CN106237008A - A kind of medicine treating prolapse of lumbar intervertebral disc and preparation method thereof - Google Patents
A kind of medicine treating prolapse of lumbar intervertebral disc and preparation method thereof Download PDFInfo
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- CN106237008A CN106237008A CN201610774241.0A CN201610774241A CN106237008A CN 106237008 A CN106237008 A CN 106237008A CN 201610774241 A CN201610774241 A CN 201610774241A CN 106237008 A CN106237008 A CN 106237008A
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a kind of medicine treating prolapse of lumbar intervertebral disc, it is made up of following crude drug: Radix Angelicae Sinensis 40～80 parts, Semen Cuscutae 40～80 parts, the Cortex Eucommiae 40～80 parts, Radix Dipsaci 50～90 parts, Caulis Spatholobi 30～60 parts, Rhizoma Drynariae 60～80 parts, the Radix Paeoniae Alba 40～90 parts, Rhizoma Corydalis 30～60 parts, Radix Clematidis 20～60 parts, Fructus Chaenomelis 30～70 parts, Herba Asari 40～60 parts, Rhizoma Cibotii 30～70 parts, Semen Juglandis 180～200 parts, Semen Sesami Nigrum 180～210 parts, Radix Aucklandiae (Radix Vladimiriae) 20～50 parts, Rhizoma Cyperi 30～35 parts, Mel is appropriate.The medicine of the present invention, with promoting blood circulation and stopping pain, Psoralen bone strengthening as the rule for the treatment of, disease sees degeneration of intervertebral disc, Anular disruption, and Nucleus pulposus stimulates or pressuring neural root, cauda equina nerve person.During treatment, oral, three times a day, each 1 ball (8 grams of every ball).The medicine of the present invention, has the advantage such as instant effect, evident in efficacy, taking convenience.
Description
Technical field
The present invention relates to a kind of medicine treating prolapse of lumbar intervertebral disc and preparation method thereof, belong to Chinese medicine technology neck
Territory.
Background technology
Prolapse of lumbar intervertebral disc is one of relatively conventional illness, is primarily due to lumbar intervertebral disc each several part (vertebral pulp, fiber
Ring and cartilaginous lamina), especially vertebral pulp, after having degenerative change in various degree, under the effect of external force factor, the fibre of intervertebral disc
Dimension ring breakage, nucleus pulposus in rear or intraspinal tube, causes adjacent ridge nerve root to be stung from rupturing part prominent (or abjection)
Swash or compressing, thus produce flank pain, a series of clinical symptoms such as side lower limb or double numbness of lower limbs, pain.
At present, it is many based on physical therapy or operation to treat prolapse of lumbar intervertebral disc in prior art, and physical therapy is cured the symptoms, not the disease, and one
As can only alleviate the state of an illness, do not reach preferable therapeutic effect.Surgery cost is high, and value-at-risk is high, and postoperative effect is unsatisfactory, most
Patient is reluctant to accept.
Summary of the invention
For above-mentioned prior art, the invention provides a kind of medicine treating prolapse of lumbar intervertebral disc, evident in efficacy, this
Bright additionally provide its preparation method.
The present invention is achieved by the following technical solutions:
A kind of medicine treating prolapse of lumbar intervertebral disc, is made up of the crude drug of following weight portion: Radix Angelicae Sinensis 40～80 parts,
Semen Cuscutae 40～80 parts, the Cortex Eucommiae 40～80 parts, Radix Dipsaci 50～90 parts, Caulis Spatholobi 30～60 parts, Rhizoma Drynariae 60～80
Part, the Radix Paeoniae Alba 40～90 parts, Rhizoma Corydalis 30～60 parts, Radix Clematidis 20～60 parts, Fructus Chaenomelis 30～70 parts, Herba Asari 40～60 parts,
Rhizoma Cibotii 30～70 parts, Semen Juglandis 180～200 parts, Semen Sesami Nigrum 180～210 parts, Radix Aucklandiae (Radix Vladimiriae) 20～50 parts, Rhizoma Cyperi 30～35
Part, Mel is appropriate.
