CN102526526B

CN102526526B - Chinese medicine for treating periodontitis with deficiency of kidney 'Qi', and preparation method and administration mode of Chinese medicine

Info

Publication number: CN102526526B
Application number: CN201210028156.1A
Authority: CN
Inventors: 李玉芹
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-01-13
Filing date: 2012-01-13
Publication date: 2014-01-15
Anticipated expiration: 2032-01-13
Also published as: CN102526526A

Abstract

The invention provides a Chinese medicinal composition for treating periodontitis with the deficiency of kidney 'Qi', which comprises prepared rehmannia root, white paeony root, raspberry, glossy privet fruit, eclipta, cistanche deserticola, flastem milk vetch seed, magnetite, gypsum, reed rhizome, coptis chinensis, largehead atractylodesrhizome, rice bean, Chinese wax gourd peel and licorice. The invention has the advantages that: the Chinese medicinal composition for treating periodontitis has small side effects and good curative effects, does not have drug resistance, is low in cost, high in cure rate and easy to take.

Description

The Chinese medicine, preparation method and the administering mode that are used for the treatment of kidney-yin deficiency type periodontitis

Technical field

The present invention relates to technical field of Chinese medicines, relate in particular to a kind of Chinese medicine composition that is used for the treatment of kidney-yin deficiency type periodontitis.

Background technology

Periodontitis is one of modal oral pathology, it is a kind of chronic infectious disease of invading gingiva, periodontal ligament and alveolar bone, it has a strong impact on masticatory function, ability to speak health, the health of whole body even, is in causing, the main cause of old people and part adolescence loss of tooth.Data shows: the sickness rate of China adult periodontal inflammation is up to 50%～60%.And to there is the danger of heart infarction in the heart patient who suffers from periodontitis higher 2～3 times than the heart patient without periodontitis.Periodontitis and oral cavity bacterium, also can cause bacterial pneumonia, and in the whole world, therefore nearly 8.3 ten thousand people are taken away life every year.Because most people is not enough to the seriousness understanding of periodontal disease, therefore, this sick sickness rate continues to rise in recent years.

Periodontitis is the destructive disease of a kind of multifactorial inflammation, periodontal tissue, and periodontal tissue is the poor loss of tooth that finally causes of regeneration capacity after frontal resorption especially.The cause of disease of periodontitis has a lot of aspects, bacterium factors: from biological angle, dental pulp disease can be described as a kind of infectious disease, and antibacterial is the most important paathogenic factor of dental pulp disease; Physical factor has mechanical injury, acute tooth wound, chronic interlock wound, temperature and galvanism; Chemical factor is mainly from the disinfecting drug in nest hole, rebasing thing and charges; Idiopathic factor may be from absorbing or external tooth resorption in tooth.

Modern medicine thinks, the morbidity of periodontitis is due to local factor and systemic factor combined effect, and local factor is mainly the stimulating factors such as tartar, bad dummy, and systemic factor comprises heredity, spirit and some systemic diseases.Local factor can be brought out antibacterial delay and bacterial plaque is heaped, and strengthens the aggressivity of antibacterial; Systemic factor can affect and change the reaction of body to microorganism, reduces defence and the repair ability of periodontal tissue.Along with the enhancing of bacteria attack power and the reduction of periodontal tissue's defence reparation power, the normal ecological balance of periodontal tissue is broken, and periodontitis will occur.

Modern medicine is to take local system treatment as main to the treatment of periodontitis, and whole body defence treatment is auxiliary.At present the Western medicine medicine for the treatment of periodontitis has a lot, and most medicines can only relief of symptoms, can not eradicate, whole body therapeutic is applied antibiotic more, short term efficacy still can, but along with the prolongation of the state of an illness, the variation of general disease, the generation of the carelessness that doctors and patients coordinate and the factors such as enhancing of bacterial drug resistance, likely cause whole body defence repair ability further to decline, cause the recurrence of periodontitis and increase the weight of, and Western medicine exists drug price high, cure rate is low, and Western medicine has the shortcomings such as apparent side effect.

Chinese medicine periodontitis has a long history, and has accumulated the experience enriched, and forms complete theoretical system, has in some aspects the incomparable advantage of Western medicine, and it can improve body's immunity, improve the imperial condition of disease power of patients with periodontitis.But prove through clinical use, some Chinese Herbs are slow, and the course for the treatment of is long, the patient shorter to the course of disease, the state of an illness is lighter, curative effect still can, longer to the course of disease, the patient that the state of an illness is heavier, its curative effect is just obvious not.

Summary of the invention

Technical problem to be solved by this invention is, overcome the deficiency of existing treatment, utilize the traditional Chinese medicine of China, provide that a kind of side effect is little, good effect, cost is low, cure rate is high, have no drug resistance, the Chinese medicine composition of the treatment kidney-yin deficiency type periodontitis of taking convenience, can fundamentally treat kidney-yin deficiency type periodontitis.

In order to solve above-mentioned technology, ask, the invention provides a kind of Chinese medicine composition that is used for the treatment of kidney-yin deficiency type periodontitis, it comprises: Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Fructus Rubi, Fructus Ligustri Lucidi, Herba Ecliptae, Herba Cistanches, Semen Astragali Complanati, Magnetitum, Gypsum Fibrosum, Rhizoma Phragmitis, Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae, Semen Phaseoli, Exocarpium Benincasae and Radix Glycyrrhizae.

Wherein, the ratio of weight and number of each component in described Chinese medicine composition is, Radix Rehmanniae Preparata 12～18 weight portions, the Radix Paeoniae Alba 10～14 weight portions, Fructus Rubi 35～50 weight portions, Fructus Ligustri Lucidi 30～40 weight portions, Herba Ecliptae 27～35 weight portions, Herba Cistanches 19～25 weight portions, Semen Astragali Complanati 16～20 weight portions, Magnetitum 8～14 weight portions, Gypsum Fibrosum 15～20 weight portions, Rhizoma Phragmitis 10～15 weight portions, Rhizoma Coptidis 12～16 weight portions, the Rhizoma Atractylodis Macrocephalae 9～13 weight portions, Semen Phaseoli 8～12 weight portions, Exocarpium Benincasae 6～10 weight portions and Radix Glycyrrhizae 8～13 weight portions.

Wherein, the ratio of weight and number of each component in described Chinese medicine composition is, Radix Rehmanniae Preparata 15～18 weight portions, the Radix Paeoniae Alba 12～14 weight portions, Fructus Rubi 45～50 weight portions, Fructus Ligustri Lucidi 35～40 weight portions, Herba Ecliptae 30～35 weight portions, Herba Cistanches 22～25 weight portions, Semen Astragali Complanati 18～20 weight portions, Magnetitum 12～14 weight portions, Gypsum Fibrosum 17～20 weight portions, Rhizoma Phragmitis 12～15 weight portions, Rhizoma Coptidis 14～16 weight portions, the Rhizoma Atractylodis Macrocephalae 11～13 weight portions, Semen Phaseoli 10～12 weight portions, Exocarpium Benincasae 8～10 weight portions and Radix Glycyrrhizae 10～13 weight portions.

Wherein, the dosage form that is used for the treatment of endo-medicine in the Chinese medicine composition of kidney-yin deficiency type periodontitis described in can be refined pill, hydration pill, capsule, tablet, powder, gargarism or decoct for honey; The dosage form of external used medicine can be unguentum, pad pasting or spray.

For solving the problems of the technologies described above, the present invention also provides the preparation method of above-mentioned Chinese medicine composition, and when the dosage form of described Chinese medicine composition is decoct, its preparation method comprises the following steps:

A, described component is mixed in proportion, is ground into powder;

B, A step is obtained to powder add in cold water and soak 12 hours～18 hours, with slow fire boiling, decocting time is 2 hours～3 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 3～5 times of the powder quality that obtains of A step;

C, the filtering residue that B step filter is obtained add in cold water again, with slow fire boiling 2 hours～3 hours, filter and obtain the second filtrate, identical in the quality of the water adding and B step;

D, merge filtrate twice, obtain described decoct.

For solving the problems of the technologies described above, the present invention also provides the preparation method of above-mentioned Chinese medicine composition, and when the dosage form of described Chinese medicine composition is tablet, its preparation method comprises the following steps:

1, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Fructus Rubi, Fructus Ligustri Lucidi, Herba Ecliptae, Herba Cistanches and Semen Astragali Complanati are mixed in proportion, are ground into powder, use ethanol as solvent, dipping, adopts percolation (" Chinese Pharmacopoeia " version appendix I O in 2010) with the speed of 1～3ml per minute percolation slowly, collects the liquid of just filtering appropriate, preserve separately, till continuation percolation is light to percolate color, collect the continuous liquid of filtering, be concentrated into thick paste, add the liquid of just filtering, mix, standing, after clarifying, filter, obtain fluid extract;

2, Rhizoma Phragmitis, Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae, Semen Phaseoli, Exocarpium Benincasae and Radix Glycyrrhizae are mixed, decoct with water, filter, merging filtrate, filtrate is condensed into clear paste;

3, Magnetitum and Gypsum Fibrosum are mixed in proportion, pulverize and be screened into 50 order to 100 object fine powders;

4, described fluid extract is added in described clear paste, mix, after volatilization residual solvent, 50 order to 100 object fine powders are pulverized and be screened into drying under reduced pressure, to dried cream powder,, the Magnetitum and gypsum mixtures fine powder, starch and the dextrin that add subsequently the 3rd step to obtain, mix homogeneously, granulates, dry, tabletting, makes tablet.

