CN105194264A - Traditional Chinese medicinal electuary for treating constipation, and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicinal electuary for treating constipation, and a preparation method thereof. Raw medicines for preparing the electuary comprise, by weight, 25-35 parts of Caulerpa lentillifera, 8-10 parts of Folium Sennae, 10-15 parts of aloe, 9-12 parts of honey-fried licorice root, 5-9 parts of black sesame, 6-8 parts of Semen Calonyctionis Muricati, 6-9 parts of Chinese angelica, 5-8 parts of cassia seed, 6-9 parts of Poria cocos, 5-8 parts of Radix Asparagi, 9-12 parts of fig, 20-25 parts of purple sweet potato, 8-10 parts of onion and 8-12 parts of Pleurotus ostreatus. The electuary can rapidly clear intestine and relax bowel, has a blood purifying effect, and has very good prevention and treatment effects on systematic poisoning caused by constipation.

Description

A kind of instant particles as Chinese medicine for the treatment of constipation and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, particularly a kind of instant particles as Chinese medicine for the treatment of constipation and preparation method thereof.

Background technology

Constipation is that a kind of constipation is obstructed, and defecation time extends or the involved and abstruse not smooth disease for stool, can accompany and sees abdominal distention, stomachache, stool band blood, proctoptosis, anal fissure or bring out hemorrhoid etc.Along with rhythm of life accelerate, dietary structure changes, the aging of social population and the impact of psychiatric and social factor, constipation has become one of common disease having a strong impact on modern's quality of life, and prevalence is in ascendant trend year by year.The prevalence of constipation in crowd up to 27%, but only has sub-fraction constipation person to go to a doctor.Constipation can affect the people of each age group.Women is more than male, old more than blue or green, the prime of life.Because constipation sickness rate is high, the cause of disease is complicated, patient often has manifold vexations, and can affect quality of life when constipation is serious.Constipation often shows as: awareness of defecation is few, just secondary also few; Defecation is difficult, effort; Defecation is not smooth; Constipation with dry stool, hard just, defecation is not felt only; Constipation is with stomachache or abdominal discomfort.Some patients is also with Behavioral disturbances such as insomnia, agitation, dreaminess, depression, anxieties.Because constipation is a kind of comparatively general symptom, symptoms of varying severity, most people usually do not go specially to comprehend, and think that constipation is not disease, need not treat, but the harm of in fact constipation are very large.Feces was detained for a long time in intestinal, and putrefactive fermentation, produces many toxic gas and noxious substance, and these toxin, poison are absorbed by the body with the Reabsorption of rectum and enter blood, again along with blood circulation distribution whole body, caused systemic toxicity.Prolonged constipation, vitality declines because of chronic poisoning, causes weakness, easily disease, senilism and has the allotted portion of life reduced by having or getting more than one deserves.The medicine of existing treatment constipation, is main mainly with stimulation intestinal defecation, mostly there is side effect larger, stomachache, intestinal is easily caused to dewater, and easily produce the problem of drug dependence, and the toxin being absorbed into blood can not be removed fast and effectively, unavoidably these toxin are to the injury of health.

Summary of the invention

The object of the invention is to make up prior art deficiency, there is provided a kind of instant particles as Chinese medicine for the treatment of constipation and preparation method thereof, this electuary while quick loosening bowel to relieve constipation, can play the effect purified the blood, to treatment constipation, and the systemic toxicity that prophylactic treatment is caused by constipation has good curative effect.

To achieve these goals, technical scheme provided by the invention is as follows:

Treat an instant particles as Chinese medicine for constipation, crude drug composition and the parts by weight thereof of making described electuary comprise: long shoot Fructus Vitis viniferae Caulerpa 25-35 part, Folium Sennae 8-10 part, Aloe 10-15 part, Radix Glycyrrhizae Preparata 9-12 part, Semen Sesami Nigrum 5-9 part, Herba Solani Surattensis 6-8 part, Radix Angelicae Sinensis 6-9 part, Semen Cassiae 5-8 part, Poria 6-9 part, Radix Asparagi 5-8 part, Fructus Fici 9-12 part, Rhizoma Steudnerae Henryanae 20-25 part, Bulbus Allii Cepae 8-10 part, Pleurotus ostreatus 8-12 part.

