CN107753584A - A kind of Chinese ephedra antiallergic traditional Chinese medicine composition and preparation method thereof - Google Patents
A kind of Chinese ephedra antiallergic traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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- 241001465251 Ephedra sinica Species 0.000 title claims abstract description 81
- 239000000203 mixture Substances 0.000 title claims abstract description 60
- 230000003266 anti-allergic effect Effects 0.000 title claims abstract description 51
- 239000003814 drug Substances 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 239000008187 granular material Substances 0.000 claims abstract description 29
- 241000132012 Atractylodes Species 0.000 claims abstract description 21
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 21
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 21
- 235000006484 Paeonia officinalis Nutrition 0.000 claims abstract description 21
- 235000004347 Perilla Nutrition 0.000 claims abstract description 21
- 241001251949 Xanthium sibiricum Species 0.000 claims abstract description 21
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 206010039085 Rhinitis allergic Diseases 0.000 claims abstract description 10
- 201000010105 allergic rhinitis Diseases 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 32
- 239000000706 filtrate Substances 0.000 claims description 22
- 241000736199 Paeonia Species 0.000 claims description 20
- 241000229722 Perilla <angiosperm> Species 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 10
- 238000001694 spray drying Methods 0.000 claims description 9
- 229920001353 Dextrin Polymers 0.000 claims description 8
- 239000004375 Dextrin Substances 0.000 claims description 8
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 8
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- 208000006673 asthma Diseases 0.000 description 6
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- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 229930013930 alkaloid Natural products 0.000 description 3
- 150000003797 alkaloid derivatives Chemical class 0.000 description 3
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- 229910052749 magnesium Inorganic materials 0.000 description 3
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- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
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- HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 description 2
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- 206010063659 Aversion Diseases 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012434 Dermatitis allergic Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 241000723281 Ephedra equisetina Species 0.000 description 1
- 241000723237 Ephedra intermedia Species 0.000 description 1
- 241000218670 Ephedraceae Species 0.000 description 1
- 102100030279 G-protein coupled receptor 35 Human genes 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
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- 238000005516 engineering process Methods 0.000 description 1
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- 231100000252 nontoxic Toxicity 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The present invention relates to tcm field, specifically a kind of Chinese ephedra antiallergic traditional Chinese medicine composition and preparation method thereof.The Chinese medicine composition is made up of the raw material of following parts by weight：20 ~ 30 parts of Chinese ephedra, 10 ~ 15 parts of the achene of Siberian cocklebur, windproof 10 ~ 15 parts, perilla leaf 8 ~ 15,10 ~ 15 parts of the bighead atractylodes rhizome, 5 ~ 15 parts of cassia twig, 5 ~ 15 parts of the root of herbaceous peony, 5 ~ 10 parts of radix glycyrrhizae.The present invention has effectively been played the medicinal effects of Chinese ephedra etc., Chinese ephedra antiallergy granule is made, effectively treats allergic rhinitis, technique is simple, applied widely, has no toxic side effect by the reasonable compatibility of plurality of Chinese.
Description
Technical field
The present invention relates to tcm field, specifically a kind of Chinese ephedra antiallergic traditional Chinese medicine composition and preparation method thereof.
Background technology
Anaphylactia mainly includes：Eczema, allergic dermatitis, allergic conjunctivitis, enteritis anaphylactica, allergia nose
Inflammation, allergic asthma (abbreviation asthma) etc..These anaphylactias can individualism, also mutually and can deposit and cause multisystem mistake
It is quick.Many epidemiological investigations confirm that in recent years, the incidence of disease of anaphylactia is constantly soaring in the world,
As very noticeable social concern, wherein climbing highest is allergic asthma and allergic rhinitis.Not only give day
Often life brings inconvenience, causes mental suffering, reduces quality of life, and the duration is grown, and some turns into obstinate disease,
Also having causes died.