For solving the problems of the technologies described above, the present invention also provides the preparation method of above-mentioned Chinese medicine composition, and when the dosage form of described Chinese medicine composition is capsule, its preparation method comprises the following steps:

A, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Fructus Rubi, Fructus Ligustri Lucidi, Herba Ecliptae, Herba Cistanches and Semen Astragali Complanati are mixed in proportion, be ground into powder, with ethanol as solvent, dipping, adopts percolation with the speed of 1～3ml per minute percolation slowly, collects the liquid of just filtering appropriate, preserve separately, till continuation percolation is light to percolate color, collect the continuous liquid of filtering, be concentrated into thick paste, add the liquid of just filtering, mix, standing, after clarifying, filter, obtain fluid extract, after volatilization residual solvent, 50 order to 100 object fine powders are pulverized and be screened into drying under reduced pressure, to dried cream powder;

B, Rhizoma Phragmitis, Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae, Semen Phaseoli, Exocarpium Benincasae and Radix Glycyrrhizae are mixed, decoct with water, filter, merging filtrate, filtrate is condensed into clear paste;

C, Magnetitum and Gypsum Fibrosum are mixed in proportion, pulverize and be screened into 50 order to 100 object fine powders;

Mixture fine powder and starch that d, the clear paste that b step is obtained, c step obtain mix, the ratio of the quality sum of the fine powder that the clear paste that the quality of described starch and described b step obtain, c step obtain is 0.1: 1～0.3: 1, carry out subsequently pelletization treatment, dried, obtain compound particles;

The compound particles obtaining in the fine powder of e, described dried cream powder that a step is obtained, d step mixes with magnesium stearate, and acquisition capsule 's content incapsulates described capsule 's content in housing, to obtain capsule.

For solving the problems of the technologies described above, the present invention also provides the preparation method of above-mentioned Chinese medicine composition, and when the dosage form of described Chinese medicine composition is powder, its preparation method comprises the following steps:

A, by described raw material water brush, wash clean, pull out and dry;

B, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Fructus Rubi, Fructus Ligustri Lucidi, Herba Ecliptae, Herba Cistanches, Semen Astragali Complanati are put into respectively to marmite fry into charcoal, with pulverizer, be ground into respectively smalls, sieve; Dried Magnetitum, Gypsum Fibrosum, Rhizoma Phragmitis, Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae, Semen Phaseoli, Exocarpium Benincasae and Radix Glycyrrhizae are sent into respectively and in microtome, be cut into flakelet, then send into pulverizer and be ground into smalls, sieve;

C, the fine powder after above-mentioned steps gained is sieved drop into mixing and blending machine and fully mix, and obtain powder, subsequently with bottle or packing box packing.

Solve the problems of the technologies described above, the present invention also provides the preparation method of above-mentioned Chinese medicine composition, and when the dosage form of described Chinese medicine composition is pad pasting, its preparation method comprises the following steps:

The first step, puts into respectively marmite by Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Fructus Rubi, Fructus Ligustri Lucidi, Herba Ecliptae, Herba Cistanches, Semen Astragali Complanati and fries into charcoal, with pulverizer, is ground into respectively smalls, sieves; Dried Magnetitum, Gypsum Fibrosum, Rhizoma Phragmitis, Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae, Semen Phaseoli, Exocarpium Benincasae and Radix Glycyrrhizae are sent into respectively and in microtome, be cut into flakelet, then send into pulverizer and be ground into smalls, sieve;

Second step, is ground into smalls with pulverizer respectively by biological adhesive and excipient, sieves respectively;

The 3rd step, by the first step material mix homogeneously that the material that obtains and second step sieve and obtain that sieves, is pressed into pad pasting.

For solving the problems of the technologies described above, it is oral or external application that the present invention also provides the administering mode of above-mentioned Chinese medicine composition.

Beneficial effect of the present invention:

With respect to the medicine that is used for the treatment of kidney-yin deficiency type periodontitis of the prior art, adopt this Chinese medicine composition to kidney-yin deficiency type periodontitis treatment have that side effect is little, good effect, the advantage such as cost is low, cure rate is high, have no drug resistance, taking convenience.

The specific embodiment

Theory of Chinese medical science thinks, periodontitis belongs to " gingival atrophy " category, and tooth being the surplus of the bone, by kidney is led, and is stomach channel of foot-Yang-ming institute network, therefore in close relations with stomach, kidney, excessiveness of stomach-fire and deficiency of the kidney void are its main mechanisms.After tooth is kidney, the network that gum is stomach, pathogenic heat Bu Zaowei Tianjin, must consume kidney liquid.The clean folding of tooth is moist and firm, the event of kidney qi abundance, the shape that body fluid is not hindered.Tooth is dry, is the wound of stomach-Yin.Tooth light is dry as stone, for positive heat in the interior very, the large wound of body fluid.Dry tooth, as dry bones, mostly is kidney yin exhaustion, and essence is due to upper honor.Tooth is sparse loosening, and tooth root exposes, mostly be suffer from a deficiency of the kidney or hyperactivity of deficient fire due to.

Periodontitis position is at gums, close with the Zang-Fu relationship such as stomach spleen kidney large intestine, and surfeit is pungent processs rich, excessive drinking surfeit or exhaustion due to sexual indulgence serious offense etc. and can cause in stomach-fire and steam, the tooth that the disappears gum that burns; Or deficiency of kidney-YIN, hyperactivity of deficient fire, burning gingiva and sending out is primary disease; Prolonged illness causes QI and blood deficiency, and tooth loses and to moisten fosterly, and tooth loses moist and sees that teeth are loosening, the diseases such as gingival atrophy.

Motherland's medical science to the treatment of periodontal disease be take clearing stomach through excess-fire or nourishing kidney-yin, asthenic fire is fallen as main, act on the thought of " in healthy energy deposits; heresy can not be done ", be conceived to whole adjusting, focus on contacting of local and whole body, the disease-resistant potential of performance human body self, imperial condition of disease power and the autoimmune function of raising body, pay attention to the Therapeutic Method of " strengthening the body resistance ", from treatment periodontal disease angle, make up and strengthened modern medicine to the deficiency periodontitis whole body therapeutic method.

Theoretical according to Chinese medical discrimination, the pathogenesis of periodontitis is mainly stomach internal organs accumulated heat, and positive naked light is vehement, damp and hot fumigating in upper and form gingival atrophy; Kidney unit is deficient, kidney governing bones, tooth being the surplus of the bone, deficiency of the kidney, can not on reach, tooth loses and to moisten fosterly, causes odontoseisis, gingival atrophy; Deficiency of qi and blood, gums loses supports, pathogenic factor invasion, visitor causes gingival hemorrhage, atrophy, root of the tooth to appear, become flexible between cog.So Chinese medical discrimination to the understanding of its cause of disease be summarized as that oral cavity is unclean, gastrointestinal accumulated heat, deficient qi and blood and kidney qi loss, being familiar with very early suffers from a deficiency of the kidney can cause periodontitis.In " General Treatise on the Cause and Symptoms of Diseases ", say " eventually, the institute of marrow is supported in the institute of tooth person kidney ".Qing Dynasty's Zhang Jingyue is thought " renal failure tooth is fallen, and the solid tooth of essence is hard " in Jing-Yue Complete Works.The prestige of Qing Dynasty's force claims " the lower toothache of supporting, belongs to brothers Yang Ming bis-warps more, the event of gastric heat hyperactivity of fire ".Periodontitis roughly can be divided into steaming type, kidney-yin deficiency type and QIXUELIANGXU type in stomach-fire accordingly, and adopt respectively different square medicines to treat.In stomach-fire, the main disease of steaming type is: onset is more anxious, and red swelling of gingiva oozes out with mild pain and a small amount of pus and blood sexual secretion, halitosis bitter taste, and desire for cold drinks, excessive thirst, upset in the stomach, yellowish urine, constipation, red tongue, yellow fur is thick, full and large pulse or sliding number.The main disease of kidney-yin deficiency type is: red and swollen atrophy that gingiva is slight, and frequent hemorrhage pyorrhea, and root of the tooth a surname reveal, odontoseisis, thirsty parched throat, dizziness and tinnitus, soreness of the waist and knees, feverish sensation in the palms and soles, sleeps poor, red tongue with little fur, thready and rapid pulse.The main disease of QIXUELIANGXU type is: gingival atrophy color is light white, and root of the tooth a surname is loosening grinningly, and crunching is aching and limp weak, and while brushing teeth sucking, gingiva is easily hemorrhage, pale complexion, shortness of breath and lassitude, dizziness and blurred vision, palpitation and insomnia, anorexia anorexia, tastelessness ， great loose stool is thin, pale tongue white and thin fur, deep-thready pulse.

