect.In addition, urea can change the permeability of animal skin, concentration of the increase medicine in agents area.
Work as the dry root for being classified as umbelliferae angelica in product of the present invention, containing volatile oil, key aroma composition is
Butenoic acid lactones and face hydroxy benzenes pentanone etc., in addition it also containing sucrose and palmitic acid, cupreol and palmitate, nicotinic acid,
Vitamin E, vitamin B12 etc..The warm-natured acrid-sweet flavor of Radix Angelicae Sinensis, there is the effect such as enrich blood, invigorate blood circulation, be antibacterial;Safflower is that feverfew is red
Colored dry tubular flower.Contain carthamin, safflower quinone glucoside, neocarthamin.The warm-natured mildly bitter flavor of safflower is pungent.With invigorate blood circulation, dispel
The effect of stasis of blood relieves pain;The red sage root is the dry root of the labiate red sage root.Fat-soluble a variety of tanshinones of oil-containing and water miscible
The derivative of original pair tea phenol aldehyde and catechol.Red sage root cold nature bitter.Promote with activating blood and removing stasis, menstruction regulating and pain relieving, calming heart and tranquilizing mind
Tissue repair, it is antibacterial the effect of;Myrrh is olive subject plant myrrh and belongs to the factice tree that other plant backbone skin zone oozes out together
Fat.Contain resin, volatile oil, natural gum and amaroid etc..Myrrh is bitter in taste.The effect of with promoting blood circulation and stopping pain, detumescence and promoting granulation.
Peppermint:Treat anemopyretic cold, headache, sore-throat, aphthae, rubella, measles, anti-inflammatory analgetic.
The root bark of shaggy-fruited dittany:
【Meridian distribution of property and flavor】Bitter cold, enter spleen, stomach.
【Function】Clearing heat and detoxicating, dispelling wind and eliminating dampness.For damp and hot sore, rubella, mange, skin scratch, arthritis with fixed pain caused by dampness, jaundice etc.
Disease.
The root of Dahurain angelica:
【Nature and flavor】Pungent, temperature enters lung, spleen, stomach;
【Effect】Control headache, pain in the supra-orbital bone, dentalgia, cold-dampness stomachache, pruitus, mange.
Wild honeysuckle leaf:
【Meridian distribution of property and flavor】It is sweet, cold, enter lung, spleen two passes through;
【Cure mainly】It is clearing heat and detoxicating;Control ulcerative carbuncle, serious case of furuncle, numb acne measles toxicity, infantile malnutrition due to digestive disturbances or intestinalparasites sore, dysentery, skin disease, blood-head.
Mealy potato:
【Nature and flavor】It is sweet, mild-natured.
【Major function】Cure mainly cough with lung heat, irritated thirsty, splenasthenic diarrhea, poor appetite and various blood troubles.Life is ripe
It is edible, cure mainly hot thirsty, scattered silt blood, myogenic.
Erythrina bark:Wind-damp dispelling, degrading the channel, desinsection.Cure mainly:Control arthralgia pain due to rheumatism, dysentery, toothache, mange.
Mulberry fruit:
【Nature and flavor】It is sweet, it is slightly cold;The thoughts of returning home, liver and kidney channel.
【Major function】Liver-kidney Yin deficiency is controlled, sends and takes off, constipation, mesh is dark, tinnitus, former ulcer, articular instability.It has improvement skin
(including scalp) blood supply, nutrition skin, make skin delicate and the effect such as black hair, and can anti-aging.Mulberry fruit is person in middle and old age
People is healthy and strong U.S. face, the good fruit of anti-aging and good medicine.Often eating mulberry fruit can be with improving eyesight, the dry and astringent symptom of relieving eye strain.Mulberry fruit has
There is immunologic enhancement.Mulberry fruit has effect of gain to spleen, has humidification to hemolytic reaction, can prevent that human body artery is hard
Change, skeletal joint hardening, enhance metabolism;Mulberry fruit can promote the growth of erythrocyte, prevent Neuroleptic Leukocytopenia, and to controlling
Treating the illnesss such as diabetes, anaemia, hypertension, high fat of blood, coronary heart disease, neurasthenia has auxiliary curative effect.Mulberry fruit, which has, promotes the production of body fluid only
Yearningly, promote digestion, help the effect such as defecation, proper amount of edible can promote gastric secretion, stimulate enterocinesia and release scorching.The traditional Chinese medical science is recognized
For mulberry fruit is sweet in flavor and cold in property, has liver-kidney tonifying, ease constipation of promoting the production of body fluid, UFA eyesight and other effects.