Chinese ephedra is Ephedraceae plant ephedra sinica（Ephedra sinicaStapf）, epheday intermedia（Ephedra intermedia
SchrenketC.A.Mey.）Or the drying herbaceous stem stem of ephedra equisetina (Ephedra equisetinaBge.).Chinese ephedra has in China
Long medicinal history, ancient Chinese medicine doctor are used as inducing sweat and dispelling exogenous evils, freeinged lung and relieving asthma, and the medicine of inducing diuresis for removing edema uses.Wherein alkaloid
Constituents are considered as the active ingredient that Chinese ephedra is relievingd asthma, and there is the constituents similar adrenergic sympathetic activation to act on.
In recent years, as the research to Chinese ephedra deepens continuously, the pharmacological action report about Chinese ephedra non-alkaloid constituents also constantly increases
It is more.There are the non-alkaloid constituents in studies have shown that Chinese ephedra that there is hypotensive, hypoglycemic, anti-oxidant, anticoagulation and suppress to exempt from
The pharmacological actions such as epidemic disease.Non-alkaloid constituents herbaceous stem element in ephedra sinica has the activity of stronger exciting GPR35 acceptors, and this is
Further develop, new thinking is provided using Ephedra resources.
The content of the invention
It is an object of the invention to provide a kind of Chinese ephedra antiallergic traditional Chinese medicine composition and preparation method thereof.
The purpose of the present invention is achieved through the following technical solutions：
A kind of Chinese ephedra antiallergic traditional Chinese medicine composition, is made up of the raw material of following parts by weight：20 ~ 30 parts of Chinese ephedra, the achene of Siberian cocklebur 10 ~ 15
Part, windproof 10 ~ 15 parts, perilla leaf 8 ~ 15,10 ~ 15 parts of the bighead atractylodes rhizome, 5 ~ 15 parts of cassia twig, 5 ~ 15 parts of the root of herbaceous peony, 5 ~ 10 parts of radix glycyrrhizae.
Further, above-mentioned a kind of Chinese ephedra antiallergic traditional Chinese medicine composition, is made up of the raw material of following parts by weight：Chinese ephedra 26
Part, 12 parts of the achene of Siberian cocklebur, windproof 12 parts, 9 parts of perilla leaf, 12 parts of the bighead atractylodes rhizome, 6 parts of cassia twig, 5 parts of the root of herbaceous peony, 6 parts of radix glycyrrhizae.
A kind of above-mentioned Chinese ephedra antiallergic traditional Chinese medicine composition, the formulation of the Chinese medicine composition is granule.
The preparation method of above-mentioned Chinese ephedra antiallergic traditional Chinese medicine composition, comprises the following steps：
（1）It will be dried by proportioning after Chinese ephedra, the achene of Siberian cocklebur, windproof, perilla leaf, the bighead atractylodes rhizome, cassia twig, the root of herbaceous peony, radix glycyrrhizae rinsing, obtain raw material
Mixture；
（2）Raw mixture is added water to cook 3 times, decocts 1.5h every time, merges decoction liquor, filtering, obtains filtrate；
（3）Filtrate decompression is dried after being concentrated into paste, obtains extract；
（4）Auxiliary material is added in extract to be well mixed, and is pelletized with oscillating granulator, is produced Chinese ephedra antiallergy granule.
Further, the preparation method of above-mentioned Chinese ephedra antiallergic traditional Chinese medicine composition, step（2）Added for the first time during middle decoction
The water of 10 times of quality of raw mixture, second of the water for adding 8 times of quality of raw mixture, third time add raw mixture 8
The water of times quality.
Further, the preparation method of above-mentioned Chinese ephedra antiallergic traditional Chinese medicine composition, filtrate are concentrated into proportion as 1.0 when concentrating
~ 1.2 or it is concentrated to the 25 ~ 30% of filtrate gross mass.
Further, the preparation method of above-mentioned Chinese ephedra antiallergic traditional Chinese medicine composition, the drying are spray drying, and spraying is dry
Dry inlet temperature is 130 ~ 180 DEG C, and outlet temperature is 85 ~ 105 DEG C.
