CN115779025B - Traditional Chinese medicine preparation for treating female acne and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating female acne and a preparation method thereof, wherein the medicine is prepared from dandelion, fructus forsythiae, bighead atractylodes rhizome, chinese angelica, poria cocos, ligusticum wallichii, white paeony root, rhizoma alismatis, radix angelicae, almond and balloonflower root by adding, subtracting, modifying and cutting: radix Scutellariae for patients with rash and cheek diseases; fructus Gardeniae and cortex Phellodendri can be added for patients with rash and chin and mandible; facial greasiness: adding the three immortals; rhizoma Pinelliae with thick and greasy coating. The invention has the effects of clearing heat and detoxicating, strengthening spleen and resolving fluid retention and harmonizing qi and blood for the female acne with heat toxin accumulated in the upper-jiao head, face, chest and back, and the basis of pathogenesis of phlegm and fluid retention and resolving heat, namely spleen deficiency fluid retention or qi and blood disharmony. All Fang Hanwen are used together to achieve the purpose of eliminating acne.

Description

Traditional Chinese medicine preparation for treating female acne and preparation method thereof

Technical Field

The invention relates to the field of medicines, in particular to a traditional Chinese medicine preparation for treating female acne and a preparation method thereof.

Background

Acne Vulgaris (abbreviated as "Acne", acne Vulgaris, AV) is a chronic inflammatory skin disease affecting the hair follicle-sebaceous glands, one of the common damage-tolerant skin diseases, and many patients, especially women, are saturated and disturbed by it. The pathogenesis of the acne is generally considered to be related to hormone level imbalance, propionibacterium acnes colonization, hair follicle keratinization abnormality, genetic related factors and the like, wherein the hormone level has important influence on the occurrence and development of the disease, the hormone level is mainly used for stimulating the excessive secretion of sebaceous glands by promoting the excessive keratinization of the hair follicle, and the specific mechanism is as follows: 1) Fibroblast production is promoted by affecting fibroblasts, which leads to excessive keratinization of the follicular orifice, sebum accumulation, and inflammatory production. 2) By promoting the occurrence of the mammalian rapamycin target C1 pathway (mORC 1), the sterol regulatory element binding protein-1 (SREBP-1) is activated to promote the synthesis and secretion of lipids.

In clinical practice, the inventor finds that in addition to the heat toxin syndrome, female acne patients commonly have symptoms of deficiency-excess inclusion and cold-heat mix-up, such as: cold limbs, pale complexion or pale complexion, tender flesh, calm and lazy movements, shortness of breath and lazy speaking, tiredness and hypodynamia or dizziness and palpitation, insomnia and dreaminess, pale and fat tongue with white or thick greasy coating, deep and thin and weak pulse and the like, which are often accompanied with thirst and poor appetite, red face, greasy and desquamation, yellow greasy coating and yellow greasy coating, and rash is manifested as red pimple, painful nodule and cyst, and the rash is obviously aggravated after eating and staying up night. However, the existing medicines and treatment methods for treating the diseases are more, but the treatment effect is not ideal, the disease is easy to relapse, and radical cure is difficult to achieve.

Disclosure of Invention

The invention aims at a traditional Chinese medicine compound for treating female acne and a preparation method thereof, and has obvious curative effects on female heat toxin flaming up and skin accumulation (heat toxin upper accumulation or heat toxin skin accumulation) accompanied with spleen deficiency and fluid retention or qi and blood disharmony type acne.

The technical scheme of the invention is as follows:

a traditional Chinese medicine preparation for treating female acne comprises the following medicinal active ingredients in parts by weight: is prepared from dandelion 100-220 parts, weeping forsythia 100-220 parts, bighead atractylodes rhizome 80-200 parts, chinese angelica 40-160 parts, poria cocos 80-200 parts, ligusticum wallichii 40-160 parts, white peony root 100-450 parts, alisma 100-220 parts, dahurian angelica root 50-180 parts, apricot kernel 50-180 parts and balloonflower root 50-180 parts.

The traditional Chinese medicine preparation for treating female acne comprises the following medicinal active ingredients in parts by weight: is prepared from 130-170 parts of dandelion, 130-170 parts of weeping forsythia, 100-140 parts of bighead atractylodes rhizome, 70-110 parts of angelica, 100-140 parts of poria cocos, 70-110 parts of ligusticum wallichii, 200-400 parts of white peony root, 130-170 parts of rhizoma alismatis, 80-120 parts of radix angelicae, 80-120 parts of almond and 80-120 parts of balloonflower root.

Specifically, the traditional Chinese medicine preparation for treating female acne comprises the following medicinal active ingredients in parts by weight: is prepared from 150 parts of dandelion, 150 parts of weeping forsythia, 120 parts of bighead atractylodes rhizome, 90 parts of Chinese angelica, 120 parts of poria cocos, 90 parts of ligusticum wallichii, 300 parts of white peony root, 150 parts of rhizoma alismatis, 100 parts of radix angelicae, 100 parts of almond and 100 parts of platycodon grandiflorum.

More specifically, the traditional Chinese medicine preparation for treating female acne has the defect that acne patients have rash with cheeks, and 100-220 parts of radix scutellariae is added in the formula.

More specifically, the traditional Chinese medicine preparation for treating female acne is mainly prepared from 50-200 parts of cape jasmine and 40-160 parts of salted phellodendron bark in the formula, wherein the acne patient has rash and chin and lower jaw.

More specifically, the traditional Chinese medicine preparation for treating female acne has thick greasy coating on acne patients, and 40-160 parts of rhizoma pinellinae praeparata are added in the formula.

More specifically, the traditional Chinese medicine preparation for treating female acne has oily face for acne patients, and 40-160 parts of malt, 40-160 parts of hawthorn and 40-160 parts of Jianqu are added in the formula.

The preparation method of the traditional Chinese medicine preparation for treating female acne comprises the steps of weighing all the medicinal materials according to a proportion, processing according to a conventional preparation method, combining with pharmaceutically acceptable auxiliary materials and matrixes in the medicines, and preparing corresponding oral preparations.

The oral preparation comprises powder, capsule, tablet, pill, granule or soft extract.

The preparation method of the powder comprises the following steps: weighing the raw materials according to a certain proportion, pulverizing into fine powder, and mixing uniformly.

The preparation method of the capsule comprises the following steps: weighing the medicinal materials according to the prescription proportion, adding 6-10 times of water to soak for 0.5-2h, decocting for 2-3 times each time for 1-2h, merging the decoctions, uniformly mixing, concentrating to 80% of the original medicinal liquid, filtering while the hot, concentrating the filtrate to an extract with relative density of 1.15-1.25 at 70 ℃, drying at 70 ℃ to obtain dry extract, pulverizing into fine powder, adding starch slurry with the preparation amount of 10%, granulating, drying, finishing granules, and filling capsules to obtain the traditional Chinese medicine.

The preparation method of the tablet comprises the following steps: weighing the medicinal materials according to the prescription proportion, adding 6-10 times of water to soak for 0.5-2h, decocting for 2-3 times, each time for 1-2h, mixing decoctions, concentrating into 80% of the original medicinal liquid,

filtering while hot, concentrating the filtrate to extract with relative density of 1.20-1.30 at 70deg.C, drying at 70deg.C, pulverizing into fine powder to obtain dry extract, adding 10% dextrin, granulating with 70% ethanol as wetting agent, drying, tabletting, and film coating to obtain tablet.

