CN102114231B

CN102114231B - Medicine for treating arrhythmia

Info

Publication number: CN102114231B
Application number: CN2011100734196A
Authority: CN
Inventors: 马蓉; 路正平
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-03-25
Filing date: 2011-03-25
Publication date: 2012-07-04
Anticipated expiration: 2031-03-25
Also published as: CN102114231A

Abstract

The invention relates to a medicine for treating arrhythmia, which is made from the following Chinese medicinal materials: Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Paeoniae Alba, Radix Angelicae Sinensis, processed Astragalus membranaceus, Ophiopogon japonicus, Fructus Schisandrae Chinensis, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Semen Ziziphi Spinosae, Semen Platycladi, Radix Curcumae, Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Radix Polygalae, Caulis Perillae, Fructus Aurantii and Radix Glycyrrhizae. Semen Platycladi and Semen Ziziphi Spinosae are moderately parched in a pot and then mixed with the rest eighteen Chinese medicinal materials, the mixture is decocted in water for three times and is filtered, the filtrate is mixed and then dried and pulverized to obtain medicinal active component, and active component is processed to make capsules. The medicine has the effects of nourishing the heart to tranquilize the mind, promoting blood flow to regulate menstruation, strengthening the spleen to replenish qi and tonifying the kidney to calming the heart. The total effectiveness rate for treating arrhythmia reaches 91.6%.

Description

The ARR medicine of a kind of treatment

Technical field

The present invention relates to a kind of medicine, specifically relate to the ARR medicine of a kind of treatment, the invention still further relates to the method for preparing of this medicine.

Background technology

Because the origin that heart is exciting or the rhythm of the heart due to the conduction abnormalities or alteration in heart rate are arrhythmia, this is one of clinical modal cardiovascular performance.The clinical symptoms weight of patients with arrhythmia differs; The lighter can not have any discomfort, and idol comes to light when having a medical check-up, the dynamic electrocardiogram observation that once has the scholar normal person's heart to be carried out 24 hours; Discovery has the normal person about 70% premature beat to occur; But all do not have any clinical symptoms, and clinical manifestation such as severe patient has dizziness, amaurosis, faints, blood pressure drops jeopardizes patient's life.

Arrhythmia belongs to the cardiopalmus category of the traditional Chinese medical science.Cardiopalmus is meant the conscious palpitation of patient, a kind of symptom uneasy even can not be autonomous of having palpitation.Be similar to the arrhythmia that causes owing to heart failure, rheumatic heart disease, viral myocarditis etc. in the modern medicine.

The main cause that causes cardiopalmus be blood vessels operations obstacle and the thinking of feelings will unusually.Theory of Chinese medical science is thought, heart governing blood and vessels, the normal rhythm of the heart and blood circulation; The relative equilibrium that must rely on the heart-yin heart-yang is kept, if just the heart-yin heart-yang can not keep its relative equilibrium to fall ill, cardiopathia then blood can not normally run on sering; The time and have a rest and end, end that the back is multiple to be come; Blood failing to tonify the heart, the uneasiness of then palpitating from nervousness; Insufficiency of blood is then breathed hard in lung; It is then weak to be not enough to body.

The drug development that the treatment arrhythmia is new at present is less; Common drug causes side reaction easily to the relatively poor crowd of Drug tolerance; Though non-medicine can solve the treatment of a part of patients with arrhythmia; But most of patients with arrhythmia still need heal with medicine, and will accomplish safety so make when healing with medicine arrhythmia as far as possible, effectively.

Summary of the invention

The purpose of this invention is to provide and a kind ofly can effect a radical cure arrhythmia, the medicine that has no side effect.

Medicine of the present invention is to be the medicament that crude drug prepares with following parts by weight of traditional Chinese medicines:

Radix Salviae Miltiorrhizae 10-30 Rhizoma Chuanxiongs 10-15

Radix Polygoni Ciliinerve 10-15 Radix Paeoniae Albas 8-20

Radix Angelicae Sinensis 10-30 Radix Astragali Preparatas 10-30

Radix Ophiopogonis 8-20 Fructus Schisandrae Chinensis 8-12

Radix Codonopsis 8-20 Rhizoma Atractylodis Macrocephalaes 8-12

Semen Ziziphi Spinosae 8-20 Semen Platycladi 8-20

Radix Curcumae 8-12 Radix Aucklandiae 8-12

Pericarpium Citri Reticulatae Viride 8-12 Pericarpium Citri Reticulataes 8-12

Radix Polygalae 8-12 Caulis Perillaes 8-12

Fructus Aurantii 8-12 Radix Glycyrrhizaes 2-5.

