CN104958531A - Traditional Chinese medicine preparation for treating migraine and preparation method of traditional Chinese medicine preparation - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating migraine. The traditional Chinese medicine preparation is prepared from the following main raw materials in parts by weight: 3-9 parts of radix bupleuri, 5-9 parts of atractylodes macrocephala, 1-5 parts of mint, 2-6 parts of caulis spatholobi, 1-3 parts of polygala tenuifolia, 3-7 parts of semen brassicae, 4-6 parts of rose, 2-4 parts of slender acanthopanax, 5-15 parts of lily, 5-9 parts of folium artemisiae argyi, 3-6 parts of apocynum venetum, 1-3 parts of crape myrtle roots, 6-10 parts of fructus piperis longi, 3-8 parts of wild chrysanthemum flower and 10-15 parts of arisaema cum bile. Based on the principle of syndrome differentiation prevention and treatment of the traditional Chinese medicine, the traditional Chinese medicine preparation disclosed by the invention is relatively comprehensive in treatment and long-lasting in medicinal effect, is a migraine formula which takes both internal treatment and external treatment into account as volatile oil is externally used, that is, rubbed at headache parts and massaged for 3 circles leftwards and rightwards respectively together with an oral preparation, and has a very good treatment effect on migraine.

Description

One treats migrainous Chinese medicine preparation and preparation method thereof

Technical field

The invention discloses one and treat migraine Chinese medicine preparation, especially relate to one and treat migrainous Chinese medicine preparation and preparation method thereof, the invention belongs to traditional Chinese medicine field.

Background technology

Migraine (migraine) is clinical modal primary headache type; clinical with ictal middle severe, sample of beating headache for main manifestations; headache mostly is inclined side; general lasting 4 ~ 72 hours; can with Nausea and vomiting; light, Sound stimulat or daily routines all can increase the weight of headache, and quiet environment, rest can alleviate headache.Migraine is a kind of common chronic forms vascular illness, and a lot of disease is in child and adolescence, and the young and middle-aged phase reaches onset peak, and women is common, and men and women's Proportion of patients is about 1: 2 ~ 3, and in crowd, prevalence is 5% ~ 10%, often has genetic background.

The migrainous cause of disease is still not clear, may with following factors about inherited genetic factors: the migraine patient of about 60% has family history, its relatives occur that migrainous risk is 3 ~ 6 times of population, familial migraineur not yet finds consistent mendelian inheritance, reflects the interaction of different penetrance and polygenic inheritance feature and environmental factors.Familial hemiplegia type migraine is the clear and definite autosomal dominant inheritance, AD having Height Anomalies penetrance, has been positioned at 19p13(and has suddenlyd change relevant with the voltage door P/Q calcium channel gene mistranslation that brain is expressed), three disease gene sites such as 1q21 and 1q31.E&M factor: primary disease women is more than male, and how in adolescence morbidity, menstrual phase is easily shown effect, and trimester of pregnancy or post menopausal outbreak reduce or stop.This prompting E&M factor participates in migrainous morbidity.In addition, the Developmental and Metabolic Disorder such as 5-hydroxy tryptamine (5-HT), norepinephrine, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 and arachidonic acid also can affect migraine and occurs.Diet and Nervous and Mental Factors: migraine can by some food and drug-induced, food comprises the cheese containing tyramine, the meat containing nitrite antiseptic and cure foods, containing the chocolate of phenethylamine, food additive as sodium glutamate (monosodium glutamate), red wine and wine etc.Medicine comprises oral contraceptive and vasodilation as nitroglycerin etc.Other environment and Nervous and Mental Factors such as nervous, overwork, excited, hypersomnia or very few, menstruation, high light also can bring out.

Migraine complication: (1) chronic migraine: migraine monthly Headache attacks, more than 15 days, continuous 3 months or more than 3 months, and the headache getting rid of that overdose causes, can be thought of as chronic migraine.(2) statural hemicranicus: migraine persistent period >=72 hours, and pain degree is comparatively serious, but can have the of short duration catabasis because sleep or medicinal application obtain therebetween.(3) without the lasting tendency of infarction: refer to that migraine without aura patient occurs that in once showing effect a kind of tendency or multiple premonitory symptom continue more than 1 week, mostly be bilateral; This show effect other symptoms with to show effect in the past similar; Cerebral infarction focus must be got rid of by neuroimaging.(4) migraine infarction: the ischemic infarct occurring the corresponding blood supply region of intracranial under rare occasion after migraine aura symptom, this premonitory symptom often continues more than 60 minutes, and ischemic infarct focus is confirmed by neuroimaging, be called migraine infarction.(5) the epilepsy sample that migraine is brought out shows effect: under rare occasion, migraine aura symptom can trigger epilepsy outbreak, and epilepsy outbreak occurs in premonitory symptom or within latter 1 hour.