Further, the preparation method of above-mentioned Chinese ephedra antiallergic traditional Chinese medicine composition, the amount of added auxiliary material is extract quality
1 ~ 2 times amount；Added auxiliary material is lactose, soluble starch and dextrin according to mass ratio 2:1:3 mixture.
Further, the preparation method of above-mentioned Chinese ephedra antiallergic traditional Chinese medicine composition, needed when being pelletized using oscillating granulator
Lubricant Stepanol MG is added, the amount for adding lubricant is the 1% ~ 2% of extract and auxiliary material gross mass.
Above-mentioned Chinese ephedra antiallergic traditional Chinese medicine composition is applied in allergic rhinitis medicine is treated.
It is as follows the effect of each Chinese medicine material medicinal material in the present invention：
The achene of Siberian cocklebur：With expelling cold, eliminating, clearing the nasal passage, wind-damp dispelling, the effect of analgesic, for anemofrigid cold, nasosinusitis, arthralgia pain due to rheumatism,
Rubella convulsion is itched.
It is windproof：Alias copper rue, Hui Yun, return grass, hundred, hundred kinds.Acrid flavour, sweet, slightly warm in nature.Expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion,
Only the effect of convulsion.
Perilla leaf：Pungent, tepor, it is nontoxic.Deliver, cold dispelling, qi-regulating, and battalion.Cure cold chill, fever with aversion to cold, coughs, headache
It is lossless, asthma, fullness and oppression of chest and abdomen, evil of vomitting diarrhoea, block in pharynx, pernicious vomiting, fetal irritability.
The bighead atractylodes rhizome, property is bitter, sweet, temperature.Returns spleen, stomach.It is major function strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, antiabortive.For spleen
Empty deficiency of food, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability.
Cassia twig, property acrid, sweet, warm.The thoughts of returning home, lung, bladder warp.There are sweating expelling pathogenic factors from muscles and skin, warming meridians and promoting circulation of qi, helps yang transforming qi, eliminating cold to stop pain
The effect of.
The root of herbaceous peony, it is cool in nature, bitter acid, it is slightly cold, there is enrich blood soft liver, smooth liver and relieve pain, hold back cloudy receipts sweat and other effects.
Radix glycyrrhizae, gas is micro-, sweet and special.Major function is clearing heat and detoxicating, expelling phlegm and arresting coughing, gastral cavity abdomen etc..
Compared with prior art, the method have the advantages that：
Be the hedge of the person 1. lung governing skin and hair, exterior deficiency then susceptible exopathogen and fall ill.Chinese ephedra relieving the exterior syndrome with drugs pungent in flavor and warm in property facilitaing lung of the present invention, purple perilla
Leaf inducing sweat and dispelling exogenous evils, the spleen and lung stagnation of the circulation of vital energy is dredged in outer dispersing wind and cold, and achene of Siberian cocklebur expelling cold, eliminating is apt to clearing the nasal passage, windproof expelling wind and eliminating dampness, cassia twig expelling pathogenic factors from muscles and skin
Deliver, helps yang transforming qi, four medicines share expelling cold and relieving exterior syndrome, declare logical lung to defend.The moon, two medicines mediation gas are held back in bighead atractylodes rhizome strengthening the spleen and replenishing qi, root of herbaceous peony blood-nourishing
Blood, makes qi and blood prosperous and disease is gone.Radix glycyrrhizae coordinating the drug actions of a prescription makes fever and chills reconcile, and lifting is orderly.The present invention passes through the reasonable of plurality of Chinese
Compatibility, the medicinal effects of Chinese ephedra etc. are effectively played, Chinese ephedra antiallergy granule is made, effectively treats allergic rhinitis, work
Skill is simple, applied widely, has no toxic side effect.
2. granular form is made in the present invention, Chinese medicine, which is decocted, to be carried fully, is carried easy to use.
Embodiment
Below in conjunction with specific embodiment, the present invention will be further described.
