CN101940621B - Chinese medicinal composition and preparation for relaxing bowel and preparation method thereof - Google Patents
Chinese medicinal composition and preparation for relaxing bowel and preparation method thereof Download PDFInfo
- Publication number
- CN101940621B CN101940621B CN2010105021580A CN201010502158A CN101940621B CN 101940621 B CN101940621 B CN 101940621B CN 2010105021580 A CN2010105021580 A CN 2010105021580A CN 201010502158 A CN201010502158 A CN 201010502158A CN 101940621 B CN101940621 B CN 101940621B
- Authority
- CN
- China
- Prior art keywords
- weight portion
- chinese medicine
- preparation
- composition
- loosening bowel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The invention relates to a Chinese medicinal composition for relaxing bowel. The composition is prepared from the following raw materials in part by weight: 10 to 25 parts of desertliving cistanche, 10 to 20 parts of radish seed, 10 to 20 parts of cassia seed and 10 to 25 parts of bighead atractylodes rhizome. The composition has the advantages of strict prescription, remarkable special effect, wide resource of raw materials and low cost. Because the prescription is simple, the quality control of the medicament is simple. The composition is prepared into the soft capsule formulation according to the characteristics of active ingredients and has accurate dosing; the contents can be very quickly absorbed by a human body in the form of liquid state after the capsules are disintegrated in vivo; and the soft capsules have the advantages of smooth surfaces, good mouthfeel and easy swallowing. The clinical primary pharmaceutical effect verifies that the composition has the advantages of definite therapeutic effect, rapid response, no toxic or side effect, safety, effectiveness, safe carrying and convenient eating for middle aged and elderly constipation patients. Clinical experiments verify that the effectiveness ratio reaches 100 percent and the composition has bright application prospect and market prospect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically a kind of loosening bowel to relieve constipation Chinese medicine composition at person in middle and old age's constipation patient, and the Chinese medicine preparation that utilizes said composition preparation the invention still further relates to the preparation method of this Chinese medicine preparation, belong to the field of Chinese medicines.
Background technology
Constipation is one of person in middle and old age's common frdquently encountered disease, and constipation in various degree can appear in many people with advancing age, brings very big harm for old people's physical and mental health.Sickness rate can reach 20-30%, and constipation is if can not get for a long time correcting, and intrarectal harmful substance can not in time be got rid of, and will produce harmful effect to human body.Constipation of old people can bring out and increase the weight of diseases such as angina pectoris, heart failure, emphysema, apoplexy, hemorrhoid, anal fissure, is one of factor of meeting accident of old people's cardiovascular and cerebrovascular disease, must attract great attention.
It is generally acknowledged, the reason of constipation, or Tianjin is hindered dryness of the intestine, is lost in making moist or intestinal obstructions, FU QI being obstructed or stagnation and deficiency of QI, large intestine conduction mistake department, so how clinical treatment rushes down internal organs, Fructus Cannabis class loosening bowel to relieve constipation with holding the gas heat clearing away.But these method of treatment improve in the recent period symptom still can, late result is person of modern times meaning not but, traces it to its cause, and belongs to the method for taking stopgap measures.Doctor trained in Western medicine is often selected lubricant, hyperosmotic laxative and Polyphenols medicine etc. for use.Many scholars do not advocate to use these cathartics, because of increasing the weight of constipation after the drug withdrawal, make old people's health weak more.
Therefore the medicine that has effect of relaxing bowel and have no side effect becomes the focus of those skilled in the art's research.
Summary of the invention
The objective of the invention is to propose a kind of effect of relaxing bowel that has, and raw material is simplified the easy Chinese medicine composition of preparation.
Another object of the present invention is to propose to utilize the Chinese medicine preparation of above-mentioned Chinese medicine composition preparation.
The 3rd purpose of the present invention is to propose the preparation method of above-mentioned Chinese medicine preparation.
Invention thinking of the present invention is: the inventor has proposed the unique preparation at senile constipation, Herba Cistanches sweet-salty in the Chinese medicine composition of the present invention through long term studies, warm in nature, function the kidney warming benefit is smart, warm waist intestine moistening, all medicines share, Synergistic treatment, but both the kidney warming benefit essence was effected a permanent cure, again can loosening bowel to relieve constipation to take stopgap measures, invigorating middle warmer has rushes down, liter is arranged in falling, have the compatibility characteristics of " residence leads among mending, and posts and falls within liter ".And compare with other medicines, the present invention has that composition is few, technology is simple, rapid-action, safe without toxic side effect, characteristics such as be convenient to take, and is the ideal medicament that is used for senile constipation.
