CN107213227A - It is a kind of to improve the Chinese medicine compound prescription and its product of constipation - Google Patents
It is a kind of to improve the Chinese medicine compound prescription and its product of constipation Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A61K36/42—Cucurbitaceae (Cucumber family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
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- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A61K9/282—Organic compounds, e.g. fats
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Abstract
The present invention improves the Chinese medicine compound prescription of constipation to be a kind of, includes the raw material composition of following parts by weight:1 part~30 parts of cassia seed, 1 part~20 parts of fructus cannabis, 1 part~20 parts of brush-cherry seed, 1 part~20 parts of radix bardanae, 1 part~20 parts of Momordica grosvenori, 1 part~20 parts of radix glycyrrhizae, wherein 1 part~20 parts of chrysanthemum, cassia seed, fructus cannabis, brush-cherry seed, radix bardanae, Momordica grosvenori are the Chinese medicine for having definite effect of relaxing bowel, mechanism of action is different, and fructus cannabis, brush-cherry seed are the Chinese medicine herbal pair that relaxes bowel, radix glycyrrhizae, chrysanthemum can be clearing heat and detoxicating, have auxiliary therapeutic action to constipation with heat retention.The Chinese medicine compound prescription is drafted in strict accordance with theory of traditional Chinese medical science, is constituted each medicine of prescription according to the principle compatibility of " monarch, minister, help, make ", can be reached " mutual reinforcement between ", the synergistic function of " mutually making ", therefore with good improvement anti-constipation effect.
Description
Technical field
The present invention relates to Chinese medicinal formulae field, and in particular to the Chinese medicine compound prescription of improvement constipation a kind of and uses this Chinese medicine compound prescription
What is be made has the product for improving constipation effect.
Background technology
Constipation refers to that the ill state of defecation that many reasons are caused, including excrement are dried discharge and do not done with excrement freely
Dry also two kinds of situations of difficult discharge, are the common symptons of disease of digestive system(And non-diseases), often cause people's mood change, vexed
Meaning is random, notice laxes, influence daily life and work, and can cause the multiple complications such as rectitis, intestinal obstruction, anal fissure, hemorrhoid.
Typically defecation still feels difficult defecation less than 2 times~3 times or 1 time a day weekly, being not clean to have some setbacks belongs to constipation.
Constipation pathogen and pathology of tcm is analyzed:
1st, stomach accumulated heat innate excess of YANG in the body, or after pyreticosis, waste heat is reluctant to leave, or the lung heat dryness of the lung, moves down large intestine, or overfeeding pure wine thickness
Taste, or overfeeding are pungent, or cross and take the medicine of a warm nature, can cause stomach accumulated heat, consumption hinders body fluid, enteron aisle is dry and astringent to lose profit, and excrement matter is dried, it is difficult to arranged
Go out, formed so-called " heat is secret ".
2nd, depression and stagnation of QI sorrow is pondered over, and spleen is felt frustrated knot;Or depressed angry, stagnation of QI due to depression of the liver;Or sitting is moved less, disorder of qi,
The internal organs obstruction of the circulation of vital energy can be caused stagnant, lead to that drop is not normal, conduction dereliction of duty stops in waste matter, must not be descending, or is intended to just not go out, or gone out without smooth, or
Dry and hard excrement forms " gas is secret ".
3rd, the stagnant addiction to uncooked and cold food of cold sensation of the genitalia, stagnate stomach and intestine;Or diseases caused by external factors cold-evil, straight middle stomach;Or take cold and cool excessively, tied in cold sensation of the genitalia,
Yin-cold excess, sluggish stomach and intestine can be caused, conduct not normal, waste matter is not all right, into " constipation due to endogenous cold ".
4th, deficiency of vital energy sun is declined improper diet and overtiredness, and taste are damaged;Or ferritic is weak, YANG QI deficiency;Or it is old, deficiency of vital energy sun declines;
Or prolonged illness postpartum, healthy tendency is multiple;Or eating cold and uncooked food excessively, damage yang-energy;Or bitter cold is sent an expedition against, impairment of yang gas consumption can cause deficiency of vital energy sun to decline,
Then large intestine conduction is powerless for the deficiency of vital energy, and then enteron aisle loses in warm the deficiency of yang, is tied in cold sensation of the genitalia, just under it is powerless, extend defecation time, formed just
It is secret.