Further, crude drug composition and the parts by weight thereof of making described electuary comprise: long shoot Fructus Vitis viniferae Caulerpa 25 parts, Folium Sennae 8 parts, Aloe 10 parts, Radix Glycyrrhizae Preparata 9 parts, Semen Sesami Nigrum 5 parts, Herba Solani Surattensis 6 parts, Radix Angelicae Sinensis 6 parts, Semen Cassiae 5 parts, 6 parts, Poria, Radix Asparagi 5 parts, Fructus Fici 9 parts, Rhizoma Steudnerae Henryanae 20 parts, Bulbus Allii Cepae 8 parts, Pleurotus ostreatus 8 parts.

Further, crude drug composition and the parts by weight thereof of making described electuary comprise: long shoot Fructus Vitis viniferae Caulerpa 30 parts, Folium Sennae 9 parts, Aloe 12 parts, Radix Glycyrrhizae Preparata 11 parts, Semen Sesami Nigrum 7 parts, Herba Solani Surattensis 7 parts, Radix Angelicae Sinensis 7 parts, Semen Cassiae 6 parts, 8 parts, Poria, Radix Asparagi 7 parts, Fructus Fici 11 parts, Rhizoma Steudnerae Henryanae 22 parts, Bulbus Allii Cepae 9 parts, Pleurotus ostreatus 10 parts.

Further, crude drug composition and the parts by weight thereof of making described electuary comprise: long shoot Fructus Vitis viniferae Caulerpa 35 parts, Folium Sennae 10 parts, Aloe 15 parts, Radix Glycyrrhizae Preparata 12 parts, Semen Sesami Nigrum 9 parts, Herba Solani Surattensis 8 parts, Radix Angelicae Sinensis 9 parts, Semen Cassiae 8 parts, 9 parts, Poria, Radix Asparagi 8 parts, Fructus Fici 12 parts, Rhizoma Steudnerae Henryanae 25 parts, Bulbus Allii Cepae 10 parts, Pleurotus ostreatus 12 parts.

The invention also discloses the preparation method of the instant particles as Chinese medicine of described treatment constipation, comprise the following steps:

(1) Rhizoma Steudnerae Henryanae is cleaned the cube fritter that peeling is cut into length of side 2cm and is cooked at 100 DEG C of steaming and decocting 20min, long shoot Fructus Vitis viniferae Caulerpa, Semen Sesami Nigrum, Pleurotus ostreatus are cleaned, fritter is cut in Bulbus Allii Cepae peeling, and the ripe Rhizoma Steudnerae Henryanae handled well, long shoot Fructus Vitis viniferae Caulerpa, Semen Sesami Nigrum, Bulbus Allii Cepae, Pleurotus ostreatus are ground into 200 order mixed-powders after being mixed together lyophilization;

(2) Folium Sennae, Aloe, Radix Glycyrrhizae Preparata, Herba Solani Surattensis, Radix Angelicae Sinensis, Semen Cassiae, Poria, Radix Asparagi, Fructus Fici add the distilled water of its gross mass 4 times, soak 1 hour, slow fire boiling 1 hour, cross 500 order filter screen filtration after decocting, gained filter vacuum is concentrated into the thick paste that relative density is 1.30 ± 0.02 (60 DEG C);

(3) mixed-powder obtained in step (1) is added in thick paste obtained in step (2), mixing, granulate, dry, the instant particles as Chinese medicine of constipation must be treated.

The present invention, in order to treat constipation, effectively removes the blood poison that constipation causes, the method adopt loosening bowel to relieve constipation, purifying the blood simultaneously, while constipation relieving symptom, effectively removes blood poison, avoids the blood poison caused by constipation to damage body.According to Chinese medical theory determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, screen raw material of Chinese medicine by great many of experiments, refining agent method, make each efficacy of drugs produce synergism, thus reach the effect for the treatment of both the principal and secondary aspects of a disease.In the crude drug chosen:

