CN104274555B - Traditional Chinese medicine composition for treating rheumatism, ointment and preparation method of traditional Chinese medicine composition - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating rheumatism, an ointment and a preparation method thereof, which can effectively solve the problems of poor efficacy and large toxic and side effects of the medicine for treating rheumatism. The technical proposal comprises the following raw materials by weight: angelica 13‑17g, Chuanxiong 9‑11g, Sanqi 9‑11g, Salvia 9‑11g, Eucommia 9‑11g, Sangjisheng 13‑17g, Gentiana 9‑11g, Duhuo 9‑11g, Notopterygium 9‑11g, Paeoniae Alba 13‑17g 17g, Fangfeng 13-17g, Frankincense 9-11g, Myrrh 9-11g, Papaya 9-11g, Aconitum 4-6g, Radix Glycyrrhizae 4-6g, the Chinese medicine composition ointment of the present invention adopts pure natural raw material Chinese medicine preparation The organic combination of various drugs, mutual support, reasonable compatibility, rich raw materials, simple method, improve local tissue nutrition metabolism, promote tissue regeneration, produce analgesic and anti-inflammatory effects, and have no toxic side effects, no pain for patients, easy to accept , can be used for a long time, and has good anti-inflammatory, analgesic and immunosuppressive effects, good curative effect, low cost, and is a great innovation in the treatment of rheumatism drugs.

Description

A traditional Chinese medicine composition for treating rheumatism, ointment and preparation method thereof

technical field

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating rheumatism, an ointment and a preparation method thereof.

Background technique

Rheumatism is a group of diseases mainly invading joints, bones, muscles, blood vessels and related soft or connective tissues, most of which are autoimmune diseases. The onset is mostly hidden and slow, the course of the disease is long, and most of them have genetic predisposition. Motherland's medical science is referred to as arthralgia syndrome, and "Huangdi Neijing": "the combination of wind, cold and dampness is arthralgia". Includes rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, psoriasis, rheumatic fever, relapsing rheumatism, lupus erythematosus, arteritis, polymyositis, tenosynovitis, fibromyalgia, inflammatory bowel disease arthritis , Rheumatic heart disease, etc. At present, rheumatism is a difficult medical problem in the world, and there is no breakthrough in the research of rheumatism, and there is no medicine to cure this kind of disease at the same time. Western medicine mainly treats this disease with non-steroidal anti-inflammatory drugs, immunosuppressants and hormones, and the side effects of long-term medication cannot be ignored. And traditional Chinese medicine shows its unique advantage day by day in the treatment of rheumatism, contains great potential.

Contents of the invention

For above-mentioned situation, in order to solve the defect of prior art, the purpose of the present invention is exactly to provide a kind of Chinese medicine composition for the treatment of rheumatism, ointment and preparation method thereof, can effectively solve the drug effect of treatment of rheumatism not good, toxic and side effects The problem.

The technical scheme solved by the present invention is a traditional Chinese medicine composition for treating rheumatism, comprising the following raw materials by weight: Angelica 13-17g, Rhizoma Chuanxiong 9-11g, Panax notoginseng 9-11g, Salvia miltiorrhiza 9-11g, Eucommia 9-11g , Sangjisheng 13-17g, Gentiana 9-11g, Duhuo 9-11g, Notopterygium 9-11g, Paeoniae Alba 13-17g, Fangfeng 13-17g, Frankincense 9-11g, Myrrh 9-11g, Papaya 9-11g, Chuanwu 4-6g, licorice 4-6g.

The composition of the invention is made of pure natural raw material Chinese medicine, various medicines are organically coordinated, mutually supported, reasonable in compatibility, rich in raw materials, good in curative effect and low in cost, and is a great innovation in medicine for treating rheumatism.

