CN103877513A - Chinese herbal compound composition with blood fat reduction effect, and applications thereof - Google Patents
Chinese herbal compound composition with blood fat reduction effect, and applications thereof Download PDFInfo
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Abstract
本发明公开了一种具有降血脂功效的中药复方组合物，该组合物由银杏叶提取物0.5~2份，荷叶45~180份，杜仲叶3~12份，马齿苋3~12份，绞股蓝45~180份，山楂50~200份，姜黄45~180份，酸枣仁15~60份制成。本发明在中医药理论的指导下，采用辨证施治，结合高脂血症的发病机理和发病症状，筛选组方，整个组合物配比科学合理，实验结果表明，本发明提供的中药复方组合物，具有很好的降血脂的功效，可防治动脉粥样硬化，防治心血管疾病，并且组合物中各药味为药食同源的原料，疗效好，毒副作用低，临床用药更加安全。The invention discloses a traditional Chinese medicine compound composition with the effect of lowering blood fat. The composition comprises 0.5-2 parts of ginkgo leaf extract, 45-180 parts of lotus leaf, 3-12 parts of eucommia leaf, and 3-12 parts of purslane , 45-180 parts of Jiaogulan, 50-200 parts of hawthorn, 45-180 parts of turmeric, and 15-60 parts of jujube seed. Under the guidance of the theory of traditional Chinese medicine, the present invention adopts syndrome differentiation and treatment, and combines the pathogenesis and symptoms of hyperlipidemia to screen prescriptions. The proportion of the whole composition is scientific and reasonable. The medicine has good blood lipid-lowering effect, can prevent and treat atherosclerosis, and prevent and treat cardiovascular diseases, and the medicinal flavors in the composition are raw materials of the same medicine and food, with good curative effect, low toxic and side effects, and safer clinical use.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Traditional Chinese medicine compound composition and application thereof with blood fat reducing function.
Background technology
Hyperlipemia is mainly T-CHOL (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) raises and HDL-C (HDL-C) reduction causes.This is also to cause coronary artery disease and atherosclerotic one large index.The treatment of hyperlipemia comprises diet control, motion and Drug therapy.Prior art Chinese medicine and western medicine lipid lowerers comprises Statins, fibrate, has certain clinical efficacy, but all has untoward reaction or contraindication.
Chinese medicine has unique curative effect preventing and treating aspect hyperlipemia, and be mainly that clinical safety is good, toxic and side effects is little, therefore, necessary under the guidance of Chinese medical theory, optimize one and there is good blood fat reducing function, and under toxic and side effects, the Traditional Chinese medicine compound composition that untoward reaction is low.
Summary of the invention
Goal of the invention: the object of the invention is to overcome the deficiencies in the prior art, a kind of raw material that adopts integration of edible and medicinal herbs is provided, proportioning is scientific and reasonable, has the curative effect of good blood fat reducing, and toxic and side effects is little, the Traditional Chinese medicine compound composition of clinical drug safety.Another object of the present invention is to provide the application of this Traditional Chinese medicine compound composition in the anti-curing hyperlipemia medicine of preparation.
Technical scheme: in order to realize above object, the technical scheme that the present invention takes is:
Have a Traditional Chinese medicine compound composition for blood fat reducing function, it is to be made up of the raw material of following portions by weight:
0.5～2 part of Folium Ginkgo extract, 45～180 parts, Folium Nelumbinis, 3～12 parts of Folium Eucommiaes, 3～12 parts of Herba Portulacaes, 45～180 parts of Herb Gynostemmae Pentaphylli, 50～200 parts of Fructus Crataegis, 45～180 parts, Rhizoma Curcumae Longae, 15～60 parts of Semen Ziziphi Spinosaes.
As preferred scheme, the above-described Traditional Chinese medicine compound composition with blood fat reducing function, it is to be made up of the raw material of following portions by weight:
0.5～1 part of Folium Ginkgo extract, 45～90 parts, Folium Nelumbinis, 3～6 parts of Folium Eucommiaes, 3～6 parts of Herba Portulacaes, 45～90 parts of Herb Gynostemmae Pentaphylli, 50～100 parts of Fructus Crataegis, 45～90 parts, Rhizoma Curcumae Longae, 15～30 parts of Semen Ziziphi Spinosaes.
