CN103479969B

CN103479969B - A kind of medicine for the treatment of manic-depressive psychosis and preparation method thereof

Info

Publication number: CN103479969B
Application number: CN201310446269.8A
Authority: CN
Inventors: 刘建忠
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-09-27
Filing date: 2013-09-27
Publication date: 2015-10-28
Anticipated expiration: 2033-09-27
Also published as: CN103479969A

Abstract

The invention provides a kind of medicine for the treatment of manic-depressive psychosis and preparation method thereof, first by Radix Rehmanniae Preparata 20-40, Rhizoma Acori Graminei 40-60, Semen Sinapis Albae 30-60, Radix Astragali 80-120, Radix Scutellariae 8-12, Radix Paeoniae Alba 15-30, Ramulus Cinnamomi 3-6, Radix Bupleuri 3-6, Poria 15-30, Cortex Moutan 10-20, Poria cum Radix Pini 30-60, Rhizoma Coptidis 3-6, Radix Salviae Miltiorrhizae 10-20, Rhizoma Pinelliae 10-20, pollen 5-15, Gypsum Fibrosum 3-6, Radix Glycyrrhizae 3-6 mix homogeneously, add decocting and filter out decocting liquid 3 times, again by Radix Ginseng 150-250, Margarita 50-150, Radix Notoginseng 40-60, jujube nucleus 400-600, Radix Ophiopogonis 80-120, Radix Angelicae Sinensis 80-120 mix homogeneously, add decocting and filter out decocting liquid 3 times, and merge with first time decocting liquid, finally Radix Ginseng 150-250, Margarita 50-150, Radix Notoginseng 40-60, jujube nucleus 400-600, Cinnabaris 80-120, Olibanum 30-60, Lapis Chloriti 80-120, Alumen 80-120, Lignum Aquilariae Resinatum 100-300, Radix Curcumae 80-120, Semen Platycladi 200-400 mix homogeneously are steeped in the decocting liquid merged, soak into post-drying, pulverizing, add gross weight number 2-3 starch mix homogeneously doubly again, during sterilization incapsulates, make capsule.Duration of efficacy of the present invention is long, evident in efficacy, has no side effect.

Description

A kind of medicine for the treatment of manic-depressive psychosis and preparation method thereof

Technical field

The invention belongs to field of traditional Chinese, be specifically related to a kind of medicine for the treatment of manic-depressive psychosis.The invention still further relates to the preparation method of this medicine.

Background technology

Manic-depressive psychosis is a kind of common clinical, the traditional Chinese medical science thinks manic-depressive psychosis and psychosis, refer to serious mental maladjustment, all can there is lasting obvious exception in the mental activity such as understanding, emotion, will, action behavior of patient, can not learn normally, work, live, action behavior is difficult to be understood by common people, under the domination of morbid psychology, has the action behavior of committing suiside or attacking, injuring other people.

Manic-depressive psychosis be cerebral function incidence rate disorderly, cause the disease of the ergasias such as understanding, emotion, behavior and will obstacle in various degree, cause of disease many-side.Poor for demented medication effect at present, and large to the toxic and side effects of human body, effect is mostly undesirable.

Summary of the invention

The invention solves the deficiencies in the prior art, providing a kind of take Chinese medicine as having no side effect and the medicine of eutherapeutic treatment manic-depressive psychosis of crude drug.

The preparation method of this medicine is provided to be another goal of the invention of the present invention.

Medicine of the present invention is that crude drug prepares by the Chinese medicine of following parts by weight:

Radix Rehmanniae Preparata 20-40 Rhizoma Acori Graminei 40-60 Semen Sinapis Albae 30-60

Radix Astragali 80-120 Radix Scutellariae 8-12 Radix Paeoniae Alba 15-30

Ramulus Cinnamomi 3-6 Radix Bupleuri 3-6 Poria 15-30

Cortex Moutan Poria cum Radix Pini 10-20 30-60 Rhizoma Coptidis 3-6

Radix Salviae Miltiorrhizae 10-20 Rhizoma Pinelliae 10-20 pollen 5-15

Gypsum Fibrosum 3-6 Radix Glycyrrhizae 3-6 Radix Ginseng 300-500

Margarita 100-300 Radix Notoginseng 80-120 jujube nucleus 800-1200

Radix Ophiopogonis 80-120 Radix Angelicae Sinensis 80-120 Cinnabaris 80-120

Olibanum 30-60 Lapis Chloriti 80-120 Alumen 80-120

Lignum Aquilariae Resinatum 100-300 Radix Curcumae 80-120 Semen Platycladi 200-400.