Long shoot Fructus Vitis viniferae Caulerpa: have and purify the blood, blood pressure lowering, antioxidation, anticancer, antitumor action, long shoot Fructus Vitis viniferae Caulerpa rich in nutritive value, great benefit is had to be also referred to as " long-lived algae " in locality to health, it contains natural vitamin A, B group (B1, B2, B6, and the B12 that needs most of vegetarian), C, D, E and ferrum, zinc, magnesium, the mineral such as calcium, phylloxanthin (lutein), chlorophyll, protein, nucleic acid DNA, RNA and rare planting property polysaccharide body and 17 seed amino acids and multiple unsaturated fatty acid, the nutritional labeling of its preciousness and the alkaline speciality of natural high-quality, the long-term edible body constitution that can adjust becomes the healthy system of alkalescence, alkalescence system is just away from the key factor of cancer, vitamin A energy the liver protecting, stop and suppress the hypertrophy of cancerous cell in liver.It can make normal structure restore funcitons, vitamin E can play the effect stoping hepatic tissue aging, vitamin E can play the effect stoping hepatic tissue aging, and long shoot Fructus Vitis viniferae Caulerpa is nutritious, shows through nutrition determination and analysis, it contains a large amount of aminoacid, unsaturated fatty acid, polysaccharides, mineral, vitamin, is also rich in phosphorus, calcium, magnesium, copper, selenium and other trace elements.According to Japanese MEXT (2005) food standard ingredient standard, every 100 grams of long shoot Fructus Vitis viniferae Caulerpa, dietary fiber accounts for dry weight 24% ~ 26%, and protein accounts for dry weight 16%, and fat content accounts for dry weight 3%, not containing cholesterol;

Folium Sennae: the row that purges heat is stagnant, relieving constipation, diuretic.Stagnate for accumulation of heat, constipation is suffered from abdominal pain, edema distension.Cold in nature, containing anthraquinone derivative in Folium Sennae, its discharge function and zest other cathartics comparatively containing Anthraquinones are stronger, can with stomachache time under thus rushing down.

Aloe: property bitter cold, returns liver, large intestine channel, rushes down lower liver heat removing, parasite killing, is used for the treatment of constipation with heat retention, liver-fire headache, conjunctival congestion infantile convulsion, abdominal pain due to worm stagnation, scabies, hemorrhoid complicated by anal fistula; Aloe contains 75 kinds of elements, almost fit like a glove with human body cell desired substance, there is obvious health value, 1-Hydroxy-1,2,3-propanetricarboxylic acid. calcium etc. in Aloe has the effect of heart tonifying, blood circulation promoting, softening pipe-stem arteries, reduction cholesterol level, expansion blood capillary, make blood circulation unimpeded, reduce cholesterol value, alleviate heart burden, make blood pressure keep normal, remove the harmful substance in blood;

Radix Glycyrrhizae Preparata: the sweet temperature of property, returns spleen, stomach, lung meridian, has QI invigorating tonify deficiency, preventing phlegm from forming and stopping coughing, relieving spasm to stop pain, and the raw sun of tonifying YIN, in the high violent prescription of the property of medicine, can relax strong or alleviate toxic and side effects, again can the spleen and stomach regulating.As adjust stomach CHENGQI TANG with Radix Glycyrrhizae to relax slightly, Huang Zhixing, make to rush down lower unlikely too violent, and avoid it stimulate large intestine and produce stomachache;

Semen Sesami Nigrum: invigorating the liver and kidney, benefiting essence-blood, intestine moistening is dry.For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation;

Herba Solani Surattensis: bitter, cold, under rushing down, antidote against snake bite, main constipation, venom, Herba Solani Surattensis contains anthocyanidin, and anthocyanidin is the material of Polyphenols, has very good effect, and be easily absorbed by the blood for health care blood;

Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores;

Semen Cassiae: cold in nature, has liver heat removing and eyesight improving, loosening bowel to relieve constipation, the function of lowering blood-fat and reducing weight, can suppress the synthesis of total body fat, also has well decompose effect to the unnecessary fat in body;

Poria: sweet in the mouth, light, property is put down, promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming, for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia, promotes that toxin is discharged with urine, Poria can simultaneously strengthening the spleen and stomach hepatoprotective, evade the cold of Semen Cassiae, neither affect diet and healthy, also can reach the object of weight reducing;

Radix Asparagi: cold in nature, sweet in the mouth, hardship, YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, quench one's thirst for dryness of the lung dry cough, cough due to consumptive disease, thirsty, the vexed insomnia of Tianjin wound, interior-heat, dryness of the intestine constipation, diphtheria;

Fructus Fici: sweet, flat, nourishing the lung to arrest cough, clearing away heat and moistening the bowels.For cough with asthma, laryngopharynx swelling and pain, constipation, hemorrhoid;

Rhizoma Steudnerae Henryanae: its rich in proteins, starch, pectin, cellulose, aminoacid, vitamin and several mineral materials, also be rich in selenium element and anthocyanidin simultaneously, the special health care of the nutritious tool of Rhizoma Steudnerae Henryanae, gal4 amino acid is wherein all very easily by human consumption and absorption, the vitamin A be wherein rich in can improve the mucomembranous epithelial cell of vision and skin, vitamin C can make collagen protein normally synthesize, prevent and treat scorbutic generation, anthocyanidin is natural potent free radical scavenger, anthocyanidin is the material of Polyphenols, very good effect is had for health care blood, and be easily absorbed by the blood,