The preparation method of the granule comprises the following steps: weighing the medicinal materials according to the prescription proportion, soaking for 0.5-2h by adding 6-10 times of water, decocting for 2-3 h each time, mixing decoctions, concentrating into 80% of the original medicinal liquid, filtering while hot, concentrating the filtrate into extract with relative density of 1.20-1.30 at 70 ℃, drying the extract at 70 ℃, pulverizing into fine powder to obtain dry extract, taking 10% sucrose, granulating with 80% ethanol as wetting agent, drying at 60 ℃ after granulating, sieving with 12 mesh sieve for 1 time, and sieving with 60 mesh sieve to obtain the granule.

The preparation method of the granule comprises the following steps: weighing the medicinal materials according to the prescription proportion, adding 6-10 times of water to soak for 0.5-2h, decocting for 2-3 times, each time for 0.5-2h, merging the decoctions, mixing uniformly, concentrating into 80% of the original medicinal liquid, filtering while the medicinal liquid is hot, concentrating the filtrate into extract with relative density of 1.20-1.30 at 70 ℃, adding honey, and stirring uniformly to obtain the soft extract.

Compared with the prior art, the invention has the following beneficial effects:

the traditional Chinese medicine compound for treating acne and the preparation method thereof are prepared from dandelion, fructus forsythiae, bighead atractylodes rhizome, chinese angelica, poria cocos, ligusticum wallichii, radix paeoniae alba, rhizoma alismatis, radix angelicae, almond and platycodon grandiflorum. Radix Scutellariae, fructus Gardeniae, cortex Phellodendri, radix Clematidis (fructus Hordei Germinatus, fructus crataegi, massa Medicata Fermentata), and rhizoma Pinelliae Preparata can also be added; the properties and efficacy of each component are as follows: the herba Taraxaci is dried whole plant of Compositae plant Pu Ying Taraxacum mongolicum hand-Mazz, herba Taraxaci Taraxacum borealisinense Kitam or congeneric plant; digging and removing flowers from spring to autumn when they are initially opened; impurity, cleaning and bitter drying; sweet in taste and cold in nature; enter liver and stomach meridians; has effects of clearing heat and detoxicating, detumescence and resolving hard mass, inducing diuresis and treating stranguria; can be used for treating furuncle, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, pulmonary abscess, acute appendicitis, jaundice due to damp-heat, and stranguria due to heat. Fructus forsythiae is a dried fruit of Forsythia suspensa Forsythia suspensa (thunder.) Vahl belonging to Oleaceae; bitter taste and slightly cold nature; enter the lung, heart and small intestine meridians; has effects of clearing heat and detoxicating, detumescence and resolving hard mass, dispelling wind and heat; can be used for treating carbuncle, scrofula, acute mastitis, erysipelas, wind-heat type common cold, epidemic febrile disease, excessive heat, polydipsia, coma, speckle, and stranguria due to heat. The Atractylodis rhizoma is dry rhizome of Atractylodes macrocephala Atractylodes macrocephala Koidz; digging when the lower part She Kuhuang and the upper part leaves become brittle in winter, removing sediment, drying or sun-drying, and removing fibrous roots; bitter and sweet in taste and warm in nature; spleen and stomach meridian; has the effects of tonifying qi of spleen, eliminating dampness, promoting diuresis, stopping sweat and preventing miscarriage; can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and fetal movement. Angelica sinensis is the dry root of Angelica sinensis Angelica sinensis (Oliv.) Diels of Umbelliferae; digging in the late autumn, removing fibrous roots and silt, bundling into small bundles after water is slightly evaporated, and slowly smoking with smoke; sweet and pungent taste and warm nature; enter liver, heart and spleen meridians; has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel, and relieving constipation; can be used for treating sallow complexion due to blood deficiency, dizziness, palpitation, menoxenia, amenorrhea, dysmenorrhea, abdominal pain due to deficiency-cold, rheumatalgia, traumatic injury, carbuncle, skin ulcer, and constipation due to intestinal dryness; the wine angelica has the effects of promoting blood circulation and dredging channels; can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, traumatic injury. Poria is dry sclerotium of Polyporaceae fungus Poria cocos (Schw.) Wolf; sweet and light in taste and neutral in nature; return to heart, lung, spleen and kidney meridians; has effects in promoting diuresis, eliminating dampness, invigorating spleen, and calming heart; can be used for treating edema, oliguria, phlegm retention, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia. Rhizoma Ligustici Chuanxiong is dried rhizome of Ligusticum chuanxiong Hort Ligusticum chuanxiong Hort of Umbelliferae; digging in summer when the node discs on the stems are obviously protruded and are slightly purple, removing sediment, drying after sun drying, and removing fibrous roots; pungent taste and warm nature; meridian tropism between liver, gallbladder and pericardium; has effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind, and relieving pain; can be used for treating chest pain, hypochondrium pain, traumatic injury, menoxenia, amenorrhea, dysmenorrhea, abdominal pain, headache, and rheumatalgia. Radix Paeoniae alba is dry root of Pall Paeonia lactiflora of Pall of Ranunculaceae; bitter and sour in taste and slightly cold in nature; enter liver and spleen meridians; has effects of nourishing blood, regulating menstruation, astringing yin, suppressing sweating, softening liver, relieving pain, and suppressing liver yang; can be used for treating sallow complexion due to blood deficiency, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb contracture pain, headache and dizziness. The Alismatis rhizoma is dry tuber of Alisma orientale (Sam.) Juzep; digging when stem leaves begin to wither in winter, cleaning, drying, and removing fibrous roots and crude skin; sweet and light in taste and cold in nature. Kidney and bladder meridian; has effects of promoting diuresis, removing dampness, clearing heat, eliminating turbid pathogen, and reducing blood lipid; can be used for treating dysuria, edema, distention, diarrhea, oliguria, dizziness due to phlegm and fluid, stranguria due to heat, and hyperlipidemia. Radix Angelicae Dahuricae is dry root of radix Angelicae Dahuricae Angelica dahurica (Fisch. Ex Hoffm.) or radix Angelicae Dahuricae Angelica dahurica (Fisch. Ex Hoffm.) of Umbelliferae; collecting in summer and autumn She Huangshi, removing fibrous root and silt, and sun drying or low temperature drying; pungent taste and warm nature; the stomach, large intestine and lung channels; has effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifices, eliminating dampness, stopping leukorrhagia, and relieving swelling and pus; can be used for treating common cold, headache, furuncle, bone pain, nasal obstruction, nasal discharge, allergic rhinitis, nasosinusitis, toothache, leukorrhagia, and pyocutaneous disease. The almond is a dried mature seed of mountain apricot Prunus armeniaca l.var. Ansu maxim, siberia apricot Prunus sibirica l, northeast apricot Prunus mandshurica (maxim.) Koehne or apricot Prunus armeniaca l; harvesting ripe fruits in summer, removing pulp and core shells, taking out seeds, and sun-drying; bitter taste and slightly warm nature; the Chinese medicinal composition has small toxicity; lung and large intestine channels; has effects of lowering qi, relieving cough and asthma, loosening bowel to relieve constipation; can be used for treating cough, asthma, chest fullness, excessive phlegm, constipation due to intestinal dryness. Radix Platycodi is dry root of radix Platycodi Platycodon grandiflorum (Jacq.) A.DC; bitter and pungent taste and neutral nature; enter lung meridian; has effects in dispersing lung qi, relieving sore throat, eliminating phlegm, and expelling pus; can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, pulmonary abscess, and pus discharge. The Scutellariae radix is dry root of Scutellariae radix Scutellaria baicalensis Georgi of Labiatae; digging in spring and autumn, removing fibrous root and silt, sun drying, removing coarse skin, and sun drying; bitter taste and cold nature; the lung channel, the gallbladder channel, the spleen channel, the large intestine channel and the small intestine channel; has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing toxic substances, stopping bleeding, and preventing miscarriage; can be used for treating damp-heat, summer-heat, chest distress, emesis, damp-heat distention and fullness, dysentery, jaundice, cough due to lung heat, polydipsia due to high fever, hematemesis, epistaxis, carbuncle, swelling, sore, and fetal movement. The fried gardenia is fried gardenia by a clear frying method; fructus Gardeniae is dried mature fruit of fructus Gardeniae Gardenia jasminoides Ellis of Rubiaceae plant; harvesting when the fruits are ripe and red-yellow for 9-11 months, removing the fruit stalks and impurities, steaming to the upper air or putting the fruits into boiling water for scalding slightly, taking out and drying; bitter in flavor and cold in nature. Return to heart, lung and triple energizer meridians; has effects in purging pathogenic fire, relieving restlessness, clearing away heat and dampness, cooling blood, and removing toxic substances; the external use has the effects of detumescence and pain relief; can be used for treating febrile vexation, jaundice due to damp-heat, stranguria, hematemesis, conjunctival congestion, swelling and pain, and pyocutaneous disease due to pathogenic fire; it is indicated for sprain, contusion and pain. Cortex Phellodendri is dried bark of cortex Phellodendri Phellodendron chinense Schneid of Rutaceae; bitter taste and cold nature; kidney and bladder meridian; has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing steam, removing toxic substances, and treating sore; can be used for treating damp-heat diarrhea, jaundice, dark urine, itching and leukorrhagia, heat stranguria, tinea pedis , bone steaming and fatigue heat, night sweat, spermatorrhea, pyocutaneous disease, swelling and toxin, and eczema. Salted phellodendron bark, cortex Phellodendri, radix Phellodendri, has the effect of nourishing yin to reduce pathogenic fire. Is used for treating night sweat and bone steaming due to yin deficiency and fire excess. Malt is processed product of mature fruit of Hordeum vulgare L of Gramineae by germination and drying; sweet in taste and neutral in nature; spleen and stomach meridian; has effects in promoting qi circulation, resolving food stagnation, invigorating spleen, stimulating appetite, and promoting lactation; can be used for treating dyspepsia, abdominal distention and pain, spleen deficiency, galactostasis, breast pain, female weaning, liver Yu Xie pain, and liver and stomach qi pain; the raw malt has the effects of strengthening spleen and stomach, soothing liver and promoting qi circulation; the fried malt has the effects of promoting qi circulation, promoting digestion and promoting lactation for treating spleen deficiency and anorexia and galactostasis; can be used for treating dyspepsia, and female with weaning; the burnt malt has the effects of promoting digestion and resolving food stagnation; can be used for treating food retention, abdominal distention and pain. Fructus crataegi is processed product of dried mature fruit of fructus crataegi Crataegus pinnatifida Bge or fructus crataegi Crataegus pinnatifida Bge. Var. Major N.E.Br. Of Rosaceae; harvesting in autumn, slicing, drying, parching with clear parching method (general rule 0213) to brown on the surface and yellow brown inside to obtain fructus crataegi; sour and sweet taste, slightly warm nature; spleen, stomach and liver meridian; has effects of resolving food stagnation, invigorating stomach, activating qi-flowing, removing blood stasis, eliminating turbid pathogen, and reducing blood lipid; can be used for treating food stagnation, gastric distention, diarrhea, abdominal pain, blood stasis amenorrhea, puerperal blood stasis, thoracoabdominal pain, chest pain, hernia pain, and hyperlipidemia; the food-digesting and stagnation-removing effects of the scorched hawthorns are enhanced; it can be used for treating food stagnation, diarrhea, and dysentery. The Massa Medicata Fermentata is a yellow brown rectangular block with rough outer surface, yellow brown color, white mold, loose section, yellow brown smell and slight taste; has effects in relieving exterior syndrome; can be used for treating headache due to cold and heat, food stagnation, emesis and fullness. Rhizoma Pinelliae Preparata is processed product of rhizoma Pinelliae; pinellia ternate is a dried tuber of the plant Pinellia ternate Pinellia ternata (thunder.) of the family arisaemaceae; pungent taste and warm nature; spleen, stomach and lung meridian; has effects of eliminating dampness and phlegm; can be used for treating cough and asthma with excessive phlegm, phlegm retention, palpitation, dizziness, and headache.

