CN104922295A - Blood-nourishing and blood-enriching traditional Chinese medicine composition - Google Patents
Blood-nourishing and blood-enriching traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a blood-nourishing and blood-enriching traditional Chinese medicine composition, and belongs to the field of medicines. Active ingredients of the pharmaceutical composition disclosed by the invention are astragalus or extract thereof, jujube or extract thereof, dried tangerine or orange peel or extract thereof and fructus lycii or extract thereof. The traditional Chinese medicine composition can be used for nourishing blood and enriching blood, and has beneficial effect which is unmatched by a single agent, on a human body. The drug is simple in production process, easy to take and remarkable in curative effect, and is an ideal blood-nourishing and blood-enriching traditional Chinese medicine composition.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of Chinese medicine composition nourishing blood, enrich blood.
Background technology
Anemia is the unsound state of one because hemopoietic insufficient raw material in blood or hematopoietic function reduce and cause, and the traditional Chinese medical science is then referred to as blood deficiency or the deficiency of vital energy.The origin cause of formation of anemia has a variety of, as congenital anemia, pathologic anemia, iron deficiency anemia and nutritional anemia etc.Also have the product being specifically designed to and enriching blood on the market now, these products are simple iron supplement mostly, or add inorganic iron or Organic Iron in the Chinese medicine preparation that routine is enriched blood.There is certain effect to iron deficiency anemia, nutritional anemia is then improved not quite.
Existing product of enriching blood mainly contains following three classes: pure Chinese medicine class, pure iron preparation class and Chinese medicine add ferrum class.Pure Chinese medicine class blood-supplementing preparation promotes the absorption of Dietary Iron mainly through promoting the functions such as human body taste, also can promote the hemopoietic function of medullary cell simultaneously, by nourishing blood and then enriching blood, but there is the defect of the iron supplement quantity not sufficient of onset slowly and to Patients with iron deficiency anemia; Simple iron preparation is then rapid-action, determined curative effect, but chalybeate ubiquity is to gastrointestinal defect excitatory, and mouthfeel is poor, also can contaminate black tooth tooth; Although existing Chinese medicine adds iron preparation compensate for both deficiency above, ubiquity combines irrational defect, because ferrum can not use with acid or alkaline Chinese medicine composition, combinationally uses and not only cannot produce synergism but also reduction and to enrich blood effect.
Summary of the invention
The Chinese medicine composition that the object of the invention is to provide a kind of for above-mentioned technical problem and nourish blood, enrich blood.
Object of the present invention can be achieved through the following technical solutions:
A Chinese medicine composition of nourish blood, enriching blood, the effective ingredient of this Chinese medicine composition is the Radix Astragali, Fructus Jujubae, Pericarpium Citri Reticulatae and Fructus Lycii, and forms by the raw material of following weight parts: the Radix Astragali 1 ~ 90 part, 1 ~ 90 part, Fructus Jujubae, Pericarpium Citri Reticulatae 1 ~ 90 part and Fructus Lycii 1 ~ 90 part.Preferably in this Chinese medicine composition: the parts by weight of the Radix Astragali, Fructus Jujubae, Pericarpium Citri Reticulatae and Fructus Lycii are followed successively by 2 ~ 80 parts, 4 ~ 75 parts, 3 ~ 80 parts and 4 ~ 80 parts.Further in this Chinese medicine composition preferred: the parts by weight of the Radix Astragali, Fructus Jujubae, Pericarpium Citri Reticulatae and Fructus Lycii are followed successively by 30 ~ 50 parts, 40 ~ 60 parts, 50 ~ 80 parts and 10 ~ 30 parts.Most preferably in this Chinese medicine composition: the parts by weight of the Radix Astragali, Fructus Jujubae, Pericarpium Citri Reticulatae and Fructus Lycii are followed successively by 40 parts, 50 parts, 60 parts and 20 parts.
The present invention further discloses following technical scheme, described in nourish blood, the Chinese medicine composition of enriching blood can also be any one combination in following combination.
The effective ingredient of Chinese medicine composition be in the Radix Astragali, Fructus Jujubae, Pericarpium Citri Reticulatae and Fructus Lycii any one with its extract for effective ingredient.Specific as follows:
The effective ingredient of Chinese medicine composition is Radix Astragali extract 1 ~ 90 part, 1 ~ 90 part, Fructus Jujubae, Pericarpium Citri Reticulatae 1 ~ 90 part and Fructus Lycii 1 ~ 90 part; Or the Radix Astragali 1 ~ 90 part, Fructus Jujubae extract 1 ~ 90 part, Pericarpium Citri Reticulatae 1 ~ 90 part and Fructus Lycii 1 ~ 90 part; Or the Radix Astragali 1 ~ 90 part, 1 ~ 90 part, Fructus Jujubae, Pericarpium Citri Reticulatae extract 1 ~ 90 part and Fructus Lycii 1 ~ 90 part; Or the Radix Astragali 1 ~ 90 part, 1 ~ 90 part, Fructus Jujubae, Pericarpium Citri Reticulatae 1 ~ 90 part and Fructus Lycii extract 1 ~ 90 part.