As the scheme being more preferably, the above-described Traditional Chinese medicine compound composition with blood fat reducing function, it is to be made up of the raw material of following portions by weight:
0.5 part of Folium Ginkgo extract, 45 parts, Folium Nelumbinis, 3 parts of Folium Eucommiaes, 3 parts of Herba Portulacaes, 45 parts of Herb Gynostemmae Pentaphylli, 50 parts of Fructus Crataegis, 45 parts, Rhizoma Curcumae Longae, 15 parts of Semen Ziziphi Spinosaes.
The Traditional Chinese medicine compound composition with blood fat reducing function of the present invention, described Folium Ginkgo extract is prepared by following method: get Folium Ginkgo and suitably pulverize, add 8 to 12 times of amount 70% alcohol reflux 1～3 time, each 1～1.5 hour, merge extractive liquid, filter, decompression recycling ethanol, add suitable quantity of water to leach, leave standstill, filter, upper AB-8 or the absorption of D-101 resin column, after washing clarification, use 95% ethanol elution, collect eluent, concentrating under reduced pressure, upper polyamide column, first wash with water, use again 70% methanol-eluted fractions, collect 70% meoh eluate, concentrating under reduced pressure, drying under reduced pressure and get final product.
The Traditional Chinese medicine compound composition with blood fat reducing function of the present invention, is prepared into this Traditional Chinese medicine compound composition and pharmaceutically acceptable carrier the medicine of oral liquid, capsule, tablet, granule, drop pill or encapsulated form.
Traditional Chinese medicine compound composition provided by the invention Traditional Chinese medicine compound composition and carrier lactose or corn starch, adds magnesium stearate lubricant in the time making tablet while needs, mix homogeneously, and then tabletting is made tablet.
When Traditional Chinese medicine compound composition provided by the invention is made capsule, Traditional Chinese medicine compound composition and carrier lactose or corn starch mix homogeneously, granulate, the then encapsulated capsule of making.
When Chinese medicine composition granulation agent provided by the invention, Chinese medicine composition and diluent lactose or corn starch mix homogeneously, granulate, dry, granulation agent.
Traditional Chinese medicine compound composition provided by the invention has good by effect of blood fat, can be used for preparing Cardiovarscular, as the application in atheromatosis or hyperlipidemia medicine or health product.
The present invention is under the guidance of Chinese medical theory, and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, in conjunction with pathogeny and the disease symptom of hyperlipemia; screening prescription; sweet, the bitter in the mouth, puckery, flat of Folium Ginkgo in side, GUIXIN, lung meridian, the ginkgetin in Folium Ginkgo has protection cardiovascular, improves microcirculatory effect.There is the hyperlipidemia rats of reduction serum cholesterol, triglyceride, high density lipoprotein increasing cholesterol levels.Folium Nelumbinis, Compendium of Material Medica is called its " hair growth promoting vigour, benefit helps taste, arresting seminal emission is turbid, scattered silt blood is separated burning hot ", " Folium Nelumbinis takes it, makes us thin bad, single clothes can disappear the gas of YANG edema edema ".Cortex Eucommiae tradition is used as medicine with skin, but bark growth cycle is very long, the effective ingredient of Folium Eucommiae and Cortex Eucommiae is basic identical, and Folium Eucommiae can make serum cholesterol, triglyceride obviously reduce, FFA, ALT, AST obviously reduce simultaneously, and liver fat degeneration and inflammatory reaction obviously alleviate.Herba Portulacae, records according to ancient medicine monograph: all herbal medicine, cold in nature, sour in the mouth, nontoxic.There is heat clearing away, removing toxic substances, QI invigorating, intestine moistening, loose blood, detumescence, dysentery relieving, prevent various diseases effect.Herba Portulacae contains in general Lu Sheng vegetable and does not contain, the