The fleece-flower root:
【Meridian distribution of property and flavor】It is bitter, sweet, puckery, temperature, Return liver, the heart, kidney channel.
【Major function】Removing toxic substances, disappear carbuncle, relaxes bowel.For scrofula sore carbuncle, rubella itch, dry constipation of intestines;High fat of blood, it is right
The illnesss such as neurasthenia, white hair, alopecia, anaemia have therapeutic action, therefore, delaying sanility, physical fitness, health care heart.
Bee Pollen:Anti-prostatic hyperplasia, anti-inflammatory anti anoxia, enhancing immunological regulation, anti-aging, reducing blood lipid and beautifying face and moistering lotion
Deng.1. strengthen human body comprehensive immunologic function:The phagocytosis activity of bee pollen polysaccharide energy activating macrophage, improve the disease-resistant energy of human body
Power.2. anti-aging, beautification function:The cosmetics of Bee Pollen category trophism, VE, superoxide dismutase (SOD) in pollen,
The compositions such as selenium can moisten nutrition skin, recover the elastic and bright and clean of skin.Inositol in pollen can make white hair blackening, and alopecia is gradually
It is raw, keep hair pitch-black beautiful.3. prevent and treat brain cardiovascular disease:Flavone compound in pollen can be removed effectively on vascular wall
The deposition of fat, so as to act to soften blood vessel and reducing blood lipid.4. prevent and treat prostatic disorders:Pollen is prostatitic gram
Star, with rape pollen, pollen of Semen Fagopyri Esculenti best results.China control prostatic disorders active drug-Qian Lie Kang be exactly using pollen as
Raw material.5. lose weight:Enough nutrition can be absorbed by taking Bee Pollen, cause satietion.Meanwhile the lecithin in pollen is flammable
Superfluous fat is burnt, reaches the purpose of fat-reducing.6. adjust functions of intestines and stomach:Pollen has many sterilization components, can kill Escherichia coli
Deng, and can prevent treating constipation.7. liver protecting:Flavone compound in pollen can equally prevent deposition of the fat on liver.⑧
Nervous system is adjusted, promotes sleep.9. auxiliary treatment other diseases:Pollen is to anaemia, diabetes, improvement memory, climacteric
Obstacle etc. has better effects.10. auxiliary treatment prostatic disorders:Adjustable male endocrine, recovers vesicourethral smooth muscle work(
Energy.
Litharge:
【Meridian distribution of property and flavor】Property is salty, pungent, flat, poisonous;Enter liver, the spleen channel.
【Effect】Detumescence, desinsection, restrain anti-corrosion, promoting expectoration to arrest convulsion, through testing to a variety of pathogenic dermatophytes, have in various degree
Inhibitory action, the blood vessel at mucous membrane and ulcer can be shunk, reduce secretion, and have anti-inflammatory prevent infection etc. effect.
4. pure Chinese medicinal preparation, having and resisting a variety of pathogenic funguses, have no drug resistance generation, is a kind of new, effective solution
Certainly livestock and poultry fungal dermatopathy medication;
5. the characteristics of with Mutiple Targets, pleiotropism, drug resistance during puzzlement western medicine fungal infection can be efficiently solved
And toxic side effect problem, it is the innovation on livestock and poultry Fungal Skin medicine;
6. by medicine preparation into after particle, easy to use, curative effect is fast, and drug effect is obvious, and the medicine is to the excitant of mucous membrane
Gently, have no adverse reaction;
7. prevention and cure rate are high, clinical test is efficient, and effect is better than antibiotic;
8. preparation technology is simple, quality standard is controllable, suitable large-scale production needs, and economic and social benefit is huge.
Reasonable recipe compatibility of the present invention, interaction, both meets theory of traditional Chinese medical science, be adapted to be made again it is interior use preparation, it is effective
In treatment livestock and poultry fungal dermatopathy.