Bulbus Allii Cepae: the nutritional labeling in Bulbus Allii Cepae is very abundant, is not only rich in potassium, vitamin C, folic acid, zinc, selenium, and the nutrient such as cellulosic, and Bulbus Allii Cepae is the vegetable of known only prostaglandin-containing A.Prostaglandin A energy blood vessel dilating, reduction blood viscosity; thus can produce blood pressure lowering, increase blood flow coronarius; the effect of antithrombotic; the Quercetin of rich content in Bulbus Allii Cepae; the availability of its biology is very high; scientist's research report is pointed out; Quercetin may contribute to the oxidation preventing low density lipoprotein, LDL (LDL); for atherosclerosis; important protective effect can be provided; Bulbus Allii Cepae contains Herba Alii fistulosi allicin, has strong fragrance, adds and often draws tears from sb because abnormal smells from the patient is pungent man-hour.This special odor can gastric acid secretion just, appetite stimulator, and zoopery also proves, Bulbus Allii Cepae can improve gastrointestinal tract tension force, promote gastrointestinal peristalsis, thus play appetizing effect, have positive effect to the inappetence that atrophic gastritis, gastric dynamic dysfunction, dyspepsia etc. cause;

Pleurotus ostreatus: nature and flavor are sweet, temperature, there is wind-evil dispelling and cold-evil expelling, effect of relaxing muscles and tendons and activating QI and blood in the collateral, lumbago and skelalgia is controlled with dry, numb hand and foot, the diseases such as grain is obstructed, proteoglycan body in Pleurotus ostreatus has very strong inhibitory action to cancerous cell, energy enhancing body Immunologic function, normal food Pleurotus ostreatus, the metabolism improving human body can not only be played, the effect of regulating plant nerve, and to minimizing human serum cholesterol, reduce blood pressure and prevent and treat hepatitis, gastric ulcer, duodenal ulcer, hypertension etc. have obvious effect, Pleurotus ostreatus is rich in the mushroom of selenium, can blood pressure lowering, cholesterol reducing, prevent sclerosis of blood vessels, improve body's immunity, increase the level of immunoglobulin in body, excited hemopoietic function of bone marrow, and have laxation, clean blood, removing toxic substances, increase the effects such as intelligence, enlivened Digestion simultaneously, the not digested thing stayed of successful decomposition, so just contribute to the removing of intestinal, simultaneously, also has the effect promoting zymigen, the effect of toxin expelling or transport material.

In all medicines, long shoot Fructus Vitis viniferae Caulerpa and Aloe are monarch drug, the effect play loosening bowel to relieve constipation altogether, purifying the blood, and at discharge stool, while constipation relieving symptom, effectively remove blood poison, prevent and treat the systemic toxicity profiles caused by constipation.Folium Sennae, Semen Sesami Nigrum, Herba Solani Surattensis, Radix Angelicae Sinensis, Semen Cassiae, Poria, Radix Asparagi, Fructus Fici, Rhizoma Steudnerae Henryanae, Bulbus Allii Cepae, Pleurotus ostreatus are auxiliary, wherein, Semen Sesami Nigrum, Herba Solani Surattensis, Radix Angelicae Sinensis, Semen Cassiae, Poria, Radix Asparagi, Fructus Fici, Rhizoma Steudnerae Henryanae, Folium Sennae, Bulbus Allii Cepae, Pleurotus ostreatus can the effect of gain monarch drug loosening bowel to relieve constipation, make patient can discharge stool fast, reduction of patient is painful, Poria can simultaneously strengthening the spleen and stomach hepatoprotective, evades the cold of Semen Cassiae; Herba Solani Surattensis, Poria, Rhizoma Steudnerae Henryanae, Folium Sennae, Bulbus Allii Cepae, Pleurotus ostreatus can promote that monarch drug purifies the blood the effect of toxin, avoid the blood poison caused by constipation to affect other organs healthy, cause systemic toxicity profiles, wherein, Poria and Folium Sennae play diuresis, can promote that blood poison is discharged from urine.Radix Glycyrrhizae Preparata makes for assistant altogether, plays harmonizing yingfen and weifen, the effect of warming spleen and stomach for dispelling cold, can relax strong again can the spleen and stomach regulating, the property of Folium Sennae can be relaxed, make to rush down lower unlikely too suddenly, and avoid its stimulation large intestine and produce stomachache.Electuary of the present invention is pure Chinese medicinal preparation, selected medical material compatibility is suitable, formula is safe and effective, and adopt modern advanced medical pharmaceutical technology to make, there is treating both the principal and secondary aspects of a disease rapid-action, can effectively reduction of patient be painful, remove blood poison, the remarkable advantage of safe without toxic side effect, is adapted to the treatment to constipation symptom.

