CN117180387B

CN117180387B - Composition for treating wind-phlegm obstruction type peripheral facial paralysis and preparation method thereof

Info

Publication number: CN117180387B
Application number: CN202311338686.0A
Authority: CN
Inventors: 刘小东; 郑曦孜; 张玉龙; 张稳稳
Original assignee: Chongqing Medical and Pharmaceutical College
Current assignee: Chongqing Medical and Pharmaceutical College
Priority date: 2023-10-17
Filing date: 2023-10-17
Publication date: 2024-06-14
Anticipated expiration: 2043-10-17
Also published as: CN117180387A

Abstract

The invention discloses a composition for treating wind-phlegm obstruction type peripheral facial paralysis and a preparation method thereof, wherein the composition is prepared from the following raw materials in parts by weight: 90-140 parts of stiff silkworm, 40-80 parts of scorpion, 90-140 parts of arisaema cum bile, 40-80 parts of ligusticum wallichii, 60-100 parts of radix sileris, 90-140 parts of radix curcumae, 100-150 parts of poria cocos, 120-180 parts of tuber fleeceflower stem, 90-140 parts of polygala tenuifolia, 90-140 parts of astragalus membranaceus, 90-140 parts of dried orange peel and 30-60 parts of liquorice. The composition provided by the invention can be used for treating facial nerve ischemia and anoxia caused by wind-phlegm obstruction of collaterals type peripheral facial paralysis, and nerve paralysis caused by facial nerve compression, and recovering nerve functions.

Description

Composition for treating wind-phlegm obstruction type peripheral facial paralysis and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a composition for treating wind-phlegm obstruction type peripheral facial paralysis and a preparation method thereof.

Background

Facial paralysis, commonly called facial distortion, refers to acute non-suppurative facial neuritis in the mastoid of the neck, and is a clinical manifestation of peripheral facial paralysis, also called Bell's paralysis or idiopathic facial paralysis, which is one of the common and frequently-occurring clinical diseases. The incidence rate is 20/10 ten thousand-42.5/10 ten thousand, and the incidence rate is 258/10 ten thousand. There are many methods of clinical treatment. If the treatment is improper, the lifelong facial paralysis is often left, the face appearance is affected, and the pain is brought to patients and families.

The pathogenesis of peripheral facial paralysis is complex, the traditional Chinese medicine considers that the peripheral facial paralysis belongs to a meridian muscle symptom disease, from the aspect of human body structure, the meridian muscles of hands and feet of a human body are gathered on the face, the meridian muscles circulate in the superficial of the face so as to be easy to be invaded by exogenous evil, the patient is influenced by the invasion of exogenous evil, the vital qi is insufficient, the meridian qi cannot normally run, so that qi and blood blockage is caused, the body face loses nutrition supply, and the functional disorder of the muscles and the bones is caused; meanwhile, peripheral facial paralysis can also be caused by wind paralysis and blood obstruction, venation blockage and the like. Peripheral facial paralysis is mainly caused by wind-cold syndrome, and among wind-cold syndromes, deficiency of both healthy energy and qi deficiency are mainly caused.

The incidence rate of peripheral facial paralysis is high, and the peripheral facial paralysis can be divided into four types from the perspective of traditional Chinese medicine, namely: for the treatment of peripheral facial paralysis, it is indicated for cold syndrome. The wind-heat attack phenotype is mainly indicated for wind-dispelling and heat-clearing. For the treatment of internal stagnation of phlegm, it is mainly used for dispelling pathogenic wind and resolving phlegm. Wind-phlegm obstructing collaterals, which is mainly indicated for the treatment of eliminating phlegm, dredging collaterals, invigorating qi and nourishing blood. The patient can perform addition and subtraction treatment based on the medicine treatment.

The conventional method for treating peripheral facial paralysis mainly comprises western medicines, and the method can improve symptoms of patients, but has poor long-term curative effect and poor treatment prognosis. In recent years, the traditional Chinese medicine is widely used in the treatment of peripheral facial paralysis, has ideal effect, and can improve the recovery condition and the quality of life of patients. However, the traditional Chinese medicine for treating peripheral facial paralysis has different curative effects and poor pertinence, and the development of a safe and effective Chinese medicine preparation with simple preparation process and strong pertinence is needed.

Disclosure of Invention

In order to solve the technical problems, the first object of the present invention is to provide a composition for treating wind-phlegm obstruction type peripheral facial paralysis, and the second object is to provide a preparation method thereof, which can be used for treating facial nerve ischemia and hypoxia caused by wind-phlegm obstruction type peripheral facial paralysis, and nerve paralysis caused by facial nerve compression, and has the advantages of obvious effect, safety and reliability.