Preferably, it is made up of the crude drug of following weight portion: Radix Angelicae Sinensis 50～60 parts, Semen Cuscutae 50～60 parts,
The Cortex Eucommiae 50～70 parts, Radix Dipsaci 50～60 parts, Caulis Spatholobi 40～60 parts, Rhizoma Drynariae 60～80 parts, the Radix Paeoniae Alba 40～70 parts,
Rhizoma Corydalis 40～60 parts, Radix Clematidis 20～60 parts, Fructus Chaenomelis 30～60 parts, Herba Asari 40～50 parts, Rhizoma Cibotii 30～50 parts, core
Semen Persicae 180～200 parts, Semen Sesami Nigrum 180～210 parts, Radix Aucklandiae (Radix Vladimiriae) 20～50 parts, Rhizoma Cyperi 30～35 parts, Mel is appropriate.
Most preferably, it is made up of the crude drug of following weight portion: Radix Angelicae Sinensis 60 parts, Semen Cuscutae 60 parts, the Cortex Eucommiae 60 parts,
Radix Dipsaci 60 parts, Caulis Spatholobi 60 parts, Rhizoma Drynariae 60 parts, the Radix Paeoniae Alba 60 parts, Rhizoma Corydalis 45 parts, Radix Clematidis 45 parts, Fructus Chaenomelis 45 parts, Herba Asari
45 parts, Rhizoma Cibotii 45 parts, Semen Juglandis 200 parts, Semen Sesami Nigrum 200 parts, Radix Aucklandiae (Radix Vladimiriae) 30 parts, Rhizoma Cyperi 30 parts, Mel is appropriate.
The preparation method of the medicine of described treatment prolapse of lumbar intervertebral disc, comprises the following steps:
(1) Rhizoma Drynariae, Rhizoma Cibotii, Semen Juglandis and Semen Sesami Nigrum are mixed, pulverize, cross 100 mesh sieves and obtain fine powder, standby；
(2) by Radix Angelicae Sinensis, Semen Cuscutae, the Cortex Eucommiae, Radix Dipsaci, Caulis Spatholobi, the Radix Paeoniae Alba, Rhizoma Corydalis, Radix Clematidis, Fructus Chaenomelis, Herba Asari, Radix Aucklandiae (Radix Vladimiriae)
Mix with Rhizoma Cyperi, by 80% ethanol solution (percetage by weight) heating and refluxing extraction 3 times, each 2 hours, 80% second of addition every time
The amount of alcoholic solution is followed successively by medical material weight (medical material used in referring to this step, i.e. Radix Angelicae Sinensis, Semen Cuscutae, the Cortex Eucommiae, Radix Dipsaci, chicken
The gross weight of Caulis seu Radix Schisandrae Henryi, the Radix Paeoniae Alba, Rhizoma Corydalis, Radix Clematidis, Fructus Chaenomelis, Herba Asari, Radix Aucklandiae (Radix Vladimiriae) and Rhizoma Cyperi) 10 times, 8 times, 6 times；Merge three
Secondary extracting solution, filters to obtain filtering residue and filtrate, standby；
(3) step (2) gained medicinal residues, extract 3 times by water (purified water) heated and boiled successively, and each 1 hour, each water consumption depended on
Secondary for medicinal residues weight 10 times, 6 times, 4 times；Merging the extracting solution of three times, filter, filtrate concentrates and (is concentrated into crude drug gross weight
2 times), merge with step (2) gained filtrate, adjust concentration of alcohol to 60%(percetage by weight), stand 10～14 hours, mistake
Filter, obtains supernatant, reclaims ethanol, is concentrated into thick paste, is dried (being dried in baking oven, temperature 80 DEG C), obtains extract；
(4) mix mixing by extract obtained for step (3) with step (1) gained fine powder, obtain mixture, add Mel (mixture
It is 1:0.8～3 with the weight ratio of Mel), making pellets by mixing medical powder with honey (routine techniques), to obtain final product.
The medicine of the treatment prolapse of lumbar intervertebral disc of the present invention, cures mainly prolapse of lumbar intervertebral disc, with promoting blood circulation and stopping pain, Psoralen bone strengthening is
The rule for the treatment of, disease sees degeneration of intervertebral disc, Anular disruption, Nucleus pulposus stimulation or pressuring neural root, cauda equina nerve person.During treatment, mouth
Clothes, three times a day, each 1 ball (8 grams of every ball), yellow wine or boiled water take；15 days courses for the treatment of, 1～2 course for the treatment of can substantially see
Effect, can cure the lighter 3～5 courses for the treatment of, and severe one 7～10 courses for the treatment of can cure.The medicine of the present invention, have instant effect, curative effect show
The advantages such as work, taking convenience.