The preferred weight number of described each crude drug is:

Radix Rehmanniae Preparata 30 Rhizoma Acori Graminei 50 Semen Sinapis Albae 50

The Radix Astragali 100 Radix Scutellariae 10 Radix Paeoniae Alba 20

Ramulus Cinnamomi 5 Radix Bupleuri 5 Poria 20

Cortex Moutan 15 Poria cum Radix Pini 50 Rhizoma Coptidis 5

Radix Salviae Miltiorrhizae 15 Rhizoma Pinelliae 15 pollen 10

Gypsum Fibrosum 5 Radix Glycyrrhizae 5 Radix Ginseng 400

Margarita 200 Radix Notoginseng 100 jujube nucleus 1000

Radix Ophiopogonis 100 Radix Angelicae Sinensis 100 Cinnabaris 100

Olibanum 50 Lapis Chloriti 100 Alumen 100

Lignum Aquilariae Resinatum 200 Radix Curcumae 100 Semen Platycladi 300.

The medicine of above-mentioned each component can make pill, powder or capsule.Preferred dosage form of the present invention is capsule.

The concrete preparation method of medicine of the present invention is as follows:

(1) Radix Rehmanniae Preparata, Rhizoma Acori Graminei, Semen Sinapis Albae, the Radix Astragali, Radix Scutellariae, the Radix Paeoniae Alba, Ramulus Cinnamomi, Radix Bupleuri, Poria, Cortex Moutan, Poria cum Radix Pini, Rhizoma Coptidis, Radix Salviae Miltiorrhizae, the Rhizoma Pinelliae, pollen, Gypsum Fibrosum, Radix Glycyrrhizae are pressed above-mentioned parts by weight mix homogeneously, add gross weight number 3-5 decocting doubly to endure, after water boiling, decoct 15-20 minute again, filter out first time decocting liquid; Decoct twice again by above-mentioned steps, filter out decocting liquid, and merge with first time decocting liquid;

(2) by the Radix Ophiopogonis of the Radix Ginseng of above-mentioned parts by weight half, Margarita, Radix Notoginseng, jujube nucleus and above-mentioned parts by weight, Radix Angelicae Sinensis mix homogeneously, decoct according to the method for step (1), filter out decocting liquid, and merge with step (1) decocting liquid;

(3) in the decocting liquid Cinnabaris of remaining for above-mentioned parts by weight Radix Ginseng, Margarita, Radix Notoginseng, jujube nucleus and above-mentioned parts by weight, Olibanum, Lapis Chloriti, Alumen, Lignum Aquilariae Resinatum, Radix Curcumae, Semen Platycladi mix homogeneously bubble merged in step (2), soak after 3-5 hour, dry, be ground into fine powder to sieve, add gross weight number 2-3 starch mix homogeneously doubly, during sterilization incapsulates, make capsule.