A traditional Chinese medicine composition ointment for treating rheumatism, comprising the following raw materials by weight: Angelica 13-17g, Chuanxiong 9-11g, Panax notoginseng 9-11g, Salvia miltiorrhiza 9-11g, Eucommia 9-11g, Sangjisheng 13-17g , Gentiana 9-11g, Duhuo 9-11g, Notopterygium 9-11g, Paeoniae Alba 13-17g, Fangfeng 13-17g, Frankincense 9-11g, Myrrh 9-11g, Papaya 9-11g, Aconitum 4-6g, Licorice 4-6g, glycerin 350-450g, methylcellulose 670-770g, sodium benzoate 3-5g and distilled water 2300-3300mL;

A preparation method of a traditional Chinese medicine composition ointment for the treatment of rheumatism, comprising the following steps:

(1) Angelica 13-17g, Chuanxiong 9-11g, Panax notoginseng 9-11g, Salvia miltiorrhiza 9-11g, Eucommia 9-11g, Sangji 13-17g, Gentiana chinensis 9-11g, Duhuo 9-11g, Qianghuo 9-11g , Radix Paeoniae Alba 13-17g, Fangfeng 13-17g, Frankincense 9-11g, Myrrh 9-11g, Papaya 9-11g, Zhichuan Aconitum 4-6g, Licorice 4-6g, crushed into 100 mesh fine powder, set aside;

(2) Dissolve 350-450g of glycerin and 3-5g of sodium benzoate in 2300-3300mL of distilled water, then add 670-770g of methyl cellulose, stir evenly, and place it in a gel state to obtain a water-soluble ointment base;

(3) Add the fine powder of step (1) into the water-soluble ointment base, and stir evenly.

The traditional Chinese medicine composition ointment of the present invention is made of pure natural raw material Chinese medicine, and various medicines are organically coordinated, mutually supported, reasonable in compatibility, rich in raw materials, simple in method, selects the way of topical administration, and selects non-toxic, tasteless, moisturizing The ointment, which is easy to absorb through the skin, is used as the matrix, which can be applied locally on the patient and directly acts on the affected area. The drug is transported through the stratum corneum and absorbed into the blood through the deep capillaries of the epidermis. At the same time, the ointment can form a kind of sweat locally The relatively closed state that is difficult to evaporate and diffuse increases the water content of the stratum corneum, and the stratum corneum expands into a porous state, which is conducive to drug penetration. The aromatic components in traditional Chinese medicine can stimulate local blood vessels to expand, accelerate blood flow, and facilitate drug penetration and absorption. Local vasodilation, accelerated blood flow, increased tissue cell membrane permeability, improved local tissue nutrition metabolism, promoted tissue regeneration, produced analgesic and anti-inflammatory effects, and had no toxic side effects, no pain for patients, easy to accept, long-term use, and has Good anti-inflammatory, analgesic and immunosuppressive effects, good curative effect, low cost, is a great innovation in the treatment of rheumatic diseases.

detailed description

The specific implementation of the present invention will be described in further detail below in conjunction with the examples.

Example 1

The traditional Chinese medicine composition for treating rheumatism in this embodiment includes the following raw materials by weight: Angelica 13g, Rhizoma Chuanxiong 9g, Panax notoginseng 9g, Salvia miltiorrhiza 9g, Eucommia 9g, Sangjisheng 13g, Gentiana chinensis 9g, Duhuo 9g, Qianghuo 9g, Radix Paeoniae Alba 13g, Fangfeng 13g, Frankincense 9g, Myrrh 9g, Papaya 9g, Aconitum 4g, Licorice 4g.

The traditional Chinese medicine composition ointment for the treatment of rheumatism in this embodiment includes the following raw materials by weight: Angelica 13g, Rhizoma Chuanxiong 9g, Panax notoginseng 9g, Salvia miltiorrhiza 9g, Eucommia ulmoides 9g, Sangjisheng 13g, Gentiana chinensis 9g, Duhuo 9g, Notopterygium 9g, Radix Paeoniae Alba 13g, Fangfeng 13g, Frankincense 9g, Myrrh 9g, Papaya 9g, Aconitum 4g, Licorice 4g, Glycerin 350g, Methylcellulose 670g, Sodium Benzoate 3g and Distilled Water 2300mL.

The preparation method of the Chinese medicine composition ointment for the treatment of rheumatism of the present embodiment may further comprise the steps:

(1) Angelica 13g, Chuanxiong 9g, Sanqi 9g, Salvia 9g, Eucommia 9g, Sangji 13g, Gentiana 9g, Duhuo 9g, Notopterygium 9g, Paeoniae Alba 13g, Fangfeng 13g, Frankincense 9g, Myrrh 9g, Papaya 9g, Aconitum 4g and licorice 4g are crushed into 100 mesh fine powder, set aside;

(2) Dissolve 350g of glycerin and 3g of sodium benzoate in 2300 mL of distilled water, then add 670g of methylcellulose, stir evenly, and place until gel-like to obtain a water-soluble ointment base;

(3) Add the fine powder of step (1) into the water-soluble ointment base, and stir evenly.

