CN101804189B - Drug for treating primary dysmenorrhea - Google Patents

Drug for treating primary dysmenorrhea Download PDF

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Publication number
CN101804189B
CN101804189B CN201010149096XA CN201010149096A CN101804189B CN 101804189 B CN101804189 B CN 101804189B CN 201010149096X A CN201010149096X A CN 201010149096XA CN 201010149096 A CN201010149096 A CN 201010149096A CN 101804189 B CN101804189 B CN 101804189B
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parts
radix
drug
rhizoma
dysmenorrhea
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CN101804189A (en
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王亚丽
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王亚丽
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Abstract

The invention discloses a drug for treating primary dysmenorrhea, consisting of branch root of Chinese angelica, nutgrass galingale rhizome, sappan wood, suberect spatholobus stem, peach seed, rhizoma corydalis, red paeony root, ginger, pseudo-ginseng, Chinese mugwort leaf, hawthorn fruit, turmeric root-tuber, cassia twig and flos caryophyllata. The drug for treating primary dysmenorrheal has obvious curative effect and no toxic and side effect.

Description

The medicine of treatment primary dysmenorrhea
Technical field
The present invention relates to a kind of Chinese herbal medicine for the treatment of primary dysmenorrhea.
Background technology
Primary dysmenorrhea is a common gynecological disease.Primary dysmenorrhea is meant that the genitals does not have organic disease, is called primary dysmenorrhea again.According to investigations, the incidence rate of primary dysmenorrhea accounts for 36.06% of dysmenorrhea.What have a strong impact on work and study accounts for 13.59%.To its treatment, doctor trained in Western medicine is emphasized pain relieving, calmness, and the nonsteroidal anti inflammatory medicine is the most frequently used Western medicine of treatment primary dysmenorrhea.Though rapid-action, erious adverse reaction, curative effect is difficult to lastingly.The effect of the existing quick-acting antalgesic of treatment by Chinese herbs dysmenorrhea, the effect that has the dysmenorrhea of preventing to show effect once more again.
Summary of the invention
The medicine that the purpose of this invention is to provide a kind of therapeutic effect good curing primary dysmenorrhea.
Medical material in the raw material of the present invention is formed and the weight portion proportioning is:
Radix Angelicae Sinensis 5-15 part, Rhizoma Cyperi 20-40 part, Lignum Sappan 5-15 part, Caulis Spatholobi 10-20 part,
Semen Persicae 5-15 part, Rhizoma Corydalis 10-20 part, Radix Paeoniae Rubra 5-15 part, Rhizoma Zingiberis Recens 10-15 part,
Radix Notoginseng 5-25 part, Folium Artemisiae Argyi 5-12 part, Fructus Crataegi 10-20 part, Radix Curcumae 3-9 part,
Ramulus Cinnamomi 3-9 part and Flos Caryophylli 3-9 part.
The weight portion proportion optimization that medical material in the raw material is formed is:
10 parts of Radix Angelicae Sinensis, 30 parts of Rhizoma Cyperis, 10 parts of Lignum Sappans, 10 parts of Caulis Spatholobis,
10 parts in Semen Persicae, 15 parts of Rhizoma Corydalis, 10 parts of Radix Paeoniae Rubra, 10 parts in Rhizoma Zingiberis Recens,
10 parts of Radix Notoginseng, 6 parts of Folium Artemisiae Argyis, 10 parts of Fructus Crataegis, 6 parts of Radix Curcumaes,
6 parts of 6 parts of Ramulus Cinnamomi and Flos Caryophyllis.
Preparation method of the present invention:
Take by weighing Radix Angelicae Sinensis, Rhizoma Cyperi, Lignum Sappan, Caulis Spatholobi, Semen Persicae, Rhizoma Corydalis, Radix Paeoniae Rubra, Rhizoma Zingiberis Recens, Folium Artemisiae Argyi, Fructus Crataegi, Radix Curcumae, Ramulus Cinnamomi and Flos Caryophylli by weight ratio, add 500 milliliters of slow fire of water and fry in shallow oil half an hour slowly, get supernatant.Other gets Radix Notoginseng 10 grams and is ground into fine powder, and other wraps stand-by.
Using method of the present invention:
A few days ago begin to take in each menstrual cycle, potion clear water decoction every day, sooner or later respectively once.Get the supernatant Radix Notoginseng powder of taking after mixing it with water when taking, serve on five days and get final product.
Solution of the present invention is based on motherland's medical science to primary dysmenorrhea and pathogenetic understanding and Therapeutic Principle, with reference to modern pharmacological research achievement, carries out the brand-new prescription of Chinese herbal medicine by theory of Chinese medical science, realizes the effective treatment to primary dysmenorrhea.