Further, Radix Angelicae Sinensis 4-9 parts, frutus cnidii 3-10 parts, Ligusticum wallichii 2-9 parts, myrrh 1-10 parts, root of Dahurain angelica 1-10 parts, wild honeysuckle
Leaf 1-10 parts, peppermint 10-20 parts, erythrina bark 10-20 parts, smilax 10-20 parts, red sage root 10-20 parts, mealy potato 30-40 parts, mulberry
Mulberry 20-30 parts, fleece-flower root 20-30 parts, Bee Pollen 20-30 parts, root bark of shaggy-fruited dittany 10-50 parts, litharge's 30-40 parts.
Further, 3 parts of Radix Angelicae Sinensis, 1 part of frutus cnidii, 1 part of Ligusticum wallichii, 1 part of myrrh, 1 part of the root of Dahurain angelica, 1 part of wild honeysuckle leaf, peppermint 10
Part, 10 parts of erythrina bark, 10 parts of smilax, 10 parts of the red sage root, 30 parts of mealy potato, 20 parts of mulberry fruit, 20 parts of the fleece-flower root, 20 parts of Bee Pollen,
10 parts of the root bark of shaggy-fruited dittany, 30 parts of litharge.
Further, 10 parts of Radix Angelicae Sinensis, 10 parts of frutus cnidii, 10 parts of Ligusticum wallichii, 10 parts of myrrh, 10 parts of the root of Dahurain angelica, 10 parts of wild honeysuckle leaf, thin
20 parts of lotus, 20 parts of erythrina bark, 20 parts of smilax, 20 parts of the red sage root, 40 parts of mealy potato, 30 parts of mulberry fruit, 30 parts of the fleece-flower root, Bee Pollen 30
Part, 50 parts of the root bark of shaggy-fruited dittany, litharge 40.
Further, 5 parts of Radix Angelicae Sinensis, 6 parts of frutus cnidii, 4 parts of Ligusticum wallichii, 7 parts of myrrh, 3 parts of the root of Dahurain angelica, 5 parts of wild honeysuckle leaf, peppermint 13
Part, 14 parts of erythrina bark, 15 parts of smilax, 17 parts of the red sage root, 33 parts of mealy potato, 24 parts of mulberry fruit, 22 parts of the fleece-flower root, 23 parts of Bee Pollen,
32 parts of the root bark of shaggy-fruited dittany, 33 parts of litharge.
Embodiment
Below by embodiment, the present invention is further detailed explanation:
Embodiment 1:
Ox skin disease Chinese medicine preparation in this programme, is made up of the raw material of following mass fraction:3 grams of Radix Angelicae Sinensis, cnidium monnieri
1 gram of son, 1 gram of Ligusticum wallichii, 1 gram of myrrh, 1 gram of the root of Dahurain angelica, 1 gram of wild honeysuckle leaf, 10 grams of peppermint, 10 grams of erythrina bark, 10 grams of smilax, the red sage root
10 grams, 30 grams of mealy potato, 20 grams of mulberry fruit, 20 grams of the fleece-flower root, 20 grams of Bee Pollen, 10 grams of the root bark of shaggy-fruited dittany, 30 grams of litharge;
Preparation method:By formula rate by routinely extracting and developing, drying, the crushing of above composition, compound, mix in proportion
Preparation can be obtained after closing uniform, explosion puffing drying.
Compared with prior art, it is an advantage of the invention that:
1st, it is made of a variety of natural materials, is influenced each other the effect of each raw material, mutually collaboration, is effectively prevented with ox
The appearance of psoriasis, it is provided simultaneously with realizing the effect for the treatment of disease.
2nd, the starch that mealy potato etc. contains can be expanded in bulking process so that whole Chinese medicine preparation volume increase,
Density is decreased to less than water, while preparation globality is more preferably more easy to be swallowed, when ox takes, it is only necessary to poured into trough
Water, said preparation is sprinkled into water, preparation can float waterborne, and avoiding that preparation falls can not be complete by ox in the corner of trough
Take, while active ingredient will not be destroyed by hydrochloric acid in gastric juice, directly reach enteron aisle and slowly discharge and absorbed and act on pathogen.
3rd, it is the pharmacological effect of each component in the present invention below:
The tuber of stemona:Major function:Radiate inducing diaphoresis, embellish but not dry, can open drop-down gas, clearing lung-heat heat and inducing diaphoresis, for skin mange,
The disease such as eczema, psoriasis, yellow swollen, dermatitis, eczema all over.