The effective ingredient of above-mentioned Chinese medicine composition is preferably: Radix Astragali extract 2 ~ 80 parts, 4 ~ 75 parts, Fructus Jujubae, Pericarpium Citri Reticulatae 3 ~ 80 parts and Fructus Lycii 4 ~ 80 parts; Or the Radix Astragali 2 ~ 80 parts, Fructus Jujubae extract 4 ~ 75 parts, Pericarpium Citri Reticulatae 3 ~ 80 parts and Fructus Lycii 4 ~ 80 parts; Or the Radix Astragali 2 ~ 80 parts, 4 ~ 75 parts, Fructus Jujubae, Pericarpium Citri Reticulatae extract 3 ~ 80 parts and Fructus Lycii 4 ~ 80 parts; Or the Radix Astragali 2 ~ 80 parts, 4 ~ 75 parts, Fructus Jujubae, Pericarpium Citri Reticulatae 3 ~ 80 parts and Fructus Lycii extract 4 ~ 80 parts.
The effective ingredient of above-mentioned Chinese medicine composition is more preferably: Radix Astragali extract 30 ~ 50 parts, 40 ~ 60 parts, Fructus Jujubae, Pericarpium Citri Reticulatae 50 ~ 80 parts and Fructus Lycii 10 ~ 30 parts; Or the Radix Astragali 30 ~ 50 parts, Fructus Jujubae extract 40 ~ 60 parts, Pericarpium Citri Reticulatae 50 ~ 80 parts and Fructus Lycii 10 ~ 30 parts; Or the Radix Astragali 30 ~ 50 parts, 40 ~ 60 parts, Fructus Jujubae, Pericarpium Citri Reticulatae extract 50 ~ 80 parts and Fructus Lycii 10 ~ 30 parts; Or the Radix Astragali 30 ~ 50 parts, 40 ~ 60 parts, Fructus Jujubae, Pericarpium Citri Reticulatae 50 ~ 80 parts and Fructus Lycii extract 10 ~ 30 parts.
The effective ingredient of above-mentioned Chinese medicine composition most preferably is: Radix Astragali extract 40 parts, 50 parts, Fructus Jujubae, Pericarpium Citri Reticulatae 60 parts and Fructus Lycii 20 parts; Or the Radix Astragali 40 parts, Fructus Jujubae extract 50 parts, Pericarpium Citri Reticulatae 60 parts and Fructus Lycii 20 parts; Or the Radix Astragali 40 parts, 50 parts, Fructus Jujubae, Pericarpium Citri Reticulatae extract 60 parts and Fructus Lycii 20 parts; Or the Radix Astragali 40 parts, 50 parts, Fructus Jujubae, Pericarpium Citri Reticulatae 60 parts and Fructus Lycii extract 20 parts.
The effective ingredient of Chinese medicine composition be in the Radix Astragali, Fructus Jujubae, Pericarpium Citri Reticulatae and Fructus Lycii any two kinds with its extract for effective ingredient.Specific as follows:
The effective ingredient of Chinese medicine composition is: Radix Astragali extract 1 ~ 90 part, Fructus Jujubae extract 1 ~ 90 part, Pericarpium Citri Reticulatae 1 ~ 90 part and Fructus Lycii 1 ~ 90 part; Or Radix Astragali extract 1 ~ 90 part, 1 ~ 90 part, Fructus Jujubae, Pericarpium Citri Reticulatae extract 1 ~ 90 part and Fructus Lycii 1 ~ 90 part; Or Radix Astragali extract 1 ~ 90 part, 1 ~ 90 part, Fructus Jujubae, Pericarpium Citri Reticulatae 1 ~ 90 part and wolfberry fruit extract 1 ~ 90 part; Or the Radix Astragali 1 ~ 90 part, Fructus Jujubae extract 1 ~ 90 part, Pericarpium Citri Reticulatae extract 1 ~ 90 part and Fructus Lycii 1 ~ 90 part; Or the Radix Astragali 1 ~ 90 part, Fructus Jujubae extract 1 ~ 90 part, Pericarpium Citri Reticulatae 1 ~ 90 part and Fructus Lycii extract 1 ~ 90 part; Or the Radix Astragali 1 ~ 90 part, 1 ~ 90 part, Fructus Jujubae, Pericarpium Citri Reticulatae extract 1 ~ 90 part and Fructus Lycii extract 1 ~ 90 part.