In the migrainous patent of existing treatment, Authorization Notice No. CN 102302751 B(application number 201110238307.1) Chinese patent literature disclose one and treat migrainous Chinese medicine, it is characterized in that: be made up of the raw material of following parts by weight: Rhizoma Panacis Japonici 5-10 part, Fructus Mangifera Indicae root 3-5 part, Herba Artemisiae Anomalae 10-12 part, Herba Salomoniae Cantoniensis 4-6 part, Folium Baeckeae 4-6 part, Rhizoma Cyperi 15-20 part, Flos Rosae Rugosae 3-5 part, Radix Angelicae Sinensis 3-5 part, Herba Asari 1-3 part, Herba Menthae 3-5 part, Rhizoma Et Radix Notopterygii 3-5 part, Radix Angelicae Pubescentis 3-5 part, Radix Glycyrrhizae 1-3 part, Rhizoma Atractylodis 3-5 part, Radix Ophiopogonis 3-5 part, Radix Scutellariae 4-6 part, Bulbus Lilii 2-4 part, Flos Chrysanthemi 2-4 part, Rhizoma Zingiberis Recens fresh goods 6-8 part, preparation method: all raw materials are mixed, and with Burdick lamp, sterilization processing is carried out to it, then, put people's baking box to pharmaceutical drying, with pulverizer, medicine is pulverized, be then ground into powder face, then stir in loading hard capsule.Authorization Notice No. CN 103285262 B(application number 201310240998.8) Chinese patent literature disclose one and treat migrainous Chinese medicine, it is characterized in that, it is prepared from by the medical material of following weight portion: Radix Polygalae 6 parts, Fructus trachycarpi 12 parts, Herba Astragali Melilotoidis 5 parts, Vicia unijuga 10 parts, Fructus Aurantii Immaturus 15 parts, Folium Acanthopanacis Radicis 9 parts, Herba Apocyni veneti 12 parts, Fructus Piperis Longi 15 parts, Folium Artemisiae Argyi 8 parts.

In a word, Chinese medicine achieves good curative effect in treatment primary disease, but also there are some problems: have much room for improvement to improving the misery that migraine brings.

Summary of the invention

Along with the development of Chinese Chinese medicine, in prevention and controlling migraine, people gradually appreciate Chinese medicine and have no side effect in the migraine process of preventing and treating, patient bears painful little, and the advantage that cost is saved relatively, for the migrainous present situation of existing western medical treatment, an object of the present invention is to provide one to treat migrainous Chinese medicine preparation, there is feature easy to operate, evident in efficacy, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

One treats migrainous Chinese medicine preparation, takes off the primary raw material stating weight proportion and is prepared from: Radix Bupleuri 3-9 part, Rhizoma Atractylodis Macrocephalae 5-9 part, Herba Menthae 1-5 part, Caulis Spatholobi 2-6 part, Radix Polygalae 1-3 part, Semen Sinapis Albae 3-7 part, Flos Rosae Rugosae 4-6 part, Folium Acanthopanacis Radicis 2-4 part, Bulbus Lilii 5-15 part, Folium Artemisiae Argyi 5-9 part, Herba Apocyni veneti 3-6 part, Radix Lagerstroemia indica L. 1-3 part, Fructus Piperis Longi 6-10 part, Flos Chrysanthemi Indici 3-8 part, Arisaema Cum Bile 10-15 part.

One treats migrainous Chinese medicine preparation, preferred scheme, takes off the primary raw material stating weight proportion and is prepared from: Radix Bupleuri 5-7 part, Rhizoma Atractylodis Macrocephalae 6-8 part, Herba Menthae 2-4 part, Caulis Spatholobi 3-5 part, Radix Polygalae 1.5-2.5 part, Semen Sinapis Albae 4-6 part, Flos Rosae Rugosae 4.5-5.5 part, Folium Acanthopanacis Radicis 2.5-3.5 part, Bulbus Lilii 8-13 part, Folium Artemisiae Argyi 6-8 part, Herba Apocyni veneti 4-5 part, Radix Lagerstroemia indica L. 1.5-2.5 part, Fructus Piperis Longi 7-9 part, Flos Chrysanthemi Indici 4-7 part, Arisaema Cum Bile 11-14 part.

One treats migrainous Chinese medicine preparation, better preferred scheme, takes off the primary raw material stating weight proportion and is prepared from: Radix Bupleuri 6 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Herba Menthae 3 parts, Caulis Spatholobi 4 parts, Radix Polygalae 2 parts, Semen Sinapis Albae 5 parts, Flos Rosae Rugosae 5 parts, Folium Acanthopanacis Radicis 3 parts, Bulbus Lilii 10 parts, Folium Artemisiae Argyi 7 parts, Herba Apocyni veneti 4.5 parts, Radix Lagerstroemia indica L. 2 parts, Fructus Piperis Longi 8 parts, Flos Chrysanthemi Indici 5.5 parts, Arisaema Cum Bile 12.5 parts.

Another object of the present invention is just to provide the migrainous preparation method of above-mentioned treatment.