In the Chinese prescription of the present invention, Radix Angelicae Sinensis is warm in nature, sweet in the mouth, suffering, but circulation of qi promoting enrich blood, promoting blood circulation to restore menstrual flow is monarch drug; Rhizoma Cyperi property is flat, hot, and mildly bitter flavor, little sweet is the Directorate-General DG of disorder of QI, but promoting QI circulation for relieving depression, and menstruction regulating and pain relieving is monarch drug; Lignum Sappan property is flat, sweet in the mouth, salty, can separate the blood and dissolving stasis pain relieving and stimulate the menstrual flow, and is ministerial drug; Caulis Spatholobi is warm in nature, bitter in the mouth, sweet, but promoting tissue regeneration by removing blood stasis, and fluent passages through which vital energy circulates is ministerial drug; Semen Persicae is flat, bitter in the mouth, sweet, but blood circulation promoting and blood stasis dispelling is ministerial drug; Rhizoma Corydalis is warm in nature, acrid in the mouth, hardship, and the promoting the circulation of QI pain relieving of can invigorating blood circulation is ministerial drug; Radix Paeoniae Rubra cold nature, bitter in the mouth, but promoting blood circulation to remove blood stasis are ministerial drug; Rhizoma Zingiberis Recens slightly warm in nature, acrid in the mouth, it is capable to promote blood, is messenger drug; Radix Notoginseng is warm in nature, sweet in the mouth, little hardship, but the dissipating blood stasis analgesic therapy can lead to and can mend, be ministerial drug; Folium Artemisiae Argyi is warm in nature, bitter in the mouth, suffering, but the dispelling cold by warming the meridian pain relieving is messenger drug; Fructus Crataegi is warm in nature, sour in the mouth, sweet, but the circulation of qi promoting dissipating blood stasis is adjuvant drug; Radix Curcumae is cold in nature, bitter in the mouth, suffering, but regulating qi to disperse stagnation is adjuvant drug; Ramulus Cinnamomi is warm in nature, sweet in the mouth, suffering, but warming the meridian and promoting blood circulation, and dispersing cold for relieving pain is messenger drug; Warm in nature, the acrid in the mouth of Flos Caryophylli, but warming spleen and stomach for dispelling cold pain relieving are adjuvant drug., assist a ruler in governing a country mutually through dialectical prescription, organic compatibility with above-mentioned 14 flavor Chinese herbal medicine, can reach the effect that promoting flow of QI and blood, blood stasis dispelling cold expelling, pain relieving stimulate the menstrual flow, thereby realize the purpose of treatment primary dysmenorrhea.
The acute toxicity test of Chinese prescription of the present invention
One, experiment material
Animal: Kunming mouse is provided by laboratory animal room of the Capital University of Medical Sciences, and body weight is 18~22g.
Medicine: this Chinese prescription with distilled water slow fire fry in shallow oil slowly concentrate after half an hour standby.
Two, method:
Mtd test
20 of female mices, experiment the previous day, water is can't help in fasting overnight, under the condition of 20 ± 2 ℃ of room temperatures, gastric infusion twice in 24 hours, dosage is 15.0g/Kg, observes a week after the administration.
Mice in 30 minutes, because the administration volume is bigger than normal, has discomfort slightly after administration as a result, and it shows as mice and has loose bowels, back of a bow phenomenon recovers normal subsequently rapidly, and quiet, observes for two weeks continuously, mice all survives, and cuts open inspection, and naked eyes examine main inner internal organs, no abnormality seen.
Three, conclusion:
According to the requirement of Chinese medicine toxicological study, can accept maximum volume under the Cmax mice, carry out mtd test.Mice is all survivals in the observation period, do not see overt toxicity, show that this poison of drug is very little, and is clinical safe in utilization.
The clinical research data of prescription of the present invention
1. physical data
Selected 180 routine cases are and are diagnosed as the patient of primary dysmenorrhea at my gate year January in January, 2007 to 2009, and the age is between 13 years old one 42 years old.48 examples within the course of disease 1 year, 1-2 45 examples, 2-4 66 examples, 21 examples more than 4 years.Normal substantially 138 examples of menstrual cycle, period staggering 42 examples.The dysmenorrhea time is many to be main in first and second sky of menstrual onset.Once treated with Chinese and western drugs mostly, poor effect, the dysmenorrhea symptom does not improve.
2. diagnostic criteria
" the clinical research guideline of treatment by Chinese herbs dysmenorrhea " of standard reference bureau of drug administration of Ministry of Health of the People's Republic of China formulation in 1993.The women is all before and after pass through or menstrual period occur hypogastralgia, weigh down and expand, companion's soreness of waist or other discomforts, and degree is heavier so that influence the live and work quality, and the genitals does not have organic disease person on inspection.Get rid of the case standard: be secondary dysmenorrhea person after diagnosing.
3. dysmenorrhea degree standard: " the clinical research guideline of treatment by Chinese herbs dysmenorrhea " formulated according to bureau of drug administration of Ministry of Health of the People's Republic of China in 1993