The effective ingredient of above-mentioned Chinese medicine composition is preferably: Radix Astragali extract 2 ~ 80 parts, Fructus Jujubae extract 4 ~ 75 parts, Pericarpium Citri Reticulatae 3 ~ 80 parts and Fructus Lycii 4 ~ 80 parts; Or Radix Astragali extract 2 ~ 80 parts, 4 ~ 75 parts, Fructus Jujubae, Pericarpium Citri Reticulatae extract 3 ~ 80 parts and Fructus Lycii 4 ~ 80 parts; Or Radix Astragali extract 2 ~ 80 parts, 4 ~ 75 parts, Fructus Jujubae, Pericarpium Citri Reticulatae 3 ~ 80 parts and Fructus Lycii extract 4 ~ 80 parts; Or the Radix Astragali 2 ~ 80 parts, Fructus Jujubae extract 4 ~ 75 parts, Pericarpium Citri Reticulatae extract 3 ~ 80 parts and Fructus Lycii 4 ~ 80 parts; Or the Radix Astragali 2 ~ 80 parts, Fructus Jujubae extract 4 ~ 75 parts, Pericarpium Citri Reticulatae 3 ~ 80 parts and Fructus Lycii extract 4 ~ 80 parts; Or the Radix Astragali 2 ~ 80 parts, 4 ~ 75 parts, Fructus Jujubae, Pericarpium Citri Reticulatae extract 3 ~ 80 parts and Fructus Lycii extract 4 ~ 80 parts.
The effective ingredient of above-mentioned Chinese medicine composition is more preferably: Radix Astragali extract 30 ~ 50 parts, Fructus Jujubae extract 40 ~ 60 parts, Pericarpium Citri Reticulatae 50 ~ 80 parts and Fructus Lycii 10 ~ 30 parts; Or Radix Astragali extract 30 ~ 50 parts, 40 ~ 60 parts, Fructus Jujubae, Pericarpium Citri Reticulatae extract 50 ~ 80 parts and Fructus Lycii 10 ~ 30 parts; Or Radix Astragali extract 30 ~ 50 parts, 40 ~ 60 parts, Fructus Jujubae, Pericarpium Citri Reticulatae 50 ~ 80 parts and Fructus Lycii extract 10 ~ 30 parts; Or the Radix Astragali 30 ~ 50 parts, Fructus Jujubae extract 40 ~ 60 parts, Pericarpium Citri Reticulatae extract 50 ~ 80 parts and Fructus Lycii 10 ~ 30 parts; Or the Radix Astragali 30 ~ 50 parts, Fructus Jujubae extract 40 ~ 60 parts, Pericarpium Citri Reticulatae 50 ~ 80 parts and Fructus Lycii extract 10 ~ 30 parts; Or the Radix Astragali 30 ~ 50 parts, 40 ~ 60 parts, Fructus Jujubae, Pericarpium Citri Reticulatae extract 50 ~ 80 parts and Fructus Lycii extract 10 ~ 30 parts.
The effective ingredient of above-mentioned Chinese medicine composition most preferably is: Radix Astragali extract 40 parts, Fructus Jujubae extract 50 parts, Pericarpium Citri Reticulatae 60 parts and Fructus Lycii 20 parts; Or Radix Astragali extract 40 parts, 50 parts, Fructus Jujubae, Pericarpium Citri Reticulatae extract 60 parts and Fructus Lycii 20 parts; Or Radix Astragali extract 40 parts, 50 parts, Fructus Jujubae, Pericarpium Citri Reticulatae 60 parts and Fructus Lycii 20 parts of extracts; Or the Radix Astragali 40 parts, Fructus Jujubae extract 50 parts, Pericarpium Citri Reticulatae extract 60 parts and Fructus Lycii 20 parts; Or the Radix Astragali 40 parts, Fructus Jujubae extract 50 parts, Pericarpium Citri Reticulatae 60 parts and Fructus Lycii 20 extract part; Or the Radix Astragali 40 parts, 50 parts, Fructus Jujubae, Pericarpium Citri Reticulatae extract 60 parts and Fructus Lycii extract 20 parts.
The effective ingredient of Chinese medicine composition be in the Radix Astragali, Fructus Jujubae, Pericarpium Citri Reticulatae and Fructus Lycii any three kinds with its extract for effective ingredient.Specific as follows:
The effective ingredient of Chinese medicine composition is: Radix Astragali extract 1 ~ 90 part, Fructus Jujubae extract 1 ~ 90 part, Pericarpium Citri Reticulatae extract 1 ~ 90 part and Fructus Lycii 1 ~ 90 part; Or Radix Astragali extract 1 ~ 90 part, Fructus Jujubae extract 1 ~ 90 part, Pericarpium Citri Reticulatae 1 ~ 90 part and Fructus Lycii extract 1 ~ 90 part; Or Radix Astragali extract 1 ~ 90 part, 1 ~ 90 part, Fructus Jujubae, Pericarpium Citri Reticulatae extract 1 ~ 90 part and Fructus Lycii extract 1 ~ 90 part; Or the Radix Astragali 1 ~ 90 part, Fructus Jujubae extract 1 ~ 90 part, Pericarpium Citri Reticulatae extract 1 ~ 90 part and Fructus Lycii extract 1 ~ 90 part.