omega-fatty acid that only has flesh of fish apoplexy due to endogenous wind just to contain.Omega-fatty acid has the function of blood fat reducing, can prevent and reduce hyperlipidemia, prevents platelet aggregation; Can suppress the generation of cholesterol and triglyceride, thereby reduce the content of neutral fat and cholesterol in blood, atherosclerosis, delay thrombosis.Herb Gynostemmae Pentaphylli contains multiple Ginsenosides, and wherein 4 saponin and ginsenoside Rb1, Rb3, Rd, F2 are same materials, are described as " the second Radix Ginseng ", there is the platelet aggregation of preventing, atherosclerosis, guarantees that blood flow is unobstructed, reduces effect of cardiovascular and cerebrovascular vessel sickness rate.The acid of Fructus Crataegi property, sweet, taste temperature, return spleen, stomach, Liver Channel, has effect of promoting digestion and removing stagnation, blood circulation promoting and blood stasis dispelling.Fructus Crataegi extract has good lipid-lowering effect.Rhizoma Curcumae Longae nature and flavor acrid, bitter, warm, GUIXIN, spleen, Liver Channel, have removing blood stasis, circulation of qi promoting, stimulate the menstrual flow, effect of pain relieving.Semen Ziziphi Spinosae sweet in the mouth, property is flat, has mind tranquilizing and the heart calming, arresting sweating, nourishing the liver function.All medicines share and complement each other, and have good adjusting blood fat, recover blood vessel elasticity, prevent effect of cardiovascular disease.
The preparation method of Traditional Chinese medicine compound composition provided by the invention is:
Get by weight Folium Nelumbinis, Folium Eucommiae, Herba Portulacae, Herb Gynostemmae Pentaphylli, Fructus Crataegi, Rhizoma Curcumae Longae and Semen Ziziphi Spinosae, add the water of 6 to 15 times of amounts of Chinese crude drug or ethanol extraction that concentration is 30～60% 1 to 3 time, and each 1 to 3 hour, merge extractive liquid,, concentrated, obtain extract.
The preparation method of Folium Ginkgo extract is suitably pulverized for getting Folium Ginkgo, adds 8 to 12 times of amount 70% alcohol reflux 1～3 time, and each 1～1.5 hour, merge extractive liquid,, filter, decompression recycling ethanol, adds suitable quantity of water to leach, and leaves standstill, filter, upper AB-8 or the absorption of D-101 resin column, after washing clarification, use 95% ethanol elution, collect eluent, concentrating under reduced pressure, upper polyamide column, first washes with water, then uses 70% methanol-eluted fractions, collect 70% meoh eluate, concentrating under reduced pressure, drying under reduced pressure and get final product.
Beneficial effect: compared to the prior art Traditional Chinese medicine compound composition provided by the invention has the following advantages:
The present invention, under the guidance of Chinese medical theory, adopts determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, in conjunction with pathogeny and the disease symptom of hyperlipemia, screening prescription, whole compositions proportioning is scientific and reasonable, and experimental result shows, Traditional Chinese medicine compound composition provided by the invention, there is effect of good blood fat reducing, can prevent and treat atherosclerosis, prevention and cure of cardiovascular disease, and the raw material that in compositions, each flavour of a drug are integration of edible and medicinal herbs, good effect, toxic and side effects is low, and clinical application is safer.
Traditional Chinese medicine compound composition provided by the invention can be prepared into the medicine of various dosage forms easily with pharmaceutically acceptable carrier, clinical application is convenient.
The specific embodiment
According to following embodiment, the present invention may be better understood.But, those skilled in the art will readily understand, the described concrete material proportion of embodiment, process conditions and result thereof be only for the present invention is described, and should also can not limit the present invention described in detail in claims.