In medicament composing prescription of the present invention, Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel, there is yin nourishing of enriching blood, effect of life essence-filling, marrow-benefitting; Rhizoma Acori Graminei: dirtyly to have one's ideas straightened out for warding off, a surname's gas by expectorant, removing toxic substances, parasite killing, controls demented, infantile convulsion, coma due to phlegm syncope, anemofrigid-damp arthralgia, a mouthful fulminant dysentery of keeping silent, external application carbuncle scabies; Semen Sinapis Albae: odorless, acrid in the mouth, peppery, for warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving; Radix Astragali sweet in the mouth, slightly warm in nature, returns liver, spleen, lung, kidney channel, has effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema; Radix Scutellariae: containing abundant active mineral matter, can alleviate the emotion such as nervous, nervousness, hysteria, neurasthenia, depression, sense of crisis often had in busy life effectively; The Radix Paeoniae Alba: cool in nature, bitter in the mouth acid, is slightly cold, has easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving; Ramulus Cinnamomi: pungent, sweet, warm, for warming middle-JIAO, stomach function regulating; Radix Bupleuri: meridian distribution of property and flavor: cold nature, bitter in the mouth, pungent, return Liver Channel, gallbladder meridian, tool depressed liver-energy dispersing and function of gallbladder promoting, dredge gas resolving depression, loose effect of fire; Poria: promoting diuresis to eliminate damp pathogen, invigorating the spleen for dissipating phlegm, mind tranquilizing and the heart calming, relieves internal heat anticancer, has the effect of enhancing immunity, antitumor and calmness, blood sugar lowering etc.; Cortex Moutan: cold in nature, bitter in the mouth, cool, be slightly cold, clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis; Poria cum Radix Pini: sweet, light GUIXIN, spleen channel, mind calming, calm the nerves, diuretic, for palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria; Rhizoma Coptidis: the disease such as, vomiting damp and hot for retention of damp-heat in the interior, the intestines and stomach, dysentery; Radix Salviae Miltiorrhizae: promoting blood circulation to restore menstrual flow, evacuation of pus granulation promoting, have a pain for menoxenia, blood stasis, amenorrhea, lump in the abdomen, coronary heart diseases and angina pectoris, ectopic pregnancy, vexed interior-heat, carbuncle sore tumefacting virus etc.; The Rhizoma Pinelliae: drying dampness to eliminate phlegm, stomach function regulating preventing or arresting vomiting, cures mainly phlegm-damp diseases caused by retention of fluid, vomiting, the diseases such as cough with asthma; Pollen: energy endocrine regulation, maintains ovary normal function; Gypsum Fibrosum: cool in nature, has effect of heat-clearing and toxic substances removing; Radix Glycyrrhizae: energy heat-clearing and toxic substances removing, nourishing the lung to arrest cough, coordinating the actions of various ingredients in a prescription, Radix Glycyrrhizae Preparata energy invigorating the spleen and replenishing QI; Radix Ginseng: property is flat, sweet in the mouth, micro-hardship, tepor, returns spleen, lung meridian, heart channel.Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, Fructus Alpiniae Oxyphyllae of calming the nerves; Margarita: there is the effects such as arresting convulsion of calming the nerves, improving eyesight removing nebula, removing toxic substances and promoting granulation, modern study also shows that Margarita is improving the effect all in body immunity, slow down aging, freckle removing and whitening, supplement calcium etc. with uniqueness; Radix Notoginseng: cure mainly to fall and flutter congestive edema, thoracic obstruction angor, lump in the abdomen, blood stasis amenorrhea, dysmenorrhea, the cloudy stomachache of the stasis of blood in puerperal, sore, carbuncle and painful swelling; Jujube nucleus: nourishing the liver, mind calming, calms the nerves, arresting sweating; Cinnabaris: conventional settling tranquilizer; Olibanum: regulating qi and activating blood, analgesic therapy, chases after poison, controls coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge; Lapis Chloriti: sweet, salty, flat.The pendant expectorant therapeutic method to keep the adverse QI flowing downwards, checking hyperfunction of the liver for relieving convulsion, controls pertinacious phlegm cementing, cough with dyspnea dyspnea with rapid respiration, and epilepsy is gone mad, irritated uncomfortable in chest, convulsion with spasms; Alumen: for expectorant, dampness, antidiarrheal, hemostasis, removing toxic substances, parasite killing, controls epilepsy, sore throat, and remorse saliva is stopped up very, hepatitis, jaundice, general edema with yellowish skin, taste-blindness rate, uterine prolapse, leucorrhea, dysentery, epistaxis, aphtha of the mouth and tongue, skin ulcer hemorrhoid scabies, water, fire, insect bite; Irritability, falls in Lignum Aquilariae Resinatum: treating the liver is strongly fragrant, and taste, and disappear dampness, and diuretic is had one's ideas straightened out; Radix Curcumae: promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs; Semen Platycladi: the saturating heart of fragrance, body profit grows blood, same to Poria cum Radix Pini, Semen Ziziphi Spinosae, the Radix Rehmanniae, Radix Ophiopogonis, and be product clear in turbid, cure mainly mind void timid, palpitation with fear severe palpitation, color is wan and sallow, skin pruritus due to dryness.

