CN101979059A - Medicinal preparation for treating acne and preparation method thereof - Google Patents
Medicinal preparation for treating acne and preparation method thereof Download PDFInfo
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- CN101979059A CN101979059A CN 201010520446 CN201010520446A CN101979059A CN 101979059 A CN101979059 A CN 101979059A CN 201010520446 CN201010520446 CN 201010520446 CN 201010520446 A CN201010520446 A CN 201010520446A CN 101979059 A CN101979059 A CN 101979059A
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Abstract
The invention publishes a medicinal preparation for treating acne and a preparation method thereof. The medicinal preparation is mainly prepared from weeping forsythiae capsule, honeysuckle flower, baical skullcap root, lightyellow sophora root, Chinese honeylocust spine, indigowoad root, Paris polyphylla, loquat leaf, Chinese angelica, root of red-rooted salvia, amur corktree bark, golden thread, wild chrysanthemum, dark plum fruit, mint, glutinous rice and bran coat. In the method, the conventional fermentation process method in which Chinese yeast, blocky yeast and yeast are added is adopted. Clinical verification shows that the preparation has unique therapeutic effect on the acne, does not have side effect, has wide medicinal resource, is easy to prepare, has definite therapeutic effect and is worthy of popularization.
Description
Technical field:
The present invention relates to a kind of Retinoids, Retin-A, Renova, Accutane preparation, the invention still further relates to the preparation method of this medicine, belong to Chinese medicine ferment making field.
Background technology:
Acne vulgaris (abbreviation acne) is a kind of pilosebaceous chronic inflammatory disease dermatosis that betides.Another name has: acne, whelk, comedo, skin sore etc.Be common in positions such as face, shirtfront, back and blackhead, hoary hair's acne, pustule, cyst, areolar tissue etc. occur.The traditional Chinese medical science is called the lung-wind syndrome whelk, thinks relevant with " hot, strongly fragrant, wet, the stasis of blood ".Western medicine thinks that the mechanism of primary disease includes following four morbidity links.1: androgen and sebaceous gland hyperfunctioning.2: infundibulum of hair follicle portion hyperkeratosis.3: action of microorganisms in the pilosebaceous unit.4: inflammation and host's immunoreation.Wherein active is that sebum secretion increases, and the growth of sebaceous gland and secretion are subjected to androgenic domination, androgen also can make pilosebaceous unit epithelium generation keratinization and make the channel narrows of draining sebum, too much sebum row is not gone out, savings is in the pilosebaceous unit system, original normal flora imbalance in the sebaceous gland at this moment, the enzyme that decomposes sebum can be bred and produce to the skin ulcer propionibacterium of fullying recover from an illness wherein in a large number.After sebum decomposed, the free fatty of generation stimulated also damage surrounding tissue, causes the inflammatory reaction based on sebaceous gland and follicular orifice, and this has just formed sebum and has increased, and----arranging fat-----bacterial infection that is obstructed is the acne pathogenesis in axle center.Certainly, also also have many other risk factors: also in action as Personal hygiene, skin type, living habit and overall health of patients.
Though the external medicine preparation kind of treatment acne is more at present, has many drawbacks, as weak curative effect, the relapse rate height; It is many that medicine is formed with Western medicine, and shortcoming is that zest is strong, and side effect is bigger, and the improper use meeting increases the weight of the state of an illness.
Summary of the invention:
Purpose of the present invention is exactly at the prior art deficiency, and the pharmaceutical preparation of a kind of easy to use, determined curative effect, treatment acne that toxic and side effects is little is provided for society.
Another object of the present invention just provides the preparation method of the pharmaceutical preparation of this treatment acne.
The solution of the object of the invention is at the theory of Chinese medicine about acne, based on motherland's medical science pathogenetic understanding of acne and Therapeutic Principle is filtered out tens of kinds of medicines, realizes with the following method.
