CN102266464A

CN102266464A - Chinese medicinal composition for treating periodontitis

Info

Publication number: CN102266464A
Application number: CN2011102035247A
Authority: CN
Inventors: 张安美
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-07-11
Filing date: 2011-07-11
Publication date: 2011-12-07
Anticipated expiration: 2031-07-11
Also published as: CN102266464B

Abstract

The invention discloses a Chinese medicinal composition for treating periodontitis. Traditional Chinese medical science considers that the periodontitis belongs to the category of 'gingival atrophy' and 'toothache', and the pathogenesis is excessive pathogenic fire or hyperactivity of deficiency fire. Clinical researches conducted by the hospital in recent years indicate that on the basis of the therapeutic principle of clearing stomach and reducing pathogenic fire, detoxicating and reliving swelling, cooling blood and stopping bleeding, eliminating blood stasis and dredging collaterals and nourishing yin and tonifying kidney, the Chinese medicinal composition has a good treatment effect. Decoction is prepared from bupleurum, golden thread, liquoric root, Mongolian dandelion herb, platycodon root, Szechuan lovage rhizome, Chinese arborvitae twig, cortex moutan, peach seed, Chinese angelica, white paeony root, prepared rehmannia root, cinnamomvine and medlar. Clinical trials prove that: the cure rate is 82.4 percent, the effective rate is 96.3 percent and is obviously higher than that of a control group. In addition, the Chinese medicinal composition does not have toxic or side effect, and is high in anti-inflammatory capacity, quick in detumescence and safe and reliable in a curative effect.

Description

A kind of Chinese medicine composition for the treatment of periodontitis

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of periodontitis.

Background technology

Periodontitis is meant the chronic inflammatory disease that occurs in gingiva, periodontal ligament, cementum and alveolar bone position, most cases are developed by long-standing gingivitis, form periodontal pocket and frontal resorption symptom because the course of disease is slow, early symptom does not cause obvious misery, the normal untimely prescription on individual diagnosis of patient, the limbs disorganization is increased the weight of gradually, finally cause loss of tooth.At present, the treatment of periodontitis mainly contains operative treatment and Drug therapy, and the operative treatment wound is big, and the patient generally is difficult to accept, and Drug therapy is no matter Chinese medicine or western medicine effect are all undesirable.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of periodontitis.The traditional Chinese medical science thinks that periodontitis belongs to " gingival atrophy ", " toothache " category, and its pathogenesis is the flourishing or hyperactivity of deficient fire of pathogenic fire.Show that by my institute's clinical research in recent years the treatment by Chinese herbs primary disease is with the clearing stomach pathogenic fire reducing, removing toxic substances and promoting subsidence of swelling, cooling blood for hemostasis, disperse blood stasis and dredge collateral, enriching yin and nourishing kidney are the rule of treatment, therapeutic effect is better.

The objective of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment periodontitis is made by following parts by weight of Chinese traditional medicine: Radix Bupleuri 20-30 part, Rhizoma Coptidis 10-15 part, Radix Glycyrrhizae 15-25 part, Herba Taraxaci 7-12 part, Radix Platycodonis 10-15 part, Rhizoma Chuanxiong 15-20 part, Cacumen Platycladi 7-12 part, Cortex Moutan 10-20 part, Semen Persicae 15-25 part, Radix Angelicae Sinensis 10-20 part, Radix Paeoniae Alba 7-12 part, Radix Rehmanniae Preparata 15-25 part, Rhizoma Dioscoreae 7-12 part, Fructus Lycii 10-15 part.

Preferably, the Chinese medicine composition of this treatment periodontitis is made by following parts by weight of Chinese traditional medicine: 25 parts of Radix Bupleuri, 12 parts of Rhizoma Coptidis, 20 parts in Radix Glycyrrhizae, 10 parts of Herba Taraxacis, 13 parts of Radix Platycodoniss, 17 parts of Rhizoma Chuanxiongs, 9 parts of Cacumen Platycladis, 15 parts of Cortex Moutans, 20 parts in Semen Persicae, 15 parts of Radix Angelicae Sinensis, 9 parts of the Radix Paeoniae Albas, 20 parts in Radix Rehmanniae Preparata, 10 parts of Rhizoma Dioscoreaes, 13 parts of Fructus Lycii.