Slightly: in menstrual period or obvious through front and back lower abdomen pain, companion's waist is ached, but can adhere to work, and no General Symptoms need be obeyed analgesic sometimes.The dysmenorrhea symptom integral is below 8 minutes.
Moderate: lower abdomen pain accompanies waist to ache unbearably before and after menstrual period or menstrual period, and nausea and vomiting, extremity are not warm, postpones with pain relieving measure pain.The dysmenorrhea symptom integral is at the 8-13.5 branch.
Severe: feel restless in menstrual period or unbearably, have a strong impact on work and study or daily life, must lie up through front and back lower abdomen pain, ache with waist, complexion white, dripping cold sweat, extreme cold of the limbs, the vomiting abdomen is cold, or rectal tenesmus, adopts the pain relieving measure not have obvious alleviation.The dysmenorrhea symptom integral is more than 14 minutes.
Observation index; Adopt " the clinical research guideline of treatment by Chinese herbs dysmenorrhea " observation index as Comparison of therapeutic and the fractionated observation index of dysmenorrhea light and heavy degree before and after the treatment.
4. Therapeutic Method
Each menstrual cycle a few days ago begin treatment of hanging oneself.Every day, potion was decocted in water for oral dose, every day 2 times, and logotype five days, treating 3 menstrual cycle continuously is 1 course of treatment.
5. clinical efficacy
5.1 efficacy assessment standard
Formulate according to " the clinical research guideline of new Chinese medicine treatment dysmenorrhea " in Ministry of Health of the People's Republic of China's " new Chinese medicine clinical research guideline ":
Recent clinical cure: take medicine back stomachache and other transference cure, 3 menstrual cycle of drug withdrawal do not recur, and pain degree recovers 0 fen person.
Produce effects: stomachache obviously alleviates, and all the other transference cures or alleviate refuse to obey that analgesic can adhere to work, and pain degree is reduced to below 1/2 of integration of treatment for the treatment integration.
Effectively: stomachache alleviates, and all the other symptoms take a turn for the better, and the clothes analgesic can be adhered to work; Pain degree is reduced to preceding below 1/3 of integration of treatment for treatment back integration.
Invalid: stomachache and other symptom do not have the changer.
5.2 therapeutic outcome:
In order to 3 menstrual cycle of last scheme treatment, treat 180 routine dysmenorrhea patients, cure rate 80.00%, effective percentage 96.67%.Follow up a case by regular visits to 1 year dysmenorrhea and do not recur, the treatment situation sees the following form:
Calibration The example number Cure Produce effects Effectively Invalid Effective percentage
Slightly 72 66 6 0 0 100%
Moderate 78 63 6 6 3 96.15%
Severe 30 15 6 6 3 90.00%
Add up to 180 144 18 12 6 96.67%
Clinical research is the result show: evident in efficacy with prescription therapeutic primary dysmenorrhea of the present invention, and have no side effect.
The specific embodiment
The following examples can make those skilled in the art more fully understand the present invention, but do not limit the present invention in any way.
Embodiment 1
Take by weighing each crude drug by following weight proportion:
Radix Angelicae Sinensis 10g, Rhizoma Cyperi 30g, Lignum Sappan 10g, Caulis Spatholobi 10g,
Semen Persicae 10g, Rhizoma Corydalis 15g, Radix Paeoniae Rubra 10g, Rhizoma Zingiberis Recens 10g,
Ramulus Cinnamomi 6g, Folium Artemisiae Argyi 6g, Fructus Crataegi 10g, Radix Curcumae 6g and Flos Caryophylli 6g,
Add 500 milliliters of slow fire of water and fry in shallow oil half an hour slowly, get supernatant.Other gets Radix Notoginseng 10 grams and is ground into fine powder, and other wraps stand-by.
Using method: a few days ago begin to take in each menstrual cycle, potion clear water decoction every day, sooner or later respectively once.Get the supernatant Radix Notoginseng powder of taking after mixing it with water when taking, serve on five days and get final product.
Embodiment 2
Take by weighing each crude drug by following weight proportion:
Radix Angelicae Sinensis 5g, Rhizoma Cyperi 40g, Lignum Sappan 5g, Caulis Spatholobi 20g,
Semen Persicae 5g, Rhizoma Corydalis 20g, Radix Paeoniae Rubra 5g, Rhizoma Zingiberis Recens 15g,
Ramulus Cinnamomi 3g, Folium Artemisiae Argyi 12g, Fructus Crataegi 10g, Radix Curcumae 9g and Flos Caryophylli 3g,
Add 500 milliliters of slow fire of water and fry in shallow oil half an hour slowly, get supernatant.Other gets Radix Notoginseng 5-25 gram and is ground into fine powder, and other wraps stand-by.
Embodiment 3
Take by weighing each crude drug by following weight proportion:
Radix Angelicae Sinensis 15g, Rhizoma Cyperi 20g, Lignum Sappan 15g, Caulis Spatholobi 10g,
Semen Persicae 15g, Rhizoma Corydalis 10g, Radix Paeoniae Rubra 15g, Rhizoma Zingiberis Recens 10g,
Ramulus Cinnamomi 9g, Folium Artemisiae Argyi 5g, Fructus Crataegi 20g, Radix Curcumae 3g and Flos Caryophylli 9g,
Add 500 milliliters of slow fire of water and fry in shallow oil half an hour slowly, get supernatant.Other gets Radix Notoginseng 5-25 gram and is ground into fine powder, and other wraps stand-by.

