CN102552354A - Medicinal composition with antipyretic, anti-inflammatory and analgesic effects and preparation method thereof - Google Patents

Medicinal composition with antipyretic, anti-inflammatory and analgesic effects and preparation method thereof Download PDF

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CN102552354A
CN102552354A CN2012100280889A CN201210028088A CN102552354A CN 102552354 A CN102552354 A CN 102552354A CN 2012100280889 A CN2012100280889 A CN 2012100280889A CN 201210028088 A CN201210028088 A CN 201210028088A CN 102552354 A CN102552354 A CN 102552354A
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rhizoma
radix
component
parts
gypsum fibrosum
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不公告发明人
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SHENZHEN LIRUI MEDICAL TECHNOLOGY Co Ltd
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SHENZHEN LIRUI MEDICAL TECHNOLOGY Co Ltd
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Abstract

The invention discloses a medicinal composition with antipyretic, anti-inflammatory and analgesic effects and a preparation method thereof, and belongs to the field of Chinese medicines. The medicinal composition comprises the following Chinese herbal medicines in part by weight: 10 to 50 parts of gypsum serving as a monarch medicine and 5 to 15 parts of szechuan lovage rhizome serving as a minister medicine or 5 to 15 parts of szechuan lovage rhizome and 5 to 25 parts of angelica dahurica which serve as the minister medicine. The medicinal composition can be prepared into any common preparation for oral administration; and on the basis of the monarch medicine and the minister medicine, different adjuvant medicines are added according to the severe degree or duration of illness to exert a better curative effect. The medicinal composition has the obvious antipyretic, anti-inflammatory and analgesic effects, can be widely used for treating multiple diseases such as fever, inflammation and pain, is particularly suitable for treating diseases of fever and pain in heads and bodies which are caused by cold, dental ulcer or dental arthritis or various headaches and the like or diseases such as excessive heat in qi system of yangming, heat stagnation of yangming, deficiency fire of spleen and stomach, headaches and the like in traditional Chinese medical science, and has the characteristics of high efficiency, quick response, relapse prevention of the illness after medicine withdrawal and the like.

Description

A kind of pharmaceutical composition and preparation method thereof with analgesic, antiinflammatory and analgesic activity
The application is the dividing an application of application for a patent for invention of " a kind of pharmaceutical composition with analgesic, antiinflammatory and analgesic activity and preparation method thereof ", and original application day is 2008.03.25; Application number is: 200810065869.9.
[technical field]
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, belong to the field of Chinese medicines with analgesic, antiinflammatory and analgesic activity.
[background technology]
Flu is a kind of common disease, and heating is its cardinal symptom with head-body-pain, and doctor trained in Western medicine is thought and belonged to due to the viral infection more, but present antiviral drugs curative effect is very undesirable, and antipyretic analgesic commonly used is temporary transient controlling symptoms also, is difficult to thorough solution slight illness.Though the Chinese patent medicine preparation kind of treatment cold, fever is numerous, effective percentage is also very limited, and usually a few days must not rehabilitation for many patients.Oral ulcer, periodontitis, headache also are clinical common diseases, and the cause of disease of such disease is complicated, and pain is its important clinical symptom, but general analgesic, antiinflammatory and analgesic are only effective to patients with mild, and the severe patient is difficult to prove effective.Therefore urgent hope can have a kind of effective percentage high, and the state of an illness is difficult for repeatedly analgesic, antiinflammatory and analgesic and preparation method thereof after the drug withdrawal.
[summary of the invention]
The object of the present invention is to provide a kind of pharmaceutical composition with analgesic, antiinflammatory and analgesic activity.
Another purpose of the present invention provides a kind of preparation of drug combination method with analgesic, antiinflammatory and analgesic activity.
The crude drug of pharmaceutical composition of the present invention is: as Gypsum Fibrosum 10-50 part of monarch drug; With constitute ministerial drug as Rhizoma Chuanxiong 5-15 part of ministerial drug or by Rhizoma Chuanxiong 5-15 part and Radix Angelicae Dahuricae 5-25 part.