Treat a preparation method for migrainous Chinese medicine preparation, step is as follows:

1. Flos Chrysanthemi Indici is first used the clean water one time of room temperature, put into clean container, with the hot water of 80-100 DEG C, be dipped to the complete variable color of water, filter, filtrate is stand-by, the Rhizoma Atractylodis Macrocephalae, Herba Menthae and Folium Artemisiae Argyi are cleaned, is pounded disintegrating slag, be placed in gained filtrate, soak 40-60 minute, soaked raw material is placed in boiler, and add water in pot the dipped bed of material, and the bottom of a pan is heated, water boils post-heating 10-20 minute (preferably 15 minutes), is separated upper strata fluid and namely obtains external volatile oil;

2. Radix Bupleuri, Caulis Spatholobi, Radix Polygalae, Semen Sinapis Albae, Folium Acanthopanacis Radicis, Herba Apocyni veneti, Radix Lagerstroemia indica L., Fructus Piperis Longi and Arisaema Cum Bile are placed in marmite, add raw material weight 3-6 clear water doubly, first soak 20-40 minute, be fried open turning intense fire, intense fire puts into Flos Rosae Rugosae after boiling 2-6 minute and Bulbus Lilii is making slow fire boiling 10-30 minute into, filter, filtering residue is stand-by;

3. by step 2. gained filtering residue, again add raw material weight 2-4 hot water doubly, decoct and stir 20-40 minute, filter, obtain filtrate for subsequent use;

4. by step 2. with step 3. gained filtrate mix, cross 180-220 order drainage screen, mixing filtrate is heated to 50 DEG C, puts into filtrate weight 0.2-0.6 Mel doubly, after Mel melts completely, cools bottling and namely obtain oral formulations.

The preparation method of above-mentioned Chinese medicine preparation, 1. step uses the hot water of 85-95 DEG C, is dipped to the complete variable color of water (preferred, with the hot water of 90 DEG C, to be dipped to the complete variable color of water).

The preparation method of above-mentioned Chinese medicine preparation, 1. step soaks 45-55 minute, soaked raw material is placed in boiler (preferred, to soak 50 minutes, soaked raw material is placed in boiler).

The preparation method of above-mentioned Chinese medicine preparation, 2. step adds raw material weight 4-5 clear water doubly, first soaks 25-35 minute (preferred, to add the clear water of raw material weight 4.5 times, first soak 30 minutes).

The preparation method of above-mentioned Chinese medicine preparation, step 2. intense fire is put into Flos Rosae Rugosae and Bulbus Lilii and is being made into slow fire boiling 15-25 minute (preferred, intense fire puts into Flos Rosae Rugosae after boiling 4 minutes and Bulbus Lilii is making slow fire boiling into 20 minutes) after boiling 3-5 minute.

The preparation method of above-mentioned Chinese medicine preparation, 3. step adds raw material weight 2.5-3.5 hot water doubly again, decocts and stirs 25-35 minute (preferred, again to add the hot water of raw material weight 3 times, decoct while stir 30 minutes).

The preparation method of above-mentioned Chinese medicine preparation, 4. step crosses 190-210 order drainage screen, and mixing filtrate is heated to 50 DEG C, put into filtrate weight 0.3-0.5 Mel doubly (preferred, cross 200 order drainage screens, mixing filtrate is heated to 50 DEG C, puts into the Mel of filtrate weight 0.4 times).

This Chinese medicine preparation, to migraine Be very effective, has good mitigation, the local common medical material of multiselect of the present invention to the symptom such as dizzy, nauseating caused by migraine, cheap, alleviates the financial burden of patient.

The pharmacological effect of each crude drug is respectively:

Radix Bupleuri: Radix Bupleuri is conventional diaphoretic medicine.Another name ground smoke, mountain dish, mushroom grass, faggot, nature and flavor hardship, be slightly cold, return liver, gallbladder meridian.There is reconciling superficies and interior, effect of soothing the liver yang invigorating.For cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterine prolapse, menoxenia.

The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.Function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis is antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.。

Herba Menthae: Herba Menthae is Chinese conventional Chinese medicine, young tender stem point can make vegetable edible, and herb can be used as medicine again, and cure cold heating laryngalgia, and headache, conjunctival congestion with ophthalmalgia, myalgia, skin rubella is scratched where it itches, the diseases such as measles without adequate eruption, also effective to carbuncle, cellulitis, scabies, tinea, dermatitis rhus in addition.Herba Menthae contains menthol, and this material can fresh breath have the multiple property of medicine, can alleviate stomachache, gallbladder problem as spasm, also have antisepsis and sterilization, diuresis, reduces phlegm, stomach invigorating and the effect such as aid digestion.A large amount of edible Herba Menthae can cause insomnia, but low dose of eating conduces to sleep.

Caulis Spatholobi: chicken sedan-chair rattan bitter but slightly sweet taste, warm in nature, returns liver, the heart, kidney channel; Caulis Spatholobi red complexion enters blood, and matter profit row is loose; There is relaxing muscles and tendons to promote blood circulation, effect of nourishing blood for regulating menstruation; Cure mainly rheumatic arthralgia, numb hand and foot, quadriplegia, menoxenia, blockage of menstruation, dysmenorrhea, amenorrhea, leukopenia.The waist gonalgia, rheumatic arthralgia, the numb limbs and tense tendons for the treatment of caused by rheumatism, the compatibilities such as normal and Flos Carthami Semen Persicae, Radix Paeoniae Rubra, Pheretima, the Radix Astragali, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae.Can be used for menoxenia, amenorrhea, dysmenorrhea.

Radix Polygalae: the function of have Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.

