CN101167871A - Compound pearl lozenge and preparation method and application thereof - Google Patents
Compound pearl lozenge and preparation method and application thereof Download PDFInfo
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- CN101167871A CN101167871A CNA2007101663736A CN200710166373A CN101167871A CN 101167871 A CN101167871 A CN 101167871A CN A2007101663736 A CNA2007101663736 A CN A2007101663736A CN 200710166373 A CN200710166373 A CN 200710166373A CN 101167871 A CN101167871 A CN 101167871A
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Abstract
The invention discloses a compound pearl buccal tablet and process for preparation and the application of the invention. The invention comprises active components and / or additiver which is acceptable in pharmacy, and the active components comprise pearl powder 150 to 400 grams, natrii sulfas exsiccatus 50 to 100 grams, borneol 10 to 30 grams, borax 50 to 200 grams, radix rehmanniae 50 to 200 grams, glycyrrhiza 50 to 100 grams, menthol 1 to 4 grams, lactose 100 to 200 grams, citric acid 15 to 35 grams, aspartame 20 to 40 grams, and fragrant citrus essence 80 to 200 grams, which are made into 1000 tablets. The invention has distinct functions of bacteriostasis and anti-inflammatory, expelling phlegm, analgesia, and accelerating the removal of the rot-ten tissueaction, which has distinct inhibitory effects to oral inflammation and concomitant symptoms of the oral inflammation. The invention is suitable for preventing and curing acute and chronic pharyngolaryngitis, acute and chronic tonsillitis, vocal fold submucous bleeding, vocal nodules, periodontal diseases, and ulcerative stomatitis and the like.
Description
One, invention field
The present invention relates to a kind of pharmaceutical composition for the treatment of oral disease and preparation method thereof, more particularly relate to a kind of compound pearl lozenge and its production and application.
Two, background technology
Acute and chronic pharyngitis is common clinical, frequently-occurring disease.Buccal tablet can directly act on the bottleneck throat of inflammation, makes the part can keep higher drug level, is characterized in acting on strong, rapid-action.Buccal tablet is of a great variety, and the Western medicine buccal tablet is to be principal agent with disinfectant and surfactant mostly, thereby curative effect is general, and still has some particular restriction when using.In recent years, the research and development of Chinese medicine buccal tablet is rapid, and large quantities of Chinese medicine buccal tablet has been applied to clinically, but curative effect is uneven.
Three, goal of the invention
One of purpose of the present invention provides a kind of compound pearl lozenge for the treatment of oral disease.
Two of purpose of the present invention provides a kind of preparation method for the treatment of the compound pearl lozenge of oral disease.
This and other purpose of the present invention will further embody and set forth by following detailed description and explanation.
Compound pearl lozenge of the present invention, form by active component and/or pharmaceutically acceptable additives that following raw materials according makes:
Margarita powder 150-400 gram Matrii Sulfas Exsiccatus 50-100 gram
Borneolum Syntheticum 10-30 gram Borax 50-200 gram
Radix Rehmanniae 50-200 gram Radix Glycyrrhizae 50-100 gram
Mentholum 1-4 gram lactose 100-200 gram
The sweet 20-40 gram of citric acid 15-35 Ke Asiba
The smart 80-200 of fragrant citrus restrains into 1000.
Further, compound pearl lozenge of the present invention, form by active component and/or pharmaceutically acceptable additives that following raw materials according makes:
Margarita powder 200-300 gram Matrii Sulfas Exsiccatus 60-80 gram
Borneolum Syntheticum 15-25 gram Borax 80-150 gram
Radix Rehmanniae 80-150 gram Radix Glycyrrhizae 70-100 gram
Mentholum 1-3 gram lactose 100-150 gram
The sweet 20-30 gram of citric acid 20-30 Ke Asiba
The smart 80-120 of fragrant citrus restrains into 1000.