Preferred consumption is: 25 parts of Gypsum Fibrosum, 10 parts of Rhizoma Chuanxiongs; Or 25 parts of Gypsum Fibrosum, 10 parts of Rhizoma Chuanxiongs, 15 parts of the Radixs Angelicae Dahuricae.
The present invention also provides the method for preparing of this kind pharmaceutical composition active component, wherein:
When Rhizoma Chuanxiong and the Radix Angelicae Dahuricae were ministerial drug, this method for preparing comprised:
1) take by weighing each crude drug Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, subsequent use.
2) Rhizoma Chuanxiong, the Radix Angelicae Dahuricae of said proportioning added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 1.
3) Gypsum Fibrosum with said proportioning adds 8～15 times of water gagings decoctions 1～3 time, and each 1～3 hour, filtration merged all filtratings, is concentrated into relative density 1.05～1.15 (70～85 ℃ of hot surveys), leaves standstill, and filters, and it is concentrated, dry to filtrate, and gets component 2.
4) merge component 1 and component 2, will be ground into powder, mix homogeneously just has been prepared into the active component of medicine of the present invention.
Perhaps
When Rhizoma Chuanxiong was ministerial drug, this method for preparing comprised:
1) take by weighing each crude drug Gypsum Fibrosum, Rhizoma Chuanxiong, subsequent use.
2) Rhizoma Chuanxiong of said proportioning is added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 1.
3) Gypsum Fibrosum with said proportioning adds 8～15 times of water gagings decoctions 1～3 time, and each 1～3 hour, filtration merged all filtratings, is concentrated into relative density 1.05～1.15 (70～85 ℃ of hot surveys), leaves standstill, and filters, and it is concentrated, dry to filtrate, and gets component 2.
4) merge component 1 and component 2, will be ground into powder, mix homogeneously just has been prepared into the active component of medicine of the present invention.
The crude drug of pharmaceutical composition of the present invention can also be: as Gypsum Fibrosum 10-50 part of monarch drug; With constitute ministerial drug as Rhizoma Chuanxiong 5-15 part of ministerial drug or by Rhizoma Chuanxiong 5-15 part and Radix Angelicae Dahuricae 5-25 part; Rhizoma Cimicifugae 5-20 part, Radix Cyathulae or Radix Achyranthis Bidentatae 5-25 part as adjuvant drug.
Preferred consumption is: 25 parts of Gypsum Fibrosum, 10 parts of Rhizoma Chuanxiongs or by 15 parts of 10 parts of combination, the Rhizoma Cimicifugaes of 15 parts of 10 parts of Rhizoma Chuanxiongs and the Radixs Angelicae Dahuricae, Radix Cyathulae or Radix Achyranthis Bidentataes.
The present invention also provides the method for preparing of this kind pharmaceutical composition active component, wherein:
When Rhizoma Chuanxiong and the Radix Angelicae Dahuricae are ministerial drug, Radix Cyathulae or Radix Achyranthis Bidentatae when being adjuvant drug, this method for preparing comprises:
1) take by weighing each crude drug Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Cyathulae or Radix Achyranthis Bidentatae, subsequent use.
2) Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Cyathulae or the Radix Achyranthis Bidentatae of said proportioning added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 1.
3) Gypsum Fibrosum, the Rhizoma Cimicifugae with said proportioning adds 8～15 times of water gagings decoctions 1～3 time, and each 1～3 hour, filtration merged all filtratings, is concentrated into relative density 1.05～1.15 (70～85 ℃ of hot surveys), leaves standstill, and filters, and it is concentrated, dry to filtrate, and gets component 2.
4) merge component 1 and component 2, be ground into powder, mix homogeneously just has been prepared into the active component of medicine of the present invention.
Perhaps
When Rhizoma Chuanxiong is ministerial drug, Radix Cyathulae or Radix Achyranthis Bidentatae when being adjuvant drug, this method for preparing comprises:
1) take by weighing each crude drug Gypsum Fibrosum, Rhizoma Chuanxiong, Rhizoma Cimicifugae, Radix Cyathulae or Radix Achyranthis Bidentatae, subsequent use.