Further, medicine of the present invention is to be the medicament that crude drug prepares with following parts by weight of traditional Chinese medicines:

Radix Salviae Miltiorrhizae 10-25 Rhizoma Chuanxiongs 10-13

Radix Polygoni Ciliinerve 10-12 Radix Paeoniae Albas 10-20

Radix Angelicae Sinensis 10-20 Radix Astragali Preparatas 10-25

Radix Ophiopogonis 10-20 Fructus Schisandrae Chinensis 10-12

Radix Codonopsis 10-20 Rhizoma Atractylodis Macrocephalaes 10-12

Semen Ziziphi Spinosae 10-20 Semen Platycladi 10-20

Radix Curcumae 10-12 Radix Aucklandiae 10-12

Pericarpium Citri Reticulatae Viride 10-12 Pericarpium Citri Reticulataes 10-12

Radix Polygalae 10-12 Caulis Perillaes 10-12

Fructus Aurantii 10-12 Radix Glycyrrhizaes 3-5.

The method for preparing of medicine of the present invention is following:

A) get Semen Platycladi, go only,, fry, have fragrance to overflow, take out subsequent use to the oil yellow color with little fire heating;

B) get Semen Ziziphi Spinosae and fry to little yellow, take out subsequent use with little fire;

C) 18 herbal medicines of said process of preparing Chinese medicine medicine and all the other being cleaned add 2 times of water and are heated to boiling point with little fire decoction; Decocted 30 minutes, and filtered and obtain medicinal liquid, decoct three times continuously with the method; Merging filtrate; The thick paste that to be condensed into 50 ℃ of relative densities be 1.30-1.38 obtains medicine activity component after the drying and crushing, add starch and process capsule.

Said medicine can also be processed any peroral dosage form on the pharmaceutics, like tablet, pill etc. except that being prepared into capsule.

In this prescription, Radix Salviae Miltiorrhizae promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind; The Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping; Radix Polygoni Ciliinerve is bitter, be slightly cold, and returns Liver Channel, clearing away heat and cooling blood, eliminating stasis to stop pain; Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant; Radix Angelicae Sinensis can be enriched blood, and invigorates blood circulation regulating menstruation, pain relieving, intestine moistening; The invigorating middle warmer of Radix Astragali Preparata QI invigorating; Radix Ophiopogonis YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire; The Fructus Schisandrae Chinensis convergence is astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming; The Radix Codonopsis invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting; Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, the dampness diuretic; Semen Ziziphi Spinosae nourishes heart, and calms the nerves arresting sweating; Semen Platycladi property is put down sweet in the mouth, tranquilizing by nourishing the heart, loosening bowel to relieve constipation; The Radix Curcumae regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice; Radix Aucklandiae acrid in the mouth, hardship, warm in nature; Return spleen, stomach, liver, large intestine channel promoting the circulation of QI to relieve pain, it is soothing the liver to regulate the flow of vital energy, and spleen invigorating disappears stagnant; The soothing the liver dispelling the stagnated QI of Pericarpium Citri Reticulatae Viride, removing food stagnancyization stagnates; The Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, the Fructus Alpiniae Oxyphyllae of calming the nerves is eliminated the phlegm, detumescence; Caulis Perillae, Fructus Aurantii regulating the flow of QI to ease the stomach, pain relieving; The Radix Polygalae Fructus Alpiniae Oxyphyllae of calming the nerves is eliminated the phlegm, detumescence; The Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.All medicines share can tranquilizing by nourishing the heart, promoting blood flow to regulate menstruation, invigorating the spleen and benefiting QI, kidney calming.

For safety and the curative effect that guarantees medicine of the present invention, use medicine capsule of the present invention that the treatment arrhythmia has been carried out observation of curative effect clinically.

80 routine patients with arrhythmia are carried out the random packet comparative study, and selected patient diagnosis standard is (1) shortness of breath and palpitation, and the Mental fatigue spontaneous perspiration is had a dizzy spell, insomnia and dreamful sleep, pale or sallow complexion; (2) palpitation and uneasiness, dysphoria with smothery sensation in the heart, the insomnia dream is many, dizziness and tinnitus, flushed complexion dry pharynx; (3) shortness of breath and palpitation, weak breath is unable, palpitation with a distress feeling, a little less than the low voice breath, more so, painful abdominal mass is vexed in the heart after the fatigue; (4) cardiopalmus is uncomfortable in chest, the time chest pain is arranged, aching as needle stabbing, or to back, upper limb radiating pain;

The patient all does 24 hours electrocardiographic recorders, comprises long II or V 1 record that leads, and through observing P ripple and QRS waveform attitude, P-QRS relation, PP, PR and RR interval, records ARR outbreak.

Therapeutic Method: treatment is organized 48 routine patients and is used capsule of the present invention, three times on the oral one, one time 2, matched group 32 routine patients are with Western medicine propranolol treatment, oral one day sooner or later twice, one time 2, treatment was for 4 weeks the course of treatment.

Efficacy determination: produce effects: the complete conversion of arrhythmia; Improvement: arrhythmia episode number of times and duration of seizure are than reducing more than 50% before treating or treating arrhythmia conversion recidivist in a short time; Invalid: identical or only reduce below 50% before arrhythmia and the medication after the medication.