Example 2

The traditional Chinese medicine composition for treating rheumatism in this embodiment includes the following raw materials by weight: Angelica 15g, Chuanxiong 10g, Panax notoginseng 10g, Salvia miltiorrhiza 10g, Eucommia ulmoides 10g, Sangji 15g, Gentiana chinensis 10g, Duhuo 10g, Notopterygium 10g, Radix Paeoniae Alba 15g, Fangfeng 15g, Frankincense 10g, Myrrh 10g, Papaya 10g, Zhichuan Aconitum 5g, Licorice 5g.

The traditional Chinese medicine composition ointment for treating rheumatism of this embodiment includes the following raw materials by weight: Angelica 15g, Chuanxiong 10g, Panax notoginseng 10g, Salvia miltiorrhiza 10g, Eucommia ulmoides 10g, Sangjisheng 15g, Gentiana 10g, Duhuo 10g, Notopterygium 10g, Radix Paeoniae Alba 15g, Fangfeng 15g, Frankincense 10g, Myrrh 10g, Papaya 10g, Aconitum 5g, Licorice 5g, Glycerin 400g, Methylcellulose 720g, Sodium Benzoate 4g and Distilled Water 2800mL.

The preparation method of the Chinese medicine composition ointment for the treatment of rheumatism of the present embodiment may further comprise the steps:

(1) Angelica 15g, Chuanxiong 10g, Panax notoginseng 10g, Salvia miltiorrhiza 10g, Eucommia 10g, Sangji15g, Gentiana 10g, Duhuo 10g, notopterygium 10g, white peony root 15g, Fangfeng 15g, frankincense 10g, myrrh 10g, papaya 10g, Aconitum 5g and licorice 5g were crushed into 100 mesh fine powder, set aside;

(2) Dissolve 400g of glycerin and 4g of sodium benzoate in 2800 mL of distilled water, then add 720g of methylcellulose, stir evenly, and place until gel-like to obtain a water-soluble ointment base;

(3) Add the fine powder of step (1) into the water-soluble ointment base, and stir evenly.

Example 3

The traditional Chinese medicine composition for treating rheumatism of this embodiment includes the following raw materials by weight: Angelica 17g, Chuanxiong 11g, Panax notoginseng 11g, Salvia miltiorrhiza 11g, Eucommia ulmoides 11g, Sangjisheng 17g, Gentiana chinensis 11g, Duhuo 11g, Notopterygium 11g, Radix Paeoniae Alba 17g, Fangfeng 17g, Frankincense 11g, Myrrh 11g, Papaya 11g, Aconitum 6g, Licorice 6g.

The traditional Chinese medicine composition ointment for treating rheumatism of this embodiment includes the following raw materials by weight: Angelica 17g, Rhizoma Chuanxiong 11g, Panax notoginseng 11g, Salvia miltiorrhiza 11g, Eucommia ulmoides 11g, Gentiana ulmoides 11g, Duhuo 11g, Qianghuo 11g, Radix Paeoniae Alba 17g, Fangfeng 17g, frankincense 11g, myrrh 11g, papaya 11g, aconitum 6g, licorice 6g, glycerin 450g, methylcellulose 770g, sodium benzoate 5g and distilled water 3300mL.

The preparation method of the Chinese medicine composition ointment for the treatment of rheumatism of the present embodiment may further comprise the steps:

(1) Angelica 17g, Chuanxiong 11g, Sanqi 11g, Salvia miltiorrhiza 11g, Eucommia 11g, Sangjisheng 17g, Gentiana 11g, Duhuo 11g, Notopterygium 11g, Baishao 17g, Fangfeng 17g, frankincense 11g, myrrh 11g, papaya 11g, Aconitum 6g and licorice 6g are crushed into 100 mesh fine powder, set aside;

(2) Dissolve 450g of glycerin and 5g of sodium benzoate in 3300mL of distilled water, then add 770g of methyl cellulose, stir evenly, and place until gelatinous to obtain a water-soluble ointment base;

(3) Add the fine powder of step (1) into the water-soluble ointment base, and stir evenly.