Honeysuckle flower:It is clearing heat and detoxicating, dispelling wind and heat from the body.
Peppermint:Treat anemopyretic cold, headache, sore-throat, aphthae, rubella, measles, anti-inflammatory analgetic.
Kuh-seng:Cool blood, relieving heat toxin, scabies leprosy, impetigo poison, pruitus, blood wind tinea sore, detumescence poison, acute purulent lymphadenitis, skin scabies
Itch, wet poison sore.
Golden cypress:Heat-clearing, eliminating dampness, purging intense heat, removing toxic substances, hemorrhoid, red eye, swell pain, aphthae, sore swollen toxin.
The root bark of shaggy-fruited dittany:
【Meridian distribution of property and flavor】Bitter cold, enter spleen, stomach.
【Function】Clearing heat and detoxicating, dispelling wind and eliminating dampness.For damp and hot sore, rubella, mange, skin scratch, arthritis with fixed pain caused by dampness, jaundice etc.
Disease.
The root of Dahurain angelica:
【Nature and flavor】Pungent, temperature enters lung, spleen, stomach;
【Effect】Control headache, pain in the supra-orbital bone, dentalgia, cold-dampness stomachache, pruitus, mange.
Wild honeysuckle leaf:
【Meridian distribution of property and flavor】It is sweet, cold, enter lung, spleen two passes through;
【Cure mainly】It is clearing heat and detoxicating;Control ulcerative carbuncle, serious case of furuncle, numb acne measles toxicity, infantile malnutrition due to digestive disturbances or intestinalparasites sore, dysentery, skin disease, blood-head.
Gotu Kola:
【Nature and flavor】It is bitter, pungent, it is cool;It is very toxic.
【Major function】Wind-dispelling, removing toxic substances, desinsection.External application treating rheumatic arthritis, skin are itched, and kill maggot, wriggler, and go out nail
Spiral shell, malicious mouse.
Mealy potato:
【Nature and flavor】It is sweet, mild-natured.
【Major function】Cure mainly cough with lung heat, irritated thirsty, splenasthenic diarrhea, poor appetite and various blood troubles.Life is ripe
It is edible, cure mainly hot thirsty, scattered silt blood, myogenic.
Erythrina bark:Wind-damp dispelling, degrading the channel, desinsection.Cure mainly:Control arthralgia pain due to rheumatism, dysentery, toothache, mange.
Herba Andrographitis:
【Meridian distribution of property and flavor】Hardship, tremble with fear, the thoughts of returning home, lung, large intestine, bladder warp.
【Major function】It is clearing heat and detoxicating, cool blood, detumescence.For cold, fever, abscess of throat, aphthae, pertussis overstrain cough,
Dysentery, puckery pain of heat gonorrhea, carbuncle swells sore, venomous snake bite, treatment neurodermatitis, eczema.
Pivot stores:
Hardship, it is slightly cold.Return bladder warp.The product hardship falls row, tonneau bladder, bitter dry and can desinsection removing dampness to relieve itching, is mainly used in
Leaching pain and eczema.
1. promoting diuresis for stranguria is used for damp-heat gonorrhoea, urinary infection, calculus, blood urine etc. can be treated.
2. desinsection is antipruritic to treat the parasitic diseases such as pinworm.Also can decoct soup washout treatment skin sore rash, itch.
3. dysentery is controlled, jaundice.
Mulberry fruit:
【Nature and flavor】It is sweet, it is slightly cold;The thoughts of returning home, liver and kidney channel.