Semen Sinapis Albae: reduce phlegm by drink; Mass dissipating and swelling eliminating.Main cough with asthma abundant expectoration; Fullness in the chest and hypochondriac pain; Numb limbs and tense tendons; Arthralgia; Multiple abscess caused by damp-phlegm; Carbuncle of yin nature toxic swelling.Control acute mastitis, breast carcinoma, mammary gland pain, tuberculosis, phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, regurgitation is vomitted, aphasia due to apoplexy, and limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.

Flos Rosae Rugosae: Flos Rosae Rugosae, turbid clearly and not, and and not violent, easing the affected liver is waken up stomach, and thin gas is invigorated blood circulation, and a surname is logical stops up stagnant and absolutely not pungent temperature is just dry fraud, breaking pushes away among edema caused by disorder of QI medicine, have most prompt effect and the most tractable, fragrant all product, there is no equal, the flower opened at the beginning of Flos Rosae Rugosae and root can be used as medicine, regulate the flow of vital energy, invigorate blood circulation, Thyme Extract, cure mainly menoxenia, traumatic injury, irritability are had a stomachache, the diseases such as newborn too fat to move pain.

Folium Acanthopanacis Radicis: acrid in the mouth; Property is put down, and function cures mainly: loose wind dehumidifying; Promoting blood circulation and stopping pain; Heat-clearing and toxic substances removing.Main skin rheumatism; Treating swelling and pain by traumatic injury; Colic; Erysipelas.

Bulbus Lilii: sweet; Micro-hardship; Be slightly cold, Lilium Germplasm Herb returns through the heart; Lung meridian, function cures mainly: nourishing YIN and moistening the lung; Clearing away heart-fire for tranquillization.Main deficiency of YIN chronic cough; Sputum mixed with blood; The calentura later stage; Waste heat is clear, or the unsuccessful caused fidgets due to deficiency palpitation with fear of feelings will, insomnia and dreamful sleep, absentminded; Carbuncle; Eczema.

Folium Artemisiae Argyi: pungent, bitter, temperature.Gui Jing returns liver,spleen,kidney warp.Effect warming the meridian for stopping bleeding, dispersing cold for relieving pain; External removing dampness to relieve itching.

Cure mainly for spitting blood, epistaxis, metrorrhagia, menorrhagia, vaginal bleeding during pregnancy hematochezia, few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile; External treatment skin pruritus.Vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding is hemorrhage for deficient cold type.

Herba Apocyni veneti: root of Apocynum venetum L. decoct has cardiotonic.Folium Apocyni Veneti extractum has calmness, anticonvulsant action, and has stronger diuresis, reduction blood fat, immunity moderation, defying age and suppress the effects such as influenza virus, has certain adjuvant treatment effect to hyperpietic.Nature and flavor: property of medicine sweet, bitter, cold.Return Liver Channel.Suppressing liver-YANG, clearing away heat and promoting diuresis.Can treat and have a dizzy spell and edema, dysuria.

Radix Lagerstroemia indica L.: Radix Lagerstroemia indica L. is the root of Lythraceae plant Lagerstroemia indica L., has effect of promoting the circulation of blood, controls carbuncle sore tumefacting virus, toothache, dysentery.

Fructus Piperis Longi: pungent, heat.Gui Jing returns stomach, large intestine channel.Effect warming spleen and stomach for dispelling cold, therapeutic method to keep the adverse QI flowing downwards pain relieving.Cure mainly for coldness and pain in the epigastrium, vomiting, has loose bowels, QI stagnated by cold, obstruction of qi in the chest and cardialgia, headache, toothache.

Flos Chrysanthemi Indici: the leaf of Herba Dendranthematis indici, flower and all herbal medicine.Bitter in the mouth, pungent, cool, heat-clearing and toxic substances removing, wind-dispelling heat-dissipating, dissipating blood stasis, improving eyesight, blood pressure lowering.Prevent and treat epidemic cerebrospinal meningitis, prevention influenza, flu, treatment hypertension, hepatitis, dysentery, carbuncle furuncle treatment skin ulcer have positive effect.The immersion of Flos Chrysanthemi Indici is to killing wriggler and fly larvae is also very effective.

Arisaema Cum Bile: clearing away fire and eliminating phlegm, relieving convulsion fixed chronic.Control middle wind-phlegm fan, infantile convulsion epilepsy, phlegm-fire is breathed heavily and is coughed, phlegm-accumulating vertigo.1. " book on Chinese herbal medicine just ": control acute infantile convulsion, Jiao is closed in real expectorant excess-fire heap soil or fertilizer over and around the roots, and asthma is irritated, terribly thirsty distension.2. " book on Chinese herbal medicine converges and says ": control infantile convulsion and shy expectorant, tic of the limbs, adult's deficiency of vital energy interior-heat, the raw expectorant of heat stagnation.3. " medicineization justice ": cure mainly all apoplexy, acute infantile convulsion, infantile convulsion, wind syndrome of head, dizzy, old god is slow-witted, and children's sends out and jerks, puerperal severe palpitation.