In order to achieve the first object, the technical scheme of the invention is as follows: the composition for treating wind-phlegm obstruction type peripheral facial paralysis is characterized by being prepared from the following raw materials in parts by weight: 90-140 parts of stiff silkworm, 40-80 parts of scorpion, 90-140 parts of arisaema cum bile, 40-80 parts of ligusticum wallichii, 60-100 parts of radix sileris, 90-140 parts of radix curcumae, 100-150 parts of poria cocos, 120-180 parts of tuber fleeceflower stem, 90-140 parts of polygala tenuifolia, 90-140 parts of astragalus membranaceus, 90-140 parts of dried orange peel and 30-60 parts of liquorice.

Preferably, the material is prepared from the following raw materials in parts by weight: 100 parts of stiff silkworm, 60 parts of scorpion, 100 parts of arisaema cum bile, 50 parts of ligusticum wallichii, 70 parts of radix sileris, 100 parts of radix curcumae, 110 parts of poria cocos, 140 parts of tuber fleeceflower stem, 110 parts of polygala tenuifolia, 120 parts of astragalus membranaceus, 100 parts of dried orange peel and 40 parts of liquorice.

Preferably, the material is prepared from the following raw materials in parts by weight: 110 parts of stiff silkworm, 70 parts of scorpion, 110 parts of arisaema cum bile, 50 parts of ligusticum wallichii, 80 parts of radix sileris, 120 parts of radix curcumae, 130 parts of poria cocos, 160 parts of tuber fleeceflower stem, 120 parts of polygala tenuifolia, 120 parts of astragalus membranaceus, 110 parts of dried orange peel and 50 parts of liquorice.

Preferably, the material is prepared from the following raw materials in parts by weight: 120 parts of stiff silkworm, 70 parts of scorpion, 130 parts of arisaema cum bile, 60 parts of ligusticum wallichii, 80 parts of radix sileris, 120 parts of radix curcumae, 130 parts of poria cocos, 170 parts of tuber fleeceflower stem, 130 parts of polygala tenuifolia, 130 parts of astragalus membranaceus, 120 parts of dried orange peel and 50 parts of liquorice.

The second object of the present invention is achieved by: a preparation method of a composition for treating wind-phlegm obstruction type peripheral facial paralysis is characterized by comprising the following steps: adding water into the raw materials, soaking for 15-25 min at 18-25 ℃, boiling with strong fire, decocting with slow fire for 20-30 min, and filtering to obtain filtrate for later use; adding water into the filter residue, boiling with strong fire, decocting with slow fire for 10-15 min, filtering, discarding the filter residue to obtain filtrate, mixing the two filtrates, and concentrating.

In the scheme, the method comprises the following steps: the water adding amount for the first decoction is 6-10 times of the total dosage, and the water adding amount for the second decoction is 3-4 times of the total dosage. The above amounts are all by mass.

In the scheme, the method comprises the following steps: concentrating to one third of the twice added water.

In the scheme, the method comprises the following steps: and adding medicinal or edible carrier or adjuvant, and making into oral liquid preparation or oral solid preparation. Adding carrier or adjuvant after concentrating, and making into oral liquid or oral solid preparation

In the scheme, the method comprises the following steps: the oral solid preparation is tablet, capsule, granule.

The invention selects the medicines for combination, and combines the medicines to generate synergistic effect on the efficacy of each medicine, thereby effectively treating the wind-phlegm obstruction type peripheral facial paralysis. All the medicinal materials are received in the 2020 edition of Chinese pharmacopoeia.

The invention has the advantages of low-cost and easily obtained raw materials, simple preparation method, low cost and good effect, is easy to take, can be used for treating facial nerve ischemia and hypoxia caused by wind-phlegm obstruction type peripheral facial paralysis and nerve paralysis caused by facial nerve compression, and is an innovation of medicines for treating wind-phlegm obstruction type peripheral facial paralysis.

The dosage and the course of treatment of the traditional Chinese medicine composition can be properly adjusted according to the dosage form, the age of a patient and the degree of severity of the disease, and the traditional Chinese medicine composition can be continuously used for a plurality of courses of treatment with 2 months as one course of treatment.

The traditional Chinese medicine composition for treating wind-phlegm obstruction type peripheral facial paralysis has the following characteristics of the individual medicines in 12 raw material medicines, namely the main medicines with the characteristics of meridian tropism, efficacy, main treatment symptoms, medical records and pharmacological actions:

The stiff silkworm is a whole worm body of Vuillant stiff row infected with beauveria bassiana Beauveria bassiana (Bals.) of the family Fabricius, the nature is salty, pungent and flat, and the stiff silkworm has the effects of dispelling wind and relieving spasm, and resolving phlegm and resolving masses, and is clinically used for treating tangible masses such as nodules, sore throat, scrofula, wind sore urticaria and the like. In Shennong Ben Cao Jing: "mainly infantile convulsion and night cry, remove three worms, kill black, make the complexion good, and male yin sore. "Ben Cao gang mu": "wind-phlegm-dispelling tuberculosis, scrofula, headache, wind-worm toothache, skin wind-sore, erysipelas itching, … … all sores, furuncle wind-hemorrhoids. Modern pharmacological research shows that batryticated silkworm mainly contains protein, fat, various amino acids and microelements such as iron, zinc, copper, manganese and chromium. The white powder on the body surface of the silkworm contains ammonium oxalate. Has sedative, hypnotic, anticonvulsant, anticoagulant, antitumor, and blood glucose lowering effects.