2) Rhizoma Chuanxiong, Radix Cyathulae or the Radix Achyranthis Bidentatae of said proportioning added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 1.
3) Gypsum Fibrosum, the Rhizoma Cimicifugae with said proportioning adds 8～15 times of water gagings decoctions 1～3 time, and each 1～3 hour, filtration merged all filtratings, is concentrated into relative density 1.05～1.15 (70～85 ℃ of hot surveys), leaves standstill, and filters, and it is concentrated, dry to filtrate, and gets component 2.
4) merge component 1 and component 2, be ground into powder, mix homogeneously just has been prepared into the active component of medicine of the present invention.
The crude drug of pharmaceutical composition of the present invention can also be: as Gypsum Fibrosum 10-50 part of monarch drug; With constitute ministerial drug as Rhizoma Chuanxiong 5-15 part of ministerial drug or by Rhizoma Chuanxiong 5-15 part and Radix Angelicae Dahuricae 5-25 part; Rhizoma Cimicifugae 5-20 part, Radix Cyathulae or Radix Achyranthis Bidentatae 5-25 part, Rhizoma Coptidis 1-10 part or Radix Rehmanniae 5-30 part as adjuvant drug.
Preferred consumption is: 25 parts of Gypsum Fibrosum, 10 parts of Rhizoma Chuanxiongs or by 15 parts of 10 parts of combination, Rhizoma Cimicifugaes, Radix Cyathulae or 15 parts of the Radix Achyranthis Bidentataes of 15 parts of 10 parts of Rhizoma Chuanxiongs and the Radixs Angelicae Dahuricae, 3 parts of Rhizoma Coptidis or Radix Rehmanniae.
The present invention also provides the method for preparing of this kind pharmaceutical composition active component, wherein:
When Rhizoma Chuanxiong and the Radix Angelicae Dahuricae are ministerial drug, when Rhizoma Cimicifugae, Radix Cyathulae or Radix Achyranthis Bidentatae, Rhizoma Coptidis or Radix Rehmanniae were adjuvant drug, this method for preparing comprised:
1) take by weighing each crude drug Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Cyathulae or Radix Achyranthis Bidentatae, Rhizoma Coptidis or Radix Rehmanniae, subsequent use.
2) Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Cyathulae or Radix Achyranthis Bidentatae, Rhizoma Coptidis or the Radix Rehmanniae of said proportioning added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 1.
3) Gypsum Fibrosum, the Rhizoma Cimicifugae with said proportioning adds 8～15 times of water gagings decoctions 1～3 time, and each 1～3 hour, filtration merged all filtratings, is concentrated into relative density 1.05～1.15 (70～85 ℃ of hot surveys), leaves standstill, and filters, and it is concentrated, dry to filtrate, and gets component 2.
4) merge component 1 and component 2, be ground into powder, mix homogeneously just has been prepared into the active component of medicine of the present invention.
Perhaps
When Rhizoma Chuanxiong is a ministerial drug, when Rhizoma Cimicifugae, Radix Cyathulae or Radix Achyranthis Bidentatae, Rhizoma Coptidis or Radix Rehmanniae were adjuvant drug, this method for preparing comprised:
1) take by weighing each crude drug Gypsum Fibrosum, Rhizoma Chuanxiong, Rhizoma Cimicifugae, Radix Cyathulae or Radix Achyranthis Bidentatae, Rhizoma Coptidis or Radix Rehmanniae, subsequent use.
2) Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Cyathulae or Radix Achyranthis Bidentatae, Rhizoma Coptidis or the Radix Rehmanniae of said proportioning added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 1.
3) Gypsum Fibrosum, the Rhizoma Cimicifugae with said proportioning adds 8～15 times of water gagings decoctions 1～3 time, and each 1～3 hour, filtration merged all filtratings, is concentrated into relative density 1.05～1.15 (70～85 ℃ of hot surveys), leaves standstill, and filters, and it is concentrated, dry to filtrate, and gets component 2.
4) merge component 1 and component 2, be ground into powder, mix homogeneously just has been prepared into the active component of medicine of the present invention.