It should be pointed out in the present invention that the technical core claimed in the present invention is the prescription (Chinese medicine compound), and all decoctions, pills, powders or capsules made according to the Chinese medicine compound all belong to the protection scope of the present invention.

Among the above drugs, among them:

Angelica, also known as Gangui, Horsetail Angelica, Qinna, Horsetail Angelica, Yungui, and Angelica sinensis, is a perennial herb plant distributed in Gansu, Yunnan, Sichuan, Qinghai, Shaanxi, Hunan, Hubei, Guizhou and other places in China, and is cultivated in various places . The root of Angelica sinensis can be used as medicine and is one of the most commonly used traditional Chinese medicines. Indications: Enriching blood and promoting blood circulation, regulating menstruation and relieving pain, moistening intestines and laxative. For blood deficiency and yellow complexion, dizziness and palpitations, irregular menstruation, amenorrhea dysmenorrhea, abdominal pain due to deficiency and cold, constipation due to dryness of the intestine, rheumatic arthralgia, injury from falls, carbuncle and sore.

Ligusticum Chuanxiong, a perennial herb, is often used to promote blood circulation, expel wind and relieve pain. Ligusticum chuanxiong is pungent, warm, fragrant and dry. It has a wide range of functions of promoting blood circulation and removing blood stasis, suitable for stagnation of various diseases; dispelling wind and relieving pain, has very good effects, and can cure head wind, headache, rheumatic arthralgia and other diseases. In the past, Chuanxiong was called the qi medicine in the blood, and almost said that it contained pungent, relieves depression, tonic, pain relief and other functions. Do not use.

Panax notoginseng, also known as Sanqi, Tianqi, Tusanqi, Xueshancao, also known as Zhaoshen, Xueshen, Panax notoginseng, Panax notoginseng, etc. in ancient times, has the effects of dispelling blood stasis, stopping bleeding, reducing swelling and relieving pain . Indications for hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic bleeding, chest and abdomen tingling, tumbling pain.

Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza. Most of them are cultivated, and they are found in most parts of the country. Mainly produced in Sichuan, Anhui, Jiangsu, Henan, Shanxi and other places. Excavated in spring and autumn, removed stems and leaves, washed, moistened, cut into thick slices, and dried in the sun. Used raw or roasted with wine. Efficacy: promoting blood circulation and regulating menstruation, dispelling blood stasis and relieving pain, cooling blood and eliminating carbuncle, eliminating annoyance and calming nerves. Indications for irregular menstruation, amenorrhea, dysmenorrhea, postpartum stasis abdominal pain, blood stasis heartache, epigastric pain, abdominal mass accumulation, bruises, rheumatic arthralgia, sore carbuncle, swollen toxin, upset and insomnia.

Eucommia ulmoides is the bark of Eucommia ulmoides. Mainly produced in Sichuan, Yunnan, Guizhou, Hubei and other places. Harvest from April to June, remove the rough skin and pile up "sweating" until the inner skin turns purple-brown, and dry in the sun. Used raw or fried in salt water. Efficacy: nourish liver and kidney, strengthen muscles and bones, and prevent miscarriage. "Shen Nong's Materia Medica": "maintains back pain, nourishes the middle, nourishes the essence, strengthens the muscles and bones, strengthens the mind, eliminates itching and dampness in the yin, and urinates. Long-term use." "Famous Doctors": " Cure soreness in the feet, don't want to trample on the ground."

Mulberry parasitism, also known as peach tree parasitism, neem parasitism, is the dry leafy stems and branches of the Morus parasiticae plant Sang parasitism. Efficacy: dispelling rheumatism, nourishing liver and kidney, strengthening muscles and bones, anti-abortion. Indications: rheumatic soreness of the waist and knees, weakness of muscles and bones, deficiency of liver and kidney, profuse metrorrhagia, hemorrhage during pregnancy, restless fetal movement.