The medicine of the treatment prolapse of lumbar intervertebral disc of the present invention, the pharmaceutical characteristic of each crude drug of employing is as follows:
Radix Angelicae Sinensis: tonifying blood and regulating menstruation, cold expelling of invigorating blood circulation, reducing swelling and alleviating pain granulation promoting, loosening bowel to relieve constipation.For key medicine of enriching blood, gynecological's key medicine, also it is outward
Section's common medicine.
Semen Cuscutae: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.
The Cortex Eucommiae: invigorating the liver and kidney, controls spinal column ache, foot and knee flaccidity, dribbling urination, and uncontrolled urination is itched, hypertension, antiabortive.
Radix Dipsaci: aching pain in waist and back；Podomere flaccidity syndrome and arthralgia syndrome；Fall and flutter wound, damage muscle folding bone, fetal movement red, the metrorrhagia of leakage, seminal emission, leukorrhagia, carbuncle
Cellulitis skin ulcer swells.
Caulis Spatholobi: there is relaxing muscles and tendons to promote blood circulation, effect of nourishing blood for regulating menstruation；Cure mainly rheumatic arthralgia, numb hand and foot, quadriplegia, the moon
Through uncomfortable, blockage of menstruation, dysmenorrhea, amenorrhea, leukopenia.
Rhizoma Drynariae: the kidney invigorating bone strengthening, continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, muscles and bones
Injured；External treatment alopecia areata, vitiligo.
The Radix Paeoniae Alba: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.For dizziness of having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency
Sallow, menoxenia, spontaneous perspiration, night sweat.
Rhizoma Corydalis: invigorate blood circulation；Dissipating blood stasis；Regulate the flow of vital energy；Pain relieving.Main trusted subordinate's all pains of waist knee joint；Menoxenia；Lump in the abdomen；Metrorrhagia；Puerperal blood
Dizzy；Lochiorrhea；Traumatic injury.
Radix Clematidis: for rheumatic arthralgia, numb limbs and tense tendons, muscle arteries and veins contracture, joint stuffiness, bone is choked with sobs larynx.
Fructus Chaenomelis: relieve the effect of alcohol, remove expectorant, pleasant, dysentery relieving.
Herba Asari: relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping, sensible, warming the lung to resolve fluid-retention.For anemofrigid cold, headache, toothache, watery nasal discharge of having a stuffy nose,
Allergic rhinitis, nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.
Rhizoma Cibotii: for rheumatic arthralgia, soreness of the waist and knees, weakness of the lower extremities.
Semen Juglandis: the kidney invigorating warming the lung, loosening bowel to relieve constipation.
Semen Sesami Nigrum: invigorating the liver and kidney, grows the five internal organs, and benefiting essence-blood, intestine moistening is dry.
Radix Aucklandiae (Radix Vladimiriae): promoting the circulation of QI to relieve pain, regulates the flow of vital energy soothing the liver.
Rhizoma Cyperi: dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated.
The medicine of embodiment 1 preparation treatment prolapse of lumbar intervertebral disc
Formula is: Radix Angelicae Sinensis 60 grams, Semen Cuscutae 60 grams, the Cortex Eucommiae 60 grams, Radix Dipsaci 60 grams, Caulis Spatholobi 60 grams, Rhizoma Drynariae 60 grams, in vain
Chinese herbaceous peony 60 grams, Rhizoma Corydalis 45 grams, Radix Clematidis 45 grams, Fructus Chaenomelis 45 grams, Herba Asari 45 grams, Rhizoma Cibotii 45 grams, Semen Juglandis 200 grams, Semen Sesami Nigrum 200
Gram, Radix Aucklandiae (Radix Vladimiriae) 30 grams, Rhizoma Cyperi 30 grams, Mel is appropriate.