And (3) square solution:

monarch drug: dandelion and fructus forsythiae; radix Scutellariae.

Fructus forsythiae, which enters lung, heart and gallbladder meridians, has the effects of clearing heat and detoxicating, resolving carbuncles and resolving masses, dispelling wind and dissipating heat, and is good at treating carbuncles and furuncles caused by heat toxin and fire toxin, and is called as "sores and holy medicines"; dandelion is bitter and cold, enters liver and stomach meridians, can clear heat of liver and stomach, can reduce swelling and dissipate nodulation, and can take the theory of treating upper Jiao Ruyu, not light and not easy, and the dandelion is light in texture, moves away upper jiao and is good at clearing heat toxin of muscle and skin striae. For the compatibility with Lian Qiao, it is used to clear up Jiao Lire excessive fire, dissipate nodulation and reduce swelling; baical skullcap root, radix Scutellariae, bitter in flavor, cold in nature, dry in dampness and clear lung heat, is the principal drug for treating acne of wind-heat type in lung channel. The dandelion and the weeping forsythiae capsule are combined as monarch drugs, or combined with the baikal skullcap root as monarch drugs, and the functions of clearing heat, detoxicating and resolving masses, or clearing lung heat, detoxicating and resolving masses are achieved together.

Ministerial drugs: bighead atractylodes rhizome, poria cocos and rhizoma alismatis; angelica, ligusticum wallichii and white paeony root; gardenia jasminoides ellis and phellodendron amurense.