Beneficial effect of the present invention is: the present invention compensate for prior art deficiency, provide a kind of instant particles as Chinese medicine for the treatment of constipation and preparation method thereof, this electuary can while quick loosening bowel to relieve constipation, play the effect purified the blood, to treatment constipation, and the systemic toxicity that prophylactic treatment is caused by constipation has good curative effect.Specifically:

(1) instant particles as Chinese medicine of the present invention with long shoot Fructus Vitis viniferae Caulerpa and Aloe for monarch drug, long shoot Fructus Vitis viniferae Caulerpa is the nutraceutical introduced from Japan, at present can artificial cultivation in Qingdao, long shoot Fructus Vitis viniferae Caulerpa has and purifies the blood, blood pressure lowering, antioxidation, anticancer, antitumor action, long shoot Fructus Vitis viniferae Caulerpa rich in nutritive value, great benefit is had to be also referred to as " long-lived algae " in locality to health, it contains natural vitamin A, B group (B1, B2, B6, and the B12 that needs most of vegetarian), C, D, E and ferrum, zinc, magnesium, the mineral such as calcium, phylloxanthin (lutein), chlorophyll, protein, nucleic acid DNA, RNA and rare planting property polysaccharide body and 17 seed amino acids and multiple unsaturated fatty acid, the nutritional labeling of its preciousness and the alkaline speciality of natural high-quality, the long-term edible body constitution that can adjust becomes the healthy system of alkalescence, alkalescence system is just away from the key factor of cancer, vitamin A energy the liver protecting, stop and suppress the hypertrophy of cancerous cell in liver.It can make normal structure restore funcitons, vitamin E can play the effect stoping hepatic tissue aging, long shoot Fructus Vitis viniferae Caulerpa is nutritious, show through nutrition determination and analysis, it contains a large amount of aminoacid, unsaturated fatty acid, polysaccharides, mineral, vitamin, is also rich in phosphorus, calcium, magnesium, copper, selenium and other trace elements.According to Japanese MEXT (2005) food standard ingredient standard, every 100 grams of long shoot Fructus Vitis viniferae Caulerpa, dietary fiber accounts for dry weight 24% to 26%, protein accounts for dry weight 16%, fat content accounts for dry weight 3%, this algae is nutritious, be rich in dietary fiber, there is toxin expelling, the effect of cleaning the intestines and stomach, effectively can treat constipation, and can purify the blood, removing blood poison, Aloe rushes down lower liver heat removing, contain 75 kinds of elements, almost fit like a glove with human body cell desired substance, there is obvious health value, 1-Hydroxy-1,2,3-propanetricarboxylic acid. calcium etc. in Aloe has heart tonifying, blood circulation promoting, softening pipe-stem arteries, reduce cholesterol level, the effect of expansion blood capillary, make blood circulation unimpeded, reduce cholesterol value, alleviate heart burden, blood pressure is made to keep normal, remove the harmful substance in blood, Aloe and long shoot Fructus Vitis viniferae Caulerpa share, loosening bowel to relieve constipation can be played altogether, the effect purified the blood, at discharge stool, while constipation relieving symptom, effective removing blood poison, prevent and treat the systemic toxicity profiles caused by constipation.