According to the traditional Chinese medical science principle of taking stopgap measures, effect a permanent cure, with clinical manifestations syndrome, carry out differentiation of symptoms and signs for classification of syndrome Comprehensive Treatment, to dissimilar periodontitis, adopt different prescriptions to treat, can bring into play to greatest extent drug effect.Chinese medicine composition of the present invention is mainly right is that the treatment of the periodontitis of kidney-yin deficiency type is had to extraordinary curative effect, according to theory of Chinese medical science, the periodontitis of this type is more common in worn with age, plain body weakness, deficiency of kidney essence marrow is few, kidney storing essence is the congenital foundation, kidney essense consume, bone mistake is moistened foster, frontal resorption, and suffering from a deficiency of the kidney can not main bone event odontoseisis.Kidney unit virtual loss, deficiency of kidney yin, the bright gingiva of hyperactivity of deficient fire fire, bone marrow is hollow, and tooth mistake is moistened foster, red swelling of gingiva companion atrophy, root of the tooth neck a surname dew, pain.Treatment for the periodontitis of kidney-yin deficiency type should be principle with " enriching yin and nourishing kidney, beneficial smart teeth consolidating ".

Chinese medicine composition of the present invention comprises following component: Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Fructus Rubi, Fructus Ligustri Lucidi, Herba Ecliptae, Herba Cistanches, Semen Astragali Complanati, Magnetitum, Gypsum Fibrosum, Rhizoma Phragmitis, Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae, Semen Phaseoli, Exocarpium Benincasae and Radix Glycyrrhizae.

Radix Rehmanniae Preparata kidney tonifying, essence replenishing in side, Radix Paeoniae Alba easing the affected liver to relieve pain, suppressing liver-YANG, both share, nourishing YIN and benefiting blood is enriched blood, treatment blood deficiency is dizzy, Fructus Rubi, Fructus Ligustri Lucidi and Herba Ecliptae can be lost by liver and kidney tonifying the moon, the head loses foster dizzy tinnitus, Herba Cistanches and Semen Astragali Complanati kidney-replenishing, benefiting essence-blood, improve the immunocompetence of body, anti-inflammatory and antalgic, Magnetitum is for suppressing the hyperactive liver and subsiding YANG, having a dizzy spell of invigorating the liver and kidney deficiency, deafness and tinnitus, Gypsum Fibrosum and Rhizoma Phragmitis clearing away heat-fire, treat the mouthfeel dryness of the tongue of flaming up of stomach-fire, halitosis, the cards such as toothache, Rhizoma Coptidis is rushed down clearly excess-fire in stomach, Rhizoma Atractylodis Macrocephalae spleen reinforcing promoting the circulation of QI, dampness diuretic, Semen Phaseoli and Exocarpium Benincasae promoting diuresis to eliminate damp pathogen, be beneficial to detumescence, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.All medicine combinations of inner and outside, play enriching yin and nourishing kidney, the effect of beneficial smart teeth consolidating.

The pharmacology analysis of each component is as follows:

Radix Rehmanniae Preparata: have another name called Radix Rehmanniae Preparata, sweet in the mouth, slightly warm in nature, enters liver, kidney channel, has the YIN nourishing of enriching blood, and beneficial essence is filled out the effect of marrow, for blood deficiency and yellow complexion; Dizzy, cardiopalmus, insomnia, menoxenia, collapses more than; Hepatic and renal YIN deficiency, night sweat, sufficient knee joint pain, soreness of the waist and knees, Hiccough and deaf, the head is dim-sighted; Seminal emission sexual impotence; Infertility; Menoxenia; Metrostaxis; Early whitening of beard and hair; Quench one's thirst; Constipation; The cards such as dyspnea with rapid and short breath of suffering from a deficiency of the kidney, medicineization justice " there is a cloud: Radix Rehmanniae Preparata, mat wine cooks, and bitter in the mouthization is sweet, alternating temperature cool in nature, special messenger's liver is enriched blood.Bitter anxious because of liver, with sweet, delay it, the main temperature gallbladder of holding concurrently, can beneficial painstaking effort, more the kidney invigorating water.All internal injuries are not enough, and bitter will is a tax on one's mind, and suffering wound is clamored, the consumption of indulging in sensual pleasures essence, and regulating menstruation tire produces, and all should use this.Settling five organs, and blood vessels, profit skin, the punching of nourishing heart, peaceful soul, nourish Kidney-Yin, packing bone marrow, for panacea also, get its abnormal smells from the patient dense, be turbid product in turbid, to mend, stare at kidney, therefore all raw Radix Rehmanniaes Preparata are coveted.Radix Rehmanniae Preparata can promote anemia animal erythrocyte, hemoglobin to recover, and accelerates the propagation of hematopoietic stem cell, bone marrow hemopoietic progenitor cell of red blood cell line, differentiation.

The Radix Paeoniae Alba: bitter in the mouth, acid, cold nature, enters liver, spleen channel, the joint venture of nourishing blood, easing the affected liver to relieve pain, the effect of suppressing liver-YANG, is mainly used in headache feeling of fullness in the head, vertigo and tinnitus, the irritated irritability of deficiecny of liver-YIN, excessive rising of liver-YANG; Deficiency of liver-blood, battalion defends the menoxenia of inanition, metrorrhagia and metrostaxis; The dysmenorrhea of deficiency of the liver stasis dampness; Disharmony of nutrient QI with defensive QI, the cloudy outer inducing vomiting spontaneous sweating of battalion; The gastral cavity abdomen pain over the hypochondriac region of depression of liver-QI, dysentery stomachache; Deficiency and exhaustion of liver-YIN, passages through which vital energy circulates loses the cards such as carpopedal spasm pain of supporting, there is antithrombotic to form and hepatoprotective effect, dysentery bacterium, Bacillus typhi, blood dissolubility streptococcus, Diplococcus pneumoniae, bacillus pyocyaneus, staphylococcus aureus are had to inhibitory action, the Radix Paeoniae Alba and Radix Rehmanniae Preparata share, with nourishing YIN and benefiting blood, enrich blood, treat the dizzy card that waits of blood deficiency.

Fructus Rubi: sweet in the mouth, flat, enter liver, kidney channel, there is the effect of the liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight, be used for the treatment of impotence and premature ejaculation, emission and spermatorrhea, cold womb is infertile, and leukorrhagia is rare clearly, frequent micturition incontinence of urine, and blurred vision is dark, early whitening of beard and hair, " Bencao Jingshu ": Fructus Rubi, its main QI invigorating person, says beneficial vital essence also.Kidney storing essence, kidney improving inspiration by invigorating kidney-QI, vital essence is sufficient, and body, from light, is sent out in vain not also.The respectful main tonify deficiency of reviving is absolutely continuous, reinforcing YIN-essence Jianyang, smoothing skin, peace and internal organs.The main man's kidney-jing deficiency of Zhen Quan exhausts, impotence, woman's food have a son.Large cloudy main settling five organs, beneficial color, supports vital essence, long hair, strong will.All get its kidney tonifying and add essence, the adopted ear of sweet acid convergence.

Fructus Ligustri Lucidi: sweet in the mouth, hardship, be slightly cold, enter liver, kidney channel, there is strong liver kidney tonifying, the effect of clearing away heat to improve acuity of vision, is mainly used in treating hepatic and renal YIN deficiency, and the head loses foster dizzy tinnitus, the symptoms such as yin asthenia generating intrinsic heat.Fructus Ligustri Lucidi can promote leukocyte, strengthens the effect of immunologic function, and staphylococcus aureus, dysentery bacterium are had to stronger inhibitory action.Modern medicine study proves, Fructus Ligustri Lucidi includes ursolic acid, mannitol, glucose, fatty wet goods, has heart tonifying, diuresis and hepatoprotective effect, can make the leukopenia quantity causing because of chemotherapy raise, and staphylococcus aureus, escherichia coli are had to inhibitory action.

Herba Ecliptae: have another name called Herba Ecliptae, China ink grass, floods and droughts lotus, sweet in the mouth, acid, cold in nature, return liver, kidney channel, play liver and kidney tonifying, the effect of cooling blood for hemostasis, for having a dizzy spell due to the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Be suitable for the deficiency of YIN and have hot person, be used for the treatment of the haematemesis of accumulated heat in stomach, the symptoms such as the hemoptysis of injury of blood vessel of the lung by heat, Herba Ecliptae has inhibitory action to staphylococcus aureus, Bacillus typhi, Song's Shigella flexneri, bacillus pyocyaneus, obviously enhancing non-specific immunity and cellular immune function.

Herba Cistanches: sweet in the mouth, salty, warm in nature, enter kidney, large intestine channel, has kidney-replenishing, benefiting essence-blood, the effect of loosening bowel to relieve constipation, for kidney yang deficiency, the impotence and premature ejaculation of asthenia of essence and blood, sterility and infertility, soreness of waist and knee joint, Hiccough and deaf, frequent micturition urine number, suffer from a deficiency of the kidney dryness of the intestine and puerperal blood deficiency, the cards such as constipation of deficiency of body fluid after being ill, can strengthen body fluid and cellular immune function, strengthen mononuclear phagocyte phagocytic activity.

Semen Astragali Complanati: sweet in the mouth, warm in nature, enter liver, kidney channel, there is tonifying the kidney to consolidate the essence, the effect of liver-benefiting eye-brightening, for lumbago due to renal deficiency, impotence and seminal emission, frequent urination and enuresis, the cards such as dizziness and tinnitus and leukorrhagia stranguria with turbid discharge, have antiinflammatory, pain relieving, analgesic effect, can improve the non-specific and specific immune function of body.