Embodiment 1
1, have a Traditional Chinese medicine compound composition for blood fat reducing function, it is to be made up of the raw material of following portions by weight:
0.5 part of Folium Ginkgo extract, 45 parts, Folium Nelumbinis, 3 parts of Folium Eucommiaes, 3 parts of Herba Portulacaes, 45 parts of Herb Gynostemmae Pentaphylli, 50 parts of Fructus Crataegis, 45 parts, Rhizoma Curcumae Longae, 15 parts of Semen Ziziphi Spinosaes.
Described Folium Ginkgo extract prepares by the following method: gets Folium Ginkgo and suitably pulverizes, add 8 times of amount 70% alcohol reflux 3 times, and each 1.5 hours, merge extractive liquid,, filter, decompression recycling ethanol, adds suitable quantity of water to leach, and leaves standstill, filter, upper AB-8 resin column absorption, after washing clarification, use 95% ethanol elution, collect eluent, concentrating under reduced pressure, upper polyamide column, first washes with water, then uses 70% methanol-eluted fractions, collect 70% meoh eluate, concentrating under reduced pressure, drying under reduced pressure and get final product.
2, get 45 parts, Folium Nelumbinis, 3 parts of Folium Eucommiaes, 3 parts of Herba Portulacaes, 45 parts of Herb Gynostemmae Pentaphylli, 50 parts of Fructus Crataegis, 45 parts, Rhizoma Curcumae Longae, 15 parts of Semen Ziziphi Spinosaes, add 8 times of amounts, the ethanol extraction that concentration is 50% 2 times, each 2 hours, merge extractive liquid,, concentrated, obtain 1 part of extract and Folium Ginkgo extract and both mixed.
Embodiment 2
1, have a Traditional Chinese medicine compound composition for blood fat reducing function, it is to be made up of the raw material of following portions by weight:
1 part of Folium Ginkgo extract, 90 parts, Folium Nelumbinis, 6 parts of Folium Eucommiaes, 6 parts of Herba Portulacaes, 90 parts of Herb Gynostemmae Pentaphylli, 100 parts of Fructus Crataegis, 90 parts, Rhizoma Curcumae Longae, 30 parts of Semen Ziziphi Spinosaes.
Described Folium Ginkgo extract prepares by the following method: gets Folium Ginkgo and suitably pulverizes, add 12 times of amount 70% alcohol reflux 2 times, and each 1.5 hours, merge extractive liquid,, filter, decompression recycling ethanol, adds suitable quantity of water to leach, and leaves standstill, filter, upper D-101 resin column absorption, after washing clarification, use 95% ethanol elution, collect eluent, concentrating under reduced pressure, upper polyamide column, first washes with water, then uses 70% methanol-eluted fractions, collect 70% meoh eluate, concentrating under reduced pressure, drying under reduced pressure and get final product.
2, get 90 parts, Folium Nelumbinis, 6 parts of Folium Eucommiaes, 6 parts of Herba Portulacaes, 90 parts of Herb Gynostemmae Pentaphylli, 100 parts of Fructus Crataegis, 90 parts, Rhizoma Curcumae Longae, 30 parts of Semen Ziziphi Spinosaes, add 12 times of amounts, the ethanol extraction that concentration is 60% 3 times, each 2 hours, merge extractive liquid,, concentrated, obtain 1 part of extract and Folium Ginkgo extract and both mixed.
Embodiment 3
1, have a Traditional Chinese medicine compound composition for blood fat reducing function, it is to be made up of the raw material of following portions by weight:
2 parts of Folium Ginkgo extract, 180 parts, Folium Nelumbinis, 12 parts of Folium Eucommiaes, 12 parts of Herba Portulacaes, 180 parts of Herb Gynostemmae Pentaphylli, 200 parts of Fructus Crataegis, 180 parts, Rhizoma Curcumae Longae, 60 parts of Semen Ziziphi Spinosaes.