Gentiana is the dry root of Gentianae plants Gentiana, Gentiana twist, Gentiana thick stem or Gentiana small. The first three are commonly called "Gentica Qin" and "Genia Mahua" respectively according to their shapes, and one is commonly called "Gentica Xiaoqin". Produced in Shaanxi, Gansu, Inner Mongolia, Sichuan and other places. Efficacy: dispelling rheumatism, dredging collaterals and relieving pain, reducing asthenia heat, clearing damp heat. "Shen Nong's Materia Medica": "mainly cold and heat pathogens, cold-damp wind numbness, joint pain, drainage, and urination."

The solitary life is the dry root of the Umbelliferae plant Angelica barbata. Mainly produced in Sichuan, Hubei, Anhui and other places. Excavate in early spring or late autumn, remove fibrous roots and silt, let the kang dry until it is half dry, pile it up for 2 to 3 days, let it soften and then kang until it is completely dry. Slice and serve raw. "Materia Medica": "specializes in treating rheumatism in the lower energizer, bipedal pain and numbness, dampness, itching and spasm." Modern research has shown that Duhuo has anti-inflammatory, analgesic and sedative effects; it has inhibitory effects on platelet aggregation; it also has antihypertensive effects, but not Long-lasting; the citrus lactone and xanthoxylin contained in it have photosensitizing and anti-tumor effects.

Notopterygium, also known as Qiangqing, Qiang Hushishi, Huwangshishi, Qianghua, Tuifengshishi, black medicine, indications: warming the kidney and helping yang, inhaling qi, and stopping diarrhea. Used for impotence and nocturnal emission, enuresis and frequent urination, cold pain in the waist and knees, asthma due to kidney deficiency, and diarrhea at dawn; external use for vitiligo, alopecia areata; exogenous wind-cold, headache without sweating, oily cold-damp arthralgia, feng shui edema, sore swollen toxin.

Radix Paeoniae Alba is the root of Paeoniae Alba. It is mainly produced in Zhejiang, Anhui, Sichuan and other places, so it is also known as Hangshao, Haoshao and Chuanshao. Efficacy: Nourishing blood and restraining yin, softening liver and relieving pain, calming liver yang. Indications of deficiency of liver blood, chest, hypochondrium, epigastric and abdominal pain, extremity spasm and acute pain, headache and dizziness.

Fangfeng, also known as Tongyun, Huiyun, Huicao, is a perennial herb with effects: expelling wind and relieving exterior, eliminating dampness and relieving pain, relieving spasm, and relieving itching. Indications: exogenous wind and cold; headache and body pain; rheumatic arthralgia; joint pain; abdominal pain and diarrhea; intestinal wind and blood; tetanus; rubella and itching; early sores.

Frankincense, whose real name is Xunlu, also known as Xunluxiang, Horsetail Incense, Nipple Incense, Daxiang, Tianzexiang, Molexiang, Dajialuoxiang, etc., can regulate Qi and blood circulation, relieve pain, and chase poison. Control qi and blood stagnation, trusted subordinate's pain, carbuncle sore swelling, bruises, dysmenorrhea, postpartum blood stasis and tingling pain.

Myrrha, has another name called the end medicine, also known as Myrrha Ming, making Myrrha, burning Myrrha, frying Myrrha with vinegar, giving birth to Myrrha, giving birth to Myrrha and other other names. Cure mainly chest and abdomen stasis and pain, dysmenorrhea, amenorrhea, lump in the abdomen, bruises, carbuncle sores, intestinal abscess, red eyes and swelling. It has the effects of promoting blood circulation, relieving pain, reducing swelling and promoting muscle growth.

Papaya, also known as "wrinkled papaya", is the dry and nearly ripe fruit of the Rosaceae plant Begonia chinensis. It is mainly produced in Anhui, Sichuan, Hubei, Zhejiang and other places. Those produced in Xuancheng, Anhui are called "Xuan Papaya". The quality is good. The fruit is harvested when the fruit is green and yellow in summer and autumn. dry. Slice and serve raw. It has the effects of relaxing tendons and activating collaterals, harmonizing stomach dampness, and is mainly used for the treatment of soreness and pain of waist and knee joints, rheumatism, beriberi and swollen pain.