(1) Atractylodis rhizoma, poria, alismatis rhizoma: bai Zhu and Fu Ling are combined, bai Zhu is bitter and sweet in taste and warm in nature, enters spleen and stomach meridians, and can tonify qi to restore spleen and transport, and dry dampness and promote diuresis to remove dampness and eliminate pathogenic factors, so that Bai Zhu is an essential herb for treating spleen deficiency syndrome and also an excellent herb for treating phlegm-fluid retention and edema. Poria is sweet and light and flat, sweet and can tonify, light and can permeate, strengthen body resistance, eliminate pathogenic factors, benefit heart and spleen, promote diuresis and remove dampness, and nourish but not drastic, benefit but not violent, and is an essential herb for strengthening spleen and excreting dampness, and also calm heart and tranquilize mind. Bai Zhu is mainly indicated for spleen strengthening and dampness eliminating, fu Ling is mainly for diuresis and dampness excreting, and two herbs are used together for one healthy and one excreting, so spleen can be healthy, dampness can be removed, swelling can be eliminated, fluid can be removed and all chiggers can be known to be removed. Alismatis rhizoma has sweet and bland taste, and cold property, and has effects of promoting diuresis, removing dampness, clearing heat and detumescence; cold energy removes heat, sweet and bland, excretes dampness, enters kidney and bladder meridians, so it is a good herb for purging fire of kidney and excreting dampness of bladder meridians, and is used to remove urine and damp and dispel heat; with Bai Zhu and Fu Ling, it is combined with Bai Zhu and Fu Ling, and has the actions of strengthening spleen qi, transporting dampness, promoting diuresis and resolving spleen stagnation, causing turbid yin to leak down, and reinforcing and reducing yang to supplement each other, strengthening spleen and removing dampness, and has very good efficacy. The three medicines are combined to treat damp and heat sources caused by spleen deficiency and phlegm retention internal stop, and the monarch drug is used as a first group of ministerial drugs.

(2) Angelica sinensis, ligusticum wallichii and radix paeoniae alba: dang Gui is pungent and sweet in nature and warm in nature, enters liver, heart and spleen meridians, is sweet and tonic and warm in nature, and has the effects of regulating qi and activating blood by replenishing blood, and is known as a holy medicine in blood; it is combined with Bai Zhu to nourish liver blood, regulate qi and blood, tonify spleen qi, promote spleen yang, supplement hardness and softness without stagnation, and is a common herb pair for regulating qi and blood. White peony root has sour and bitter taste, is slightly cold in nature, enters liver and spleen channels, and has the effects of nourishing blood, astringing yin, harmonizing nutrient and softening liver; when being combined with angelica, the angelica is used for replenishing blood to warm yang, the nature of the angelica is moving and mainly walking, the white paeony root is used for replenishing blood to nourish yin, the nature of the white paeony root is static and mainly guarding, and the two drugs are used for cold and warm simultaneously, and the functions of nourishing yin and replenishing blood, regulating liver and spleen, and activating blood and dissolving stasis are combined together, so that the Chinese angelica is mainly used for treating all diseases of deficiency of qi and blood and incoordination between liver and spleen; chuan Xiong is pungent and warm in nature, has the effects of promoting qi circulation, resolving depression, dispelling wind, removing dampness, promoting blood circulation and relieving pain, and can take into account qi and blood stasis, and is an essential herb for both qi and blood. The Chinese angelica and the white peony root are used for replenishing yin by blood herbs, and the hemlock parsley has the effect of promoting blood circulation and removing blood stasis by combining the three herbs. The three auxiliary monarch drugs have the functions of regulating and regulating qi and blood, detoxifying and resolving masses, so the three auxiliary monarch drugs are combined into a second group of ministerial drugs.

(3) Gardenia jasminoides ellis and phellodendron amurense: all are bitter and cold and dry dampness, but acne heat toxin is from triple energizer and phlegm-fluid retention blocks and hinders triple energizer qi transformation, so Zhi Zi can clear heat and dampness of triple energizer and qi movement is smooth, so that monarch drug can clear heat and detoxify. Huang Baiqing with the actions of nourishing yin and clearing heat. In addition, after the gardenia is stir-baked with salt, the phellodendron bark is prevented from being too cold and cool, and the cold is prevented from suppressing heat evil, and the herbs can enter the kidney (lower-jiao) to control fire of lower-jiao. The compatibility of the two herbs can clear the heat of lower energizer and triple energizer to assist the monarch drug, and the combination of the two herbs is the ministerial drug of the third group.

Adjuvant drug: radix Angelicae Dahuricae, semen Armeniacae amarum, and radix Platycodi; hawthorn, malt and Jian qu

Because phlegm-fluid retention is caused by spleen and stomach failing to transport and transform, it also depends on lung failing to disperse and descend, it can block striae and skin and hair, and almond taste is bitter and slightly warm, enters lung and large intestine meridians, and has the action of dispersing lung qi. Ji Geng is bitter and pungent, and pungent in flavor, dispersing lung qi, bitter in flavor, descending qi, ascending and descending, dispersing lung qi, benefiting chest and diaphragm, descending lung qi, eliminating phlegm and expelling pus, and moist in nature, can moisten intestines and relieve constipation. The two herbs are combined, one for lowering one for dispersing lung qi, relieving sore throat and resolving phlegm, and dredging intestines and stomach, and the three herbs are combined for promoting urination and defecation, so that heat toxin and phlegm dampness have the effect of removing pathogenic factors and guiding the pathogenic factors out. Radix angelicae is pungent and warm, can assist the monarch and minister with fragrance to eliminate dampness and dredge blood vessels, and also assist and treat the monarch and minister with the medicine bitter and diarrhea with impairment. Hawthorn fruit, malt and Jianqu can relieve food stagnation of flour food, cereal food and meat food, promote digestion, prevent phlegm-dampness from endogenous sources, and achieve the effects of removing fat and controlling oil. The warm nature of the herbs in this section can be used to monitor the bitter and cold nature of monarch and ministerial drugs, so as to prevent bitter and cold from hurting the healthy energy. So almond, platycodon root, malt and Jian qu are combined as adjuvant drugs.

The preparation method comprises the following steps: radix Platycodi and radix Angelicae Dahuricae are both combined with the guiding herbs because they are guided to the upper Jiao Toumian part and then go upward to the affected part.

In summary, the invention has the effects of clearing heat and resolving drink, strengthening spleen and replenishing qi and harmonizing qi and blood on the basis of pathogenesis of phlegm-fluid and resolving heat, namely spleen deficiency and drink stop, qi and blood disharmony, for female acne with heat toxin accumulated in upper-jiao heads, faces, chest and back. All Fang Hanwen are combined to achieve the purpose of eliminating acne.

Description of the drawings:

fig. 1: the effective rate of treatment;

fig. 2: case 1 pre-treatment picture;

fig. 3: case 1 post-treatment pictures;

fig. 4: case 3 pre-treatment picture;

fig. 5: case 3 post-treatment pictures.

Detailed Description

The invention is further illustrated by the following examples, which are not intended to be limiting.

Example 1:

prescription: 15g of dandelion, 15g of weeping forsythia, 12g of bighead atractylodes rhizome, 9g of angelica, 12g of poria cocos, 9g of ligusticum wallichii, 30g of white peony root, 15g of rhizoma alismatis, 10g of radix angelicae, 10g of almond and 10g of platycodon grandiflorum;

the preparation process comprises the following steps: the preparation method comprises the steps of weighing the traditional Chinese medicines according to a proportion, crushing the traditional Chinese medicines into fine powder, and uniformly mixing the fine powder to obtain the powder.

The usage amount is as follows: one dose is taken every day, 5 days a week, 300ml of boiled water is brewed, 150ml of the filtered solution is taken every morning and evening, and the four weeks are continuous.