The present invention selects Herba Cistanches, Semen Raphani, Semen Cassiae and the Rhizoma Atractylodis Macrocephalae, and four Chinese medicine makes up altogether, makes each medicine produce synergism these drug regimens, thereby can effectively play the effect of loosening bowel to relieve constipation.
The Herba Cistanches of wherein selecting for use: be the chylocaulous of the band scale leaf of orobanchaceae plant cistanche Cistanche deserticola Y.C.Ma..Main product in the Inner Mongol, ground such as Gansu, Xinjiang, Qinghai.Excavate when Seedling is not unearthed or just has been unearthed spring, removes inflorescence.Usefulness is given birth in section, or processed with wine is used.Its property of medicine is sweet, salty, temperature.Return kidney, large intestine channel.Has reinforcing the kidney and supporting YANG, the effect of loosening bowel to relieve constipation.Modern pharmacological research shows: Herba Cistanches can increase the enteral osmotic pressure, reduces the absorption of moisture, makes the stool deliquescing, and it can promote enterokinesia in addition, shortens defecation time.This explanation Herba Cistanches defecating feces excretion is different with other relieving constipation Chinese medicine such as Radix Et Rhizoma Rhei, Folium Sennae etc., is not to rush down down, but loosening bowel to relieve constipation makes stool become wet, deliquescing, is easy to discharge.So Herba Cistanches relieving constipation but wound body not are specially adapted to old people, puerpera and the valetudinarian of constipation, also are applicable to general crowd's constipation certainly.
Semen Raphani: be the mature seed of crucifer Radix Raphani Raphanus sativus L..All there is cultivation all parts of the country.Tap plant during fruit maturation summer, dries, and rubs seed, dries again.Give birth to and use or stir-fry usefulness, the time spent smashs to pieces.Semen Raphani property of medicine suffering, sweet, flat.Return lung, spleen, stomach warp.Having and helping digestion except that expanding the effect of lowering the adverse-rising QI to resolve phlegm.The Compendium of Material Medica record: the Semen Raphani effect has therapeutic method to keep the adverse QI flowing downwards Dingchuan, controls expectorant and helps digestion, and removes and expands sharp defecation; In addition, it contains and enriches oils and fats, and Replenishing QI and nourishing YIN is arranged, the merit of loosening bowel to relieve constipation, and the senile constipation cause of disease is the essence and blood degradation, and body fluid deficiency liquid is weary, and large intestine loses and moistens.The Semen Raphani (parched) circulation of qi promoting is regulated the flow of vital energy, and can make mechanism of qi fluent, just in time cuts the pathogenesis of senile constipation.The modern pharmacology effect shows: antibiotic in addition, eliminate the phlegm, antitussive, relieving asthma, improve urinary function and cholesterol reducing, prevent effects such as arteriosclerosis.
Semen Cassiae: be the dry mature seed of leguminous plant Semen Cassiae Cassia obtusifolia L. or little Semen Cassiae Cassia tora L..All there is cultivation north and south various places, the whole nation, main product in Anhui, ground such as Guangxi, Sichuan, Zhejiang, Guangdong, the mature fruit of gathering autumn is dried, and lays seed, removes impurity.Give birth to and use or fry usefulness.The Semen Cassiae property of medicine is sweet, bitter, salty, is slightly cold.Return liver, large intestine channel.Be used for the puckery pain of conjunctival congestion, it is dizzy to have a headache, constipation." the China's book on Chinese herbal medicine " that State Administration of Traditional Chinese Medicine's tissue is write, it is comparatively extensive to state its application, carries to say: " the liver heat removing kidney tonifying makes eye bright, the diuretic relieving constipation ".Modern pharmacological research shows, Semen Cassiae is except that containing saccharide, protein, fat, also contain steroidal compounds, chrysophanol, emodin etc., also have the trace elements iron, zinc, manganese, copper, nickel of needed by human etc., contained emodin, chrysophanic acid human body is had relieving asthma, function of gallbladder promoting, protect the liver, effects such as blood pressure lowering, defecation.