Chuanwu, the Chinese name is derived from Chuanwu, and its aliases are Eerhua, Tiehua, and Wudu. It can dispel wind and dampness, warm the meridian and relieve pain. For anemofrigid-damp arthralgia, mastalgia, distending pain in the chest, arthralgia, trusted subordinate's cold pain, colic caused by cold, anesthesia for relieving pain.

Licorice, also known as Guolao, sweet grass, Ural licorice, sweet root. It is the root and rhizome of leguminous licorice, bulging licorice or glabra. It has the effects of invigorating the spleen and replenishing qi, relieving spasms and relieving pain, clearing away heat and detoxification, and harmonizing various medicines. Indications of pulse knot and generation, palpitation, extremity contraction and acute pain, food and medicine poisoning, and reconcile the properties of the medicine.

Among the above-mentioned medicines, the main effect of angelica is to nourish blood and activate blood circulation, regulate menstruation and relieve pain, and is especially good at treating rheumatic arthralgia, traumatic injury, carbuncle and sore; points, the downlink can reach the sea of blood. It has a wide range of functions of promoting blood circulation and removing blood stasis, suitable for stagnation of various diseases; dispelling wind and relieving pain, and has very good effects; it is the king drug together with the two drugs of angelica. Radix Notoginseng dissipates blood stasis to stop bleeding, reduces swelling and relieves pain; Salvia miltiorrhiza promotes blood circulation to promote menstrual flow, dissipates blood stasis and relieves pain; Eucommia nourishes liver and kidney, strengthens bones and muscles; Sangjisheng dispels wind and dampness, nourishes liver and kidneys, strengthens muscles and bones; the four medicines are ministerial drugs. Gentiana chinensis dispels wind-damp, relaxes tendons and collaterals and sharpens joints; Duhuo treats rheumatism in the lower energizer, bipedal pain and numbness; notopterygium warms kidneys and helps yang, absorbs qi; papaya relaxes tendons and activates collaterals, harmonizes stomach and resolves dampness, arthralgia due to dampness, and constriction of tendons and arteries; White peony nourishes blood and softens liver, relieves spasm and pain, calms liver yang, nourishes blood and harmonizes blood with angelica, relieves spasm and relieves pain with licorice, softens liver and relaxes tendons; Dehumidification, warming the meridian and relieving pain; anti-wind and expelling wind, relieving the exterior, eliminating dampness and relieving pain, relieving spasm, relieving itching, eliminating internal and external wind, and serving as an adjuvant altogether. Licorice reconciles various medicines and also acts as medicine. The effective combination of all prescriptions, mutual support, careful selection of medicines, rigorous prescriptions, and precise compatibility, play a total role in expelling wind and eliminating numbness, promoting blood circulation and relieving pain. This prescription has been clinically applied and has achieved good results. The relevant information is as follows:

Criteria for selecting cases

1 General Information

From January 2011 to March 2014, 200 patients with rheumatism were treated with the medicine of the present invention, including 95 males and 105 females, the youngest was 17 years old, the oldest was 52 years old, and the average age was 37.2 years old; the shortest course of disease was 3 months , the longest being 16 years.

Diagnostic criteria

Formulated with reference to "Guiding Principles for Clinical Research of New Drugs of Traditional Chinese Medicine" and "Internal Medicine" (6th Edition). Rheumatism is a group of diseases mainly invading joints, bones, muscles, blood vessels and related soft or connective tissues, most of which are autoimmune diseases. The onset is mostly hidden and slow, the course of the disease is long, and most of them have genetic predisposition. Serological tests (antinuclear antibodies) and rheumatoid factor tests are of great significance for the diagnosis and differential diagnosis of rheumatic diseases.

clinical manifestations

⑴ Rheumatism mostly has joint lesions and symptoms, which can be as high as 70-80%, about 50% has only pain, and in severe cases, redness, swelling, heat, pain and functional impairment and other comprehensive inflammatory manifestations; most of them are multi-joint involvement. The size of the affected joints varies depending on the type of disease.

(2) Heterogeneity, that is, the same disease has different subtypes. Due to the genetic background, the pathogenesis is different, and the mechanism is also different. Therefore, the types of clinical manifestations, symptoms, severity and treatment responses are also different.

(3) Rheumatism is mostly a disease that invades multiple systems. The pathology of many diseases overlaps and the symptoms are similar. For example, MCTD (mixed connective tissue disease) is a typical manifestation of this kind.