What can select is, compound pearl lozenge of the present invention is made up of active component and/or pharmaceutically acceptable additives that following raw materials according makes:
Margarita powder 220-250 gram Matrii Sulfas Exsiccatus 70-80 gram
Borneolum Syntheticum 15-20 gram Borax 90-120 gram
Radix Rehmanniae 90-120 gram Radix Glycyrrhizae 70-80 gram
Mentholum 1-2 gram lactose 130-150 gram
The sweet 25-30 gram of citric acid 25-30 Ke Asiba
The smart 90-110 of fragrant citrus restrains into 1000.
In compound pearl lozenge of the present invention, described Margarita powder is a nanoscale, and particle size range is the 1-100 nanometer.
The preparation method of compound pearl lozenge of the present invention is to get the Radix Glycyrrhizae and the Radix Rehmanniae of formula ratio, adds 10-30 times of water gaging, decocts 1-3 time, each 2-4 hour, merge decoction liquor, leave standstill filtration, being concentrated into relative relative density is that 1.20-1.25 becomes extractum, spray drying, pulverize then, during adding Margarita powder, lactose, citric acid and A Siba are sweet, mix homogeneously, make granule, dry again; Other gets Matrii Sulfas Exsiccatus, Borneolum Syntheticum, Borax, Mentholum and the fragrant citrus essence of formula ratio, and mixing adds in the above-mentioned granule, and mixing adds an amount of magnesium stearate at last and makes 1000 once more, packing.
Be preferably, the preparation method of compound pearl lozenge of the present invention is to get the Radix Glycyrrhizae and the Radix Rehmanniae of formula ratio, adds 20-30 times of water gaging, decoct 1-3 time, each 2.5-3 hour, merge decoction liquor, leave standstill filtration, being concentrated into relative relative density is that 1.20-1.25 becomes extractum, and spray drying is pulverized then, during adding Margarita powder, lactose, citric acid and A Siba are sweet, mix homogeneously is made granule, and is dry again; Other gets Matrii Sulfas Exsiccatus, Borneolum Syntheticum, Borax, Mentholum and the fragrant citrus essence of formula ratio, and mixing adds in the above-mentioned granule, and mixing adds an amount of magnesium stearate at last and makes 1000 once more, packing.
What can select is that the preparation method of compound pearl lozenge of the present invention is to get the Radix Glycyrrhizae and the Radix Rehmanniae of formula ratio, adds 24 times of water gagings, decoct 2 times, each 3 hours, merge decoction liquor, leave standstill filtration, being concentrated into relative relative density is that 1.20-1.25 becomes extractum, and spray drying is pulverized then, during adding Margarita powder, lactose, citric acid and A Siba are sweet, mix homogeneously is made granule, and is dry again; Other gets Matrii Sulfas Exsiccatus, Borneolum Syntheticum, Borax, Mentholum and the fragrant citrus essence of formula ratio, and mixing adds in the above-mentioned granule, and mixing adds an amount of magnesium stearate at last and makes 1000 once more, packing.
Compound pearl lozenge of the present invention is to be primary raw material with the nanometer Margarita powder, compatible with other 6 flavor Chinese medicine such as Matrii Sulfas Exsiccatus, Borax, Borneolum Syntheticum, Mentholum, Radix Rehmanniae, Radix Glycyrrhizae, have heat-clearing and toxic substances removing, detumescence and apocenosis, YIN nourishing and the production of body fluid promoting, pharynx-clearing throat-benefiting, lung moistening promoting the circulation of QI, expelling pus and promoting granulation, analgesic hemostatic effect.Adopt nanometer pearl powder,, improve curative effect, show through clinical observation and pharmaceutical research to strengthen it in the oral cavity and the absorption of throat, can be used for preventing and treating acute and chronic pharyngolaryngitis, acute and chronic tonsillitis, submucosa hemorrhage of vocal cords, vocal nodule, periodontal, oral ulcer etc.Curative effect is safe and reliable, and the relevant report that has no adverse reaction has significant advantage in the like product of market.
