CN107753584B - Chinese ephedra anti-allergic traditional Chinese medicine composition and preparation method thereof - Google Patents
Chinese ephedra anti-allergic traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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- CN107753584B CN107753584B CN201711249671.1A CN201711249671A CN107753584B CN 107753584 B CN107753584 B CN 107753584B CN 201711249671 A CN201711249671 A CN 201711249671A CN 107753584 B CN107753584 B CN 107753584B
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention relates to the field of traditional Chinese medicines, in particular to an anti-allergic traditional Chinese medicine composition containing ephedra and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-30 parts of ephedra, 10-15 parts of cocklebur fruit, 10-15 parts of divaricate saposhnikovia root, 8-15 parts of perilla leaf, 10-15 parts of bighead atractylodes rhizome, 5-15 parts of cassia twig, 5-15 parts of white paeony root and 5-10 parts of liquorice. The invention effectively exerts the medicinal effects of the ephedra herb and the like through reasonable compatibility of various traditional Chinese medicines, prepares the ephedra herb antiallergic granule, effectively treats allergic rhinitis, and has simple process, wide application range and no toxic or side effect.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to an anti-allergic traditional Chinese medicine composition containing ephedra and a preparation method thereof.
Background
Allergic diseases mainly include: eczema, allergic dermatitis, allergic conjunctivitis, allergic enteritis, allergic rhinitis, allergic asthma (asthma for short), etc. These allergic diseases may exist alone or in combination with each other to cause multi-system allergy. Many epidemiological investigations have confirmed that the incidence of allergic diseases has been rising worldwide in recent years, and has become a very compelling social problem, among which the highest rising rate is allergic asthma and allergic rhinitis. Not only brings inconvenience to daily life, causes mental pain and reduces the quality of life, but also has long duration, some become intractable symptoms and cause death.
The herba Ephedrae is dried stem of Ephedra sinica (Ephedra sinicatapf), Ephedra intermedia (Ephedra intermedia SchrenktC.A.Mey.) or Ephedra equisetifolia (Ephedra equitina Bge.) of Ephedraceae. Ephedra has a long medicinal history in China, and all doctors of all ages use the ephedra as a medicine for inducing sweat, relieving exterior syndrome, ventilating lung, relieving asthma, inducing diuresis and reducing edema. Wherein the alkaloid components are considered as the effective components of ephedra for relieving asthma, and the components have the sympathetic nerve excitation effect similar to adrenalin. In recent years, with the intensive research on ephedra, there have been increasing reports on the pharmacological actions of non-alkaloid components of ephedra. Researches show that the non-alkaloid components in the ephedra have pharmacological effects of reducing blood pressure, reducing blood sugar, resisting oxidation, resisting coagulation, inhibiting immunity and the like. The non-alkaloid component of the glufosinate in the ephedra stem has stronger activity of stimulating GPR35 receptor, which provides a new idea for further developing and utilizing ephedra stem resources.
Disclosure of Invention
The invention aims to provide an ephedra anti-allergic traditional Chinese medicine composition and a preparation method thereof.
The purpose of the invention is realized by the following technical scheme:
an anti-allergic Chinese ephedra traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 20-30 parts of ephedra, 10-15 parts of cocklebur fruit, 10-15 parts of divaricate saposhnikovia root, 8-15 parts of perilla leaf, 10-15 parts of bighead atractylodes rhizome, 5-15 parts of cassia twig, 5-15 parts of white paeony root and 5-10 parts of liquorice.
Further, the ephedra anti-allergic traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 26 parts of ephedra, 12 parts of cocklebur fruit, 12 parts of divaricate saposhnikovia root, 9 parts of perilla leaf, 12 parts of largehead atractylodes rhizome, 6 parts of cassia twig, 5 parts of white paeony root and 6 parts of liquorice.
The formulation of the ephedra anti-allergy traditional Chinese medicine composition is granules.