Described Folium Ginkgo extract prepares by the following method: gets Folium Ginkgo and suitably pulverizes, add 10 times of amount 70% alcohol reflux 1 time, and each 1.5 hours, merge extractive liquid,, filter, decompression recycling ethanol, adds suitable quantity of water to leach, and leaves standstill, filter, upper D-101 resin column absorption, after washing clarification, use 95% ethanol elution, collect eluent, concentrating under reduced pressure, upper polyamide column, first washes with water, then uses 70% methanol-eluted fractions, collect 70% meoh eluate, concentrating under reduced pressure, drying under reduced pressure and get final product.
2, get 180 parts, Folium Nelumbinis, 12 parts of Folium Eucommiaes, 12 parts of Herba Portulacaes, 180 parts of Herb Gynostemmae Pentaphylli, 200 parts of Fructus Crataegis, 180 parts, Rhizoma Curcumae Longae, 60 parts of Semen Ziziphi Spinosaes, to add 10 times of amount concentration be 50% ethanol extraction 2 times, each 3 hours, merge extractive liquid,, concentrated, obtain 1 part of extract and Folium Ginkgo extract and both mixed.
Embodiment 4 pharmacological evaluation
1. materials and methods
1.1 medicines and material
The Traditional Chinese medicine compound composition that embodiment 1 prepares.
High lipid food: add 20.0% sucrose, 15% Adeps Sus domestica, 1.2% cholesterol, 0.2% sodium cholate in feedstuff maintaining, appropriate casein, calcium hydrogen phosphate, stone powder etc.
1.2 instrument
Hitachi's 7100 type automatic clinical chemistry analyzers (751-0082)
TC test kit: Shanghai Foxing Changzheng medical science Co., Ltd, lot number: D1301033;
TG test kit: Shanghai Foxing Changzheng medical science Co., Ltd, lot number: D1307053
HDL test kit: Japanese Wako Pure Chemical Industries, Ltd., lot number: 998-09011
LDL test kit: Japanese Wako Pure Chemical Industries, Ltd., lot number: 993-39993
1.3 animals: male SD rat, body weight 180～200g, is provided by Beijing Vital River Experimental Animals Technology Co., Ltd., the quality certification number: SCXK(capital) 2012-0001.
1.4 raising conditions: rat is 20～24 ℃ in temperature, raises in the barrier system that humidity is 40%～60%, freely ingests, drinks water.
1.5 experimental techniques: 40 of male SD rats, are divided into 8 blanks by body weight, 32 models.Model group gave high lipid food after 2 weeks, blank and model group rat fasting blood sampling, be four groups by TC level by model components, be model control group, high dose group 8.29g/ (kgd), the middle dosage group 4.14g/ (kgd) of embodiment 1, low dose group 2.07g/ (kgd).After grouping, three dosage group gavages every day give the Traditional Chinese medicine compound composition that embodiment 1 prepares, and blank and model contrast give the CMC-Na solution of same volume simultaneously.Blank group maintains feedstuff simultaneously, and model contrast and three dosage groups give high lipid food.Administration is fasting blood sampling after 5 weeks, measures serum TC, TG, LDL-C, HDL-C level.
Date processing data result all with
represent.
2. experimental result
Specific experiment result is as shown in table 1.
Four measurement results of table 1 each group rat fat
Note: * and model group comparison, P<0.05; * and model group comparison, P<0.01.
Shown by above table 1 experimental result, normal group and model group comparison, TC, TG, LDL-C all have utmost point significant difference, therefore modeling success.There were significant differences in TC level for the low dose group of Traditional Chinese medicine compound composition provided by the invention, and LDL-C level has utmost point significant difference.And all there were significant differences in TC, TG, LDL-C level for middle and high dosage of the present invention, show that Traditional Chinese medicine compound composition provided by the invention has effect of good blood fat reducing, there is good prophylactic-therapeutic effect for the high atheromatosis causing of blood fat.And Traditional Chinese medicine compound composition raw material provided by the invention is integration of edible and medicinal herbs material, and toxic and side effects is low, and clinical application is safer, can be developed into the medicine into new blood fat reducing.
Above embodiment is only explanation technical conceive of the present invention and feature; its object is to allow person skilled in the art understand content of the present invention and implemented; can not limit the scope of the invention with this; all equivalences that spirit is done according to the present invention change or modify, and all should be encompassed in protection scope of the present invention.