Embodiment 1
A kind of Chinese ephedra antiallergy granule, include the raw material components of following parts by weight：20 parts of Chinese ephedra, 10 parts of the achene of Siberian cocklebur, windproof 11
Part, 8 parts of perilla leaf, 13 parts of the bighead atractylodes rhizome, 5 parts of cassia twig, 9 parts of the root of herbaceous peony, 7 parts of radix glycyrrhizae.
A kind of preparation method of above-mentioned Chinese ephedra antiallergy granule, comprises the following steps：
（1）By weight, 20 parts of Chinese ephedra, 10 parts of the achene of Siberian cocklebur, windproof 11 parts, 8 parts of perilla leaf, 13 parts of the bighead atractylodes rhizome, 5 parts of cassia twig, white is taken
Dried after 7 parts of 9 parts of Chinese herbaceous peony, radix glycyrrhizae composition rinsings, obtain raw mixture；
（2）By step（1）In obtained raw mixture add water to cook 3 times, for the first time plus 10 times of quality water, second plus 8
The water of the water of times quality, third time plus 8 times of quality, decocts 1.5h every time, merges decoction liquor, filtering, obtains filtrate；
（3）Filtrate decompression is concentrated into the paste of proportion 1.0, spray drying, and inlet temperature is 130 DEG C, and outlet temperature is 85 DEG C,
Obtain extract,
（4）20 parts of lactose, 10 parts of soluble starch, 30 parts of dextrin are added in extract, is well mixed；Take 1 part of dodecyl
Magnesium sulfate lubricates, and is pelletized afterwards with oscillating granulator, produces Chinese ephedra antiallergy granule.
Embodiment 2
A kind of Chinese ephedra antiallergy granule, include the raw material components of following parts by weight：20 parts of Chinese ephedra, 10 parts of the achene of Siberian cocklebur, windproof 11
Part, 8 parts of perilla leaf, 11 parts of the bighead atractylodes rhizome, 5 parts of cassia twig, 10 parts of the root of herbaceous peony, 5 parts of radix glycyrrhizae.
A kind of preparation method of above-mentioned Chinese ephedra antiallergy granule, comprises the following steps：
（1）By weight, 20 parts of Chinese ephedra, 10 parts of the achene of Siberian cocklebur, windproof 11 parts, 8 parts of perilla leaf, 11 parts of the bighead atractylodes rhizome, 5 parts of cassia twig, white is taken
Dried after 5 parts of 10 parts of Chinese herbaceous peony, radix glycyrrhizae composition rinsings, obtain raw mixture；
（2）By step（1）In obtained raw mixture add water to cook 3 times, for the first time plus 10 times of quality water, second plus 8
The water of the water of times quality, third time plus 8 times of quality, decocts 1.5h every time, merges decoction liquor, filtering, obtains filtrate；
（3）Filtrate decompression is concentrated into the paste of proportion 1.0, spray drying, and inlet temperature is 130 DEG C, and outlet temperature is 85 DEG C,
Obtain extract,
（4）22 parts of lactose, 11 parts of soluble starch, 33 parts of dextrin are added in extract, is well mixed；Take 2 parts of dodecyls
Magnesium sulfate lubricates, and is pelletized afterwards with oscillating granulator, produces Chinese ephedra antiallergy granule.
Embodiment 3
A kind of Chinese ephedra antiallergy granule, include the raw material components of following parts by weight：26 parts of Chinese ephedra, 12 parts of the achene of Siberian cocklebur, windproof 12
Part, 9 parts of perilla leaf, 12 parts of the bighead atractylodes rhizome, 6 parts of cassia twig, 5 parts of the root of herbaceous peony, 6 parts of radix glycyrrhizae.