【Major function】Liver-kidney Yin deficiency is controlled, sends and takes off, constipation, mesh is dark, tinnitus, former ulcer, articular instability.It has improvement skin
(including scalp) blood supply, nutrition skin, make skin delicate and the effect such as black hair, and can anti-aging.Mulberry fruit is person in middle and old age
People is healthy and strong U.S. face, the good fruit of anti-aging and good medicine.Often eating mulberry fruit can be with improving eyesight, the dry and astringent symptom of relieving eye strain.Mulberry fruit has
There is immunologic enhancement.Mulberry fruit has effect of gain to spleen, has humidification to hemolytic reaction, can prevent that human body artery is hard
Change, skeletal joint hardening, enhance metabolism;Mulberry fruit can promote the growth of erythrocyte, prevent Neuroleptic Leukocytopenia, and to controlling
Treating the illnesss such as diabetes, anaemia, hypertension, high fat of blood, coronary heart disease, neurasthenia has auxiliary curative effect.Mulberry fruit, which has, promotes the production of body fluid only
Yearningly, promote digestion, help the effect such as defecation, proper amount of edible can promote gastric secretion, stimulate enterocinesia and release scorching.The traditional Chinese medical science is recognized
For mulberry fruit is sweet in flavor and cold in property, has liver-kidney tonifying, ease constipation of promoting the production of body fluid, UFA eyesight and other effects.
The fleece-flower root:
【Meridian distribution of property and flavor】It is bitter, sweet, puckery, temperature, Return liver, the heart, kidney channel.
【Major function】Removing toxic substances, disappear carbuncle, relaxes bowel.For scrofula sore carbuncle, rubella itch, dry constipation of intestines;High fat of blood, it is right
The illnesss such as neurasthenia, white hair, alopecia, anaemia have therapeutic action, therefore, delaying sanility, physical fitness, health care heart.
Bee Pollen:Anti-prostatic hyperplasia, anti-inflammatory anti anoxia, enhancing immunological regulation, anti-aging, reducing blood lipid and beautifying face and moistering lotion
Deng.1. strengthen human body comprehensive immunologic function:The phagocytosis activity of bee pollen polysaccharide energy activating macrophage, improve the disease-resistant energy of human body
Power.2. anti-aging, beautification function:The cosmetics of Bee Pollen category trophism, VE, superoxide dismutase (SOD) in pollen,
The compositions such as selenium can moisten nutrition skin, recover the elastic and bright and clean of skin.Inositol in pollen can make white hair blackening, and alopecia is gradually
It is raw, keep hair pitch-black beautiful.3. prevent and treat brain cardiovascular disease:Flavone compound in pollen can be removed effectively on vascular wall
The deposition of fat, so as to act to soften blood vessel and reducing blood lipid.4. prevent and treat prostatic disorders:Pollen is prostatitic gram
Star, with rape pollen, pollen of Semen Fagopyri Esculenti best results.China control prostatic disorders active drug-Qian Lie Kang be exactly using pollen as
Raw material.5. lose weight:Enough nutrition can be absorbed by taking Bee Pollen, cause satietion.Meanwhile the lecithin in pollen is flammable
Superfluous fat is burnt, reaches the purpose of fat-reducing.6. adjust functions of intestines and stomach:Pollen has many sterilization components, can kill Escherichia coli
Deng, and can prevent treating constipation.7. liver protecting:Flavone compound in pollen can equally prevent deposition of the fat on liver.⑧
Nervous system is adjusted, promotes sleep.9. auxiliary treatment other diseases:Pollen is to anaemia, diabetes, improvement memory, climacteric
Obstacle etc. has better effects.10. auxiliary treatment prostatic disorders:Adjustable male endocrine, recovers vesicourethral smooth muscle work(
Energy.
Calomel mercurous chloride:
【Nature and flavor】It is pungent, tremble with fear, it is poisonous.①《It is good to help book on Chinese herbal medicine》:" it is pungent, it is cold, it is nontoxic."②《Elementary Medicine》:It is " poisonous."③《This
Grass is from new》:" it is pungent cold and dry, it is poisonous."
【Channel tropism】Enter liver and kidney channel.①《Beautiful Chinese catalpa medicine solution》:" enter kidney meridian, the liver channel of foot-Jueyin."②《Book on Chinese herbal medicine is new again》:Enter
Liver, lung two pass through.
【Function】Desinsection, attack poison, Li Shui, defaecation.Control mange, scrofula, syphilis, chancre, skin ulcer, oedema, tympanites, greatly
Anuria.①《Bencao Shiyi》:" logical large intestine, turns children's infantile malnutrition due to digestive disturbances or intestinalparasites and scrofula, kills wine Cha on sore copperworm and nose, wind sore itch."②
《Amplification on Materia Medica》:" simultaneously children's saliva tide, Chi Zong uses lower saliva medicine." 3. Zhang Yuansu:" clean mansion, go dirt in bladder greasy."④《Medical science
Introduction》:" consumer edema, dysentery of stopping blooding, tells wind saliva."⑤《Detailed outline》:" control sputum to stagnate, oedema tympanites, carbuncle."⑥《Book on Chinese herbal medicine is just》:"
The all carbuncles of scrofula are controlled, remove slough, raw new meat.