The Rhizoma Atractylodis Macrocephalae: be feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz. rhizome.Main product in Zhejiang, ground such as Hubei, Hunan.Gather winter, dries or dry, and removes fibrous root, cuts sheet, and life usefulness or parching with earth, parched with bran are used.The Rhizoma Atractylodis Macrocephalae property of medicine is sweet, bitter, warm.Return spleen, stomach warp.Has replenishing QI to invigorate the spleen, dampness diuretic, last antiperspirant, antiabortive effect.Modern pharmacological research shows: Rhizoma Atractylodis Macrocephalae decocting liquid has obvious promotion gastric emptying and intestinal propulsion function to mice.
The consumption of each drug component of the present invention also is that the inventor draws through groping in a large number to sum up, and each is organized consumption and all have better curative effect in the following weight parts ratio range.
The concrete technical scheme of the present invention is:
A kind of Chinese medicine composition of loosening bowel to relieve constipation, it is to be made by following raw materials in weight portion medicine:
Herba Cistanches 10-25 weight portion, Semen Raphani 10-20 weight portion, Semen Cassiae 10-20 weight portion, Rhizoma Atractylodis Macrocephalae 10-25 weight portion.
The Chinese medicine composition of above-mentioned a kind of loosening bowel to relieve constipation, preferable weight portion proportioning is:
Herba Cistanches 18-22 weight portion, Semen Raphani 15-18 weight portion, Semen Cassiae 15-18 weight portion, Rhizoma Atractylodis Macrocephalae 18-22 weight portion.
The Chinese medicine composition of above-mentioned a kind of loosening bowel to relieve constipation, best weight portion proportioning is:
Herba Cistanches 20 weight portions, Semen Raphani 15 weight portions, Semen Cassiae 15 weight portions, the Rhizoma Atractylodis Macrocephalae 20 weight portions.
A kind of Chinese medicine preparation of loosening bowel to relieve constipation, it is made up of above-mentioned Chinese medicine composition and pharmaceutics acceptable auxiliary.Can be according to known method in the pharmaceuticals industry, aforementioned pharmaceutical compositions is made various peroral dosage form after by the known method degerming.
According to the route of administration difference, Chinese medicine composition of the present invention is recommended to make oral formulations, as decoction, oral liquid, granule, tablet, sweet mastic, honeydew body or capsule etc.
The most preferred dosage form that the inventor recommends is a capsule, taking convenience, and have the characteristics of sustained-release administration, be more conducive to the absorption metabolism of pharmaceutical composition active component of the present invention.
Other three kinds of medical materials all contain fatty oil component except that Herba Cistanches, therefore the inventor has carried out fatty oil extraction research to other three kinds of medical material powder, and medicinal residues and Herba Cistanches after three kinds of medical material fatty oils are extracted have carried out the research that decocting extracts, to determine optimum extraction process, concrete processing step is as follows:
The preparation method of loosening bowel to relieve constipation Chinese medicine composition active component of the present invention, its concrete steps are as follows:
(1) the weight portion proportioning by claim 1 takes by weighing the Rhizoma Atractylodis Macrocephalae, Semen Cassiae and Semen Raphani, 10 times of alcohol reflux twice, and the time was respectively 1 hour and 2 hours;
(2) reflux extracting liquid of step (1) is added anhydrous sodium sulfate dehydration, standing over night, filter fatty oil, medicinal residues are standby;
(3) medicinal residues with step (2) add Herba Cistanches, and decocting extracts twice, and 1 hour for the first time, 2 hours for the second time, amount of water was 10 times of amounts, extracted twice gained medicinal liquid mixing concentrate drying, and it is standby to do medicated powder;
(4) the fatty oil mixing that obtains of dried medicated powder that step (3) is obtained and step (2) promptly makes the active component of Chinese medicine composition of the present invention.
The inventor has observed the influence of different ethanol concentration to the fatty oil extracted amount, and the concentration of alcohol that finally draws in the described step (1) is preferable at 40%-80% fatty oil extracted amount.Therefore concentration of alcohol is recommended to use the alcoholic solution of 80% concentration to carry out the extraction of fatty oil in 80% left and right sides fatty oil extracted amount the best.
The active component branch that method for preparing is gone out is packed into and is promptly made capsule, the 0.5g/ grain in the soft capsule.