The scorpion is a dried body of Buthus martensii Karsch Buthus MARTENSII KARSCH of Buthus martensii Karsch, has the effects of calming endogenous wind and relieving spasm, eliminating toxin and resolving hard mass, and dredging collaterals and relieving pain, and is mainly used for treating infantile convulsion, convulsion and spasm, askew stroke mouth, hemiplegia, tetanus, wind-damp obstinate arthralgia, migraine, pyocutaneous disease and scrofula. In "Yuhua Yao Jie": "penetrate tendons and penetrate joints, remove dampness and wind. Modern pharmacological research shows that scorpion contains scorpion venom, enzyme and other active components. Has antiepileptic, anticonvulsant, analgesic, antitumor, antithrombotic, blood pressure lowering, and antibacterial effects.

The arisaema cum bile is prepared by processing arisaema tuber fine powder and cow, sheep or pig bile (Chinese pharmacopoeia), or is prepared by fermenting arisaema tuber fine powder and cow, sheep or pig bile, has bitter and cold taste, is cool, enters lung, liver and spleen meridians, has the effects of clearing fire and resolving phlegm, relieving convulsion and arresting epilepsy, and is used for treating apoplexy, convulsion and epilepsy, phlegm fire and asthma cough, dizziness and the like. In "Bencaozheng": "treating infantile acute convulsions, excessive phlegm and excessive fire obstructing upper energizer, dyspnea and dysphoria, thirst and distention and fullness". "Ben Cao Hui Yan": for infantile convulsions, convulsions of limbs, internal heat due to deficiency of qi and heat Yu Sheng phlegm. "Dannan xing has the actions of clearing heat and resolving phlegm, dannan xing is bitter and cool, bitter can dry dampness and resolve phlegm, and cold can clear heat, and can be used for treating symptoms such as phlegm-fire cough, dizziness, apoplexy, phlegm stagnation, senile mental retardation, postpartum severe palpitation, phlegm-fire insomnia and the like.

The ligusticum wallichii is rhizome of ligusticum wallichii Ligusticum chuanxiong Hort belonging to the family Umbelliferae, has pungent and warm nature, enters into liver and gall meridians, has the effects of activating blood circulation, promoting qi circulation, dispelling wind and relieving pain, and is used for irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain, thorny chest and hypochondrium pain, traumatic injury, headache, rheumatalgia and the like. In the book of changes: "mainly apoplexy involving brain headache, cold arthralgia, spasm of tendons, gold wound, and blood obstruction of women without son". "Ming Yi Bie Lu (Ming Yi Bie Lu)": the medicine is effective in removing cold in brain, removing wind from upstream face, removing tears, excessive nasal discharge and saliva, neglecting, such as drunk, cold qi, hard pain in heart and abdomen, aversion to middle-jiao, acute swelling and pain, hypochondriac pain, and warm middle-jiao and internal cold. "drug theory": for treating weakness of waist and feet, hemiplegia, primary dystonia, and cold pain in abdomen. Modern pharmacological research shows that chuanxiong rhizome contains chuanxiongzine, ligustilide, neoligustilide, etc. Has effects in relieving myocardial ischemia, improving blood rheology, relieving cerebral ischemia, relieving fever, and tranquilizing mind.

The radix sileris is root of a plant Saposhnikovia divaricata (Trucz.) of Fangfeng genus of Umbelliferae, has pungent and sweet nature and slightly warm nature, enters meridians of bladder, lung, spleen and liver, has the effects of sweating, eliminating phlegm, dispelling wind, relieving exterior syndrome and easing pain, and is used for treating symptoms such as cold, headache, joint pain of the whole body, neuralgia and the like. In the book of changes: the main wind is dizzy and painful, aversion to wind, pathogenic wind, blindness, general wind, arthralgia and restlessness. "Ming Yi Bie Lu (Ming Yi Bie Lu)": hypochondriac pain, hypochondriac wind-head and face removal, limb spasm, internal spasm of the sore with mammary gland. "Ben Cao Jing Shu": the Chinese medicinal composition is suitable for wind prevention and treatment, and can be used for ascending and dispersing, so that the Chinese medicinal composition is mainly used for treating dizziness and pain, aversion to wind evil, bone and joint pain arthralgia, hypochondriac pain and hypochondriac pain on the face of the head. Modern pharmacological studies have shown that ledebouriella root contains components such as sapogenol, cimicifuga rhizome glycoside, etc. Has effects in relieving fever, tranquilizing, relieving pain, relieving convulsion, and resisting allergy.