Preparation method is as follows:
(1) Rhizoma Drynariae, Rhizoma Cibotii, Semen Juglandis and Semen Sesami Nigrum are mixed, pulverize, cross 100 mesh sieves and obtain fine powder, standby；
(2) by Radix Angelicae Sinensis, Semen Cuscutae, the Cortex Eucommiae, Radix Dipsaci, Caulis Spatholobi, the Radix Paeoniae Alba, Rhizoma Corydalis, Radix Clematidis, Fructus Chaenomelis, Herba Asari, Radix Aucklandiae (Radix Vladimiriae)
Mixing with Rhizoma Cyperi, by 80% ethanol solution heating and refluxing extraction 3 times, each 2 hours, the amount of 80% ethanol solution of addition depended on every time
Secondary for medical material weight (referring to medical material used in this step) 10 times, 8 times, 6 times；Merge the extracting solution of three times, filter to obtain filtering residue
And filtrate, standby；
(3) step (2) gained medicinal residues, extract 3 times by purified water heated and boiled successively, and each 1 hour, each water consumption was followed successively by
10 times of medicinal residues weight, 6 times, 4 times；Merging the extracting solution of three times, filter, filtrate concentrates and (is concentrated into the 2 of crude drug gross weight
Times), merging with step (2) gained filtrate, adjustment concentration of alcohol, to 60%, stands 12 hours, filters, and obtains supernatant, reclaims second
Alcohol, is concentrated into thick paste, is dried (being dried in baking oven, temperature 80 DEG C), obtains extract；
(4) mix mixing by extract obtained for step (3) with step (1) gained fine powder, obtain mixture, add mixture weight 1
Mel again, making pellets by mixing medical powder with honey (8 grams of every ball), to obtain final product.
The medicine of embodiment 2 preparation treatment prolapse of lumbar intervertebral disc
Formula is: Radix Angelicae Sinensis 50 grams, Semen Cuscutae 50 grams, the Cortex Eucommiae 50 grams, Radix Dipsaci 50 grams, Caulis Spatholobi 40 grams, Rhizoma Drynariae
80 grams, the Radix Paeoniae Alba 70 grams, Rhizoma Corydalis 60 grams, Radix Clematidis 60 grams, Fructus Chaenomelis 30 grams, Herba Asari 40 grams, Rhizoma Cibotii 30 grams, Semen Juglandis 180
Gram, Semen Sesami Nigrum 180 grams, Radix Aucklandiae (Radix Vladimiriae) 50 grams, Rhizoma Cyperi 35 grams, Mel is appropriate.
Preparation method is as follows:
(1) Rhizoma Drynariae, Rhizoma Cibotii, Semen Juglandis and Semen Sesami Nigrum are mixed, pulverize, cross 100 mesh sieves and obtain fine powder, standby；
(2) by Radix Angelicae Sinensis, Semen Cuscutae, the Cortex Eucommiae, Radix Dipsaci, Caulis Spatholobi, the Radix Paeoniae Alba, Rhizoma Corydalis, Radix Clematidis, Fructus Chaenomelis, Herba Asari, Radix Aucklandiae (Radix Vladimiriae)
Mixing with Rhizoma Cyperi, by 80% ethanol solution heating and refluxing extraction 3 times, each 2 hours, the amount of 80% ethanol solution of addition depended on every time
Secondary for medical material weight (referring to medical material used in this step) 10 times, 8 times, 6 times；Merge the extracting solution of three times, filter to obtain filtering residue
And filtrate, standby；
(3) step (2) gained medicinal residues, extract 3 times by purified water heated and boiled successively, and each 1 hour, each water consumption was followed successively by
10 times of medicinal residues weight, 6 times, 4 times；Merging the extracting solution of three times, filter, filtrate concentrates and (is concentrated into the 2 of crude drug gross weight
Times), merging with step (2) gained filtrate, adjustment concentration of alcohol, to 60%, stands 12 hours, filters, and obtains supernatant, reclaims second
Alcohol, is concentrated into thick paste, is dried (being dried in baking oven, temperature 80 DEG C), obtains extract；
(4) mix mixing by extract obtained for step (3) with step (1) gained fine powder, obtain mixture, add mixture weight
The Mel of 1.5 times, making pellets by mixing medical powder with honey (8 grams of every ball), to obtain final product.
The medicine of embodiment 3 preparation treatment prolapse of lumbar intervertebral disc
Formula is: Radix Angelicae Sinensis 55 grams, Semen Cuscutae 55 grams, the Cortex Eucommiae 60 grams, Radix Dipsaci 55 grams, Caulis Spatholobi 50 grams, Rhizoma Drynariae
70 grams, the Radix Paeoniae Alba 50 grams, Rhizoma Corydalis 50 grams, Radix Clematidis 40 grams, Fructus Chaenomelis 50 grams, Herba Asari 45 grams, Rhizoma Cibotii 40 grams, Semen Juglandis
190 grams, Semen Sesami Nigrum 190 grams, Radix Aucklandiae (Radix Vladimiriae) 40 grams, Rhizoma Cyperi 33 grams, Mel is appropriate.