Raw material in the pharmaceutical preparation of the present invention comes from natural plants: Oryza glutinosa, bran coat, Fructus Forsythiae, Flos Lonicerae, Radix Scutellariae, Radix Sophorae Flavescentis, Spina Gleditsiae, Radix Isatidis, Rhizoma Paridis, Folium Eriobotryae, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Cortex Phellodendri, Rhizoma Coptidis, Flos Chrysanthemi Indici, Fructus Mume, Herba Menthae, have no side effect at no hormone.The medicament composing prescription principle is:
Fructus Forsythiae: heat clearing away, detoxifcation, eliminating stagnation, detumescence;
Flos Lonicerae: heat-clearing and toxic substances removing, dispelling wind collateral dredging;
Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication is doublely gone into blood system, can removing heat from blood and stop blooding;
Radix Sophorae Flavescentis: heat clearing and damp drying, killing parasites for relieving itching;
Spina Gleditsiae: detumescence poison holding, evacuation of pus, parasite killing;
Radix Isatidis: heat clearing away, detoxifcation, removing heat from blood;
Rhizoma Paridis: heat-clearing and toxic substances removing, reducing swelling and alleviating pain;
Folium Eriobotryae: clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI;
Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, loosening bowel to relieve constipation;
Radix Salviae Miltiorrhizae: blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle;
Cortex Phellodendri: heat clearing and damp drying, eliminating fire and detoxication;
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication;
Flos Chrysanthemi Indici: heat-clearing and toxic substances removing;
Fructus Mume: astringe the lung, promote the production of body fluid;
Herba Menthae: saturating dermexanthesis poison.
All medicines cooperate, and respectively execute the chief, and synergism is evident in efficacy.By pharmaceutical properties, pharmacological action after the fermenting process of preparing a series of variations taking place, acts on excellent.
Each raw material consumption is respectively (by weight) among the present invention:
System liquor raw material (100 parts in Oryza glutinosa, 100 parts of bran coat, 200 parts in yeast for brewing rice wine, bent 300 parts of piece, 300 parts in yeast), 10 parts of Fructus Forsythiaes, 10 parts of Flos Lonicerae, 10 parts of Radix Scutellariaes, 10 parts of Radix Sophorae Flavescentiss, 10 parts of Spina Gleditsiaes, 10 parts of Radix Isatidis, 10 parts of Rhizoma Paridis, 10 parts of Folium Eriobotryaes, 30 parts of Radix Angelicae Sinensis, 30 parts of Radix Salviae Miltiorrhizaes, 10 parts of Cortex Phellodendris, 10 parts of Rhizoma Coptidis, 10 parts of Flos Chrysanthemi Indicis, 10 parts of Fructus Mumes, 10 parts of Herba Menthaes
The preparation method of pharmaceutical preparation of the present invention is as follows:
1: 10 parts the chopping back is standby respectively for 10 parts of Fructus Forsythiaes, 10 parts of Flos Lonicerae, 10 parts of Radix Scutellariaes, 10 parts of Radix Sophorae Flavescentiss, 10 parts of Spina Gleditsiaes, 10 parts of Radix Isatidis, 10 parts of Rhizoma Paridis, 10 parts of Folium Eriobotryaes, 30 parts of Radix Angelicae Sinensis, 30 parts of Radix Salviae Miltiorrhizaes, 10 parts of Cortex Phellodendris, 10 parts of Rhizoma Coptidis, 10 parts of Flos Chrysanthemi Indicis, 10 parts of Fructus Mumes, Herba Menthae.
2: get and pulverize 5 parts of Fructus Forsythiaes later, 5 parts of Flos Lonicerae, 5 parts of Radix Scutellariaes, 5 parts of Radix Sophorae Flavescentiss, 5 parts of Spina Gleditsiaes, 5 parts of Radix Isatidis, 5 parts of Rhizoma Paridis, 5 parts of Folium Eriobotryaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Salviae Miltiorrhizaes, 5 parts of Cortex Phellodendris, 5 parts of Rhizoma Coptidis, 5 parts of Flos Chrysanthemi Indicis, 5 parts of Fructus Mumes, after cooking, 5 parts of Herba Menthaes join system liquor raw material (100 parts in Oryza glutinosa, 100 parts of bran coat, 200 parts in yeast for brewing rice wine, bent 300 parts of piece, 300 parts in yeast) in, pour big wine jar after stirring into, smooth out with the fingers flat, dig a little pool in central authorities, putting the bamboo beach wormwood seals wine vat then, the temperature for the treatment of fermentation materials reaches 24-28 ℃, keeps 5 days.
After 3:5 days, the long-pending full fermented glutinous rice of bamboo beach wormwood in the intermediary little pool of wine vat, get and pulverize 5 parts of Fructus Forsythiaes later, 5 parts of Flos Lonicerae, 5 parts of Radix Scutellariaes, 5 parts of Radix Sophorae Flavescentiss, 5 parts of Spina Gleditsiaes, 5 parts of Radix Isatidis, 5 parts of Rhizoma Paridis, 5 parts of Folium Eriobotryaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Salviae Miltiorrhizaes, 5 parts of Cortex Phellodendris, 5 parts of Rhizoma Coptidis, 5 parts of Flos Chrysanthemi Indicis, 5 parts of Fructus Mumes, 5 parts of Herba Menthaes cook the back and add by step 2 and obtain fermenting in the material of back, and cold water poured in the cylinder for 2000 parts, flood material, after mixing evenly, the cylinder cap of filling a wine cup for again sternly continues fermentation, the temperature of fermentation materials can rise to 38-39 ℃, about the 5th day, temperature is reduced to 33-35 ℃, shows that alcohol fermentation finishes.