The present invention also can adopt the conventional preparation method of the field of Chinese medicines to be prepared into other peroral dosage forms, as with crude drug grind into powder mix homogeneously, makes powder, uses mixing in water for oral taking.Raw material liquid medicine is carried, and the condensed water decocting liquid is made oral liquid.Also can concentrate and make clear paste, add adjuvant and make sweet mastic (soft extract) etc.
Usage of the present invention and consumption: the present invention is the oral way administration, every day three times, each two seed lac wafers.
Advantage of the present invention and benefit: the present invention write out a prescription the prescription rigorous, merit is specially imitated work, the crude drug wide material sources are with low cost.Because simplifying, prescription makes that drug quality control is simple.The present invention makes soft capsule dosage form according to its effective ingredient characteristics, and quantitatively accurately, after the disintegrate, content can be absorbed by health very soon with the form of liquid state in vivo, the soft capsule smooth surface, and mouthfeel is good, easily swallows.Through the checking of the drug effect of clinical principium, rapid-action, have no side effect especially at person in middle and old age's constipation patient determined curative effect, safe and effective and safe to carry, instant.The present invention reaches more than 90% through clinical experiment checking effective percentage, has good application prospects and market prospect.
The specific embodiment
The used medical material of present embodiment meets 2000 editions one ministerial standards of Pharmacopoeia of People's Republic of China all available from Chinese Medicinal Materials Co.
Pharmaceutical composition technical study of the present invention:
Get Rhizoma Atractylodis Macrocephalae 10g Semen Cassiae 20g Semen Raphani 20g reflux, extract, twice, be respectively 1 hour and 2 hours, the ethanol multiple is 10 times, has observed the influence of different ethanol concentration to the fatty oil extracted amount.The result is as follows:
Concentration of alcohol fat oil mass
40％ 16.5ml
60％ 21.0ml
80％ 31.0ml
Above result has repeated twice, show that it is feasible adopting the ethanol extraction fatty oil, but concentration of alcohol is bigger to the influence of fatty oil extracted amount.Therefore for fatty oil extracts fully, select for use 80% concentration of alcohol to extract fatty oil.
Reflux extracting liquid adds anhydrous sodium sulfate dehydration (the anhydrous sodium sulfate addition is advisable to reach maximum saturation).Standing over night, filter fatty oil, medicinal residues are standby.
Decocting extracts:
Three medicinal residues behind the ethanol extraction fatty oil add Herba Cistanches 10g decocting and extract 2 times, and 1 hour for the first time, 2 hours for the second time, amount of water was 10 times of amounts, extracted twice gained medicinal liquid concentrate drying, and it is standby to do medicated powder.It is as follows to extract the result three times:
Chinese crude drug amount dry extract amount
50g 12.1g
50g 13.2g
50g 11.7g
According to above technical study, we have determined that capsule extraction process of the present invention promptly at first adopts the fatty oil in the 80% alcohol reflux Rhizoma Atractylodis Macrocephalae, Semen Raphani and three kinds of medicines of Semen Cassiae, medicinal residues merge decocting with Herba Cistanches again and extract 2 times, the medicinal liquid concentrate drying, dried medicated powder and fatty oil mixing dress 0.5g/ grain soft capsule get final product, and concrete preparation method is as follows.
The preparation of embodiment 1 medicine capsule of the present invention
Crude drug and consumption:
Herba Cistanches 20g, Semen Raphani 15g, Semen Cassiae 15g, Rhizoma Atractylodis Macrocephalae 20g.
Preparation method:
(1) take by weighing each crude drug by above-mentioned consumption, at first with the Rhizoma Atractylodis Macrocephalae, Semen Cassiae and Semen Raphani, 10 times of alcohol reflux twice were respectively 1 hour and 2 hours.
(2) reflux extracting liquid with step (1) adds anhydrous sodium sulfate dehydration, and standing over night, filtration (80 mesh sieve) get fatty oil, and medicinal residues are standby;
(3) medicinal residues with step (2) add Herba Cistanches, and decocting extracts twice, and 1 hour for the first time, 2 hours for the second time, amount of water was 10 times of amounts, extracted twice gained medicinal liquid mixed atomizing drying, and it is standby to do medicated powder;
(4) the fatty oil mixing that obtains of dried medicated powder that step (3) is obtained and step (2) promptly makes the active component of Chinese medicine composition of the present invention;
(5) the active component branch is packed into promptly make soft capsule, the 0.5g/ grain in the soft capsule.