Compound pearl lozenge of the present invention has tangible antibacterial anti-inflammatory, eliminates the phlegm, pain relieving and removing the necrotic tissue and promoting granulation effect, and oral inflammation and simultaneous phenomenon thereof are had remarkable inhibitory action.Show to have following effect through clinical observation and pharmaceutical research, comprising:
1, to staphylococcus aureus, escherichia coli, bacillus pyocyaneus, Hemolytic streptococcus, oral cavity and throat diseases susceptible pathogenic microorganisms such as Candida albicans all have significant inhibitory effect, and bacteriostasis is strong than JINSANGZI HOUPIAN and Waterelon Frost Lozenges.
2, the mice auricle swelling that Oleum Tiglii is caused all has inhibitory action.
3, the hyperfunction symptom of inflammation capillary permeability due to the xylol has inhibitory action.
4, can suppress the mouse peritoneal leukoplania that causes by sodium carboxymethyl cellulose.
5, on Carrageenan causes scorching rat paw edema all significant inhibitory effect, and suppressing the swelling effect can continue more than 4 hours.
6, can significantly reduce mice granuloma induced by implantation of cotton pellets coefficient, can be used for inflammation-inhibiting granulation tissue hyperplasia in late period.
7, can significantly promote the excretion that the mice trachea is phenol red, have the excretory effect of the sputum of promotion.
8, the pain that causes of Dichlorodiphenyl Acetate has significant inhibitory effect, and certain analgesic effect is arranged.
9, can improve the pain threshold of mice, certain analgesic activity is arranged, can be used for the pain symptom that amelioration of inflammation is followed.
10, can promote phenol to cause the healing of rat experiment oral ulcer, tangible removing the necrotic tissue and promoting granulation effect is arranged.
The all raw material of Shi Yonging etc. all is conventional uses in the present invention, can buy from market.In the present invention, refer in particular to as non-, all amount, percentage ratios are unit of weight.
Below in conjunction with embodiment the present invention is carried out concrete description.As known by the technical knowledge, the present invention can realize by other the embodiment that does not break away from its spirit or essential feature.Therefore, following embodiment with regard to each side, all just illustrates, and is not only.All within the scope of the present invention or the change that is equal in the scope of the present invention all be included in the invention.
Four, the specific embodiment
Embodiment 1
Take by weighing raw material by following proportioning:
Nanometer Margarita powder 230 gram Matrii Sulfas Exsiccatus 80 gram Borneolum Syntheticums 18 grams
Borax 110 gram Radix Rehmanniae 100 gram Radix Glycyrrhizaes 80 grams
Mentholum 2 gram lactose 130 gram citric acids 25 grams
The sweet 25 gram fragrant citrus essences 90 of A Siba are restrained into 1000.
Preparation by the following method:
Get the Radix Glycyrrhizae and the Radix Rehmanniae of formula ratio, add 24 times of water gagings, decoct 2 times, each 3 hours, merge decoction liquor, leave standstill filtration, being concentrated into relative relative density is that 1.20-1.25 becomes extractum, spray drying, pulverize then, during adding Margarita powder, lactose, citric acid and A Siba are sweet, mix homogeneously, make granule, dry again; Other gets Matrii Sulfas Exsiccatus, Borneolum Syntheticum, Borax, Mentholum and the fragrant citrus essence of formula ratio, and mixing adds in the above-mentioned granule, and mixing adds an amount of magnesium stearate at last and makes 1000 once more, packing.
Embodiment 2
Take by weighing raw material by following proportioning:
Margarita powder (1-100 nanometer) 350 gram Matrii Sulfas Exsiccatus 80 gram Borneolum Syntheticums 28 grams
Borax 180 gram Radix Rehmanniae 50 gram Radix Glycyrrhizaes 50 grams
Mentholum 1 gram lactose 100 gram citric acids 35 grams
The sweet 35 gram fragrant citrus essences 100 of A Siba are restrained into 1000.