The fried decoction of decocting method is taken routinely.

In the side: Radix Bupleuri is evacuated and is brought down a fever the yang invigorating soothing liver-QI; Radix Glycyrrhizae, Rhizoma Coptidis, Herba Taraxaci heat clearing and damp drying, eliminating fire and detoxication, dispersing swelling and dissipating binds; The Radix Platycodonis lung qi dispersing eliminates the phlegm, the sore-throat relieving evacuation of pus; The Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping; The cool hemostasis of Cacumen Platycladi, wind-damp dispelling, toxic swelling looses; The Cortex Moutan clearing away heat and cooling blood, promoting blood circulation to remove blood stasis; Semen Persicae, Radix Angelicae Sinensis, Radix Paeoniae Alba blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain; Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Lycii enriching yin and nourishing kidney.

Through my institute's clinical trial, use this to invent described traditional Chinese medicine composition for treating periodontitis, can eliminate periodontal tissue's local inflammation effectively, make gums swelling pain and simultaneous phenomenon be alleviated, disappear, thereby the raising curative effect shortens the course of disease, reduces recurrence, promote early more, reach strengthening vital QI to eliminate pathogenic factors, heat-clearing and toxin-vanquishing, evacuation of pus detumescence, the hemostasis teeth consolidating, the purpose of deodorization analgesic therapy.

Clinical data

1, physical data 216 routine patients with periodontitis are the Stomatology Clinic patient of the court.Be acute stage or chronic periodontitis acute attack patient.Be divided into two groups at random, 108 examples are organized in treatment, male 58 examples, women 50 examples; The oldest 65 years old, minimum 28 years old, average 45.5 ± 4.50 years old; The course of disease is the longest 22 years, and is the shortest 0.5 year, average 5.5 ± 2.5 years.Matched group 108 examples, male 51 examples, women 57 examples; The oldest 64 years old, minimum 29 years old, average 45 ± 5.5 years old; The course of disease is the longest 22 years, and is the shortest 5 months, average 5.2 ± 2.40 years.Two groups of sexes, age, courses of disease compare, and difference that there are no significant has comparability.

2, diagnostic criteria is with reference to " oral medicine " ⁽¹⁾In the diagnostic criteria diagnosis of relevant periodontitis.Meet above-mentioned diagnostic criteria, select marginal gingivitis, hepertrophic gingivitis in papillary gingivitis, acute multiple gingival abscess and the chronic gingivitis in the acute gingivitis; Chinese medical discrimination belongs to excessiveness of stomach-fire or deficiency of kidney-YIN, hyperactivity of deficient fire person; Go to a doctor and do not use the antibiotic person the last week, as the object of observation.Suffer from serious systemic disease, anemia of pregnant woman and women breast-feeding their children, uncooperative or follow up a case by regular visits to difficult person and do not list the object of observation in.

3, Therapeutic Method treatment group is taken Chinese medicine composition of the present invention, and 1 dose of every day, decocting 2 times divides clothes sooner or later; Medicinal residues add that water is dense to be fried in shallow oil, the frequent rinsing the mouth of filtrate gradation.Matched group gives the metronidazole sheet, each 0.2g, every day 3 times, warm water delivery service.Two groups was 1 course of treatment with 7 days all, added up therapeutic outcome after treating a course of treatment.

4, criterion of therapeutical effect is drafted with reference to the chief editor's who opens act " oral medicine " third edition and Sun Chuanxing chief editor's " clinical disease diagnosis is according to curing the improvement standard ".Recovery from illness: pain disappears, and gingiva recovers normal color and form, and periodontal pocket disappears or periodontal abscess disappears, and tooth is not loosening.Produce effects: pain relief, gingiva outward appearance recover normally substantially, and periodontal pocket shoals or periodontal abscess disappears, and tooth mobility reduces.Effectively: the gingiva mild swelling, acute periodontal abscess disappears substantially.Invalid: symptom, sign do not have and are clearly better.

5, two groups of clinical efficacies of therapeutic outcome relatively see Table 1.