Magnetitum: acrid in the mouth is salty, property is flat, enters kidney, liver, lung meridian, there is suppressing the hyperactive liver and subsiding YANG, the effect of relieving convulsion, the hearing-improing and eyesight improving of calming the nerves, helping inspiration to relieve asthma, for the having a dizzy spell of deficiency of the liver and kindey, blurring of vision, deafness and tinnitus, irritability, palpitation with fear, insomnia, failure of the kidney in receiving QI, upper QI rising in reverse order such as breathes heavily at the card, Magnetitum, " herbal classic " acrid in the mouth gas is cold nontoxic, and " not record ", Zhen Quan are salty slightly poisonous, large bright sweet puckery putting down, hide the salty temperature of device, modern its use in detail should be the medicine of pungent salty tepor, and Gan Hanfei also.Its main general arthralgia rheumatism, in podomere, pain, can not hold thing, washes sour person, all, due to wet three gas of wind and cold, and pathogenic wind is outstanding, wins also.The excessive last disease of wind, sends out in extremity, therefore arthrodynia of the extremities can not be held thing.Invasion of the body by blended pathogenic wind and dampness, for a long time from cremating, and washes acid also in joint skin.Leading can dispersing wind and cold, and temperature can be got round by bribery, thus main also.Salty is aquation, can relaxing the bowels with lubricant drugs softening the hard mass, the loose poison of pungent energy, the tepor heat extraction that can pass through, therefore lead large hot stuffy sensation with restlessness, and subduing inflammation.Scrofula neck core, laryngalgia person, due to attacking on sufficient positive, few deficiency of YIN fire less, the salty lower suction to enter Shen，Qi Xing town pendant, fire is returned unit and is bitterly certainly stopped also.Magnetitum can enter kidney, supports kidney.Kidney governing bones, therefore can bone strengthening.Kidney storing essence, therefore can benefit essence.Kidney opening at ear, therefore can treat deaf.Kidney master executes and lets out, and for a long time secret solid vital essence is full of benefit, and exoergic has made us sub-pediatric epilepsy scared, and the motive is timid, expectorant intenseness of heat also, salty can relaxing the bowels with lubricant drugs, mental disorder may be cured with heavy sedatives, is with master's.All YAOSHI are all poisonous, and should not take for a long time, solely Magnetitum report punching and, without violent brave gas, more have the merit of the kidney invigorating and essence nourishing, mostly steep wine, be better than ball, loose, the heavy Gu Er of stone gonosome.

Gypsum Fibrosum: acrid in the mouth, sweet, property Great Cold, enters lung, stomach warp, has clearing away heat-fire, an effect of the relieving restlessness of quenching the thirst, the all thin and matter weights of its abnormal smells from the patient, can removing summer-heat the excess-heat of stomach of foot Yang Ming, treatment pathogen invading YANG MING fill the air the symptoms such as high heat, profuse sweating, thirsty, vexed, arteries and veins is big vast, be the key medicine of the bright stomach warp of sun, Gypsum Fibrosum also can be used for the burning pain in the epigastrium due to the high Sheng of stomach-fire, headache, halitosis swelling of the gum, the cards such as aphtha of the mouth and tongue.

Rhizoma Phragmitis: sweet in the mouth, cold in nature, enter lung, stomach warp, there is lung heat clearing gastric heat, diuresis, dissipating depression of QI clearing away phlegm, the effect of YIN nourishing and the production of body fluid promoting, is mainly used in the dysphoria with smothery sensation that epidemic febrile disease heat joins the army minute thirsty, and dryness of the tongue Tianjin is few, pathogenic heat is violated lung to cough and expectoration, the cough vomiting pus of lung abscess, the damp and hot cards such as vomiting vomiting that block in stomach.

Gypsum Fibrosum rushes down positive bright stomach through excess-fire, and only, Papillary, treats the cards such as mouthfeel dryness of the tongue, halitosis, toothache of flaming up of stomach-fire for Rhizoma Phragmitis nourishing stomach-YIN and raw stomach.

Rhizoma Coptidis: bitter in the mouth, cold in nature, enter the heart, lung, gallbladder, stomach, large intestine channel, there is the effect of heat clearing and damp drying, eliminating fire and detoxication, cooling blood for improving eyesight, be longer than the fire of removing pathogen in the heart stomach, have the disappear merit of painful abdominal mass of preventing or arresting vomiting concurrently, can be used for treating the dysphoria and insomnia of heart-fire due to prosperous, and the high fever coma of epidemic febrile disease, vexed, thirsty; Also can be used for dysentery, tenesmus due to damp and hot; The cards such as pyretic toxicity carbuncle sore, eczema, aphtha of the mouth and tongue, epidemic hemorrhagic conjunctivitis, the effect that Rhizoma Coptidis has function of gallbladder promoting, expands little blood vessel, reduces blood pressure, and can strengthen leukocytic phagocytic activity, staphylococcus aureus, Hemolytic streptococcus, streptococcus pneumoniae, meningococcus, vibrio cholera, anthrax bacillus, dysentery bacterium are had to stronger bacteriostasis.

The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature, enter spleen, stomach warp, there is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect, for weakness of the spleen and stomach, lack of appetite distension, fatigue and weakness, have loose bowels, water-damp retention, phlegm retention, edema, the cards such as exterior deficiency spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae have adjust gastrointestinal motility function, antiulcer, protect the liver, the effect such as enhancing human body immunity function, anti-stress, enhancing hemopoietic function; Its dampness diuretic effect is relevant with diuresis; And antiabortive effect is relevant with the effect of inhibition uterine contraction.The Rhizoma Atractylodis Macrocephalae also has the effects such as antioxidation, slow down aging, blood sugar lowering, anticoagulation, antitumor.

Semen Phaseoli: sweet in the mouth, acid, property is flat, has the diuretic kind that disappears, the effect of removing toxic substances and promoting pus discharge, for cards such as edema distension, beriberi edema, jaundice dark coloured urine, rheumatism pyretic arthralgia, carbuncle sore tumefacting virus, abdominalgia with intestinal abscess, Compendium of Material Medica: Semen Phaseoli, its property is descending, logical small intestinal, can enter cloudy minute, controls tangible disease.Therefore promoting circulation of body fluid, diuresis, relieving distension is except swollen, emesis and to control the inferior dysentery intestinal out-of-the-way, and the disease of relieving the effect of alcohol, except cold and heat carbuncle, the loose blood of evacuation of pus and promoting lactation, lower afterbirth dystocia, all tangible person of disease.Clothes fall order too for a long time, and body fluid oozes to be let out, so make leanness heavy sensation of the body also.Its nasal insufflation Guadi San and ward off pestilence with it, also gets its ventilation dehumidifying heat radiation ear.

Exocarpium Benincasae: sweet in the mouth, cold nature, returns lung meridian, spleen channel, small intestine meridian, has the effect of clearing away heat and promoting diuresis, detumescence, cards such as being used for the treatment of edema, dysuria, having loose bowels, skin ulcer is swollen.

Radix Glycyrrhizae: property is flat, and sweet in the mouth, enters 12 warps, there is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription, for insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse and deficiency of spleen-QI and stomach-QI, fatigue and weakness, ulcer sores, laryngopharynx swelling and pain, asthma and cough, is in harmonious proportion the strong of some drugs, " explaining abstruseness of the canon of materia medica ": Radix Glycyrrhizae, sweet flat product, solely enter taste, Li Shizhen (1518-1593 A.D.) is said and can be passed into 12 through person, also non-.Sowing and reaping is done sweet, and the positive taste of soil, therefore Radix Glycyrrhizae is Middle Palace tonic." not Lu " cloud, the therapeutic method to keep the adverse QI flowing downwards is controlled full, Zhen Quanyun, except distention and fullness in the abdomen, lid spleen must be mended and be good at strong fortune also.If spleen soil is person too, wrongly take to turn and add distension, therefore say splenopathy people, polyphagia is not sweet, in Gan Nengman, this be native real person's speech also.Common customs are not distinguished deficiency and excess, often see distension, just prohibit Radix Glycyrrhizae, why not think very?

Further preferably, the Chinese medicine composition that is used for the treatment of kidney-yin deficiency type periodontitis described in only consists of said components.

In the described Chinese medicine composition that is used for the treatment of kidney-yin deficiency type periodontitis, the ratio of weight and number of various components can be preferably: Radix Rehmanniae Preparata 12～18 weight portions, the Radix Paeoniae Alba 10～14 weight portions, Fructus Rubi 35～50 weight portions, Fructus Ligustri Lucidi 30～40 weight portions, Herba Ecliptae 27～35 weight portions, Herba Cistanches 19～25 weight portions, Semen Astragali Complanati 16～20 weight portions, Magnetitum 8～14 weight portions, Gypsum Fibrosum 15～20 weight portions, Rhizoma Phragmitis 10～15 weight portions, Rhizoma Coptidis 12～16 weight portions, the Rhizoma Atractylodis Macrocephalae 9～13 weight portions, Semen Phaseoli 8～12 weight portions, Exocarpium Benincasae 6～10 weight portions and Radix Glycyrrhizae 8～13 weight portions.