(2) this instant particles as Chinese medicine compatibility is proper, the medical material such as Semen Cassiae, Poria is aided with Aloe, long shoot Fructus Vitis viniferae Caulerpa, can its effect Semen Sesami Nigrum of actual gain, Herba Solani Surattensis, Radix Angelicae Sinensis, Semen Cassiae, Poria, Radix Asparagi, Fructus Fici, Rhizoma Steudnerae Henryanae, Folium Sennae, Bulbus Allii Cepae, Pleurotus ostreatus can the effect of gain monarch drug loosening bowel to relieve constipation, make patient can discharge stool fast, reduction of patient is painful, Poria can simultaneously strengthening the spleen and stomach hepatoprotective, evades the cold of Semen Cassiae; Herba Solani Surattensis, Poria, Rhizoma Steudnerae Henryanae, Folium Sennae, Bulbus Allii Cepae, Pleurotus ostreatus can promote that monarch drug purifies the blood the effect of toxin, avoid the blood poison caused by constipation to affect other organs healthy, cause systemic toxicity profiles, wherein, Poria and Folium Sennae play diuresis, can promote that blood poison is discharged from urine.Meanwhile, be that assistant makes with Radix Glycyrrhizae Preparata, play harmonizing yingfen and weifen, the effect of warming spleen and stomach for dispelling cold, can relax strong again can the spleen and stomach regulating, the property of Folium Sennae can be relaxed, make to rush down lower unlikely too violent, and avoid its stimulation large intestine and produce stomachache, avoid the misery of therapeutic process increase patient.

Detailed description of the invention

According to following embodiment, the present invention may be better understood.But those skilled in the art will readily understand, concrete material proportion, process conditions and result thereof described by embodiment only should can not limit the present invention described in detail in claims yet for illustration of the present invention.

Embodiment 1

Treat an instant particles as Chinese medicine for constipation, crude drug composition and the parts by weight thereof of making described electuary comprise: long shoot Fructus Vitis viniferae Caulerpa 25 parts, Folium Sennae 8 parts, Aloe 10 parts, Radix Glycyrrhizae Preparata 9 parts, Semen Sesami Nigrum 5 parts, Herba Solani Surattensis 6 parts, Radix Angelicae Sinensis 6 parts, Semen Cassiae 5 parts, 6 parts, Poria, Radix Asparagi 5 parts, Fructus Fici 9 parts, Rhizoma Steudnerae Henryanae 20 parts, Bulbus Allii Cepae 8 parts, Pleurotus ostreatus 8 parts.

The preparation method of the instant particles as Chinese medicine of described treatment constipation, comprises the following steps:

(1) Rhizoma Steudnerae Henryanae is cleaned the cube fritter that peeling is cut into length of side 2cm and is cooked at 100 DEG C of steaming and decocting 20min, long shoot Fructus Vitis viniferae Caulerpa, Semen Sesami Nigrum, Pleurotus ostreatus are cleaned, fritter is cut in Bulbus Allii Cepae peeling, and the ripe Rhizoma Steudnerae Henryanae handled well, long shoot Fructus Vitis viniferae Caulerpa, Semen Sesami Nigrum, Bulbus Allii Cepae, Pleurotus ostreatus are ground into 500 order mixed-powders after being mixed together lyophilization;

(2) Folium Sennae, Aloe, Radix Glycyrrhizae Preparata, Herba Solani Surattensis, Radix Angelicae Sinensis, Semen Cassiae, Poria, Radix Asparagi, Fructus Fici add the distilled water of its gross mass 4 times, soak 1 hour, slow fire boiling 1 hour, cross 500 order filter screen filtration after decocting, gained filter vacuum is concentrated into the thick paste that relative density is 1.30 ± 0.02 (60 DEG C);

(3) mixed-powder obtained in step (1) is added in thick paste obtained in step (2), mixing, granulate, dry, the instant particles as Chinese medicine of constipation must be treated.

Usage and dosage: warm water is taken after mixing it with water, 3 times on the one, a 10g.

Embodiment 2

Treat an instant particles as Chinese medicine for constipation, crude drug composition and the parts by weight thereof of making described electuary comprise: long shoot Fructus Vitis viniferae Caulerpa 30 parts, Folium Sennae 9 parts, Aloe 12 parts, Radix Glycyrrhizae Preparata 11 parts, Semen Sesami Nigrum 7 parts, Herba Solani Surattensis 7 parts, Radix Angelicae Sinensis 7 parts, Semen Cassiae 6 parts, 8 parts, Poria, Radix Asparagi 7 parts, Fructus Fici 11 parts, Rhizoma Steudnerae Henryanae 22 parts, Bulbus Allii Cepae 9 parts, Pleurotus ostreatus 10 parts.

The preparation method of the instant particles as Chinese medicine of embodiment 2 is identical with embodiment 1 with usage and dosage.