Chinese medicine preparation of the present invention debates the principle of disease control based on Chinese medicine, treat more comprehensive, lasting medicine, external volatile oil, spreads upon the position of headache, and 3 circles are respectively rubbed in left and right, in addition oral formulations is being taken, take into account inside and outside belonging to, the migraine prescription for the treatment of both the principal and secondary aspects of a disease, has fabulous therapeutical effect to migraine.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

embodiment 1one treats migrainous Chinese medicine preparation, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Radix Bupleuri 3 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Herba Menthae 1 part, Caulis Spatholobi 2 parts, Radix Polygalae 1 part, Semen Sinapis Albae 3 parts, Flos Rosae Rugosae 4 parts, Folium Acanthopanacis Radicis 2 parts, Bulbus Lilii 5 parts, Folium Artemisiae Argyi 5 parts, Herba Apocyni veneti 3 parts, Radix Lagerstroemia indica L. 1 part, Fructus Piperis Longi 6 parts, Flos Chrysanthemi Indici 3 parts, Arisaema Cum Bile 10 parts.

One treats migrainous Chinese medicine preparation, and preparation process is as follows:

1. Flos Chrysanthemi Indici is first used the clean water one time of room temperature, put into clean container, with the hot water of 80 DEG C, be dipped to the complete variable color of water, filter, filtrate is stand-by, the Rhizoma Atractylodis Macrocephalae, Herba Menthae and Folium Artemisiae Argyi are cleaned, is pounded disintegrating slag, be placed in gained filtrate, soak 40 minutes, soaked raw material is placed in boiler, and add water in pot the dipped bed of material, and the bottom of a pan is heated, water boils post-heating 10 minutes, is separated upper strata fluid and namely obtains external volatile oil;

2. Radix Bupleuri, Caulis Spatholobi, Radix Polygalae, Semen Sinapis Albae, Folium Acanthopanacis Radicis, Herba Apocyni veneti, Radix Lagerstroemia indica L., Fructus Piperis Longi and Arisaema Cum Bile are placed in marmite, add the clear water of raw material weight 3 times, first soak 20 minutes, be fried open turning intense fire, intense fire puts into Flos Rosae Rugosae after boiling 2 minutes and Bulbus Lilii is making slow fire boiling into 10 minutes, filter, filtering residue is stand-by;

3. by step 2. gained filtering residue, again add the hot water of raw material weight 2 times, decoct and stir 20 minutes, filter, obtain filtrate for subsequent use;

4. by step 2. with step 3. gained filtrate mix, cross 180 order drainage screens, mixing filtrate be heated to 50 DEG C, put into the Mel of filtrate weight 0.2 times, after Mel melts completely, cool bottling and namely obtain oral formulations.

model case one:liu XX, man, 50 years old, Jinan City, Shandong Province personage, has had on the right side of recurrent exerbation and has had a headache the time of 1 year, has a surplus because operating pressure larger right side headache increases the weight of half a year, in recent year, headache is on average shown effect 1-2 time weekly, and each lasting 4 hours, if it is bad to have a rest, severe headache during outbreak, companion's Nausea and vomiting, without speech, limb function and disturbance of consciousness, oral rotundine, Ergotamine heterodyne.Health check-up: blood pressure 130/80mmhg, cranial nerve is normal, and neck is soft, greasy in tongue, rolling pulse.Electroencephalogram is normal, head CT and magnetic resonance examination without exception.Diagnosis: migraine.In this time in 1 year, patient says the doctor seen many times, eats much famous and precious medicine, but effect is not fine, and doctor advised takes Chinese medicine preparation of the present invention.

Take the embodiment of the present invention 1 gained Chinese medicine composition and with the use of embodiment 1 gained volatile oil, after 5 days, patient's sensation pain when falling ill is so inviolent, the symptoms such as Nausea and vomiting are not had yet, continue to take add use after 15 days after, basic malaise symptoms disappears, the state of an illness is basicly stable, continues to take to do 1 course for the treatment of and consolidates, without recurrence after drug withdrawal.

embodiment 2one treats migrainous Chinese medicine preparation, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Radix Bupleuri 9 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Herba Menthae 5 parts, Caulis Spatholobi 6 parts, Radix Polygalae 3 parts, Semen Sinapis Albae 7 parts, Flos Rosae Rugosae 6 parts, Folium Acanthopanacis Radicis 4 parts, Bulbus Lilii 15 parts, Folium Artemisiae Argyi 9 parts, Herba Apocyni veneti 6 parts, Radix Lagerstroemia indica L. 3 parts, Fructus Piperis Longi 10 parts, Flos Chrysanthemi Indici 8 parts, Arisaema Cum Bile 15 parts.

One treats migrainous Chinese medicine preparation, and preparation process is as follows:

1. Flos Chrysanthemi Indici is first used the clean water one time of room temperature, put into clean container, with the hot water of 100 DEG C, be dipped to the complete variable color of water, filter, filtrate is stand-by, the Rhizoma Atractylodis Macrocephalae, Herba Menthae and Folium Artemisiae Argyi are cleaned, is pounded disintegrating slag, be placed in gained filtrate, soak 60 minutes, soaked raw material is placed in boiler, and add water in pot the dipped bed of material, and the bottom of a pan is heated, water boils post-heating 20 minutes, is separated upper strata fluid and namely obtains external volatile oil;