The crude drug of pharmaceutical composition of the present invention can also be: as Gypsum Fibrosum 10-50 part of monarch drug; With constitute ministerial drug as Rhizoma Chuanxiong 5-15 part of ministerial drug or by Rhizoma Chuanxiong 5-15 part and Radix Angelicae Dahuricae 5-25 part; Herba Asari 3-10 part or Rhizoma Et Radix Notopterygii 5-15 part as adjuvant drug.
Preferred consumption is: 25 parts of Gypsum Fibrosum, 10 parts of Rhizoma Chuanxiongs or by 10 parts of 6 parts of combination, the Herba Asaris of 15 parts of 10 parts of Rhizoma Chuanxiongs and the Radixs Angelicae Dahuricae or Rhizoma Et Radix Notopterygiis.
The present invention also provides the method for preparing of this kind pharmaceutical composition active component, wherein:
When Rhizoma Chuanxiong and the Radix Angelicae Dahuricae are ministerial drug, when Herba Asari or Rhizoma Et Radix Notopterygii were adjuvant drug, this method for preparing comprised:
1) take by weighing each crude drug Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari or Rhizoma Et Radix Notopterygii, subsequent use.
2) Herba Asari of said weight proportion or Rhizoma Et Radix Notopterygii are added water and extract volatile oil in right amount, component 1; Medicinal liquid after distillation device is in addition collected, and the Gypsum Fibrosum of residue and said weight proportion adds 8～15 times of water gagings and decocts 1～3 time, each 1～3 hour, filters; Merge all filtratings, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill; Filter, filtrating is concentrated, dry, gets component 2.
3) Rhizoma Chuanxiong, the Radix Angelicae Dahuricae of said proportioning added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 3.
4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into the active component of medicine of the present invention.
Perhaps
When Rhizoma Chuanxiong was ministerial drug, Herba Asari or Rhizoma Et Radix Notopterygii were adjuvant drug, and this method for preparing comprises:
1) take by weighing each crude drug Gypsum Fibrosum, Rhizoma Chuanxiong, Herba Asari or Rhizoma Et Radix Notopterygii, subsequent use.
2) Herba Asari of said weight proportion or Rhizoma Et Radix Notopterygii are added water and extract volatile oil in right amount, component 1; Medicinal liquid after distillation device is in addition collected, and the Gypsum Fibrosum of residue and said weight proportion adds 8～15 times of water gagings and decocts 1～3 time, each 1～3 hour, filters; Merge all filtratings, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill; Filter, filtrating is concentrated, dry, gets component 2.
3) Rhizoma Chuanxiong of said proportioning is added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 3.
4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into the active component of medicine of the present invention.
The crude drug of pharmaceutical composition of the present invention can also be: as Gypsum Fibrosum 10-50 part of monarch drug; With constitute ministerial drug as Rhizoma Chuanxiong 5-15 part of ministerial drug or by Rhizoma Chuanxiong 5-15 part and Radix Angelicae Dahuricae 5-25 part; Herba Asari 3-10 part or Rhizoma Et Radix Notopterygii 5-15 part, Rhizoma Coptidis 1-10 part or Radix Rehmanniae 5-30 part as adjuvant drug.
Preferred consumption is: 25 parts of Gypsum Fibrosum, 10 parts of Rhizoma Chuanxiongs or by 15 parts of 6 parts of combination, the Herba Asaris of 15 parts of 10 parts of Rhizoma Chuanxiongs and the Radixs Angelicae Dahuricae or 10 parts of Rhizoma Et Radix Notopterygiis, 3 parts of Rhizoma Coptidis or Radix Rehmanniae.
The present invention also provides the method for preparing of this kind pharmaceutical composition active component, wherein:
When Rhizoma Chuanxiong and the Radix Angelicae Dahuricae are ministerial drug, when Herba Asari or Rhizoma Et Radix Notopterygii, Rhizoma Coptidis or Radix Rehmanniae were adjuvant drug, this method for preparing comprised:
1) take by weighing each crude drug Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari or Rhizoma Et Radix Notopterygii, Rhizoma Coptidis or Radix Rehmanniae, subsequent use.