The effective ingredient of above-mentioned Chinese medicine composition is preferably: Radix Astragali extract 2 ~ 80 parts, Fructus Jujubae extract 4 ~ 75 parts, Pericarpium Citri Reticulatae extract 3 ~ 80 parts and Fructus Lycii 4 ~ 80 parts; Or Radix Astragali extract 2 ~ 80 parts, Fructus Jujubae extract 4 ~ 75 parts, Pericarpium Citri Reticulatae 3 ~ 80 parts and Fructus Lycii extract 4 ~ 80 parts; Or Radix Astragali extract 2 ~ 80 parts, 4 ~ 75 parts, Fructus Jujubae, Pericarpium Citri Reticulatae extract 3 ~ 80 parts and Fructus Lycii extract 4 ~ 80 parts; Or the Radix Astragali 2 ~ 80 parts, Fructus Jujubae extract 4 ~ 75 parts, Pericarpium Citri Reticulatae extract 3 ~ 80 parts and Fructus Lycii extract 4 ~ 80 parts.
The effective ingredient of above-mentioned Chinese medicine composition most preferably is: Radix Astragali extract 40 parts, Fructus Jujubae extract 50 parts, Pericarpium Citri Reticulatae extract 60 parts and Fructus Lycii 20 parts; Or Radix Astragali extract 40 parts, Fructus Jujubae extract 50 parts, Pericarpium Citri Reticulatae 60 parts and Fructus Lycii extract 20 parts; Or Radix Astragali extract 40 parts, 50 parts, Fructus Jujubae, Pericarpium Citri Reticulatae extract 60 parts and Fructus Lycii extract 20 parts; Or the Radix Astragali 40 parts, Fructus Jujubae extract 50 parts, Pericarpium Citri Reticulatae extract 60 parts and Fructus Lycii extract 20 parts.
The effective ingredient of Chinese medicine composition be in the Radix Astragali, Fructus Jujubae, Pericarpium Citri Reticulatae and Fructus Lycii four kinds with its extract for effective ingredient.Specific as follows:
Radix Astragali extract 1 ~ 90 part, Fructus Jujubae extract 1 ~ 90 part, Pericarpium Citri Reticulatae extract 1 ~ 90 part and Fructus Lycii extract 1 ~ 90 part.Preferably in this Chinese medicine composition: the parts by weight of Radix Astragali extract, Fructus Jujubae extract, Pericarpium Citri Reticulatae extract and Fructus Lycii extract are followed successively by 2 ~ 80 parts, 4 ~ 75 parts, 3 ~ 80 parts and 4 ~ 80 parts.Further in this Chinese medicine composition preferred: the parts by weight of Radix Astragali extract, Fructus Jujubae extract, Pericarpium Citri Reticulatae extract and Fructus Lycii extract are followed successively by 30 ~ 50 parts, 40 ~ 60 parts, 50 ~ 80 parts and 10 ~ 30 parts.Most preferably in this Chinese medicine composition: the parts by weight of Radix Astragali extract, Fructus Jujubae extract, Pericarpium Citri Reticulatae extract and Fructus Lycii extract are followed successively by 40 parts, 50 parts, 60 parts and 20 parts.
The extract of organic solvent that described Fructus Jujubae extract is Fructus Jujubae water or dissolves each other with water.
The extract of organic solvent that described Radix Astragali extract is Radix Astragali water or dissolves each other with water.
The extract of organic solvent that described Pericarpium Citri Reticulatae extract is Pericarpium Citri Reticulatae water or dissolves each other with water.
The extract of organic solvent that described Fructus Lycii extract is Fructus Lycii water or dissolves each other with water.
The described organic solvent dissolved each other with water is any one in methanol, ethanol, acetone.
Extracting method used be decoct in extraction, reflux, extract, soak extraction, supersound extraction or seepage pressure effects any one or a few.
After effective ingredient mixing in above-mentioned composition, add the acceptable adjuvant of pharmaceutics, make clinical acceptable dosage form; Described dosage form is the preparation of peroral dosage form, Tabules or capsule formulation.
Chinese medicine composition described in technical solution of the present invention nourishes blood in preparation, purposes in blood-tonifying health-care medicine.
Fructus Jujubae involved in the present invention has another name called Fructus Jujubae, is Rhamnaceae, zizyphus, Fructus Jujubae kind.Fructus Jujubae has high nutrition and medical value, phosphorous, the necessary trace element of human body such as ferrum, calcium.Fructus Jujubae can QI and blood regulating, profit cardiopulmonary, the kidney invigorating stomach, to treat heat cold.The traditional Chinese medical science is mainly used in treating hepatitis, and in addition, Fructus Jujubae also has the important function such as blood fat reducing, cholesterol reducing.Fructus Jujubae in the present invention is comprised the Fructus Jujubae fine powder after grinding, is obtained other processing forms of Fructus Jujubae extract or Fructus Jujubae by various processes.
The Radix Astragali described in technical solution of the present invention is pulse family Astragalus.A kind of plant with very high medical value, can enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.The described Radix Astragali comprises after processing is refined Radix Astragali extract, various forms after grinding in Radix Astragali fine powder or Radix Astragali growth course.
Pericarpium Citri Reticulatae described in technical solution of the present invention is the dry mature skin of rutaceae orange and variety thereof.Pericarpium Citri Reticulatae can be used for regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Described Pericarpium Citri Reticulatae comprise through processing refine after Pericarpium Citri Reticulatae extract, after grinding Pericarpium Citri Reticulatae fine powder.