2. Radix Bupleuri, Caulis Spatholobi, Radix Polygalae, Semen Sinapis Albae, Folium Acanthopanacis Radicis, Herba Apocyni veneti, Radix Lagerstroemia indica L., Fructus Piperis Longi and Arisaema Cum Bile are placed in marmite, add the clear water of raw material weight 6 times, first soak 40 minutes, be fried open turning intense fire, intense fire puts into Flos Rosae Rugosae after boiling 6 minutes and Bulbus Lilii is making slow fire boiling into 30 minutes, filter, filtering residue is stand-by;

3. by step 2. gained filtering residue, again add the hot water of raw material weight 4 times, decoct and stir 40 minutes, filter, obtain filtrate for subsequent use;

4. by step 2. with step 3. gained filtrate mix, cross 220 order drainage screens, mixing filtrate be heated to 50 DEG C, put into the Mel of filtrate weight 0.6 times, after Mel melts completely, cool bottling and namely obtain oral formulations.

embodiment 3one treats migrainous Chinese medicine preparation, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Radix Bupleuri 5 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Herba Menthae 2 parts, Caulis Spatholobi 3 parts, Radix Polygalae 1.5 parts, Semen Sinapis Albae 4 parts, Flos Rosae Rugosae 4.5 parts, Folium Acanthopanacis Radicis 2.5 parts, Bulbus Lilii 8 parts, Folium Artemisiae Argyi 6 parts, Herba Apocyni veneti 4 parts, Radix Lagerstroemia indica L. 1.5 parts, Fructus Piperis Longi 7 parts, Flos Chrysanthemi Indici 4 parts, Arisaema Cum Bile 11 parts.

One treats migrainous Chinese medicine preparation, and preparation process is as follows:

1. Flos Chrysanthemi Indici is first used the clean water one time of room temperature, put into clean container, with the hot water of 85 DEG C, be dipped to the complete variable color of water, filter, filtrate is stand-by, the Rhizoma Atractylodis Macrocephalae, Herba Menthae and Folium Artemisiae Argyi are cleaned, is pounded disintegrating slag, be placed in gained filtrate, soak 45 minutes, soaked raw material is placed in boiler, and add water in pot the dipped bed of material, and the bottom of a pan is heated, water boils post-heating 13 minutes, is separated upper strata fluid and namely obtains external volatile oil;

2. Radix Bupleuri, Caulis Spatholobi, Radix Polygalae, Semen Sinapis Albae, Folium Acanthopanacis Radicis, Herba Apocyni veneti, Radix Lagerstroemia indica L., Fructus Piperis Longi and Arisaema Cum Bile are placed in marmite, add the clear water of raw material weight 4 times, first soak 25 minutes, be fried open turning intense fire, intense fire puts into Flos Rosae Rugosae after boiling 3 minutes and Bulbus Lilii is making slow fire boiling into 15 minutes, filter, filtering residue is stand-by;

3. by step 2. gained filtering residue, again add the hot water of raw material weight 2.5 times, decoct and stir 25 minutes, filter, obtain filtrate for subsequent use;

4. by step 2. with step 3. gained filtrate mix, cross 190 order drainage screens, mixing filtrate be heated to 50 DEG C, put into the Mel of filtrate weight 0.3 times, after Mel melts completely, cool bottling and namely obtain oral formulations.

embodiment 4one treats migrainous Chinese medicine preparation, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Radix Bupleuri 7 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Herba Menthae 4 parts, Caulis Spatholobi 5 parts, Radix Polygalae 2.5 parts, Semen Sinapis Albae 6 parts, Flos Rosae Rugosae 5.5 parts, Folium Acanthopanacis Radicis 3.5 parts, Bulbus Lilii 13 parts, Folium Artemisiae Argyi 8 parts, Herba Apocyni veneti 5 parts, Radix Lagerstroemia indica L. 2.5 parts, Fructus Piperis Longi 9 parts, Flos Chrysanthemi Indici 7 parts, Arisaema Cum Bile 14 parts.

One treats migrainous Chinese medicine preparation, and preparation process is as follows:

1. Flos Chrysanthemi Indici is first used the clean water one time of room temperature, put into clean container, with the hot water of 95 DEG C, be dipped to the complete variable color of water, filter, filtrate is stand-by, the Rhizoma Atractylodis Macrocephalae, Herba Menthae and Folium Artemisiae Argyi are cleaned, is pounded disintegrating slag, be placed in gained filtrate, soak 55 minutes, soaked raw material is placed in boiler, and add water in pot the dipped bed of material, and the bottom of a pan is heated, water boils post-heating 18 minutes, is separated upper strata fluid and namely obtains external volatile oil;

2. Radix Bupleuri, Caulis Spatholobi, Radix Polygalae, Semen Sinapis Albae, Folium Acanthopanacis Radicis, Herba Apocyni veneti, Radix Lagerstroemia indica L., Fructus Piperis Longi and Arisaema Cum Bile are placed in marmite, add the clear water of raw material weight 5 times, first soak 35 minutes, be fried open turning intense fire, intense fire puts into Flos Rosae Rugosae after boiling 5 minutes and Bulbus Lilii is making slow fire boiling into 25 minutes, filter, filtering residue is stand-by;

3. by step 2. gained filtering residue, again add the hot water of raw material weight 3.5 times, decoct and stir 35 minutes, filter, obtain filtrate for subsequent use;

4. by step 2. with step 3. gained filtrate mix, cross 210 order drainage screens, mixing filtrate be heated to 50 DEG C, put into the Mel of filtrate weight 0.5 times, after Mel melts completely, cool bottling and namely obtain oral formulations.

model case two:military xx, man, 55 years old, people from Jiyang County, Jinan City, Shandong Province.Workman, because of overworked sudden headache, with singultus uncomfortable in chest, insomnia such as to be insomnia at the symptom, and the dark violet spottiness of body of the tongue or ecchymosis, stringy and hesitant pulse, goes examination in hospital to be diagnosed as migraine.