Example 2:

prescription: 10g of dandelion, 10g of weeping forsythia, 8g of bighead atractylodes rhizome, 4g of angelica, 8g of poria cocos, 4g of ligusticum wallichii, 10g of white peony root, 10g of rhizoma alismatis, 5g of radix angelicae, 5g of almond, 5g of platycodon grandiflorum and 10g of radix scutellariae;

the preparation process comprises the following steps: weighing the medicinal materials according to the prescription proportion, soaking the medicinal materials in 6 times of water for 0.5h, decocting for 3 times, each time for 2h, combining the three decoctions, uniformly mixing, concentrating to 80% of the original medicinal liquid, filtering while the hot, concentrating the filtrate to extract with relative density of 1.15-1.25 at 70 ℃, drying at 70 ℃ to obtain dry extract, pulverizing into fine powder, adding starch slurry with the preparation amount of 10%, granulating, drying, finishing, and filling into capsules to obtain the capsule.

The usage amount is as follows: 3 times daily, 2-4g once, and is continuously taken for four weeks.

Example 3:

22g of dandelion, 22g of weeping forsythia, 20g of bighead atractylodes rhizome, 16g of angelica, 20g of poria cocos, 16g of ligusticum wallichii, 45g of white peony root, 22g of rhizoma alismatis, 18g of radix angelicae, 18g of almond, 18g of platycodon grandiflorum, 20g of gardenia and 16g of salted phellodendron;

the preparation process comprises the following steps: weighing the medicinal materials according to the prescription proportion, soaking the medicinal materials in 8 times of water for 0.5h, decocting for 2 times, each time for 1h, combining the two decoctions, mixing uniformly, concentrating to 80% of the original medicinal liquid, filtering while the hot, concentrating the filtrate to extract with relative density of 1.20-1.30 at 70 ℃, drying the extract at 70 ℃, pulverizing into fine powder to obtain dry extract, adding 10% dextrin, granulating with 70% ethanol as wetting agent, drying, tabletting, and film coating to obtain the tablet.

The usage amount is as follows: 3 times daily, 2-4g once, and is continuously taken for four weeks.

Example 4:

15g of dandelion, 18g of weeping forsythia, 10g of bighead atractylodes rhizome, 9g of angelica, 12g of poria cocos, 14g of ligusticum wallichii, 25g of white peony root, 10g of rhizoma alismatis, 11g of radix angelicae, 15g of almond, 5g of platycodon grandiflorum, 9g of malt, 12g of hawthorn and 8g of Jian qu;

the preparation process comprises the following steps: weighing the medicinal materials according to the prescription proportion, soaking the medicinal materials in 10 times of water for 0.5h, decocting for 3 times, 1.5h each time, merging the three decoctions, uniformly mixing, concentrating to 80% of the original medicinal liquid, filtering while the hot, concentrating the filtrate to an extract with relative density of 1.20-1.30 at 70 ℃, drying the extract at 70 ℃, pulverizing into fine powder to obtain dry extract, granulating 20% of sucrose with 80% ethanol as a wetting agent, granulating, drying at 60 ℃, sieving with a 12-mesh sieve for 1 time, and sieving with a 60-mesh sieve to obtain fine powder, thus obtaining the granule.

The usage amount is as follows: is administered 3 times daily, 4-6g once, and continuously for four weeks.

Example 5:

20g of dandelion, 20g of weeping forsythia, 16g of bighead atractylodes rhizome, 4g of Chinese angelica, 11g of poria cocos, 5g of ligusticum wallichii, 25g of white peony root, 12g of rhizoma alismatis, 5g of radix angelicae, 10g of almond, 15g of platycodon grandiflorum and 9g of rhizoma pinellinae praeparata;

the preparation process comprises the following steps: the preparation method comprises the steps of weighing the traditional Chinese medicines according to a proportion, crushing the traditional Chinese medicines into fine powder, and uniformly mixing the fine powder to obtain the powder.

The usage amount is as follows: one dose is taken every day, 5 days a week, 300ml of the medicine is brewed with boiled water, 150ml of the medicine is taken every morning and evening, and the medicine is continuously taken for four weeks.

Example 6:

10g of dandelion, 10g of weeping forsythia, 12g of bighead atractylodes rhizome, 14g of angelica, 16g of poria cocos, 5g of ligusticum wallichii, 20g of white peony root, 15g of rhizoma alismatis, 15g of radix angelicae, 6g of almond, 8g of platycodon grandiflorum, 15g of radix scutellariae, 12g of gardenia and 8g of salted phellodendron;

the preparation process comprises the following steps: weighing the medicinal materials according to the prescription proportion, soaking the medicinal materials in 6 times of water for 0.5h, decocting for 3 times, each time for 2h, combining the three decoctions, uniformly mixing, concentrating to 80% of the original medicinal liquid, filtering while the hot, concentrating the filtrate to extract with relative density of 1.15-1.25 at 70 ℃, drying at 70 ℃ to obtain dry extract, pulverizing into fine powder, adding starch slurry with the preparation amount of 10%, granulating, drying, finishing, and filling into capsules to obtain the capsule.

The usage amount is as follows: 3 times daily, 2-4g once, and is continuously taken for four weeks.

Example 7:

prescription: 15g of dandelion, 15g of weeping forsythia, 12g of bighead atractylodes rhizome, 9g of angelica, 12g of poria cocos, 9g of ligusticum wallichii, 30g of white paeony root, 15g of rhizoma alismatis, 10g of radix angelicae, 10g of almond, 10g of platycodon grandiflorum, 15g of radix scutellariae, 10g of gardenia, 9g of salted phellodendron, 9g of malt, 9g of hawthorn, 9g of starter propagation and 9g of rhizoma pinellinae praeparata;

the preparation process comprises the following steps: weighing the medicinal materials according to the prescription proportion, soaking in 8 times of water for 0.5h, decocting for 2 times, each time for 1h, mixing the two decoctions, mixing, concentrating to 80% of the original medicinal liquid, filtering while hot, concentrating the filtrate to extract with relative density of 1.20-1.30 at 70deg.C, adding Mel, and stirring to obtain soft extract.

The usage amount is as follows: 3 times daily, 2-4g once, and is continuously taken for four weeks.

In order to verify the beneficial effects of the invention, the inventor performs relevant clinical experiments and experimental researches, and the experimental process and results are as follows:

1 clinical trial

1.1 case Source

Cases were from women acne patients who were diagnosed at a first affiliated hospital of the Guizhou university of traditional Chinese medicine (also known as Guizhou Miao), from 2021, 04, to 2022, 01, and the serum control group was healthy women who were reading at Guizhou university of traditional Chinese medicine during the study period. The final test group recorded 35 patients, dropped, removed 5, completed 30, and the serum control group completed 10. The difference in age distribution between the two groups of subjects tested was not statistically significant (P > 0.05).

1.2 diagnostic criteria

1.2.1 Western diagnostic criteria

The diagnosis standard for AV in the clinical dermatology written by Western medicine diagnosis standard reference Zhao Bian is preferably applied to teenagers, and is mainly characterized by black and white comedones and inflammatory papulopustules. The severity score for acne was graded using a grade 12 Cunliffe scale.