The mature fruit that Fructus Lycii described in technical solution of the present invention is matrimony vine of solanaceae plant.There is nourishing the liver and kidney, effect of replenishing vital essence to improve eyesight.Described Fructus Lycii comprises after processing is refined Fructus Lycii extract, various forms after grinding in Fructus Lycii fine powder or Fructus Lycii growth course.
After in the present invention, the definition of " collaborative raising " can be understood as the combination of several medical material, its drug effect is relative to improve when being used alone; Drug effect is more lasting; Compositions produces beyond thought effect in new control or healthcare field.
Inventor is found by test, and compositions of the present invention has the function nourishing blood, enrich blood.These single doses by after a certain proportion of compositions to the beneficial effect of human body effect be single dose incomparable.
Compositions of the present invention also can be processed into slow releasing preparation or quick releasing formulation.Wherein said pharmaceutically acceptable carrier or excipient are selected according to different dosage forms.These carriers used or excipient can determine for the those of ordinary skill of pharmaceutical field.
The preparation method of oral liquid, can but be not only confined to following one, after active component is mixed, decoct with water, decoction liquor is filtered, obtain solution, obtain extractum by concentrated for gained solution, then gained extractum is dissolved in the concentration of extractum weight 5-10 times weight is in the ethanol water according to weighing scale 95%, is uniformly mixed, quantitative separating, obtains oral liquid formulations.
The preparation method of tablet is sieved by active component mixture, and after pulverizing at the auxiliary agent conventional with preparing tablet, fully mixing homogeneously, mistake 40-80 eye mesh screen, is pressed into tablet by tabletting by direct for dry powder machine.
The preparation technology of capsule preparations can be sieved by active component mixture, and after pulverizing at the auxiliary agent conventional with preparing tablet, fully mixing homogeneously, cross 40-80 eye mesh screen, by granulating, drying, fills with capsule, polishing after the operations such as granulate, packs, gets product.
Beneficial effect of the present invention:
The effective ingredient of pharmaceutical composition of the present invention is the Radix Astragali or its extract, Fructus Jujubae or its extract, Pericarpium Citri Reticulatae or its extract and Fructus Lycii or its extract, this Chinese medicine composition may be used for nourishing blood, enriching blood, the beneficial effect of this Chinese medicine composition to human body effect be single dose incomparable.The production technology of this medicine is simple, be easy to take, evident in efficacy, be a kind of desirable Chinese medicine composition nourishing blood, enrich blood.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but protection scope of the present invention is not limited thereto:
Embodiment 1
Crude drug forms: Radix Astragali extract 30 parts, Fructus Jujubae extract 60 parts, Pericarpium Citri Reticulatae 50 parts and Fructus Lycii 30 parts
Prepared by Radix Astragali water extract: the Radix Astragali is soaked 40 minutes, the water surface, higher than raw material Chinese medicine, adds 8 times that water inventory is total dose, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decocts 2 hours, cross leaching filtrate, add the water of 6 times of total dose again, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decoct 2 hours, filter merging twice filtrate, be Radix Astragali water extract through concentrating under reduced pressure (pressure 0.06Mpa, temperature 65 DEG C) to the dry cream of the Radix Astragali;
Prepared by Fructus Jujubae water extract: Fructus Jujubae is soaked 40 minutes, the water surface, higher than raw material Chinese medicine, adds 8 times that water inventory is total dose, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decocts 2 hours, cross leaching filtrate, add the water of 6 times of total dose again, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decoct 2 hours, filter merging twice filtrate, be Fructus Jujubae water extract through concentrating under reduced pressure (pressure 0.06Mpa, temperature 65 DEG C) to the dry cream of Fructus Jujubae;
Finally by Radix Astragali extract 30 parts, Fructus Jujubae extract 60 parts, Pericarpium Citri Reticulatae 50 parts and Fructus Lycii 30 parts mixing, the concentration of water-soluble extract gross weight 5-10 times weight is in the ethanol water according to weighing scale 95%, be uniformly mixed, quantitative separating, obtain oral liquid formulations.
Embodiment 2
Crude drug forms: the Radix Astragali 30 parts, 60 parts, Fructus Jujubae, Pericarpium Citri Reticulatae 50 parts and Fructus Lycii 30 parts.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 3
Crude drug forms: Radix Astragali extract 40 parts, Fructus Jujubae extract 50 parts, Pericarpium Citri Reticulatae extract 60 parts and Fructus Lycii extract 20 parts.
Prepared by Radix Astragali ethanol extraction: adopted by the Radix Astragali 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Radix Astragali extract.
Prepared by Fructus Jujubae ethanol extraction: adopted by Fructus Jujubae 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Fructus Jujubae extract.
Prepared by Pericarpium Citri Reticulatae ethanol extraction: adopted by Pericarpium Citri Reticulatae 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Pericarpium Citri Reticulatae extract.
Prepared by Fructus Lycii ethanol extraction: adopted by Fructus Lycii 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Fructus Lycii extract.