4: material after the fermentation that will obtain by step 3, take out and put into steaming kier and distill, the steam that comes out from steaming kier is through cooling, and the gained filling liquid is promptly.
Through clinical verification, show that this medicine has unique curative effect to acne, have no side effect, the medicine source is extensive, and preparation is simple, and determined curative effect is worthy to be popularized.
Specific embodiment 1:
(1) it is standby that Fructus Forsythiae 10kg, Flos Lonicerae 10kg, Radix Scutellariae 10kg, Radix Sophorae Flavescentis 10kg, Spina Gleditsiae 10kg, Radix Isatidis 10kg, Rhizoma Paridis 10kg, Folium Eriobotryae 10kg, Radix Angelicae Sinensis 30kg, Radix Salviae Miltiorrhizae 30kg, Cortex Phellodendri 10kg, Rhizoma Coptidis 10kg, Flos Chrysanthemi Indici 10kg, Fructus Mume 10kg, Herba Menthae 10kg shred the back respectively.
(2) get pulverizing Fructus Forsythiae 5kg later, Flos Lonicerae 5kg, Radix Scutellariae 5kg, Radix Sophorae Flavescentis 5kg, Spina Gleditsiae 5kg, Radix Isatidis 5kg, Rhizoma Paridis 5kg, Folium Eriobotryae 5kg, Radix Angelicae Sinensis 15kg, Radix Salviae Miltiorrhizae 15kg, Cortex Phellodendri 5kg, Rhizoma Coptidis 5kg, Flos Chrysanthemi Indici 5kg, Fructus Mume 5kg, after cooking, Herba Menthae 5kg joins system liquor raw material (Oryza glutinosa 100kg, bran coat 100kg, yeast for brewing rice wine 200kg, the bent 300kg of piece, yeast 300kg) in, pour big wine jar after stirring into, smooth out with the fingers flat, dig a little pool in central authorities, putting the bamboo beach wormwood seals wine vat then, the temperature for the treatment of fermentation materials reaches 24-28 ℃, keeps 5 days.
After (3) 5 days, the long-pending full fermented glutinous rice of bamboo beach wormwood in the intermediary little pool of wine vat, get and pulverize Fructus Forsythiae 5kg later, Flos Lonicerae 5kg, Radix Scutellariae 5kg, Radix Sophorae Flavescentis 5kg, Spina Gleditsiae 5kg, Radix Isatidis 5kg, Rhizoma Paridis 5kg, Folium Eriobotryae 5kg, Radix Angelicae Sinensis 15kg, Radix Salviae Miltiorrhizae 15kg, Cortex Phellodendri 5kg, Rhizoma Coptidis 5kg, Flos Chrysanthemi Indici 5kg, Fructus Mume 5kg, Herba Menthae 5kg cooks the back and adds by step 2 and obtain fermenting in the material of back, and cold water 2000kg poured in the cylinder, flood material, after mixing evenly, the cylinder cap of filling a wine cup for again sternly continues fermentation, the temperature of fermentation materials can rise to 38-39 ℃, about the 5th day, temperature is reduced to 33-35 ℃, shows that alcohol fermentation finishes.
(4) material after the fermentation that will be obtained by step (3) takes out and puts into steaming kier and distill, and the steam that comes out from steaming kier is through cooling, and the gained filling liquid promptly.
Specific embodiment 2: pharmaceutically active experiment
One, clinical data
Totally 88 routine out-patients are divided into treatment at random and organize 48 examples and matched group 40 examples.Treatment group: male 12 examples, women 36 examples; Minimum 15 years old of age, maximum 37 years old, average 24.5 years old; The course of disease 1 month-12 years, average 3.5 years.Matched group: male 11 examples, women 29 examples; Minimum 16 years old of age, maximum 39 years old, average 25.6 years old; The course of disease 1 month-11 years, average 3.4 years.Two groups of ages, sex, course of disease there was no significant difference (P＞0.05).