In the described Chinese medicine composition that is used for the treatment of kidney-yin deficiency type periodontitis, the ratio of weight and number of various components also can be more preferably: Radix Rehmanniae Preparata 15～18 weight portions, the Radix Paeoniae Alba 12～14 weight portions, Fructus Rubi 45～50 weight portions, Fructus Ligustri Lucidi 35～40 weight portions, Herba Ecliptae 30～35 weight portions, Herba Cistanches 22～25 weight portions, Semen Astragali Complanati 18～20 weight portions, Magnetitum 12～14 weight portions, Gypsum Fibrosum 17～20 weight portions, Rhizoma Phragmitis 12～15 weight portions, Rhizoma Coptidis 14～16 weight portions, the Rhizoma Atractylodis Macrocephalae 11～13 weight portions, Semen Phaseoli 10～12 weight portions, Exocarpium Benincasae 8～10 weight portions and Radix Glycyrrhizae 10～13 weight portions.

In the described Chinese medicine composition that is used for the treatment of kidney-yin deficiency type periodontitis, the dosage form of endo-medicine can be: honey refining pill, hydration pill, capsule, tablet, powder, gargarism or decoct; The dosage form of external used medicine can be: unguentum, pad pasting or spray.

The described administering mode that is used for the treatment of the Chinese medicine composition of kidney-yin deficiency type periodontitis is oral, spraying or external application.

When the dosage form of Chinese medicine composition of the present invention is decoct, its preparation method comprises the following steps:

A, described component is mixed in proportion, is ground into powder;

D, merge filtrate twice, obtain described decoct.

In use, if taken with decoct, 3 doses of every days, the morning, noon and afternoon, respectively once every dose of decocting took described Chinese medicine composition at twice, and every 7 days is a course for the treatment of.

When the dosage form of Chinese medicine composition of the present invention is tablet, its preparation method comprises the following steps:

4, described fluid extract is added in described clear paste, mix, after volatilization residual solvent, drying under reduced pressure is to dried cream powder, be ground into 50 order to 100 object fine powders, the Magnetitum and gypsum mixtures fine powder, starch and the dextrin that add subsequently the 3rd step to obtain, mix homogeneously, granulates, dry, tabletting, makes tablet.

In described the 1st step, the amount of the ethanol adding is 3～5 times of quality of the mixture in the 1st step, dip time is 24h～48h, the quality of the first liquid of filtering of collecting is 85%～95% of the ethanol quality that adds, the quality that the liquid of just filtering is collected is 70%～80% of the ethanol quality that adds, and continuous relative density of filtering the concentrated thick paste forming of liquid is 1.22～1.24 (70 ℃).

The quality of the water adding in described the 2nd step is 4～6 times of mixture quality of the 2nd step, decocts three times, and each 1h～2h, filters respectively, and the relative density of the clear paste that filtrate is condensed into is 1.12～1.14 (70 ℃).

In described the 4th step, the starch adding and the mass ratio of dextrin are 4: 1～5: 1, and in the quality sum of the starch adding and dextrin and described Chinese medicine composition, the ratio of each constituent mass sum is 0.2: 1～0.4: 1.

In use, if with tablets, the specification of the tablet making is 0.3g/ sheet～0.5g/ sheet to described Chinese medicine composition, and every day 3 times, the morning, noon and afternoon, respectively once each 3, every 7 days was a course for the treatment of.

When the dosage form of Chinese medicine composition of the present invention is capsule, its preparation method comprises the following steps:

A, by Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Fructus Rubi, Fructus Ligustri Lucidi, Herba Ecliptae, Herba Cistanches and Semen Astragali Complanati are mixed in proportion, be ground into powder, with ethanol as solvent, dipping, adopt percolation (" Chinese Pharmacopoeia " version appendix I O in 2010) with the speed of 1～3ml per minute percolation slowly, collect the liquid of just filtering appropriate, preserve separately, till continuation percolation is light to percolate color, collect the continuous liquid of filtering, be concentrated into thick paste, add the liquid of just filtering, mix, standing, after clarifying, filter, obtain fluid extract, after volatilization residual solvent, drying under reduced pressure is to dried cream powder, pulverize and be screened into 50 order to 100 object fine powders,

In described a step, the amount of the ethanol adding is 3～5 times of quality of the mixture in a step, dip time is 24h～48h, the quality of the first liquid of filtering of collecting is 85%～95% of the ethanol quality that adds, the quality that the liquid of just filtering is collected is 70%～80% of the ethanol quality that adds, and continuous relative density of filtering the concentrated thick paste forming of liquid is 1.22～1.24 (70 ℃).

The quality of the water adding in described b step is 4～6 times of mixture quality of b step, decocts three times, and each 1h～2h, filters respectively, and the relative density of the clear paste that filtrate is condensed into is 1.12～1.14 (70 ℃).

In described e step, the ratio of the quality sum of the compound particles obtaining in the fine powder of the described dried cream powder that the quality of the magnesium stearate adding and a step obtain, d step is 0.15～100: 0.5～100.

In use, if taken with capsule, the specification of the capsule making is 0.25g/ grain～0.35g/ grain to described Chinese medicine composition, every day 3 times, the morning, noon and afternoon each once, each 3 capsules, every 7 days is a course for the treatment of.

When the dosage form of Chinese medicine composition of the present invention is powder, its preparation method comprises the following steps:

A, by described raw material water brush, wash clean, pull out and dry;

In described b step, the sieve used that sieves can be 50～100 orders, and the time of pulverizing in pulverizer can be 18～20 minutes.

In described c step, the sieve used that sieves can be 50～100 orders, and the time of pulverizing in pulverizer can be 18～20 minutes.

In use, if taken with powder, 3 doses of every days, the morning, noon and afternoon, respectively once every 7 days was a course for the treatment of to described Chinese medicine composition.

When the dosage form of Chinese medicine composition of the present invention is pad pasting, its preparation method comprises the following steps:

In the described first step and second step, the sieve used that sieves can be 50～100 orders, and the time of pulverizing in pulverizer can be 18～20 minutes.

The carbomer of the hydroxypropyl emthylcellulose that described biological adhesive comprises 10～70 % by weight and 1～40 % by weight.

The filler that is selected from monosaccharide, disaccharide, polysaccharide, starch and composition thereof that described excipient comprises 5.0～55 % by weight, the lubricant that is selected from magnesium stearate, calcium stearate, Talcum, Polyethylene Glycol, sodium stearyl fumarate and composition thereof of 0.2～5.0 % by weight, with the menthol of 0.02～1.0 % by weight, in the gross weight of described pad pasting.

With respect to the gross weight meter of described pad pasting, in described mouth paster, comprise one or more biological adhesives of 10～80 % by weight and one or more excipient of 5.0～60 % by weight.

In use, if used in pad pasting mode, once each tooth position is 1 for described Chinese medicine composition, and every 2～3 hours once, and one day 5～6 times, every 7 days is a course for the treatment of.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Acute toxicity testing and the long term toxicity test of embodiment 1 Chinese medicine composition of the present invention

Experimental agents:

By 18g Radix Rehmanniae Preparata, the 12g Radix Paeoniae Alba, 50g Fructus Rubi, 40g Fructus Ligustri Lucidi, 35g Herba Ecliptae, 25g Herba Cistanches and 20g Semen Astragali Complanati mix, be ground into 100 object powder, with determining alcohol, be that 95% ethanol 600g is as solvent, dipping 24h, adopt percolation with the speed of 2ml per minute percolation slowly, collect the liquid 500g that just filters, preserve separately, till continuation percolation is light to percolate color, collect the continuous liquid of filtering, being concentrated into relative density is the thick paste of 1.22 (70 ℃), add the 500g liquid of just filtering, mix, standing, after clarifying, filter, obtain fluid extract, after volatilization residual solvent, drying under reduced pressure is to dried cream powder, be ground into 50 order to 100 object fine powders, 15g Rhizoma Phragmitis, 16g Rhizoma Coptidis, the 13g Rhizoma Atractylodis Macrocephalae, 12g Semen Phaseoli, 10g Exocarpium Benincasae and 13g Radix Glycyrrhizae are mixed, add 400g decocting and boil 3 times, decoct 1h at every turn, filter respectively, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.14 (70 ℃), 14g Magnetitum and 20g Gypsum Fibrosum are mixed, be ground into 100 object fine powders, the clear paste obtaining, fine powder and 10g starch mix, and carry out subsequently pelletization treatment, dried, obtain compound particles, the fine powder of dried cream powder, compound particles are mixed with 1.5g magnesium stearate, obtain capsule 's content, capsule 's content is incapsulated in housing and obtains capsule, the specification of capsule is 0.35g/ grain.