The Curcuma aromatica is dried root tuber of Curcuma aromatica Curcuma rcenyujin Y.H.Chen et C.Ling, curcuma longa L, curcuma zedoaria Curcumakwangsiensis S.G.Lee et C.F.Liang or Curcuma zedoaria Curcuma phaeocaulis Val. Drug Property theory describes: for female with blood, qi and heart pain, cold and accumulation, wen Cuma is taken. "Ben Cao gang mu": for postpartum septicemia, heart-flushing, and crazy, it is indicated for heart failure and vesania. Modern pharmacological research shows that curcuma root contains curcumin, demethoxycurcumin, curcumene and other components. Has effects in protecting liver, reducing blood viscosity, and inhibiting platelet aggregation.

The Poria cocos disclosed by the invention is sclerotium of Polyporaceae fungus Poria cocos (Schw) Wolf, has sweet, light and flat taste, is nontoxic, and has the effects of excreting dampness and promoting diuresis, tonifying spleen and stomach and kidney, soothing nerves and promoting fluid production and the like, and is used for quenching thirst, promoting urination, dehumidifying and tonifying dryness, and regulating middle warmer and tonifying qi. In the book of changes: "chest and hypochondrium adverse qi, frightening frightening evil, palpitation, pain in heart and lower extremities, dysphoria with smothery sensation, fullness and dysphoria, cough and adverse qi, mouth Jiao Shegan, and urination. Is taken for a long time, and has the effects of tranquilizing mind, allaying hunger and prolonging life. Modern pharmacological research shows that poria cocos has the effects of regulating immunity, promoting urination, resolving stone, protecting liver, resisting leukemia, resisting tumor, resisting fatigue, resisting aging and the like.

The tuber fleeceflower stem is the rattan stem or rattan stem with leaves of polygonum multiflorum Polygonum multi florum Thunb of the polygonaceae, has sweet nature and taste, is calm, enters heart and liver channels, has the effects of nourishing heart and soothing nerves, dredging collaterals and dispelling wind and the like, and is used for insomnia, fatigue, hyperhidrosis, blood deficiency body pain, carbuncle, scrofula, wind sore and scabies and the like. In "materia medica regeneration": bitter taste, warm nature and no toxicity. Modern pharmacological research shows that tuber fleeceflower stem contains emodin, chrysophanol, luteolin-5-O-xyloside and other components. Has effects in reducing blood lipid, preventing and treating atherosclerosis, tranquilizing mind, and hypnotizing.

The polygala tenuifolia is the dried root of polygala tenuifolia Polygala tenuifolia Willd, which is a polygala tenuifolia family plant, has bitter, pungent and warm nature, enters heart, kidney and lung channels, has the effects of soothing nerves, improving intelligence, eliminating phlegm and detumescence, and is used for insomnia and dreaminess, amnesia and palpitation, tranquility, expectoration, unsmooth phlegm, pyocutaneous disease swelling and toxin, breast swelling and the like caused by heart-kidney imbalance. In the book of changes: in the cough and adverse flow of qi, the main cough is deficient in tonifying, removing pathogenic factors, inducing nine orifices, benefiting wisdom, improving hearing and hearing, not forgetting, and strengthening the strength. "Ming Yi Bie Lu (Ming Yi Bie Lu)": "centering Qi, stopping palpitation, replenishing essence, removing diaphragmatic Qi of heart and skin heat and yellow complexion". "drug theory": "treating heart-mind and strengthening spring, strengthening yang and channel. The main dream evil. Modern pharmacological research shows that polygala tenuifolia contains polygala tenuifolia sapogenin A, polygala tenuifolia sapogenin B, polygala tenuifolia tut-tut ketone III and other components. Has sedative and hypnotic effects, and is effective in relieving convulsion, eliminating phlegm, and resisting aging.

The astragalus membranaceus is the root of astragalus membranaceus Astragalus membranaceus (Fisch.) bge. Var. Mongholicus (bge.) Hsiao or astragalus membranaceus Astragalus membranaceus (Fisch.) bge. Of Leguminosae, has sweet taste and slight temperature, is used for restoring menstrual flow, and has the effects of tonifying qi, consolidating exterior, promoting urination, strengthening heart, reducing blood pressure, resisting bacteria, expelling toxin, promoting pus, promoting granulation and the like, and is used for treating spontaneous perspiration due to exterior deficiency, internal injury due to qi deficiency, diarrhea due to spleen deficiency, edema, carbuncle and the like. Modern pharmacological studies show that astragalus contains astragalus saponin I, II, III, IV and other components. Has effects in enhancing immunity, promoting hematopoiesis, delaying aging, lowering blood sugar, lowering blood pressure, and reducing blood lipid.