5th, the deficiency of yin-fluid and blood ferritic deficiency of Yin;Body fluid deficiency blood is few;Or postpartum after being ill, the cloudy deficiency of blood is few;Or lose blood and take sweat by force, hinder Tianjin hemorrhage bleeding;
Or year is high weak, deficiency of YIN-blood;Or the pungent perfume of overfeeding is scorching, the cloudy blood of loss can cause deficiency of yin-fluid and blood, then large intestine is not flourish for the deficiency of blood,
Then large intestine is dry and astringent for yin deficiency, and enteron aisle loses profit, and dry and hard excrement is just lower difficult, into constipation.
Between above-mentioned various etiology and pathogenesis usually mutually and be disease, or mutually inversion of phases, such as stomach accumulated heat and depression and stagnation of QI can be with
And see, cold sensation of the genitalia is stagnant can be mutually simultaneous with deficient and weak YANG QI;With the passing of time depression and stagnation of QI changes heat, can cause thermojunction;With the passing of time thermojunction, consumes impairment of yin
Tianjin, can change into deficiency of Yin etc. again.However, constipation is always using actual situation as guiding principle, constipation due to endogenous cold, hot secret, gas are secret true, yang blood and qi deficiency institute
The empty secret then category of cause is empty.Can be converted between actual situation, can deficiency syndrome developing to excess syndrome, can sthenia symptoms caused by asthenia, and actual situation and see.It is summed up, shape
Basic pathogenesis into constipation is evil stagnant large intestine, and internal organs is gas-tight, and that the obstructed or intestines of plug lose is gentle, promotes powerless, causes large intestine conduction function to lose
Often.
Modern society, the incidence of disease of constipation is in rapid increase trend.The defaecation product of current clinical practice can be roughly divided into
Western medicine and Chinese medicine(Eaten including Chinese medicine, using Chinese medicine as the health food of raw material, using medicinal and edible Chinese medicine as the general function of raw material
Product)Two major classes.The direct symptomatic treatment of Western medicine, instant effect, but more have that side effect is larger, easily form dependence, easily lacking repeatedly etc.
Fall into.Treatment by Chinese herbs constipation is based on integrally-regulated, determined curative effect, though taking effect not as Western medicine rapidly, the property of medicine is gentle, with pair work
With it is small, be difficult to be formed dependence, be adapted to be used for a long time, it is safe and reliable the advantages of.Thus, in recent years declare tool effect of relaxing bowel or
The Chinese herbal product for improving constipation effect emerges successively.
In the prior art, patent No. ZL201210094257.9 Chinese patent literature discloses a kind of relax bowel
Chinese medicine and its product, the composition of the Chinese medicine is:It is 5 parts~50 parts of fructus cannabis, 5 parts~50 parts of cassia seed, 1 part~20 parts of radix polygonati officinalis, sweet
Careless 1 part~20 parts, 1 part~20 parts of Jasmine.The composition of the Chinese medicine that relaxes bowel is analyzed, the work(wherein real tool relaxes bowel
The only fructus cannabis and the taste medicine of cassia seed two of effect;Radix polygonati officinalis nourishing yin to moisten dryness, radix glycyrrhizae is clearing heat and detoxicating, coordinating the drug actions of a prescription, this two taste and fructus cannabis,
Cassia seed, which is shared, can play assistant and make;Jasmine does not have functions of loosening bowel relieving constipation in itself, analyzes and is also allowed to without assistant in terms of compatibility
Work(, it is actually dispensable.
The Chinese medicine compound prescription disclosed by the invention for improving constipation is by cassia seed, fructus cannabis, brush-cherry seed, radix bardanae, Momordica grosvenori, sweet
Grass, chrysanthemum are the definite ease constipation of tool by suitable proportioning composition, wherein cassia seed, fructus cannabis, brush-cherry seed, radix bardanae, Momordica grosvenori
The Chinese medicine of defaecation effect, mechanism of action is different, and fructus cannabis, brush-cherry seed are relax bowel Chinese medicine herbal pair, radix glycyrrhizae, chrysanthemum
Spending can be clearing heat and detoxicating, has auxiliary therapeutic action to constipation with heat retention.The Chinese medicine compound prescription is drafted in strict accordance with theory of traditional Chinese medical science, group
Each medicine into prescription can reach " mutual reinforcement between ", the synergistic function of " mutually making " according to the principle compatibility of " monarch, minister, help, make ",
Therefore with good improvement anti-constipation effect.
From the constituting of prescription, the mechanism of action of full side and the effect analysis to all types of constipation, improvement disclosed by the invention
The Chinese medicine compound prescription of constipation is compared with the Chinese medicine relaxed bowel disclosed in Chinese patent ZL201210094257.9 advantageously.