Preparation by the following method:
Get the Radix Glycyrrhizae and the Radix Rehmanniae of formula ratio, add 30 times of water gagings, decoct 3 times, each 2-4 hour, merge decoction liquor, leave standstill filtration, being concentrated into relative relative density is that 1.20-1.25 becomes extractum, spray drying, pulverize then, during adding Margarita powder, lactose, citric acid and A Siba are sweet, mix homogeneously, make granule, dry again; Other gets Matrii Sulfas Exsiccatus, Borneolum Syntheticum, Borax, Mentholum and the fragrant citrus essence of formula ratio, and mixing adds in the above-mentioned granule, and mixing adds an amount of magnesium stearate at last and makes 1000 once more, packing.
Embodiment 3
Take by weighing raw material by following proportioning:
Nanometer Margarita powder 150 gram Matrii Sulfas Exsiccatus 50 gram Borneolum Syntheticums 10 grams
Borax 60 gram Radix Rehmanniae 180 gram Radix Glycyrrhizaes 100 grams
Mentholum 3.5 gram lactose 180 gram citric acids 30 grams
The sweet 35 gram fragrant citrus essences 180 of A Siba are restrained into 1000.
Preparation by the following method:
Get the Radix Glycyrrhizae and the Radix Rehmanniae of formula ratio, add 15 times of water gagings, decoct 2 times, each 2-3 hour, merge decoction liquor, leave standstill filtration, being concentrated into relative relative density is that 1.20-1.25 becomes extractum, spray drying, pulverize then, during adding Margarita powder, lactose, citric acid and A Siba are sweet, mix homogeneously, make granule, dry again; Other gets Matrii Sulfas Exsiccatus, Borneolum Syntheticum, Borax, Mentholum and the fragrant citrus essence of formula ratio, and mixing adds in the above-mentioned granule, and mixing adds an amount of magnesium stearate at last and makes 1000 once more, packing.
Embodiment 4
Take by weighing raw material by following proportioning:
Nanometer Margarita powder 240 gram Matrii Sulfas Exsiccatus 80 gram Borneolum Syntheticums 20 grams
Borax 110 gram Radix Rehmanniae 100 gram Radix Glycyrrhizaes 100 grams
Mentholum 2 gram lactose 130 gram citric acids 25 grams
The sweet 25 gram fragrant citrus essences 90 of A Siba are restrained into 1000.
Preparation by the following method:
Get the Radix Glycyrrhizae and the Radix Rehmanniae of formula ratio, add 24 times of water gagings, decoct 2 times, each 3 hours, merge decoction liquor, leave standstill filtration, being concentrated into relative relative density is that 1.20-1.25 becomes extractum, spray drying, pulverize then, during adding Margarita powder, lactose, citric acid and A Siba are sweet, mix homogeneously, make granule, dry again; Other gets Matrii Sulfas Exsiccatus, Borneolum Syntheticum, Borax, Mentholum and the fragrant citrus essence of formula ratio, and mixing adds in the above-mentioned granule, and mixing adds an amount of magnesium stearate at last and makes 1000 once more, and packing promptly gets product of the present invention.
Claims (8)
1. compound pearl lozenge is characterized in that the active component and/or the pharmaceutically acceptable additives that are made by following raw materials according form:
Margarita powder 150-400 gram Matrii Sulfas Exsiccatus 50-100 gram
Borneolum Syntheticum 10-30 gram Borax 50-200 gram
Radix Rehmanniae 50-200 gram Radix Glycyrrhizae 50-100 gram
Mentholum 1-4 gram lactose 100-200 gram
The sweet 20-40 gram of citric acid 15-35 Ke Asiba
The smart 80-200 of fragrant citrus restrains into 1000.
