CN103585276A - Drug recipe for treating various allergic diseases - Google Patents

Abstract

The invention relates to a drug recipe for treating various allergic diseases. The drug recipe is characterized by comprising drugs such as violet magnolia, radices sileris, ephedra, cocklebur fruit, liquorice, western medicine oxytetracycline, vitamin B1, chlortrimeton and virustat. The drug recipe has a better treatment effect on the various allergic diseases such as allergic rhinitis, urticaria perstans and allergic asthma.

Description

A kind of medicament composing prescription for the treatment of multiple anaphylactic disease

Technical field

The invention belongs to tcm field, relate to a kind of medicament composing prescription for the treatment of various anaphylactic diseases.

Background technology

Allergy is the phenomenon that organism increases abnormally to the susceptibility of some drugs or environmental stimuli, is exactly briefly irritated to certain material.Allergy is a kind of allergy of body, a kind of abnormal reaction of people to koinomatter (anaphylactogen), just can there is allergy in the crowd who touches allergic constitution when anaphylactogen, the hundreds of kinds such as irritated original pollen, dust, foreign protein, chemical substance, ultraviolet.

In whole world medical institutions, suppress inflammation, anaphylactoid medicine and be maximum a kind of of quantity in prescription drugs; Far and away, there are more and more people to be exposed in the increasing pressure environment, this is enough to cause the generation of disease, factor on health, other similarly is wound, sunlight etc., our food, empty G&W are also all exposed in many different chemical mixtures, and wherein some is unfavorable for our health, for example: pollen.Clearly, our identity is sunk in all-environment pressure, according to the difference of our indivedual body make-ups, for the reaction of these ambient pressures, be to produce various diseases, conventionally all can be accompanied by the red, swollen, bitterly or tear, the secretion of nasal mucus and other following symptom of skin:

Allergic rhinitis be a kind of suck extraneous anaphylaxis antigen and cause take rhinocnesmus, beat sneeze, disease that snivel etc. is cardinal symptom.Symptom mainly contains three: the one, and the successional sneeze of paroxysmal, each outbreak is generally no less than 5, when many, even reach tens, tens, the time of sneeze often, to fall asleep at getting up early, night or to increase the weight of with conversion in season, has and can show effect several times serious almost every day; The 2nd, the nasal mucus of a large amount of clear water samples after sneeze process; The 3rd, the obstruction of nasal cavity, or not sustainable tens minutes or dozens of minutes are not etc. for the light and heavy degree of each outbreak.Allergic dermatitis main manifestations is red swelling of the skin, scratch where it itches, pain, urticaria, eczema, macule, pimple, welt erythra, purpura etc.Allergic asthma is apt to occur in that spring, the flowers are in blossom season, and cold season autumn and winter, sensitization medium acts in bronchus, makes bronchial muscular spasm, causes extensive small airway narrow, causes and breathes heavily, suppresses, coughs, and severe patient suffocates even dead.

Most of doctors can control irritated inflammation disease with medicine, comprise and give antihistamine drug, and current clinical pure Western medicine preparation is often followed many side effect, as drowsiness, Liver and kidney injury, immunity injury, hormone knock-ons etc., if women takes antihistaminic for continuous 5 years, the physiology phase can stop.Therefore should not long-term, large dose oral administration.Some antiallergic agent can stimulate the nerve of being satiated with food of body, produces obesity action.

Chinese medicine is drawn materials natural, and human body is had to good adaptability, and assistant, with the Western medicine of suiting the medicine to the illness, is used in conjunction with, and can effectively treat various allergic symptoms.

Technology contents

The object of this invention is to provide a kind of medicament composing prescription for the treatment of multiple anaphylactic disease, this prescription has good therapeutical effect for various anaphylactic diseases such as allergic rhinitis, urticaria perstans, allergic asthmas.

The present invention treats the medicament composing prescription of multiple anaphylactic disease, following active component, consists of:

Flos Magnoliae, Radix Saposhnikoviae, Herba Ephedrae, Fructus Xanthii, Radix Glycyrrhizae, Western medicine oxytetracycline, vitamin B1, chlorphenamine, moroxydine.

