CN111671849A

CN111671849A - Full-ingredient formula of fire-clearing toothache-eliminating granules for treating periodontitis and preparation method thereof

Info

Publication number: CN111671849A
Application number: CN202010671287.6A
Authority: CN
Inventors: 刘世军
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-07-13
Filing date: 2020-07-13
Publication date: 2020-09-18

Abstract

The invention provides a full ingredient formula of a granule for clearing away fire and relieving toothache for treating periodontitis and a preparation method thereof, wherein the granule comprises full ingredient extract raw materials prepared from Chinese herbal medicine decoction pieces in parts by mass as follows: the traditional Chinese medicine preparation for treating a series of uncomfortable symptoms of periodontal pain, bleeding and red and swollen gums is invented according to the traditional Chinese medicine theory and the therapeutic medication principle of China, solves the problem that the western medicine lacks medicines for treating related clinical symptoms except for the operation method, and greatly reduces the discomfort of a patient; clearing heat of viscera and stomach, nourishing yin, treating both principal and secondary aspect of disease, recovering the body function to be normal, embodying the overall view of treatment based on syndrome differentiation of traditional Chinese medicine, and the treatment concept of treating diseases based on human is not based on diseases.

Description

Full-ingredient formula of fire-clearing toothache-eliminating granules for treating periodontitis and preparation method thereof

Technical Field

The invention relates to the technical field of a formula for treating periodontitis and a preparation method thereof, in particular to a full-ingredient formula of a fire-clearing toothache-eliminating granule for treating periodontitis and a preparation method thereof.

Background

Periodontitis is a common oral disease, buried in the tissues surrounding the teeth (including the gingiva, periodontal ligament, alveolar bone), and known as the "number one killer" of oral health. Its early symptoms are not severe and patients are easily overlooked. Once symptoms such as gingival bleeding, pus discharge, gingival atrophy and swelling and pain, tooth root exposure, excessive tartar, halitosis, tooth loosening, elongation, displacement and pain occur, the attention of patients is paid. If periodontitis is not timely eliminated, most teeth are easy to infect and fall off and even involve full teeth. The symptoms of periodontitis are mainly manifested as redness, swelling and bleeding of the gums, bleeding not only during tooth brushing but also during speaking or biting hard objects, dark red gums, and bright due to edema. In addition, pockets are formed, which normally are only zero to two millimeters deep in the gingival sulcus where the gingiva attaches to the tooth, and more than two millimeters. The formation of the periodontal pocket indicates that inflammation has progressed from the gingiva to the periodontal supporting tissue, allowing deeper periodontal tissues to become infected, chronically destroyed, and purulent secretions to escape from the periodontal pocket. In early stage, periodontitis is not loose in teeth, and only when chronic destructive inflammation develops to a certain extent and periodontal tissue supporting force is greatly weakened, tooth loosening can be caused. The traditional Chinese medicine considers that teeth are mainly controlled by kidneys, deficiency of kidney essence and blood lack, and loss of nourishment of the teeth cause flaccidity of bones, and yin deficiency and fire excess cause the deficient fire to be flaming up to gum and flesh, and teeth shake and root dew after a long time; or the disease is caused by body weakness, or consumption of healthy qi due to prolonged illness, deficiency of qi and blood, and loss of nourishment of gum, so that pathogenic factors enter the gum due to deficiency, so that gum and flesh atrophy, blood does not flow through channels, and gum bleeding occurs. Therefore, the medicine for treating periodontitis can prevent tooth loosening and early tooth loss, and has great significance.

Disclosure of Invention

In order to solve the problems, the invention provides a full ingredient formula of a fire-clearing toothache-eliminating granule for treating periodontitis and a preparation method thereof, which solves the problem that western medicine lacks medicines for treating relevant clinical symptoms except for an operation method, and greatly reduces discomfort of patients; clear heat of viscera and stomach, nourish yin, treat both manifestation and root cause of disease and restore the normal function of the organism.