By acne skin lesion grading, adopt Pillsbury4 level staging.The I level: acne are main skin lesion, visible a small amount of pimple and abscess, and total skin lesion is less than 30.The II level: acne are arranged, and with moderate pimple and abscess, total skin lesion is between 31-50.The III level: acne are arranged, with a large amount of pimples and abscess, accidental big inflammatory damage, widely distributed, total skin lesion is counted between 51-100, and the tuberosity number is less than 3.The IV level: tuberosity, cyst type acne or aggretion type acne, total skin lesion number is more than 100, and tuberosity and cyst are more than 3.Treatment group: I level 12 examples, II level 16 examples, III level 17 examples, IV level 3 examples.Matched group: I level 9 examples, II level 13 examples, III level 15 examples, IV level 3 examples.Two groups of severity extent there was no significant differences (P＞0.05).
Two, Therapeutic Method
The treatment group: be applied to the affected part with gained medicinal liquid of the present invention, 3 times on the 1st, 7 days is a course of treatment, totally 4 courses of treatment.
Matched group: use commercially available Retinamido-ester dimension E emulsifiable paste (having another name called " the power acne king of nation " Chongqing Hua Bang pharmaceutical Co. Ltd produces) to be applied to the affected part, 2 times on the 1st, 7 days is a course of treatment, totally 4 courses of treatment.
Three, criterion of therapeutical effect
By the level Four standard.Be almost recovered: the skin lesion sum reduces more than 90%; Produce effects: the skin lesion sum reduces 60%-89%; Effectively: the skin lesion sum reduces 30%-59%; Invalid: the skin lesion sum reduces＜30%.
Four, therapeutic outcome
Treatment group and matched group ordinary circumstance do not have significant difference, meet comparability.Two groups of therapeutic outcomes see Table 1.Do not have obvious adverse reaction in the treatment group treatment, matched group has 8 examples xerosis cutis, decortication phenomenon to occur and drug withdrawal.Being almost recovered adds produce effects and adds and effectively be effective percentage, and two groups total effective rate is respectively 91.67% and 65.00%.Learn by statistics to handle significant difference (P＜0.01) is arranged.
Table 1 liang group curative effect comparative example (%)
| Group | The example number | Be almost recovered | Produce effects | Effectively | Invalid | Total effective rate |
| The treatment group | 48 | 20(41.67％) | 13(27.08％) | 11(22.92％) | 4(8.33％) | 91.67％△ |
| Matched group | 40 | 6(15.00％) | 10(25％.00) | 10(25.00％) | 14(15.00％) | 65.00％ |
Annotate: compare △ x^2=12.91, P＜0.01 with matched group
Claims (2)
1. pharmaceutical preparation for the treatment of acne.It is characterized in that containing following composition and consumption thereof (by weight):
System liquor raw material (100 parts in Oryza glutinosa, 100 parts of bran coat, 200 parts in yeast for brewing rice wine, bent 300 parts of piece, 300 parts in yeast), 10 parts of Fructus Forsythiaes, 10 parts of Flos Lonicerae, 10 parts of Radix Scutellariaes, 10 parts of Radix Sophorae Flavescentiss, 10 parts of Fructus Gleditsia, 10 parts of Radix Isatidis, 10 parts of Rhizoma Paridis, 10 parts of Folium Eriobotryaes, 30 parts of Radix Angelicae Sinensis, 30 parts of Radix Salviae Miltiorrhizaes, 10 parts of Cortex Phellodendris, 10 parts of Rhizoma Coptidis, 10 parts of Flos Chrysanthemi Indicis, 10 parts of Fructus Mumes, 10 parts of Herba Menthaes.
2. preparation method for the treatment of the pharmaceutical preparation of acne.It is characterized in that:
A: 10 parts the chopping back is standby respectively for 10 parts of Fructus Forsythiaes, 10 parts of Flos Lonicerae, 10 parts of Radix Scutellariaes, 10 parts of Radix Sophorae Flavescentiss, 10 parts of Fructus Gleditsia, 10 parts of Radix Isatidis, 10 parts of Rhizoma Paridis, 10 parts of Folium Eriobotryaes, 30 parts of Radix Angelicae Sinensis, 30 parts of Radix Salviae Miltiorrhizaes, 10 parts of Cortex Phellodendris, 10 parts of Rhizoma Coptidis, 10 parts of Flos Chrysanthemi Indicis, 10 parts of Fructus Mumes, Herba Menthae.