The preparation method of the ephedra antiallergic traditional Chinese medicine composition comprises the following steps:
(1) rinsing and airing ephedra, cocklebur fruit, divaricate saposhnikovia root, perilla leaf, bighead atractylodes rhizome, cassia twig, white paeony root and liquorice according to the proportion to obtain a raw material mixture;
(2) decocting the raw material mixture in water for 3 times, each time for 1.5 hr, mixing decoctions, and filtering to obtain filtrate;
(3) concentrating the filtrate under reduced pressure to obtain soft extract, and drying to obtain extract;
(4) adding adjuvants into the extract, mixing, and granulating with a swing type granulator to obtain herba Ephedrae antiallergic granule.
Further, the preparation method of the ephedra anti-allergy Chinese medicinal composition comprises the step (2) of adding 10 times of water by mass of the raw material mixture for the first time, adding 8 times of water by mass of the raw material mixture for the second time and adding 8 times of water by mass of the raw material mixture for the third time during decoction.
Further, the preparation method of the ephedra anti-allergy traditional Chinese medicine composition is characterized in that the filtrate is concentrated to the specific gravity of 1.0-1.2 or to 25-30% of the total mass of the filtrate.
Further, the preparation method of the ephedra antiallergic traditional Chinese medicine composition is characterized in that the drying is spray drying, the inlet temperature of the spray drying is 130-180 ℃, and the outlet temperature of the spray drying is 85-105 ℃.
Further, in the preparation method of the ephedra anti-allergic traditional Chinese medicine composition, the amount of the added auxiliary materials is 1-2 times of the mass of the extract; the added auxiliary materials are a mixture of lactose, soluble starch and dextrin according to the mass ratio of 2:1: 3.
Further, according to the preparation method of the ephedra anti-allergy traditional Chinese medicine composition, a lubricant, namely magnesium lauryl sulfate, is added when a swing type granulator is used for granulation, and the amount of the added lubricant is 1% -2% of the total mass of the extract and the auxiliary materials.
The ephedra anti-allergic traditional Chinese medicine composition is applied to the medicine for treating allergic rhinitis.
In the invention, the effects of the traditional Chinese medicine raw materials are as follows:
fructus xanthil: has the effects of dispersing wind-cold, relieving stuffy nose, dispelling wind-damp and relieving pain, and can be used for treating wind-cold type common cold, nasosinusitis, rheumatalgia, rubella spasm and itching, etc.
Wind prevention: alias names copper rue, Huiyun, Hui grass, Baizhi and Bai species. Pungent and sweet in flavor, slightly warm in nature. Has the effects of dispelling pathogenic wind, relieving exterior syndrome, eliminating dampness, relieving pain, and relieving spasm.
Perilla leaf: pungent, mild and non-toxic. Relieving exterior syndrome, dispelling cold, regulating qi-flowing, harmonizing ying. It can be used for treating common cold, wind-cold, aversion to cold, fever, cough, headache, no sweat, asthma, fullness and distention of chest and abdomen, nausea and diarrhea, obstruction of pharynx, pernicious vomiting, and threatened abortion.
Bai Zhu is bitter and sweet in property and warm in nature. It enters spleen and stomach meridians. The functions are mainly used for strengthening spleen and replenishing qi, eliminating dampness and promoting diuresis, suppressing sweating and preventing miscarriage. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion.
Gui Zhi, pungent and sweet in flavor and warm in nature. It enters heart, lung and bladder meridians. Has the effects of inducing sweat, expelling pathogenic factors from muscles, warming channels, activating collaterals, supporting yang, regulating qi, dispelling cold, and relieving pain.
White peony root, radix Paeoniae alba, with cold nature, bitter and sour taste, slightly cold, has effects of enriching blood and nourishing liver, calming liver and relieving pain, astringing yin and astringing sweat, etc.
Licorice root, radix Glycyrrhizae is light in smell and sweet and special in taste. The functions are mainly used for clearing away heat and toxic material, eliminating phlegm and relieving cough, and treating abdominal cavity and the like.