The technical scheme of the invention is as follows: the full-ingredient formula of the fire-clearing toothache-eliminating granules for treating periodontitis and the preparation method thereof are provided, and the full-ingredient formula comprises the following full-ingredient extract raw materials prepared from Chinese herbal medicine decoction pieces in parts by mass:

further, the preparation method comprises the following steps:

s1, weighing the raw materials of the extracts of gypsum, radix rehmanniae, radix ophiopogonis, rhizoma anemarrhenae, radix cyathulae, coptis, scutellaria, phellodendron, ligusticum wallichii, radix angelicae, schizonepeta, radix sileris and liquorice according to the formula amount;

s2, respectively carrying out character, identification, moisture and infrared spectrum inspection on the components, and carrying out the next step after the components are qualified;

s3, sequentially putting the raw materials qualified in the step S2 into a grinder for grinding, sieving the ground materials with a 40-mesh sieve, and collecting all ground fine powder particles;

s4, taking the fine powder particles of the materials obtained in the step S3, and putting the fine powder particles of the materials into a stirring container in sequence to be fully and uniformly mixed to obtain a total mixed granular preparation;

and S5, packaging the prepared particles by using an aluminum-plastic composite film. And checking to be qualified to obtain a finished product. Three doses are taken in one day with warm water.

Compared with the prior art, the invention has the beneficial effects that: the traditional Chinese medicine preparation for treating a series of uncomfortable symptoms of periodontal pain, bleeding and gingival swelling is invented according to the traditional Chinese medicine theory and the therapeutic medication principle of China, the situation that medicines for treating related clinical symptoms are lacked except for an operation method in western medicine is solved, and the discomfort of a patient is greatly reduced; clearing heat of viscera and stomach, nourishing yin, treating both principal and secondary aspect of disease, recovering the body function to be normal, embodying the overall view of treatment based on syndrome differentiation of traditional Chinese medicine, and the treatment concept of treating diseases based on human is not based on diseases.

Drawings

The invention is further illustrated below with reference to the figures:

FIG. 1 is a schematic flow diagram of the present invention;

Detailed Description

The present invention will be described in further detail with reference to the drawings, which are only for explaining the present invention and are schematic illustrations of the embodiments of the present invention, and should not be construed as limiting the present invention.

As shown in figure 1, the full ingredient formula of the fire-clearing toothache-eliminating granule for treating periodontitis and the preparation method thereof comprise full ingredient extract raw materials prepared from the following Chinese herbal medicine decoction pieces in parts by mass:

further, the preparation method comprises the following steps:

The recipe is prepared by decocting famous prescription jade lady from Jingyue quan Shu, and is mainly used for treating stomach heat yin deficiency syndrome. Headache, toothache, loose teeth, gingival bleeding, dysphoria with smothery sensation, thirst, red tongue with yellow and dry coating. It is also indicated for diabetes, food depletion and hunger.

The prescription is as follows: this syndrome is mostly caused by excessive yang-qi and fire consuming stomach heat damaging yin essence, and mainly treats stomach heat and kidney yin nourishing. The yang-qi-fire will go upward to the head and face and enter the upper teeth, and the stomach-heat will go upward along the meridians, resulting in headache and toothache; gingival bleeding due to heat injury to stomach meridian and blood collaterals; heat consumption is low, yin and yin essence are reduced, so that dysphoria with smothery sensation and thirst are seen; the red tongue with yellow and dry coating is the symptom of yin deficiency. In the recipe, Gypsum Fibrosum, with its pungent, sweet and cold properties, is used as the monarch drug for clearing stomach fire. Dried rehmannia root, radix rehmanniae has the effects of nourishing yin and clearing heat and nourishing kidney water, so it is used as a ministerial drug. Monarch and minister are compatible, clear fire and strengthen water, and take deficiency and excess into consideration. The rhizoma anemarrhenae is bitter and cold, has moistening property and has the function of nourishing and clearing, helps gypsum to clear stomach heat and relieve polydipsia, and helps rehmannia root to nourish kidney yin; radix Ophiopogonis is slightly bitter, sweet and cold, and helps radix rehmanniae Preparata to nourish kidney and moisten stomach dryness, and has the effects of clearing heart fire and relieving restlessness, and the two are used as adjuvant drugs. Niu xi is an adjuvant drug for directing heat and blood downward, tonifying liver and kidney, and reducing fire of inflammation and stopping bleeding. The coptis root can clear heart fire, the phellodendron can clear ministerial fire, the scutellaria can clear liver fire, the effect of gypsum on clearing fire is assisted, the ligusticum wallichii and the angelica dahurica can promote menstruation to relieve headache, the schizonepeta, the divaricate saposhnikovia root can disperse wind-heat, the liquorice can detoxify and harmonize the other drugs. The medicines are combined to clear heat and nourish yin, the fire is purged and the wind is dispersed, the deficiency and excess are treated simultaneously, the excess is treated mainly, the stomach heat is cleared, the kidney water is supplemented, and the diseases can be cured.