Preparation method is as follows:
(1) Rhizoma Drynariae, Rhizoma Cibotii, Semen Juglandis and Semen Sesami Nigrum are mixed, pulverize, cross 100 mesh sieves and obtain fine powder, standby；
(2) by Radix Angelicae Sinensis, Semen Cuscutae, the Cortex Eucommiae, Radix Dipsaci, Caulis Spatholobi, the Radix Paeoniae Alba, Rhizoma Corydalis, Radix Clematidis, Fructus Chaenomelis, Herba Asari, Radix Aucklandiae (Radix Vladimiriae)
Mixing with Rhizoma Cyperi, by 80% ethanol solution heating and refluxing extraction 3 times, each 2 hours, the amount of 80% ethanol solution of addition depended on every time
Secondary for medical material weight (referring to medical material used in this step) 10 times, 8 times, 6 times；Merge the extracting solution of three times, filter to obtain filtering residue
And filtrate, standby；
(3) step (2) gained medicinal residues, extract 3 times by purified water heated and boiled successively, and each 1 hour, each water consumption was followed successively by
10 times of medicinal residues weight, 6 times, 4 times；Merging the extracting solution of three times, filter, filtrate concentrates and (is concentrated into the 2 of crude drug gross weight
Times), merging with step (2) gained filtrate, adjustment concentration of alcohol, to 60%, stands 12 hours, filters, and obtains supernatant, reclaims second
Alcohol, is concentrated into thick paste, is dried (being dried in baking oven, temperature 80 DEG C), obtains extract；
(4) mix mixing by extract obtained for step (3) with step (1) gained fine powder, obtain mixture, add mixture weight 1
Mel again, making pellets by mixing medical powder with honey (8 grams of every ball), to obtain final product.
The medicine of embodiment 4 preparation treatment prolapse of lumbar intervertebral disc
Formula is: Radix Angelicae Sinensis 40 grams, Semen Cuscutae 80 grams, the Cortex Eucommiae 40 grams, Radix Dipsaci 90 grams, Caulis Spatholobi 30 grams, Rhizoma Drynariae
80 grams, the Radix Paeoniae Alba 40 grams, Rhizoma Corydalis 60 grams, Radix Clematidis 20 grams, Fructus Chaenomelis 70 grams, Herba Asari 40 grams, Rhizoma Cibotii 70 grams, Semen Juglandis
180 grams, Semen Sesami Nigrum 210 grams, Radix Aucklandiae (Radix Vladimiriae) 20 grams, Rhizoma Cyperi 35 grams, Mel is appropriate.
Preparation method is as follows:
(1) Rhizoma Drynariae, Rhizoma Cibotii, Semen Juglandis and Semen Sesami Nigrum are mixed, pulverize, cross 100 mesh sieves and obtain fine powder, standby；
(2) by Radix Angelicae Sinensis, Semen Cuscutae, the Cortex Eucommiae, Radix Dipsaci, Caulis Spatholobi, the Radix Paeoniae Alba, Rhizoma Corydalis, Radix Clematidis, Fructus Chaenomelis, Herba Asari, Radix Aucklandiae (Radix Vladimiriae)
Mixing with Rhizoma Cyperi, by 80% ethanol solution heating and refluxing extraction 3 times, each 2 hours, the amount of 80% ethanol solution of addition depended on every time
Secondary for medical material weight (referring to medical material used in this step) 10 times, 8 times, 6 times；Merge the extracting solution of three times, filter to obtain filtering residue
And filtrate, standby；
(3) step (2) gained medicinal residues, extract 3 times by purified water heated and boiled successively, and each 1 hour, each water consumption was followed successively by
10 times of medicinal residues weight, 6 times, 4 times；Merging the extracting solution of three times, filter, filtrate concentrates and (is concentrated into the 2 of crude drug gross weight
Times), merging with step (2) gained filtrate, adjustment concentration of alcohol, to 60%, stands 12 hours, filters, and obtains supernatant, reclaims second
Alcohol, is concentrated into thick paste, is dried (being dried in baking oven, temperature 80 DEG C), obtains extract；
(4) mix mixing by extract obtained for step (3) with step (1) gained fine powder, obtain mixture, add mixture weight 2
Mel again, making pellets by mixing medical powder with honey (8 grams of every ball), to obtain final product.