The Chinese medicine compound prescription disclosed by the invention for improving constipation is without " violent medicines " such as folium sennae, rheum officinales(Discharge function is excessively violent
It is strong, it is big to gastrointestinal irritability, often cause user uncomfortable, it is impossible to for a long time, largely to take, elderly and infirm, eipathia asthenia person, blood
Empty gas weak person, deficiency-cold in spleen and stomach person should disable or use with caution, and gynecologic menstrual, pregnancy period, nursing period should disable or use with caution), composition prescription
Each medicine is medicinal and edible Chinese medicine, and the property of medicine is gentle, and being reached by different mechanism of action improves the effect of constipation, more existing most of
Relax bowel, improve the Chinese herbal product of constipation(Contain folium sennae, rheum officinale composition mostly)Action temperature and, cause available for many reasons
Acute, chronic, habitual constipation, elderly and infirm, eipathia asthenia person, deficiency of blood gas weak person, deficiency-cold in spleen and stomach person be applicable, Fu Nvjing
Phase, pregnancy period, nursing period are applicable.
The content of the invention
In view of the shortcomings of the prior art, the present invention discloses a kind of Chinese medicine compound prescription of improvement constipation, and raw material is easy to get, preparation side
Just, acted on good improvement constipation, and action temperature and, be difficult to form dependence, available for constipation caused by many reasons.
To achieve these goals, the present invention discloses a kind of Chinese medicine compound prescription, includes the raw material composition of following parts by weight:
1~30 part of cassia seed, 1~20 part of fructus cannabis, 1~20 part of brush-cherry seed, 1~20 part of radix bardanae, 1~20 part of Momordica grosvenori is sweet
1~20 part of grass, 1~20 part of chrysanthemum.
The cassia seed is legume Cassia Cassia obtusifolia L.'s or little Cassia tora Cassia tora L.
Dry mature seed.Preferably, the parts by weight of the cassia seed are 1 part~10 parts;It is further preferable that the weight of the cassia seed
It is 6 parts~10 parts to measure number;Most preferably, the parts by weight of the cassia seed are 8 parts.
The fructus cannabis is moraceae plants hemp Cannabis sativa L. dry mature seed.Preferably, it is described
The parts by weight of fructus cannabis are 1 part~10 parts;It is further preferable that the parts by weight of the fructus cannabis are 1 part~3 parts;It is the most excellent
Selection of land, the parts by weight of the fructus cannabis are 2 parts.
The brush-cherry seed is rosaceous plant Europe Lee Prunus humilis Bge., strongly fragrant Lee Prunus japonica
Thunb., Amygdalus pedunculata Prunus pedunculata Maxim. dry mature seed.Preferably, the weight of the brush-cherry seed
It is 1 part~10 parts to measure number;It is further preferable that the parts by weight of the brush-cherry seed are 1 part~3 parts;Most preferably, described strongly fragrant
Li Ren parts by weight are 2 parts.
The radix bardanae is feverfew burdock Arctium lappa L. dry root.Preferably, the radix bardanae
Parts by weight are 1 part~10 parts;It is further preferable that the parts by weight of the radix bardanae are 1 part~5 parts;Most preferably, described
The parts by weight of radix bardanae are 3 parts.
The Momordica grosvenori is cucurbitaceous plant Momordica grosvenori Siraitia grosvenorii (Swingle) C.Jeffrey ex
A.M.Lu et Z.Y.Zhang dry fruit.Preferably, the parts by weight of the Momordica grosvenori are 1 part~10 parts;It is more highly preferred to
Ground, the parts by weight of the Momordica grosvenori are 1 part~5 parts;Most preferably, the parts by weight of the Momordica grosvenori are 3 parts.
The radix glycyrrhizae is glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix
Glycyrrhiza inflata Bta. or glycyrrhiza glabra Glycyrrhiza glabra L. dry root and rhizome.Preferably,
The parts by weight of the radix glycyrrhizae are 1 part~10 parts;It is further preferable that the parts by weight of the radix glycyrrhizae are 1 part~3 parts;It is the most excellent
Selection of land, the parts by weight of the radix glycyrrhizae are 2 parts.
The chrysanthemum is feverfew chrysanthemum Chrysanthemum molifolium Ramat. dry capitulum.It is excellent
Selection of land, the parts by weight of the chrysanthemum are 1 part~10 parts;It is further preferable that the parts by weight of the chrysanthemum are 2 parts~6 parts;Most
For preferably, the parts by weight of the chrysanthemum are 4 parts.