Compared with the prior art, the invention has the following beneficial effects:
1. the lung governs the skin and hair, which is the fence of the human body, and the exterior deficiency is susceptible to attack by exogenous pathogenic factors. The ephedra herb has the effects of releasing exterior and freeing lung, the perilla leaf has the effects of sweating and releasing exterior, the xanthium fruit has the effects of dispersing wind-cold and dispersing spleen-lung qi stagnation, the xanthium fruit has the effects of dispersing wind-cold and relieving stuffy nose, the divaricate saposhnikovia root has the effects of dispelling wind and eliminating dampness, the cassia twig has the effects of relieving muscles and exterior syndrome and supporting yang and regulating qi, and the four medicines have the effects of dispelling cold and releasing exterior. Bighead atractylodes rhizome, rhizoma Atractylodis Macrocephalae, invigorating the spleen and replenishing qi, white peony root, radix Paeoniae alba, nourishing blood and astringing yin, the two herbs harmonize qi and blood to eliminate diseases caused by exuberant qi and blood. The liquorice coordinates the various medicines to harmonize cold and heat, and the liquorice ascends and descends orderly. The invention effectively exerts the medicinal effects of the ephedra herb and the like through reasonable compatibility of various traditional Chinese medicines, prepares the ephedra herb antiallergic granule, effectively treats allergic rhinitis, and has simple process, wide application range and no toxic or side effect.
2. The invention is prepared into granules, the traditional Chinese medicine is fully decocted and extracted, and the carrying and the use are convenient.
Detailed Description
The present invention is further illustrated by the following specific examples.
Example 1
An ephedra antiallergic granule comprises the following raw material components in parts by weight: 20 parts of ephedra, 10 parts of cocklebur fruit, 11 parts of divaricate saposhnikovia root, 8 parts of perilla leaf, 13 parts of largehead atractylodes rhizome, 5 parts of cassia twig, 9 parts of white paeony root and 7 parts of liquorice.
The preparation method of the ephedra antiallergic granule comprises the following steps:
(1) weighing 20 parts of ephedra, 10 parts of cocklebur fruit, 11 parts of divaricate saposhnikovia root, 8 parts of perilla leaf, 13 parts of bighead atractylodes rhizome, 5 parts of cassia twig, 9 parts of white paeony root and 7 parts of liquorice, rinsing and airing to obtain a raw material mixture;
(2) decocting the raw material mixture obtained in the step (1) with water for 3 times, adding 10 times of water by mass for the first time, adding 8 times of water by mass for the second time, adding 8 times of water by mass for the third time, decocting for 1.5h each time, combining the decoction, and filtering to obtain a filtrate;
(3) concentrating the filtrate under reduced pressure to obtain soft extract with specific gravity of 1.0, spray drying at inlet temperature of 130 deg.C and outlet temperature of 85 deg.C to obtain extract,
(4) adding 20 parts of lactose, 10 parts of soluble starch and 30 parts of dextrin into the extract, and uniformly mixing; lubricating 1 part of lauryl magnesium sulfate, and granulating with a swing granulator to obtain the herba ephedrae antiallergic granule.
Example 2
An ephedra antiallergic granule comprises the following raw material components in parts by weight: 20 parts of ephedra, 10 parts of cocklebur fruit, 11 parts of divaricate saposhnikovia root, 8 parts of perilla leaf, 11 parts of largehead atractylodes rhizome, 5 parts of cassia twig, 10 parts of white paeony root and 5 parts of liquorice.
The preparation method of the ephedra antiallergic granule comprises the following steps:
(1) weighing 20 parts of ephedra, 10 parts of cocklebur fruit, 11 parts of divaricate saposhnikovia root, 8 parts of perilla leaf, 11 parts of bighead atractylodes rhizome, 5 parts of cassia twig, 10 parts of white paeony root and 5 parts of liquorice, rinsing and airing to obtain a raw material mixture;
(2) decocting the raw material mixture obtained in the step (1) with water for 3 times, adding 10 times of water by mass for the first time, adding 8 times of water by mass for the second time, adding 8 times of water by mass for the third time, decocting for 1.5h each time, combining the decoction, and filtering to obtain a filtrate;
(3) concentrating the filtrate under reduced pressure to obtain soft extract with specific gravity of 1.0, spray drying at inlet temperature of 130 deg.C and outlet temperature of 85 deg.C to obtain extract,
(4) adding 22 parts of lactose, 11 parts of soluble starch and 33 parts of dextrin into the extract, and uniformly mixing; lubricating 2 parts of lauryl magnesium sulfate, and then granulating by using a swinging granulator to obtain the ephedra antiallergic granule.