Test method:

60 of application NIH mices, SPF level, male and female half and half, body weight 18～22g，You Guangdong Medical Lab Animal Center provide, and carry out acute toxicity testing.Mice is divided into two groups at random, be matched group and administration group, fasting 12 hours before experiment, (concentration is 6.28g crude drug/ml then to give the Chinese medicinal composition capsules suspension of the invention described above, maximum concentration) gavage, gavage volume is 5ml/kg (being that single-dose dosage is 31.4g crude drug/kg), and matched group gives equivalent normal saline, administration in 1 day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and records toxic reaction and the death toll of mice, specifically refers to table 1.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, mice overall health of patients, ingest, drinking-water, body weight gain is all normal.Mice oral administration gavage capsule LD of the present invention ₅₀> 31.4g crude drug/kg, every day, maximum dosage-feeding was 62.8g crude drug/kg/ day.Chinese medicine composition clinical application amount of the present invention is 2.1g crude drug/day/people, becomes body weight for humans in 60kg, and average dosage is 0.035g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight take 20g) oral administration gavage Chinese medicine composition of the present invention is quantity 897 times.Therefore Chinese medicine composition acute toxicity of the present invention is low, clinical drug safety.

Table 1: the oral the acute toxicity tests that gavages Chinese medicinal composition capsules of the present invention of mice

The long term toxicity test of Chinese medicine composition of the present invention

Select 132 of female sd inbred rats, SPF level, body weight 80～100g, by Guangdong Medical Lab Animal Center, provided, by body weight, be divided at random 4 groups, be matched group, the basic, normal, high dosage group of Chinese medicinal composition capsules suspension of the present invention (6.4,19.2,57.6g crude drug/kg), 33 every group.Administration group is subject to reagent once every day, successive administration 3 months, 6 months and put to death respectively each 11 of matched groups, basic, normal, high dosage group rat, totally 44 after convalescent period (drug withdrawal 1 month).Duration of test is observed outward appearance, general behavior, body weight change, the amount of drinking water of ingesting of animal, and after administration, 3,6 months and 1 month (convalescent period) of drug withdrawal are carried out the index checkings such as hematology's (RBC, HCT, MCV, MCH, MCHC, HB, PLT, CT, WBC and classification, reticulocyte, clotting time etc.) and serum biochemistry (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, GLOB, A/G, TG, CHOL etc.), organ coefficient, histopathology.Result of the test shows: each treated animal general state is good, and outward appearance sign, behavioral activity, body weight gain are all without ANOMALOUS VARIATIONS; Three dosage groups and matched group are learned and are checked all in normal range at administration 3,6 months and drug withdrawal hematological examination after 1 month, blood biochemical, between group without significant difference; Each is organized main organs tissue and has no the pathology variation relevant to medicine.This test dosage is respectively 182,548,1634 times of clinical medicine dose, according to result of the test, show: basic, normal, high three dosage of Chinese medicine composition of the present invention (6.4,19.2,57.6g crude drug/kg) administration in continuous 3,6 months has no significant effect rat, without clear and definite toxicity target organ and sensitive indicator, convalescent period observes and also has no retardance toxic reaction, therefore the long term toxicity of Chinese medicine composition of the present invention is low, and the dosage safety of clinical practice is high.

Decoct prepared by embodiment 2 Chinese medicine composition of the present invention

16g Radix Rehmanniae Preparata, the 13g Radix Paeoniae Alba, 47g Fructus Rubi, 35g Fructus Ligustri Lucidi, 32g Herba Ecliptae, 25g Herba Cistanches, 20g Semen Astragali Complanati, 13g Magnetitum, 17g Gypsum Fibrosum, 14g Rhizoma Phragmitis, 16g Rhizoma Coptidis, the 13g Rhizoma Atractylodis Macrocephalae, 11g Semen Phaseoli, 10g Exocarpium Benincasae and 12g Radix Glycyrrhizae are mixed, be ground into powder; Acquisition powder is added in 1150g cold water and soaked 12 hours, and with slow fire boiling, decocting time is 2 hours, and decoction liquor is filtered, and obtains the first filtrate; By filtering the filtering residue obtaining, again add in 1150g cold water, with slow fire boiling 3 hours, filter and obtain the second filtrate; Merge filtrate twice, obtain described decoct.

Capsule prepared by embodiment 3 Chinese medicine composition of the present invention

By 18g Radix Rehmanniae Preparata, the 12g Radix Paeoniae Alba, 50g Fructus Rubi, 40g Fructus Ligustri Lucidi, 35g Herba Ecliptae, 25g Herba Cistanches and 20g Semen Astragali Complanati mix, be ground into 100 object powder, with determining alcohol, be that 95% ethanol 600g is as solvent, dipping 24h, adopt percolation with the speed of 2ml per minute percolation slowly, collect the liquid 500g that just filters, preserve separately, till continuation percolation is light to percolate color, collect the continuous liquid of filtering, being concentrated into relative density is the thick paste of 1.22 (70 ℃), add the 500g liquid of just filtering, mix, standing, after clarifying, filter, obtain fluid extract, after volatilization residual solvent, drying under reduced pressure is to dried cream powder, be ground into 50 order to 100 object fine powders, 15g Rhizoma Phragmitis, 16g Rhizoma Coptidis, the 13g Rhizoma Atractylodis Macrocephalae, 12g Semen Phaseoli, 10g Exocarpium Benincasae and 13g Radix Glycyrrhizae are mixed, add 400g decocting and boil 3 times, decoct 1h at every turn, filter respectively, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.14 (70 ℃), 14g Magnetitum and 20g Gypsum Fibrosum are mixed, be ground into 100 object fine powders, the clear paste obtaining, fine powder and 10g starch mix, and carry out subsequently pelletization treatment, dried, obtain compound particles, the fine powder of dried cream powder, compound particles are mixed with 1.5g magnesium stearate, obtain capsule 's content, capsule 's content is incapsulated in housing and obtains capsule, the specification of capsule is 0.3g/ grain.

Tablet prepared by embodiment 4 Chinese medicine composition of the present invention

18g Radix Rehmanniae Preparata, the 14g Radix Paeoniae Alba, 48g Fructus Rubi, 40g Fructus Ligustri Lucidi, 32g Herba Ecliptae, 25g Herba Cistanches and 20g Semen Astragali Complanati are mixed, be ground into 100 object powder, the ethanol 620g that is 95% with determining alcohol is as solvent, dipping 24h, adopt percolation with the speed of 3ml per minute percolation slowly, collect the liquid 480g that just filters, preserve separately, till continuation percolation is light to percolate color, collect the continuous liquid of filtering, being concentrated into relative density is the thick paste of 1.24 (70 ℃), add the 480g liquid of just filtering, mix, standing, after clarifying, filter, obtain fluid extract; 15g Rhizoma Phragmitis, 16g Rhizoma Coptidis, the 11g Rhizoma Atractylodis Macrocephalae, 11g Semen Phaseoli, 9g Exocarpium Benincasae and 10g Radix Glycyrrhizae are mixed, add 360g decocting and boil three times, each 2h, filters respectively, merging filtrate, and filtrate is condensed into the clear paste that relative density is 1.14 (70 ℃); 13g Magnetitum and 19g Gypsum Fibrosum are mixed, be ground into 100 object fine powders; Described fluid extract is added in described clear paste, mix, after volatilization residual solvent, drying under reduced pressure is to dried cream powder, be ground into 100 object fine powders, the Magnetitum and gypsum mixtures fine powder, 48 starch and the 12g dextrin that add subsequently acquisition, mix homogeneously, granulates, dry, tabletting, makes 1000, tablet after slice, thin piece packing, the specification of the tablet making is 0.3g/ sheet.

Powder prepared by embodiment 6 Chinese medicine composition of the present invention

By each raw material components difference water brush, wash clean, pull out and dry; 16g Radix Rehmanniae Preparata, the 12g Radix Paeoniae Alba, 45g Fructus Rubi, 36g Fructus Ligustri Lucidi, 32g Herba Ecliptae, 22g Herba Cistanches, 18g Semen Astragali Complanati are put into respectively to marmite and fry into charcoal, with pulverizer, pulverized respectively 20 minutes, be screened into 80 object powder; Dried 12g Magnetitum, 20g Gypsum Fibrosum, 13g Rhizoma Phragmitis, 14g Rhizoma Coptidis, the 11g Rhizoma Atractylodis Macrocephalae, 10g Semen Phaseoli, 8g Exocarpium Benincasae and 10g Radix Glycyrrhizae are sent into respectively and in microtome, be cut into flakelet, then send into pulverizer and pulverize 20 minutes, be screened into 80 object powder; Fine powder after gained is sieved drops into mixing and blending machine and fully mixes, and obtains powder, subsequently with bottle or packing box packing.

Pad pasting prepared by embodiment 7 Chinese medicine composition of the present invention

17g Radix Rehmanniae Preparata, the 14g Radix Paeoniae Alba, 50g Fructus Rubi, 36g Fructus Ligustri Lucidi, 34g Herba Ecliptae, 23g Herba Cistanches, 19g Semen Astragali Complanati are put into respectively to marmite and fry into charcoal, with pulverizer, pulverized respectively 20 minutes, sieve, obtain 100 object powder; Dried 14g Magnetitum, 18g Gypsum Fibrosum, 12g Rhizoma Phragmitis, 15g Rhizoma Coptidis, the 12g Rhizoma Atractylodis Macrocephalae, 10g Semen Phaseoli, 9g Exocarpium Benincasae and 11g Radix Glycyrrhizae are sent into respectively and in microtome, be cut into flakelet, then send into pulverizer and pulverize 20 minutes, sieve, obtain 100 object powder; 210g hydroxypropyl emthylcellulose as biological adhesive, carbomer 90g are pulverized 20 minutes with pulverizer, sieve, obtain 100 object powder, 300g starch, 10g magnesium stearate, 5g menthol are mixed and pulverized 20 minutes with pulverizer, sieve, obtain 100 object powder; Material mix homogeneously by sieving and obtaining, is pressed into pad pasting.