Radix Astragali extract 40 parts, Fructus Jujubae extract 50 parts, Pericarpium Citri Reticulatae extract 60 parts be dry, pulverize into fine powder respectively with Fructus Lycii extract 20 parts, sieve, mixing, granulate, be pressed into tablet.
Embodiment 4
Crude drug forms: the Radix Astragali 40 parts, 50 parts, Fructus Jujubae, Pericarpium Citri Reticulatae 60 parts and Fructus Lycii 20 parts.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 5
Crude drug forms: Radix Astragali extract 50 parts, Fructus Jujubae extract 40 parts, Pericarpium Citri Reticulatae extract 80 parts and Fructus Lycii 10 parts.
Prepared by Radix Astragali ethanol extraction: adopted by the Radix Astragali 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Radix Astragali extract.
Prepared by Fructus Jujubae ethanol extraction: adopted by Fructus Jujubae 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Fructus Jujubae extract.
Prepared by Pericarpium Citri Reticulatae ethanol extraction: adopted by Pericarpium Citri Reticulatae 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Pericarpium Citri Reticulatae extract.
Aforementioned Radix Astragali extract 50 parts, Fructus Jujubae extract 40 parts, Pericarpium Citri Reticulatae extract 80 parts and Fructus Lycii 10 parts are ground into fine powder, sieve, mixing, adds the magnesium stearate of gross weight 2%, incapsulates.
Embodiment 6
Crude drug forms: the Radix Astragali 50 parts, 40 parts, Fructus Jujubae, Pericarpium Citri Reticulatae 80 parts and Fructus Lycii 10 parts
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 7
Crude drug forms: Radix Astragali extract 10 parts, 30 parts, Fructus Jujubae, Pericarpium Citri Reticulatae 40 parts and Fructus Lycii 10 parts
Prepared by Radix Astragali water extract: the Radix Astragali is soaked 40 minutes, the water surface, higher than raw material Chinese medicine, adds 8 times that water inventory is total dose, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decocts 2 hours, cross leaching filtrate, add the water of 6 times of total dose again, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decoct 2 hours, filter merging twice filtrate, be Radix Astragali water extract through concentrating under reduced pressure (pressure 0.06Mpa, temperature 65 DEG C) to the dry cream of the Radix Astragali;
Radix Astragali extract 10 parts, 30 parts, Fructus Jujubae, Pericarpium Citri Reticulatae 40 parts and Fructus Lycii 10 parts of mixing are broken into fine powder, sieve, add the magnesium stearate of gross weight 2%, incapsulate.
Embodiment 8
Crude drug forms: the Radix Astragali 10 parts, 30 parts, Fructus Jujubae, Pericarpium Citri Reticulatae 40 parts and Fructus Lycii 10 parts.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 9
Crude drug forms: the Radix Astragali 80 parts, Fructus Jujubae extract 50 parts, Pericarpium Citri Reticulatae extract 13 parts and Fructus Lycii 25 parts.
Prepared by Fructus Jujubae ethanol extraction: adopted by Fructus Jujubae 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Fructus Jujubae extract.
Prepared by Pericarpium Citri Reticulatae ethanol extraction: adopted by Pericarpium Citri Reticulatae 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Pericarpium Citri Reticulatae extract.
The Radix Astragali 80 parts, Fructus Jujubae extract 50 parts, Pericarpium Citri Reticulatae extract 13 parts and Fructus Lycii 25 parts are dried and crushed into fine powder, sieve, mixing, granulate, be pressed into tablet.
Embodiment 10
Crude drug forms: the Radix Astragali 80 parts, 50 parts, Fructus Jujubae, Pericarpium Citri Reticulatae 13 parts and Fructus Lycii 25 parts
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
1, Ergonomy experiment
Selected mice is SD rat; Dosage choice: low dose group 0.8g/kg (embodiment 3), middle dosage group 1.7g/kg (embodiment 3), high dose group 5g/kg (embodiment 3).
1. experimental nutritional anemia rat model is set up
After SD rat being placed in laboratory environment adaptation 5d, 10 give normal rat normal feedstuff and normal drinking water, as blank group, all the other 40 give low ferrum feedstuff and drink deionized water, adopt tail blood examination after 20d and survey hemoglobin (Hb), using hemoglobin (Hb) lower than the rat of 100g/L as nutritional anemia animal pattern.The Anemia in Rats obtained is divided at random model group (10) and this compositions basic, normal, high dosage group (each 10).The each treated animal of experimental session continues the low ferrum feedstuff of feed and drinks deionized water (gavage gives 10mL/kg deionized water), basic, normal, high dosage component does not give blood tonifying compound 0.8mL/kg, 1.7mL/kg, 5.00mL/kg (being equivalent to 5,10,30 times of human body recommended amounts every day respectively) of present embodiment, continuous 30d, measures body weight and hemoglobin (Hb), RBC number (RBC), packed cell volume (HCT), Erythrocyte chemokine recepter (FEP), total iron binding capacity.RBC number (RBC), packed cell volume (HCT) value is measured with full-automatic blood counting instrument; Total iron binding capacity is measured with full automatic biochemical apparatus; With spectrophotometric determination hemoglobin (Hb); With fluorescent spectrophotometer assay Erythrocyte chemokine recepter (FEP).