The tangerine peel is ripe peel of rutaceae plant tangerine Citrus reticulata Blanco and cultivated varieties thereof. The dried orange peel has warm, pungent and bitter taste and is good for spleen, stomach and lung meridians, and has the effects of regulating qi, strengthening spleen, regulating middle warmer, drying dampness and resolving phlegm. Can be used for treating abdominal distention, pain, and dyspepsia due to qi stagnation of spleen and stomach. Chest distress, abdominal distention, anorexia and loose stool due to damp-turbidity obstruction. Cough and asthma due to phlegm-dampness obstructing the lung. Can be used for treating fullness in chest and epigastrium, anorexia, vomiting and diarrhea, cough with excessive phlegm, etc. In Ben Cao gang mu: the' its qi-regulating and dampness-drying actions are taken until the time of its hundred, and the same tonic and laxative are used for tonifying, the same ascending and descending are used for descending. Spleen is the mother of primordial qi, lung is the requirement of qi-taking, so orange peel is the requirement of qi-dividing of two meridians, but it is also accompanied by the ascending and descending of reinforcing and reducing. "in daily herbal: "can dispel energy and purge, warm energy and tonify, can dispel diaphragmatic qi, resolve phlegm and saliva, harmonize spleen and relieve cough, and treat five stranguria. Modern pharmacological research shows that orange peel contains hesperidin, nobiletin, neohesperidin and other components. Has effects in regulating gastrointestinal motility, relieving allergy, relieving asthma, resisting tumor, eliminating phlegm, and reducing serum cholesterol.

The liquorice provided by the invention is dry roots and rhizomes of liquorice Glycyrrhiza uralensis Fisch, liquorice Glycyrrhiza inflata Bat or liquorice Glycyrrhiza glabra L which are leguminous plants, has sweet and flat taste, is used for heart, lung, spleen and stomach channels, has the effects of invigorating spleen and replenishing qi, nourishing cough and moistening lung, relieving urgency and detoxification, harmonizing medicines and the like, and is used for sore throat, carbuncle and sore, gastrointestinal ulcer, drug toxicity relieving, food poisoning and the like. In Ming Yi Bie Lu: warming middle-jiao and descending qi, relieving restlessness and shortness of breath, injuring viscera and relieving cough, quenching thirst, dredging channels and collaterals, li Xieqi and relieving hundred medicine toxins. "drug theory": cold pain in the main abdomen, treating convulsive epilepsy and removing abdominal distention and fullness; tonify five viscera; preparing various drug toxins; nourishing kidney-qi and relieving internal injury, causing yin (not) flaccidity; housewives experience lower back pain; deficiency and excessive heat; and is used in addition. Modern pharmacological studies show that licorice contains glycyrrhizin, glycyrrhizic acid, glycyrrhizin and other components. Has effects in resisting peptic ulcer, inhibiting bacteria, removing toxic substances, and inhibiting contraction of uterine smooth muscle.

The exogenous cause of this disease is wind. Wind is a long disease and is easy to get other diseases. "Ling Shu-Jing Jin" cloud: the patient can lead to acute cheek movement when the cheek tendon of … … is cold, and can lead to slow and non-superior tendon movement when the cheek tendon is hot. The cold and heat evil is considered to easily invade the facial meridians as a disease. The cause of this disease is deficiency. "Su-Wen-Ji-fei-Bing Lun (plain question and evaluation of fever theory of diseases)": the pathogenic qi is deficient due to the accumulation of pathogenic factors. The pathogenesis of wind-phlegm obstruction of collaterals and remote mouth is that pathogenic wind-cold invades the face channels and collaterals, mainly relates to the yangming channels and collaterals. "Ling Shu-Jing Jin" cloud: the yang of the foot, the rapid movement of the hand, the rapid movement of the tendons and eyes, the acute movement of the canthus, and the inability to stroke. The treatment mainly comprises dispelling wind and resolving phlegm, and tonifying qi and nourishing blood.

The stiff silkworm has the effects of dispelling wind and dredging collaterals, reducing phlegm, and the scorpion has the effects of calming endogenous wind and relieving spasm, and dredging collaterals and relieving pain, and is a monarch drug. Arisaema cum bile has the functions of clearing heat and resolving phlegm, calming endogenous wind and arresting convulsion. Ligusticum wallichii has the effects of promoting blood circulation and activating qi-flowing, dispelling wind and relieving pain, and radix sileris has the effects of dispelling wind and eliminating dampness and relieving pain and spasm, and radix curcumae has the effects of promoting blood circulation and relieving pain and activating qi-flowing as ministerial drugs. Poria cocos has the effects of promoting diuresis and removing dampness, tuber fleeceflower stem has the effects of dispelling wind and dredging collaterals, radix polygalae has the effects of eliminating phlegm and detumescence, radix astragali has the effects of promoting diuresis and detumescence, promoting stagnancy and relieving arthralgia, and pericarpium citri reticulatae has the effects of regulating qi, eliminating dampness and resolving phlegm as adjuvant drugs. Licorice root, radix Glycyrrhizae regulates the action of other drugs and acts as a guiding drug. Because wind-damp herbs are pungent and dry, they are used to nourish blood, activate blood and remove meridian obstruction, so they are in line with the meaning of treating wind first and blood going out of wind and restrict the dryness of wind-damp herbs. The whole formula has the effects of dispelling wind and resolving phlegm, and also has the effects of replenishing blood, promoting blood circulation and nourishing yin, so as to treat facial paralysis caused by wind-phlegm obstruction of collaterals. Clinically, the treatment can be modified according to the actual conditions.