Litharge:
【Meridian distribution of property and flavor】Property is salty, pungent, flat, poisonous;Enter liver, the spleen channel.
【Effect】Detumescence, desinsection, restrain anti-corrosion, promoting expectoration to arrest convulsion, through testing to a variety of pathogenic dermatophytes, have in various degree
Inhibitory action, the blood vessel at mucous membrane and ulcer can be shunk, reduce secretion, and have anti-inflammatory prevent infection etc. effect.
Mosla dianthera:
【Nature and flavor】It is pungent, temperature.
【Effect】Wind-dispelling is delivered, removing dampness through diuresis and relieving itching.For cold headache, tonsillitis, heatstroke, canker, dysentery;External application is controlled
Eczema, prickly heat, pruitus, boil, centipde-bite.
Embodiment 2:
With differing only in for embodiment 1:5 grams of Radix Angelicae Sinensis, 6 grams of frutus cnidii, 4 grams of Ligusticum wallichii, 7 grams of myrrh, 3 grams of the root of Dahurain angelica, soil silver
5 grams of floral leaf, 13 grams of peppermint, 14 grams of erythrina bark, 15 grams of smilax, 17 grams of the red sage root, 33 grams of mealy potato, 24 grams of mulberry fruit, the fleece-flower root 22
Gram, 23 grams of Bee Pollen, 32 grams of the root bark of shaggy-fruited dittany, 33 grams of litharge.
Embodiment 3:
With differing only in for embodiment 1:10 grams of Radix Angelicae Sinensis, 10 grams of frutus cnidii, 10 grams of Ligusticum wallichii, 10 grams of myrrh, 10 grams of the root of Dahurain angelica,
10 grams of wild honeysuckle leaf, 20 grams of peppermint, 20 grams of erythrina bark, 20 grams of smilax, 20 grams of the red sage root, 40 grams of mealy potato, 30 grams of mulberry fruit, He Shou
30 grams of crow, 30 grams of Bee Pollen, 50 grams of the root bark of shaggy-fruited dittany, 40 grams of litharge.
Pharmacology pharmacodynamic is tested:
1st, acute toxicity test
Application mouse carries out acute toxicity testing and shown:The Chinese medicine preparation of the Mouse oral gavage present invention, gives birth in 488.8g
Under medicine/kg dosage, there is light activity reduction in mouse after administration, recovers within 1 hour or so normal, Continuous Observation 7 days, nothing after administration
One animal dead, its overall health of patients, diet, to take the photograph water, urine and body weight increase normal, test result indicates that:Mouse oral fills
The maximum dosage-feeding of the Traditional Chinese medicine preparation capsule agent of the stomach present invention is 488.8g crude drugs/kg/d (the > 488.8g crude drugs of LD 50/kg).
The daily clinical application total amount of Chinese medicine preparation of the present invention is 0.1g crude drugs/kg/d;By batheroom scale, the Chinese medicine of the mouse stomach present invention
The dosis tolerata of preparation be clinical sick pig, horse, 4888 times of ox.Prompt the medicine acute toxicity low, clinical application safety.
2nd, long term toxicity test
From SD rats, the Chinese medicine preparation of the invention of various concentrations (20.0,8.0,4.0g crude drugs/kg) is given, daily
Once, continuous 90 days, 24 hours each groups are lived after last dose killed 1/2 animal (male and female half and half) to gavage, and remaining 1/2 animal continues to see
Work is killed after examining 2 weeks.Outward appearance, general behavior, food ration, the changes of weight of animal are observed during experiment, 90 days and drug withdrawal 2 after administration
Zhou Jinhang hematologies (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu,
BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, the index checking such as Histopathology.Result of the test table
It is bright:Invention formulation is good in high, medium and low dosage group animal general state, appearance sign, behavioral activity, food-intake and body weight
Increase change without exception;Three dosage groups and control group hematological examination, blood biochemical analysis, urine biochemical analysis are normal
Scope, without significant difference between group;Each group main organs histopathological examination is shown no obvious abnormalities.After These parameters are discontinued 2 weeks
Also change is had no.This experiment dosage is respectively the 200 of clinical medicine dose, 80,40 times, according to the result of the test present invention's
Chinese medicine preparation has no significant effect in high, medium and low three dosage (20.0,8.0,4.0g crude drugs/kg) administration in continuous 90 days to rat,
Without clear and definite toxicity target organ and sensitive indicator, convalescence observation also has no retardance toxic reaction, prompts the Chinese medicine of the present invention
The dose safety of preparation clinical practice is higher.