It is collaborative that the present invention adopts multiple medical material to combine, and is mainly used in heat-clearing and toxic substances removing, cooling blood and dissolving stasis, removing heat from the lung and dissipating phlegm, promoting diuresis to eliminate damp pathogen, the removing heat from blood that clears away heart-fire, nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization, has significant therapeutic effect to demented.

For investigating the clinical efficacy of Drug therapy manic-depressive psychosis of the present invention further, 100 routine manic-depressive psychosis patients are selected to carry out clinical observation on the therapeutic effect.

Select outpatient 100 example, wherein man 35 example, female 65 example, at 30 ~ 65 years old age, the course of disease is the shortest 2 months, the longest 5 years.

Diagnostic criteria

1. there is demented family history, or cerebral trauma history.Generally introverted, the unsuccessful or prominent round accident of recent in love will, terrified and in a disturbed state of mind person;

2. depressed emotions, apathetic expression, quiet and few dynamic, being reticent and dementia, or soliloquy, speaking incoherently; Or bolt suddenly, stir up a disturbance not peaceful, catchword is cursed and beaten, and does not keep away close and distant;

3. get rid of caused by medicine, poisoning, calentura reason;

4. head CT, AMI and the no positive discovery of other auxiliary examination.

Therapeutic Method

Oral medicine of the present invention, three times on the one, a 4-6 grain.

Criterion of therapeutical effect

Cure: symptom all disappears; Main Physico-chemical tests index is normally, and symptom is without recurrence;

Effective: symptomatology is eliminated or cardinal symptom is eliminated; Physico-chemical tests index is normal, has slight recurrence status after 1 month;

Effective: cardinal symptom disappears substantially; Be interrupted outbreak, orthobiosis is affected, and main Physico-chemical tests index makes moderate progress;

Invalid: main Physico-chemical tests index is front unchanged with treatment, demented recurrent exerbation.

Therapeutic outcome

5 courses for the treatment of of 100 routine patient's oral administration Drug therapy of the present invention, cure 86 people, cure rate 86%, effective 5 people, effective percentage 91%, invalid 9 people.

Duration of efficacy of the present invention is long, evident in efficacy, has no side effect, and is conducive to sufferer and alleviates condition of illness in time.

Detailed description of the invention

Embodiment 1

(1) removing impurity, the Radix Rehmanniae Preparata 20g cleaned up, Rhizoma Acori Graminei 40g, Semen Sinapis Albae 30g, Radix Astragali 80g, Radix Scutellariae 8g, Radix Paeoniae Alba 15g, Ramulus Cinnamomi 3g, Radix Bupleuri 3g, Poria 15g, Cortex Moutan 10g, Poria cum Radix Pini 30g, Rhizoma Coptidis 3g, Radix Salviae Miltiorrhizae 10g, Rhizoma Pinelliae 10g, pollen 5g, Gypsum Fibrosum 3g, Radix Glycyrrhizae 3g is got by above-mentioned parts by weight mix homogeneously, the decocting adding gross weight number 3 times is endured, after water boiling, decoct 15 minutes again, filter out first time decocting liquid; Decoct twice again by above-mentioned steps, filter out decocting liquid, and merge with first time decocting liquid;

(2) get removing impurity, the Radix Ginseng 150g cleaned up, Margarita 50g, Radix Notoginseng 40g, jujube nucleus 400g, Radix Ophiopogonis 80g, Radix Angelicae Sinensis 80g mix homogeneously, decoct according to the method for step (1), filter out decocting liquid, and merge with step (1) decocting liquid;

(3) removing impurity is got, in decocting liquid that the Radix Ginseng 150g cleaned up, Margarita 50g, Radix Notoginseng 40g, jujube nucleus 400g, Cinnabaris 80g, Olibanum 30g, Lapis Chloriti 80g, Alumen 80g, Lignum Aquilariae Resinatum 100g, Radix Curcumae 80g, Semen Platycladi 200g mix homogeneously bubble merge in step (2), soak after 3-5 hour, dry, be ground into fine powder to sieve, add the starch mix homogeneously of gross weight number 2 times, during sterilization incapsulates, make capsule.

