CN102688315A - Medicine for treating acne and preparation method thereof - Google Patents
Medicine for treating acne and preparation method thereof Download PDFInfo
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- CN102688315A CN102688315A CN2012102151219A CN201210215121A CN102688315A CN 102688315 A CN102688315 A CN 102688315A CN 2012102151219 A CN2012102151219 A CN 2012102151219A CN 201210215121 A CN201210215121 A CN 201210215121A CN 102688315 A CN102688315 A CN 102688315A
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- 206010000496 acne Diseases 0.000 title claims abstract description 32
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 229940079593 drug Drugs 0.000 title claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000007788 liquid Substances 0.000 claims abstract description 5
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000008213 purified water Substances 0.000 claims abstract description 4
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- 238000000034 method Methods 0.000 claims description 5
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- 239000002671 adjuvant Substances 0.000 claims description 3
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- 239000000203 mixture Substances 0.000 claims description 3
- 238000004321 preservation Methods 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 239000006228 supernatant Substances 0.000 claims description 3
- 229940126680 traditional chinese medicines Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 206010007247 Carbuncle Diseases 0.000 abstract description 2
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 244000111489 Gardenia augusta Species 0.000 abstract 1
- 235000018958 Gardenia augusta Nutrition 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 1
- 241001131629 Lancea Species 0.000 abstract 1
- 235000006679 Mentha X verticillata Nutrition 0.000 abstract 1
- 235000002899 Mentha suaveolens Nutrition 0.000 abstract 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 abstract 1
- 244000248825 Peltandra virginica Species 0.000 abstract 1
- 235000001188 Peltandra virginica Nutrition 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 240000004534 Scutellaria baicalensis Species 0.000 abstract 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
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- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 1
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- 239000004098 Tetracycline Substances 0.000 description 1
- 240000003864 Ulex europaeus Species 0.000 description 1
- 229960003473 androstanolone Drugs 0.000 description 1
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- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
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- 235000009566 rice Nutrition 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 210000003859 smegma Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
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- 239000003826 tablet Substances 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicine for treating acne and a preparation method of the medicine for treating acne. The preparation method comprises the steps of: adding water in angelica, radix paeoniae alba, radix bupleuri, tuckahoe, Astraolylis lancea formalyrata, mint, cortex moutan, cape jasmine, baikal skullcap root, radix paeoniae rubra and liquorice, and decocting to obtain decoction, concentrating the decoction, adding common auxiliary mateirals, adding purified water until the raw medicine content is 1g/ml, encapsulating and sterilizing to prepare an oral liquid preparation. The medicine for treating acne disclosed by the invention has the functions of clearing away heat and toxic materials, eliminating carbuncle and removing stasis. As shown in clinic observation, the efficacy of the medicine is 80%. The medicine for treating acne disclosed by the invention is natural, pure, safe, non-toxic and free from dependency.
Description
Technical field
The present invention relates to a kind of medicine of treating acne, particularly a kind of is the Chinese medicine of the treatment acne of crude drug preparation with Chinese medicine.The invention still further relates to the method for preparing of this medicine.
Background technology
Acne is commonly called as " comedo ", is " pimples " " acne " " whelk " " skin sore " etc. again, is modal pilosebaceous chronic inflammatory disease dermatoses.Because of the obstruction of sebaceous gland duct and pore, due to the sebum outflow is not smooth.Acne is a kind of multifactor disease that causes; Having under the condition of inherited genetic factors, the action of microorganisms such as corynebacterium acnes that androgen secretion increases in (especially the dihydrotestosterone in the skin histology is increased) and the follicular orifice are two principal elements of acne morbidity.The growth of human body sebaceous gland and sebum secretion directly receive the domination of androgen, and adolescence stimulates sebaceous gland because the androgen level significantly improves; Make the sebum secretion dysfunction active, sebum is secreted in a large number, makes skin glossy shinny; Follicular orifice also enlarges thereupon, because the keratinization of pilosebaceous duct or follicular orifice is stopped up, too much sebum can not in time be discharged; The stasis of blood is amassed and in hair follicle, is formed fat bolt, promptly so-called acne.
On remedy of acne, doctor trained in Western medicine mainly is an antibiotic at present, be main with anti-inflammation, but some contains the medicine of tetracycline, takes the burden that medicine can increase the weight of liver, kidney virtually for a long time, and the anemia of pregnant woman is especially had taboo.The medicine for external use of some anti-pox or anti-pox patch all contain A acid composition mostly on the market; But coming off of accelerometer cornu cutaneum matter keeps the drying of skin, thereby treats comedo; But decortication easily after using; And can not touch sunlight, thus avoid using by day, and also anemia of pregnant woman's use also has the danger that causes teratogenesis.Fruit acid series products such as salicylic acid; Also be to be commonly used in treatment comedo, corse sweat pore, aspect such as whiten in recent years; Itself has the regeneration period of quickening cell, and healing and the anti-pox effect of quickening comedo have enjoyed certainly, but the use of this series products can not surpass half a year.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine of treating acne, natural pure, the safety non-toxic of this medicine does not have dependency, is free from side effects.