1.2.2 Chinese medicine differentiation and typing Standard

The differentiation and typing standard is prepared by referring to clinical experience and combining literature progress: (1) spleen deficiency fluid retention and (or) qi-blood disharmony: pale complexion or sallow complexion, preference for calm and lazy movement, tender flesh, cold limbs, chest distress and anorexia, thin stool, thirst, anorexia, greasy complexion, and thin and white leucorrhea. The tongue body is fat and has teeth marks on the side, and the tongue surface is lubricated. A pale or dull tongue. Thick or greasy coating. The pulse is deep, thin, wiry or slippery; pale complexion, dizziness, palpitation, dreaminess, cold ends, dry skin, irregular menstruation (stage of derivation, less amount of menstruation, dysmenorrhea, amenorrhea). A pale or dull tongue. The pulse is deep, thin and weak. (2) Heat toxin accumulating in skin: acne with pimple red; or with painful nodules, or with multiple pustules, even cysts; can be accompanied with thirst, and the rash is obviously aggravated after eating pungent and thick flavor or after staying up night, the tip of the tongue is red, and the tongue coating is yellow. Meanwhile, the syndrome of item (1) and (2) can be identified as the principal syndrome.

1.3 inclusion criteria

(1) Meets the diagnosis standard of acne vulgaris of Western medicine, and the grade is the first 7 patients by a Cunliffe grading method;

(2) meets the diagnosis standard of the spleen deficiency and fluid retention, qi-blood disharmony and heat toxin accumulation skin syndrome of the traditional Chinese medicine;

(3) women aged 18-45 years;

(4) the clinical test is voluntarily added, the requirement of the test is complied with, and the patient can take the medicine according to the doctor's advice to finish the test;

(5) each subject needs to take a photograph and cooperate to fill in the traditional Chinese medicine syndrome scoring table before treatment and sign an informed consent.

1.4 exclusion criteria

(1) Women in gestational lactation;

(2) acne resulting from the application of chemicals or pharmaceuticals;

(3) patients with serious primary diseases and mental diseases such as cardiovascular, cerebrovascular, liver, kidney and hematopoietic system;

(4) drugs for treating acne such as retinoic acid, spironolactone, tanshinone, and Chinese medicine are taken in the last month;

(5) other facial diseases affecting the observation of efficacy.

1.5 drop and reject criteria

(1) Failure to complete a course of treatment or failure to cooperate with a therapist;

(2) terminating the tester due to serious adverse drug reactions;

(3) patients who are not in compliance with the medical advice in the treatment process.

1.6 method

Subjects meeting the standard were divided into A, B two groups (group a is the test group and group B is the serum control group) group a were subjected to the following interventions on the basis of treatment, group B was only serum control, and no other interventions were performed:

(1) Group a (test group):

1) Decoction for oral administration for resolving food stagnation and treating acne (the primary name of the recipe is simply called "acne-clearing decoction")

The composition is as follows:

15g of dandelion, 15g of weeping forsythia, 12g of bighead atractylodes rhizome, 9g of angelica, 12g of poria cocos, 9g of ligusticum wallichii, 30g of white peony root, 15g of rhizoma alismatis, 10g of radix angelicae, 10g of almond and 10g of platycodon grandiflorum;

adding, subtracting and cutting: radix Scutellariae 15g is added for patients with rash and cheek diseases; for those with rash and chin and mandible as main ingredients, fructus Gardeniae 10g and cortex Phellodendri 9g are added; facial greasiness: adding 9g of Sanxian (Sanxian, namely malt, hawthorn and Jian qu); rhizoma Pinelliae 9g is added to treat thick and greasy fur.

(1) The usage amount is as follows: one dose is taken every day, 5 days a week, 300ml of the medicine is brewed with boiled water, 150ml of the medicine is taken every morning and evening, and the medicine is continuously taken for four weeks.

2) Basic treatment (all recommended conventional treatment regimens for clinical professional guidelines/expert consensus):

(1) improved reverse powder for external use of I'm department with optimized proportion through research

The composition is as follows: crushing (powder preparation) rhubarb and sulfur in a ratio of 2:1 by an SF-400 type high-speed crusher (type I)

The usage amount is as follows: after face cleaning before sleeping, taking out the powder of the powder inversion, placing the powder into a cup, heating boiled water (the ratio of the powder to the boiled water is 1:1.5), fully and uniformly mixing the powder into paste (the degree that the powder is smeared on the back of the hand and does not drip), cooling the powder, externally applying the powder to the skin damage area with the thickness of about 2-3mm, scraping the medicine after 25 minutes, and cleaning the face with clean water once per night.

(2) Powder pricking needle picking and treating device

If the patient has skin lesions such as acne and pustule, acne and inflammatory secretion can be removed by sterilizing the acne needle.

(2) Group B (serum control group)

The serum control group was intended to select 30 healthy women without acne and to draw blood to measure hormone levels during 2-4 days of menstrual period.

1.7 observations index

(1) Test group: patient age, course of disease, skin lesion severity; scoring the traditional Chinese medicine symptoms and skin damage; serum hormone levels: DHEA and DHEA-S, IGF-1.

(2) Serum control group: age, DHEA-S, IGF-1 hormone levels.

1.8 efficacy assessment criteria

The preparation is formulated by referring to the main code of "New Chinese medicine clinical research guidelines for treatment" in 2002, zhengyu.

(1) The calculation formula is as follows:

efficacy index (%) = [ (pre-treatment integral-post-treatment integral)/pre-treatment integral ] ×100%.

Total effective rate (%) = [ (recovery + onset + efficacy)/total case number ] ×100%.

(2) Criterion for skin damage therapeutic effect

(1) The skin rash completely subsides, and only pigmentation and scar remain.

(2) Has obvious effect that the rash is resolved by more than 70 percent or the severity is reduced by more than 2 degrees.

(3) The effective rate is that the rash is resolved by more than or equal to 70 percent and more than 30 percent, or the severity is reduced by more than 1 degree, and new skin lesions still appear.

(4) Ineffective, rash resolved <30%, or aggravated.

1.9 statistical methods

The statistical method of the research adopts SPSS25.0 statistical software to carry out statistical analysis, and the hormone level, skin damage score and traditional Chinese medicine syndrome score of the patients in the test group before and after treatment adopt paired t test or accord with rank sum test; t test or rank sum test of independent samples is adopted in comparison between groups; and (3) aiming at the research of curative effect influence factors, taking the obvious effect as a positive event, and adopting two classification logistic regression analysis.

2 results

2.1 statistics of treatment effectiveness

The total effective rate of the test group is 90%, the average curative effect index is 55.42%, and the obvious effective rate is 33.33%, as shown in figure 1.

2.2 analysis of hormone levels in the Pre-treatment two groups

TABLE 1 analysis of DHEA and DHEAS levels in the Pre-treatment and serum control groups of the test group

TABLE 2 analysis of IGF-1 levels in the test and serum control groups prior to treatment

According to tables 1, 2: the test group has statistical significance (P is less than 0.05) in comparison of the levels of DHEA and DHEA-S, IGF-1 in the blank control group, and the level of the three hormones in the test group is higher than that in the normal group.

2.3 analysis of scores of DHEA, IGF-1, DHEA-S and traditional Chinese medical Condition and skin lesions before and after treatment of the test group

Table 3 DHEA analysis before and after treatment of the test group

TABLE 4 analysis of IGF-1, DHEA-S and traditional Chinese medical Condition score and skin lesion score before and after treatment in the test group

According to tables 3 and 4, the comparison of the DHEA, DHEA-S, IGF-1 and the traditional Chinese medicine syndrome score and the skin damage score analysis level has statistical significance (P is less than 0.05), and each hormone level and skin damage score of the patient after treatment are reduced compared with those before treatment.