B: get and pulverize 5 parts of Fructus Forsythiaes later, 5 parts of Flos Lonicerae, 5 parts of Radix Scutellariaes, 5 parts of Radix Sophorae Flavescentiss, 5 parts of Fructus Gleditsia, 5 parts of Radix Isatidis, 5 parts of Rhizoma Paridis, 5 parts of Folium Eriobotryaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Salviae Miltiorrhizaes, 5 parts of Cortex Phellodendris, 5 parts of Rhizoma Coptidis, 5 parts of Flos Chrysanthemi Indicis, 5 parts of Fructus Mumes, after cooking, 5 parts of Herba Menthaes join (100 parts in Oryza glutinosa in 1000 parts of system liquor raw materials, 100 parts of bran coat, 200 parts in yeast for brewing rice wine, bent 300 parts of piece, 300 parts in yeast), pour big wine jar after stirring into, smooth out with the fingers flat, dig a little pool in central authorities, putting the bamboo beach wormwood seals wine vat then, the temperature for the treatment of fermentation materials reaches 24-28 ℃, keeps 5 days.
After C:5 days, the long-pending full fermented glutinous rice of bamboo beach wormwood in the intermediary little pool of wine vat, get and pulverize 5 parts of Fructus Forsythiaes later, 5 parts of Flos Lonicerae, 5 parts of Radix Scutellariaes, 5 parts of Radix Sophorae Flavescentiss, 5 parts of Fructus Gleditsia, 5 parts of Radix Isatidis, 5 parts of Rhizoma Paridis, 5 parts of Folium Eriobotryaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Salviae Miltiorrhizaes, 5 parts of Cortex Phellodendris, 5 parts of Rhizoma Coptidis, 5 parts of Flos Chrysanthemi Indicis, 5 parts of Fructus Mumes, 5 parts of Herba Menthaes cook the back and add by step B and obtain fermenting in the material of back, and cold water poured in the cylinder for 2000 parts, flood material, after mixing evenly, the cylinder cap of filling a wine cup for again sternly continues fermentation, the temperature of fermentation materials can rise to 38-39 ℃, about the 5th day, temperature is reduced to 33-35 ℃, shows that alcohol fermentation finishes.
D: material after the fermentation that will obtain by step C, take out and put into steaming kier and distill, the steam that comes out from steaming kier is through cooling, and the gained filling liquid is promptly.
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| CN 201010520446 CN101979059A (en) | 2010-10-26 | 2010-10-26 | Medicinal preparation for treating acne and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670926A (en) * | 2012-03-19 | 2012-09-19 | 苏甲臣 | Medicine for treating acne |
| CN102895471A (en) * | 2012-09-24 | 2013-01-30 | 赵美兴 | Medicine for treatment of acne, folliculitis and pustular herpes and preparation method thereof |
| CN104547734A (en) * | 2014-12-04 | 2015-04-29 | 万文静 | Preparation process and method of traditional Chinese medicinal composition for treating acnes and spots |
| CN104547127A (en) * | 2015-02-04 | 2015-04-29 | 郑华娟 | Acne-removing preparation |
| CN105168079A (en) * | 2015-08-26 | 2015-12-23 | 王晶 | Traditional Chinese medicine skin-care product treating closed acne |
| CN111700842A (en) * | 2020-07-08 | 2020-09-25 | 黄艳 | Mask composition, preparation method and use method thereof and mask |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101357176A (en) * | 2008-09-16 | 2009-02-04 | 杨运金 | Acne, sore specific effect traditional Chinese medicine preparation and preparation method thereof |
| CN101637578A (en) * | 2009-07-07 | 2010-02-03 | 朱建华 | Medicinal preparation for treating acnes, whelks and folliculitis and preparation method thereof |
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2010
- 2010-10-26 CN CN 201010520446 patent/CN101979059A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101357176A (en) * | 2008-09-16 | 2009-02-04 | 杨运金 | Acne, sore specific effect traditional Chinese medicine preparation and preparation method thereof |
| CN101637578A (en) * | 2009-07-07 | 2010-02-03 | 朱建华 | Medicinal preparation for treating acnes, whelks and folliculitis and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670926A (en) * | 2012-03-19 | 2012-09-19 | 苏甲臣 | Medicine for treating acne |
| CN102895471A (en) * | 2012-09-24 | 2013-01-30 | 赵美兴 | Medicine for treatment of acne, folliculitis and pustular herpes and preparation method thereof |
| CN104547734A (en) * | 2014-12-04 | 2015-04-29 | 万文静 | Preparation process and method of traditional Chinese medicinal composition for treating acnes and spots |
| CN104547127A (en) * | 2015-02-04 | 2015-04-29 | 郑华娟 | Acne-removing preparation |
| CN105168079A (en) * | 2015-08-26 | 2015-12-23 | 王晶 | Traditional Chinese medicine skin-care product treating closed acne |
| CN111700842A (en) * | 2020-07-08 | 2020-09-25 | 黄艳 | Mask composition, preparation method and use method thereof and mask |
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Open date: 20110223 |