Embodiment 2 capsule preparations of the present invention
Crude drug and consumption:
Herba Cistanches 10g, Semen Raphani 20g, Semen Cassiae 20g, Rhizoma Atractylodis Macrocephalae 10g.
Preparation method:
(1) take by weighing each crude drug by above-mentioned consumption, at first with the Rhizoma Atractylodis Macrocephalae, Semen Cassiae and Semen Raphani, 10 times of alcohol reflux twice were respectively 1 hour and 2 hours.
(2) reflux extracting liquid with step (1) adds anhydrous sodium sulfate dehydration, and standing over night, filtration (80 mesh sieve) get fatty oil, and medicinal residues are standby;
(3) medicinal residues with step (2) add Herba Cistanches, and decocting extracts twice, and 1 hour for the first time, 2 hours for the second time, amount of water was 10 times of amounts, extracted twice gained medicinal liquid mixed atomizing drying, and it is standby to do medicated powder;
(4) the fatty oil mixing that obtains of dried medicated powder that step (3) is obtained and step (2) promptly makes the active component of Chinese medicine composition of the present invention;
(5) the active component branch is packed into promptly make soft capsule, the 0.5g/ grain in the soft capsule.
Embodiment 3 medicinal granule preparations of the present invention
Preparation method:
By following consumption weighting raw materials, crude drug of the present invention was soaked 20～30 minutes according to a conventional method, add 3 times of water gagings back that is fried boiling and kept fluidized state 10～15 minutes, taking liquid; Add 3 times of water gagings back that is fried boiling again and kept fluidized state 10～15 minutes, taking liquid; Twice medicinal liquid hybrid filtering is concentrated into relative density 1.3～1.34 thick pastes, spray granulation, drying.Packing.
Crude drug and consumption:
Herba Cistanches 25g, Semen Raphani 10g, Semen Cassiae 10g, Rhizoma Atractylodis Macrocephalae 25g.
Clinical experiment of the present invention and interpretation of result:
Case: select the constipation patient of age more than 55 years old; The course of disease is more than 1 year; Constipation with dry stool, the defecation effort; Intestinal fiberscope is got rid of colon, rectum quality sexually transmitted disease (STD) becomes.
The clinical experiment grouping: take the randomized controlled trial method, be divided into two groups, 55 examples are organized in treatment, matched group 50 examples.Treat preceding two groups of comparisons, all pass through statistical analysis, have comparability at aspects such as age, sex, the courses of disease.
Method: the contrast medicine is a MAREN RUANJIAONANG, each 2 times, and each 3.
The treatment group is with this Chinese medicine composition water decoction, every day 3 times, each 1 dose, 1 dose of 200ml.
Efficacy assessment standard: cure: defecation was 1 time in 2 days, and just matter is changeed profit, and unobstructed when separating, short-term does not have recurrence; Effectively: defecation was 1 time in 3 days, and just matter is changeed profit, and it is smooth that defecation is owed; Invalid: symptom does not have improvement.
Result: see Table 1
Table 1 liang group patient curative effect relatively
The Chinese medicine composition of above-mentioned clinical experiment presentation of results kidney loosening bowel to relieve constipation of the present invention is compared the curative effect with good loosening bowel to relieve constipation with matched group, total effective rate reaches 100%.
Claims (10)
1. the Chinese medicine composition of a loosening bowel to relieve constipation is characterized in that, it is to be made by following raw materials in weight portion medicine:
Herba Cistanches 10-25 weight portion, Semen Raphani 10-20 weight portion, Semen Cassiae 10-20 weight portion, Rhizoma Atractylodis Macrocephalae 10-25 weight portion.
2. the Chinese medicine composition of a kind of loosening bowel to relieve constipation according to claim 1 is characterized in that, it is to be made by following raw materials in weight portion medicine:
Herba Cistanches 18-22 weight portion, Semen Raphani 15-18 weight portion, Semen Cassiae 15-18 weight portion, Rhizoma Atractylodis Macrocephalae 18-22 weight portion.