The method for preparing that this medicine is provided in addition is an another object of the present invention.
Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:
Radix Angelicae Sinensis 8-12 Radix Paeoniae Alba 8-12 Radix Bupleuri 4-8
Poria 8-12 Rhizoma Atractylodis Macrocephalae 8-12 Herba Menthae 1-5
Cortex Moutan 8-12 Fructus Gardeniae 8-12 Radix Scutellariae 10-15
Radix Paeoniae Rubra 1-5 Radix Glycyrrhizae 4-8.
Can said medicine be processed on the pharmaceutics any dosage form such as tablet, pill, powder, capsule, the present invention is oral liquid preferably.
The concrete method for preparing of above-mentioned each component being processed oral liquid according to the invention is:
With above-mentioned medicaments in part by weight mix homogeneously, decocte with water 2～4 times, each 1～2 hour; Collecting decoction filters, and filtrating is condensed into the clear paste of 70 ℃ of relative densities 1.15～1.18; Cold preservation is left standstill, and gets supernatant and filters, and adds conventional adjuvant in the filtrating; Mixing, adding purified water is 1g/ml to containing the crude drug amount, oral liquid formulations is processed in embedding, sterilization.
Method for using: oral, each 1 bag, every bag of 500ml, every day three times.
The traditional Chinese medical science is thought that acne is many and is not relaxed, pathogenic fire derived from stagnation of liver-QI, had a liking for the pungent long-pending heat of cardiopulmonary that causes of food by feelings will.Visceral dysfunction in the body causes the endocrine disturbance, thereby causes that smegma is vigorous due to attacking on showing tremendous enthusiasm, and oils and fats too much stops up pore and forms.The present invention is a good recipe of specially controlling acne, entirely can soothing liver and strengthening spleen and nourish blood.Cortex Moutan among the present invention, Fructus Gardeniae hot and suffocating, as the to rush down three warmers clearing away heat and cooling blood of fighting that looses.Because of all sufferings skin ulcers all belong to " heart ", its China of " heart " main blood is at face, so add can the clear away heart-fire fire of lung of Radix Scutellariae, joins can loose hot and suffocating in the blood of Cortex Moutan Radix Paeoniae Rubra, makes the fire on the inflammation and separates.Radix Scutellariae is joined Fructus Gardeniae discharges the fire on top from urine.As belong to acne cystica and add summer Cordyceps, Thallus Laminariae (Thallus Eckloniae), adding Herba Leonuri like the person of increasing the weight of before the menstruation, constipation with dry stool returns not that passerby strengthens Huang more.。
More than all medicines share, heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, it is high to be used to treat the acne cure rate, no Western medicine prepn is to side effect such as human internal organ infringements, also drug resistance such as antibiotic-free.
For further investigating the clinical efficacy and the safety of medicine of the present invention, select 23 routine patients with acne that the curative effect of medicine of the present invention is carried out clinical observation.
Criterion of therapeutical effect: according to " the clinical research guideline of new Chinese medicine treatment acne " regulation, efficacy determination is main with transference cure, and with reference to change situation such as signs, is divided into healing, produce effects, effective, invalid level Four.Cure: symptom and sign all disappear.Produce effects: symptom and sign are obviously improved.Effectively: symptom and sign have certain improvement.Invalid: symptom and sign all do not have improvement.
Observe patient's logotype ten days through treatment.5 routine patients cure 4 examples, 1 example that takes a turn for the better, total effective rate 80%.Have no side effect and untoward reaction.
The specific embodiment
Embodiment:
Get Radix Angelicae Sinensis 10 kg, the Radix Paeoniae Alba 10 kg, Radix Bupleuri 6 kg, Poria 10 kg, the Rhizoma Atractylodis Macrocephalae 10 kg, Herba Menthae 3 kg, Cortex Moutan 10 kg, Fructus Gardeniae 10 kg, Radix Scutellariae 12 kg, Radix Paeoniae Rubra 3 kg, Radix Glycyrrhizae 6 kg, clean decocte with water 3 times with clear water; Each 1～2 hour, collecting decoction filtered; Filtrating is condensed into the clear paste of 70 ℃ of relative densities 1.15～1.18, and cold preservation is left standstill, and gets supernatant and filters; Add conventional adjuvant in the filtrating; Mixing, adding purified water is 1g/ml to containing the crude drug amount, oral liquid formulations is processed in embedding, sterilization.
