CN100444892C - Baoning pinellia tuber granules for relieving cough and sputum, and regulating stomach and stopping vomitting, and its production method - Google Patents

Abstract

The present invention discloses a Chinese medicine Baoning Banxia granule preparation with the functions of relieving cough and reducing sputum, preventing asthma, regulating the function of the stomach and preventing or arresting vomiting, disintegrating masses and removing obstruction and relieving pain for effectively curing cough due to pathogenic wind-cold, fullness in the chest and hypochondrium and chronic cough, etc, with obvious therapeutic effect. Said granule preparation is made up by using 12 Chinese medicinal materials of pinellia tuber, katsumada's galangal seed, amomum fruit, cinnamon bark, saussurea root, clove and others through a certain preparation process.

Description

Peaceful pinellia tuber granules of the guarantor of a kind of relieving cough and resolving phlegm, stomach function regulating preventing or arresting vomiting and production method thereof

Technical field

The present invention relates to the pharmaceutical composition of a kind of relieving cough and resolving phlegm, stomach function regulating preventing or arresting vomiting, especially relate to

And a kind of be the relieving cough and resolving phlegm that forms of feedstock production, the peaceful pinellia tuber granules of guarantor and the production method thereof of stomach function regulating preventing or arresting vomiting with the Chinese herbal medicine, belong to the field of Chinese medicines.

Background technology

As everyone knows, China is in industrialization at present, in the modernization process, air pollution is comparatively serious, because the pollution of air and the factor of Changes in weather, people's upper respiratory tract sickness rate increases year by year, and China is World tobacco production big country, and smoker's quantity reaches more than 300,000,000 people, and long-term smoking also can cause the disease of upper respiratory tract, though the Chinese patent medicine of the relieving cough and resolving phlegm of Xiao Shouing is many on the market, as fritillary-loquat liquid, shake bile-fritillary oral liquid, JIZHI TANGJIANG etc., but the viewpoint of Chinese medicine is thought: " being that medicine just has three fens poison ", though these Chinese patent medicines have certain curative effect, the intestines and stomach, the especially stomach to people has certain side effect simultaneously.

Summary of the invention

The objective of the invention is to provides the peaceful pinellia tuber granules of guarantor of a kind of relieving cough and resolving phlegm, stomach function regulating preventing or arresting vomiting for overcoming the deficiencies in the prior art.

The peaceful pinellia tuber granules of guarantor of the present invention is mainly made by following bulk drugs:

1000 parts of Fructus Amomi Rotunduss of Rhizoma Pinelliae Preparata (shelling) 1-20 part

Fructus Amomi (shelling) 1-20 part Cortex Cinnamomi 1-20 part

Radix Aucklandiae 5-30 part Flos Caryophylli 1-20 part

Fructus Aurantii Immaturus 1-20 part Fructus Aurantii 1-20 part

Fructus Schisandrae Chinensis 1-20 part Pericarpium Citri Reticulatae 1-20 part

Rhizoma Zingiberis Recens 1-20 part Radix Glycyrrhizae 20-80 part

Be preferably:

1000 parts of Fructus Amomi Rotunduss of Rhizoma Pinelliae Preparata (shelling) 3-15 part

Fructus Amomi (shelling) 3-15 part Cortex Cinnamomi 3-15 part

Radix Aucklandiae 5-20 part Flos Caryophylli 3-15 part

Fructus Aurantii Immaturus 5-15 part Fructus Aurantii 5-15 part

Fructus Schisandrae Chinensis 5-15 part Pericarpium Citri Reticulatae 3-12 part

Rhizoma Zingiberis Recens 3-10 part Radix Glycyrrhizae 30-50 part

Can add sucrose 200-500 part and make correctives.

The peaceful pinellia tuber granules of guarantor of the present invention is coughed, is panted based on Chinese medicine and takes into account the dialectical principle that combines of stomach function regulating preventing or arresting vomiting, and treating both the principal and secondary aspects of a disease according to the theory of Chinese medical science prescription, is prepared from according to certain weight proportion natural plant.