Take the embodiment of the present invention 4 gained Chinese medicine composition and with the use of embodiment 4 gained volatile oil, after 7 days, patient's readme, the pain relief of all timing outbreak former every day, after continuing again to take 10 days, malaise symptoms disappears substantially.

embodiment 5one treats migrainous Chinese medicine preparation, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Radix Bupleuri 6 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Herba Menthae 3 parts, Caulis Spatholobi 4 parts, Radix Polygalae 2 parts, Semen Sinapis Albae 5 parts, Flos Rosae Rugosae 5 parts, Folium Acanthopanacis Radicis 3 parts, Bulbus Lilii 10 parts, Folium Artemisiae Argyi 7 parts, Herba Apocyni veneti 4.5 parts, Radix Lagerstroemia indica L. 2 parts, Fructus Piperis Longi 8 parts, Flos Chrysanthemi Indici 5.5 parts, Arisaema Cum Bile 12.5 parts.

One treats migrainous Chinese medicine preparation, and preparation process is as follows:

1. Flos Chrysanthemi Indici is first used the clean water one time of room temperature, put into clean container, with the hot water of 90 DEG C, be dipped to the complete variable color of water, filter, filtrate is stand-by, the Rhizoma Atractylodis Macrocephalae, Herba Menthae and Folium Artemisiae Argyi are cleaned, is pounded disintegrating slag, be placed in gained filtrate, soak 50 minutes, soaked raw material is placed in boiler, and add water in pot the dipped bed of material, and the bottom of a pan is heated, water boils post-heating 15 minutes, is separated upper strata fluid and namely obtains external volatile oil;

2. Radix Bupleuri, Caulis Spatholobi, Radix Polygalae, Semen Sinapis Albae, Folium Acanthopanacis Radicis, Herba Apocyni veneti, Radix Lagerstroemia indica L., Fructus Piperis Longi and Arisaema Cum Bile are placed in marmite, add the clear water of raw material weight 4.5 times, first soak 30 minutes, be fried open turning intense fire, intense fire puts into Flos Rosae Rugosae after boiling 4 minutes and Bulbus Lilii is making slow fire boiling into 20 minutes, filter, filtering residue is stand-by;

3. by step 2. gained filtering residue, again add the hot water of raw material weight 3 times, decoct and stir 30 minutes, filter, obtain filtrate for subsequent use;

4. by step 2. with step 3. gained filtrate mix, cross 200 order drainage screens, mixing filtrate be heated to 50 DEG C, put into the Mel of filtrate weight 0.4 times, after Mel melts completely, cool bottling and namely obtain oral formulations.

experimental example:clinical data: (1) physical data: carry out clinical observation treatment to 400 routine patients, wherein male 200 example, women 200 example, at 16 to 60 years old ages, is equally divided into two groups, is the migraine that a variety of causes causes.

(2) Therapeutic Method: gained external volatile oil, spreads upon the position of headache, and 3 circles are respectively rubbed in left and right, is taking oral formulations in addition, oral formulations of the present invention 3 times on the one, each 10ml 7 days is a course for the treatment of.

(3) efficacy assessment standard:

Cure: migrainous Clinical symptom and sign disappears, functional activity recovers normal.

Effective: migraine clinical symptoms is clearly better or substantially disappears.

Effective: migraine clinical symptoms is improved, but unstable, has recurrence after drug withdrawal.

Invalid: Clinical symptom and sign is without improvement.

(4) therapeutic effect: experimental group: clinical cure 190 example, accounts for 95%; Effective 4 examples, account for 2%; Effective 6 examples, account for 3%; Invalid 0 example; Total effective rate 100%.

Matched group: clinical cure 140 example, accounts for 70%; Effective 10 examples, account for 5%; Effective 10 examples, account for 5%; Invalid 40 examples; Total effective rate 80%.

Prove through clinical trial, take Chinese medicine preparation of the present invention compared with the migrainous means of other treatment, control recurrence rate after healing low, means of prevention is more comprehensive thoroughly, have no side effect during taking, prove through clinical trial, Chinese drugs agentia effective percentage of the present invention is 100%, has good preventive and therapeutic effect to migraine.

Claims (10)

1. treat a migrainous Chinese medicine preparation, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Radix Bupleuri 3-9 part, Rhizoma Atractylodis Macrocephalae 5-9 part, Herba Menthae 1-5 part, Caulis Spatholobi 2-6 part, Radix Polygalae 1-3 part, Semen Sinapis Albae 3-7 part, Flos Rosae Rugosae 4-6 part, Folium Acanthopanacis Radicis 2-4 part, Bulbus Lilii 5-15 part, Folium Artemisiae Argyi 5-9 part, Herba Apocyni veneti 3-6 part, Radix Lagerstroemia indica L. 1-3 part, Fructus Piperis Longi 6-10 part, Flos Chrysanthemi Indici 3-8 part, Arisaema Cum Bile 10-15 part.