Invention additionally discloses a kind of decoction, herbal tea, decocted and be made as the starting material with water described in foregoing either a program.
Invention additionally discloses a kind of powder, pill, dripping pill, granule, tablet, hard capsule, soft capsule, soft extract,
Syrup, oral liquid, use solvent(Such as water or ethanol)Extract before the medicinal extract or crushing that the raw material described in foregoing either a program obtains
State the powder that the raw material described in either a program obtains and add auxiliary material and be made through corresponding technique.
Invention additionally discloses a kind of assembled alcoholic drinks, such as medicinal liquor, health liquor, alcoholic drink mixed with fruit juice, used as the raw material described in foregoing either a program
Soaking in Chinese liquor is made;Or be heated to reflux with ethanol, the medicinal extract that the raw material described in the foregoing either a program of seepage pressure effects is obtained add it is white
Wine allotment is made.
Invention additionally discloses a kind of alternative tea, as the raw material described in foregoing either a program it is size-reduced,(Water)Decoct, concentrate,
Granulation, dry, packaging are made.
Invention additionally discloses a kind of beverage, the medicinal extract obtained with the raw material described in foregoing either a program is boiled in decocting add water and
Auxiliary material is passed through to be made with liquid, sterilizing, packaging.
The Chinese medicine compound prescription disclosed by the invention for improving constipation is drafted in strict accordance with theory of traditional Chinese medical science:
Cassia seed:Monarch drug in a prescription.Heat-clearing improving eyesight, relaxes bowel.Its functions of loosening bowel relieving constipation eases up.Principle active component is Anthraquinones chemical combination
Thing.
Fructus cannabis:Ministerial drug.Relax bowel.To nourish the product of defaecation, effect is gentle, it is adaptable to old, physically weak and postpartum, disease
Afterwards because of dry constipation of intestines person caused by blood deficiency and depleted fluid.Intestinal mucosa can be stimulated, makes secretion increase, wriggle and accelerate, and reduce big intestinal absorption water
Point, therefore relax bowel.Principle active component is fat oil.
Brush-cherry seed:Ministerial drug.Relax bowel, lower gas Li Shui.For drop lets out lower gas and defaecation, it is adaptable to intestinal dryness caused by qi stagnation of large intestine
Constipation person, its defaecation effect is better than fructus cannabis, but without tonic effect.Principle active component is fat oil and prunuside.
Radix bardanae:Adjutant.Intestines peristalsis can be promoted, be conducive to stool to discharge.Principle active component is substantial amounts of solubility
Dietary fiber.
Momordica grosvenori:Adjutant.Clearing heat and moistening lung, relieving sore-throat opens sound, laxation defaecation.
Fructus cannabis, brush-cherry seed are the herbal pair of Chinese medicine of relaxing bowel, and are shared with cassia seed, radix bardanae, Momordica grosvenori, are risen
" mutual reinforcement between " is acted on, and can strengthen the effect that relaxes bowel.
Radix glycyrrhizae:Make medicine.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.
Chrysanthemum:Make medicine.Wind heat-clearing is dissipated, flat liver improving eyesight is clearing heat and detoxicating.
Radix glycyrrhizae, chrysanthemum can be clearing heat and detoxicating, waste heat after stomach accumulated heat innate excess of YANG in the body, pyreticosis are reluctant to leave, under the lung heat dryness of the lung
Move large intestine, overfeeding pure wine savoury, overfeeding are pungent, cross take medicine of a warm nature etc. caused by constipation with heat retention there is auxiliary therapeutic action.
The technical program uses and is used together radix glycyrrhizae and chrysanthemum in fructus cannabis, brush-cherry seed, cassia seed, radix bardanae, Momordica grosvenori,
Make drug effect gentleer, a variety of constitution crowds can be adapted to using the technique effect for reaching improvement constipation, and effect is gentle, no
Easily form dependence.
Full side's effect:Relax bowel.By different mechanism of action reach improve constipation effect, action temperature and, be difficult shape
Into dependence, available for acute caused by many reasons, chronic, habitual constipation.
Embodiment
In order that those skilled in the art more fully understands technical scheme, below by specific embodiment
The present invention is described in further detail.
It is disclosed by the invention to improve the Chinese medicine compound prescription of constipation, include the raw material of following parts by weight:
1 part~30 parts of cassia seed, 1 part~20 parts of fructus cannabis, 1 part~20 parts of brush-cherry seed, 1 part~20 parts of radix bardanae, 1 part of Momordica grosvenori
~20 parts, 1 part~20 parts of radix glycyrrhizae, 1 part~20 parts of chrysanthemum.