Table 1 liang group clinical efficacy relatively

Annotate: 1. P＜0.01.

Two groups of total effective rates relatively have significant difference (P＜0.01), and the treatment group is better than matched group.Treatment group patient is no any bad toxicity in therapeutic process, and matched group has 46 examples malaise symptoms such as dizziness, appetite depression to occur, alleviates gradually after the drug withdrawal.

The specific embodiment

Embodiment one: get Radix Bupleuri 25g, Rhizoma Coptidis 12g, Radix Glycyrrhizae 20g, Herba Taraxaci 10g, Radix Platycodonis 13g, Rhizoma Chuanxiong 17g, Cacumen Platycladi 9g, Cortex Moutan 15g, Semen Persicae 20g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba 9g, Radix Rehmanniae Preparata 20g, Rhizoma Dioscoreae 10g, Fructus Lycii 13g, decocting method is made decoction routinely, 1 dose of every day, decocting 2 times divides clothes sooner or later; Medicinal residues add that water is dense to be fried in shallow oil, the frequent rinsing the mouth of filtrate gradation.

Embodiment two: get Radix Bupleuri 20g, Rhizoma Coptidis 15g, Radix Glycyrrhizae 15g, Herba Taraxaci 12g, Radix Platycodonis 15g, Rhizoma Chuanxiong 15g, Cacumen Platycladi 12g, Cortex Moutan 10g, Semen Persicae 25g, Radix Angelicae Sinensis 10g, Radix Paeoniae Alba 12g, Radix Rehmanniae Preparata 25g, Rhizoma Dioscoreae 7g, Fructus Lycii 10g, decocting method is made decoction routinely, 1 dose of every day, decocting 2 times divides clothes sooner or later; Medicinal residues add that water is dense to be fried in shallow oil, the frequent rinsing the mouth of filtrate gradation.

Embodiment three: get Radix Bupleuri 30g, Rhizoma Coptidis 10g, Radix Glycyrrhizae 25g, Herba Taraxaci 7g, Radix Platycodonis 10g, Rhizoma Chuanxiong 20g, Cacumen Platycladi 7g, Cortex Moutan 20g, Semen Persicae 15g, Radix Angelicae Sinensis 20g, Radix Paeoniae Alba 7g, Radix Rehmanniae Preparata 15g, Rhizoma Dioscoreae 12g, Fructus Lycii 15g, decocting method is made decoction routinely, 1 dose of every day, decocting 2 times divides clothes sooner or later; Medicinal residues add that water is dense to be fried in shallow oil, the frequent rinsing the mouth of filtrate gradation.

Claims

1. a Chinese medicine composition for the treatment of periodontitis is characterized in that being made by following parts by weight of Chinese traditional medicine: Radix Bupleuri 20-30 part, Rhizoma Coptidis 10-15 part, Radix Glycyrrhizae 15-25 part, Herba Taraxaci 7-12 part, Radix Platycodonis 10-15 part, Rhizoma Chuanxiong 15-20 part, Cacumen Platycladi 7-12 part, Cortex Moutan 10-20 part, Semen Persicae 15-25 part, Radix Angelicae Sinensis 10-20 part, Radix Paeoniae Alba 7-12 part, Radix Rehmanniae Preparata 15-25 part, Rhizoma Dioscoreae 7-12 part, Fructus Lycii 10-15 part.

2. a kind of Chinese medicine composition for the treatment of periodontitis according to claim 1 is characterized in that being made by following parts by weight of Chinese traditional medicine: 25 parts of Radix Bupleuri, 12 parts of Rhizoma Coptidis, 20 parts in Radix Glycyrrhizae, 10 parts of Herba Taraxacis, 13 parts of Radix Platycodoniss, 17 parts of Rhizoma Chuanxiongs, 9 parts of Cacumen Platycladis, 15 parts of Cortex Moutans, 20 parts in Semen Persicae, 15 parts of Radix Angelicae Sinensis, 9 parts of the Radix Paeoniae Albas, 20 parts in Radix Rehmanniae Preparata, 10 parts of Rhizoma Dioscoreaes, 13 parts of Fructus Lycii.