Example 3
An ephedra antiallergic granule comprises the following raw material components in parts by weight: 26 parts of ephedra, 12 parts of cocklebur fruit, 12 parts of divaricate saposhnikovia root, 9 parts of perilla leaf, 12 parts of largehead atractylodes rhizome, 6 parts of cassia twig, 5 parts of white paeony root and 6 parts of liquorice.
The preparation method of the ephedra antiallergic granule comprises the following steps:
(1) according to the weight parts, the composition of 26 parts of ephedra herb, 12 parts of cocklebur fruit, 12 parts of divaricate saposhnikovia root, 9 parts of perilla leaf, 12 parts of largehead atractylodes rhizome, 6 parts of cassia twig, 5 parts of white paeony root and 6 parts of liquoric root is rinsed and dried to obtain a raw material mixture;
(2) decocting the raw material mixture obtained in the step (1) with water for 3 times, adding 10 times of water by mass for the first time, adding 8 times of water by mass for the second time, adding 8 times of water by mass for the third time, decocting for 1.5h each time, combining the decoction, and filtering to obtain a filtrate;
(3) concentrating the filtrate under reduced pressure to obtain soft extract with specific gravity of 1.0, spray drying at inlet temperature of 130 deg.C and outlet temperature of 85 deg.C to obtain extract,
(4) adding 24 parts of lactose, 12 parts of soluble starch and 36 parts of dextrin into the extract, and uniformly mixing; lubricating 1 part of lauryl magnesium sulfate, and granulating with a swing granulator to obtain the herba ephedrae antiallergic granule.
Example 4
An ephedra antiallergic granule comprises the following raw material components in parts by weight: 26 parts of ephedra, 12 parts of cocklebur fruit, 12 parts of divaricate saposhnikovia root, 9 parts of perilla leaf, 13 parts of largehead atractylodes rhizome, 8 parts of cassia twig, 6 parts of white paeony root and 8 parts of liquorice.
The preparation method of the ephedra antiallergic granule comprises the following steps:
(1) weighing 26 parts of ephedra, 12 parts of cocklebur fruit, 12 parts of divaricate saposhnikovia root, 9 parts of perilla leaf, 13 parts of bighead atractylodes rhizome, 8 parts of cassia twig, 6 parts of white paeony root and 8 parts of liquorice, rinsing and airing to obtain a raw material mixture;
(2) decocting the raw material mixture obtained in the step (1) with water for 3 times, adding 10 times of water by mass for the first time, adding 8 times of water by mass for the second time, adding 8 times of water by mass for the third time, decocting for 1.5h each time, combining the decoction, and filtering to obtain a filtrate;
(3) concentrating the filtrate under reduced pressure to obtain thick paste with specific gravity of 1.2, spray drying at inlet temperature of 140 deg.C and outlet temperature of 95 deg.C to obtain extract,
(4) adding 32 parts of lactose, 16 parts of soluble starch and 48 parts of dextrin into the extract, and uniformly mixing; adding 2 parts of lauryl magnesium sulfate for lubrication, and then granulating by using a swinging granulator to obtain the ephedra antiallergic granule.
Example 5
An ephedra antiallergic granule comprises the following raw material components in parts by weight: 30 parts of ephedra, 15 parts of cocklebur fruit, 15 parts of divaricate saposhnikovia root, 12 parts of perilla leaf, 12 parts of largehead atractylodes rhizome, 6 parts of cassia twig, 5 parts of white paeony root and 6 parts of liquorice.
