CN103006803A - Preparation method of detoxicating tablet of cow-bezoar - Google Patents
Preparation method of detoxicating tablet of cow-bezoar Download PDFInfo
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- CN103006803A CN103006803A CN201210482404XA CN201210482404A CN103006803A CN 103006803 A CN103006803 A CN 103006803A CN 201210482404X A CN201210482404X A CN 201210482404XA CN 201210482404 A CN201210482404 A CN 201210482404A CN 103006803 A CN103006803 A CN 103006803A
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Abstract
The invention discloses a preparation method of a detoxicating tablet of cow-bezoar, and belongs to the technical field of Chinese medicament preparation. The method is reasonable in process flow setting, can be used for remarkably improving the production efficiency of the detoxicating tablet of cow-bezoar and reducing the heated time of realgar in the granulating process by adopting a one-step granulation method. The granulation efficiency is remarkably improved by increasing the density of extracted concentrate and spray liquid, so that the production efficiency of the detoxicating tablet of cow-bezoar is greatly improved, and the drying time in the granulating step is effectively reduced. According to the preparation method, the heated temperature of realgar and realgar-containing component in the drying process can be reduced, and the transformation amount of realgar to arsenic trioxide is effectively avoided, so that the production of toxic substances can be reduced, and the prepared product is safer and more reliable. The prepared product is high in effective component content and stable in quality by regulating the time of adding scutellaria baicalensis and decocting platycodon grandiflorum, liquorice, gyp and scutellaria baicalensis twice, and is in accordance with national standard.
Description
Technical field
The present invention relates to a kind of preparation method of detoxicating tablet of cow-bezoar, be specifically related to a kind of preparation method of detoxicating tablet of cow-bezoar, belong to the Chinese patent medicine preparing technical field.
Background technology
Detoxicating tablet of cow-bezoar is to change medicament development by the cow-bezoar anti-toxic bolus of enjoying eight one-hundred-year history famous medicines to form; be the heat-clearing and toxic substances removing recipe; cure mainly burning hot interior the Sheng; laryngopharynx swelling and pain, gingival swelling and pain, aphtha of the mouth and tongue; conjunctival congestion and swelling pain etc.; determined curative effect is clinical commonly used drug still now, is a lot of families standing " gunpowder of dispelling ".Yet the report of relevant detoxicating tablet of cow-bezoar initiation safety issue is of common occurrence in recent years, just pays close attention to the safety issue of detoxicating tablet of cow-bezoar since State Food and Drug Administration's medicine assessment centers adverse drug reaction monitoring place at the end of the nineties in century.
" detoxicating tablet of cow-bezoar is made by Radix Et Rhizoma Rhei 200g, Radix Scutellariae 150g, Radix Platycodonis 100g, Radix Glycyrrhizae 50g, Gypsum Fibrosum 200g, artificial Calculus Bovis 5g, Borneolum Syntheticum 25g, Realgar 50g eight flavor Chinese medicines in the Chinese pharmacopoeia; wherein the toxicity of the seven flavor Chinese medicines such as Radix Et Rhizoma Rhei, Radix Scutellariae is lower, and only the strong toxicity of Realgar and consumption are large.The main component of Realgar is realgar, contains arsenic 75%, sulfur 24.9%, meets easily oxidation Decomposition of heat, generates hypertoxicity material arsenic trioxide, is commonly called as arsenicum.100 milligrams of arsenicum consumptions get final product the causing death, and a small amount of arsenicum can to the generation toxic action of the systems such as nerve, digestion, hemopoietic, urinary system, cause arseniasis.Arseniasis patient's performance is except having the symptoms such as headache, dizziness, also can cause gastrointestinal dysfunction, liver enlargement and numb limbs and tense tendons etc., there is the obvious obstacle of liver function in severe patient, but outstanding behaviours is skin lesion, cardinal symptom be cutaneous pigmentation, Keratoderma excessively, verrucous hyperplasia and skin carcinoma etc., wherein pigmentation is common with non-exposure portion such as trunk, buttocks and thighs, is raindrop shape or widely graniphyric black or sepia speckle.