Claims (2)

1. medicine for the treatment of primary dysmenorrhea is characterized in that medical material in the raw material is formed and the weight portion proportioning is:
Radix Angelicae Sinensis 5-15 part, Rhizoma Cyperi 20-40 part, Lignum Sappan 5-15 part, Caulis Spatholobi 10-20 part, Semen Persicae 5-15 part, Rhizoma Corydalis 10-20 part, Radix Paeoniae Rubra 5-15 part, Rhizoma Zingiberis Recens 10-15 part, Radix Notoginseng 5-25 part, Folium Artemisiae Argyi 5-12 part, Fructus Crataegi 10-20 part, Radix Curcumae 3-9 part, Ramulus Cinnamomi 3-9 part and Flos Caryophylli 3-9 part.
2. according to the medicine of the described treatment primary dysmenorrhea of claim 1, it is characterized in that medical material composition and the weight portion proportioning in the raw material is:
6 parts of 10 parts of Radix Angelicae Sinensis, 30 parts of Rhizoma Cyperis, 10 parts of Lignum Sappans, 10 parts of Caulis Spatholobis, 10 parts in Semen Persicae, 15 parts of Rhizoma Corydalis, 10 parts of Radix Paeoniae Rubra, 10 parts in Rhizoma Zingiberis Recens, 10 parts of Radix Notoginseng, 6 parts of Folium Artemisiae Argyis, 10 parts of Fructus Crataegis, 6 parts of Radix Curcumaes, 6 parts of Ramulus Cinnamomi and Flos Caryophyllis.
CN201010149096XA 2010-04-14 2010-04-14 Drug for treating primary dysmenorrhea Expired - Fee Related CN101804189B (en)

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Publication number Priority date Publication date Assignee Title
CN102688458B (en) * 2012-06-10 2013-09-25 李百荣 Chinese medicament for treating primary dysmenorrhea
CN105126044A (en) * 2015-10-28 2015-12-09 王淑英 Medicine for treating primary dysmenorrheal
CN105497389A (en) * 2016-01-31 2016-04-20 济南新时代医药科技有限公司 Traditional Chinese medicine for treating primary dysmenorrhea
CN111494347A (en) * 2020-04-12 2020-08-07 沈阳促晋科技有限公司 Traditional Chinese medicine plaster for treating dysmenorrhea and preparation method thereof

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CN100490891C (en) * 2006-06-13 2009-05-27 厦门桂龙投资管理有限公司 Medicine composition for treating dysmenorrhea and its preparation process

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