2) Herba Asari of said weight proportion or Rhizoma Et Radix Notopterygii are added water and extract volatile oil in right amount, component 1; Medicinal liquid after distillation device is in addition collected, and the Gypsum Fibrosum of residue and said weight proportion adds 8～15 times of water gagings and decocts 1～3 time, each 1～3 hour, filters; Merge all filtratings, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill; Filter, filtrating is concentrated, dry, gets component 2.
3) Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Coptidis or the Radix Rehmanniae of said proportioning added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 3.
4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into the active component of medicine of the present invention.
Perhaps
When Rhizoma Chuanxiong is a ministerial drug, when Herba Asari or Rhizoma Et Radix Notopterygii, Rhizoma Coptidis or Radix Rehmanniae were adjuvant drug, this method for preparing comprised:
1) take by weighing each crude drug Gypsum Fibrosum, Rhizoma Chuanxiong, Herba Asari or Rhizoma Et Radix Notopterygii, Rhizoma Coptidis or Radix Rehmanniae, subsequent use.
2) Herba Asari of said weight proportion or Rhizoma Et Radix Notopterygii are added water and extract volatile oil in right amount, component 1; Medicinal liquid after distillation device is in addition collected, and the Gypsum Fibrosum of residue and said weight proportion adds 8～15 times of water gagings and decocts 1～3 time, each 1～3 hour, filters; Merge all filtratings, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leave standstill; Filter, filtrating is concentrated, dry, gets component 2.
3) Rhizoma Chuanxiong, Rhizoma Coptidis or the Radix Rehmanniae of said proportioning added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 3.
4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into the active component of medicine of the present invention.
The crude drug of pharmaceutical composition of the present invention can also be: as Gypsum Fibrosum 10-50 part of monarch drug; With constitute ministerial drug as Rhizoma Chuanxiong 5-15 part of ministerial drug or by Rhizoma Chuanxiong 5-15 part and Radix Angelicae Dahuricae 5-25 part; Rhizoma Cimicifugae 5-20 part, Radix Cyathulae or Radix Achyranthis Bidentatae 5-25 part, Herba Asari 3-10 part or Rhizoma Et Radix Notopterygii 5-15 part as adjuvant drug.
Preferred consumption is: 25 parts of Gypsum Fibrosum, 10 parts of Rhizoma Chuanxiongs or by 10 parts of 10 parts of combination, Rhizoma Cimicifugaes, Radix Cyathulae or 15 parts of the Radix Achyranthis Bidentataes of 15 parts of 10 parts of Rhizoma Chuanxiongs and the Radixs Angelicae Dahuricae, 6 parts of Herba Asaris or Rhizoma Et Radix Notopterygiis
The present invention also provides the method for preparing of this kind pharmaceutical composition active component, wherein:
When Rhizoma Chuanxiong and the Radix Angelicae Dahuricae are ministerial drug, when Rhizoma Cimicifugae, Radix Cyathulae or Radix Achyranthis Bidentatae, Herba Asari or Rhizoma Et Radix Notopterygii were adjuvant drug, this method for preparing comprised:
1) take by weighing each crude drug Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Cyathulae or Radix Achyranthis Bidentatae, Herba Asari or Rhizoma Et Radix Notopterygii, subsequent use.
2) Herba Asari of said weight proportion or Rhizoma Et Radix Notopterygii are added water and extract volatile oil in right amount, component 1; Medicinal liquid after distillation device is in addition collected, and the Gypsum Fibrosum of residue and said weight proportion, Rhizoma Cimicifugae add 8～15 times of water gagings and decoct each 1～3 hour 1～3 time; Filter, merge all filtratings, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed); Leave standstill; Filter, filtrating is concentrated, dry, gets component 2.
3) Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Cyathulae or the Radix Achyranthis Bidentatae of said proportioning added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 3.
4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into the active component of medicine of the present invention.