Therapeutic outcome: treatment group produce effects 28 examples (58.3%), 16 examples that take a turn for the better (33.3%), invalid 4 examples (8.4%), total effective rate is 91.6%; Matched group produce effects 14 examples (43.7%), 12 examples that take a turn for the better (37.5%), invalid 6 examples (18.8%), total effective rate is 81.2%; The result shows that the treatment group obviously is superior to matched group aspect patient's symptom improving, and does not see obvious toxic-side effects.

The specific embodiment

Embodiment 1

Get Radix Salviae Miltiorrhizae 2kg, Rhizoma Chuanxiong 3 kg, Radix Polygoni Ciliinerve 2.5 kg, the Radix Paeoniae Alba 4 kg, Radix Angelicae Sinensis 2kg; Radix Astragali Preparata 4 kg, Radix Ophiopogonis 2 kg, Fructus Schisandrae Chinensis 2 kg, Radix Codonopsis 3 kg, the Rhizoma Atractylodis Macrocephalae 1.8 kg; Semen Ziziphi Spinosae 3 kg, Semen Platycladi 4 kg, Radix Curcumae 2 kg, the Radix Aucklandiae 1.8 kg, Pericarpium Citri Reticulatae Viride 2 kg; Pericarpium Citri Reticulatae 1.6 kg, Radix Polygalae 2 kg, Caulis Perillae 2.4 kg, Fructus Aurantii 2 kg, Radix Glycyrrhizae 1 kg;

A) with Semen Platycladi, go only, with little fire heating, fry to the oil yellow color, there is fragrance to overflow, take out subsequent use;

B) Semen Ziziphi Spinosae is fried to little yellow with little fire, taken out subsequent use;

C) 18 herbal medicines of said process of preparing Chinese medicine medicine and all the other being cleaned add 2 times of water and are heated to boiling point with little fire decoction; Decocted 30 minutes, and filtered and obtain medicinal liquid, decoct three times continuously with the method; Merging filtrate; The thick paste that to be condensed into 50 ℃ of relative densities be 1.30-1.38 obtains medicine activity component after the drying and crushing, add 0.5kg starch and process capsule.

Embodiment 2

Get Radix Salviae Miltiorrhizae 3kg, Rhizoma Chuanxiong 3 kg, Radix Polygoni Ciliinerve 3.5 kg, the Radix Paeoniae Alba 6 kg, Radix Angelicae Sinensis 3kg; Radix Astragali Preparata 7kg, Radix Ophiopogonis 3 kg, Fructus Schisandrae Chinensis 3.5kg, Radix Codonopsis 5 kg, the Rhizoma Atractylodis Macrocephalae 3 kg; Semen Ziziphi Spinosae 6kg, Semen Platycladi 4.5kg, Radix Curcumae 3kg, Radix Aucklandiae 3kg, Pericarpium Citri Reticulatae Viride 3.5 kg; Pericarpium Citri Reticulatae 3kg, Radix Polygalae 3.3 kg, Caulis Perillae 3kg, Fructus Aurantii 3.5 kg, Radix Glycyrrhizae 1.5 kg;

C) 18 herbal medicines of said process of preparing Chinese medicine medicine and all the other being cleaned add 2 times of water and are heated to boiling point with little fire decoction; Decocted 30 minutes, and filtered and obtain medicinal liquid, decoct three times continuously with the method; Merging filtrate; The thick paste that to be condensed into 50 ℃ of relative densities be 1.30-1.38 obtains medicine activity component after the drying and crushing, add 0.8kg starch and process capsule.

Claims

1. treat ARR medicine for one kind, it is characterized in that by following parts by weight of traditional Chinese medicines being that crude drug prepares:

Radix Salviae Miltiorrhizae 10-25 Rhizoma Chuanxiongs 10-13

Radix Polygoni Ciliinerve 10-12 Radix Paeoniae Albas 10-20

Radix Angelicae Sinensis 10-20 Radix Astragali Preparatas 10-25

Radix Ophiopogonis 10-20 Fructus Schisandrae Chinensis 10-12

Radix Codonopsis 10-20 Rhizoma Atractylodis Macrocephalaes 10-12

Semen Ziziphi Spinosae 10-20 Semen Platycladi 10-20

Radix Curcumae 10-12 Radix Aucklandiae 10-12

Pericarpium Citri Reticulatae Viride 10-12 Pericarpium Citri Reticulataes 10-12

Radix Polygalae 10-12 Caulis Perillaes 10-12

Fructus Aurantii 10-12 Radix Glycyrrhizaes 3-5.

2. the method for preparing of the ARR medicine of the said treatment of claim 1 may further comprise the steps:

C) 18 herbal medicines of said process of preparing Chinese medicine medicine and all the other being cleaned add 2 times of water and are heated to boiling point with little fire decoction; Decocted 30 minutes; Filtration obtains medicinal liquid, decocts three times merging filtrate continuously with the method; The thick paste that to be condensed into 50 ℃ of relative densities be 1.30-1.38 obtains the mixed capsule of processing of medicine activity component and starch after the drying and crushing.