The invention has complementary advantages of all the medicines, and the medicines are combined to fully play the synergistic effect of all the medicines, so that the product can be used for treating peripheral facial paralysis caused by obstruction of wind-phlegm by multiple ways under the combined action of multiple active ingredients.

Detailed Description

The invention is further described below with reference to examples.

Example 1

The traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 100 parts of stiff silkworm, 60 parts of scorpion, 100 parts of arisaema cum bile, 50 parts of ligusticum wallichii, 70 parts of radix sileris, 100 parts of radix curcumae, 110 parts of poria cocos, 140 parts of tuber fleeceflower stem, 110 parts of polygala tenuifolia, 120 parts of astragalus membranaceus, 100 parts of dried orange peel and 40 parts of liquorice. Wherein, all the raw materials are added with water for 10 times, soaked for 15-25 min at 18-25 ℃, then boiled with strong fire, decocted with slow fire for 20-30 min, and filtered to obtain filtrate for standby; adding water into the filter residue for 3 times, boiling with strong fire, decocting with slow fire for 10-15 min, filtering, discarding the filter residue to obtain filtrate, mixing the two filtrates, and concentrating to one third of the water content. Adding appropriate amount of adjuvants, mixing, granulating with boiling granulating equipment, and tabletting.

Example 2

The traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 110 parts of stiff silkworm, 70 parts of scorpion, 110 parts of arisaema cum bile, 50 parts of ligusticum wallichii, 80 parts of radix sileris, 120 parts of radix curcumae, 130 parts of poria cocos, 160 parts of tuber fleeceflower stem, 120 parts of polygala tenuifolia, 120 parts of astragalus membranaceus, 110 parts of dried orange peel and 50 parts of liquorice. Adding water 6 times of all the raw materials, soaking for 15-25 min at 18-25 ℃, boiling with strong fire, decocting with slow fire for 20-30 min, and filtering to obtain filtrate for later use; adding water into the filter residue for 4 times, boiling with strong fire, decocting with slow fire for 10-15 min, filtering, discarding the filter residue to obtain filtrate, mixing the two filtrates, and concentrating to one third of the water content. Adding appropriate amount of adjuvant, mixing, granulating with boiling granulating equipment, and making into capsule.

Example 3

The traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 120 parts of stiff silkworm, 70 parts of scorpion, 130 parts of arisaema cum bile, 60 parts of ligusticum wallichii, 80 parts of radix sileris, 120 parts of radix curcumae, 130 parts of poria cocos, 170 parts of tuber fleeceflower stem, 130 parts of polygala tenuifolia, 130 parts of astragalus membranaceus, 120 parts of dried orange peel and 50 parts of liquorice. Adding 8 times of water into all the raw materials, soaking for 15-25 min at 18-25 ℃, boiling with strong fire, decocting with slow fire for 20-30 min, and filtering to obtain filtrate for later use; adding water into the filter residue for 3 times, boiling with strong fire, decocting with slow fire for 10-15 min, filtering, discarding the filter residue to obtain filtrate, mixing the two filtrates, and concentrating to one third of the water content. The boiling granulation equipment is adopted, and a proper amount of auxiliary materials are added to prepare the granules.

Example 4

The traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 90 parts of stiff silkworm, 40 parts of scorpion, 90 parts of arisaema cum bile, 40 parts of ligusticum wallichii, 60 parts of radix sileris, 90 parts of radix curcumae, 90 parts of poria cocos, 140 parts of tuber fleeceflower stem, 90 parts of polygala tenuifolia, 90 parts of astragalus membranaceus, 90 parts of dried orange peel and 30 parts of liquorice. Adding water 10 times of all the raw materials, soaking for 15-25 min at 18-25 ℃, boiling with strong fire, decocting with slow fire for 20-30 min, and filtering to obtain filtrate for later use; adding water into the filter residue for 3 times, boiling with strong fire, decocting with slow fire for 10-15 min, filtering, discarding the filter residue to obtain filtrate, mixing the two filtrates, and concentrating to one third of the water content. Granulating with boiling granulating equipment, and tabletting with tablet press.