Monarch drug in the Rhizoma Pinelliae side of being has drying dampness to eliminate phlegm, dissolving lump and resolving mass, the effect of stopping nausea and vomiting by lowering the adverse flow of QI.Its property and flavor of peppery and warm is gone into the taste warp, and the power of reducing phlegm is good, for controlling various phlegm syndrome key medicines.The spleen being the source of producing phlegm, the device of stomach for being received.Phlegm-damp is loved spleen, Rhizoma Pinelliae energy drying dampness to eliminate phlegm; Disorder of stomach-QI, the Rhizoma Pinelliae also can regulating the stomach and sending down the abnormal ascending QI.The Rhizoma Pinelliae reduces phlegm, based on not removing dampness of spleen, poly-and be the expectorant person; It is warm in nature and dry, and particularly belonging to trembles with fear has wet person must use in institute.Rhizoma Pinelliae preventing or arresting vomiting is based on obstruction of phlegm and QI, the contrary discord of stomach; But because of it has good stopping nausea and vomiting by lowering the adverse flow of QI effect, so except that being applicable to vomiting due to fluid-retention, still can be used for the insufficiency of stomach vomiting.The Rhizoma Pinelliae is given birth to poisonous, and clinical use is many based on Rhizoma Pinelliae Preparata.

The hot temperature of Fructus Amomi Rotundus and not hot, fragrance and gas is clear is gone into lung meridian a surname the chest stuffiness relieving that stagnates, and goes into taste removing dampness circulation of qi promoting, and warming middle-JIAO and can preventing or arresting vomiting is the key medicine of the middle upper and middle portions of the body cavity cold-damp stagnation of QI.Fructus Amomi and Fructus Amomi Rotundus, nature and flavor are identical, all go into taste, have all that removing dampness is amusing, the promoting the circulation of QI to alleviate the stagnation in middle-JIAO effect.The two share and is ministerial drug.

Cortex Cinnamomi warming middle-JIAO YANG invigorating, dispersing cold for relieving pain; Radix Aucklandiae promoting the circulation of QI to relieve pain; The Flos Caryophylli warming middle-JIAO to send down the adverse QI, warming the kidney to activate YANG.Three flavor medicines share, warming spleen and stomach for dispelling cold, and all pains of separating cold coagulation, the edema caused by disorder of QI retardance of unclogging and readjusting gastrointestinal is adjuvant drug altogether.

The Fructus Aurantii Immaturus circulation of qi promoting removes distension, the numbness of reducing phlegm out, consumer product dredge stasis.Its bitter in the mouth and being slightly cold is gone into spleen, stomach, large intestine channel, and it is big that hardship is let out power, and circulation of qi promoting power is strong, so be the medicine of dispelling the stagnated QI, the property sedimentation is and descending, and function is regulated the flow of vital energy except that painful abdominal mass, to remove breast abdomen feeling of fullness, double can reducing phlegm to open numbness, removing food stagnancy is high a dose of dispelling the stagnated QI knot with intestinal stasis relieving in fact, controls feeling of fullness, leads stagnant key medicine.Fructus Aurantii Immaturus and Fructus Aurantii are all fruit, distinguish because of old children is different.Both effects are omited together, but the strong Fructus Aurantii power of Fructus Aurantii Immaturus power is slow.Fructus Aurantii is similar to Fructus Aurantii Immaturus, but the thin property of power is slow, removes based on promoting the circulation of QI to alleviate the stagnation in middle-JIAO and expands, and is applicable to distending pain in the chest and hypochondrium, gastral cavity abdomen painful abdominal mass is vexed is main.The two share and is adjuvant drug.Fructus Aurantii Immaturus is given birth to effect more violent, so clinical how being used as medicine with Fructus Aurantii Immaturus (parched).

The Fructus Schisandrae Chinensis nourishing kidney of astringing the lung, the arresting sweating that promotes the production of body fluid, arresting seminal emission antidiarrheal.Fructus Schisandrae Chinensis can on the gas of astringing the lung, following nourishing kidney-yin, the chronic cough dyspnea due to deficiency due to lung kidney two lost can be received the effect of relieving cough and asthma, is adjuvant drug.

Pericarpium Citri Reticulatae is gone into spleen lung two warps, and property is gentle and mainly rise floatingly, is longer than that reason spleen lung qi stagnates, drying dampness to eliminate phlegm, and can spleen invigorating, is adjuvant drug.