The formula is a heat clearing agent and has the effects of clearing heat in viscera, stomach and yin.

Example one

The method comprises the following steps of preparing the following total-component extract raw materials by using the Chinese herbal medicine decoction pieces in parts by mass:

s1, weighing raw materials of the whole-component extract, namely 0.5g of gypsum, 4.0g of radix rehmanniae, 4.0g of radix ophiopogonis, 1.0g of rhizoma anemarrhenae, 1.0g of radix cyathulae, 0.5g of coptis chinensis, 0.5g of scutellaria baicalensis, 0.5g of cortex phellodendri, 1.2g of ligusticum wallichii, 0.6g of radix angelicae, 0.45g of schizonepeta, 0.3g of radix sileris and 0.6g of liquorice;

Case 1, Zhang xx, male, 40 years old, chief complaint about repeated swelling and pain of left posterior teeth for more than a month, accompanied by bad breath, left toothache involving left headache, constipation, vexation, dry mouth, red tongue, yellow and greasy tongue coating, wiry pulse, examination of left gum redness and swelling, left upper 4 far-middle occlusal caries, probing (+) cold and hot diagnosis (+) gingival position with fistula, no tooth loosening, diagnosis of chronic pulpitis, chronic periodontitis. The treatment is carried out after anti-inflammatory treatment, the symptoms are caused by stomach heat and yin deficiency, the treatment is carried out after oral administration of the fire-clearing toothache-eliminating granules, the toothache disappears after seven days, the halitosis and the constipation symptoms are all relieved, and finally root canal treatment is carried out.

Case 2. Liu xx, female, age 59, chief complaints: toothache for half a month, gingival bleeding, halitosis, dry mouth, constipation, red tongue with yellow and thick coating, wiry and rapid pulse, inspection: calculus (+), dark red gum, thickened gingival margin, round gingival papilla, probing bleeding and unobvious tooth tapping pain. The medicine is used for diagnosing gingivitis, which belongs to stomach fire yin deficiency syndrome, and the medicine is orally administered with 7 pairs of granules for clearing fire, toothache and further for cleaning periodontal.

Case 3. Yang xx, male, 49 years old complain about right side back tooth swelling and pain for one week, accompanied by bad breath, constipation, vexation, dry mouth, thirst, red tongue, yellow and greasy tongue coating, wiry pulse, examination of red and swollen right gum, caries in the upper right 4 far middle, probing (+) cold and hot diagnosis (+) gum has a fistula, no tooth loose, diagnosis of chronic pulpitis, chronic periodontitis. The treatment is carried out after anti-inflammatory treatment, the symptoms are caused by stomach heat and yin deficiency, the treatment is carried out after oral administration of the fire-clearing toothache-eliminating granules, the toothache disappears after seven days, the halitosis and the constipation symptoms are all relieved, and finally root canal treatment is carried out.

Example 2

s1, weighing raw materials of the whole extract, namely 0.3g of gypsum, 3g of radix rehmanniae, 3g of radix ophiopogonis, 0.8g of rhizoma anemarrhenae, 0.8g of radix cyathulae, 0.3g of coptis chinensis, 0.3g of scutellaria baicalensis, 0.3g of golden cypress, 1.0g of ligusticum wallichii, 0.4g of radix angelicae, 0.3g of schizonepeta, 0.2g of radix sileris and 0.4g of liquorice;

Case 1, Zhao xx, male, 37 years old, because of the left lower side caries with pulpitis gall for a week, oral antipyretic toothache-eliminating granule low dose 2 times a day, 1 bag each time, seven days pain disappearance, 10 days after swelling elimination.