Embodiment 3

Treat an instant particles as Chinese medicine for constipation, it is characterized in that, crude drug composition and the parts by weight thereof of making described electuary comprise: long shoot Fructus Vitis viniferae Caulerpa 35 parts, Folium Sennae 10 parts, Aloe 15 parts, Radix Glycyrrhizae Preparata 12 parts, Semen Sesami Nigrum 9 parts, Herba Solani Surattensis 8 parts, Radix Angelicae Sinensis 9 parts, Semen Cassiae 8 parts, 9 parts, Poria, Radix Asparagi 8 parts, Fructus Fici 12 parts, Rhizoma Steudnerae Henryanae 25 parts, Bulbus Allii Cepae 10 parts, Pleurotus ostreatus 12 parts.

The preparation method of the instant particles as Chinese medicine of embodiment 3 is identical with embodiment 1 with usage and dosage.

Embodiment 4 toxicity test

NIH mice 40, SPF level, body weight 20 ~ 25g, carries out acute toxicity test.Mice is divided into four groups at random, often organizes 10, male and female half and half, i.e. matched group and 3 administration groups, fasting 12 hours before experiment; The instant particles as Chinese medicine of embodiments of the invention 1 to 3 is dissolved in water respectively, (concentration is 10g crude drug/ml to give 3 administration group gavages respectively, maximum concentration), gavage volume is 10ml/kg (namely unit dosage form is crude drug 100g/kg), matched group gives normal saline, administration in a day 3 times, delivery time 4 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage instant particles as Chinese medicine LD50>100 crude drug/kg of the present invention, every day, maximum dosage-feeding was 300 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 30g crude drug/day/people, adult body weight in 60KG, average dosage is 0.5g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 22.5g) oral administration gavage electuary of the present invention is 600 times of quantity.Therefore instant particles as Chinese medicine toxicity of the present invention is low, clinical drug safety.

Embodiment 4 clinical example

300 constipation patients participate in instant particles as Chinese medicine of the present invention on probation, patient's cardinal symptom be defecation smooth, have sense of obstruction, how many patients are associated with the abdominal distention of varying degree, the symptom of stomachache, experimenter is divided into 3 groups at random, instant particles as Chinese medicine respectively in embodiment 1 to 3 on probation, be a course for the treatment of with 30 days, investigate the effect of product of the present invention treatment constipation relieving, the standard of curative effect evaluation is as follows:

Effective: defecation 1 time or more in 2 days, discharge more unobstructed, need by cathartic medicine, stomachache, abdominal distention symptom are alleviated to some extent, and drug withdrawal is after one month, and constipation symptom is without recurrence;

Invalid: whole body and local symptom are all without improvement.

Curative effect statistical result is as follows:

	Embodiment 1	Embodiment 2	Embodiment 3
				Effectively	93	98	96
Invalid	7	2	4
				Effective percentage (%)	93	98	96

Experimental result shows, instant particles as Chinese medicine of the present invention has treats anti-constipation effect preferably, patient at period in a medicine all without the untoward reaction such as diarrhoea, stomachache, gastrointestinal dysfunction.

Typical clinical case:

Zhang, man, 40 years old, symptom is that defecation is smooth, abdominal distention, stomachache, defecation time be 2 days once, take the instant particles as Chinese medicine of the embodiment of the present invention 1, become effective after taking 7, after taking 1 course for the treatment of, stool lubrication is unobstructed, and the constipation symptom such as abdominal distention, stomachache disappears, and follows up a case by regular visits to half a year without recurrence.

Lee, female, 38 years old, defecation is difficult, effort, stomachache, abdominal distention, constipation with dry stool, take the instant particles as Chinese medicine of the embodiment of the present invention 2, become effective after taking 3, after taking 1 course for the treatment of, defecation is smooth and easy, abdominal distention, stomachache alleviate, and take 3 courses for the treatment of, and stool lubrication is unobstructed, the constipation symptom such as abdominal distention, stomachache disappears, and follows up a case by regular visits to 1 year without recurrence.

River, man, 28 years old, defecation was difficult, effort, stomachache, abdominal distention, defecation are not smooth, take the instant particles as Chinese medicine of the embodiment of the present invention 3, take the same day and namely become effective, after taking 1 course for the treatment of, stool lubrication is unobstructed, and the constipation symptom such as abdominal distention, stomachache disappears, and follows up a case by regular visits to half a year without recurrence.

Above embodiment is only for illustrating technical conceive of the present invention and feature; its object is to allow person skilled in the art understand content of the present invention and to be implemented; can not limit the scope of the invention with this; all equivalences done according to spirit of the present invention change or modify, and all should be encompassed in protection scope of the present invention.