Using method: take medicine of the present invention, three times on the one, a 4-6 grain.

Embodiment 2

(1) removing impurity, the Radix Rehmanniae Preparata 30g cleaned up, Rhizoma Acori Graminei 50g, Semen Sinapis Albae 50g, Radix Astragali 100g, Radix Scutellariae 10g, Radix Paeoniae Alba 20g, Ramulus Cinnamomi 5g, Radix Bupleuri 5g, Poria 20g, Cortex Moutan 15g, Poria cum Radix Pini 50g, Rhizoma Coptidis 5g, Radix Salviae Miltiorrhizae 15g, Rhizoma Pinelliae 15g, pollen 10g, Gypsum Fibrosum 5g, Radix Glycyrrhizae 5g is got by above-mentioned parts by weight mix homogeneously, the decocting adding gross weight number 3 times is endured, after water boiling, decoct 15 minutes again, filter out first time decocting liquid; Decoct twice again by above-mentioned steps, filter out decocting liquid, and merge with first time decocting liquid;

(2) get removing impurity, the Radix Ginseng 200g cleaned up, Margarita 100g, Radix Notoginseng 50g, jujube nucleus 500g, Radix Ophiopogonis 100g, Radix Angelicae Sinensis 100g mix homogeneously, decoct according to the method for step (1), filter out decocting liquid, and merge with step (1) decocting liquid;

(3) removing impurity is got, in decocting liquid that the Radix Ginseng 200g cleaned up, Margarita 100g, Radix Notoginseng 50g, jujube nucleus 500g, Cinnabaris 100g, Olibanum 50g, Lapis Chloriti 100g, Alumen 100g, Lignum Aquilariae Resinatum 200g, Radix Curcumae 100g, Semen Platycladi 300g mix homogeneously bubble merge in step (2), soak after 3-5 hour, dry, be ground into fine powder to sieve, add the starch mix homogeneously of gross weight number 2.5 times, during sterilization incapsulates, make capsule.

Embodiment 3

(1) removing impurity, the Radix Rehmanniae Preparata 40g cleaned up, Rhizoma Acori Graminei 60g, Semen Sinapis Albae 60g, Radix Astragali 120g, Radix Scutellariae 12g, Radix Paeoniae Alba 30g, Ramulus Cinnamomi 6g, Radix Bupleuri 6g, Poria 30g, Cortex Moutan 20g, Poria cum Radix Pini 60g, Rhizoma Coptidis 6g, Radix Salviae Miltiorrhizae 20g, Rhizoma Pinelliae 20g, pollen 15g, Gypsum Fibrosum 6g, Radix Glycyrrhizae 6g is got by above-mentioned parts by weight mix homogeneously, the decocting adding gross weight number 3 times is endured, after water boiling, decoct 15 minutes again, filter out first time decocting liquid; Decoct twice again by above-mentioned steps, filter out decocting liquid, and merge with first time decocting liquid;

(2) get removing impurity, the Radix Ginseng 250g cleaned up, Margarita 150g, Radix Notoginseng 60g, jujube nucleus 600g, Radix Ophiopogonis 120g, Radix Angelicae Sinensis 120g mix homogeneously, decoct according to the method for step (1), filter out decocting liquid, and merge with step (1) decocting liquid;

(3) removing impurity is got, in decocting liquid that the Radix Ginseng 250g cleaned up, Margarita 150g, Radix Notoginseng 60g, jujube nucleus 600g, Cinnabaris 120g, Olibanum 60g, Lapis Chloriti 120g, Alumen 120g, Lignum Aquilariae Resinatum 300g, Radix Curcumae 120g, Semen Platycladi 400g mix homogeneously bubble merge in step (2), soak after 3-5 hour, dry, be ground into fine powder to sieve, add the starch mix homogeneously of gross weight number 3 times, during sterilization incapsulates, make capsule.

Claims

1. treating a medicine for manic-depressive psychosis, is be that crude drug prepares by the Chinese medicine of following parts by weight: