CN103599406B - A kind of Chinese medicine for climacteric syndrome - Google Patents
A kind of Chinese medicine for climacteric syndrome Download PDFInfo
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- CN103599406B CN103599406B CN201310496727.9A CN201310496727A CN103599406B CN 103599406 B CN103599406 B CN 103599406B CN 201310496727 A CN201310496727 A CN 201310496727A CN 103599406 B CN103599406 B CN 103599406B
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Abstract
A kind of Chinese medicine for climacteric syndrome, relate to field of Chinese herbal medicine technology, be made up of the crude drug of following weight: Semen Cassiae 14-16 gram, Fructus Tritici Levis 19-21 gram, Herba Epimedii 11-13 gram, peninjau gardenia 11-13 gram, Massa Medicata Fermentata 19-21 gram, Rhizoma Cyperi 11-13 gram, Fructus Akebiae 11-13 gram, Olibanum 11-13 gram, Semen Nelumbinis 9-11 gram, Semen Euryales 19-21 gram, Ramulus Mori 14-16 gram, Herba Dendrobii 14-16 gram, Cortex Albiziae 14-16 gram, Caulis Polygoni Multiflori 29-31 gram, Radix Glycyrrhizae 8-10 gram, Fructus Jujubae 14-16 gram.The present invention combines clinical practice for many years to develop on the basis of Traditional Chinese Medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.All medicines amount to the effect having liver and kidney tonifying, nourish heart, calm the nerves mutually, and treatment climacteric syndrome has the high and feature such as to have no side effect of determined curative effect, instant effect, cure rate.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of Chinese medicine for climacteric syndrome.
Background technology
Climacteric refers to that women progresses into senile transition period from period of sexual maturity, comprises premenopause, menopause and postmenopause.Menopause refers to that menstruation stops more than 1 year completely, and the age of physiological menopause, this period, due to hypo-ovaria, disappearance, often caused series of symptoms between 45-55 year.Climacteric women about 1/3 reaches new balance and no conscious sympton by neuroendocrine self regulation.2/3 can there is the symptom caused by the minimizing of a series of gonadal hormone, be called climacteric syndrome.Main clinical manifestation is hectic fever, perspiration, nervousness, emotional instability, and Incidence of CHD increases, osteoporosis, is easy to fracture, aedoeatrophia, vaginal dryness, menoxenia etc.The primary disease traditional Chinese medical science is called " before and after menopause all diseases ", its morbidity is relevant with specific age level, the traditional Chinese medical science is thought " years of seventy-seven ", kidney qi degradation, and menses gradually exhausts, it is the normal physiological change of women, but due to the impact of ferritic difference and living environment etc., the physiology transition in this stage can not be adapted to, and make yin and yang 2 Qi uneven, internal organs QI and blood is not in tune, occurs a series of syndrome.Primary disease is to suffer from a deficiency of the kidney, and clinical syndrome differentiation can be divided into deficiency of the kidney yin and insufficiency of kidney-YANG two
Current western medical treatment primary disease there is no specific medicament, and traditional Chinese medical herbal treatment primary disease has definite curative effect.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of effective, the safe and reliable Chinese medicine for climacteric syndrome.
Technical problem to be solved by this invention realizes by the following technical solutions:
For a Chinese medicine for climacteric syndrome, be made up of the crude drug of following weight,
Semen Cassiae 14-16 gram, Fructus Tritici Levis 19-21 gram, Herba Epimedii 11-13 gram, peninjau gardenia 11-13 gram, Massa Medicata Fermentata 19-21 gram, Rhizoma Cyperi 11-13 gram, Fructus Akebiae 11-13 gram, Olibanum 11-13 gram, 9-11 gram, Semen Nelumbinis (coring), Semen Euryales (shelling) 19-21 gram, Ramulus Mori 14-16 gram, Herba Dendrobii 14-16 gram, Cortex Albiziae 14-16 gram, Caulis Polygoni Multiflori 29-31 gram, Radix Glycyrrhizae 8-10 gram, Fructus Jujubae 14-16 gram.
Preferred weight part of each crude drug is:
Semen Cassiae 15 grams, Fructus Tritici Levis 20 grams, Herba Epimedii 12 grams, peninjau gardenia 12 grams, Massa Medicata Fermentata 20 grams, Rhizoma Cyperi 12 grams, Fructus Akebiae 12 grams, Olibanum 12 grams, 10 grams, Semen Nelumbinis (coring), Semen Euryales (shelling) 20 grams, Ramulus Mori 15 grams, Herba Dendrobii 15 grams, Cortex Albiziae 15 grams, Caulis Polygoni Multiflori 30 grams, 9 grams, Radix Glycyrrhizae, 15 grams, Fructus Jujubae.
Crude drug used by the present invention can be bought from common Chinese shop and obtain, and its specification meets national Chinese crude drug standard.
Another object of the present invention is to provide a kind of method preparing the present composition, comprises the steps,
1) each taste crude drug is taken by weight described in prescription;
2) by above-mentioned each taste crude drug pulverization, incapsulate.
1, pharmacology analysis:
Semen Cassiae: purging liver-fire, yin nourishing improving eyesight, hypertension and hyperlipemia.
Fructus Tritici Levis: " modern Practical Chinese medicinal ": reinforcing the heart, only tired, heat extraction, arresting sweating, diuresis.
Herba Epimedii: kidney invigorating and YANG supporting; Expelling wind and removing dampness; Strong muscle key bone.
Fructus Gardeniae: control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, conjunctival congestion, pharyngalgia, spit blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.
Massa Medicata Fermentata: for the medicines such as Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum add flour or wheat bran mixed after, through the herbal leaven of fermentation.Invigorating the spleen and regulating the stomach, helps digestion in adjusting.Control retention of food and drink, feeling of stuffiness in chest abdominal distention, vomiting dysentery, postnatal blood stasis is suffered from abdominal pain, and children's's enlarged abdomen heavily fortified point is long-pending.
Rhizoma Cyperi: resolving depression of regulating the flow of vital energy; Menstruction regulating and pain relieving.
Fructus Akebiae: liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.
Olibanum: regulating qi and activating blood, analgesic therapy, chases after poison.
Semen Nelumbinis: clear away heart-fire and be amusing, spleen reinforcing antidiarrheal, tranquilizing by nourishing the heart improving eyesight, invigorating middle warmer are reposed, and stomach is mended in spleen invigorating, antidiarrheal controlling nocturnal emission with astringent drugs, kidney tonifying relieving leukorrhea by astringents, nourishing vigour.
Semen Euryales: nature and flavor are sweet flat, nontoxic, invigorating the spleen and replenishing QI, for nourishing robustness food.
Ramulus Mori: " book on Chinese herbal medicine is new again ": strong lung qi, dampness, kidney nourishing water, stimulates the menstrual flow, cough-relieving relieving restlessness, reducing swelling and alleviating pain.
Herba Dendrobii: control consumption of body fluid caused by febrile disease, xerostomia excessive thirst, after being ill deficiency-heat, the moon hinders order secretly, except deficiency-heat, will of calming the nerves.
Cortex Albiziae: cure mainly irritability, melancholy insomnia, lung abscess, carbuncle, scrofula, injured bone.
Caulis Polygoni Multiflori: cure mainly insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.
Radix Glycyrrhizae: heat-clearing and toxic substances removing, nourishing the lung to arrest cough, coordinating the actions of various ingredients in a prescription.
Fructus Jujubae: there is the effects such as tonify deficiency QI invigorating, nourishing blood to tranquillize the mind, invigorating the spleen and regulating the stomach.
2, usage and consumption:
The dosage of medicine of the present invention depends on concrete dosage form, and the factor such as the age of patient, body weight, health status.
Instruction: each 6, every day 3 times, the morning, noon and afternoon take, and a course for the treatment of is 1 month.
3, the present composition has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals and disease therapy, drops into the use link of disease therapy provide science and objective foundation to this medicine.
Its test method and result of the test are distinguished as follows:
1) animal acute toxicity test is carried out to capsule prepared by the present invention:
Medicine: the crude drug used by the present invention is bought from common Chinese shop and obtained, and its specification meets national Chinese crude drug standard.
Experimental animal: white mice, body weight is at about 50g, and male and female Stochastic choice, is bought by market.
Method and result: get white mice 30, hungry 20 hours, feeding 50g by filling with several times every every day, feeding one week continuously, observing 10 days, and mice is movable normal, non-toxic reaction, without dead.Show that oral liquid is without acute toxicity, clinical medicine dose safety.
2) long-term toxicity test for animals is carried out to capsule prepared by the present invention:
Experimental animal: rat, body weight is at 120-130g, and male and female Stochastic choice, is bought by market.
Method and result: get rat 20, be divided into 2 groups, often organize 10, wherein the 1st group as administration group, 40-50g is fed by filling with several times every every day, 2nd group of diet as a control group, once a day, continuous irrigation is fed 90 days, survey body weight, 24 hours sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the change of tissues observed form, observe the effect of dosage, observe diet, movable change, experiment proves that administration group compares without significant change with matched group, equal non-toxic reaction, a kind of safe drugs.
4, diagnostic criteria
1) clinical diagnosis: menoxenia, palpitation and insomnia, weak, depressed, worry too much, the symptoms such as emotional instability.
2) in order to verify clinical efficacy, this prescription is tried out in Jieshou City, Anhui Province institute of traditional Chinese medicine, and random selecting is 50 routine Women’s climacteric patients wherein.
3) Therapeutic Method: take capsule of the present invention, divides for each person every day and takes for three times, one time 6, take 1 month continuously.
4) efficacy determination:
Recovery from illness: warm the symptoms such as sweating, cardiopalmus, abnormal emotion-thought, insomnia and all disappear, not because of angry or tired recurrence.
Effective: warm, sweating, the transference cure such as agitation, feel comfortable;
Effective: to warm, sweating, the symptom such as agitation alleviate, time have overworked or direct stimulation after occur that agitation is not peaceful, excited, but symptom is lighter;
Invalid: after taking medicine, the state of an illness is unchanged.
Concrete therapeutic outcome is see table 1;
Table 1
| Number of cases | Recovery from illness | Effective | Effectively | Invalid | Effective percentage (%) |
| 50 | 5 | 25 | 18 | 2 | 96 |
5, points for attention:
1. diet should be light, gives up alcohol and pungent, raw and cold, greasy food.
2. child, women breast-feeding their children, elderly and infirm should take under doctor instructs.
3. driver, work high above the ground person are cautious use of.
4. strictly take by usage and dosage.
5. pair this medicine and alcohol intolerance person forbidding, allergic constitution person be cautious use of.
6. prohibit the use when this property of drug changes.
7. please this medicine is placed on the place that child can not contact.
8. as used other medicines, please Ref Dr or pharmacist before using this medicine.
The invention has the beneficial effects as follows: the present invention combines clinical practice for many years to develop on the basis of Traditional Chinese Medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.All medicines amount to the effect having liver and kidney tonifying, nourish heart, calm the nerves mutually, and treatment climacteric syndrome has the high and feature such as to have no side effect of determined curative effect, instant effect, cure rate.
Detailed description of the invention
The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.
Embodiment 1
Each crude drug is taken: Semen Cassiae 15 grams, Fructus Tritici Levis 20 grams, Herba Epimedii 12 grams, peninjau gardenia 12 grams, red Massa Medicata Fermentata 20 grams, Rhizoma Cyperi 12 grams, Fructus Akebiae 12 grams, Olibanum 12 grams, 10 grams, Semen Nelumbinis (coring), Semen Euryales (shelling) 20 grams, Ramulus Mori 15 grams, Herba Dendrobii 15 grams, Cortex Albiziae 15 grams, Caulis Polygoni Multiflori 30 grams, 9 grams, Radix Glycyrrhizae, 15 grams, Fructus Jujubae by following weight.By above-mentioned each taste crude drug pulverization, be prepared into capsule according to a conventional method.
Embodiment 2
Each crude drug is taken: Semen Cassiae 16 grams, Fructus Tritici Levis 21 grams, Herba Epimedii 13 grams, peninjau gardenia 13 grams, Massa Medicata Fermentata 21 grams, Rhizoma Cyperi 13 grams, Fructus Akebiae 13 grams, Olibanum 13 grams, 11 grams, Semen Nelumbinis (coring), Semen Euryales (shelling) 21 grams, Ramulus Mori 16 grams, Herba Dendrobii 16 grams, Cortex Albiziae 16 grams, Caulis Polygoni Multiflori 31 grams, 10 grams, Radix Glycyrrhizae, 16 grams, Fructus Jujubae by following weight.By above-mentioned each taste crude drug pulverization, be prepared into capsule according to a conventional method.
Embodiment 3
Each crude drug is taken: Semen Cassiae 14 grams, Fructus Tritici Levis 19 grams, Herba Epimedii 11 grams, peninjau gardenia 11 grams, Massa Medicata Fermentata 19 grams, Rhizoma Cyperi 11 grams, Fructus Akebiae 11 grams, Olibanum 11 grams, 9 grams, Semen Nelumbinis (coring), Semen Euryales (shelling) 19 grams, Ramulus Mori 14 grams, Herba Dendrobii 14 grams, Cortex Albiziae 14 grams, Caulis Polygoni Multiflori 29 grams, 8 grams, Radix Glycyrrhizae, 14 grams, Fructus Jujubae by following weight.By above-mentioned each taste crude drug pulverization, be prepared into capsule according to a conventional method.
Model case:
Case 1
Ma, female, 48 years old, people from Jieshou City, Anhui Province.Patient is self-induction dysphoria, yawn work, irritable feverish sensation of chest and heart frequently all day over 2 years, and hospital examines as climacteric syndrome.Integrative therapy, heavy time light during symptom, meet exacerbation of symptoms after direct stimulation, patient examines my institute in October, 2011, looks into, red tongue, few tongue, thready and rapid pulse, examine as dirty deficiency of YIN, blood deficiency can not be reposed, after giving 4 courses for the treatment of of Drug therapy of the present invention, symptom disappears completely, patient is rehabilitation, follows up a case by regular visits to 1 year without recurrence.
Case 2
Side so-and-so, female, 49 years old, Jieshou City, Anhui Province people from Dongcheng.Suffer from climacteric syndrome more than a year, in May, 2012 examines my institute, fully recovers, follow up a case by regular visits to 1 year without recurrence after giving three courses for the treatment of of Drug therapy of the present invention.
Case 3
Shen so-and-so, female, 53 years old, Anhui Province Fuyang City people.In June, 2011 goes to a doctor, 1 year irregular menstrual period of readme.The a burst of heating of conscious Head And Face, sweating, irritable, sometimes feverish sensation in the palms and soles.Have a medical check-up: red tongue white and thin fur, stringy and thready pulse.Examine as climacteric syndrome, belong to deficiency of both YIN and YANG.Give side's medicine of the present invention, take 4 courses for the treatment of, subjective symptoms obviously alleviates, and continues to take 4 courses for the treatment of, and all diseases disappear and fully recover.Follow up a case by regular visits to and do not recur again so far.
Case 4
Cai so-and-so, female, 51 years old, people from Ningguo City of Anhui Province.In April, 2011 goes to a doctor, and menstruation stops half a year, and the conscious whole body is uncomfortable, hectic fever, sweating, vexed insomnia, kind worry of thinking much.Examine as climacteric syndrome.Give Chinese medicine of the present invention and take 2 courses for the treatment of, the symptom such as hectic fever, sweating obviously alleviates, and continues to take 4 courses for the treatment of, transference cure, and recovery from illness, follows up a case by regular visits to and do not recur so far again.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
Claims (1)
1. the Chinese medicine for climacteric syndrome, it is characterized in that, be made up of the crude drug of following weight: Semen Cassiae 15 grams, Fructus Tritici Levis 20 grams, Herba Epimedii 12 grams, peninjau gardenia 12 grams, Massa Medicata Fermentata 20 grams, Rhizoma Cyperi 12 grams, Fructus Akebiae 12 grams, Olibanum 12 grams, 10 grams, Semen Nelumbinis, Semen Euryales 20 grams, Ramulus Mori 15 grams, Herba Dendrobii 15 grams, Cortex Albiziae 15 grams, Caulis Polygoni Multiflori 30 grams, 9 grams, Radix Glycyrrhizae, 15 grams, Fructus Jujubae; During preparation, take each taste crude drug by weight described in prescription, by above-mentioned each taste crude drug pulverization, incapsulate.
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| CN201310496727.9A CN103599406B (en) | 2013-10-21 | 2013-10-21 | A kind of Chinese medicine for climacteric syndrome |
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| CN201310496727.9A CN103599406B (en) | 2013-10-21 | 2013-10-21 | A kind of Chinese medicine for climacteric syndrome |
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| CN103599406B true CN103599406B (en) | 2015-09-02 |
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Non-Patent Citations (3)
| Title |
|---|
| 中医治疗女性更年期综合征的处方规律探讨;金香兰;《中国中医基础医学杂志》;20080430;第14卷(第4期);第292页右栏第4-7段，第293页左栏第1-4段和右栏第1段 * |
| 更年期综合征食疗方;叶水泉;《健康》;20020331;第24页第5段 * |
| 甘麦大枣汤治疗女性更年期潮热汗出;杨倜;《中国医学创新》;20121130;第9卷(第32期);第126页左栏第1.2节 * |
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Effective date of registration: 20200113 Address after: 210000 room 1204, building 2, 272 Jiqingmen street, Gulou District, Nanjing, Jiangsu Province Patentee after: Nanjing Zhongyi Pharmaceutical Co.,Ltd. Address before: 236500 Anhui city of Fuyang Province Jieshou City West Office Zhang Zhuang Road No. 72 Building 1 4 Patentee before: Zhang Xia |
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