Rhizoma Zingiberis Recens acrid in the mouth warm in nature is longer than and is dispersed, again can warming middle-JIAO and preventing or arresting vomiting is used for diseases such as affection of exogenous wind-cold and cold in the stomach drink more, be messenger drug.

The Radix Glycyrrhizae invigorating the spleen and replenishing QI, eliminating fire and detoxication, lung moistening is eliminated the phlegm, and relaxes the property of medicine, the emergency analgesic therapy.Sweet slow lung moistening has the effect of expelling phlegm for arresting cough, pants and waits disease with controlling cough clinically, and normal and the application of preventing phlegm from forming and stopping coughing medicine compatibility are as the product of assisting.Because of its character is gentle, so no matter lung cold cough with asthma or cough due to lung-heat, but equal fit applications.In addition, Radix Glycyrrhizae can also relax the property of medicine, has to lower or the strong effect of mitigation medicine.

Medicine of the present invention is to the cough due to wind and cold, and pertinacious phlegm is not changed, and old cough etc. has good therapeutic effect, sees clinical experiment report:

Drug therapy of the present invention is coughed curative effect relatively in various degree

	The example number	Recovery from illness	Produce effects	Effectively	Invalid	Effective percentage
							Slightly	150	123	20	7		100％
Moderate	150	100	36	14		100％
							Severe	150	90	45	15		100％

Drug therapy pertinacious phlegm of the present invention not chemotherapy is imitated relatively

The example number	Recovery from illness	Produce effects	Effectively	Invalid	Effective percentage
						150	96	33	21		100％

The old cough of Drug therapy of the present invention curative effect relatively

The example number	Recovery from illness	Produce effects	Effectively	Invalid	Effective percentage
						150	125	14	11		100％

From pharmaceutical formulation of the present invention and therapeutic effect as can be seen, since the prescription in all medicines share reached relieving cough and resolving phlegm, the sending down the abnormal ascending QI of relievining asthma, the function of stomach function regulating preventing or arresting vomiting, dissolving lump and resolving mass, effectively treat the cough due to wind and cold, it is out of breath to pant, damp-phlegm cold drink, chest distress, chronic cough is not healed, and pertinacious phlegm is not changed and disease such as old cough.Reached relieving cough and resolving phlegm fully, the goal of the invention of stomach function regulating preventing or arresting vomiting.

Another object of the present invention provides a kind of production method of protecting peaceful pinellia tuber granules.

Produce the method for protecting peaceful pinellia tuber granules, step is as follows:

1) take by weighing each raw material by following weight portion proportioning:

1000 parts of Rhizoma Pinelliae Preparata, Fructus Amomi Rotundus (shelling) 1-20 part, Fructus Amomi (shelling) 1-20 part, Cortex Cinnamomi 1-20 part, Radix Aucklandiae 5-30 part, Flos Caryophylli 1-20 part, Fructus Aurantii Immaturus 1-20 part, Fructus Aurantii 1-20 part, Fructus Schisandrae Chinensis 1-20 part, Pericarpium Citri Reticulatae 1-20 part, Rhizoma Zingiberis Recens 1-20 part, Radix Glycyrrhizae 20-80 part;

2) Rhizoma Pinelliae Preparata is crushed to the 100-150 order, sieving for standby through cleaning;

3) the crude drug powder is made: Fructus Amomi, and Fructus Amomi Rotundus, Cortex Cinnamomi, the Radix Aucklandiae, Flos Caryophylli is removed impurity through cleaning, and with 30 ℃～100 ℃ cold drying, pulverizes 100 mesh sieves, and it is standby in the clean container to pack into steam (100 ℃～150 ℃) sterilization;

4) all the other medicines are dropped in the extraction pot after clean, concocting, solution is that water body soaks, and soak time is 10-30 minute, through extracting, concentrates again, is concentrated into relative density 1.05～1.10 extractum (60 ℃ of hot surveys);

5) getting sucrose, to be crushed to 100 orders with the self cooling dust-free pulverizing mill of turbine standby;

6) with Rhizoma Pinelliae powder, the crude drug powder, cane sugar powder sprays into extractum with the mixer mixing, granulates, drying, granulate sieves, and particle diameter 0.32-0.88mm packs with aluminium plastic bag after the assay was approved, warehouse-in.