3. the Chinese medicine composition of a kind of loosening bowel to relieve constipation according to claim 2 is characterized in that, it is to be made by following raw materials in weight portion medicine:
Herba Cistanches 20 weight portions, Semen Raphani 15 weight portions, Semen Cassiae 15 weight portions, the Rhizoma Atractylodis Macrocephalae 20 weight portions.
4. the Chinese medicine preparation of a loosening bowel to relieve constipation is characterized in that, is made up of the Chinese medicine composition and the pharmaceutics acceptable auxiliary of claim 1,2 or 3 described loosening bowel to relieve constipation.
5. the Chinese medicine preparation of a kind of loosening bowel to relieve constipation according to claim 4 is characterized in that, described dosage form is a peroral dosage form.
6. the Chinese medicine preparation of a kind of loosening bowel to relieve constipation according to claim 5 is characterized in that, described peroral dosage form is decoction, oral liquid, granule, tablet or capsule.
7. the preparation method of a loosening bowel to relieve constipation Chinese medicine composition active component is characterized in that, its concrete steps are as follows:
(1) the weight portion proportioning by claim 1 takes by weighing the Rhizoma Atractylodis Macrocephalae, Semen Cassiae and Semen Raphani, 10 times of alcohol reflux twice, and the time was respectively 1 hour and 2 hours;
(2) reflux extracting liquid of step (1) is added anhydrous sodium sulfate dehydration, standing over night, filter fatty oil, medicinal residues are standby;
(3) medicinal residues with step (2) add Herba Cistanches, and decocting extracts twice, and 1 hour for the first time, 2 hours for the second time, amount of water was 10 times of amounts, extracted twice gained medicinal liquid mixing concentrate drying, and it is standby to do medicated powder;
(4) the fatty oil mixing that obtains of dried medicated powder that step (3) is obtained and step (2) promptly makes the active component of Chinese medicine composition of the present invention.
8. preparation method according to claim 7 is characterized in that, the concentration of alcohol in the described step (1) is 40%-80%.
9. preparation method according to claim 8 is characterized in that, the concentration of alcohol in the described step (1) is 80%.
10. preparation method according to claim 9 is characterized in that, the active component branch of preparing is packed into and promptly made capsule in the soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105021580A CN101940621B (en) | 2010-05-28 | 2010-09-28 | Chinese medicinal composition and preparation for relaxing bowel and preparation method thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010185701A CN101837053A (en) | 2010-05-28 | 2010-05-28 | Chinese medicinal composition and preparation for loosening bowel and relieving constipation and preparation method thereof |
| CN201010185701.9 | 2010-05-28 | ||
| CN2010105021580A CN101940621B (en) | 2010-05-28 | 2010-09-28 | Chinese medicinal composition and preparation for relaxing bowel and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101940621A CN101940621A (en) | 2011-01-12 |
| CN101940621B true CN101940621B (en) | 2011-12-28 |
Family
ID=42740889
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010185701A Pending CN101837053A (en) | 2010-05-28 | 2010-05-28 | Chinese medicinal composition and preparation for loosening bowel and relieving constipation and preparation method thereof |
| CN2010105021580A Active CN101940621B (en) | 2010-05-28 | 2010-09-28 | Chinese medicinal composition and preparation for relaxing bowel and preparation method thereof |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010185701A Pending CN101837053A (en) | 2010-05-28 | 2010-05-28 | Chinese medicinal composition and preparation for loosening bowel and relieving constipation and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN101837053A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103385932B (en) * | 2013-07-08 | 2015-06-10 | 耿平 | Navel-compressing drug for preventing and curing constipation after malignant tumor chemotherapy |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102319342B (en) * | 2011-10-14 | 2013-04-10 | 贵州明湖药业股份有限公司 | Medicament for relaxing bowel and preparation method thereof |
| CN103417674B (en) * | 2013-07-16 | 2015-05-20 | 北京恒清堂医药科技有限公司 | Medicine composition for treating constipation and preparation method and specific uses thereof |
| CN105726944A (en) * | 2016-04-28 | 2016-07-06 | 刘兴忠 | Traditional Chinese medicine composition for treating constipation and preparing method thereof |