3rd, animal local excitation is tested:
The allergic reaction on guinea pigs and Rat-rectum medication irritation test of invention formulation.As a result show:Skin mistake
Quick experiment, high dose group 1.0g (medicinal powder)/kg, low dose group 0.125g (medicinal powder)/kg, is respectively equivalent to intend clinical pig, horse, ox
25 times, 3 times of dosage [0.04g (medicinal powder)/kg], through percutaneous drug delivery, it is showed no animal and produces allergy;Rectal application stimulates
Property experiment high dose group 6.0g (medicinal powder)/kg, low dose group 3.6g (medicinal powder)/kg, be respectively equivalent to intend clinical pig, horse, Niu Yong
150,90 times of amount, phenomena such as mucous membrane of rectum is without hyperemia, oedema, histopathologic examination and sky are observed within the defined time
White control group compares no significant difference, has no obvious irritative response occur, its overall health of patients of the Some Animals of every group of retention,
Body weight, breathing, circulation, central nervous system and four limbs activity etc., equal Non Apparent Abnormality reaction.
Clinical diagnosis
1-1 general information is chosen altogether is diagnosed as psoriasis disease 200, and each embodiment is one group, and additional one group of control group is not
Using preparation, 4 groups altogether, every group each 50.
1-2 diagnostic criteria
1-2-1 Western medicine diagnostic criteria references《Animal doctor's clinical practice》" and《Herbal medicine Clinical Researches of New Drugs guideline》Draft.
(1) symptom and sign:It is depressed that spirit occurs in the periodicity of prolonged and repeated generation, poor appetite, itch, depilation,
Around eyes, ear, belly first occur bearing the micro- yellow water bubble of 2~3 mm in size after flush, it is red to be changed into whole skin after a few days
It is swollen, and have very strong thermal sensation, body temperature is increased to 40 DEG C~41 DEG C;
(2) case inclusive criteria is all meets two veterinary conditions diagnostic criteria and Chinese veterinarian's card type diagnostic criteria and is excluding to mark
It is accurate outer.
Treatment results are shown in Table.
1 five groups of healing rates of table compare (example)
Group | Cure quantity | Healing rate |
Control group | 50 | 2% |
Embodiment 1 | 50 | 96% |
Embodiment 2 | 50 | 94% |
Embodiment 3 | 50 | 98% |
The beneficial effects of the invention are as follows:
The all medicine conjunctive uses of the present invention, for psoriasis, there is spiritual depressed, poor appetite, itch, depilation phenomenon treatment
Significant effect, so far, experiment prove it is a kind of prevent, the ox Chinese medicine preparation for the treatment of psoriasis, therapeutic effect is notable, nontoxic secondary makees
With having no drug resistance, economical and effective is conveniently worth application, invention formulation will not destroy by hydrochloric acid in gastric juice, directly reach enteron aisle and delay
On The Drug Release is simultaneously absorbed and acts on pathogen, positive effect, and experiment proves that invention formulation has no toxic side effect, safe and secure.
Above-described is only embodiments of the invention, and the general knowledge such as known concrete structure and characteristic is not made herein in scheme
Excessive description., can be with the premise of inventive formulation is not departed from it should be pointed out that for those skilled in the art
Several modifications and improvements are made, these should also be considered as protection scope of the present invention, and these are implemented all without the influence present invention
Effect and practical applicability.The scope of protection required by this application should be based on the content of the claims, in specification
The records such as embodiment can be used for the content for explaining claim.