Case history one: Yao, the woman, 30 years old, examined 2010 days, and patient's front face half a year occurs little of syringe needle; Like Semen Glycines size erythema, increase gradually greatly, increase the weight of before the menstruation, alleviate after menstruation is clean; In many ways treatment effect is not good, and existing facial red acne are dispersed in blush, squeezes the broken white liquid that flows out.Nervous, before the menstruation mistake, pale tongue with thin fur, stringy and thready pulse.Giving we adds surplus the Herba Leonuri 20 dose.Face acne disappears, and it is calm to leave pigment appearance, continues plus-minus conditioning recovery from illness in two months.
Case history two: Lee, the woman, 25 years old, unmarried, in December, 2010 first visit, the red skin of facial appearance is examined, and the purplish red projection tentacle of color is pressed colour-fast.Big little of the grain of rice like Semen phaseoli radiati, edge clear, menoxenia, several days delegation of defecating, red tongue with thin and yellow fur is dry, stringy and thready pulse.Be diagnosed as facial acne and give we and add surplus the Radix Et Rhizoma Rhei ten dose, and accuse recovery from illness, do not follow up a case by regular visits to recurrence.
Claims (3)
1. treat medicine of acne and preparation method thereof for one kind, it is characterized in that:
Medicine according to the invention is that feedstock production obtains by following parts by weight of traditional Chinese medicines:
Radix Angelicae Sinensis 8-12 Radix Paeoniae Alba 8-12 Radix Bupleuri 4-8
Poria 8-12 Rhizoma Atractylodis Macrocephalae 8-12 Herba Menthae 1-5
Cortex Moutan 8-12 Fructus Gardeniae 8-12 Radix Scutellariae 10-15
Radix Paeoniae Rubra 1-5 Radix Glycyrrhizae 4-8.
2. medicine of treatment acne according to claim 1 and preparation method thereof, its characteristic is being that described medicine is processed oral liquid.
3. the method for preparing of the medicine of the described treatment acne of claim 2 is: with above-mentioned medicaments in part by weight mix homogeneously, and decocte with water 2～4 times, each 1～2 hour; Collecting decoction filters, and filtrating is condensed into the clear paste of 70 ℃ of relative densities 1.15～1.18; Cold preservation is left standstill, and gets supernatant and filters, and adds conventional adjuvant in the filtrating; Mixing, adding purified water is 1g/ml to containing the crude drug amount, oral liquid formulations is processed in embedding, sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102151219A CN102688315A (en) | 2012-06-27 | 2012-06-27 | Medicine for treating acne and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102151219A CN102688315A (en) | 2012-06-27 | 2012-06-27 | Medicine for treating acne and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102688315A true CN102688315A (en) | 2012-09-26 |
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| CN2012102151219A Pending CN102688315A (en) | 2012-06-27 | 2012-06-27 | Medicine for treating acne and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103463570A (en) * | 2013-09-13 | 2013-12-25 | 武万发 | Pharmaceutical composition and preparation method, preparation and application thereof |
| CN104338091A (en) * | 2013-07-23 | 2015-02-11 | 陈学媛 | Drug for treating acne and whelk and preparation method thereof |
| CN104666721A (en) * | 2015-03-30 | 2015-06-03 | 张鹏 | Medicinal composition for treating acne |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593501A (en) * | 2004-07-05 | 2005-03-16 | 天津宏仁堂药业有限公司 | Skin disease treating Chinese traditional medicine |
| CN102406765A (en) * | 2011-12-01 | 2012-04-11 | 荣成市科学技术情报研究所 | Traditional Chinese medicine composition for treating acne |
-
2012
- 2012-06-27 CN CN2012102151219A patent/CN102688315A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593501A (en) * | 2004-07-05 | 2005-03-16 | 天津宏仁堂药业有限公司 | Skin disease treating Chinese traditional medicine |
| CN102406765A (en) * | 2011-12-01 | 2012-04-11 | 荣成市科学技术情报研究所 | Traditional Chinese medicine composition for treating acne |
Non-Patent Citations (2)
| Title |
|---|
| 孙维峰等: "丹栀逍遥散加减治疗月经不调伴面部痤疮36例", 《实用中医内科杂志》 * |
| 陈美华: "丹栀逍遥丸治疗肝气郁结型粉刺60例", 《福建中医药》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104338091A (en) * | 2013-07-23 | 2015-02-11 | 陈学媛 | Drug for treating acne and whelk and preparation method thereof |
| CN103463570A (en) * | 2013-09-13 | 2013-12-25 | 武万发 | Pharmaceutical composition and preparation method, preparation and application thereof |
| CN104666721A (en) * | 2015-03-30 | 2015-06-03 | 张鹏 | Medicinal composition for treating acne |
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Application publication date: 20120926 |