Discussion 3

The common acne is clinically common damage-tolerant disease, and the inventor discovers that female acne patients commonly have deficiency-excess mixed cold-heat mixed symptoms for more than ten years and the series of symptoms are coagulated to form spleen deficiency and fluid retention, qi-blood disharmony and heat toxin accumulation skin symptoms; the traditional Chinese medicine composition is characterized by being beautiful and diet-saving, and the symptoms of listlessness, weakness, abdominal pain, anorexia, loose stool, spleen yang, deficiency of spleen yang, weak food essence, and deficiency of qi and blood are all seen in the prior art, and the symptoms of pale complexion, dizziness, weakness, insomnia, dreaminess, small menstruation and the like are seen. Yang Xumo the face is acne when the head is fumigated by damp-heat. Syndrome differentiation refers to spleen deficiency with retention of fluid, qi and blood disharmony and heat toxin accumulation in the skin, so it is applied to the treatment of fluid retention and serum acne decoction (the name of this preliminary name is abbreviated as "acne-clearing decoction").

For the research on the occurrence of acne, the major mechanism of the hormone level is considered to influence the secretion of sebaceous glands and the keratinization process of the sebaceous glands, and a specific mechanism is reported to be that the mechanism of promoting lipid synthesis by androgen is mainly that after the androgen is combined with an intra-sebaceous AR receptor, the phosphorylation level of mTOR is increased, so that the occurrence of a rapamycin target C1 pathway (mTORC 1) of a mammal is promoted, and a sterol regulatory element binding protein-1 (SREBP-1) is activated, so that the synthesis and secretion of lipid are promoted. Androgens can also induce differentiation of sebaceous gland cells by modulating Wnt/β -catenin pathway, and the differentiated sebaceous gland cells can exhibit high level AR, thereby promoting accumulation of lipids. In addition to the effects of T and DHT on this disease, studies have shown that DHEA and DHEA-S are also involved in the pathogenesis of acne, as they are converted to T and DHT as androgen precursors. It follows that the levels of DHEA and DHEA-S have a definite effect on the levels of T and DHT in sebocytes, and that the use of DHEA-based drugs has been reported to have definite adverse effects leading to acne. Kling CM and the like have proposed that peripheral metabolism of DHEA is a major contributor to circulating hormone levels in women, and 40% -75% of testosterone levels in pre-menopausal women are converted from DHEA, from which it can be speculated that levels of DHEA and DHEA-S are significant for female acne, and studies have demonstrated this. Whereas recent Meta analysis of the effects of DHEA on human insulin growth factor-1 (IGF-I) by Xie Ming et al suggests that supplementation with DHEA increases serum IGF-I levels, particularly in female subjects. IGF-I is also an important factor in the development of acne inflammation. Studies show that the sleep deficiency can cause insulin resistance, so that insulin secretion is increased, the promotion effect of the insulin on androgens is enhanced, the insulin also has definite effect of promoting IGF-1 production, and IGF-1 has the effects of promoting skin keratinocyte proliferation and androgenesis; wherein the androgen-production-promoting mechanism inhibits T-to-E2 by inhibiting androgen receptor signaling, indirectly leading to increased DHT; in addition, it can stimulate sebaceous gland cell proliferation, promote sebum synthesis and inflammatory factor generation. The clinical application of the prescription finds that the therapeutic effect is particularly good for female patients, and the prescription has definite hormone-like effect on the hormone level of DHEA, IGF-1 and DHEA-S, so the influence observation of the prescription on the hormone level of DHEA, IGF-1 and DHEA-S is developed.

In the results, the present formula may have mechanisms for regulating and controlling the IGF-1, DHEA and DHEA-S hormone levels, so that sebum secretion, keratinization of a follicular duct and inhibition of inflammatory factor release are indirectly regulated and controlled to achieve the treatment purpose, and particularly, a way and a target point for regulating and controlling the therapeutic effect need to be further explored.

4 clinical cases

Case 1:

wang Mou female, 25 years old, facial repeated rash accompanied with pain for 5 years, severe half month, facial multiple red pimple, acne and nodule, small amount of cyst, pustule at part of papule top, obvious tenderness, obvious pus and pus suppository acne overflow after extrusion, see fig. 2;

etiology of patient: the face gradually appears to be multi-divergent in pimple and red with tenderness before 5 years, powder fat-filled substances are extruded by hands to overflow and partially take the form of rice grain-shaped semitransparent particles, the doctor can ask for help from multiple prescriptions, the doctor can temporarily improve the skin rash by external wiping of vitamin A acid cream, external application of adapalene gel, external wiping of fusidic acid and the like, but the skin rash is always present, repeatedly aggravated with a small quantity of pustules, and the curative effect of oral minocycline and doxycycline is still not obvious. The rash is gradually increased before half month, the rash is bright red, pustules appear at partial top, pus overflows by squeezing with hands, and the skin rash is obviously painful, cold hands and feet and bitter taste. Plain menstrual disorder, less menstruation, aversion to cold, loose stool, dizziness, palpitation, insomnia, pale tongue, enlarged tongue body, tooth trace on the side of the tongue, watery tongue with white and greasy coating, deep and wiry pulse, and floating and rapid pulse;

family history: the father had severe acne, leaving a pit or scar on his face.

Diagnosis:

diagnosis of traditional Chinese medicine: acne [ heat toxin accumulated in the skin, spleen deficiency and fluid retention ]. Western diagnosis: acne vulgaris.

Prescription:

the traditional Chinese medicine is taken orally: 18g of dandelion, 20g of weeping forsythia, 12g of bighead atractylodes rhizome, 9g of angelica, 18g of poria cocos, 9g of ligusticum wallichii, 30g of white peony root, 15g of rhizoma alismatis, 10g of radix angelicae, 10g of almond and 10g of platycodon grandiflorum;

the using method comprises the following steps: decocting with water for oral administration, one dose per day (taken in three times);

and (5) re-diagnosis: after 10 days of continuous administration, the rash is obviously improved, the pustules are resolved, and the pain is obviously relieved. Palpitation and insomnia disappear, hands and feet are warmer than before, and bitter taste disappears.

Review prescriptions: the traditional Chinese medicine is taken orally: 18g of dandelion, 20g of weeping forsythia, 12g of bighead atractylodes rhizome, 9g of angelica, 18g of poria cocos, 9g of ligusticum wallichii, 30g of white peony root, 15g of rhizoma alismatis, 10g of radix angelicae, 10g of almond and 10g of platycodon grandiflorum;

the using method comprises the following steps: orally administered, one dose per day (taken in three times);

and re-diagnosis is carried out after the medicine is continuously taken for 10 days: the papules, nodules, cysts and pustules all resolve, no pain is felt, only the face has acne marks, pigmentation, palpitation and insomnia disappear, hands and feet are warmer than before, and the bitter taste disappears, as shown in figure 3.