Claims (5)
1. N with skin disease Chinese medicine preparation, it is characterised in that be made up of the raw material of following mass fraction:Radix Angelicae Sinensis 3-10 parts, snake
Machine tool 1-10 parts, Ligusticum wallichii 1-10 parts, myrrh 1-10 parts, root of Dahurain angelica 1-10 parts, wild honeysuckle leaf 1-10 parts, peppermint 10-20 parts, erythrina bark
10-20 parts, smilax 10-20 parts, red sage root 10-20 parts, mealy potato 30-40 parts, mulberry fruit 20-30 parts, fleece-flower root 20-30 parts, honeybee
Pollen 20-30 parts, root bark of shaggy-fruited dittany 10-50 parts, litharge's 30-40 parts;Preparation method:Above composition is routinely carried by formula rate
Take, separate, dry, crush, compound in proportion, preparation can be obtained after well mixed, explosion puffing drying.
2. ox according to claim 1 skin disease Chinese medicine preparation, it is characterised in that Radix Angelicae Sinensis 4-9 parts, frutus cnidii 3-10
Part, Ligusticum wallichii 2-9 parts, myrrh 1-10 parts, root of Dahurain angelica 1-10 parts, wild honeysuckle leaf 1-10 parts, peppermint 10-20 parts, erythrina bark 10-20 parts,
Smilax 10-20 parts, red sage root 10-20 parts, mealy potato 30-40 parts, mulberry fruit 20-30 parts, fleece-flower root 20-30 parts, Bee Pollen 20-30
Part, root bark of shaggy-fruited dittany 10-50 parts, litharge's 30-40 parts.
3. ox according to claim 1 skin disease Chinese medicine preparation, it is characterised in that 3 parts of Radix Angelicae Sinensis, 1 part of frutus cnidii, Ligusticum wallichii
1 part, 1 part of myrrh, 1 part of the root of Dahurain angelica, 1 part of wild honeysuckle leaf, 10 parts of peppermint, 10 parts of erythrina bark, 10 parts of smilax, 10 parts of the red sage root, potato
30 parts of powder, 20 parts of mulberry fruit, 20 parts of the fleece-flower root, 20 parts of Bee Pollen, 10 parts of the root bark of shaggy-fruited dittany, 30 parts of litharge.
4. ox according to claim 1 skin disease Chinese medicine preparation, it is characterised in that 10 parts of Radix Angelicae Sinensis, 10 parts of frutus cnidii, river
10 parts of rhizome of chuanxiong, 10 parts of myrrh, 10 parts of the root of Dahurain angelica, 10 parts of wild honeysuckle leaf, 20 parts of peppermint, 20 parts of erythrina bark, 20 parts of smilax, the red sage root 20
Part, 40 parts of mealy potato, 30 parts of mulberry fruit, 30 parts of the fleece-flower root, 30 parts of Bee Pollen, 50 parts of the root bark of shaggy-fruited dittany, 40 parts of litharge.
5. ox according to claim 2 skin disease Chinese medicine preparation, it is characterised in that 5 parts of Radix Angelicae Sinensis, 6 parts of frutus cnidii, Ligusticum wallichii
4 parts, 7 parts of myrrh, 3 parts of the root of Dahurain angelica, 5 parts of wild honeysuckle leaf, 13 parts of peppermint, 14 parts of erythrina bark, 15 parts of smilax, 17 parts of the red sage root, potato
33 parts of powder, 24 parts of mulberry fruit, 22 parts of the fleece-flower root, 23 parts of Bee Pollen, 32 parts of the root bark of shaggy-fruited dittany, 33 parts of litharge.
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CN103251713A (en) * | 2013-06-05 | 2013-08-21 | 山东新希望六和集团有限公司 | Traditional Chinese medicine preparation for treating livestock psoriasis |
CN105267800A (en) * | 2015-11-18 | 2016-01-27 | 信阳农林学院 | Traditional Chinese medicine ointment for preventing and treating fungal skin diseases of livestock and poultry |
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CN103251713A (en) * | 2013-06-05 | 2013-08-21 | 山东新希望六和集团有限公司 | Traditional Chinese medicine preparation for treating livestock psoriasis |
CN105267800A (en) * | 2015-11-18 | 2016-01-27 | 信阳农林学院 | Traditional Chinese medicine ointment for preventing and treating fungal skin diseases of livestock and poultry |
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