2. compound pearl lozenge according to claim 1 is characterized in that the active component and/or the pharmaceutically acceptable additives that are made by following raw materials according form:
Margarita powder 200-300 gram Matrii Sulfas Exsiccatus 60-80 gram
Borneolum Syntheticum 15-25 gram Borax 80-150 gram
Radix Rehmanniae 80-150 gram Radix Glycyrrhizae 70-100 gram
Mentholum 1-3 gram lactose 100-150 gram
The sweet 20-30 gram of citric acid 20-30 Ke Asiba
The smart 80-120 of fragrant citrus restrains into 1000.
3. compound pearl lozenge according to claim 1 is characterized in that the active component and/or the pharmaceutically acceptable additives that are made by following raw materials according form:
Margarita powder 220-250 gram Matrii Sulfas Exsiccatus 70-80 gram
Borneolum Syntheticum 15-20 gram Borax 90-120 gram
Radix Rehmanniae 90-120 gram Radix Glycyrrhizae 70-80 gram
Mentholum 1-2 gram lactose 130-150 gram
The sweet 25-30 gram of citric acid 25-30 Ke Asiba
The smart 90-110 of fragrant citrus restrains into 1000.
4. according to the described compound pearl lozenge of one of claim 1-3, it is characterized in that described Margarita powder is a nanoscale, particle size range is the 1-100 nanometer.
5. according to the preparation method of one of claim 1-3 described compound pearl lozenge, it is characterized in that getting the Radix Glycyrrhizae and the Radix Rehmanniae of formula ratio, add 10-30 times of water gaging, decoct 1-3 time, each 2-4 hour, merge decoction liquor, leave standstill filtration, being concentrated into relative relative density is that 1.20-1.25 becomes extractum, and spray drying is pulverized then, during adding Margarita powder, lactose, citric acid and A Siba are sweet, mix homogeneously is made granule, and is dry again; Other gets Matrii Sulfas Exsiccatus, Borneolum Syntheticum, Borax, Mentholum and the fragrant citrus essence of formula ratio, and mixing adds in the above-mentioned granule, and mixing adds an amount of magnesium stearate at last and makes 1000 once more, packing.
6. according to the preparation method of one of claim 1-3 described compound pearl lozenge, it is characterized in that getting the Radix Glycyrrhizae and the Radix Rehmanniae of formula ratio, add 20-30 times of water gaging, decoct 1-3 time, each 2.5-3 hour, merge decoction liquor, leave standstill filtration, being concentrated into relative relative density is that 1.20-1.25 becomes extractum, and spray drying is pulverized then, during adding Margarita powder, lactose, citric acid and A Siba are sweet, mix homogeneously is made granule, and is dry again; Other gets Matrii Sulfas Exsiccatus, Borneolum Syntheticum, Borax, Mentholum and the fragrant citrus essence of formula ratio, and mixing adds in the above-mentioned granule, and mixing adds an amount of magnesium stearate at last and makes 1000 once more, packing.
7. according to the preparation method of one of claim 1-3 described compound pearl lozenge, it is characterized in that getting the Radix Glycyrrhizae and the Radix Rehmanniae of formula ratio, add 24 times of water gagings, decoct 2 times, each 3 hours, merge decoction liquor, leave standstill filtration, being concentrated into relative relative density is that 1.20-1.25 becomes extractum, and spray drying is pulverized then, during adding Margarita powder, lactose, citric acid and A Siba are sweet, mix homogeneously is made granule, and is dry again; Other gets Matrii Sulfas Exsiccatus, Borneolum Syntheticum, Borax, Mentholum and the fragrant citrus essence of formula ratio, and mixing adds in the above-mentioned granule, and mixing adds an amount of magnesium stearate at last and makes 1000 once more, packing.