Yet, on the detoxicating tablet of cow-bezoar operation instructions, seldom indicate adverse effect, also lack the safety issue caveat, even the unreceipted course for the treatment of, the only printed words of dated " anemia of pregnant woman's forbidding " in taboo.Although this medicine carries out control in China as prescription class medicine; but because the continuity of medication custom, detoxicating tablet of cow-bezoar still is the standing medicine among the some patients were man, many patients before taking this medicine without physician guidance; often arbitrarily increase consumption, prolong administration time, consequence is hardly imaginable.And Realgar mainly appears at the medicine preparation and stores link to the transformation of arsenicum, and therefore, the conversion of controlling these two link Raws is particularly important to the toxicity that reduces detoxicating tablet of cow-bezoar.
Chinese patent (publication number: CN 1733084A) disclose a kind of heat-clearing and detoxifying herb preparation and preparation method thereof; formed by the 8 flavor Chinese medicines such as above-mentioned Radix Et Rhizoma Rhei, Radix Scutellariae; purpose is for solving the shortcoming that antiphlogistic bezoar tablet disintegration time is long, bioavailability is low, but do not propose clear and definite solution with regard to the problem of toxicity and production efficiency.
Summary of the invention
The preparation method that the purpose of this invention is to provide a kind of detoxicating tablet of cow-bezoar.
In order to realize above purpose, the technical solution adopted in the present invention is:
(1) get sterilization, cross the Radix Et Rhizoma Rhei powder of 100～120 mesh sieves, and it is for subsequent use to cross respectively Borneolum Syntheticum powder and the bovine calculus powder of 60～100 mesh sieves;
(2) get Realgar, add water and grind to get 0.2～0.3kg/L serosity, getting the centrifugal postlyophilization of fine granularity serosity, to get Realgar powder for subsequent use;
(3) get Radix Platycodonis, Radix Glycyrrhizae, Gypsum Fibrosum, Radix Scutellariae, add 7～9 times of water gagings, decocted 1.5～2.5 hours, filter, filtering residue adds 5～7 times of amount warm water and decocted 1.5～2.5 hours again, filters, and it is concentrated that extractum is for subsequent use to merge twice decoction liquor;
(4) with step (1), (2) gained Radix Et Rhizoma Rhei powder and Realgar powder 45～60 ℃ of lower airpillow-dry 5～15 minutes, it is for subsequent use that mix homogeneously gets fecula;
(5) get dextrin, add water and stir post-heating to little 35～45% dextrin slurry that boils to get, it is for subsequent use that dextrin was starched 60～100 mesh sieves;
(6) with step (5) gained dextrin slurry in 1:(3～6) ratio adding step (3) gained extractum in, stir, spray to the fecula of step (4) after crossing 60～100 mesh sieves, 45～60 ℃ are dried to moisture is 2.0～3.0%, and granulate sieves;
(7) in step (6) gained granule, add Borneolum Syntheticum, the artificial Calculus Bovis of step (1), add again magnesium stearate, mixed 10～20 minutes with the rotating speed of 10～20r/min, again tabletting, sugar coating and get final product.
Reduce pressure with alcohol gas
Preferably, the joining day of described step (3) Radix Scutellariae is that stopped heating added Radix Scutellariae in 3～5 minutes after Radix Platycodonis, Radix Glycyrrhizae, Gypsum Fibrosum added water boil.It is to avoid effective ingredient baicalin chance cold water dissolution in the Radix Scutellariae that Radix Scutellariae stopped heating after liquid boils added one in 3～5 minutes, the 2nd, accidentally scald when avoiding operating.
Preferably, described step (3) filtrate to be concentrated into 77～83 ℃ of lower extractum relative densities be 1.19～1.21.More excellent, described step (6) with the dextrin slurry in 1:(3～4) ratio adding extractum in.Wherein, the concentrated solution relative density is larger, the bonding force of more gained of dextrin slurry addition extractum is stronger, and granulation efficient is higher.