(4) A variety of antibodies and immune complexes (CIC) appear in the serum, and can be deposited in tissues (skin, synovium) or organs (kidney, liver) to cause disease.

⑸ Raynaud's phenomenon often appears in this type of disease, such as SLE (lupus erythematosus), MCTD (systemic lupus erythematosus).

Inclusion and Exclusion Criteria

Inclusion criteria: Meet the diagnostic criteria for rheumatic diseases. Aged between 17-52 years old, morning stiffness, symmetrical and persistent joint pain, deformation, and the duration of the disease lasted for a minimum of 3 months. Those who have not received rheumatism treatment within 1 month, and have not used hormone preparations within half a year, have deformed joints intact without damage, and have no skin diseases.

Exclusion criteria: combined with malignant tumors, inflammatory and other endocrine diseases; women with severe irregular menstrual cycles; combined with serious primary diseases such as cardiovascular and cerebrovascular, liver, kidney, hematopoietic system, or mental illness; allergic constitution Or those who are known to be allergic to such drugs or components; those who are participating in other clinical drug experiments.

Therapeutic plan: the patient lies on his back, first washes the painful part, and directly sticks the traditional Chinese medicine composition ointment of the present invention on the painful part. Each ointment can be pasted for 3 days, with an interval of 1 day, and 20 days is a course of treatment. The relevant internal prescriptions prepared for the above diseases have better curative effect. Review once every 3 weeks, stop the drug for those who have recovered, and continue the drug treatment for those who have not recovered, and use the drug for a maximum of 3-6 courses of treatment. Women's menstrual period stops external application. Those who have local skin allergies on the patch can stop using it for 3 days or after symptomatic treatment, and then continue to use it. Other therapeutic drugs were stopped during treatment.

Efficacy criteria and results

Efficacy standard

Formulated in accordance with the State Administration of Traditional Chinese Medicine's "Diagnostic and Curative Criteria for Diseases and Syndromes of Traditional Chinese Medicine" and "Guidelines for Clinical Research of New Chinese Medicines for the Treatment of Rheumatoid Arthritis".

Cure: joint deformation and pain disappeared, serum examination or imaging examination showed rheumatism signs disappeared, and no recurrence 3 months after drug withdrawal.

Effective: joint deformation and pain disappear, and serum examination or imaging examination indicates that the signs of rheumatism have changed significantly or improved.

Ineffective: joint deformation and pain disappeared, serum examination or imaging examination showed no change in signs of rheumatism.

treatment result

After 200 cases of patients were treated, the clinical symptoms disappeared, and all the test indicators were normal, and 114 cases did not recur within 3 months of follow-up; the clinical symptoms improved significantly, and the test indicators were normal or close to normal in 75 cases; the clinical symptoms improved, and the curative effect Eleven cases were unstable. The cure rate was 57%, the improvement rate was 37.5%, and the total effective rate was 94.5%.

in conclusion

Known by above-mentioned situation: the present invention selects the approach of topical administration, selects nontoxic, tasteless, skin-moisturizing, easy-to-transdermal ointment for use as base. On the basis of summarizing many years of clinical experience and traditional external prescriptions, it is proposed that Chinese medicine combined with water-soluble mechanism can treat rheumatism, and the effect is remarkable. The drug is transported through the stratum corneum and absorbed into the blood by the deep capillaries of the epidermis. At the same time, the ointment can form a relatively closed state in which sweat is difficult to evaporate and diffuse locally, so that the water content of the stratum corneum is increased, and the stratum corneum expands into a porous state, which is conducive to drug penetration. . Aromatic components in traditional Chinese medicine can stimulate local blood vessel dilation in olives, accelerate blood flow, and facilitate drug penetration and absorption. Analgesic and anti-inflammatory effects. The production process is simple, the cost is low, the use is safe, the curative effect is good, the dose is constant, the local administration is uniform, the sustained release is uniform, and the ointment is used for treatment, the operation is simple, no toxic and side effects, no pain for the patient, easy to accept, and the cure rate is high The efficiency reaches 92%, which is an innovation in the treatment of rheumatic diseases and will make a significant creative contribution to improving human health.