It is the decoction that is made up of above-mentioned raw materials through certain technique, powder, pill, dripping pill, granule, tablet, hard capsule, soft
Capsule, soft extract, syrup, tincture, oral liquid, assembled alcoholic drinks, alternative tea, herbal tea, beverage, solid beverage are respectively provided with good
Improve constipation effect, and action temperature and, basic reason is that the Chinese medicine compound prescription is drafted in strict accordance with theory of traditional Chinese medical science, constitute prescription
Each medicine property of medicine it is gentle, according to the principle compatibility of " monarch, minister, help, make ", " mutual reinforcement between " can be reached, the Synergistic of " mutually making " is made
With, therefore with good improvement anti-constipation effect.In addition, in order to improve conditioning effect, in the corresponding production of use above compound production
During product, the additives such as appropriate seasoning, toning, preservative are added, above compound is applicable multiple product, and can carry
The mouthfeel of taking using crowd is risen, interest is taken in raising, strengthens improvement.
Technical solution of the present invention is illustrated with specific embodiment below, but protection scope of the present invention is not by following examples
Limitation.
The alternative tea of the present invention of embodiment 1
Depend on 1 kilogram of pine torch, 1 kilogram of fructus cannabis, 1 kilogram of brush-cherry seed, 1.5 kilograms of radix bardanae, 1.5 kilograms of Momordica grosvenori, radix glycyrrhizae 1,000
Gram, 2 kilograms of chrysanthemum, net system;Fructus cannabis, brush-cherry seed, mangosteen powder are broken into coarse granule, merged with radix bardanae, radix glycyrrhizae, is added water pan-fried
Boil secondary, 8 times of amount water are added for the first time, soaks 0.5 hour, decocts 1 hour(Keep micro-boiling 1 hour), second plus 6 times of amount water,
Decoct 1 hour(Keep micro-boiling 1 hour), collecting decoction, filtration, it is 1.20 that filtrate, which is concentrated into relative density,(80 DEG C, heat is surveyed), obtain
Medicinal extract;Cassia seed, chrysanthemum are respectively crushed into coarse powder(Cross 18 mesh sieves), medicinal extract is added, is mixed, is dried 4 hours in 70 DEG C, whole grain
(Cross 16 mesh sieves), obtain particle;Particle is loaded into tea bag filter bag, per packed 6 grams, alternative tea is obtained.
The herbal tea of the present invention of embodiment 2
Depend on 5 grams of pine torch, 25 grams of fructus cannabis, 10 grams of brush-cherry seed, 40 grams of radix bardanae, 8 grams of Momordica grosvenori, 15 grams of radix glycyrrhizae, 10 grams of chrysanthemum,
Net system, plus 12 times of amount water soak 0.5 hour, decoct 1 hour(Keep micro-boiling 1 hour), filter, discard filter residue, obtain herbal tea.
The water-honeyed pill of the present invention of embodiment 3
Depend on 95 grams of pine torch, 50 grams of fructus cannabis, 25 grams of brush-cherry seed, 35 grams of radix bardanae, 15 grams of Momordica grosvenori, 70 grams of radix glycyrrhizae, chrysanthemum 30
Gram, net system is respectively crushed into powder(Cross 100 mesh sieves), mix, every 100 grams of powder 75 grams of refined honey plus appropriate water pill, in 75
DEG C dry 6 hours, obtain water-honeyed pill.
The health liquor of the present invention of embodiment 4
Depend on 140 grams of pine torch, 60 grams of fructus cannabis, 40 grams of brush-cherry seed, 20 grams of radix bardanae, 20 grams of Momordica grosvenori, 100 grams of radix glycyrrhizae, chrysanthemum
20 grams, net system is soaked 30 days, filtration discards filter residue, obtains health liquor with 53 degree of 4000 milliliters of white wine.