The present invention treats the medicament composing prescription of multiple anaphylactic disease, and its active component weight proportion of selecting is:

2 parts of Flos Magnoliaes, 2 parts of Radix Saposhnikoviaes, 1 part, Herba Ephedrae, 2 parts of Fructus Xanthii, 1 part, Radix Glycyrrhizae, 1 part of (0.25g of Western medicine oxytetracycline, specification tablet), vitamin B12 part (10mg specification, tablet), chlorphenamine 1 part of (4mg specification, tablet), 2 parts of moroxydine (0.1g specification, tablet).

The pharmacological basis of the selected medicine of medicament composing prescription of the present invention is:

Flos Magnoliae, acrid in the mouth, micro-hardship, warm in nature.Attach to the lung and stomach meridians.Dispersing wind and cold, clearing the nasal passage.For headche due to wind-cold, nasal obstruction, nasal sinusitis, turbid nasal discharge.< < does not record > >: warming middle-JIAO expelling pathogenic factors from muscles, and sharp nine orifices, stuffy nose relieving plug, tears go out, and control swelling of the face and draw toothache, dizziness.Raw beard and hair, removes tapeworm.< < Japan hanako materia medica > >: the arteries and veins of being open to the custom, improving eyesight.Control headache, the loathing of cold, body are kept silent, pruritus.. < < Compendium of Materia Medica > >: lung opening at nose, and positive bright the stomach pulse ring nose and up, the brain being the house of mentality, the key that nose is the gate of vitality; QI-insufficiency among people, clear YANG failing to ascend, head inclines for it, and nine orifices is unfavorable for it.The pungent temperature of Flos Magnoliae is flat and enter lung, can help in stomach and work in sky on clear sun, so can warming middle-JIAO control the disease of women's head-ornaments order nose.

Experiment shows, Flos Magnoliae has convergence and protective effect to nasal mucosa, and secretions is reduced, local Marjoram Extract, and circulation improves, and can promote secretions to absorb and inflammation disappears.Flos Magnoliae topical application, has antiinflammatory, analgesia, anti-allergic effects.

Radix Saposhnikoviae, acrid in the mouth, sweet, slightly warm in nature.Return urinary bladder channel, lung meridian, spleen channel, Liver Channel.Expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.Cure mainly affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint is ached, stomachache is had loose bowels, discharging fresh blood stool, tetanus, rubella pruritus, skin infection from the beginning of.Experimentation shows that Radix Saposhnikoviae has good antiinflammatory, calmness and anti-allergic effects.

Herba Ephedrae, acrid in the mouth, micro-hardship, warm in nature.Return lung, urinary bladder channel.Diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.For diseases caused by exogenous pathogenic factor wind plug, fever with aversion to cold, head, body pain, nasal obstruction, lossless, the exterior excess syndromes such as floating and tense pulse.This product energy lung qi dispersing gas, loosing the interspaces of skin and muscles, dispersing wind and cold, with relieving the exterior syndrome by diaphoresis.In Ephedra sinica stem, contain alkaloid 1%～2%, in its alkaloid, 40%～90% is ephedrine, is secondly pseudoephedrine.Antisensitizer hundred be fine, hundred for happy, hundred for Sino-Kazakhstan, all contain a certain amount of ephedrine composition.

Fructus Xanthii, bitter in the mouth, sweet, pungent, warm in nature.Mild toxicity.Enter liver, kidney, lung meridian.Dispersing wind and cold; Clearing the nasal passage; Wind-damp dispelling; Antipruritic.Cure mainly nasal sinusitis; Headche due to wind-cold; Rheumatic arthralgia; Rubella; Eczema; Scabies.

Radix Glycyrrhizae, sweet in the mouth, property is flat.Enter spleen, stomach, lung meridian.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.For insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse, and deficiency of spleen-QI and stomach-QI, fatigue and weakness, asthma and cough etc.In addition, be also commonly used to coordinating the actions of various ingredients in a prescription.

Radix Glycyrrhizae has antiinflammatory, and anti-allergic effects can be protected throat and the tunica mucosa tracheae of inflammation.Radix Glycyrrhizae extractum and glycyrrhizic acid have the Detoxication of similar glucuronic acid to some poisonous substance.Radix Glycyrrhizae is in we, to belong to make the medicine guide drugs diseased region that goes directly, and has mediation effect concurrently.In such event, medicine needn't run to other organ, causes other organs to be subject to the unnecessary effect infringement of medicine, reduces side effect.