Beneficial effect of the present invention:
Flow setting is reasonable among the preparation technology of detoxicating tablet of cow-bezoar of the present invention, adopts marumerization can not only significantly improve the production efficiency of detoxicating tablet of cow-bezoar, can also shorten the heated time of Realgar in pelletization.Significantly improve granulation efficient by increasing extraction concentrated solution and spray liquid density, thereby greatly improved the production efficiency of detoxicating tablet of cow-bezoar, simultaneously, also effectively reduced the drying time of granulation step.This law has effectively been avoided the turn amount of Realgar to arsenic trioxide, thereby has been reduced the growing amount of hypertoxicity material by reducing Realgar in the dry run and containing the heating temperature of Realgar component, makes the product that makes safer, reliable.By adjusting the joining day of Radix Scutellariae, and Radix Platycodonis, Radix Glycyrrhizae, Gypsum Fibrosum, Radix Scutellariae are carried out twice decoction, the active constituent content that makes product is high, and steady quality meets national standard.
The specific embodiment
Following embodiment only is described in further detail the present invention, but does not consist of any limitation of the invention.
Embodiment 1
(1) get sterilization, cross the Radix Et Rhizoma Rhei powder of 100 mesh sieves, and it is for subsequent use to cross respectively Borneolum Syntheticum powder and the bovine calculus powder of 80 mesh sieves;
(2) get Realgar, add water and grind to get the 0.2kg/L serosity, getting the centrifugal postlyophilization of fine granularity serosity, to get Realgar powder for subsequent use;
(3) get in Radix Platycodonis, Radix Glycyrrhizae, the Gypsum Fibrosum adding extraction pot, add 8 times of water gagings, stopped heating is 3～5 minutes after the heated and boiled, add Radix Scutellariae, decocted 2 hours, filter, filtering residue adds 6 times of amount warm water and decocted 2 hours again, filter, merge twice decoction liquor and place dual-effect energy-saving concentrator, it is that 1.19 extractum is for subsequent use that filtrate is concentrated into 77 ℃ of relative densities;
(4) step (1), (2) gained Radix Et Rhizoma Rhei powder and Realgar powder are placed the container of fluidized drying pelletizer, opening program is opened blower fan, and 50 ℃ of lower airpillow-dry 10 minutes, it is for subsequent use that mix homogeneously gets fecula;
(5) get dextrin, add water and stir post-heating to little 40% dextrin slurry that boils to get, it is for subsequent use that dextrin was starched 80 mesh sieves;
(6) ratio of step (5) gained dextrin slurry in 1:4 added in step (3) the gained extractum, stir, adopt one-step palletizing after crossing 80 mesh sieves, it is sprayed to the fecula of step (4) container, being dried to moisture in 45 ℃ again is 2.0%, and the granule granulate of packing in the vibrosieve is crossed the three-dimensional motion mixer of packing into behind 16 mesh sieves;
(7) in step (6) gained granule, add Borneolum Syntheticum, the artificial Calculus Bovis of step (1), add again magnesium stearate, seal, mix in the clean plastic bag of packing into after 15 minutes sealing with the rotating speed of 15r/min, again tabletting, sugar coating and get final product.
Embodiment 2
(1) get sterilization, cross the Radix Et Rhizoma Rhei powder of 120 mesh sieves, and it is for subsequent use to cross respectively Borneolum Syntheticum powder and the bovine calculus powder of 60 mesh sieves;
(2) get Realgar, add water and grind to get the 0.25kg/L serosity, getting the centrifugal postlyophilization of fine granularity serosity, to get Realgar powder for subsequent use;
(3) get in Radix Platycodonis, Radix Glycyrrhizae, the Gypsum Fibrosum adding extraction pot, add 7 times of water gagings, stopped heating is 3～5 minutes after the heated and boiled, add Radix Scutellariae, decocted 1.5 hours, filter, filtering residue adds 5 times of amount warm water and decocted 1.5 hours again, filter, merge twice decoction liquor and place dual-effect energy-saving concentrator, it is that 1.20 extractum is for subsequent use that filtrate is concentrated into 80 ℃ of relative densities;
(4) step (1), (2) gained Radix Et Rhizoma Rhei powder and Realgar powder are placed the container of fluidized drying pelletizer, opening program is opened blower fan, and 60 ℃ of lower airpillow-dry 5 minutes, it is for subsequent use that mix homogeneously gets fecula;
(5) get dextrin, add water and stir post-heating to little 35% dextrin slurry that boils to get, it is for subsequent use that dextrin was starched 60 mesh sieves;
(6) ratio of step (5) gained dextrin slurry in 1:3 added in step (3) the gained extractum, stir, adopt one-step palletizing after crossing 60 mesh sieves, it is sprayed to the fecula of step (4) container, being dried to moisture in 50 ℃ again is 2.5%, and the granule granulate of packing in the vibrosieve is crossed the three-dimensional motion mixer of packing into behind 16 mesh sieves;
(7) in step (6) gained granule, add Borneolum Syntheticum, the artificial Calculus Bovis of step (1), add again magnesium stearate, seal, mix in the clean plastic bag of packing into after 20 minutes sealing with the rotating speed of 10r/min, again tabletting, sugar coating and get final product.
Embodiment 3
(1) get sterilization, cross the Radix Et Rhizoma Rhei powder of 100 mesh sieves, and it is for subsequent use to cross respectively Borneolum Syntheticum powder and the bovine calculus powder of 100 mesh sieves;
(2) get Realgar, add water and grind to get the 0.3kg/L serosity, getting the centrifugal postlyophilization of fine granularity serosity, to get Realgar powder for subsequent use;
(3) get in Radix Platycodonis, Radix Glycyrrhizae, the Gypsum Fibrosum adding extraction pot, add 9 times of water gagings, stopped heating is 3～5 minutes after the heated and boiled, add Radix Scutellariae, decocted 2.5 hours, filter, filtering residue adds 7 times of amount warm water and decocted 2.5 hours again, filter, merge twice decoction liquor and place dual-effect energy-saving concentrator, it is that 1.21 extractum is for subsequent use that filtrate is concentrated into 83 ℃ of lower relative densities;
(4) step (1), (2) gained Radix Et Rhizoma Rhei powder and Realgar powder are placed the container of fluidized drying pelletizer, opening program is opened blower fan, and 45 ℃ of lower airpillow-dry 15 minutes, it is for subsequent use that mix homogeneously gets fecula;
(5) get dextrin, add water and stir post-heating to little 45% dextrin slurry that boils to get, it is for subsequent use that dextrin was starched 100 mesh sieves;
(6) ratio of step (5) gained dextrin slurry in 1:6 added in step (3) the gained extractum, stir, adopt one-step palletizing after crossing 100 mesh sieves, it is sprayed to the fecula of step (4) container, being dried to moisture in 60 ℃ again is 3.0%, and the granule granulate of packing in the vibrosieve is crossed the three-dimensional motion mixer of packing into behind 16 mesh sieves;
(7) in step (6) gained granule, add Borneolum Syntheticum, the artificial Calculus Bovis of step (1), add again magnesium stearate, seal, mix in the clean plastic bag of packing into after 10 minutes sealing with the rotating speed of 20r/min, again tabletting, sugar coating and get final product.
Test example
The embodiment of the invention 1～3 adopts marumerization, with conventional method of granulating production efficiency relatively see following table 1 for details.
The comparison of the method for granulating of table 1 embodiment 1～3 and conventional secondary granulation production efficiency
Claims (4)
1. the preparation method of a detoxicating tablet of cow-bezoar is characterized in that: may further comprise the steps:
(1) get sterilization, cross the Radix Et Rhizoma Rhei powder of 100～120 mesh sieves, and it is for subsequent use to cross respectively Borneolum Syntheticum powder and the bovine calculus powder of 60～100 mesh sieves;
(2) get Realgar, add water and grind to get 0.2～0.3kg/L serosity, getting the centrifugal postlyophilization of fine granularity serosity, to get Realgar powder for subsequent use;
(3) get Radix Platycodonis, Radix Glycyrrhizae, Gypsum Fibrosum, Radix Scutellariae, add 7～9 times of water gagings, decocted 1.5～2.5 hours, filter, filtering residue adds 5～7 times of amount warm water and decocted 1.5～2.5 hours again, filters, and it is concentrated that extractum is for subsequent use to merge twice decoction liquor;
(4) with step (1), (2) gained Radix Et Rhizoma Rhei powder and Realgar powder 45～60 ℃ of lower airpillow-dry 5～15 minutes, it is for subsequent use that mix homogeneously gets fecula;
(5) get dextrin, add water and stir post-heating to little 35～45% dextrin slurry that boils to get, it is for subsequent use that dextrin was starched 60～100 mesh sieves;
(6) with step (5) gained dextrin slurry in 1:(3～6) ratio adding step (3) gained extractum in, stir, spray to the fecula of step (4) after crossing 60～100 mesh sieves, 45～60 ℃ are dried to moisture is 2.0～3.0%, and granulate sieves;
(7) in step (6) gained granule, add Borneolum Syntheticum, the artificial Calculus Bovis of step (1), add again magnesium stearate, mixed 10～20 minutes with the rotating speed of 10～20r/min, again tabletting, sugar coating and get final product.