The tablet of the present invention of embodiment 5
Depend on 15 kilograms of pine torch, 10 kilograms of fructus cannabis, 20 kilograms of brush-cherry seed, 30 kilograms of radix bardanae, 5 kilograms of Momordica grosvenori, radix glycyrrhizae 20
Kilogram, 5 kilograms of chrysanthemum, net system;Fructus cannabis, brush-cherry seed, mangosteen powder are broken into coarse granule, with radix bardanae, radix glycyrrhizae, chrysanthemum is closed
And, plus 10 times amount water soak 0.5 hour, decoct 1 hour(Keep micro-boiling 1 hour), filter, filtrate is concentrated into relative density and is
1.20(80 DEG C, heat is surveyed), medicinal extract is obtained, 45 kilograms of medicinal dextrin is added, mixed, is dried 8 hours in 90 DEG C, is crushed(Cross 80 mesh sieves),
Get dry extract powder;Cassia seed powder is broken into powder(Cross 80 mesh sieves), dried cream powder is added, is mixed, it is 65% simple syrup to add concentration
In right amount, mix, granulation(16 mesh sieves), dried 4 hours in 70 DEG C, whole grain(Cross 14 mesh sieves), obtain particle;Particle is pressed into plain piece(Often
Piece weighs 0.5 gram), film coating obtains tablet.
The powder of the present invention of embodiment 6
Depend on 300 grams of pine torch, 100 grams of fructus cannabis, 80 grams of brush-cherry seed, 40 grams of radix bardanae, 50 grams of Momordica grosvenori, 30 grams of radix glycyrrhizae, chrysanthemum
20 grams, net system is respectively crushed into fine powder(Cross 120 mesh sieves), mix, load aluminum-plastic composite membrane bag, per packed 5 grams, obtain powder.
The oral liquid of the present invention of embodiment 7
Depend on 800 grams of pine torch, 150 grams of fructus cannabis, 80 grams of brush-cherry seed, 200 grams of radix bardanae, 50 grams of Momordica grosvenori, 120 grams of radix glycyrrhizae, chrysanthemum
100 grams are spent, net system adds water to cook secondary, first time plus 10 times of amount water, soaks 0.5 hour, decoct 1 hour(Keep micro-boiling 1 small
When), second plus 8 times of amount water are decocted 1 hour(Keep micro-boiling 1 hour), collecting decoction, filtration, filtrate is concentrated into relative density
For 1.08(80 DEG C, heat is surveyed), medicinal extract is obtained, 2000 milliliters of the simple syrup that concentration is 80% is added, stirs evenly, add water to 5000 milliliters, stir
It is even, stand, filter, sterilizing, embedding obtains oral liquid.
The hard shell capsules of the present invention of embodiment 8
Depend on 1 kilogram of pine torch, 2 kilograms of fructus cannabis, 0.5 kilogram of brush-cherry seed, 2.5 kilograms of radix bardanae, 1 kilogram of Momordica grosvenori, radix glycyrrhizae 0.5
Kilogram, 1.8 kilograms of chrysanthemum, net system, add water to cook it is secondary, for the first time plus 12 times amount water, soak 0.5 hour, decoct 1 hour(Protect
Hold micro-boiling 1 hour), second plus 10 times of amount water are decocted 1 hour(Keep micro-boiling 1 hour), collecting decoction, filtration, filtrate concentration
It is 1.15 to relative density(80 DEG C, heat is surveyed), medicinal extract is obtained, white sugar powder is added(Cross 80 mesh sieves)15 kilograms, mix, granulation(14
Mesh sieve), dried 5 hours in 65 DEG C, whole grain(Cross 12 mesh sieves), particle is obtained, particle is loaded into capsule shells, 0.5g is filled per capsule, is obtained firmly
Capsule.
The solid beverage of the present invention of embodiment 9
Depend on 3 kilograms of pine torch, 1.5 kilograms of fructus cannabis, 1 kilogram of brush-cherry seed, 2 kilograms of radix bardanae, 0.6 kilogram of Momordica grosvenori, radix glycyrrhizae 1,000
Gram, 1.2 kilograms of chrysanthemum, net system, add water to cook it is secondary, for the first time plus 10 times amount water, soak 0.5 hour, decoct 1 hour(Keep
Micro-boiling 1 hour), second plus 8 times of amount water are decocted 0.5 hour(Keep micro-boiling 0.5 hour), collecting decoction, filtration, filtrate is dense
It is 1.18 to be reduced to relative density(80 DEG C, heat is surveyed), medicinal extract is obtained, white granulated sugar is added(Cross 100 mesh sieves)25 kilograms, mix, granulation(14
Mesh sieve), dried 4 hours in 70 DEG C, whole grain(Cross 12 mesh sieves), particle is obtained, particle is loaded into aluminum-plastic composite membrane bag, per packed 10g, obtained
Solid beverage.
Alternative tea treatment 60 clinical observation on the therapeutic effect of constipation patient of the present invention of embodiment 10
1 case and method
1.1 case selection
Reference《New Chinese medicine treats the guideline of clinical investigations of constipation》Formulate.