Case 2, Xuxx, female, age 70, oral antipyretic toothache eliminating granule for treating pulpitis and pain due to caries on right lower side, 2 times a day, 1 bag each time, five days of pain disappearance, and swelling elimination after one week.

In case 3, Sunxx, male and 42 years old, oral fire-clearing toothache-eliminating granule for treatment of dental caries with pulpitis on the lower right side is taken 2 times a day, 1 bag each time, and the pain disappears after five days and is healed in one week.

Example 3

s1, weighing raw materials of the whole-component extract, namely 0.7g of gypsum, 5g of radix rehmanniae, 5g of radix ophiopogonis, 1.2g of rhizoma anemarrhenae, 1.2g of radix cyathulae, 0.7g of coptis chinensis, 0.7g of scutellaria baicalensis, 0.7g of golden cypress, 1.4g of ligusticum wallichii, 0.8g of radix angelicae, 0.6g of schizonepeta, 0.5g of radix sileris and 0.8g of liquorice;

Symptoms and signs	Tooth pain	Redness and swelling of gum	Bleeding of gum	Halitosis	Headache (headache)	Constipation
							Number of observations	90	88	85	85	95	65
Is remarkable in that	85	80	70	80	90	61
							Mitigation of	5	8	15	5	5	4
Invalidation	0	0	0	0	0	0

TABLE 1100 self-describing therapeutic situation statistics

Description of the drawings: "significant" means disappearance or apparent improvement of symptoms;

"reduced" means a relief of symptoms, but with modest efficacy;

"invalid" means that there is no effect.

And (4) comprehensive conclusion:

the obvious effect rate on toothache reaches 94.4 percent;

the significant rate of the gum for red and swollen gum reaches 94.1 percent;

the significant rate of the medicine for treating gingival bleeding reaches 82.3 percent

The effect on halitosis is that the remarkable rate reaches 90.9%;

for the effect of headache, the significant rate is 94.7%;

the remarkable rate of the effect on constipation reaches 93.8 percent;

based on no ineffective cases, the effective rate of the method for consolidating the constitution reaches 100 percent.

The invention discloses a traditional Chinese medicine preparation for treating a series of uncomfortable symptoms of periodontal pain, bleeding and gingival swelling according to the traditional Chinese medicine theory and the therapeutic medication principle in China, solves the problem that the western medicine lacks medicines for treating relevant clinical symptoms except for an operation method, and greatly reduces the discomfort of a patient; clearing heat of viscera and stomach, nourishing yin, treating both principal and secondary aspect of disease, recovering the body function to be normal, embodying the overall view of treatment based on syndrome differentiation of traditional Chinese medicine, and the treatment concept of treating diseases based on human is not based on diseases.

The above description is illustrative of the present invention and is not to be construed as limiting thereof, as numerous modifications and variations therein will be apparent to those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present invention should be included in the scope of the claims of the present invention.

Claims

1. The fire-clearing toothache relieving granule full ingredient formula for treating periodontitis is characterized by comprising full ingredient extract raw materials prepared from the following Chinese herbal medicine decoction pieces in parts by mass:

。

2. the full ingredient formula of the inflammation-relieving toothache-eliminating particle for treating periodontitis according to claim 1, wherein the preparation method comprises the following steps:

3. The full-ingredient formula of the inflammation-relieving toothache-eliminating particle for treating periodontitis according to claim 1, wherein the full-ingredient formula comprises the following components: the gypsum, the dried rehmannia root, the dwarf lilyturf tuber, the common anemarrhena rhizome, the medicinal cyathula root, the golden thread, the baical skullcap root, the amur corktree bark, the Szechuan lovage rhizome, the dahurian angelica root, the fineleaf schizonepeta herb, the divaricate saposhnikovia root and the liquoric root.