This compositions of table 1 is on the impact of nutritional anemia rat hemoglobin (Hb)
From table 1, model group has significant reduction compared with the hemoglobin of blank group, and modeling success is described.And Chinese medicine composition of the present invention comparatively model group, the content of hemoglobin of Chinese medicine composition group of the present invention has significant lifting.Therefore we are easy to find out, after taking Chinese medicine composition of the present invention, the Anemia of SD rat is significantly improved.
This compositions of table 2 is on the impact of nutritional anemia rat RBC, HTC value
| Group | Number of elements (only) | RBC/10 12.L -1 | HTC/％ |
| Blank group | 10 | 7.46±0.12 | 68.55±7.94 |
| Model group | 10 | 5.10±0.36 | 42.19±5.39 |
| Low dose group | 10 | 7.22±0.24 | 54.23±7.26 |
| Middle dosage group | 10 | 7.36±0.39 | 60.42±8.78 |
| High dose group | 10 | 7.40±0.27 | 68.19±8.62 |
Table 2 is for Chinese medicine composition of the present invention is on the impact of nutritional anemia rat RBC, HCT, and the RBC number (RBC) of Chinese medicine composition of the present invention raises, and more all has significant rising with model group.Chinese medicine composition group Rat Erythrocytes hematocrit (HCT) of the present invention raises, also there is significant difference compared with model group, illustrate that the rising of the blood tonifying compound of present embodiment to the RBC number (RBC) of rat and packed cell volume (HCT) sum has facilitation.
This compositions of table 3 is on the impact of protoporphyrin (FEP) content free in nutritional anemia Rat Erythrocytes, total iron binding capacity
From table 3, we are apparent can find out, in Chinese medicine composition of the present invention each dosage group Rat Erythrocytes, free protoporphyrin (FEP) content is lower than model group; The total iron binding capacity of each dosage group of Chinese medicine composition of the present invention is all lower than model group.
To sum up: the data of table 1 ~ 3 show, Chinese medicine composition of the present invention improves significantly to anemia tool.
2, clinical experiment
Experimental subject: all case history is certain institute 2005-2012 out-patient, whole patient is all pale complexion because blood deficiency or the deficiency of vital energy cause or micro-Huang, fatigue and weakness, severe palpitation, the devices such as insomnia and dreamful sleep.
Method of administration and the course for the treatment of: each 6g of oral liquid, every day 3 times; Each 4 of capsule, every day 3 times; The each 4.5g of tablet, every day 3 times, being March course for the treatment of.
Experimenter of the present invention takes the embodiment of the present invention 1 ~ 10 respectively; Pericarpium Citri Reticulatae; The Radix Astragali; Pericarpium Citri Reticulatae+Radix Astragali (1:1); Pericarpium Citri Reticulatae+the Radix Astragali+Fructus Jujubae (1:1:1); Fructus Lycii+Fructus Jujubae+Radix Astragali (1:1:1).
Efficacy assessment standard: remarkable, effective and invalid.
Effective: though clinical symptoms is eliminated, curative effect is consolidated not.
Effective: clinical symptoms and sign make moderate progress.
Invalid: unchanged before treatment.
Therapeutic effect:
Table 4 Chinese medicine composition of the present invention is to the therapeutic effect of patient
| Compositions | Number of cases | Significantly | Effectively | Invalid | Total effective rate |
| Embodiment 1 | 101 | 50 | 34 | 17 | 83.2％ |
| Embodiment 2 | 114 | 66 | 30 | 18 | 84.2％ |
| Embodiment 3 | 103 | 53 | 33 | 17 | 83.5％ |
| Embodiment 4 | 126 | 67 | 40 | 19 | 85.0％ |
| Embodiment 5 | 117 | 71 | 30 | 16 | 86.3％ |
| Embodiment 6 | 106 | 63 | 30 | 13 | 87.7％ |
| Embodiment 7 | 102 | 42 | 44 | 16 | 84.3％ |
| Embodiment 8 | 109 | 40 | 52 | 17 | 84.4％ |
| Embodiment 9 | 102 | 40 | 45 | 17 | 83.3％ |
| Embodiment 10 | 103 | 38 | 47 | 18 | 82.5％ |
| Pericarpium Citri Reticulatae | 81 | 14 | 10 | 57 | 29.6％ |
| The Radix Astragali | 62 | 16 | 14 | 32 | 48.4％ |
| Pericarpium Citri Reticulatae+Radix Astragali | 75 | 21 | 20 | 34 | 54.7％ |
| Pericarpium Citri Reticulatae+the Radix Astragali+Fructus Jujubae | 87 | 32 | 20 | 35 | 59.8％ |
| Fructus Lycii+Fructus Jujubae+Radix Astragali | 92 | 37 | 20 | 35 | 62.0％ |
As can be seen from Table 4, the Chinese medicine composition of technical solution of the present invention has good curative effect to vigorate qi and replenish the blood, and the beneficial effect of this Chinese medicine composition to human body effect be single dose incomparable.