Inclusive criteria:18~25 years old, meet the Western medicine diagnostic criteria of constipation, the hot secret, gas of Chinese medical discrimination category is secret, void is secret, cold
Secret person.
Exclusion standard:Confirm there is rectum, colon organic disease on inspection(Such as tumour, polyp of colon, intestinal tuberculosis, clone
Family name's disease etc.)Caused bowel narrow causer;Age under-18s or more than 75 years old person;Allergic constitution person;It is associated with severe cardiac, brain
Blood vessel, liver, kidney and the serious protopathy of hemopoietic system, insane;Gestation and women breast-feeding their children.
Exit standard:Those who are allergic to this drug;There is serious adverse reaction person;Patient is not resistant to this medicine;Not by regulation
Drug user;Patient(Or family members)It is uncooperative, it is impossible to complete according to plan, or arbitrarily change medicine person.
1.2 medicines, dosage and the course for the treatment of
Test medicine:Depend on 3.2 kilograms of pine torch, 0.8 kilogram of fructus cannabis, 0.8 kilogram of brush-cherry seed, 1.2 kilograms of radix bardanae, Momordica grosvenori
1.2 kilograms, 0.8 kilogram of radix glycyrrhizae, 1.6 kilograms of chrysanthemum, net system;Fructus cannabis, brush-cherry seed, mangosteen powder are broken into coarse granule, with ox
Burdock root, radix glycyrrhizae merge, and add water to cook secondary, first time plus 8 times of amount water, decoct 1 hour(Keep micro-boiling 1 hour), Jia 6 for the second time
Amount water, is decocted 1 hour again(Keep micro-boiling 1 hour), collecting decoction, filtration, it is 1.22 that filtrate, which is concentrated into relative density,(80 DEG C,
Heat is surveyed), obtain medicinal extract;Cassia seed, chrysanthemum are respectively crushed into coarse powder(Cross 18 mesh sieves), medicinal extract is added, is mixed, it is small to dry 4 in 70 DEG C
When, whole grain(Cross 16 mesh sieves), obtain particle;Particle is loaded into tea bag filter bag, per packed 6 grams, alternative tea is obtained.Orally, daily 4
Secondary, every 6 hours once, and 1 bag every time, boiling water is brewed, slightly cool to drink.
Control drug:MAREN RUNCHANG WAN, the production of Beijing TongrenTang Co., Ltd Tongrentang Pharmaceutical Factory.Authentication code:
Z11020159.Lot number:15015655.Specification:6 grams are weighed per ball.Orally, twice a day, once 1 ball, is chewed every time within every 12 hours
Take or swallow.
The course for the treatment of:It is 3 days.During medication, the medicine of other defaecations must not be used.
1.3 clinical indexes
Observe and record patient symptom, sign situation of change, before medication, be discontinued after check blood routine, routine urinalysis, stool routine examination,
Hepatic and renal function(ALT、BUN、Cr)And electrocardiogram.
1.4 the standard of curative effect evaluation
Clinical efficacy criterion reference《New Chinese medicine treats the guideline of clinical investigations of constipation》Formulate.
Clinical recovery:Stool is normal or recovers to level before disease.
It is effective:Constipation is obviously improved, and interval time and just matter are close to normally;Or the slightly dry and infrequent defecation time of defecating is 72
Within hour.
Effectively:The infrequent defecation time shortens 1 day or the just dry and hard improvement of matter.
It is invalid:Constipation is without improvement.
1.5 statistical analysis
Enumeration data Chi-square Test, measurement data is examined with t, and ranked data are analyzed with Ridit, counts soft using PEMS2.0
Part bag carries out data processing.
2 results
2.1 general clinical datas
Include case 60, wherein treatment group 30 altogether, control group 30, before two groups of treatments case source, sex, the age,
Severity extent and other general information are relatively respectively provided with comparativity, are shown in Table 1.
2.2 clinical efficacy
2.2.1 treatment group and control group comparitive study
The result of table 2 is shown:Two groups of comparitive studies are not statistically significant(P > 0.05).
2.2.2 safety detection
Safety detection result is shown:Test medicine is to the heart of patient, Liver and kidney function and blood, urine, stool routine examination without obvious shadow
Ring.
2.2.3 adverse reaction
Adverse reaction is not found in this clinical test.
3 conclusions
Test medicine has functions of loosening bowel relieving constipation, belongs to that hot secret, gas is secret, void is secret, constipation due to endogenous cold acute, chronic, habituation to Chinese medical discrimination
Constipation, can effectively improve constipation symptom.