A kind of preparation method of above-mentioned Chinese ephedra antiallergy granule, comprises the following steps：
（1）By weight, 26 parts of Chinese ephedra, 12 parts of the achene of Siberian cocklebur, windproof 12 parts, 9 parts of perilla leaf, 12 parts of the bighead atractylodes rhizome, 6 parts of cassia twig, white is taken
Dried after 6 parts of 5 parts of Chinese herbaceous peony, radix glycyrrhizae composition rinsings, obtain raw mixture；
（2）By step（1）In obtained raw mixture add water to cook 3 times, for the first time plus 10 times of quality water, second plus 8
The water of the water of times quality, third time plus 8 times of quality, decocts 1.5h every time, merges decoction liquor, filtering, obtains filtrate；
（3）Filtrate decompression is concentrated into the paste of proportion 1.0, spray drying, and inlet temperature is 130 DEG C, and outlet temperature is 85 DEG C,
Obtain extract,
（4）24 parts of lactose, 12 parts of soluble starch, 36 parts of dextrin are added in extract, is well mixed；Take 1 part of dodecyl
Magnesium sulfate lubricates, and is pelletized afterwards with oscillating granulator, produces Chinese ephedra antiallergy granule.
Embodiment 4
A kind of Chinese ephedra antiallergy granule, include the raw material components of following parts by weight：26 parts of Chinese ephedra, 12 parts of the achene of Siberian cocklebur, windproof 12
Part, 9 parts of perilla leaf, 13 parts of the bighead atractylodes rhizome, 8 parts of cassia twig, 6 parts of the root of herbaceous peony, 8 parts of radix glycyrrhizae.
A kind of preparation method of above-mentioned Chinese ephedra antiallergy granule, comprises the following steps：
（1）By weight, 26 parts of Chinese ephedra, 12 parts of the achene of Siberian cocklebur, windproof 12 parts, 9 parts of perilla leaf, 13 parts of the bighead atractylodes rhizome, 8 parts of cassia twig, white is taken
Dried after 8 parts of 6 parts of Chinese herbaceous peony, radix glycyrrhizae composition rinsings, obtain raw mixture；
（2）By step（1）In obtained raw mixture add water to cook 3 times, for the first time plus 10 times of quality water, second plus 8
The water of the water of times quality, third time plus 8 times of quality, decocts 1.5h every time, merges decoction liquor, filtering, obtains filtrate；
（3）Filtrate decompression is concentrated into the paste that proportion is 1.2, spray drying, and inlet temperature is 140 DEG C, outlet temperature
Spend for 95 DEG C, obtain extract,
（4）32 parts of lactose, 16 parts of soluble starch, 48 parts of dextrin are added in extract, is well mixed；Add the 12 of 2 parts
Alkylsurfuric acid magnesium lubricates, and is pelletized afterwards with oscillating granulator, produces Chinese ephedra antiallergy granule.
Embodiment 5
A kind of Chinese ephedra antiallergy granule, include the raw material components of following parts by weight：30 parts of Chinese ephedra, 15 parts of the achene of Siberian cocklebur, windproof 15
Part, 12 parts of perilla leaf, 12 parts of the bighead atractylodes rhizome, 6 parts of cassia twig, 5 parts of the root of herbaceous peony, 6 parts of radix glycyrrhizae.
A kind of preparation method of above-mentioned Chinese ephedra antiallergy granule, comprises the following steps：
（1）By weight, 30 parts of Chinese ephedra, 15 parts of the achene of Siberian cocklebur, windproof 15 parts, 12 parts of perilla leaf, 12 parts of the bighead atractylodes rhizome, 6 parts of cassia twig, white is taken
Dried after 6 parts of 5 parts of Chinese herbaceous peony, radix glycyrrhizae composition rinsings, obtain raw mixture；
（2）By step（1）In obtained raw mixture add water to cook 3 times, for the first time plus 10 times of quality water, second plus 8
The water of the water of times quality, third time plus 8 times of quality, decocts 1.5h every time, merges decoction liquor, filtering, obtains filtrate；
（3）Filtrate decompression is concentrated into 25% paste of filtrate gross mass, spray drying, and inlet temperature is 150 DEG C, outlet temperature
Spend for 95 DEG C, obtain extract；
（4）40 parts of lactose, 20 parts of soluble starch, 60 parts of dextrin are added in extract, is well mixed, the 12 of 2 parts of addition
Alkylsurfuric acid magnesium lubricates, and is pelletized afterwards with oscillating granulator, produces Chinese ephedra antiallergy granule.