| CN109350660A (en) * | 2018-10-29 | 2019-02-19 | 何凤姣 | A kind of compound preparation of relax bowel and defecation and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943712A (en) * | 2005-10-08 | 2007-04-11 | 刘国飞 | A Chinese traditional medicinal composition for treatment of astriction and its preparation method |
| CN101015603A (en) * | 2007-02-01 | 2007-08-15 | 甘肃奇正藏药有限公司 | Medicine composition with fat-reducing and bowel relaxing functions, preparing process and quality controlling means thereof |
-
2010
- 2010-05-28 CN CN201010185701A patent/CN101837053A/en active Pending
- 2010-09-28 CN CN2010105021580A patent/CN101940621B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943712A (en) * | 2005-10-08 | 2007-04-11 | 刘国飞 | A Chinese traditional medicinal composition for treatment of astriction and its preparation method |
| CN101015603A (en) * | 2007-02-01 | 2007-08-15 | 甘肃奇正藏药有限公司 | Medicine composition with fat-reducing and bowel relaxing functions, preparing process and quality controlling means thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103385932B (en) * | 2013-07-08 | 2015-06-10 | 耿平 | Navel-compressing drug for preventing and curing constipation after malignant tumor chemotherapy |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101837053A (en) | 2010-09-22 |
| CN101940621A (en) | 2011-01-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103099959B (en) | Traditional Chinese medicine preparation for treating ulcerative colitis and preparation method thereof | |
| CN101797326B (en) | Chinese materia medica preparation for treating borborygmus diarrhoea and preparation method thereof | |
| CN101940621B (en) | Chinese medicinal composition and preparation for relaxing bowel and preparation method thereof | |
| CN101797301A (en) | Medicine for preventing and curing middle and old aged constipation | |
| CN102784221A (en) | Traditional Chinese medicine composition for treating constipation and preparation method and clinical preparation thereof | |
| CN107213227A (en) | It is a kind of to improve the Chinese medicine compound prescription and its product of constipation | |
| CN106215118A (en) | Antineoplastic health preparation and preparation method thereof | |
| CN104644967A (en) | Pharmaceutical composition for treating I-type diabetes and application thereof | |
| CN106994141B (en) | Traditional Chinese medicine composition for treating constipation and preparation method thereof | |
| CN105521332A (en) | Traditional Chinese medicinal composition for treating anal fissure, and preparation method and application thereof | |
| CN104983886A (en) | Traditional Chinese medicine preparation for treating constipation and preparing method thereof | |
| CN100488526C (en) | Oral preparation | |
| CN103463259A (en) | External use Chinese medicine bag for moving qi and relaxing bowel and preparation method thereof | |
| CN104173521B (en) | A kind of pharmaceutical composition and its preparation method giving birth to able-bodied sun | |
| CN114712466B (en) | Medicine with weight-reducing and beautifying effects and preparation method thereof | |
| CN114712470B (en) | Medicine for treating deficiency of kidney of men and preparation method thereof | |
| CN102218131A (en) | External Chinese herbal medicine composition for promoting tissue regeneration and knitting bones | |
| CN105920574A (en) | Palpitation treatment medicine and preparation method thereof | |
| CN105125693A (en) | Traditional Chinese medicine composition for treating acute gastritis and preparing method thereof | |
| CN104940739A (en) | Traditional Chinese medicine composition for biliary ascariasis treating | |
| CN104740396A (en) | Traditional Chinese medicine for treating kidney stones and preparation method of traditional Chinese medicine | |
| CN105311518A (en) | Medicine for treating asthma and preparation method thereof | |
| CN104606537A (en) | Qi-reinforcing and blood-nourishing medicated diet for improving chemotherapy-induced myocardial ischemic injury and preparation method | |
| CN105168774A (en) | Traditional Chinese medicine preparation for treating scapulohumeral periarthritis and preparation method thereof | |
| CN101380451B (en) | Preparation method of no-alcohol type Liusheng Qushu liquid oral preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: YANGTZE RIVER PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: GENERAL HOSPITAL OF CHINESE PLA Effective date: 20120416 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100853 HAIDIAN, BEIJING TO: 225321 TAIZHOU, JIANGSU PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20120416 Address after: 225321 No. 1 Jiangnan Rd Jiangnan high port district, Jiangsu, Taizhou Patentee after: Yangtze River Pharmaceutical Co., Ltd. Address before: 100853 Beijing Haidian District Fuxing Road No. 28 drug safety center Patentee before: General Hospital of Chinese PLA |