Example 5

The traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 140 parts of stiff silkworm, 80 parts of scorpion, 140 parts of arisaema cum bile, 80 parts of ligusticum wallichii, 80 parts of radix sileris, 100 parts of radix curcumae, 150 parts of poria cocos, 180 parts of tuber fleeceflower stem, 120 parts of polygala tenuifolia, 100 parts of astragalus membranaceus, 140 parts of dried orange peel and 60 parts of liquorice. Adding water 10 times of all the raw materials, soaking for 15-25 min at 18-25 ℃, boiling with strong fire, decocting with slow fire for 20-30 min, and filtering to obtain filtrate for later use; adding water into the filter residue for 3 times, boiling with strong fire, decocting with slow fire for 10-15 min, filtering, discarding the filter residue to obtain filtrate, mixing the two filtrates, and concentrating to one third of the water content. Granulating with boiling granulating equipment, and tabletting with tablet press.

The beneficial effects of the invention are further illustrated by the following test examples:

clinical efficacy evaluation of wind-phlegm obstruction of collaterals type peripheral facial paralysis patient

84 Patients with wind-phlegm obstruction type peripheral facial paralysis are selected, the ages are 20-56, and the disease course is 2-7 days. The treatment method comprises randomly dividing into 4 groups, namely an example 1 group, an example 2 group, an example 3 group and a western medicine control group, wherein 21 cases of each group are respectively provided with 11 men and 10 women, and the cases of each group have no significant difference in symptoms, gender, age, disease course and the like.

Western diagnostic criteria

Meets the diagnosis standard of idiopathic facial palsy in neurology, namely, facial paralysis, loss of forehead lines, facial distortion and air leakage during whistle.

Diagnostic criteria for traditional Chinese medicine

Meets the diagnosis standard of the apoplexy phlegm obstruction collaterals type remote mouth disease in the diagnosis curative effect standard of the traditional Chinese medicine syndrome, and has facial distortion and abnormal feeling.

Inclusion criteria

Meets the diagnostic criteria; unilateral onset; age 18-70 years; the course of the disease is 2 to 7 days; intolerance to acupuncture and moxibustion; voluntarily receives the present treatment regimen.

Exclusion criteria

Central facial paralysis; patients with severe gravity center, brain, kidney, etc.; mental patients; gestational and lactating patients; allergic patients.

Therapeutic method

Examples 1-3 Chinese medicinal composition treatment groups: each group of 21 patients, 63 patients, were respectively decocted with water 3 times a day to obtain 300mL decoction, which was taken 3 times a day with the Chinese medicinal composition described in examples 1-3 of the present invention. Treatment 14d.

Western medicine control group: in 21 patients, prednisone acetate tablet (5 mg/tablet) is taken in the morning, 30mg daily, and 5mg is decreased daily after 5d until the administration is stopped; mecobalamin tablets (0.5 mg/tablet) are orally taken, 0.5mg daily, 3 times daily; thrombus (250 mg/branch) for injection was added to 200mL of a 0.9% sodium chloride injection by intravenous drip 1 time a day. Treatment 14d.

Efficacy evaluation criteria

(1) Facial nerve function. The degree of illness before and after treatment was compared using House-Brackmann facial nerve function (H-B) scale. (2) clinical efficacy. Two groups of clinical efficacy were observed with reference to the H-B scale. ① heals: the clinical symptoms and physical signs completely disappear, no facial distortion exists during actions such as laughing and the like, the expression is recovered to be normal, and the nerve function of the H-B surface is graded to be grade I; ② shows effect: clinical symptoms and physical signs largely disappear, the expression is basically normal when the patient is at rest, but the expression action still has slight skew when the emotion is excited, and the H-B facial nerve function is graded to be II grade; ③ is effective: the clinical symptoms and the physical sign part disappear, the symptoms are obviously askew when the emotion is excited, and the H-B surface nerve function is graded to be III grade; ④ null: the clinical symptoms and physical signs are not improved, and the H-B surface nerve function is graded to IV grade or above.

Total effective rate= (cure + effect + effective) number of cases/total number of cases x 100%.

Results

1. Clinical efficacy comparison: the total effective rates of the traditional Chinese medicine compositions in the embodiment 1, the embodiment 2 and the embodiment 3 for treating the wind-phlegm obstruction type facial paralysis are respectively 90.5%, 95.2% and 90.5%, the total effective rates of the positive control western medicine treatment are respectively 71.4%, the curative effect of the traditional Chinese medicine composition groups in the embodiment 1-3 is obviously superior to that of the western medicine control group, and the difference has statistical significance (P is less than 0.05), and the table is shown in the table 1.