Embodiment 6
A kind of Chinese ephedra antiallergy granule, include the raw material components of following parts by weight：30 parts of Chinese ephedra, 15 parts of the achene of Siberian cocklebur, windproof 15
Part, 12 parts of perilla leaf, 12 parts of the bighead atractylodes rhizome, 8 parts of cassia twig, 6 parts of the root of herbaceous peony, 8 parts of radix glycyrrhizae.
A kind of preparation method of above-mentioned Chinese ephedra antiallergy granule, comprises the following steps：
（1）By weight, 30 parts of Chinese ephedra, 15 parts of the achene of Siberian cocklebur, windproof 15 parts, 12 parts of perilla leaf, 12 parts of the bighead atractylodes rhizome, 8 parts of cassia twig, white is taken
Dried after 8 parts of 6 parts of Chinese herbaceous peony, radix glycyrrhizae composition rinsings, obtain raw mixture；
（2）By step（1）In obtained raw mixture add water to cook 3 times, for the first time plus 10 times of quality water, second plus 8
The water of the water of times quality, third time plus 8 times of quality, decocts 1.5h every time, merges decoction liquor, filtering, obtains filtrate；
（3）Filtrate decompression is concentrated into 30% paste of filtrate gross mass, spray drying, and inlet temperature is 170 DEG C, outlet temperature
Spend for 100 DEG C, obtain extract；
（4）46 parts of lactose, 23 parts of soluble starch, 69 parts of dextrin are added in extract, is well mixed；Add the 12 of 2 parts
Alkylsurfuric acid magnesium lubricates, and is pelletized afterwards with oscillating granulator, produces Chinese ephedra antiallergy granule.
Animal toxicity test：
1. take experiment mice 90, male and female half and half, 150 ~ 190g of body weight is respectively divided into six group 1 ~ 6, every group each 15, every group small
Mouse sign is good, and the physiological performance such as body weight is without exception, has comparativity.
2. gavage is given after the Chinese ephedra antiallergy granule dissolving prepared respectively using the embodiment of the present invention 1 ~ 6 to four groups of mouse
Medicine, three times a day, continuously takes one month, is observed during experiment and records the sign situation of all mouse.
3. the sign performance of all mouse is without exception in experimentation, experiment does not occur dead mouse situation after terminating, right
5 are randomly selected in every group of mouse and carries out dissection inspection, and major organs are no abnormal, from experimental result, the present invention
Chinese ephedra antiallergy granule without overt toxicity, can safety clothes use.
Here is that conditioning of the medicine of the present invention for allergic rhinitis improves clinical observation statistics：
1. case is chosen：The Allergic Rhinitis 90 made a definite diagnosis clinically is chosen, at 20 ~ 65 years old age, male 40, women 20
Example, is divided into four groups of experimental groups 1 ~ 6, every group 15.
2. experimental method：The granule prepared respectively using the embodiment of the present invention 1 ~ 6 to experimental group 1 ~ 6, three times a day, often
Secondary 10g, continuous medication one month, observes and records the recovery situation of patient.
3. curative effect determinate standard：
It is effective：Allergic rhinitis symptoms disappear, and every sign recovers normal, no relapse in half a year；
Effectively：Allergic rhinitis clinical symptoms improve, before patient compares medication the performance of each sign be clearly better；
It is invalid：The state of an illness is without any improvement or aggravates.
4. experimental data counts：
5. experimental result：As can be seen from the above experimental data, the Chinese ephedra antiallergy granule that prepared by the present invention is for anaphylaxis
The total effective rate of the treatment of rhinitis is 91.1%, and 90 patients have no any adverse reaction, therefore is illustrated, Chinese ephedra of the invention
Antiallergy granule is the safe and effective medicine for treating allergic rhinitis, has good clinical expansion meaning.