Perhaps
When Rhizoma Chuanxiong is a ministerial drug, when Rhizoma Cimicifugae, Radix Cyathulae or Radix Achyranthis Bidentatae, Herba Asari or Rhizoma Et Radix Notopterygii were adjuvant drug, this method for preparing comprised:
1) take by weighing each crude drug Gypsum Fibrosum, Rhizoma Chuanxiong, Rhizoma Cimicifugae, Radix Cyathulae or Radix Achyranthis Bidentatae, Herba Asari or Rhizoma Et Radix Notopterygii, subsequent use.
2) Herba Asari of said weight proportion or Rhizoma Et Radix Notopterygii are added water and extract volatile oil in right amount, component 1; Medicinal liquid after distillation device is in addition collected, and the Gypsum Fibrosum of residue and said weight proportion, Rhizoma Cimicifugae add 8～15 times of water gagings and decoct each 1～3 hour 1～3 time; Filter, merge all filtratings, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed); Leave standstill; Filter, filtrating is concentrated, dry, gets component 2.
3) Rhizoma Chuanxiong, Radix Cyathulae or the Radix Achyranthis Bidentatae of said proportioning added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 3.
4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into the active component of medicine of the present invention.
The crude drug of pharmaceutical composition of the present invention can also be: as Gypsum Fibrosum 10-50 part of monarch drug; With constitute ministerial drug as Rhizoma Chuanxiong 5-15 part of ministerial drug or by Rhizoma Chuanxiong 5-15 part and Radix Angelicae Dahuricae 5-25 part; Rhizoma Cimicifugae 5-20 part, Radix Cyathulae or Radix Achyranthis Bidentatae 5-25 part, Herba Asari 3-10 part or Rhizoma Et Radix Notopterygii 5-15 part, Rhizoma Coptidis 1-10 part or Radix Rehmanniae 5-30 part as adjuvant drug
Preferred consumption is: 25 parts of Gypsum Fibrosum, 10 parts of Rhizoma Chuanxiongs or by 15 parts of 10 parts of combination, Rhizoma Cimicifugaes, Radix Cyathulae or 15 parts of Radix Achyranthis Bidentataes, 6 parts of Herba Asaris or 10 parts of the Rhizoma Et Radix Notopterygiis of 15 parts of 10 parts of Rhizoma Chuanxiongs and the Radixs Angelicae Dahuricae, 3 parts of Rhizoma Coptidis or Radix Rehmanniae.
The present invention also provides the method for preparing of this kind pharmaceutical composition active component, wherein:
When Rhizoma Chuanxiong and the Radix Angelicae Dahuricae are ministerial drug, when Rhizoma Cimicifugae, Radix Cyathulae or Radix Achyranthis Bidentatae, Herba Asari or Rhizoma Et Radix Notopterygii, Rhizoma Coptidis or Radix Rehmanniae were adjuvant drug, this method for preparing comprised:
1) take by weighing each crude drug Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Cyathulae or Radix Achyranthis Bidentatae, Herba Asari or Rhizoma Et Radix Notopterygii, Rhizoma Coptidis or Radix Rehmanniae, subsequent use.
2) Herba Asari of said weight proportion or Rhizoma Et Radix Notopterygii are added water and extract volatile oil in right amount, component 1; Medicinal liquid after distillation device is in addition collected, and the Gypsum Fibrosum of residue and said weight proportion, Rhizoma Cimicifugae add 8～15 times of water gagings and decoct each 1～3 hour 1～3 time; Filter, merge all filtratings, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed); Leave standstill; Filter, filtrating is concentrated, dry, gets component 2.
3) Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Cyathulae or Radix Achyranthis Bidentatae, Rhizoma Coptidis or the Radix Rehmanniae of said proportioning added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 3.
4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into the active component of medicine of the present invention.
Perhaps
When Rhizoma Chuanxiong is a ministerial drug, when Rhizoma Cimicifugae, Radix Cyathulae or Radix Achyranthis Bidentatae, Herba Asari or Rhizoma Et Radix Notopterygii, Rhizoma Coptidis or Radix Rehmanniae were adjuvant drug, this method for preparing comprised:
1) take by weighing each crude drug Gypsum Fibrosum, Rhizoma Chuanxiong, Rhizoma Cimicifugae, Radix Cyathulae or Radix Achyranthis Bidentatae, Herba Asari or Rhizoma Et Radix Notopterygii, Rhizoma Coptidis or Radix Rehmanniae, subsequent use.