Oxytetracycline is broad-spectrum antibacterial agent, and many rickettsiaes, Mycoplasma, chlamydiaceae, spirillum, ameba and some plasmodium are also responsive to these product.Enterococcus is to its drug resistance.Other are as responsive to these product in actinomyces, anthrax bacillus, listerisa monocytogenes in mjme, clostridium, slave block Pseudomonas, vibrio, Brucella, Campylobacter, yersinia etc.Also can be used for the patient that infect tetanus, gas gangrene, refined department, syphilis, gonorrhea and leptospirosis to penicillin anaphylaxis and actinomyces, Listerella.

Vitamin B1, raw plain B1 is human energy metabolism, and particularly carbohydrate metabolism is necessary, and old friend's body is conventionally relevant with the heat of picked-up to the requirement of thiamine.When the energy of human body is mainly derived from saccharide, the requirement of vitamin B1 is maximum.Vitamin B1 still maintains heart, and nerve and digestive system normal function are necessary.When Vitamin B1 deficiency, by its degree, can there is following reaction successively: nervous system reaction (dry beriberi), cardiovascular system reaction (beriberi humida) Wernicke (Wei Nikeshi) encephalopathy and Korsakoff syndrome (Korakaff's psychosis).Many neural Signs and symptom are peripheral neuritiss, with acra sensory disturbance, comprise regional area hyperesthesia or stolidity.Dyspnea when cardiovascular symptom comprises work, cardiopalmus, tachycardia and the abnormal situation of other electrocardiograms, and highoutput type heart failure.This exhaustion is called " moist pedopathy ".It is with edema widely.

Chlorphenamine, chlorpheniramine, is one of the strongest antihistaminic, sedation compared with promethazine a little less than, also have certain cholinolytic effect.This medicine reversibility is captured histamine receptor, competitive blocking histamine and receptors bind, thereby performance antihistamine effect.Histamine receptor has two types of H1 and H2, produces different effects when exciting.During H1 receptor agonism, can cause that bronchus and gastrointestinal smooth muscle shrink, to relax the VSM, heart muscle shrinks to be strengthened, and Atrioventricular Conduction slows down etc.During H2 receptor agonism, can cause parietal cell secretion gastric acid increase etc.This two classes effect is respectively by different medicine institute antagonisms.H1 receptor antagonist has replaced the histamine in body, its effect of competitive antagonism, it can not deactivation histamine, do not suppress yet its synthetic with discharge.Therefore be mainly used in alleviating anaphylactoid symptom, as urticaria, vasodilation, rhinitis, conjunctivitis, also can alleviate pruritus due to dermatosis; Some traditional H1 receptor antagonists can antagonism acetylcholine, 5-HT, epinephrine, and has local anesthetic action; H1 receptor is picked up anti-agent and is told effect as diphenhydramine, dimenhydrinate, promethazine Deng Yinju town, can be used for treating the nausea,vomiting,diarrhea symptom of Meniere and relevant disease.

Moroxydine, i.e. moroxydine hydrochloride.This medicine can suppress viral DNA and the activity of RNA polymerase and synthesizing of protein, thereby suppresses virus breeding.In HEKC, 1% concentration has obvious inhibitory action to DNA viruses (adenovirus, herpesvirus) and RNA viruses (echovirus), and all there is to inhibitory action in each stage of viral multiplication cycle.For influenza virus and herpesvirus infection. also can be used for bird flu, viral bronchitis, Marek's disease, treatment pigeon variola etc.

The medicament composing prescription that the present invention treats various anaphylactic diseases is for for oral administration, can decoct according to routine, brewed use, also can according to preparation technique, make according to clinical demand the dosage forms such as corresponding pill, tablet, capsule and powder.

The Chinese prescription of the various anaphylactic diseases for the treatment of of the present invention, through fine setting for several times, has formed comparatively clear and definite treatment curative effect.