2. Facial nerve function improvement comparison: there was no statistical difference in the H-B grade comparisons of the groups prior to treatment. After treatment, the patients (grade of H-B surface nerve function is classified into grade I) cured by the traditional Chinese medicine composition treatment groups of the embodiment 1, the embodiment 2 and the embodiment 3 are respectively 7, 8 and 6, the patients (grade of H-B surface nerve function is classified into grade II) cured by the traditional Chinese medicine composition treatment groups of the embodiment 1, the embodiment 2 and the embodiment 3 are respectively 9, 10 and 11, the patients cured by the positive control western medicine treatment groups and the patients cured by the effective treatment groups are only 3 and 6, the improvement condition of the nerve function after the treatment of the traditional Chinese medicine composition treatment groups of the embodiment 1 to 3 is obviously superior to that of the positive control western medicine treatment, and the difference has statistical significance (P is less than 0.05), and the statistical significance is shown in the table 1.

3. Toxic and side effects: the traditional Chinese medicine composition treatment groups and the western medicine control treatment group in examples 1-3 have no obvious adverse reaction and obvious toxic and side effects before and after the treatment of the cases.

Surface.1 treatment of peripheral facial paralysis patient before and after treatment

Note that: compared with western medicine control treatment group, ^* P is less than 0.05

The clinical research results of the traditional Chinese medicine composition for treating wind-phlegm obstruction type peripheral facial paralysis show that the traditional Chinese medicine composition for treating wind-phlegm obstruction type peripheral facial paralysis has reasonable formula compatibility, has the effects of eliminating phlegm and dredging collaterals, can remarkably improve the treatment effect on wind-phlegm obstruction type peripheral facial paralysis and improve the facial nerve function of patients, and has good safety tolerance.

Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The composition for treating wind-phlegm obstruction type peripheral facial paralysis is characterized by being prepared from the following raw materials in parts by weight: 90-140 parts of stiff silkworm, 40-80 parts of scorpion, 90-140 parts of arisaema cum bile, 40-80 parts of ligusticum wallichii, 60-100 parts of radix sileris, 90-140 parts of radix curcumae, 100-150 parts of poria cocos, 120-180 parts of tuber fleeceflower stem, 90-140 parts of polygala tenuifolia, 90-140 parts of astragalus membranaceus, 90-140 parts of dried orange peel and 30-60 parts of liquorice;

The preparation method comprises the following steps: adding water into the raw materials, soaking for 15-25 min at 18-25 ℃, boiling with strong fire, decocting with slow fire for 20-30 min, and filtering to obtain filtrate for later use; adding water into the filter residue, boiling with strong fire, decocting with slow fire for 10-15 min, filtering, discarding the filter residue to obtain filtrate, mixing the two filtrates, and concentrating.

2. The composition for treating wind-phlegm obstruction type peripheral facial paralysis according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 100 parts of stiff silkworm, 60 parts of scorpion, 100 parts of arisaema cum bile, 50 parts of ligusticum wallichii, 70 parts of radix sileris, 100 parts of radix curcumae, 110 parts of poria cocos, 140 parts of tuber fleeceflower stem, 110 parts of polygala tenuifolia, 120 parts of astragalus membranaceus, 100 parts of dried orange peel and 40 parts of liquorice.

3. The composition for treating wind-phlegm obstruction type peripheral facial paralysis according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 110 parts of stiff silkworm, 70 parts of scorpion, 110 parts of arisaema cum bile, 50 parts of ligusticum wallichii, 80 parts of radix sileris, 120 parts of radix curcumae, 130 parts of poria cocos, 160 parts of tuber fleeceflower stem, 120 parts of polygala tenuifolia, 120 parts of astragalus membranaceus, 110 parts of dried orange peel and 50 parts of liquorice.

4. The composition for treating wind-phlegm obstruction type peripheral facial paralysis according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 120 parts of stiff silkworm, 70 parts of scorpion, 130 parts of arisaema cum bile, 60 parts of ligusticum wallichii, 80 parts of radix sileris, 120 parts of radix curcumae, 130 parts of poria cocos, 170 parts of tuber fleeceflower stem, 130 parts of polygala tenuifolia, 130 parts of astragalus membranaceus, 120 parts of dried orange peel and 50 parts of liquorice.

5. The composition for treating wind-phlegm obstruction type peripheral facial paralysis according to claim 4, wherein: the water adding amount for the first decoction is 6-10 times of the total dosage, and the water adding amount for the second decoction is 3-4 times of the total dosage.

6. The composition for treating wind-phlegm obstruction type peripheral facial paralysis according to claim 5, wherein: concentrating to one third of the twice added water.

7. The composition for treating wind-phlegm obstruction type peripheral facial paralysis according to claim 6, wherein: and adding medicinal or edible carrier or adjuvant, and making into oral liquid preparation or oral solid preparation.

8. The composition for treating wind-phlegm obstruction type peripheral facial paralysis according to claim 7, wherein: the oral solid preparation is tablet, capsule, granule.