Claims (5)

1. treat an instant particles as Chinese medicine for constipation, it is characterized in that, crude drug composition and the parts by weight thereof of making described electuary comprise: long shoot Fructus Vitis viniferae Caulerpa 25-35 part, Folium Sennae 8-10 part, Aloe 10-15 part, Radix Glycyrrhizae Preparata 9-12 part, Semen Sesami Nigrum 5-9 part, Herba Solani Surattensis 6-8 part, Radix Angelicae Sinensis 6-9 part, Semen Cassiae 5-8 part, Poria 6-9 part, Radix Asparagi 5-8 part, Fructus Fici 9-12 part, Rhizoma Steudnerae Henryanae 20-25 part, Bulbus Allii Cepae 8-10 part, Pleurotus ostreatus 8-12 part.

2. a kind of instant particles as Chinese medicine for the treatment of constipation as claimed in claim 1, is characterized in that, crude drug composition and the parts by weight thereof of making described electuary comprise: long shoot Fructus Vitis viniferae Caulerpa 25 parts, Folium Sennae 8 parts, Aloe 10 parts, Radix Glycyrrhizae Preparata 9 parts, Semen Sesami Nigrum 5 parts, Herba Solani Surattensis 6 parts, Radix Angelicae Sinensis 6 parts, Semen Cassiae 5 parts, 6 parts, Poria, Radix Asparagi 5 parts, Fructus Fici 9 parts, Rhizoma Steudnerae Henryanae 20 parts, Bulbus Allii Cepae 8 parts, Pleurotus ostreatus 8 parts.

3. a kind of instant particles as Chinese medicine for the treatment of constipation as claimed in claim 1, is characterized in that, crude drug composition and the parts by weight thereof of making described electuary comprise: long shoot Fructus Vitis viniferae Caulerpa 30 parts, Folium Sennae 9 parts, Aloe 12 parts, Radix Glycyrrhizae Preparata 11 parts, Semen Sesami Nigrum 7 parts, Herba Solani Surattensis 7 parts, Radix Angelicae Sinensis 7 parts, Semen Cassiae 6 parts, 8 parts, Poria, Radix Asparagi 7 parts, Fructus Fici 11 parts, Rhizoma Steudnerae Henryanae 22 parts, Bulbus Allii Cepae 9 parts, Pleurotus ostreatus 10 parts.

4. a kind of instant particles as Chinese medicine for the treatment of constipation as claimed in claim 1, is characterized in that, crude drug composition and the parts by weight thereof of making described electuary comprise: long shoot Fructus Vitis viniferae Caulerpa 35 parts, Folium Sennae 10 parts, Aloe 15 parts, Radix Glycyrrhizae Preparata 12 parts, Semen Sesami Nigrum 9 parts, Herba Solani Surattensis 8 parts, Radix Angelicae Sinensis 9 parts, Semen Cassiae 8 parts, 9 parts, Poria, Radix Asparagi 8 parts, Fructus Fici 12 parts, Rhizoma Steudnerae Henryanae 25 parts, Bulbus Allii Cepae 10 parts, Pleurotus ostreatus 12 parts.

5. the preparation method of the instant particles as Chinese medicine of any one the treatment constipation as described in Claims 1-4, is characterized in that: comprise the following steps:

(1) Rhizoma Steudnerae Henryanae is cleaned the cube fritter that peeling is cut into length of side 2cm and is cooked at 100 DEG C of steaming and decocting 20min, long shoot Fructus Vitis viniferae Caulerpa, Semen Sesami Nigrum, Pleurotus ostreatus are cleaned, fritter is cut in Bulbus Allii Cepae peeling, and the ripe Rhizoma Steudnerae Henryanae handled well, long shoot Fructus Vitis viniferae Caulerpa, Semen Sesami Nigrum, Bulbus Allii Cepae, Pleurotus ostreatus are ground into 500 order mixed-powders after being mixed together lyophilization;

(2) Folium Sennae, Aloe, Radix Glycyrrhizae Preparata, Herba Solani Surattensis, Radix Angelicae Sinensis, Semen Cassiae, Poria, Radix Asparagi, Fructus Fici add the distilled water of its gross mass 4 times, soak 1 hour, slow fire boiling 1 hour, cross 500 order filter screen filtration after decocting, gained filter vacuum is concentrated into the thick paste that relative density is 1.30 ± 0.02 (60 DEG C);

(3) mixed-powder obtained in step (1) is added in thick paste obtained in step (2), mixing, granulate, dry, the instant particles as Chinese medicine of constipation must be treated.