The specific embodiment

Embodiment 1: the peaceful pinellia tuber granules of guarantor of the present invention is mainly made by following bulk drugs:

1 part in 1000 parts of Fructus Amomi Rotunduss of Rhizoma Pinelliae Preparata (shelling)

1 part of 1 portion of Cortex Cinnamomi of Fructus Amomi (shelling)

1 part of 5 portions of Flos Caryophylli of the Radix Aucklandiae

1 part of 1 part of Fructus Aurantii of Fructus Aurantii Immaturus

1 part of 1 part of Pericarpium Citri Reticulatae of Fructus Schisandrae Chinensis

20 parts in 1 portion of Radix Glycyrrhizae of Rhizoma Zingiberis Recens

Produce as follows and protect peaceful pinellia tuber granules:

1) Rhizoma Pinelliae Preparata is crushed to 100 orders, sieving for standby through cleaning;

2) the crude drug powder is made: Fructus Amomi, and Fructus Amomi Rotundus, Cortex Cinnamomi, the Radix Aucklandiae, Flos Caryophylli is removed impurity through cleaning, and with 30 ℃ of cold drying, pulverizes 100 mesh sieves, and it is standby in the clean container to pack into steam (100 ℃) sterilization;

3) all the other medicines are dropped in the extraction pot after clean, concocting, solution is that water body soaks, and soak time is 10 minutes, through extracting, concentrates again, is concentrated into relative density 1.05 extractum (60 ℃ of hot surveys);

4) getting sucrose, to be crushed to 100 orders with the self cooling dust-free pulverizing mill of turbine standby;

5) with Rhizoma Pinelliae powder, the crude drug powder, cane sugar powder sprays into extractum with the mixer mixing, granulates, drying, granulate sieves, and particle diameter 0.32-0.88mm packs with aluminium plastic bag after the assay was approved, warehouse-in.

Embodiment 2: the peaceful pinellia tuber granules of guarantor of the present invention is mainly made by following bulk drugs:

20 parts in 1000 parts of Fructus Amomi Rotunduss of Rhizoma Pinelliae Preparata (shelling)

20 parts of 20 portions of Cortex Cinnamomis of Fructus Amomi (shelling)

20 parts of 30 portions of Flos Caryophyllis of the Radix Aucklandiae

20 parts of 20 parts of Fructus Aurantiis of Fructus Aurantii Immaturus

20 parts of 20 parts of Pericarpium Citri Reticulataes of Fructus Schisandrae Chinensis

80 parts in 20 portions of Radix Glycyrrhizaes of Rhizoma Zingiberis Recens

Produce as follows and protect peaceful pinellia tuber granules:

1) Rhizoma Pinelliae Preparata is crushed to 100 orders, sieving for standby through cleaning;

2) the crude drug powder is made: Fructus Amomi, and Fructus Amomi Rotundus, Cortex Cinnamomi, the Radix Aucklandiae, Flos Caryophylli is removed impurity through cleaning, and with 100 ℃ of cold drying, pulverizes 100 mesh sieves, and it is standby in the clean container to pack into steam (150 ℃) sterilization;

3) all the other medicines are dropped in the extraction pot after clean, concocting, solution is that water body soaks, and soak time is 30 minutes, through extracting, concentrates again, is concentrated into relative density 1.10 extractum (60 ℃ of hot surveys);

4) getting sucrose, to be crushed to 100 orders with the self cooling dust-free pulverizing mill of turbine standby;

5) with Rhizoma Pinelliae powder, the crude drug powder, cane sugar powder sprays into extractum with the mixer mixing, granulates, drying, granulate sieves, and particle diameter 0.32-0.88mm packs with aluminium plastic bag after the assay was approved, warehouse-in.

