CN105687489A - Drug for treating atopic dermatitis and preparation method and application thereof - Google Patents

Abstract

The invention discloses a pharmaceutical composition for treating dermatitis, which is a preparation prepared from raw materials in the following weight proportions: 10-15 parts of buffalo horn, 10-15 parts of rehmannia glutinosa, 10-15 parts of Caulis Spatholobus, 10-15 parts of Danshen, 10-15 parts of Tribulus terrestris, 5-10 parts of black snake, 10-15 parts of silkworm, 10-15 parts of cicada slough, 10-15 parts of Digupi, 15-20 parts of Morus alba, 15-20 parts of white fresh skin, 15-20 parts of Bauhinia bark, 10-15 parts of Shouwu vine, 10-15 parts of astragalus, 10-15 parts of atractylodes rhizome, 10-15 parts of Atractylodes macrocephala, 6-10 parts of roasted licorice. The pharmaceutical composition of the invention has precise compatibility, and the flavors of the medicines complement each other, and has remarkable curative effect on the atopic dermatitis, and provides a new choice for clinical treatment.

Description

A kind of medicine for treating atopic dermatitis and its preparation method and application

technical field

The invention relates to a medicine for treating atopic dermatitis, a preparation method and application thereof.

Background technique

Atopic dermatitis (AD), also known as atopic dermatitis or atopic dermatitis, is a chronic, inflammatory, immune dysfunction skin disease with severe itching as the main clinical feature. A common chronic relapsing skin disorder. It usually starts in infancy, and the clinical manifestations in different periods are not completely the same, but it is mainly characterized by long-term recurrent itching and eczema-like skin lesions, which seriously affects the physical and mental health and quality of life of patients. Atopic dermatitis in children is a common disease in children. 5–20% of children in the world suffer from atopic dermatitis. The incidence is higher in developed countries such as Japan, Europe and the United States, and more than 20% of children in the United States are affected. With the increase in industrialization and environmental pollution, the incidence rate is increasing.

The pathogenesis of this disease is still unclear, and the immunological mechanism of the disease is very complex. Immune-mediated inflammation involves Langerhans cells or dendritic cells presenting allergens, Th1/Th2 imbalance and regulatory cell dysfunction, Eosinophils and specificity participate in and expand the inflammatory response, keratinocytes produce cytokines and inflammatory mediators participate in the inflammatory response and other links. Most AD patients have dysregulation of T cell differentiation and abnormal expression of various inflammation-related factors or neurotransmitters. AD is considered to be a classic Th1/Th2 imbalanced skin disease.

Western medicine uses local application of glucocorticoids, calcineurin inhibitors, antihistamines, immunosuppressants, immunomodulators, etc., or physical therapy such as phototherapy, but they all have different side effects and are not suitable for long-term treatment. Use, prone to relapse after drug withdrawal. Traditional Chinese medicine treatment can significantly relieve pruritus and skin lesions, and can also effectively reduce the number of recurrences, prolong the remission period, improve the quality of life, and the patient's acceptance is good. In this regard, traditional Chinese medicine treatment of this disease has unique advantages and good prospects for clinical application.

Contents of the invention

The object of the present invention is to provide a new traditional Chinese medicine composition for treating atopic dermatitis, its preparation method and application.

A pharmaceutical composition for the treatment of dermatitis, which is a preparation prepared from the bulk drug in the following weight ratio:

10-15 parts of buffalo horn, 10-15 parts of rehmannia root, 10-15 parts of Millae Spatholobus, 10-15 parts of Salvia miltiorrhiza, 10-15 parts of Tribulus terrestris, 5-10 parts of black snake, 10-15 parts of silkworm, cicada slough 10-15 parts, Digupi 10-15 parts, Morus alba 15-20 parts, Baixian 15-20 parts, Bauhinia bark 15-20 parts, Shouwu vine 10-15 parts, Astragalus 10-15 parts, 10-15 parts of Atractylodes Rhizome, 10-15 parts of Atractylodes Rhizome, 6-10 parts of Zhi Licorice.

Preferably, it is a preparation prepared from raw materials in the following weight ratio:

10 parts of buffalo horn, 10 parts of rehmannia root, 10 parts of Miltifolia, 10 parts of Salvia miltiorrhiza, 10 parts of Tribulus terrestris, 5 parts of black snake, 10 parts of silkworm, 10 parts of cicada slough, 10 parts of Digupi, 15 parts of Morus alba , 15 parts of white fresh skin, 15 parts of Bauhinia skin, 10 parts of Shouwu vine, 10 parts of astragalus, 10 parts of atractylodes rhizome, 10 parts of Atractylodes macrocephala, and 6 parts of roasted licorice.

Wherein, the rehmannia glutinosa is raw rehmannia glutinosa.

Wherein, the pharmaceutical composition is a preparation prepared from the drug powder of the raw drug or its water or machine solvent extract as the active ingredient, plus pharmaceutically acceptable adjuvants or auxiliary ingredients.

Preferably, the formulation is an oral formulation. Further preferably, the oral preparation is decoction, powder, tablet or capsule.

The present invention also provides a preparation method of the aforementioned pharmaceutical composition, which is characterized in that it comprises the following steps:

(1) Take raw and auxiliary materials by weight ratio;

(2) The decoction liquid is obtained by adding pharmaceutically acceptable auxiliary materials or auxiliary ingredients.

The present invention also provides the application of the aforementioned pharmaceutical composition in the preparation of medicine for treating dermatitis.

Wherein, the medicine for treating dermatitis is a medicine for treating atopic dermatitis. Wherein, the medicine is a medicine for treating blood deficiency and wind-dryness type atopic dermatitis.

The pharmaceutical composition of the present invention has precise compatibility, and the flavors of the medicines complement each other, and has remarkable curative effect on relieving the condition of patients with atopic dermatitis and preventing recurrence, can treat the atopic dermatitis more effectively, and provides a new choice for clinical medication.

Apparently, according to the above content of the present invention, according to common technical knowledge and conventional means in this field, without departing from the above basic technical idea of the present invention, other various forms of modification, replacement or change can also be made.

The above-mentioned content of the present invention will be further described in detail below through specific implementation in the form of examples. However, this should not be construed as limiting the scope of the above-mentioned subject matter of the present invention to the following examples. All technologies realized based on the above contents of the present invention belong to the scope of the present invention.

detailed description

Preparation and use of embodiment 1 pharmaceutical composition of the present invention

Prescription: 10g of buffalo horn, 10g of rehmannia root, 10g of Caulis Spatholobus, 10g of Salvia miltiorrhiza, 10g of Tribulus terrestris, 5g of black snake, 10g of silkworm, 10g of cicada slough, 10g of digupi, 15g of mulberry bark, 15g of white fresh bark, Bauhinia Skin 15g, Shouwu vine 10g, Astragalus 10g, Atractylodes 10g, Atractylodes macrocephala 10g, Zhigancao 6g.

Preparation method: 1 dose per day, decocted in water 3 times, and take 300mL of juice.

How to use: Take it in 3 times in the morning, noon and evening, for 4 consecutive weeks, and adjust the dose according to the age of the child.

The beneficial effects of the present invention will be specifically described below through test examples.

Embodiment 2 Preparation and use of the pharmaceutical composition of the present invention

Prescription: 15g of buffalo horn, 15g of rehmannia root, 15g of Caulis Spatholobus, 15g of Salvia miltiorrhiza, 15g of Tribulus terrestris, 10g of black snake, 15g of silkworm, 15g of cicada slough, 15g of digupi, 20g of mulberry bark, 20g of white fresh bark, Bauhinia Skin 20g, Shouwu vine 15g, Astragalus 15g, Atractylodes 15g, Atractylodes macrocephala 15g, Zhigancao 10g.

Preparation method: 1 dose per day, decocted in water 3 times, and take 300mL of juice.

How to use: Take it in 3 times in the morning, noon and evening, for 4 consecutive weeks, and adjust the dose according to the age of the child.

The beneficial effects of the present invention will be specifically described below through test examples.

Embodiment 3 Preparation and use of the pharmaceutical composition of the present invention

Prescription: 12g of buffalo horn, 12g of rehmannia root, 12g of Caulis Spatholobus, 12g of Salvia miltiorrhiza, 12g of Tribulus terrestris, 7g of black snake, 12g of silkworm, 12g of cicada slough, 12g of digupi, 17g of mulberry bark, 17g of white fresh bark, Bauhinia Skin 17g, Shouwu vine 12g, Astragalus 12g, Atractylodes 12g, Atractylodes macrocephala 12g, Zhigancao 8g.

Preparation method: 1 dose per day, decocted in water 3 times, and take 300mL of juice.

How to use: Take it in 3 times in the morning, noon and evening, for 4 consecutive weeks, and adjust the dose according to the age of the child.

The beneficial effects of the present invention will be specifically described below through test examples.

The beneficial effect of the present invention is illustrated below in the mode of experimental example:

Test example 1 clinical case statistics

(1) Criteria for admitted patients (or diagnostic criteria)

Gender and age range of patients: 120 patients, aged 2 to 14 years old, 50 females, 70 males, the shortest duration of the disease is half a year, the longest is 3 years, the shortest treatment time is 2 months, and the longest is half a year.

Diagnostic criteria:

Williams diagnostic criteria for atopic dermatitis:

(1) Main criteria: pruritus.

(2) Minor criteria:

① A history of dermatitis and eczema on the flexor side, including the cubital fossa, popliteal fossa, anterior ankle, and neck (children under 10 years old include cheek rash);

②A history of asthma or allergic rhinitis (or a history of atopic diseases in first-degree relatives of children under 4 years old);

③History of dry skin all over the body in recent years;

④ There is flexural eczema (eczema on the cheeks/forehead and extensor limbs of children under 4 years old);

⑤ Onset before 2 years old (applicable to patients over 4 years old).

(3) Determine the standard: main standard + 3 or more secondary standards.

Symptom characteristics of traditional Chinese medicine (or western medicine): it often occurs on the face, mostly starting from the cheeks, the skin lesions have various shapes, most of them are symmetrically distributed, severe itching, tending to exudate, recurrent attacks, and easy to become chronic.

Diagnosis: Atopic Dermatitis

(2) Standard of treatment

The severity of the disease was assessed by the SCORAD method. Those with a score of less than 24 were considered mild, those with a score of 25-50 were considered moderate, and those with a score of 51-103 were considered poisoned.

Basic cure: the skin lesions completely subsided, the pruritus symptoms completely disappeared, and the AD score decreased by more than 90%;

Significantly effective: the skin lesions subsided significantly, the symptoms of itching were significantly relieved, and the AD score was reduced by 60%-90%;

Effective: skin lesions partially subside, pruritus symptoms are obvious, and AD score is reduced by 20%-60%;

Ineffective: no significant change in skin lesions, no improvement or even aggravation of pruritus symptoms, AD score decreased by less than 20% or increased.

(3) Treatment methods

1. Administration method: After the diagnosis was confirmed, 120 patients were given the following medicines: 10g of buffalo horn, 10g of rehmannia root, 10g of Caulis Spatholobus, 10g of Salvia miltiorrhiza, 10g of Tribulus terrestris, 5g of black snake, 10g of silkworm, 10g of cicada slough, 10g Digupi, 15g Morus alba, 15g Baixian, 15g Bauhinia, 10g Shouwu vine, 10g Astragalus, 10g Atractylodes atractylodes, 10g Atractylodes macrocephala, 6g roasted licorice.

Take 1 dose per day, decoct 3 times in water, and take 300mL of juice. Take 3 times in the morning, noon and evening, for 4 consecutive weeks, and adjust the dose according to the age of the child. During the treatment period, no other western medicine and other treatments are provided.

During the treatment period, the diet should be light, avoid fat, sweet and thick flavors, avoid sweets, seafood and hot fruits, and advise to eat more vegetables.

2. Those with no obvious drug contraindications and sensitive skin.

(4) Treatment results

Duration of treatment: 12 weeks

Efficacy judgment: the results are as follows

The curative effect of 1120 patients in table 12 weeks after treatment

treatment result Number of cases (cases) Efficient(%) get well 29 24.16 markedly effective 19 15.83 efficient 56 46.66 invalid 16 13.33 total 120 86.66

It can be seen from Table 1 that the curative effect of the pharmaceutical composition of the present invention is excellent, and the total effective rate is as high as 86.66%.

Adverse reactions: No adverse reactions were seen during the medication period. Occasionally, some patients had slight diarrhea in the later stage of treatment, which was relieved and controlled after adjusting the dosage. Some patients had no abnormality in blood examination, liver and kidney function.

In the prescription, buffalo horn, rehmannia glutinosa, salvia miltiorrhiza and Caulis Spatholobus enter the blood system, nourish blood and cool blood, promote blood circulation and remove stasis, embodying the meaning of "treating wind first, treating blood, and blood moving wind to extinguish itself"; black snake, tribulus terrestris, stiff Silkworms and cicadas slough off the wind and relieve itching, designed for "no wind, no itching"; Digupi, Morus alba, Baixianpi, and Bauhinia skin "treat the skin with the skin" introduce various medicines to the skin, and also have the effect of clearing away heat and relieving itching Itching skills; Shouwu vine nourishes the heart and relieves the air, drives the wind and connect; combined with the characteristics of the characteristics of the disease and the lack of spleen of the children, so the astragalus, atractylodes, and the qi qi and the spleen are used to remove the spleen. spleen and stomach. The combination of various medicines nourishes blood and dispels wind, moistens dryness and relieves itching, strengthens the spleen and dispels dampness, takes both symptoms and symptoms into consideration, treats syndromes and symptoms together, and treats children with atopic dermatitis caused by blood deficiency and wind-dryness.

