CN110201075A - A kind of pharmaceutical composition for treating chalazion - Google Patents
A kind of pharmaceutical composition for treating chalazion Download PDFInfo
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- CN110201075A CN110201075A CN201910545337.3A CN201910545337A CN110201075A CN 110201075 A CN110201075 A CN 110201075A CN 201910545337 A CN201910545337 A CN 201910545337A CN 110201075 A CN110201075 A CN 110201075A
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- chalazion
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- 241001608562 Chalazion Species 0.000 title claims abstract description 31
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 25
- 239000003814 drug Substances 0.000 claims abstract description 22
- 206010062717 Increased upper airway secretion Diseases 0.000 claims abstract description 13
- 208000026435 phlegm Diseases 0.000 claims abstract description 13
- 210000000941 bile Anatomy 0.000 claims abstract description 12
- 244000144730 Amygdalus persica Species 0.000 claims abstract description 11
- 240000004980 Rheum officinale Species 0.000 claims abstract description 11
- 241000489492 Arisaema Species 0.000 claims abstract description 10
- 235000001287 Guettarda speciosa Nutrition 0.000 claims abstract description 10
- 235000006040 Prunus persica var persica Nutrition 0.000 claims abstract description 10
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 9
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 9
- 241000601164 Clematis orientalis Species 0.000 claims abstract description 9
- 244000183914 Dianthus superbus Species 0.000 claims abstract description 9
- 235000008081 Rheum officinale Nutrition 0.000 claims abstract description 9
- 229940116229 borneol Drugs 0.000 claims abstract description 9
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 9
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000013535 Dianthus superbus Nutrition 0.000 claims abstract description 8
- 240000002045 Guettarda speciosa Species 0.000 claims abstract 2
- 230000000694 effects Effects 0.000 claims description 19
- 239000008280 blood Substances 0.000 claims description 11
- 210000004369 blood Anatomy 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 9
- 230000001737 promoting effect Effects 0.000 claims description 7
- 206010007247 Carbuncle Diseases 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000003889 eye drop Substances 0.000 claims description 5
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- 239000003885 eye ointment Substances 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 239000003053 toxin Substances 0.000 claims description 5
- 231100000765 toxin Toxicity 0.000 claims description 5
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- 239000002674 ointment Substances 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 abstract description 13
- 241000501113 Sargentodoxa cuneata Species 0.000 abstract description 9
- 238000000034 method Methods 0.000 abstract description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
- 201000010099 disease Diseases 0.000 abstract description 4
- 244000061520 Angelica archangelica Species 0.000 description 8
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
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- 241000207834 Oleaceae Species 0.000 description 1
- 241000590428 Panacea Species 0.000 description 1
- 241001522129 Pinellia Species 0.000 description 1
- 244000197580 Poria cocos Species 0.000 description 1
- 235000008599 Poria cocos Nutrition 0.000 description 1
- 235000015533 Prunus davidiana Nutrition 0.000 description 1
- 240000002381 Prunus davidiana Species 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 241000219061 Rheum Species 0.000 description 1
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- 229940010454 licorice Drugs 0.000 description 1
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- 229940126532 prescription medicine Drugs 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
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Abstract
The present invention relates to field of medicaments, a kind of pharmaceutical composition for treating chalazion is provided, we are made of peach kernel 30-120g, radices trichosanthis 10-30g, sargentodoxa cuneata 10-20g, root of Chinese clematis 10-50g, arisaema cum bile 10-50g, root of Dahurain angelica 10-30g, dianthus superbus 10-30g, rheum officinale 10-30g, Fructus Forsythiae 10-30g, borneol 2-5g.Chalazion is ophthalmology common disease, generally requires operation excision.Chinese medicine thinks that its interpretation of the cause, onset and process of an illness is phlegm stagnation in collateral, can treat chalazion using pharmaceutical composition and its preparation of the invention, mass is made slowly to dissipate, and woth no need to operative treatment, effective percentage is adapted to all groups up to 95% or more.
Description
Technical field
The present invention relates to field of medicaments, a kind of pharmaceutical composition for treating chalazion is provided and its for treating chalazion
Application.
Background technique
Chalazion is also known as chalazion, be children and at per capita can illness, belong to Chinese medicine chalazion.Also known as " wart
Disease ", " chalazion ", refer to stiff core in born of the same parents' eyelid, touching not bitterly, color of the leather eye disease as usual.In paediatrics illness more and more often
See.
