CN102028842B - Medicament for treating dysmenorrhea and preparation method thereof - Google Patents
Medicament for treating dysmenorrhea and preparation method thereof Download PDFInfo
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- CN102028842B CN102028842B CN2010105867359A CN201010586735A CN102028842B CN 102028842 B CN102028842 B CN 102028842B CN 2010105867359 A CN2010105867359 A CN 2010105867359A CN 201010586735 A CN201010586735 A CN 201010586735A CN 102028842 B CN102028842 B CN 102028842B
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- 239000003814 drug Substances 0.000 title claims abstract description 39
- 206010013935 Dysmenorrhoea Diseases 0.000 title claims abstract description 33
- 208000005171 Dysmenorrhea Diseases 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 241000218176 Corydalis Species 0.000 claims abstract description 9
- 240000000031 Achyranthes bidentata Species 0.000 claims abstract 2
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 claims abstract 2
- 240000007890 Leonurus cardiaca Species 0.000 claims abstract 2
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 claims abstract 2
- 244000197580 Poria cocos Species 0.000 claims abstract 2
- 235000008599 Poria cocos Nutrition 0.000 claims abstract 2
- 241000304195 Salvia miltiorrhiza Species 0.000 claims abstract 2
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims abstract 2
- 239000003610 charcoal Substances 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims description 10
- 238000002791 soaking Methods 0.000 claims 2
- 241000675108 Citrus tangerina Species 0.000 claims 1
- 244000046146 Pueraria lobata Species 0.000 claims 1
- 235000010575 Pueraria lobata Nutrition 0.000 claims 1
- 241000157352 Uncaria Species 0.000 claims 1
- 239000000706 filtrate Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 230000002175 menstrual effect Effects 0.000 abstract description 4
- 210000001015 abdomen Anatomy 0.000 abstract description 3
- 208000024891 symptom Diseases 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 2
- 208000011580 syndromic disease Diseases 0.000 abstract description 2
- 206010000084 Abdominal pain lower Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 11
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 7
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 7
- 229910052799 carbon Inorganic materials 0.000 description 7
- 210000003734 kidney Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 238000002386 leaching Methods 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000005303 weighing Methods 0.000 description 5
- 241000219780 Pueraria Species 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 3
- 210000004291 uterus Anatomy 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 2
- 210000004696 endometrium Anatomy 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 230000003340 mental effect Effects 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 208000007106 menorrhagia Diseases 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000001113 umbilicus Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗痛经的药物及其制备方法，该药物包括下列原料：香附10～15份、茯苓10～15份、五灵脂10～15份、蒲黄炭10～15份、牛膝10～18份、牡丹皮10～16份、丹参10～12份、延胡索15～18份、桂枝6～8份、益母草12～18份。该药物的制备方法为：首先称取各原料，备用；然后将各原料用水浸泡15～30分钟后，武火煮沸，文火煎15～20分钟，过滤取滤液，即得所述治疗痛经的药物。本发明的优点是对于原发性痛经、膜样痛经、经行综合症等而出现的小腹疼痛，月经量多或少，夹有膜样血块，小腹怕冷等症状有明显疗效。The invention discloses a medicine for treating dysmenorrhea and a preparation method thereof. The medicine comprises the following raw materials: 10-15 parts of Rhizoma Cyperi, 10-15 parts of Poria cocos, 10-15 parts of Wulingzhi, 10-15 parts of Puhuang Charcoal, Achyranthes bidentata 10-18 parts, Moutan bark 10-16 parts, Salvia miltiorrhiza 10-12 parts, Corydalis 15-18 parts, Guizhi 6-8 parts, Motherwort 12-18 parts. The preparation method of the medicine is as follows: firstly, each raw material is weighed and set aside; then each raw material is soaked in water for 15 to 30 minutes, then boiled with strong fire, decocted with slow fire for 15 to 20 minutes, and filtrated to obtain the medicine for treating dysmenorrhea. The advantages of the present invention are that it has obvious curative effect on symptoms such as primary dysmenorrhea, membranous dysmenorrhea and menstrual syndrome, such as lower abdominal pain, heavy or less menstrual flow, membranous blood clots, lower abdomen afraid of cold and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, specifically a kind of medicine of treating dysmenorrhea and preparation method thereof.
Background technology
The Complete Effective Prescriptions for Diseases of Women points out to treat dysmenorrhea side's medicine, thinks that " air-cooled gas visitor is in uterus, and the arteries and veins of appointing is dashed in damage " is so morbidity.Pass through the understanding of forefathers to primary disease; Through big quantity research to primary disease treatment and square medicine; In conjunction with modern medicine dysmenorrhea has been summed up several kinds of reasons: the hypoplasia in uterus, irregular shedding of endometrium, metrocampsis, physical factors, Nervous and Mental Factors etc., take in factor such as air-cooled, cold-damp the day after tomorrow in addition and bring out dysmenorrhea.The generation of dysmenorrhea and the stasis of blood stagnate, cold coagulation, stagnated fire have confidential relation.Stagnation of QI and blood may bring about pain, general rule are not bitterly." Shen Shi woman section summary writing paper is just being debated color and pain " medium cloud: " through the preceding pain cloudy stagnation of QI of fainting nothing but, channels is not dredged." except the appeal factor is also not enough with natural endowment, the hypoplasia in uterus, irregular shedding of endometrium, metrocampsis, physical factors, Nervous and Mental Factors etc. are relevant.Not only pay attention to dispelling cold by warming the meridian when therefore treating, blood-activating analgetic also will pay attention to nursing one's health conscience spleen kidney." Medical Treasures of the Golden Chamber " be cloud also, pain person, and stringy pulse, promptly pain is relevant with liver.Train of thought is suddenly clumsy, and why contracting does pain if curling up, dominated by conscience, reaches qi and blood so transfer, and alleviates contraction and suddenly focuses on stable conscience.Spleen is a source of generating QI and blood, and kidney is a foundation of acquired constitution, says in " Shengji Zonglu unmarried girl menstrual abdominalgia ": " unmarried girl's menstrual abdominalgia person, with Radix Semiaquilegiae extremely; Rong Wei becomes estranged first, malaise, for cold the visitor; its blood and gas are unfluent, cause menstruation tie fight interventral in umbilicus, as stinging pain." have only and fundamentally eliminate source of disease, be only the very wise move of treatment.But treat dysmenorrhea at present, often only pay attention to dispelling cold by warming the meridian, blood-activating analgetic, and ignored conditioning conscience spleen kidney.
Summary of the invention
Goal of the invention: first purpose of the present invention is to provide a kind of medicine of treating dysmenorrhea, and this medicine is strengthened the merit of Liver and kidney self-restraint on basis in the past, promote transformation coming from spleen, hands over Ji heart kidney yin rising tone to weigh, and can fundamentally eliminate source of disease.
Second purpose of the present invention is for a kind of method for preparing of treating the medicine of dysmenorrhea is provided.
Technical scheme: in order to solve above-mentioned first purpose; The technical scheme that the present invention adopted is: a kind of medicine of treating dysmenorrhea, it comprises the raw material of following weight portion: 10～15 parts of Rhizoma Cyperis, 10～15 parts in Poria, 10～15 parts of Oletum Trogopteroris, 10～15 parts of Pollen Typhae carbon, 10～18 parts of Radix Achyranthis Bidentataes, 10～16 parts of Cortex Moutans, 10～12 parts of Radix Salviae Miltiorrhizaes, 15～18 parts of Rhizoma Corydalis, 6～8 parts of Ramulus Cinnamomi, 12～18 parts of Herba Leonuris.
Also comprise Pericarpium Citri Reticulatae 6～11 weight portions, Ramulus Uncariae Cum Uncis 15～30 weight portions, Radix Dipsaci 15～30 weight portions, Radix Puerariae 13～20 weight portions.
In order to solve above-mentioned second purpose, the technical scheme that the present invention adopted is: a kind of method for preparing of treating the medicine of dysmenorrhea, this method comprises the steps:
1) take by weighing each raw material, subsequent use;
2) raw material in the step 1) was soaked in water 15～30 minutes after, intense fire boils, 15～20 minutes at a simmer, cross leaching filtrating, promptly get the medicine of said treatment dysmenorrhea.
Step 2) in, when being soaked in water, water covers powder 2～3cm and is advisable.
Beneficial effect: compared with prior art, advantage of the present invention is: medicine of the present invention is strengthened the merit of Liver and kidney self-restraint on basis in the past, promote transformation coming from spleen, hands over Ji heart kidney yin rising tone to weigh, and can fundamentally eliminate source of disease; For primary dysmenorrhea, membranous dysmenorrhea, the lower abdomen pain that occurs through row syndrome etc., menorrhagia or few accompanies film sample of blood piece, and lower abdomen symptom such as be afraid of cold has obvious curative effects.
Select 100 patients to carry out system's clinical observation according to conditions of patients, test group is taken this medicine, usage and dosage: one day twice, and decoction being taken warmly; Granule is directly taken after mixing it with water in this way, and one day twice, decoction being taken warmly was taken after half an hour after meal; Matched group is treated according to conventional method; Observed 3 months, one month is a course of treatment, totally 3 courses of treatment.
Test group: first course of treatment prescription: Rhizoma Cyperi 10g, Poria 10g, Oletum Trogopterori 10g, Pollen Typhae carbon 10g, Radix Achyranthis Bidentatae 10g, Cortex Moutan 10g, Radix Salviae Miltiorrhizae 10g, Rhizoma Corydalis 15g, Ramulus Cinnamomi 6g, Herba Leonuri 15g; 30 patient's pain relieves are arranged; But inferior month painful again; And the patient's gastrointestinal tract malaise symptoms is obvious, and it is rare to defecate, stomach discomfort; Second course of treatment, first the course of treatment prescription the basis on add Ramulus Uncariae Cum Uncis 15g, Radix Puerariae 15g, Pericarpium Citri Reticulatae 6g Radix Dipsaci 15g, patient's gastrointestinal tract is uncomfortable obviously to be improved, pain does not show; The 3rd course of treatment, after treatment, used prescription is identical with second course of treatment, and 46 significant curative effects are arranged, and also has 4 and take a favorable turn.
The curative effect of test group and matched group clinical trial is as shown in the table:
Test data statistics in the last table shows that take the patient of this medicine, what significant curative effect was arranged accounts for 92%, accounts for 20% and matched group has a significant curative effect, and hence one can see that, and test group has the matched group that is far longer than of significant curative effect, and the value of clinical expansion is arranged.
The specific embodiment
Through concrete embodiment the present invention is further specified below; Should be pointed out that for the person of ordinary skill of the art, under the prerequisite that does not break away from the principle of the invention; Can also make some modification and improvement, these also should be regarded as belonging to protection scope of the present invention.
Embodiment 1: a kind of medicine of treating dysmenorrhea; It comprises the raw material of following weight portion: 10 parts of Rhizoma Cyperis, 10 parts in Poria, 10 parts of Oletum Trogopteroris, 10 parts of Pollen Typhae carbon, 10 parts of Radix Achyranthis Bidentataes, 6 parts of Pericarpium Citri Reticulataes, 15 parts of Ramulus Uncariae Cum Uncis, 15 parts of Radix Dipsaci, 10 parts of Cortex Moutans, 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Rhizoma Corydalis, 6 parts of Ramulus Cinnamomi, 15 parts of Radix Puerariaes, 15 parts of Herba Leonuris.
The method for preparing of this medicine is following: at first take by weighing each raw material according to above-mentioned weight portion, and subsequent use; Then all raw materials are soaked in water, cover powder 2cm with water and be advisable; After being soaked in water 15 minutes, boil with high heat, 15 minutes at a simmer, cross leaching filtrating, promptly get the medicine of said treatment dysmenorrhea.
Embodiment 2: a kind of medicine of treating dysmenorrhea; It comprises the raw material of following weight portion: 15 parts of Rhizoma Cyperis, 15 parts in Poria, 15 parts of Oletum Trogopteroris, 15 parts of Pollen Typhae carbon, 18 parts of Radix Achyranthis Bidentataes, 11 parts of Pericarpium Citri Reticulataes, 30 parts of Ramulus Uncariae Cum Uncis, 30 parts of Radix Dipsaci, 16 parts of Cortex Moutans, 12 parts of Radix Salviae Miltiorrhizaes, 18 parts of Rhizoma Corydalis, 8 parts of Ramulus Cinnamomi, 20 parts of Radix Puerariaes, 18 parts of Herba Leonuris.
The method for preparing of this medicine is following: at first take by weighing each raw material according to above-mentioned weight portion, and subsequent use; Then all raw materials are soaked in water, cover powder 3cm with water and be advisable; After being soaked in water 30 minutes, boil with high heat, 20 minutes at a simmer, cross leaching filtrating, promptly get the medicine of said treatment dysmenorrhea.
Embodiment 3: a kind of medicine of treating dysmenorrhea; It comprises the raw material of following weight portion: 12 parts of Rhizoma Cyperis, 12 parts in Poria, 12 parts of Oletum Trogopteroris, 12 parts of Pollen Typhae carbon, 15 parts of Radix Achyranthis Bidentataes, 9 parts of Pericarpium Citri Reticulataes, 20 parts of Ramulus Uncariae Cum Uncis, 20 parts of Radix Dipsaci, 12 parts of Cortex Moutans, 10 parts of Radix Salviae Miltiorrhizaes, 16 parts of Rhizoma Corydalis, 7 parts of Ramulus Cinnamomi, 13 parts of Radix Puerariaes, 12 parts of Herba Leonuris.
The method for preparing of this medicine is following: at first take by weighing each raw material according to above-mentioned weight portion, and subsequent use; Then all raw materials are soaked in water, cover powder 2cm with water and be advisable; After being soaked in water 20 minutes, boil with high heat, 15 minutes at a simmer, cross leaching filtrating, promptly get the medicine of said treatment dysmenorrhea.
Embodiment 4: a kind of medicine of treating dysmenorrhea; It comprises the raw material of following weight portion: 10 parts of Rhizoma Cyperis, 10 parts in Poria, 10 parts of Oletum Trogopteroris, 10 parts of Pollen Typhae carbon, 10 parts of Radix Achyranthis Bidentataes, 6 parts of Pericarpium Citri Reticulataes, 15 parts of Ramulus Uncariae Cum Uncis, 15 parts of Radix Dipsaci, 10 parts of Cortex Moutans, 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Rhizoma Corydalis, 6 parts of Ramulus Cinnamomi, 15 parts of Radix Puerariaes, 15 parts of Herba Leonuris.
Above-mentioned each raw material is processed granule through the method for routine.
Embodiment 5: a kind of medicine of treating dysmenorrhea, it comprises the raw material of following weight portion: 10 parts of Rhizoma Cyperis, 10 parts in Poria, 10 parts of Oletum Trogopteroris, 10 parts of Pollen Typhae carbon, 10 parts of Radix Achyranthis Bidentataes, 10 parts of Cortex Moutans, 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Rhizoma Corydalis, 6 parts of Ramulus Cinnamomi, 15 parts of Herba Leonuris.
The method for preparing of this medicine is following: at first take by weighing each raw material according to above-mentioned weight portion, and subsequent use; Then all raw materials are soaked in water, cover powder 2cm with water and be advisable; After being soaked in water 15 minutes, boil with high heat, 15 minutes at a simmer, cross leaching filtrating, promptly get the medicine of said treatment dysmenorrhea.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2010105867359A CN102028842B (en) | 2010-12-14 | 2010-12-14 | Medicament for treating dysmenorrhea and preparation method thereof |
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| CN2010105867359A CN102028842B (en) | 2010-12-14 | 2010-12-14 | Medicament for treating dysmenorrhea and preparation method thereof |
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| CN102028842A CN102028842A (en) | 2011-04-27 |
| CN102028842B true CN102028842B (en) | 2012-03-14 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3335717A1 (en) * | 2016-12-13 | 2018-06-20 | Serelys Pharma S.A.M. | Composition for use in treating symptoms relating to premenstrual syndrome (pms) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579750B (en) * | 2012-02-29 | 2013-09-11 | 袁顺平 | Traditional Chinese medicine composition for treating primary dysmenorrhea |
| CN102698065B (en) * | 2012-06-13 | 2013-09-04 | 司秋荣 | Medicine composition for treating primary dysmenorrhea |
| CN102836259B (en) * | 2012-07-28 | 2014-02-05 | 陈双玲 | Menstruation regulating and pain relieving traditional Chinese medicine |
| CN105902784A (en) * | 2016-06-15 | 2016-08-31 | 林二洪 | Traditional Chinese medicine composition for treating qi and blood deficiency type dysmenorrhea |
| CN108404035A (en) * | 2018-05-24 | 2018-08-17 | 王传奇 | The Chinese medicine preparation of invigorate blood circulation network |
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| CN1651033A (en) * | 2005-01-14 | 2005-08-10 | 北京师范大学 | A traditional Chinese medicine composition for treating gynecological diseases and its preparation method |
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| CN101897930A (en) * | 2010-07-15 | 2010-12-01 | 重庆市南川区瑞丰农业开发有限责任公司 | Chinese medicinal herb for treating dysmenorrhoea disease |
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Patent Citations (3)
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| CN1651033A (en) * | 2005-01-14 | 2005-08-10 | 北京师范大学 | A traditional Chinese medicine composition for treating gynecological diseases and its preparation method |
| CN1994453B (en) * | 2006-12-28 | 2010-10-06 | 王玉秀 | Orally administered Chinese medicine for treating dysmenorrheal caused by qi stagnation and blood stasis |
| CN101897930A (en) * | 2010-07-15 | 2010-12-01 | 重庆市南川区瑞丰农业开发有限责任公司 | Chinese medicinal herb for treating dysmenorrhoea disease |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3335717A1 (en) * | 2016-12-13 | 2018-06-20 | Serelys Pharma S.A.M. | Composition for use in treating symptoms relating to premenstrual syndrome (pms) |
| WO2018108879A1 (en) * | 2016-12-13 | 2018-06-21 | Sérélys Pharma S.A.M. | Composition for use in treating dysphoria, depression and/or mood swings relating to premenstrual syndrome (pms) |
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