Embodiment 3: the peaceful pinellia tuber granules of guarantor of the present invention is mainly made by following bulk drugs:

10 parts in 1000 parts of Fructus Amomi Rotunduss of Rhizoma Pinelliae Preparata (shelling)

10 parts of 10 portions of Cortex Cinnamomis of Fructus Amomi (shelling)

10 parts of 15 portions of Flos Caryophyllis of the Radix Aucklandiae

10 parts of 10 parts of Fructus Aurantiis of Fructus Aurantii Immaturus

10 parts of 10 parts of Pericarpium Citri Reticulataes of Fructus Schisandrae Chinensis

50 parts in 10 portions of Radix Glycyrrhizaes of Rhizoma Zingiberis Recens

Production method is with embodiment 1.

Claims (4)

1, the peaceful pinellia tuber granules of guarantor of a kind of relieving cough and resolving phlegm, stomach function regulating preventing or arresting vomiting is characterized in that: made by following bulk drugs:

1000 parts of Semen Myristicae (shell removed) 1-20 of Rhizoma Pinelliae Preparata part

Fructus Amomi 1-20 part Cortex Cinnamomi 1-20 part of shelling

Radix Aucklandiae 5-30 part Flos Caryophylli 1-20 part

Fructus Aurantii Immaturus 1-20 part Fructus Aurantii 1-20 part

Fructus Schisandrae Chinensis 1-20 part Pericarpium Citri Reticulatae 1-20 part

Rhizoma Zingiberis Recens 1-20 part Radix Glycyrrhizae 20-80 part

2, the peaceful pinellia tuber granules of guarantor of relieving cough and resolving phlegm according to claim 1, stomach function regulating preventing or arresting vomiting is characterized in that: made by following bulk drugs:

1000 parts of Semen Myristicae (shell removed) 3-15 of Rhizoma Pinelliae Preparata part

Fructus Amomi 3-15 part Cortex Cinnamomi 3-15 part of shelling

Radix Aucklandiae 10-20 part Flos Caryophylli 5-15 part

Fructus Aurantii Immaturus 5-15 part Fructus Aurantii 5-15 part

Fructus Schisandrae Chinensis 5-15 part Pericarpium Citri Reticulatae 3-12 part

Rhizoma Zingiberis Recens 3-10 part Radix Glycyrrhizae 30-50 part

3, the peaceful pinellia tuber granules of guarantor of relieving cough and resolving phlegm according to claim 1, stomach function regulating preventing or arresting vomiting is characterized in that: make correctives with sucrose 200-500 part.

4, the production method of the peaceful pinellia tuber granules of guarantor of the described relieving cough and resolving phlegm of a kind of claim 1, stomach function regulating preventing or arresting vomiting, it is characterized in that: the step of production method is as follows:

1) take by weighing each raw material by following weight portion proportioning:

1000 parts of Rhizoma Pinelliae Preparata, Semen Myristicae (shell removed) 1-20 part, the Fructus Amomi 1-20 part of shelling, Cortex Cinnamomi 1-20 part, Radix Aucklandiae 5-30 part, Flos Caryophylli 1-20 part, Fructus Aurantii Immaturus 1-20 part, Fructus Aurantii 1-20 part, Fructus Schisandrae Chinensis 1-20 part, Pericarpium Citri Reticulatae 1-20 part, Rhizoma Zingiberis Recens 1-20 part, Radix Glycyrrhizae 20-80 part;

2) Rhizoma Pinelliae Preparata is crushed to the 100-150 order, sieving for standby through cleaning;

3) the crude drug powder is made: Fructus Amomi, and Fructus Amomi Rotundus, Cortex Cinnamomi, the Radix Aucklandiae, Flos Caryophylli is removed impurity through cleaning, and with 30 ℃～100 ℃ cold drying, pulverizes 100 mesh sieves, and it is standby in the clean container to pack into 100 ℃～150 ℃ steam sterilizations;

4) all the other medicines are dropped in the extraction pot after clean, concocting, solution is that water body soaks, and soak time is 10-30 minute, through extracting, concentrates again, and the relative density when being concentrated into 60 ℃ of hot surveys is 1.05～1.10 extractum;

5) getting sucrose, to be crushed to 100 orders with the self cooling dust-free pulverizing mill of turbine standby;

6) with Rhizoma Pinelliae powder, the crude drug powder, cane sugar powder sprays into extractum with the mixer mixing, granulates, drying, granulate sieves, and particle diameter 0.32-0.88mm packs with aluminium plastic bag after the assay was approved, warehouse-in.