Main list of references: [1] Zhou Wenxue. brief talk the anti-allergic effects [J] of Flos Magnoliae. Chinese modern medicine and clinical, 2007, 6 (5): 43.[2] Li Xiaoli, Zhang Yongzhong. the antiallergic experimentation [J] of Flos Magnoliae volatile oil. Journal of Chinese Hospital Pharmacy, 2002, 22 (9): 520.[3] Zhang Chunyan, Li Yaming, Zhang Qiaoyan. Fructus Xanthii, Flos Magnoliae medicine is to chemical composition of volatile oil and to antihistamine, skin allergy due to serotonin [J]. geriatrics and health care, 2008.14 (3): 172.[4] Lee's war, Wu Min. the clinical pharmacology progress [J] of Flos Magnoliae and Fructus Xanthii. Shanghai Second Emdical University's journal, 2004, 24 (5): 393.[5] Gan Xiuhong, Lu Minhui, Deng Chunli. the Chinese traditional treatment of allergic asthma [J]. Chinese medicine, 2008, 5 (2): 152.[6] Fang Xiaoqun, peace is vertical, Liu Zhao. Flos Magnoliae Fructus Xanthii powder associating Seeley is for piperazine treatment clinical observation on allergic rhinitis [J]. Asia-Pacific traditional medicine, 2010, 6 (6): 44.[7] Hua Xiaodong, Yin Chunhui. antiallergic Chinese medicine and study on mechanism progress [J] thereof. Tianjin pharmacy, 2009, 21 (6): 69.[8] old building, Liu Min, Wang Mei, Deng. Herba Ephedrae connects a light horse cart Semen Phaseoli soup side of tearing open antianaphylaxis effect research [J]. Jilin Chinese medicine, 2007, 27 (11): 55.[9] Ou Yangyanhong, Li Baoshan, Yuan Suqin. the preparation of glycyrrhiza compound ointment and at the observation of curative effect [J] for the treatment of allergic dermatitis and skin pruritus. Mountain Western Medicine S University's journal, 2006, 37 (10): 1028.[10] Bai Limei. SNMC in Treatment anaphylactoid purpura clinical observation [J]. medical information, 2011, 24 (12): 155.

Specific embodiment

(1) raw material disposal

Flos Magnoliae: get Flos Magnoliae, choose decontamination and anthocaulus, the spare of winnowing with a dustpan is stand-by.Radix Saposhnikoviae: get crude drug, remove impurity and feeler, clean, run through, cut sheet, dry.Herba Ephedrae: decontamination, with warm water bubble a moment slightly, drag in basket, the upper cover cloth that wet, next day, taking-up, first selected root, after be cut into 3 minutes long transverse sheets, dry.Fructus Xanthii: get crude drug, remove impurity.Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly time to eighty per cant, run through section, dry.

(2) adapted of medicine

Get the 1 gram of pulverizing of 2 grams of 1 gram, 2 grams of 2 grams of Flos Magnoliaes, Radix Saposhnikoviaes, Herba Ephedrae, Fructus Xanthii, Radix Glycyrrhizae cooking, mix homogeneously, add boiled water to soak after 30 minutes and add 1 (0.25g of Western medicine oxytetracycline, specification tablet), vitamin B12 sheet (10mg specification, tablet), 1 (4mg specification of chlorphenamine, tablet), 2 of moroxydines (0.1g specification, tablet).Take after opening until tablet is molten, onset in approximately 30 minutes, can eliminate rhinitis, urticaria perstans, asthma allergic symptom fast.

Claims (2)

1. treat a medicament composing prescription for multiple anaphylactic disease, it is characterized in that being formed by following component:

Flos Magnoliae, Radix Saposhnikoviae, Herba Ephedrae, Fructus Xanthii, Radix Glycyrrhizae, Western medicine oxytetracycline, vitamin B1, chlorphenamine, moroxydine.

2. the medicament composing prescription of the multiple anaphylactic disease for the treatment of as claimed in claim 1, it selects each composition weight proportioning to be:

2 parts of Flos Magnoliaes, 2 parts of Radix Saposhnikoviaes, 1 part, Herba Ephedrae, 2 parts of Fructus Xanthii, 1 part, Radix Glycyrrhizae, 1 part of (0.25g of Western medicine oxytetracycline, specification tablet), vitamin B12 part (10mg specification, tablet), chlorphenamine 1 part of (4mg specification, tablet), 2 parts of moroxydine (0.1g specification, tablet).