Case 2:

cheng Mou A20 year old female, recurrent facial inflammatory papules, pustules for 1+ years, sallow complexion, four reversals, anorexia, loose stool, greasy complexion, enlarged tongue with teeth marks on the sides, lubricated tongue with pale tongue, thick and greasy coating, deep and slippery pulse, perioral inflammatory papules, pustules, brown crusta crust, partial fusion, cheek acne marks and pigmentation;

etiology of patient: papules, pustules, severe mouth Zhou You, pain caused by contact, and the like on the face during the period of 1+ years, the external medicine is purchased for self-use, and the skin damage is resolved after use, but any recurrent attacks are not diagnosed by the system, and the skin damage is aggravated during the period of time or the period of time after the night;

diagnosis:

diagnosis of traditional Chinese medicine: acne [ heat toxin accumulated in the upper part, spleen deficiency and fluid retention syndrome ], western diagnosis, acne;

prescription: the traditional Chinese medicine is taken orally: 10g of dandelion, 20g of weeping forsythia, 10g of angelica, 20g of white peony root, 20g of poria cocos, 10g of bighead atractylodes rhizome, 10g of rhizoma alismatis, 12g of ligusticum wallichii, 10g of platycodon grandiflorum, 6g of radix angelicae, 10g of almond, 20g of gardenia, 12g of salted phellodendron, 18g of radix scutellariae, 10g of malt, 10 of Jian yeast, 10 of hawthorn and 10g of rhizoma pinellinae praeparata;

the using method comprises the following steps: orally administered, one dose per day (taken in three times);

after 10 days of continuous administration, the inflammatory papules on the face are regressed, the mouth Zhou Qiuzhen and the pustules are obviously improved, more acne marks, pigmentation and dysmenorrhea are relieved.

Review prescriptions: the traditional Chinese medicine is taken orally: 20g of dandelion, 20g of weeping forsythia, 10g of angelica, 30g of white peony root, 10g of poria cocos, 20g of rhizoma alismatis, 6g of ligusticum wallichii, 10g of bighead atractylodes rhizome, 20g of gardenia, 12g of salted phellodendron bark, 18g of radix scutellariae, 10g of starter propagation, 10g of malt, 10g of hawthorn, 10g of platycodon grandiflorum, 10g of almond and 6g of radix angelicae;

the using method comprises the following steps: orally administered, one dose per day (taken in three times);

after further administration for 10 days, the inflammatory papules on the face regress, the mouth Zhou Qiuzhen and the pustules regress, the face has acne marks and pigmentation, and the dysmenorrhea does not exist.

Case 3:

yang Mou the female, 23 years old, repeated facial inflammatory papules 1+ years, sallow complexion, cold limbs, greasy skin, anorexia, sleepiness, pale tongue with greasy coating, smooth tongue surface, slippery pulse, red papules on the face, acne marks, pigmentation;

etiology of patient: there was no obvious cause of red pimple on the face before 1+ years, with pus spots, pain due to touch, the self-purchasing of fusidic acid cream was external, the rash was improved during use, the improvement of rash was not obvious after long-term use, and after that, each time was aggravated by staying up at night, having a large pressure or menstrual period, see fig. 4;

diagnosis: diagnosis of traditional Chinese medicine: acne [ pattern of heat-toxin accumulation and spleen-deficiency retention ]. Western diagnosis: acne.

Prescription: the traditional Chinese medicine is taken orally: 20g of dandelion, 15g of weeping forsythia, 10g of angelica, 10g of white peony root, 10g of poria cocos, 10g of bighead atractylodes rhizome, 10g of rhizoma alismatis, 10g of ligusticum wallichii, 18g of baical skullcap root, 12g of salted phellodendron bark, 10g of hawthorn, 10g of starter propagation, 10g of malt, 12g of platycodon root, 10g of almond, 10g of angelica dahurica, 9g of gardenia and 9g of rhizoma pinellinae praeparata;

the using method comprises the following steps: orally administered, one dose per day (taken in three times);

after taking the medicine continuously for 10 days, the patient is re-diagnosed, the inflammatory papule of the face is obviously improved, the facial powder is red papule, the diet is better, the complexion is light yellow, the four adverse effects are avoided, the sleep is still good, the T-shaped area of the skin is greasy, the patient can get the tongue fat, the patient has tooth marks on the side, the tongue surface is smooth, the tongue is light, the tongue coating is slightly greasy, and the pulse is slippery.

Review prescriptions: the traditional Chinese medicine is taken orally: 20g of dandelion, 12g of weeping forsythia, 10g of angelica, 10g of white peony root, 10g of poria cocos, 10g of bighead atractylodes rhizome, 10g of rhizoma alismatis, 12g of salted phellodendron bark, 10g of malt, 10g of ligusticum wallichii, 18g of baical skullcap root slices, 10g of hawthorn, 10g of Jianqu, 12g of platycodon grandiflorum, 10g of radix angelicae, 10g of almond and 10g of gardenia;

the using method comprises the following steps: orally administered, one dose per day (taken in three times);

after another 10 days of continuous administration, the inflammatory papules on the face subsided, and the face had a small number of acne marks and a pale pigmentation, see fig. 5.

Claims (9)

1. A Chinese medicinal preparation for treating female acne is characterized in that: the medicinal active ingredients are calculated according to the weight components: is prepared from 130-170 parts of dandelion, 130-170 parts of weeping forsythia, 100-140 parts of bighead atractylodes rhizome, 70-110 parts of angelica, 100-140 parts of poria cocos, 70-110 parts of ligusticum wallichii, 200-400 parts of white peony root, 130-170 parts of rhizoma alismatis, 80-120 parts of radix angelicae, 80-120 parts of almond and 80-120 parts of balloonflower root.

2. The traditional Chinese medicine preparation for treating female acne according to claim 1, wherein: the medicinal active ingredients are calculated according to the weight components: is prepared from 150 parts of dandelion, 150 parts of weeping forsythia, 120 parts of bighead atractylodes rhizome, 90 parts of Chinese angelica, 120 parts of poria cocos, 90 parts of ligusticum wallichii, 300 parts of white peony root, 150 parts of rhizoma alismatis, 100 parts of radix angelicae, 100 parts of almond and 100 parts of orange stems.

3. The traditional Chinese medicine preparation for treating female acne according to any one of claims 1 or 2, characterized in that: the acne patient has rash with cheek, and 100-220 parts of radix Scutellariae is added in the prescription.

4. The traditional Chinese medicine preparation for treating female acne according to any one of claims 1 or 2, characterized in that: the acne patient has rash with chin and lower jaw as main part, and fructus Gardeniae 50-200 parts and cortex Phellodendri 40-160 parts are added.

5. The traditional Chinese medicine preparation for treating female acne according to any one of claims 1 or 2, characterized in that: the acne patient has thick greasy coating, and 40-160 parts of rhizoma pinellinae praeparata is added in the prescription.

6. The traditional Chinese medicine preparation for treating female acne according to any one of claims 1 or 2, characterized in that: the acne patient has greasy face, and 40-160 parts of malt, 40-160 parts of hawthorn and 40-160 parts of Jian qu are added in the prescription.

7. A method for preparing a traditional Chinese medicine preparation for treating female acne according to any one of claims 1-6, characterized in that: all the medicinal materials are weighed according to the proportion, processed according to the conventional preparation method, combined with pharmaceutically acceptable auxiliary materials in the medicament, and prepared into corresponding oral preparations.

8. The method for preparing the traditional Chinese medicine compound for treating female acne according to claim 7, which is characterized in that: the oral preparation comprises powder, capsules, tablets, pills, granules or soft extract.

9. The method for preparing the traditional Chinese medicine compound for treating female acne according to claim 8, which is characterized in that: the preparation method of the powder comprises the following steps: weighing the raw materials according to a certain proportion, pulverizing into fine powder, and mixing uniformly.