Claims (10)
1. a kind of Chinese ephedra antiallergic traditional Chinese medicine composition, it is characterised in that be made up of the raw material of following parts by weight：20 ~ 30 parts of Chinese ephedra,
10 ~ 15 parts of the achene of Siberian cocklebur, windproof 10 ~ 15 parts, perilla leaf 8 ~ 15,10 ~ 15 parts of the bighead atractylodes rhizome, 5 ~ 15 parts of cassia twig, 5 ~ 15 parts of the root of herbaceous peony, radix glycyrrhizae 5 ~
10 parts.
2. a kind of Chinese ephedra antiallergic traditional Chinese medicine composition as claimed in claim 1, it is characterised in that by the raw material of following parts by weight
Composition：26 parts of Chinese ephedra, 12 parts of the achene of Siberian cocklebur, windproof 12 parts, 9 parts of perilla leaf, 12 parts of the bighead atractylodes rhizome, 6 parts of cassia twig, 5 parts of the root of herbaceous peony, 6 parts of radix glycyrrhizae.
A kind of 3. Chinese ephedra antiallergic traditional Chinese medicine composition as claimed in claim 1 or 2, it is characterised in that the Chinese medicine composition
Formulation be granule.
4. a kind of preparation method of Chinese ephedra antiallergic traditional Chinese medicine composition as claimed in claim 3, it is characterised in that including following
Step：
（1）It will be dried by proportioning after Chinese ephedra, the achene of Siberian cocklebur, windproof, perilla leaf, the bighead atractylodes rhizome, cassia twig, the root of herbaceous peony, radix glycyrrhizae rinsing, obtain raw material
Mixture；
（2）Raw mixture is added water to cook 3 times, decocts 1.5h every time, merges decoction liquor, filtering, obtains filtrate；
（3）Filtrate decompression is dried after being concentrated into paste, obtains extract；
（4）Auxiliary material is added in extract to be well mixed, and is pelletized with oscillating granulator, is produced Chinese ephedra antiallergy granule.
A kind of 5. preparation method of Chinese ephedra antiallergic traditional Chinese medicine composition as claimed in claim 4, it is characterised in that step（2）
The water of 10 times of quality of raw mixture is added during middle decoction for the first time, for the second time the water of addition 8 times of quality of raw mixture, the 3rd
The secondary water for adding 8 times of quality of raw mixture.
6. a kind of preparation method of Chinese ephedra antiallergic traditional Chinese medicine composition as claimed in claim 4, it is characterised in that filtrate concentrates
When be concentrated into proportion 1.0 ~ 1.2 or to be concentrated to the 25 ~ 30% of filtrate gross mass.
A kind of 7. preparation method of Chinese ephedra antiallergic traditional Chinese medicine composition as claimed in claim 4, it is characterised in that the drying
It is spray drying, the inlet temperature of spray drying is 130 ~ 180 DEG C, and outlet temperature is 85 ~ 105 DEG C.
A kind of 8. preparation method of Chinese ephedra antiallergic traditional Chinese medicine composition as claimed in claim 4, it is characterised in that added auxiliary material
Amount be 1 ~ 2 times of extract quality amount；Added auxiliary material is lactose, soluble starch and dextrin according to mass ratio 2:1:3 it is mixed
Compound.
9. a kind of preparation method of Chinese ephedra antiallergic traditional Chinese medicine composition as claimed in claim 4, it is characterised in that using waving
Formula granulator need to add lubricant Stepanol MG when pelletizing, and the amount for adding lubricant is extract and auxiliary material gross mass
1% ~ 2%.
10. application of the Chinese ephedra antiallergic traditional Chinese medicine composition as claimed in claim 1 or 2 in allergic rhinitis medicine is treated.
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| 阎炯岚: "葛根汤的临床新用", 《陕西中医》 * |
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