2. the migrainous Chinese medicine preparation for the treatment of according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Radix Bupleuri 5-7 part, Rhizoma Atractylodis Macrocephalae 6-8 part, Herba Menthae 2-4 part, Caulis Spatholobi 3-5 part, Radix Polygalae 1.5-2.5 part, Semen Sinapis Albae 4-6 part, Flos Rosae Rugosae 4.5-5.5 part, Folium Acanthopanacis Radicis 2.5-3.5 part, Bulbus Lilii 8-13 part, Folium Artemisiae Argyi 6-8 part, Herba Apocyni veneti 4-5 part, Radix Lagerstroemia indica L. 1.5-2.5 part, Fructus Piperis Longi 7-9 part, Flos Chrysanthemi Indici 4-7 part, Arisaema Cum Bile 11-14 part.

3. the migrainous Chinese medicine preparation for the treatment of according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Radix Bupleuri 6 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Herba Menthae 3 parts, Caulis Spatholobi 4 parts, Radix Polygalae 2 parts, Semen Sinapis Albae 5 parts, Flos Rosae Rugosae 5 parts, Folium Acanthopanacis Radicis 3 parts, Bulbus Lilii 10 parts, Folium Artemisiae Argyi 7 parts, Herba Apocyni veneti 4.5 parts, Radix Lagerstroemia indica L. 2 parts, Fructus Piperis Longi 8 parts, Flos Chrysanthemi Indici 5.5 parts, Arisaema Cum Bile 12.5 parts.

4. the preparation method of the migrainous Chinese medicine preparation of the treatment according to any one of claim 1-3, is characterized in that: step is as follows:

1. Flos Chrysanthemi Indici is first used the clean water one time of room temperature, put into clean container, with the hot water of 80-100 DEG C, be dipped to the complete variable color of water, filter, filtrate is stand-by, the Rhizoma Atractylodis Macrocephalae, Herba Menthae and Folium Artemisiae Argyi are cleaned, is pounded disintegrating slag, be placed in gained filtrate, soak 40-60 minute, soaked raw material is placed in boiler, and add water in pot the dipped bed of material, and the bottom of a pan is heated, water boils post-heating 10-20 minute (preferably 15 minutes), is separated upper strata fluid and namely obtains external volatile oil;

2. Radix Bupleuri, Caulis Spatholobi, Radix Polygalae, Semen Sinapis Albae, Folium Acanthopanacis Radicis, Herba Apocyni veneti, Radix Lagerstroemia indica L., Fructus Piperis Longi and Arisaema Cum Bile are placed in marmite, add raw material weight 3-6 clear water doubly, first soak 20-40 minute, be fried open turning intense fire, intense fire puts into Flos Rosae Rugosae after boiling 2-6 minute and Bulbus Lilii is making slow fire boiling 10-30 minute into, filter, filtering residue is stand-by;

3. by step 2. gained filtering residue, again add raw material weight 2-4 hot water doubly, decoct and stir 20-40 minute, filter, obtain filtrate for subsequent use;

4. by step 2. with step 3. gained filtrate mix, cross 180-220 order drainage screen, mixing filtrate is heated to 50 DEG C, puts into filtrate weight 0.2-0.6 Mel doubly, after Mel melts completely, cools bottling and namely obtain oral formulations.

5. the preparation method of Chinese medicine preparation according to claim 4, is characterized in that: 1. step uses the hot water of 85-95 DEG C, is dipped to the complete variable color of water (preferred, with the hot water of 90 DEG C, to be dipped to the complete variable color of water).

6. the preparation method of Chinese medicine preparation according to claim 4, is characterized in that: 1. step soaks 45-55 minute, soaked raw material is placed in boiler (preferred, to soak 50 minutes, soaked raw material is placed in boiler).

7. the preparation method of Chinese medicine preparation according to claim 4, is characterized in that: 2. step adds raw material weight 4-5 clear water doubly, first soaks 25-35 minute (preferred, to add the clear water of raw material weight 4.5 times, first soak 30 minutes).

8. the preparation method of Chinese medicine preparation according to claim 4, it is characterized in that: step 2. intense fire is put into Flos Rosae Rugosae and Bulbus Lilii and made into slow fire boiling 15-25 minute (preferred, intense fire puts into Flos Rosae Rugosae after boiling 4 minutes and Bulbus Lilii is making slow fire boiling into 20 minutes) after boiling 3-5 minute.

9. the preparation method of Chinese medicine preparation according to claim 4, it is characterized in that: 3. step adds raw material weight 2.5-3.5 hot water doubly again, decoct while stir 25-35 minute (preferred, again to add the hot water of raw material weight 3 times, decoct and stir 30 minutes).

10. the preparation method of Chinese medicine preparation according to claim 4, it is characterized in that: 4. step crosses 190-210 order drainage screen, mixing filtrate is heated to 50 DEG C, put into filtrate weight 0.3-0.5 Mel doubly (preferred, cross 200 order drainage screens, mixing filtrate is heated to 50 DEG C, puts into the Mel of filtrate weight 0.4 times).