8. according to the application of one of claim 1-3 described compound pearl lozenge, it is characterized in that having tangible antibacterial anti-inflammatory, eliminate the phlegm, pain relieving and removing the necrotic tissue and promoting granulation effect, oral inflammation and simultaneous phenomenon thereof there are remarkable inhibitory action.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101663736A CN101167871B (en) | 2007-11-08 | 2007-11-08 | Compound pearl lozenge and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101663736A CN101167871B (en) | 2007-11-08 | 2007-11-08 | Compound pearl lozenge and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
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| CN101167871A true CN101167871A (en) | 2008-04-30 |
| CN101167871B CN101167871B (en) | 2010-11-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2007101663736A Expired - Fee Related CN101167871B (en) | 2007-11-08 | 2007-11-08 | Compound pearl lozenge and preparation method and application thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102961587A (en) * | 2012-12-13 | 2013-03-13 | 山东宏济堂制药集团有限公司 | Medicine for treating pharyngitis type chronic inflammation and preparation method thereof |
| CN103446333A (en) * | 2013-08-01 | 2013-12-18 | 孙海德 | Medicament for preventing and treating odontia |
| CN104258092A (en) * | 2014-10-24 | 2015-01-07 | 王志敏 | Gargle for treating recurrent aphthous ulcer and periodontitis and preparation method thereof |
| CN105495595A (en) * | 2015-12-23 | 2016-04-20 | 太仓东浔生物科技有限公司 | Pearl containing buccal tablets and preparation method |
| CN107802678A (en) * | 2017-12-04 | 2018-03-16 | 黑龙江参鸽药业有限公司 | A kind of scattered preparation method of larynx health |
| CN108324772A (en) * | 2018-04-27 | 2018-07-27 | 江西中医药大学 | Treat the Chinese medicine composition and preparation method thereof of mouth disease |
| CN108904539A (en) * | 2018-07-23 | 2018-11-30 | 广东永青生物科技有限公司 | Application of the pearl fructose composite in preparation prevention and treatment mouth ulcer lozenge |
-
2007
- 2007-11-08 CN CN2007101663736A patent/CN101167871B/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102961587A (en) * | 2012-12-13 | 2013-03-13 | 山东宏济堂制药集团有限公司 | Medicine for treating pharyngitis type chronic inflammation and preparation method thereof |
| CN103446333A (en) * | 2013-08-01 | 2013-12-18 | 孙海德 | Medicament for preventing and treating odontia |
| CN104258092A (en) * | 2014-10-24 | 2015-01-07 | 王志敏 | Gargle for treating recurrent aphthous ulcer and periodontitis and preparation method thereof |
| CN104258092B (en) * | 2014-10-24 | 2017-10-20 | 王志敏 | A kind of gargle for treating RAU and periodontosis and preparation method thereof |
| CN105495595A (en) * | 2015-12-23 | 2016-04-20 | 太仓东浔生物科技有限公司 | Pearl containing buccal tablets and preparation method |
| CN107802678A (en) * | 2017-12-04 | 2018-03-16 | 黑龙江参鸽药业有限公司 | A kind of scattered preparation method of larynx health |
| CN107802678B (en) * | 2017-12-04 | 2021-05-07 | 黑龙江参鸽药业有限公司 | Preparation method of throat-health powder |
| CN108324772A (en) * | 2018-04-27 | 2018-07-27 | 江西中医药大学 | Treat the Chinese medicine composition and preparation method thereof of mouth disease |
| CN108904539A (en) * | 2018-07-23 | 2018-11-30 | 广东永青生物科技有限公司 | Application of the pearl fructose composite in preparation prevention and treatment mouth ulcer lozenge |
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| Publication number | Publication date |
|---|---|
| CN101167871B (en) | 2010-11-03 |
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Address after: 311800 Zhejiang Province, Zhuji city Jiyang street street, Sha Sha Road No. 48 Patentee after: Zhejiang changshengniao health Polytron Technologies Inc Address before: The beauty of Zhejiang province Zhuji city street 311800 No. 80 5 floor Patentee before: Zhejiang Changshengniao Pearl Biotechnology Co., Ltd. |
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Granted publication date: 20101103 Termination date: 20171108 |