The induced factor of this disease is mainly because of the mixed knot of the dysfunction of the spleen in transport, phlegm wet cohesion, upper resistance born of the same parents' eyelid train of thought and qi and blood；It is thick to throw off restraint food
Taste, taste accumulate long-pending damp and hot, damp phlegm of burning life, mix qi and blood and phlegm heat and tie into sick；Motherland's medicine claims " chalazion "；It is Meibomian gland
Outlet obstruction, Meibomian gland chronic inflammatory granuloma caused by ischesis；The course of disease is slow, and eyelid surface skin protuberance is accessible
Scleroma, mostly occurs in upper eyelid, can also upper and lower eyelid it is concurrent, individually also can be multiple while or can successively occur；Overturn eyelid, it is seen that
Affected part conjunctiva takes on a red color, purple；Operative treatment is now mostly used, but mostly easy to recur after treatment, treatment price is higher, increases patient
Pain.
Prior art CN105434739A provides a kind of Chinese medicine composition and preparation method thereof for treating chalazion, side
In: raw Radix Astragali, dried orange peel can be cooperateed with mutually, and gain is complementary, play the role of benefiting qi and raising yang, qi-regulating, in tune, item of relieving inflammation or internal heat；Ginger
The tuber of pinellia, the root of Dahurain angelica and gypsum compatible use, the effect of playing apocenosis myogenic, clearing heat-fire；It is aided with Poria cocos, licorice and jujube three again
Taste medicine, play invigorate the spleen and benefit qi, mental-tranquilization the effect of.But based on the party is mainly relieved inflammation or internal heat with promoting the circulation of qi, to carbuncle that disappears dissipating bind effect also to
It further increases.
Prior art CN105079195A provides a kind of medicine and preparation method thereof for treating chalazion, controls cape jasmine 8-12
Gram, 13-17 grams of gypsum, 8-12 grams of the coptis, 13-17 grams of Fructus Forsythiae, 8-12 grams of radix scutellariae, 4-8 grams of Radix Glycyrrhizae, 8-12 grams of Fructus Aurantii, perillaseed 8-
12 grams, 8-12 grams of dried orange peel, 8-12 grams of Radix Angelicae Sinensis, 8-12 grams of schizonepeta, 8-12 grams of radix saposhnikoviae.Preferable therapeutic effect is had to phlegm thermal resistance.
But the party does not have heat toxin from outer solution, and quick purulence dissipates, pyosis and the effect of inducing diuresis for treating strangurtia toxin expelling.
Summary of the invention
It is the Chinese materia medica preparation for treating chalazion the present invention relates to field of medicaments.Chalazion is ophthalmology common disease, is generally required
Operation excision.Chinese medicine thinks that its interpretation of the cause, onset and process of an illness is phlegm stagnation in collateral, can treat graupel grain using pharmaceutical composition and its preparation of the invention
It is swollen, so that mass is slowly dissipated, woth no need to operative treatment, effective percentage is adapted to all groups up to 95% or more.
The invention is realized by the following technical scheme, a kind of pharmaceutical composition for treating chalazion, by peach kernel 30-120g,
It is radices trichosanthis 10-30g, sargentodoxa cuneata 10-20g, root of Chinese clematis 10-50g, arisaema cum bile 10-50g, root of Dahurain angelica 10-30g, dianthus superbus 10-30g, big
Yellow 10-30g, Fructus Forsythiae 10-30g, borneol 2-5g composition.
Fructus Forsythiae is monarch drug in a prescription in side；Again with peach kernel, rheum officinale, sargentodoxa cuneata, arisaema cum bile, borneol altogether for ministerial drug.
Wherein, Fructus Forsythiae is the dry fruit of Oleaceae plants Fructus Forsythiae Forsythia suspensa (Thnub.) Vahl.Tool
There is the effect of clearing heat and detoxicating, dispersing swelling and dissipating binds.
Peach kernel is rosaceous plant peach Prunus persica (L.) Batsch or mountain peach Prunus davidiana
(Cars.) dry mature seed of Franch..With promoting blood circulation, the effect of relax bowel and defecation.
Rheum officinale is section, family plant sorrel Rheum palmatum L. Rheum tanguticum Maxim Rheum tangicum
The drying root and rhizome of Maxim.ex Balf. or Rheum officinale Rheum officinale Baill..It is cool with the logical intestines that purge heat
The effect of blood removing toxic substances, dispelling stasis of blood and stimulating the menstrual flow.
Sargentodoxa cuneata is the dry of plants of Lardizabalaceae sargentodoxa cuneata Sargentodoxa cuneata (Oliv.) Rehd.et Wils.
Dry rattan.With clearing heat and detoxicating, the effect of promoting blood circulation, wind-dispelling.
Arisaema cum bile is that the fine powder of Rhizoma Arisaematis (processed) processes from strand with ox, sheep or pig's bile, or for unprocessed Arisaema erubescens fine powder and ox,
Sheep or pig's bile is fermented is process.With clearing heat and eliminating phlegm, the effect of dispelling wind and relieving convulsion.
Borneol has the effect of inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain.
The root of Dahurain angelica is umbelliferae root of Dahurain angelica Angelica dahurica (Fisch.exHOffm.) Benth.et Hook.f.
Or Radix angelicae dahuricae Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f.var.formosana
(Boiss.) dry root of Shan et Yuan.It dehumidifies with relieve heat, the effect of sensible analgesic, detumescence and apocenosis.
Radices trichosanthis is cucurbitaceous plant snakegourd Trichosanthes kirilowii Maxim. or trichosanthes rosthornii Harms
The dry root of Trichosanthes rosthornii Harms.There is the effect of clearing heat and promoting fluid detumescence and apocenosis.
Dianthus superbus is pinkwort dianthus superbus Dianthus superbus L.'s or China pink Dianthus chinensis L.
Dry aerial parts.There is the effect of inducing diuresis for treating strangurtia, blood-breaking promoting menstruation.
The root of Chinese clematis is ranunculaceae plant root of Chinese clematis Clematis chinensis Osbeck, Clematis hexapetala Clematis
The drying root and rhizome of hexapetala Pall. or northeast clematis Clematis manshurica Rupr..With wind-dispelling
Dehumidifying, the effect of removing obstruction in channels to relieve pain.
Fang Xie: Fructus Forsythiae taste bitter and cold in side, most kind clearing heat and detoxicating, carbuncle that disappears dissipating bind, forefathers are referred to as to call " sore panacea ", therefore weight
With for monarch.So it is applied alone clearing heat and detoxicating, then qi depression to blood stasis difficulty disappears, and swollen knot does not dissipate, and with peach kernel, rheum officinale, sargentodoxa cuneata, arisaema cum bile, ice
Piece, clearing heat and detoxicating, blood-activating and qi-promoting analgesic, detumescence and apocenosis is altogether ministerial drug.Sore is stopped between skin space between skin and muscles more from the beginning of, heresy,
More matched with the pungent scattered root of Dahurain angelica, leads to stagnant and dissipate its knot, make heat toxin from outer solution；Mechanism of qi retardance often can lead to liquid and be polymerized to phlegm, therefore match
With radices trichosanthis clearing heat and eliminating phlegm dissipating bind, dianthus superbus inducing diuresis for treating strangurtia, blood circulation can make purulence not at disappearing；The root of Chinese clematis is apt to walk without keeping, and leads to
The row twelve regular channels, saturating pyosis is hard, and purulence can be made at bursting, be adjutant.Radix Glycyrrhizae is clearing heat and detoxicating, and coordinating the drug actions of a prescription, all medicines share, altogether
Play clearing heat and detoxicating, rclicving swelling and disintegrating mass, the function of promoting blood circulation and stopping pain.Dissipate the non-winner of purulence i.e., winner is burst, and is good dose of analgesic disinfection
?.
We can be made into Chinese medicine ointment, powder is applied with, and can also be used as decoction oral.Our main traditional Chinese medicinal components can be made into drop
Eye agent and Eye ointments, eyedrops etc..
And specifically, it is preferable to first extract, active principle extract Eye ointments, eyedrops is then made.
The present invention provides foregoing pharmaceutical compositions to prepare the medicinal purposes of chalazion.
Described purposes effect refers to clearing heat and eliminating phlegm, activating microcirculation and removing stasis medicinal, carbuncle that disappears dissipating bind.
The purposes, which cures mainly, to be referred to: stopping up poly-, yang syndrome, the half yin and half yang of ulcerative carbuncle pyogenic infections caused by qi depression to blood stasis phlegm knot by heat toxin
Card, initial stage can promote to subside, and stadium suppurations promotes apocenosis.
The effect of the present invention compared with the existing technology includes:
(1) pharmaceutical composition that the prior art has no of the invention is report, is solved according to aforementioned side, the present invention is by each drug
Performance realizes the synergistic action effect treatment chalazion of each prescription medicine of prescription according to monarch principle.
(2) prior art is mostly eliminated using swollen i.e. as action, and it is slow to work, in practice, using pharmaceutical composition of the invention
Object and its preparation can treat chalazion, and mass is made slowly to dissipate, efficient up to 95% or more woth no need to operative treatment.
Specific embodiment
The reality that the present invention and its effective technical effect are described in further detail, but invented below with reference to embodiment
It is without being limited thereto to apply mode.