The treatment group of table 1 is compared with the general clinical data of control group
Project | Treatment group | Control group | P |
Case | 30 | 30 | |
Sex(Male/female) | 10/20 | 14/16 | 0.29 |
Age(±S) | 55.63±13.56 | 49.43±12.99 | 0.076 |
The state of an illness(Gently/in/weight) | 6/16/8 | 12/14/4 | 0.067 |
Chinese medical discrimination(Secret/empty secret/constipation due to endogenous cold of hot secret/gas) | 10/11/7/2 | 8/12/6/4 | 0.53 |
The treatment group of table 2 and control group comparitive study
The present invention is described in detail above, the principle and embodiment of the present invention explained using specific case
State, the explanation of above example is only intended to the method and its core concept for helping to understand the present invention.It should be pointed out that for this skill
For the those of ordinary skill in art field, under the premise without departing from the principles of the invention, some change can also be carried out to the present invention
Enter and modify, these are improved and modification is also fallen into the protection domain of the claims in the present invention.
Claims (9)
1. a kind of improve the Chinese medicine compound prescription of constipation, it is characterised in that including following raw material:
1 part ~ 30 parts of cassia seed, 1 part ~ 20 parts of fructus cannabis, 1 part ~ 20 parts of brush-cherry seed, 1 part ~ 20 parts of radix bardanae, Momordica grosvenori 1 part ~ 20
Part, 1 part ~ 20 parts of radix glycyrrhizae, 1 part ~ 20 parts of chrysanthemum.
2. according to claim 1 improve the Chinese medicine compound prescription of constipation, it is characterised in that including following raw material:Cassia
1 part ~ 10 parts of son, 1 part ~ 10 parts of fructus cannabis, 1 part ~ 10 parts of brush-cherry seed, 1 part ~ 10 parts of radix bardanae, 1 part ~ 10 parts of Momordica grosvenori, radix glycyrrhizae 1
Part ~ 10 parts, 1 part ~ 10 parts of chrysanthemum.
3. according to claim 2 improve the Chinese medicine compound prescription of constipation, it is characterised in that including following raw material:Cassia
6 parts ~ 10 parts of son, 1 part ~ 3 parts of fructus cannabis, 1 part ~ 3 parts of brush-cherry seed, 1 part ~ 5 parts of radix bardanae, 1 part ~ 5 parts of Momordica grosvenori, radix glycyrrhizae 1 part ~ 3
Part, 2 parts ~ 6 parts of chrysanthemum.
4. according to claim 3 improve the Chinese medicine compound prescription of constipation, it is characterised in that including following raw material:Cassia
8 parts of son, 2 parts of fructus cannabis, 2 parts of brush-cherry seed, 3 parts of radix bardanae, 3 parts of Momordica grosvenori, 2 parts of radix glycyrrhizae, 4 parts of chrysanthemum.
5. a kind of improve the Chinese medicine compound prescription product of constipation, it is characterised in that it is as the raw material described in any one of claim 1 ~ 4
Obtained decoction or herbal tea are boiled with decocting.
6. it is a kind of improve constipation Chinese medicine compound prescription product, it is characterised in that its be with solvent extract claim 1 ~ 4 any one institute
The powder that the raw material described in medicinal extract or crushing any one of claim 1 ~ 4 that the raw material stated is obtained is obtained adds auxiliary material through corresponding work
It is powder made from skill, pill, dripping pill, granule, tablet, hard capsule, soft capsule, soft extract, syrup, oral liquid, solid
Body beverage.
7. a kind of improve the Chinese medicine compound prescription product of constipation, it is characterised in that it is assembled alcoholic drinks, by any one of claim 1 ~ 4 institute
The raw material stated is produced above with more than 50 degree soaking in Chinese liquor 20 days;Or the raw material described in extraction any one of claim 1 ~ 4 is obtained
Medicinal extract add Severalquestionsshouspiritsblendingandmeasuring spiritsblendingandmeasuring be made.
8. a kind of improve the Chinese medicine compound prescription product of constipation, it is characterised in that it is as the raw material described in any one of claim 1 ~ 4
Size-reduced, decocting is boiled, concentrated, pelletizing, drying, packing obtained alternative tea.
9. a kind of improve the Chinese medicine compound prescription product of constipation, it is characterised in that it is by boiling any one of claim 1 ~ 4 institute with decocting
The medicinal extract that the raw material stated is obtained adds water and auxiliary material is passed through with liquid, sterilizing, the obtained beverage of packaging.
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