Clinical experiment

1.1 case selection standards

1.1.1 include case standard in

(1), above 60 years old following men and women patient of this test and Selection 30 years old, have the above adult periodontitis of moderate, existing dermal tooth number >=10;

(2), in patient oral cavity, have at least the spy of 1 tooth to examine degree of depth 5mm, BOP (+);

(3), patient do not accept periodontal treatment at least one year, healthy, women is gestation, suckling.

(4), TCM Syndrome Type meets kidney-yin deficiency type, with the slight red and swollen atrophy of gingiva, and frequent hemorrhage pyorrhea, root of the tooth a surname reveal, odontoseisis, thirsty parched throat, dizziness and tinnitus, soreness of the waist and knees, feverish sensation in the palms and soles, sleeps poor, red tongue with little fur, the patient that thready and rapid pulse is main symptom.

1.1.2 Excluded cases standard

(1) medicine that, patient's long-term taking causes gingival hyperplasia or affects periodontal tissue's recovery is as benzene, sodium, Cyclosporin A etc.;

(2), patient has serious systemic disease as diabetes, hyperthyroidism, acquired immune deficiency syndrome (AIDS), cardiovascular disease, cancer etc.;

(3), dental caries are bad widely, tooth misplaces, affect examiner.

1.2 case source and groupings

This is organized 135 examples and is outpatient, male 70 examples, female's 65 examples; Be all the medical patients of 2009～2010 Nian Wo institutes, wherein, 30～40 years old 37 examples, 41～50 years old 62 example, 51～60 years old 36 example, select above-mentioned 135 routine Patients with Adult Periodontitis, 1350 teeth, as object of study, are divided into two groups at random by above-mentioned patient, clinical manifestation no significant difference (P > 0.05) before the sex of two groups, age and treatment, wherein treatment group is 70 examples (700 teeth), and matched group is 65 examples (650 teeth).

1.3 observation of curative effect

(1), sign

1, the Periodontal probing degree of depth (PD): with arriving gum edge distance in the periodontal probe record bag end;

2, sulcular bleeding index (SBI): minute 6 degree records;

3, tooth mobility: minute 3 degree records.

1.4 diagnostic criteria

1.4.1 Western medicine diagnose standard

1.4.1.1 periodontal disease light in weight classification Ti

Slight periodontitis: periodontal pocket≤4mm, attachment loss≤2mm, Alveolar Bone Loss≤1/3, root teethes generally not loosening.

Moderate periodontitis tooth: week bag≤6mm, attachment loss≤5mm, Alveolar Bone Loss≤1/2, the long furcation area of root may have slight pathological changes, and tooth may have loosening.

Severe periodontitis tooth: week bag > 6mm, attachment loss > 5mm, Alveolar Bone Loss > 1/2, long bifurcation involvement 2～3 degree of root, tooth generally all has obviously loosening.

1.4.1.2 sulcular bleeding index

Normal gingiva------------------------------------0

Gingiva is not hemorrhage---------1 of edema probe spy slightly

The petechial hemorrhage of gingival edema spy------------------2

Gingival hemorrhage is expanded---------------------3 along gum edge

Gingival hemorrhage overflows gum edge------------------------4

Gingiva has spontaneous bleeding tendency or ulcer------5

1.4.1.3 tooth mobility record

Mobility of tooth surpasses physiological mobility, but in 1mm--------------------I degree

Mobility of tooth amplitude is m-at 1～2mm--------------------------------------II degree

Mobility of tooth amplitude is more than 2mm--------------------------------------III degree

1.4.1.4 periodontitis x-ray frontal resorption record

Frontal resorption is in the neck 1/3 of root of the tooth--------------------------------------------I degree

It is long by 1/3 that frontal resorption surpasses root, in root long 2/3, or absorbs the 1/2---II degree that reaches root length

Frontal resorption accounts for root and grows more than 2/3--------------------------------------------------III degree

1.4.2 tcm diagnosis standard

Red and swollen atrophy that gingiva is slight, and frequent hemorrhage pyorrhea, root of the tooth a surname reveal, odontoseisis, thirsty parched throat, dizziness and tinnitus, soreness of the waist and knees, feverish sensation in the palms and soles, sleeps poor, red tongue with little fur, thready and rapid pulse is main symptom.

1.4.3 curative effect determinate standard

Effective: visit and examine degree of depth minimizing more than 2 millimeters, visit and examine hemorrhage (-), tooth mobility minimizing is more than or equal to 2, and red swelling of gingiva disappears;

Effective: visit and examine 1～2 millimeter of degree of depth minimizing, visit and examine hemorrhage (-), tooth mobility minimizing is more than or equal to 1 and is less than 2, and red swelling of gingiva alleviates, and subjective symptom alleviates;

Invalid: visit and to examine the degree of depth, visit and examine hemorrhage, tooth mobility all without improvement or increase the weight of on the contrary, subjective symptom is without alleviation or increase the weight of on the contrary.

1.5 Therapeutic Method

1.5.1 experimental drug

16g Radix Rehmanniae Preparata, the 13g Radix Paeoniae Alba, 47g Fructus Rubi, 35g Fructus Ligustri Lucidi, 32g Herba Ecliptae, 25g Herba Cistanches, 20g Semen Astragali Complanati, 13g Magnetitum, 17g Gypsum Fibrosum, 14g Rhizoma Phragmitis, 16g Rhizoma Coptidis, the 13g Rhizoma Atractylodis Macrocephalae, 11g Semen Phaseoli, 10g Exocarpium Benincasae and 12g Radix Glycyrrhizae are mixed, be ground into powder; Acquisition powder is added in 1150g cold water and soaked 12 hours, and with slow fire boiling, decocting time is 2 hours, and decoction liquor is filtered, and obtains the first filtrate; By filtering the filtering residue obtaining, again add in 1150g cold water, with slow fire boiling 3 hours, filter and obtain the second filtrate; Merge filtrate twice, obtain decoct.

1.5.2 experimental procedure

Treatment group: tested tooth is carried out on gum after scaling, and further consultation after 1 week, does under ultrasonic gum and scrape and control (adopting ultrasonic scraping to control head), in treatment, with oral decoct above, 3 doses of every days, the morning, noon and afternoon respectively once, every dose of decocting takes at twice, and every 7 days is a course for the treatment of, takes 3 courses for the treatment of.

Matched group: tested tooth is carried out on gum after scaling, and further consultation after 1 week, carries out scraping and controlling under ultrasonic gum, adds metronidazole 0.2g in treatment with oral broad-spectrum antibiotic, vitamin C 0.2g, every day 3 times, then use hibitane collutory 10ml, every day 3 rinsing the mouth; 3% hydrogen peroxide rinses periodontal pocket, and every day 1 time, the local Operand that adopts, continues 3 weeks.

First visit: all patients are completed to scaling and oral hygiene propaganda and education on gum;

Further consultation: carry out periodontal inspection after 1 week, determine that still to examine the trouble tooth that degree of depth >=5mm, spy examine hemorrhage (+) be tested tooth for periodontal pocket is visited, record the Periodontal probing degree of depth, visit and to examine hemorrhage and subjective symptom as red swelling of gingiva, gingival hemorrhage, odontoseisis and all tested teeth are carried out scraping under ultrasonic gum and are controlled after, advise test group patient to adopt weekly test Chinese medicine to take, matched group adds metronidazole 0.2g with oral broad-spectrum antibiotic, vitamin C 0.2g, every day 3 times, use again hibitane collutory 10ml, every day 3 rinsing the mouth; 3% hydrogen peroxide rinses periodontal pocket, and every day 1 time, the local Operand that adopts, continues 3 weeks.

Further consultation after 3 weeks: observe clinical symptoms and carry out periodontal inspection, recording the Periodontal probing degree of depth, gingival hemorrhage index, tooth mobility.And observe subjective symptom: red swelling of gingiva, hemorrhage, odontoseisis etc.

1.6 result

1.6.1 analyze before clinical treatment

1.6.1.1 state of an illness contrast before two groups of medications: in Table 2

Table 2

Group	Tooth number	Index of gingivitis	The moving degree of tooth body	Depth of probe
					Treatment group	700	2.1236	1.6532	6.0029
Matched group	650	2.1261	1.6375	5.9978

Before two groups of medications, state of an illness contrast, X ²=0.47, P > 0.05, difference is not remarkable.

1.6.1.2 the front two groups of subjective symptomss of medication distribute: in Table 3

Table 3

Group	Tooth number	Tooth mobility	Red swelling of gingiva	Gingival hemorrhage
					Treatment group	70	70	68	68

Matched group

65

64

Before two groups of medications, subjective symptoms is compared, X ²=0.391, P > 0.05 difference is not remarkable.

1.6.1.3 the front two groups of pulse condition situations of medication distribute: in Table 4

Table 4

Pulse condition situation comparison before treating, X2=0.667, P > 0.05 difference is not remarkable.