The preparation method of the ephedra antiallergic granule comprises the following steps:
(1) according to the weight, the composition of 30 parts of ephedra, 15 parts of cocklebur fruit, 15 parts of divaricate saposhnikovia root, 12 parts of perilla leaf, 12 parts of largehead atractylodes rhizome, 6 parts of cassia twig, 5 parts of white paeony root and 6 parts of liquorice is rinsed and dried to obtain a raw material mixture;
(2) decocting the raw material mixture obtained in the step (1) with water for 3 times, adding 10 times of water by mass for the first time, adding 8 times of water by mass for the second time, adding 8 times of water by mass for the third time, decocting for 1.5h each time, combining the decoction, and filtering to obtain a filtrate;
(3) concentrating the filtrate under reduced pressure to obtain soft extract with an inlet temperature of 150 deg.C and an outlet temperature of 95 deg.C, and spray drying to obtain extract;
(4) adding 40 parts of lactose, 20 parts of soluble starch and 60 parts of dextrin into the extract, uniformly mixing, adding 2 parts of lauryl magnesium sulfate for lubrication, and granulating by using a swing granulator to obtain the ephedra antiallergic granule.
Example 6
An ephedra antiallergic granule comprises the following raw material components in parts by weight: 30 parts of ephedra, 15 parts of cocklebur fruit, 15 parts of divaricate saposhnikovia root, 12 parts of perilla leaf, 12 parts of largehead atractylodes rhizome, 8 parts of cassia twig, 6 parts of white paeony root and 8 parts of liquorice.
The preparation method of the ephedra antiallergic granule comprises the following steps:
(1) according to the weight, the composition of 30 parts of ephedra, 15 parts of cocklebur fruit, 15 parts of divaricate saposhnikovia root, 12 parts of perilla leaf, 12 parts of bighead atractylodes rhizome, 8 parts of cassia twig, 6 parts of white paeony root and 8 parts of liquorice is rinsed and dried to obtain a raw material mixture;
(2) decocting the raw material mixture obtained in the step (1) with water for 3 times, adding 10 times of water by mass for the first time, adding 8 times of water by mass for the second time, adding 8 times of water by mass for the third time, decocting for 1.5h each time, combining the decoction, and filtering to obtain a filtrate;
(3) concentrating the filtrate under reduced pressure to obtain a thick paste with a concentration of 30% of the total mass of the filtrate, and spray drying at an inlet temperature of 170 ℃ and an outlet temperature of 100 ℃ to obtain an extract;
(4) adding 46 parts of lactose, 23 parts of soluble starch and 69 parts of dextrin into the extract, and uniformly mixing; adding 2 parts of lauryl magnesium sulfate for lubrication, and then granulating by using a swinging granulator to obtain the ephedra antiallergic granule.
Animal toxicity test:
1. taking 90 experimental mice with half male and female parts and weight of 150-190 g, dividing the experimental mice into six groups of 1-6 respectively, 15 mice in each group, ensuring that the physical signs of the mice in each group are good, and the physiological manifestations such as weight and the like are not abnormal and have comparability.
2. Four groups of mice are respectively administered by gastric gavage after being dissolved by the ephedra antiallergic granules prepared in the embodiments 1-6 of the invention, three times a day and continuously taken for one month, and the physical sign conditions of all the mice are observed and recorded during the experiment.
3. The physical signs of all mice in the experimental process are not abnormal, the death condition of the mice does not appear after the experiment is finished, 5 mice in each group are randomly extracted for anatomical examination, no abnormality is found in main organs, and the experimental result shows that the ephedra antiallergic granule has no obvious toxicity and can be safely taken.
The following is the statistical data of the conditioning improvement clinical observation of the medicine of the invention for allergic rhinitis:
1. case selection: 90 clinically diagnosed allergic rhinitis patients, 20-65 years old, 40 men and 20 women are selected and divided into four experimental groups of 1-6, and 15 patients are selected.
2. The experimental method comprises the following steps: the granules prepared in examples 1 to 6 of the present invention were administered to experimental groups 1 to 6 three times a day, 10g each time, continuously for one month, and the recovery of the patients was observed and recorded.