The medicine of embodiment 5 preparation treatment prolapse of lumbar intervertebral disc
Formula is: Radix Angelicae Sinensis 80 grams, Semen Cuscutae 40 grams, the Cortex Eucommiae 80 grams, Radix Dipsaci 50 grams, Caulis Spatholobi 60 grams, Rhizoma Drynariae 60
Gram, the Radix Paeoniae Alba 90 grams, Rhizoma Corydalis 30 grams, Radix Clematidis 60 grams, Fructus Chaenomelis 30 grams, Herba Asari 60 grams, Rhizoma Cibotii 30 grams, Semen Juglandis 200
Gram, Semen Sesami Nigrum 180 grams, Radix Aucklandiae (Radix Vladimiriae) 50 grams, Rhizoma Cyperi 30 grams, Mel is appropriate.
Preparation method is as follows:
(1) Rhizoma Drynariae, Rhizoma Cibotii, Semen Juglandis and Semen Sesami Nigrum are mixed, pulverize, cross 100 mesh sieves and obtain fine powder, standby；
(2) by Radix Angelicae Sinensis, Semen Cuscutae, the Cortex Eucommiae, Radix Dipsaci, Caulis Spatholobi, the Radix Paeoniae Alba, Rhizoma Corydalis, Radix Clematidis, Fructus Chaenomelis, Herba Asari, Radix Aucklandiae (Radix Vladimiriae)
Mixing with Rhizoma Cyperi, by 80% ethanol solution heating and refluxing extraction 3 times, each 2 hours, the amount of 80% ethanol solution of addition depended on every time
Secondary for medical material weight (referring to medical material used in this step) 10 times, 8 times, 6 times；Merge the extracting solution of three times, filter to obtain filtering residue
And filtrate, standby；
(3) step (2) gained medicinal residues, extract 3 times by purified water heated and boiled successively, and each 1 hour, each water consumption was followed successively by
10 times of medicinal residues weight, 6 times, 4 times；Merging the extracting solution of three times, filter, filtrate concentrates and (is concentrated into the 2 of crude drug gross weight
Times), merging with step (2) gained filtrate, adjustment concentration of alcohol, to 60%, stands 12 hours, filters, and obtains supernatant, reclaims second
Alcohol, is concentrated into thick paste, is dried (being dried in baking oven, temperature 80 DEG C), obtains extract；
(4) mix mixing by extract obtained for step (3) with step (1) gained fine powder, obtain mixture, add mixture weight 3
Mel again, making pellets by mixing medical powder with honey (8 grams of every ball), to obtain final product.
Clinical statistics data:
Patient data: from 2005 so far, altogether treatment prolapse of lumbar intervertebral disc patient 395 example, age 22～50 years old 312 example, 50 years old
Above person 83 example；Man's 286 examples, female 109 example.
Therapeutic Method: the honeyed pill of oral embodiment 1 preparation, three times a day, each 1 ball, yellow wine or boiled water take；15 days
One course for the treatment of.Statistics curative effect (period healing person continues 1 course for the treatment of of medication, to consolidate curative effect) is observed after 4 months.
The standard of curative effect evaluation: with reference to criterion of therapeutical effect relevant in " disease of tcm judgement criterion of therapeutical effect ".
Cure: clinical symptoms all disappears, and lab testing is normal.
Effective: clinical symptoms disappears substantially, test chamber checks that each index of correlation is close to normal level.
Effective: clinical symptom relief, test chamber checks that each index of correlation makes moderate progress, and sign has improvement.
Invalid: clinical symptoms is without being clearly better or increasing the weight of.
Therapeutic outcome: after 5 courses for the treatment of, cures 268 examples (67.8%), effective 83 examples, effective 38 examples, invalid 6 examples.Effective, have
Effect, nonresponder's totally 127 example, continue medication, after 8 courses for the treatment of (referring to total course for the treatment of), in this 127 example patient, cures again 68 examples, and effective 44
Example, effective 13 examples, invalid 2 examples.
That is: use the Drug therapy of the present invention, after 8 courses for the treatment of, cure 336 examples (85.1%) altogether, effective 44 examples (11.1%),
Effective 13 examples (3.3%), invalid 2 examples, total effective rate 99.5%.
Model case:
Case 1: Zheng, man, 37 years old, Lumbar scoliosis, waist limitation of activity, sitting pain in the lumbar region, take the oral administration syrup that embodiment 1 prepares
Pill, three times a day, each 8g, after 10 days, symptom is obviously improved, and flank pain sense alleviates.
Case 2: Lee, man, 43 years old, waist, leg pain, cough, sneeze or when carrying weight pain increase the weight of, it is impossible to complete
Entirely walking upright, take the oral administration syrup pill that embodiment 1 prepares, three times a day, each 8g, after 12 days, the pain in the lumbar region symptom that has a pain in the leg is obvious
Alleviating, walking tends to normal.
Case 3: Zhang, female, 52 years old, buttocks, leg pain, moving obstacle, take the oral honeyed pill that embodiment 1 prepares
Agent, three times a day, each 8g, after 10 days, symptom substantially alleviates, and buttocks, leg pain sense alleviate, and moving obstacle has clear improvement.
Claims (7)
1. the medicine treating prolapse of lumbar intervertebral disc, it is characterised in that: it is made up of the crude drug of following weight portion: entirely work as
Return 40～80 parts, Semen Cuscutae 40～80 parts, the Cortex Eucommiae 40～80 parts, Radix Dipsaci 50～90 parts, Caulis Spatholobi 30～60 parts, bone
Broken benefit 60～80 parts, the Radix Paeoniae Alba 40～90 parts, Rhizoma Corydalis 30～60 parts, Radix Clematidis 20～60 parts, Fructus Chaenomelis 30～70 parts, carefully
Pungent 40～60 parts, Rhizoma Cibotii 30～70 parts, Semen Juglandis 180～200 parts, Semen Sesami Nigrum 180～210 parts, Radix Aucklandiae (Radix Vladimiriae) 20～50 parts,
Rhizoma Cyperi 30～35 parts, Mel is appropriate.
The medicine for the treatment of prolapse of lumbar intervertebral disc the most according to claim 1, it is characterised in that: it is former by following weight portion
Material medicine is made: Radix Angelicae Sinensis 50～60 parts, Semen Cuscutae 50～60 parts, the Cortex Eucommiae 50～70 parts, Radix Dipsaci 50～60 parts, Sanguis Gallus domesticus
Rattan 40～60 parts, Rhizoma Drynariae 60～80 parts, the Radix Paeoniae Alba 40～70 parts, Rhizoma Corydalis 40～60 parts, Radix Clematidis 20～60 parts, wood
Melon 30～60 parts, Herba Asari 40～50 parts, Rhizoma Cibotii 30～50 parts, Semen Juglandis 180～200 parts, Semen Sesami Nigrum 180～210 parts, extensively
The Radix Aucklandiae 20～50 parts, Rhizoma Cyperi 30～35 parts, Mel is appropriate.
The medicine for the treatment of prolapse of lumbar intervertebral disc the most according to claim 1, it is characterised in that: it is former by following weight portion
Material medicine is made: Radix Angelicae Sinensis 60 parts, Semen Cuscutae 60 parts, the Cortex Eucommiae 60 parts, Radix Dipsaci 60 parts, Caulis Spatholobi 60 parts, Rhizoma Drynariae 60 parts, in vain
Chinese herbaceous peony 60 parts, Rhizoma Corydalis 45 parts, Radix Clematidis 45 parts, Fructus Chaenomelis 45 parts, Herba Asari 45 parts, Rhizoma Cibotii 45 parts, Semen Juglandis 200 parts, Semen Sesami Nigrum 200
Part, Radix Aucklandiae (Radix Vladimiriae) 30 parts, Rhizoma Cyperi 30 parts, Mel is appropriate.