From table 2 to table 4, can find out, selected case is kidney-yin deficiency type periodontitis, the sex for the treatment of group and matched group, age structure, the state of an illness, tongue fur from medication, relatively the seeing of the subjective symptomss such as pulse condition, between two groups, without significant difference, the front two groups of cases of medicine taking prompting are without comparability.

1.6.2 clinical treatment post analysis

Implementing scaling under the ultrasonic gum of periodontal, take Chinese medicine composition decoct of the present invention and broad-spectrum antibiotic subsequently and add metronidazole after 3 weeks, by clinical examination, visit and examine the degree of depth, index of gingivitis, the moving degree of tooth body, observe the variation of clinical symptoms, and according to clinical efficacy, criterion contrasts two groups of curative effect situations.

1.6.2.1 two groups of curative effect of medication contrasts: in Table 5

Table 5

Group	Tooth number	Obvious effective rate	Effective percentage	Inefficiency	Total effective rate
						Treatment group	700	276(39.4％)	397(56.7％)	27(3.8％)	96.2％
Matched group	650	130(20％)	217(33.4％)	303(46.6％)	53.4％

According to general curative effect criterion, treatment group and matched group total effective rate are respectively 96.2% and 53.4%, and both have bigger difference treatment group obvious effective rate is 39.4%, and matched group is 20%.

1.6.2.2 visit and examine the degree of depth, index of gingivitis, the variation of the moving degree of tooth body: in Table 6

Table 6

After medication, exist spy to examine the degree of depth, the moving degree of tooth body and index of gingivitis and obviously decline, relatively the go up treatment group of this point between two groups is better than matched group.

Red and swollen atrophy that gingiva is slight, and frequent hemorrhage pyorrhea, root of the tooth a surname reveal, odontoseisis, thirsty parched throat, dizziness and tinnitus, soreness of the waist and knees, feverish sensation in the palms and soles, sleeps poor, red tongue with little fur, thready and rapid pulse.

Model case 1

Patient Wang, man, 41 years old, medical on June 12nd, 2010.Main suit: the frequent hemorrhage pyorrhea of tooth, odontoseisis, dizziness and tinnitus, few sleep, check: the upper most of red swelling of gingiva of lower jaw, that touches is easily hemorrhage, deep periodontal pocket 5mm, periodontal pocket often has pus and blood sexual secretion, odontoseisis II degree before upper and lower, thready pulse, through x radiological survey X, it is long by 1/3 that frontal resorption surpasses root, in root long 2/3.Western medicine diagnose: moderate periodontitis, tcm diagnosis: kidney-yin deficiency type periodontitis, use following formula to cure: by 18g Radix Rehmanniae Preparata, the 12g Radix Paeoniae Alba, 50g Fructus Rubi, 40g Fructus Ligustri Lucidi, 35g Herba Ecliptae, 25g Herba Cistanches and 20g Semen Astragali Complanati mix, be ground into 100 object powder, with determining alcohol, be that 95% ethanol 600g is as solvent, dipping 24h, adopt percolation with the speed of 2ml per minute percolation slowly, collect the liquid 500g that just filters, preserve separately, till continuation percolation is light to percolate color, collect the continuous liquid of filtering, being concentrated into relative density is the thick paste of 1.22 (70 ℃), add the 500g liquid of just filtering, mix, standing, after clarifying, filter, obtain fluid extract, after volatilization residual solvent, drying under reduced pressure is to dried cream powder, be ground into 50 order to 100 object fine powders, 15g Rhizoma Phragmitis, 16g Rhizoma Coptidis, the 13g Rhizoma Atractylodis Macrocephalae, 12g Semen Phaseoli, 10g Exocarpium Benincasae and 13g Radix Glycyrrhizae are mixed, add 400g decocting and boil 3 times, decoct 1h at every turn, filter respectively, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.14 (70 ℃), 14g Magnetitum and 20g Gypsum Fibrosum are mixed, be ground into 100 object fine powders, the clear paste obtaining, fine powder and 10g starch mix, and carry out subsequently pelletization treatment, dried, obtain compound particles, the fine powder of dried cream powder, compound particles are mixed with 1.5g magnesium stearate, obtain capsule 's content, capsule 's content is incapsulated in housing and obtains capsule, the specification of capsule is 0.35g/ grain.Every day 3 times, the morning, noon and afternoon, respectively once each 3,7 days courses for the treatment of, through 6 courses for the treatment of, periodontitis symptom disappeared completely, follows up a case by regular visits to and does not recur half a year.

Model case 2

Patient is in certain, and female, 49 years old, goes to a doctor on May 17th, 2010.Before 2 weeks, there is toothache in burst labial teeth pain, and hemorrhage, pain increases the weight of to some extent recently, thirsty parched throat, and dizziness and tinnitus, soreness of the waist and knees, feverish sensation in the palms and soles, sleeps poor, affects diet.Check: periodontal pocket is all greater than 4mm, the obvious red and swollen atrophy of gingiva, touching is hemorrhage pyorrhea, root of the tooth a surname reveal, odontoseisis II degree, red tongue with little fur, thready and rapid pulse.Western medicine diagnose: moderate periodontitis, tcm diagnosis: kidney-yin deficiency type periodontitis, use following formula to cure: 16g Radix Rehmanniae Preparata, the 13g Radix Paeoniae Alba, 47g Fructus Rubi, 35g Fructus Ligustri Lucidi, 32g Herba Ecliptae, 25g Herba Cistanches, 20g Semen Astragali Complanati, 13g Magnetitum, 17g Gypsum Fibrosum, 14g Rhizoma Phragmitis, 16g Rhizoma Coptidis, the 13g Rhizoma Atractylodis Macrocephalae, 11g Semen Phaseoli, 10g Exocarpium Benincasae and 12g Radix Glycyrrhizae to be mixed, be ground into powder; Acquisition powder is added in 1150g cold water and soaked 12 hours, and with slow fire boiling, decocting time is 2 hours, and decoction liquor is filtered, and obtains the first filtrate; By filtering the filtering residue obtaining, again add in 1150g cold water, with slow fire boiling 3 hours, filter and obtain the second filtrate; Merge filtrate twice, obtain decoct, every day 3 times, the morning, noon and afternoon respectively once, take for every dose minute 2 times, and 7 days courses for the treatment of, through 5 courses for the treatment of, periodontitis symptom disappears completely, follows up a case by regular visits to and does not recur half a year.

All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims

1. a Chinese medicine composition that is used for the treatment of kidney-yin deficiency type periodontitis, it is characterized in that, comprising: Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Fructus Rubi, Fructus Ligustri Lucidi, Herba Ecliptae, Herba Cistanches, Semen Astragali Complanati, Magnetitum, Gypsum Fibrosum, Rhizoma Phragmitis, Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae, Semen Phaseoli, Exocarpium Benincasae and Radix Glycyrrhizae;

The ratio of weight and number of each component in described Chinese medicine composition is, Radix Rehmanniae Preparata 12～18 weight portions, the Radix Paeoniae Alba 10～14 weight portions, Fructus Rubi 35～50 weight portions, Fructus Ligustri Lucidi 30～40 weight portions, Herba Ecliptae 27～35 weight portions, Herba Cistanches 19～25 weight portions, Semen Astragali Complanati 16～20 weight portions, Magnetitum 8～14 weight portions, Gypsum Fibrosum 15～20 weight portions, Rhizoma Phragmitis 10～15 weight portions, Rhizoma Coptidis 12～16 weight portions, the Rhizoma Atractylodis Macrocephalae 9～13 weight portions, Semen Phaseoli 8～12 weight portions, Exocarpium Benincasae 6～10 weight portions and Radix Glycyrrhizae 8～13 weight portions.

2. the preparation method of Chinese medicine composition claimed in claim 1, is characterized in that, when the dosage form of described Chinese medicine composition is decoct, its preparation method comprises the following steps:

A, described component is mixed in proportion, is ground into powder;

D, merge filtrate twice, obtain described decoct.

3. the preparation method of Chinese medicine composition claimed in claim 1, is characterized in that, when the dosage form of described Chinese medicine composition is tablet, its preparation method comprises the following steps:

1, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Fructus Rubi, Fructus Ligustri Lucidi, Herba Ecliptae, Herba Cistanches and Semen Astragali Complanati are mixed in proportion, are ground into powder, use ethanol as solvent, dipping, adopts percolation with the speed of 1～3ml per minute percolation slowly, collects the liquid of just filtering appropriate, preserve separately, till continuation percolation is light to percolate color, collect the continuous liquid of filtering, be concentrated into thick paste, add the liquid of just filtering, mix, standing, after clarifying, filter, obtain fluid extract;

4. the preparation method of Chinese medicine composition claimed in claim 1, is characterized in that, when the dosage form of described Chinese medicine composition is capsule, its preparation method comprises the following steps:

5. the preparation method of Chinese medicine composition claimed in claim 1, is characterized in that, when the dosage form of described Chinese medicine composition is powder, its preparation method comprises the following steps:

A, by described raw material water brush, wash clean, pull out and dry;

6. the preparation method of Chinese medicine composition claimed in claim 1, is characterized in that, when the dosage form of described Chinese medicine composition is pad pasting, its preparation method comprises the following steps: