CN107802679A - A kind of preparation method for the compound Chinese medicinal preparation for treating leukaemia - Google Patents
A kind of preparation method for the compound Chinese medicinal preparation for treating leukaemia Download PDFInfo
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- CN107802679A CN107802679A CN201711330226.8A CN201711330226A CN107802679A CN 107802679 A CN107802679 A CN 107802679A CN 201711330226 A CN201711330226 A CN 201711330226A CN 107802679 A CN107802679 A CN 107802679A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/36—Arsenic; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
Abstract
The invention provides a kind of preparation method for the compound Chinese medicinal preparation for treating leukaemia, comprise the following steps：(1) by realgar powder, taking precipitate, dry, finely ground, sour water elution are dry after fine grinding；(2) marumerization is used, the radix pseudostellariae of 100 mesh sieves will be crossed and the mixing medicinal material powder of indigo naturalis is put in fluid bed, by relative density be 1.1~1.2 red sage root clear cream using top spray pelletize by the way of, boiling granulating, drying at 60~70 DEG C, dry particl granularity were 30 mesh sieves；(3) it will be mixed through particle made from step (2) with fine powder made from step (1), and add magnesium stearate and be well mixed, tabletting, coating, produce；Realgar is added always mixed, tabletting in dry particl by the present invention using outer addition and magnesium stearate, avoid high temperature degradation, substantially reduce the toxicity of the compound Chinese medicinal preparation for the treatment of leukaemia, and make it have the effect of more preferable, by reducing the denseness of red sage root clear cream and using fluid-bed marumerization, making production cost and the time-consuming further reduction of production.
Description
Technical field
The present invention relates to Chinese medicine preparation preparing technical field, and in particular to a kind of compound Chinese medicinal preparation for treating leukaemia
Preparation method.
Background technology
The overall incidence of China's leukaemia is 2.76/10 ten thousand, and in mortality of malignant tumors, leukaemia occupies the 6th (man
Property) and the 8th (women), then occupy the 1st in adult in children and less than 35 years old.Acute leukemia is more common than chronic leukemia
(about 5.5：1)；Male's incidence of disease is slightly above women (about 1.81：1)；It is most with acute myeloblastic leukemia in adult leukemia
See, it is common with ALL in children；Chronic myelogenous leukemia increases with the age and the incidence of disease gradually rises.Root
According to《Chinese Journal of Hematology》The Chinese acute promyelocytic leukemia practice guidelines that the 5th phase of volume 35 in May, 2014 delivers
Show, acute promyelocytic leukemia (Acute promyelocyte leukemia, APL) is that one kind has specific gene
The specific type acute leukemia changed with karyotype.Clinical manifestation is dangerous, easily goes out in onset and therapeutic process
Blood and embolism and cause death.In the late two decades, due to the clinical practice of arsenical, APL turn into the leukaemia that can cure it
One.APL has seen young people, and average age of onset is 39 years old, and it is white that epidemiological study confirms that the external APL incidences of disease account for the same period
The 5~23.8% of blood disease, account for the 6.2~40.2% of acute myeloid leukemia.It is white that domestic multidigit scholar reports that the incidence of disease accounts for the same period
The 3.3~21.2% of blood disease.
Compound Chinese medicinal preparation compound realgar natural indigo tablet be it is a kind of be used for treat young grain of acute morning, chronic myelocytic leukemia it is oral
Arsenical, list for many years, clinical efficacy is notable, and prescription flavour of a drug are realgar, indigo naturalis, radix pseudostellariae, red sage root etc., contains in its prescription and controls
The main component for treating leukaemia is realgar, is in this place monarch drug in a prescription in side.Because realgar has unstability, heat is easily decomposed into As2O3
(arsenic), there is severe toxicity.Therefore can not heat, decocting enters decoction, for oral administration to be taken after fine grinding.Effect has removing toxic substances desinsection, eliminating dampness to dispel
Phlegm, preventing malaria.Clinically it is mainly used in carbuncle swells furunculosis, snake bite and insect sting, abdominal pain due to enterositosis, frightened epilepsy, malaria etc..Although realgar is to have poison
Thing, but clinical practice is very extensive, such as classic prescriptions Angong Niuhuang Wan, Liushen Pills, zijin troche, detoxicating tablet of cow-bezoar and children extremely
Treasure pill etc. is still largely using now.
More than 96% is up to using the effective percentage of realgar treatment acute promyelocytic leukemia in recent years, it is to acute leaching
Bar chronic myeloid leukemia, acute myeloblastic leukemia and chronic myelocytic leukemia also have good therapeutic effect.Wherein realgar
Main component is As2S2Or As4S4, experiment proves that the realgar toxicity by processing purifying is smaller, and the toxicity that arsenic is realgar is come
Source, there is water solubility, traditional concocting method reduces toxicity using elutriation, and modern age refines realgar on the basis of fine grinding
Acid adding is washed again, the toxicity of arsenic can be made to be reduced to minimum degree, content should be less than 0.17%.But prepared using existing process multiple
During square Huangdai tablet, by cross 100 mesh sieves medicinal material powder (radix pseudostellariae, realgar, indigo naturalis mix powder) with relative density be 1.3~1.35 (
50 DEG C of measure) red sage root clear cream mix softwood processed, pelletized 18 mesh sieve whole grains using 14 mesh sieves, drying more than the 6h less than 50 DEG C.
But Chinese medical concrete is difficult to drying below 50 DEG C, time-consuming, the production time is added production cost while growth, and if
Drying temperature is increased to more than 50 DEG C, then the degradable As for toxicity of the realgar of non-refractory2O3, now not only make compound yellow
The toxicity increase of black pigment used by women in ancient times to paint their eyebrows piece, the effect of also reducing compound realgar natural indigo tablet.Therefore a kind of minimum toxicity, curative effect enhancing and production consumption are developed
When short compound realgar natural indigo tablet production technology, there is great practical significance.
The content of the invention
It is an object of the invention to provide a kind of preparation method for the compound Chinese medicinal preparation for treating leukaemia, realgar is used
Outer addition adds always mixed, tabletting in dry particl together with magnesium stearate, avoids high temperature degradation, makes the Chinese medicine compound prescription for the treatment of leukaemia
The toxicity of preparation substantially reduces, and improves product quality and stability, and make it have the effect of more preferable；It is clear by reducing the red sage root
The denseness of cream and using fluid-bed marumerization, used time about 2~3h, shortens production process, makes production cost and production consumption
When further reduce.
To realize object above, the present invention is achieved by the following technical programs：
A kind of preparation method for the compound Chinese medicinal preparation for treating leukaemia, comprises the following steps：
(1) by realgar powder after fine grinding taking precipitate, it is dry, finely ground, then eluted using sour water, dry；
(2) marumerization is used, the radix pseudostellariae of 100 mesh sieves will be crossed and the mixing medicinal material powder of indigo naturalis is put in fluid bed, then
By red sage root clear cream that relative density is 1.1~1.2 using top spray granulation by the way of, boiling granulating, drying at 60~70 DEG C are dry
Grain graininess was 30 mesh sieves；
(3) will be mixed through particle made from step (2) with fine powder made from step (1), and it is equal to add magnesium stearate mixing
It is even, tabletting, coating, produce.
Preferably, the drying temperature in the step (1) is 38~42 DEG C.
Preferably, in the step (2), the relative density of red sage root clear cream is the measured value at 50 DEG C.
Preferably, in the step (2), steam or electrically heated mode is used to prepare relative density as 1.1~1.2 pellet
Join clear cream.
Preferably, in the step (2), medicinal material mix powder and clear cream using marumerization the top spray at 65 DEG C in fluid bed
Granulation is dried, dried, and dry particl granularity was 30 mesh sieves.
Preferably, in the step (3), the addition of magnesium stearate is 1%.
Preferably, in the step (3), the preparation method of coating solution used is during coating：Take gastric solubility film coating pre-
Mixture, the ethanol that volumetric concentration is 60~80% is added, be configured to the coating solution that mass concentration is 10~18%.
The specific preparation method of red sage root clear cream is：By the red sage root plus 10~14 times of amount water, decoct 3~5 times, every time 1~1.5h,
Filtration, 3~5 filtrates are merged, use steam or electrical heating to be concentrated into relative density as 1.1~1.2 (being determined at 50 DEG C)
Radix Salviae Miltiorrhizae extractum.
The beneficial effects of the invention are as follows：
1st, the present invention further reduces toxicity after realgar is eluted on the basis of fine grinding using sour water, and uses outer addition
With adding always mixed, tabletting in dry particl together with magnesium stearate, high temperature degradation is avoided, makes the compound Chinese medicinal preparation for the treatment of leukaemia
Toxicity substantially reduces, and makes it have the effect of more preferable.
2nd, the relative density of red sage root clear cream is adjusted to 1.1~1.2, clear cream is in streamline shape, diluter, can further reduce energy
Consumption.One-step palletizing is carried out using fluid bed, rate of drying is fast, improves stability of drug products；Eliminate softwood, granulation and whole grain mistake processed
Journey, man-hour is shortened, reduce production cost, be adapted to industrialized production.And less of particle diameter can be directly made in fluid bed
Grain, it is more preferable with male sulphur fine powder mixed effect.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with the embodiment of the present invention,
Technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is the present invention one
Divide embodiment, rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art are not making
The every other embodiment obtained under the premise of creative work, belongs to the scope of protection of the invention.
Embodiment 1：Treat the compound Chinese medicinal preparation of leukaemia
Prescription：Indigo naturalis 125g, realgar 30g, radix pseudostellariae 45g, red sage root 210g
Preparation method comprises the following steps：
(1) by realgar powder after fine grinding taking precipitate, be dried at 40 DEG C, it is finely ground, then eluted using sour water, 40 DEG C
Under be dried；
(2) red sage root is added into 10 times of amount water, decocted 3 times, each 1h, filtration, 3 filtrates are merged, heated using steam dense
It is reduced to the Radix Salviae Miltiorrhizae extractum that relative density is 1.2 (being determined at 50 DEG C)；The radix pseudostellariae and the mixing medicinal material of indigo naturalis that 100 mesh sieves will be crossed
Powder is put in fluid bed, and the red sage root clear cream boiling granulating, drying at 60 DEG C by the way of top spray, dry particl granularity was 30 mesh
Sieve；
(3) will be mixed through particle made from step (2) with fine powder made from step (1), and the magnesium stearate of addition 1% mixes
Close uniformly, tabletting, coating, produce.
The preparation method of coating solution used is during coating：Gastric solubility film coating pre-mix dose is taken, adding volumetric concentration is
80% ethanol, it is configured to the coating solution that mass concentration is 15%.
Embodiment 2：Treat the compound Chinese medicinal preparation of leukaemia
Prescription：Indigo naturalis 125g, realgar 30g, radix pseudostellariae 45g, red sage root 210g
Preparation method comprises the following steps：
(1) by realgar powder after fine grinding taking precipitate, be dried at 42 DEG C, it is finely ground, then eluted using sour water, 42 DEG C
Under be dried；
(2) red sage root is added into 14 times of amount water, decocted 3 times, each 1.5h, filtration, 3 filtrates are merged, heated using steam
It is concentrated into the Radix Salviae Miltiorrhizae extractum that relative density is 1.15 (being determined at 50 DEG C)；By the radix pseudostellariae for crossing 100 mesh sieves and the mixing of indigo naturalis
Medicinal material powder is put in fluid bed, and the red sage root clear cream boiling granulating, drying at 65 DEG C, dry particl granularity by the way of top spray were 30
Mesh sieve；
(3) will be mixed through particle made from step (2) with fine powder made from step (1), and the magnesium stearate of addition 1% mixes
Close uniformly, tabletting, coating, produce.
The preparation method of coating solution used is during coating：Gastric solubility film coating pre-mix dose is taken, adding volumetric concentration is
60% ethanol, it is configured to the coating solution that mass concentration is 10%.
Embodiment 3：Treat the compound Chinese medicinal preparation of leukaemia
Prescription：Indigo naturalis 125g, realgar 30g, radix pseudostellariae 45g, red sage root 210g
Preparation method comprises the following steps：
(1) by realgar powder after fine grinding taking precipitate, be dried at 38 DEG C, it is finely ground, then eluted using sour water, 38 DEG C
Under be dried；
(2) red sage root is added into 12 times of amount water, decocted 4 times, each 1h, filtration, 4 filtrates are merged, concentrated using electrical heating
Radix Salviae Miltiorrhizae extractum to relative density for 1.1 (being determined at 50 DEG C)；The radix pseudostellariae and indigo naturalis of 100 mesh sieves were added in red sage root clear cream
Mixing medicinal material powder put in fluid bed, the red sage root clear cream boiling granulating, drying, grain graininess at 70 DEG C by the way of top spray are
Cross 30 mesh sieves；
(3) will be mixed through particle made from step (2) with fine powder made from step (1), and the magnesium stearate of addition 1% mixes
Close uniformly, tabletting, coating, produce.
The preparation method of coating solution used is during coating：Gastric solubility film coating pre-mix dose is taken, adding volumetric concentration is
70% ethanol, it is configured to the coating solution that mass concentration is 18%.
Comparative example：Compound realgar natural indigo tablet
Prescription：Indigo naturalis 125g, realgar 30g, radix pseudostellariae 45g, red sage root 210g
Preparation method comprises the following steps：
(1) selected realgar, by realgar powder after flying water taking precipitate, it is finely ground after drying at 40 DEG C, it is standby；
(2) that radix pseudostellariae powder is broken into fine powder is standby；
(3) selected I grade or superfine indigo naturalis powder it is standby；
(4) fine powder of above-mentioned (1) (2) and (3) three kinds of medicine components is mixed standby；
(5) red sage root is added into 10 times of amount water, decocted 3 times, each 1h, filtration, 3 filtrates are merged, are concentrated into relative density
For the medicinal extract of 1.35 (being determined at 50 DEG C)；
(6) Radix Salviae Miltiorrhizae extractum is added in above-mentioned (4), i.e., in the mixing fine powder of above-mentioned three kinds of medicine components, mixed well, pelletized,
8~10h is dried at 50 DEG C, adds 1% magnesium stearate, mixes, whole grain, tabletting, coating, is made 1000, produces.
Quality testing：
The compound Chinese medicinal preparation obtained by technique that optimization will be passed through in embodiment 1 is prepared with comparative example Central Plains technique
Compound realgar natural indigo tablet carry out quality testing, the enterprise of the detection method of projects according to State Food and Drug Administration's approval
Standard (standard No. YBZ13122009) is detected.
Wherein：
The inspection method of arsenic trioxide is：
This product is taken, removes film-coating, precision weighs 0.80g, adds watery hydrochloric acid 20ml, is stirred continuously 30min, filters, residue
Washed 2 times, each 10ml with watery hydrochloric acid, stir 10min, washing lotion merges with filtrate, puts in 200ml measuring bottles, add water to scale, shake
Even, precision measures 2ml, adds hydrochloric acid 5ml and water 2ml.According to the arsenic inspection technique (F first of one annex of China's coastal port Ⅸ
Method) check, the aobvious arsenic spot color of institute must not be deeper than standard arsenic spot.
The content assaying method of realgar：
Take this product 20, remove film-coating, it is accurately weighed, it is finely ground, fine powder about 0.25g is taken, it is accurately weighed, put 250ml cones
In shape bottle, add potassium sulfate 1g, ammonium sulfate 2g and sulfuric acid 10ml, being heated to solution clarification with straight fire shows faint yellow, after letting cool, slowly
Add water 50ml, heat 3~5min of micro-boiling, let cool, add instructions phenolphthalein solution 2 to drip, it is micro- red to be neutralized to solution with sodium hydroxide solution
Color, let cool, be neutralized to solution decolourization with 0.25mol/L sulfuric acid solutions, add sodium acid carbonate 5g, iodine titration solution is used after shaking up
(0.1mol/L) is titrated, and during to nearly terminal, adds starch indicator solution 2ml, is titrated to solution and is shown hyacinthine, produces.Iodine per 1ml drips
Determine the orpiment of liquid (0.1mol/L) equivalent to 5.348mg.
Quality measurements are as shown in table 1：
The Quality Checkout Data of table 1 contrasts
After process modification, realgar does not detect the toxic component of arsenic trioxide, and former technique is male almost without degraded in sample
Huang has been degraded, and arsenic trioxide toxic component is exceeded, and it is reasonable to illustrate that realgar is added using outer addition after particle always mixes
Feasible, improve product stability and clinical efficacy；The content of technique assay index components after improvement apparently higher than
Former technique, show to use fluid-bed marumerization fluidized drying, not only shorten production process, reduce production cost, also carry
High product yield, is adapted to industrialized production.
The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although with reference to the foregoing embodiments
The present invention is described in detail, it will be understood by those within the art that：It still can be to foregoing each implementation
Technical scheme described in example is modified, or carries out equivalent substitution to which part technical characteristic；And these modification or
Replace, the essence of appropriate technical solution is departed from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (7)
1. a kind of preparation method for the compound Chinese medicinal preparation for treating leukaemia, it is characterised in that comprise the following steps：
(1) by realgar powder after fine grinding taking precipitate, it is dry, finely ground, then eluted using sour water, dry；
(2) marumerization is used, the radix pseudostellariae for crossing 100 mesh sieves and the mixing medicinal material powder of indigo naturalis are put in fluid bed, then by phase
To density be 1.1~1.2 red sage root clear cream using top spray pelletize by the way of, boiling granulating, drying, dry particl at 60~70 DEG C
Granularity was 30 mesh sieves；
(3) it will be mixed through particle made from step (2) with fine powder made from step (1), and add magnesium stearate and be well mixed, pressed
Piece, coating, is produced.
2. the preparation method of the compound Chinese medicinal preparation for the treatment of leukaemia according to claim 1, it is characterised in that the step
Suddenly the drying temperature in (1) is 38~42 DEG C.
3. the preparation method of the compound Chinese medicinal preparation for the treatment of leukaemia according to claim 1, it is characterised in that the step
Suddenly in (2), the relative density of red sage root clear cream is the measured value at 50 DEG C.
4. the preparation method of the compound Chinese medicinal preparation for the treatment of leukaemia according to claim 1, it is characterised in that the step
Suddenly in (2), steam or electrically heated mode is used to prepare relative density as 1.1~1.2 red sage root clear cream.
5. the preparation method of the compound Chinese medicinal preparation for the treatment of leukaemia according to claim 1, it is characterised in that the step
Suddenly in (2), medicinal material mix powder and clear cream using marumerization top spray granulation, fluidized drying, dry particl at 65 DEG C in fluid bed
Granularity was 30 mesh sieves.
6. the preparation method of the compound Chinese medicinal preparation for the treatment of leukaemia according to claim 1, it is characterised in that the step
Suddenly in (3), the addition of magnesium stearate is 1%.
7. the preparation method of the compound Chinese medicinal preparation for the treatment of leukaemia according to claim 1, it is characterised in that the step
Suddenly in (3), the preparation method of coating solution used is during coating：Gastric solubility film coating pre-mix dose is taken, it is 60 to add volumetric concentration
~80% ethanol, it is configured to the coating solution that mass concentration is 10~18%.
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|---|---|---|---|---|
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| CN1615970A (en) * | 2004-09-15 | 2005-05-18 | 中国人民解放军第210医院 | Chinese medicine preparation compound Huangdai tablet for treating leukemia and its jpreparing method |
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- 2017-12-13 CN CN201711330226.8A patent/CN107802679A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1569028A (en) * | 2003-07-22 | 2005-01-26 | 孙耀双 | Method and device for extracting and processing refined arsenic disulfide powder with water for medical use |
| CN1615970A (en) * | 2004-09-15 | 2005-05-18 | 中国人民解放军第210医院 | Chinese medicine preparation compound Huangdai tablet for treating leukemia and its jpreparing method |
| CN103006803A (en) * | 2012-11-23 | 2013-04-03 | 郑州瑞龙制药股份有限公司 | Preparation method of detoxicating tablet of cow-bezoar |
| CN105362340A (en) * | 2015-12-17 | 2016-03-02 | 亿帆鑫富药业股份有限公司 | Medicine composition for treating leukemia and preparation method thereof |
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| 崔红华等: ""雄黄的现代实验研究概况"", 《长春中医学院学报》 * |
| 贾天柱: "《中药炮制学》", 30 June 2013, 上海科学技术出版社 * |
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Effective date of abandoning: 20210709 |