4. according to the medicine of the treatment prolapse of lumbar intervertebral disc according to any one of claims 1 to 3, it is characterised in that: it is to pass through
Following methods prepares:
(1) Rhizoma Drynariae, Rhizoma Cibotii, Semen Juglandis and Semen Sesami Nigrum are mixed, pulverize, cross 100 mesh sieves and obtain fine powder, standby；
(2) by Radix Angelicae Sinensis, Semen Cuscutae, the Cortex Eucommiae, Radix Dipsaci, Caulis Spatholobi, the Radix Paeoniae Alba, Rhizoma Corydalis, Radix Clematidis, Fructus Chaenomelis, Herba Asari, Radix Aucklandiae (Radix Vladimiriae)
Mixing with Rhizoma Cyperi, by 80% ethanol solution heating and refluxing extraction 3 times, each 2 hours, the amount of 80% ethanol solution of addition depended on every time
Secondary for medical material weight 10 times, 8 times, 6 times；Merge the extracting solution of three times, filter to obtain filtering residue and filtrate, standby；
(3) step (2) gained medicinal residues, extract 3 times by water heated and boiled successively, and each 1 hour, each water consumption was followed successively by medicinal residues
10 times of weight, 6 times, 4 times；Merging the extracting solution of three times, filter, filtrate concentrates, and merges with step (2) gained filtrate, adjusts
Concentration of alcohol, to 60%, stands 10～14 hours, filters, and obtains supernatant, reclaims ethanol, is concentrated into thick paste, is dried, obtains extract；
(4) mixing mixing by extract obtained for step (3) with step (1) gained fine powder, obtain mixture, add Mel, refined honey is
Ball, to obtain final product.
The medicine for the treatment of prolapse of lumbar intervertebral disc the most according to claim 4, it is characterised in that: in described step (4), mixing
Thing is 1:0.8～3 with the weight ratio of Mel.
6. the preparation method of the medicine of the treatment prolapse of lumbar intervertebral disc according to any one of Claims 1 to 4, it is characterised in that:
Comprise the following steps:
(1) Rhizoma Drynariae, Rhizoma Cibotii, Semen Juglandis and Semen Sesami Nigrum are mixed, pulverize, cross 100 mesh sieves and obtain fine powder, standby；
(2) by Radix Angelicae Sinensis, Semen Cuscutae, the Cortex Eucommiae, Radix Dipsaci, Caulis Spatholobi, the Radix Paeoniae Alba, Rhizoma Corydalis, Radix Clematidis, Fructus Chaenomelis, Herba Asari, Radix Aucklandiae (Radix Vladimiriae)
Mixing with Rhizoma Cyperi, by 80% ethanol solution heating and refluxing extraction 3 times, each 2 hours, the amount of 80% ethanol solution of addition depended on every time
Secondary for medical material weight 10 times, 8 times, 6 times；Merge the extracting solution of three times, filter to obtain filtering residue and filtrate, standby；
(3) step (2) gained medicinal residues, extract 3 times by water heated and boiled successively, and each 1 hour, each water consumption was followed successively by medicinal residues
10 times of weight, 6 times, 4 times；Merging the extracting solution of three times, filter, filtrate concentrates, and merges with step (2) gained filtrate, adjusts
Concentration of alcohol, to 60%, stands 10～14 hours, filters, and obtains supernatant, reclaims ethanol, is concentrated into thick paste, is dried, obtains extract；
(4) mixing mixing by extract obtained for step (3) with step (1) gained fine powder, obtain mixture, add Mel, refined honey is
Ball, to obtain final product.
Preparation method the most according to claim 6, it is characterised in that: in described step (4), mixture and the weight of Mel
Ratio is 1:0.8～3.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113559198A (en) * | 2020-04-23 | 2021-10-29 | 杨守信 | Medicine special for treating lumbar disc herniation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991742A (en) * | 2010-10-20 | 2011-03-30 | 刘思波 | Traditional Chinese medicine formula for treating lumbar disc herniation |
| CN102824500A (en) * | 2012-09-19 | 2012-12-19 | 窦小伟 | Traditional Chinese medicine for treating protrusion of lumbar intervertebral disc and osteoproliferation |
-
2016
- 2016-08-31 CN CN201610774241.0A patent/CN106237008A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991742A (en) * | 2010-10-20 | 2011-03-30 | 刘思波 | Traditional Chinese medicine formula for treating lumbar disc herniation |
| CN102824500A (en) * | 2012-09-19 | 2012-12-19 | 窦小伟 | Traditional Chinese medicine for treating protrusion of lumbar intervertebral disc and osteoproliferation |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113559198A (en) * | 2020-04-23 | 2021-10-29 | 杨守信 | Medicine special for treating lumbar disc herniation |
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