Embodiment 1
A kind of pharmaceutical composition for treating chalazion, group become peach kernel 30g, radices trichosanthis 10g, sargentodoxa cuneata 10g, the root of Chinese clematis
10g, arisaema cum bile 10g, root of Dahurain angelica 10g, dianthus superbus 10g, rheum officinale 10g, Fructus Forsythiae 10g, borneol 2g.
Embodiment 2
A kind of pharmaceutical composition for treating chalazion, group become peach kernel 120g, radices trichosanthis 30g, sargentodoxa cuneata 20g, the root of Chinese clematis
50g, arisaema cum bile 50g, root of Dahurain angelica 30g, dianthus superbus 30g, rheum officinale 30g, Fructus Forsythiae 30g, borneol 5g.
Embodiment 3
A kind of pharmaceutical composition for treating chalazion, group become peach kernel 75g, radices trichosanthis 20g, sargentodoxa cuneata 15g, the root of Chinese clematis
30g, arisaema cum bile 30g, root of Dahurain angelica 20g, dianthus superbus 20g, rheum officinale 20g, Fructus Forsythiae 20g, borneol 3.5g.
Embodiment 4
Using the pharmaceutical composition of embodiment 1 or 2 or 3, does decoction decoction and take orally, decoction can be according to conventional Chinese materia medica preparation
Preparation method, for example, adding water not have about 10 centimetres of drug using iron ware, preferably first impregnating 30 minutes, with high heat first
After boiling, uses mild fire instead and decoct 40-60 minutes slowly, merge after decoction 2-3 times, be suitble to take 3 dosage within one.
Embodiment 5
Using the pharmaceutical composition of embodiment 1 or 2 or 3, originally Chinese medicine can be made according to conventional Chinese materia medica preparation preparation method
Paste, powder are applied with.
Embodiment 6
Using the pharmaceutical composition of embodiment 1 or 2 or 3, originally can first be carried out according to conventional Chinese materia medica preparation preparation method
It extracts, active principle extract Eye ointments is then made.
Embodiment 7
Case crowd 200, meet chalazion diagnostic criteria: the visible mass of eyelid, color of the leather is as usual, and what is pushed away is removable,
Pressure not bitterly
Specifically used method: being made paste for this pharmaceutical composition of embodiment 1 and be applied with, and once a day, 28- is used continuously
60 days.
Clinical effectiveness: can treat chalazion using pharmaceutical composition and its preparation of the invention, mass made slowly to dissipate,
It is efficient up to 95% or more woth no need to operative treatment.
The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that
Specific implementation of the invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs, exist
Under the premise of not departing from present inventive concept, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to of the invention
Protection scope.
Claims (8)
1. a kind of pharmaceutical composition for treating chalazion, which is characterized in that composition is by peach kernel 30-120g, radices trichosanthis 10-30g, big
Blood rattan 10-20g, root of Chinese clematis 10-50g, arisaema cum bile 10-50g, root of Dahurain angelica 10-30g, dianthus superbus 10-30g, rheum officinale 10-30g, Fructus Forsythiae 10-
30g, borneol 2-5g composition.
2. a kind of pharmaceutical composition for treating chalazion, which is characterized in that Fructus Forsythiae is monarch drug in a prescription in side；Again with peach kernel, rheum officinale, big blood
Rattan, arisaema cum bile, borneol are ministerial drug altogether.
3. a kind of pharmaceutical composition for treating chalazion, which is characterized in that use pharmaceutical composition of any of claims 1 or 2
Chinese medicine ointment is made in composition, powder is applied with；It can also be used as decoction oral；It may be made as eye drops and Eye ointments, eyedrops.
4. a kind of pharmaceutical composition for treating chalazion according to claim 3, which is characterized in that first extract, so
After active principle extract Eye ointments, eyedrops is made.
5. pharmaceutical composition described in claim 1 is preparing the medicinal purposes of chalazion.
6. pharmaceutical composition as claimed in claim 2 is preparing the medicinal purposes of chalazion.
7. purposes according to claim 5 or 6, which is characterized in that described purposes effect refers to clearing heat and eliminating phlegm, promoting blood circulationization
The stasis of blood, carbuncle that disappears dissipating bind.
8. purposes according to claim 5 or 6, which is characterized in that the purposes, which cures mainly, to be referred to: stopping up poly-, the stagnation of the circulation of vital energy by heat toxin
The yang syndrome of ulcerative carbuncle pyogenic infections caused by blood stasis phlegm knot, half yin and half yang card, initial stage can promote to subside, and stadium suppurations promotes apocenosis.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112107609A (en) * | 2020-11-10 | 2020-12-22 | 贵州益佰制药股份有限公司 | Application of Jingu lotus preparation in preparing medicine for treating chalazion |
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