(5) Typical cases

Patient Liu, female, 8 years old. The patient developed red pimples on the arm since childhood, which can be temporarily relieved after taking Claritan, but it is easy to relapse, especially in late summer and early autumn, and repeated external use of glucocorticoids has no obvious effect. Recently, the patient had recurring pimples on the arms and severe itching. Immediate diagnosis: dark red pimples were seen on the arms and back of the hands, with little exudate, and some pigmentation was seen. Pulse stringy. It was diagnosed as blood deficiency and wind dryness type. It is suitable for nourishing blood and expelling wind. Use the method of the present invention, and suggest that the patient's diet is light, avoid fat, sweet and thick taste, avoid sweets, seafood and hot fruits. According to the above treatment for 1 course of treatment, the color of skin lesions became lighter and the skin lesions decreased; after another 1 course of treatment, the color of skin lesions became normal skin color.

The above experiments show that the pharmaceutical composition of the present invention has a significant curative effect on alleviating the condition of patients with atopic dermatitis.

Claims (10)

1. the pharmaceutical composition treating dermatitis, it is characterised in that: it is prepared by the preparation that the crude drug of weight proportion is prepared from:

Cornu Bubali 10-15 part, Radix Rehmanniae 10-15 part, Caulis Spatholobi 10-15 part, Radix Salviae Miltiorrhizae 10-15 part, Fructus Tribuli 10-15 part, Zaocys 5-10 part, Bombyx Batryticatus 10-15 part, Periostracum Cicadae 10-15 part, Cortex Lycii 10-15 part, Cortex Mori 15-20 part, Cortex Dictamni 15-20 part, Cortex cercis chinensis 15-20 part, Caulis Polygoni Multiflori 10-15 part, Radix Astragali 10-15 part, Rhizoma Atractylodis 10-15 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Radix Glycyrrhizae Preparata 6-10 part。

2. pharmaceutical composition according to claim 1, it is characterised in that: it is prepared by the preparation that the crude drug of weight proportion is prepared from:

Cornu Bubali 10 parts, Radix Rehmanniae 10 parts, Caulis Spatholobi 10 parts, Radix Salviae Miltiorrhizae 10 parts, Fructus Tribuli 10 parts, Zaocys 5 parts, Bombyx Batryticatus 10 parts, Periostracum Cicadae 10 parts, Cortex Lycii 10 parts, Cortex Mori 15 parts, Cortex Dictamni 15 parts, Cortex cercis chinensis 15 parts, Caulis Polygoni Multiflori 10 parts, the Radix Astragali 10 parts, Rhizoma Atractylodis 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Radix Glycyrrhizae Preparata 6 parts。

3. pharmaceutical composition according to claim 1 and 2, it is characterised in that: described Radix Rehmanniae is Radix Rehmanniae。

4. the pharmaceutical composition according to claims 1 to 3 any one, it is characterized in that: it is the medicated powder by described crude drug or its water or machine solvent extractable matter is effective ingredient, adds the preparation that pharmaceutically acceptable adjuvant or complementary composition are prepared from。

5. pharmaceutical composition according to claim 4, it is characterised in that: described preparation is oral formulations。

6. pharmaceutical composition according to claim 5, it is characterised in that: described oral formulations is decoction, powder, tablet or capsule。

7. prepare the preparation method of pharmaceutical composition described in claim 1～6 any one for one kind, it is characterised in that: it includes following operating procedure:

(1) supplementary material is weighed by weight ratio；

(2) decoction liquor, adds pharmaceutically acceptable adjuvant or complementary composition, to obtain final product。

8. the purposes in the medicine of preparation treatment dermatitis of the pharmaceutical composition described in claim 1～6 any one。

9. purposes according to claim 8, it is characterised in that: described medicine is the medicine for the treatment of atopic dermatitis。

10. purposes according to claim 9, it is characterised in that: described medicine is the medicine for the treatment of blood-deficiency and wind-dry type atopic dermatitis。