2. the preparation method of detoxicating tablet of cow-bezoar according to claim 1 is characterized in that: the joining day of described step (3) Radix Scutellariae is that stopped heating added Radix Scutellariae in 3～5 minutes after Radix Platycodonis, Radix Glycyrrhizae, Gypsum Fibrosum added water boil.
3. the preparation method of detoxicating tablet of cow-bezoar according to claim 1, it is characterized in that: it is 1.19～1.21 that described step (3) filtrate is concentrated into 77～83 ℃ of lower extractum relative densities.
4. the preparation method of detoxicating tablet of cow-bezoar according to claim 3 is characterized in that: described step (6) with the dextrin slurry in 1:(3～4) ratio adding extractum in.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104208175A (en) * | 2014-09-11 | 2014-12-17 | 江西九华药业有限公司 | Preparation method of cow-bezoar detoxicating tablet |
| CN106138254A (en) * | 2015-03-27 | 2016-11-23 | 索绪斌 | A kind of preparation method and applications of antiphlogistic bezoar buccal tablet |
| CN107648320A (en) * | 2017-06-26 | 2018-02-02 | 安徽永生堂药业有限责任公司 | A kind of detoxicating tablet of cow-bezoar and preparation method thereof |
| CN107802679A (en) * | 2017-12-13 | 2018-03-16 | 合肥凯石医药科技有限公司 | A kind of preparation method for the compound Chinese medicinal preparation for treating leukaemia |
| CN111920776A (en) * | 2020-08-03 | 2020-11-13 | 河北君临药业有限公司 | Preparation method of bezoar detoxicating tablet with definite curative effect |
| CN116370543A (en) * | 2023-04-20 | 2023-07-04 | 南京同仁堂药业有限责任公司 | Cattle yellow detoxification tablet and preparation method thereof |
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| CN1733084A (en) * | 2005-07-29 | 2006-02-15 | 王衡新 | Chinese medicinal preparation for clearing pathological heat and toxin and preparation process thereof |
| CN101991659A (en) * | 2009-08-11 | 2011-03-30 | 汤明昌 | Preparation with functions of clearing heat and releasing toxin and preparation method |
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2012
- 2012-11-23 CN CN201210482404.XA patent/CN103006803B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1733084A (en) * | 2005-07-29 | 2006-02-15 | 王衡新 | Chinese medicinal preparation for clearing pathological heat and toxin and preparation process thereof |
| CN101991659A (en) * | 2009-08-11 | 2011-03-30 | 汤明昌 | Preparation with functions of clearing heat and releasing toxin and preparation method |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104208175A (en) * | 2014-09-11 | 2014-12-17 | 江西九华药业有限公司 | Preparation method of cow-bezoar detoxicating tablet |
| CN106138254A (en) * | 2015-03-27 | 2016-11-23 | 索绪斌 | A kind of preparation method and applications of antiphlogistic bezoar buccal tablet |
| CN107648320A (en) * | 2017-06-26 | 2018-02-02 | 安徽永生堂药业有限责任公司 | A kind of detoxicating tablet of cow-bezoar and preparation method thereof |
| CN107802679A (en) * | 2017-12-13 | 2018-03-16 | 合肥凯石医药科技有限公司 | A kind of preparation method for the compound Chinese medicinal preparation for treating leukaemia |
| CN111920776A (en) * | 2020-08-03 | 2020-11-13 | 河北君临药业有限公司 | Preparation method of bezoar detoxicating tablet with definite curative effect |
| CN111920776B (en) * | 2020-08-03 | 2022-08-30 | 河北君临药业有限公司 | Preparation method of bezoar detoxicating tablet with definite curative effect |
| CN116370543A (en) * | 2023-04-20 | 2023-07-04 | 南京同仁堂药业有限责任公司 | Cattle yellow detoxification tablet and preparation method thereof |
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