Claims (8)
1. a Traditional Chinese medicine compound composition with blood fat reducing function, is characterized in that, it is to be made up of the raw material of following portions by weight:
0.5 ~ 2 part of Folium Ginkgo extract, 45 ~ 180 parts, Folium Nelumbinis, 3 ~ 12 parts of Folium Eucommiaes, 3 ~ 12 parts of Herba Portulacaes, 45 ~ 180 parts of Herb Gynostemmae Pentaphylli, 50 ~ 200 parts of Fructus Crataegis, 45 ~ 180 parts, Rhizoma Curcumae Longae, 15 ~ 60 parts of Semen Ziziphi Spinosaes.
2. the Traditional Chinese medicine compound composition with blood fat reducing function according to claim 1, is characterized in that, it is to be made up of the raw material of following portions by weight:
0.5 ~ 1 part of Folium Ginkgo extract, 45 ~ 90 parts, Folium Nelumbinis, 3 ~ 6 parts of Folium Eucommiaes, 3 ~ 6 parts of Herba Portulacaes, 45 ~ 90 parts of Herb Gynostemmae Pentaphylli, 50 ~ 100 parts of Fructus Crataegis, 45 ~ 90 parts, Rhizoma Curcumae Longae, 15 ~ 30 parts of Semen Ziziphi Spinosaes.
3. the Traditional Chinese medicine compound composition with blood fat reducing function according to claim 2, is characterized in that, it is to be made up of the raw material of following portions by weight:
0.5 part of Folium Ginkgo extract, 45 parts, Folium Nelumbinis, 3 parts of Folium Eucommiaes, 3 parts of Herba Portulacaes, 45 parts of Herb Gynostemmae Pentaphylli, 50 parts of Fructus Crataegis, 45 parts, Rhizoma Curcumae Longae, 15 parts of Semen Ziziphi Spinosaes.
4. according to claim 1, the Traditional Chinese medicine compound composition with blood fat reducing function described in 2 or 3, it is characterized in that, described Folium Ginkgo extract is prepared by following method: get Folium Ginkgo and suitably pulverize, add 8 to 12 times of amount 70% alcohol reflux 1 ~ 3 time, each 1 ~ 1.5 hour, merge extractive liquid, filter, decompression recycling ethanol, add suitable quantity of water to leach, leave standstill, filter, upper AB-8 or the absorption of D-101 resin column, after washing clarification, use 95% ethanol elution, collect eluent, concentrating under reduced pressure, upper polyamide column, first wash with water, use again 70% methanol-eluted fractions, collect 70% meoh eluate, concentrating under reduced pressure, drying under reduced pressure and get final product.
5. the Traditional Chinese medicine compound composition with blood fat reducing function according to claim 4, is characterized in that, this Traditional Chinese medicine compound composition and pharmaceutically acceptable carrier is prepared into the medicine of oral liquid, capsule, tablet, granule, drop pill or encapsulated form.
6. Traditional Chinese medicine compound composition claimed in claim 4 is in the application of preparing in Cardiovarscular medicine or health product.
7. the application of Traditional Chinese medicine compound composition claimed in claim 4 in preparation treatment atheromatosis medicine or health product.
8. the application of Traditional Chinese medicine compound composition claimed in claim 4 in preparation treatment hyperlipidemia medicine or health product.
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| CN108524782A (en) * | 2018-03-09 | 2018-09-14 | 黎兴科 | A kind of reducing blood lipid Tiny ecosystem Chinese medicine preparation and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104115974A (en) * | 2014-08-15 | 2014-10-29 | 吴江市德佐日用化学品有限公司 | Chinese herbal tea capable of clearing heat and removing dryness and preparation method thereof |
| CN108524782A (en) * | 2018-03-09 | 2018-09-14 | 黎兴科 | A kind of reducing blood lipid Tiny ecosystem Chinese medicine preparation and preparation method thereof |
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