Claims (10)
1. the Chinese medicine composition nourishing blood, enrich blood, it is characterized in that: the effective ingredient of this Chinese medicine composition is the Radix Astragali, Fructus Jujubae, Pericarpium Citri Reticulatae and Fructus Lycii, and forms by the raw material of following weight parts: the Radix Astragali 1 ~ 90 part, 1 ~ 90 part, Fructus Jujubae, Pericarpium Citri Reticulatae 1 ~ 90 part and Fructus Lycii 1 ~ 90 part.
2. the Chinese medicine composition nourishing blood, enrich blood according to claim 1, is characterized in that: the parts by weight of the Radix Astragali, Fructus Jujubae, Pericarpium Citri Reticulatae and Fructus Lycii are followed successively by 2 ~ 80 parts, 4 ~ 75 parts, 3 ~ 80 parts and 4 ~ 80 parts.
3. the Chinese medicine composition nourishing blood, enrich blood according to claim 2, is characterized in that: the parts by weight of the Radix Astragali, Fructus Jujubae, Pericarpium Citri Reticulatae and Fructus Lycii are followed successively by 30 ~ 50 parts, 40 ~ 60 parts, 50 ~ 80 parts and 10 ~ 30 parts.
4. the Chinese medicine composition nourishing blood, enrich blood according to claim 3, is characterized in that: the parts by weight of the Radix Astragali, Fructus Jujubae, Pericarpium Citri Reticulatae and Fructus Lycii are followed successively by 40 parts, 50 parts, 60 parts and 20 parts.
5. the Chinese medicine composition nourishing blood, enrich blood according to claim 1, is characterized in that: in the Radix Astragali, Fructus Jujubae, Pericarpium Citri Reticulatae and Fructus Lycii at least one with the form of its extract for effective ingredient.
6. the Chinese medicine composition nourishing blood, enrich blood according to claim 5, is characterized in that: the extractive with organic solvent that Radix Astragali extract is Radix Astragali water or dissolves each other with water; The extract of organic solvent that Fructus Jujubae extract is Fructus Jujubae water or dissolves each other with water; The extract of organic solvent that Pericarpium Citri Reticulatae extract is Pericarpium Citri Reticulatae water or dissolves each other with water; The extract of organic solvent that Fructus Lycii extract is Fructus Lycii water or dissolves each other with water; The described organic solvent dissolved each other with water is any one in methanol, ethanol, acetone; Extracting method be decoct in extraction, reflux, extract, soak extraction, supersound extraction or seepage pressure effects any one or a few.
7. the Chinese medicine composition nourishing blood, enrich blood according to any one of claim 1-4, is characterized in that: after the effective ingredient mixing of compositions, add the acceptable adjuvant of pharmaceutics, make clinical acceptable dosage form; Described dosage form is the preparation of peroral dosage form, Tabules or capsule formulation.
8. the Chinese medicine composition nourishing blood, enrich blood according to claim 5, is characterized in that: after the effective ingredient mixing of compositions, add the acceptable adjuvant of pharmaceutics, make clinical acceptable dosage form; Described dosage form is the preparation of peroral dosage form, Tabules or capsule formulation.
9. the Chinese medicine composition described in any one of claim 1-4 nourishes blood in preparation, purposes in blood-tonifying health-care medicine.
10. Chinese medicine composition according to claim 5 nourish blood in preparation, purposes in blood-tonifying health-care medicine.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107616271A (en) * | 2017-08-31 | 2018-01-23 | 王双亮 | A kind of preparation method of sophora bud tonifying speen and tonifying kidney tea |
| CN111437318A (en) * | 2020-06-03 | 2020-07-24 | 四川新绿色药业科技发展有限公司 | Traditional Chinese medicine soft extract for treating qi-blood deficiency syndrome and preparation method thereof |
| WO2021120972A1 (en) * | 2019-12-17 | 2021-06-24 | 四川新绿色药业科技发展有限公司 | Traditional chinese medicine composition for treating deficiency of both qi and blood, preparation method therefor and use thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103549561A (en) * | 2013-11-23 | 2014-02-05 | 王芬 | Health-protection soup capable of improving anemia and poor health |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103549561A (en) * | 2013-11-23 | 2014-02-05 | 王芬 | Health-protection soup capable of improving anemia and poor health |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107616271A (en) * | 2017-08-31 | 2018-01-23 | 王双亮 | A kind of preparation method of sophora bud tonifying speen and tonifying kidney tea |
| WO2021120972A1 (en) * | 2019-12-17 | 2021-06-24 | 四川新绿色药业科技发展有限公司 | Traditional chinese medicine composition for treating deficiency of both qi and blood, preparation method therefor and use thereof |
| CN111437318A (en) * | 2020-06-03 | 2020-07-24 | 四川新绿色药业科技发展有限公司 | Traditional Chinese medicine soft extract for treating qi-blood deficiency syndrome and preparation method thereof |
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Application publication date: 20150923 |