Claims (5)

1. A traditional Chinese medicine composition ointment for the treatment of rheumatism, characterized in that it is made of the following raw materials: Angelica 13-17g, Rhizoma Chuanxiong 9-11g, Panax notoginseng 9-11g, Salvia miltiorrhiza 9-11g, Eucommia 9-11g , Sangjisheng 13-17g, Gentiana 9-11g, Duhuo 9-11g, Notopterygium 9-11g, Paeoniae Alba 13-17g, Fangfeng 13-17g, Frankincense 9-11g, Myrrh 9-11g, Papaya 9-11g, Aconitum 4-6g, licorice 4-6g, glycerin 350-450g, methylcellulose 670-770g, sodium benzoate 3-5g and distilled water 2300-3300mL. 2. a preparation method of Chinese medicine composition ointment as claimed in claim 1, is characterized in that, comprises the following steps: (1) Angelica 13-17g, Chuanxiong 9-11g, Panax notoginseng 9-11g, Salvia miltiorrhiza 9-11g, Eucommia 9-11g, Sangji 13-17g, Gentiana chinensis 9-11g, Duhuo 9-11g, Qianghuo 9-11g , Radix Paeoniae Alba 13-17g, Fangfeng 13-17g, Frankincense 9-11g, Myrrh 9-11g, Papaya 9-11g, Zhichuan Aconitum 4-6g, Licorice 4-6g, crushed into 100 mesh fine powder, set aside; (2) Dissolve 350-450g of glycerin and 3-5g of sodium benzoate in 2300-3300mL of distilled water, then add 670-770g of methyl cellulose, stir evenly, and place it in a gel state to obtain a water-soluble ointment base; (3) Add the fine powder of step (1) into the water-soluble ointment base, and stir evenly. 3. a preparation method of Chinese medicine composition ointment as claimed in claim 2, is characterized in that, comprises the following steps: (1) Angelica 13g, Chuanxiong 9g, Sanqi 9g, Salvia 9g, Eucommia 9g, Sangji 13g, Gentiana 9g, Duhuo 9g, Notopterygium 9g, Paeoniae Alba 13g, Fangfeng 13g, Frankincense 9g, Myrrh 9g, Papaya 9g, Aconitum 4g and licorice 4g are crushed into 100 mesh fine powder, set aside; (2) Dissolve 350g of glycerin and 3g of sodium benzoate in 2300 mL of distilled water, then add 670g of methylcellulose, stir evenly, and place until gel-like to obtain a water-soluble ointment base; (3) Add the fine powder of step (1) into the water-soluble ointment base, and stir evenly. 4. a preparation method of Chinese medicine composition ointment as claimed in claim 2, is characterized in that, comprises the following steps: (1) Angelica 15g, Chuanxiong 10g, Panax notoginseng 10g, Salvia miltiorrhiza 10g, Eucommia 10g, Sangji15g, Gentiana 10g, Duhuo 10g, notopterygium 10g, white peony root 15g, Fangfeng 15g, frankincense 10g, myrrh 10g, papaya 10g, Aconitum 5g and licorice 5g were crushed into 100 mesh fine powder, set aside; (2) Dissolve 400g of glycerin and 4g of sodium benzoate in 2800 mL of distilled water, then add 720g of methylcellulose, stir evenly, and place until gel-like to obtain a water-soluble ointment base; (3) Add the fine powder of step (1) into the water-soluble ointment base, and stir evenly. 5. a preparation method of Chinese medicine composition ointment as claimed in claim 2, is characterized in that, comprises the following steps: (1) Angelica 17g, Chuanxiong 11g, Sanqi 11g, Salvia miltiorrhiza 11g, Eucommia 11g, Sangjisheng 17g, Gentiana 11g, Duhuo 11g, Notopterygium 11g, Baishao 17g, Fangfeng 17g, frankincense 11g, myrrh 11g, papaya 11g, Aconitum 6g and licorice 6g are crushed into 100 mesh fine powder, set aside; (2) Dissolve 450g of glycerin and 5g of sodium benzoate in 3300mL of distilled water, then add 770g of methyl cellulose, stir evenly, and place until gelatinous to obtain a water-soluble ointment base; (3) Add the fine powder of step (1) into the water-soluble ointment base, and stir evenly.