3. The therapeutic effect judgment standard is as follows:
the effect is shown: allergic rhinitis symptoms disappear, all physical signs return to normal, and relapse does not occur within half a year;
the method has the following advantages: the clinical symptoms of allergic rhinitis are improved, and the physical signs of patients are obviously improved compared with those before administration;
and (4) invalidation: the disease condition is not improved or worsened.
4. And (3) experimental data statistics:
5. the experimental results are as follows: the experimental data show that the total effective rate of the ephedra antiallergic granule prepared by the invention for treating allergic rhinitis is 91.1%, and 90 patients do not have any adverse reaction, so that the ephedra antiallergic granule is a safe and effective medicine for treating allergic rhinitis and has good clinical popularization significance.
Claims (9)
1. The Chinese ephedra anti-allergic traditional Chinese medicine composition is characterized by comprising the following raw material medicines in parts by weight: 20-30 parts of ephedra, 10-15 parts of cocklebur fruit, 10-15 parts of divaricate saposhnikovia root, 8-15 parts of perilla leaf, 10-15 parts of bighead atractylodes rhizome, 5-15 parts of cassia twig, 5-15 parts of white paeony root and 5-10 parts of liquorice.
2. The ephedra antiallergic traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 26 parts of ephedra, 12 parts of cocklebur fruit, 12 parts of divaricate saposhnikovia root, 9 parts of perilla leaf, 12 parts of largehead atractylodes rhizome, 6 parts of cassia twig, 5 parts of white paeony root and 6 parts of liquorice.
3. The preparation method of the ephedra antiallergic traditional Chinese medicine composition as claimed in claim 1 or 2, which comprises the following steps:
(1) rinsing and airing ephedra, cocklebur fruit, divaricate saposhnikovia root, perilla leaf, bighead atractylodes rhizome, cassia twig, white paeony root and liquorice according to the proportion to obtain a raw material mixture;
(2) decocting the raw material mixture in water for 3 times, each time for 1.5 hr, mixing decoctions, and filtering to obtain filtrate;
(3) concentrating the filtrate under reduced pressure to obtain soft extract, and drying to obtain extract;
(4) adding adjuvants into the extract, mixing, and granulating with a swing type granulator to obtain herba Ephedrae antiallergic granule.
4. The method of claim 3, wherein the decocting in step (2) comprises adding 10 times of water by mass of the raw material mixture for the first time, 8 times of water by mass of the raw material mixture for the second time, and 8 times of water by mass of the raw material mixture for the third time.
5. The method of claim 3, wherein the filtrate is concentrated to a specific gravity of 1.0-1.2 or to a concentration of 25-30% of the total mass of the filtrate.
6. The method for preparing the ephedra antiallergic traditional Chinese medicine composition according to claim 3, wherein the drying is spray drying, the inlet temperature of the spray drying is 130-180 ℃, and the outlet temperature is 85-105 ℃.
7. The method for preparing the ephedra antiallergic traditional Chinese medicine composition according to claim 3, wherein the amount of the added auxiliary materials is 1-2 times of the amount of the extract; the added auxiliary materials are a mixture of lactose, soluble starch and dextrin according to the mass ratio of 2:1: 3.
8. The method for preparing the ephedra anti-allergic traditional Chinese medicine composition according to claim 3, wherein the lubricant magnesium lauryl sulfate is added when the granulation is carried out by using the swing granulator, and the amount of the added lubricant is 1-2% of the total mass of the extract and the auxiliary materials.
9. The use of the ephedra anti-allergic traditional Chinese medicine composition of claim 2 in the preparation of a medicament for treating allergic rhinitis.
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| 葛根汤的临床新用;阎炯岚;《陕西中医》;19971231;第18卷(第04期);第180-181页 * |
| 赵翠英等.过敏性鼻炎辨证施治的探讨.《中国中西医结合耳鼻咽喉科杂志》.2001,第9卷(第01期), * |
| 过敏性鼻炎辨证施治的探讨;赵翠英等;《中国中西医结合耳鼻咽喉科杂志》;20011231;第9卷(第01期);第17页 * |
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