2) Herba Asari of said weight proportion or Rhizoma Et Radix Notopterygii are added water and extract volatile oil in right amount, component 1; Medicinal liquid after distillation device is in addition collected, and the Gypsum Fibrosum of residue and said weight proportion, Rhizoma Cimicifugae add 8～15 times of water gagings and decoct each 1～3 hour 1～3 time; Filter, merge all filtratings, be concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed); Leave standstill; Filter, filtrating is concentrated, dry, gets component 2.
3) Rhizoma Chuanxiong, Radix Cyathulae or Radix Achyranthis Bidentatae, Rhizoma Coptidis or the Radix Rehmanniae of said proportioning added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 3.
4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing just has been prepared into the active component of medicine of the present invention.
At last, the invention provides above-mentioned various pharmaceutical composition and have the purposes in the medicine of analgesic, antiinflammatory and analgesic activity in preparation.
Medical material used in the present invention is:
Rhizoma Chuanxiong according to the invention is the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..
The Radix Angelicae Dahuricae according to the invention is samphire Radix Angelicae Dahuricae Angelica dahurica (Fisch.ex Hoffm.) Benth.Et Hook.f
. or the dry root of Radix angelicae dahuricae Angelica dahurica (Fisch.ex Hoffm.) Benth.Et Hook.f.var.formosana (Boiss.) Shan etYuan.
Gypsum Fibrosum according to the invention is a Sulfates mineral anhydrite family Gypsum Fibrosum, the main hydrous calcium sulfate (CaSO that contains 42H 2O).
Rhizoma Cimicifugae according to the invention is the dry rhizome of the big SANYE Rhizoma Cimicifugae of ranunculaceae plant Cimicifuga heracleifolia Kom., Rhizoma Cimicifugae Cimicifuga dahurica (Turcz.) Maxim of Xingan or Rhizoma Cimicifugae Cimicifuga foetida L..
Radix Achyranthis Bidentatae according to the invention is dry root and the processed product thereof of amaranthaceous plant Radix Achyranthis Bidentatae Achyranthes bidentata Blume, comprises Radix Achyranthis Bidentatae, Radix Achyranthis Bidentatae (processed with wine).
Radix Cyathulae according to the invention is dry root and the processed product thereof of amaranthaceous plant Radix Cyathulae Cyathula officinalis Kuan, comprises Radix Cyathulae, wine Radix Cyathulae.
Rhizoma Coptidis of the present invention is the dry rhizome of ranunculaceae plant Rhizoma Coptidis Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall Coptis teeta Wall., comprises flavor company, refined company, Coptis Teeta Wall.
Radix Rehmanniae according to the invention is the tuber of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch., comprises Radix Rehmanniae, Radix Rehmanniae.
Herba Asari according to the invention is the root and rhizome of aristolochiaceae plant Herba Asari Asarum heterotropoides Fr.Schmidt var.mandshuricum (Maxim.) Kitag., Seoul Herba Asari Asarum sieboldii Miq.var.seoulense Nakai or magnificent Herba Asari Asarum sieboldii Miq..
Rhizoma Et Radix Notopterygii according to the invention is dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii Notopterygium incisum Ting ex H.T.Chang or Radix et Rhizoma Notopterygii Notopterygium forbesii Boiss..
The consumption of each crude drug according to the invention all refers to weight portion.
Pharmaceutical composition of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations.For example can these raw medicinal material pulverize mix homogeneously be processed powder takes after mixing it with water; Can also can utilize modern technologies to extract these raw medicinal materials, as passing through supercritical carbon dioxide (SFE-CO these raw medicinal materials decocting together or ethanol extraction 2) extraction or ultrasonic extraction etc., concentrate drying then.But bring into play drug effect better for each crude drug that makes this medicine, preferably the Rhizoma Chuanxiong in all medical materials, Rhizoma Coptidis, Radix Rehmanniae, the Radix Angelicae Dahuricae, Radix Cyathulae, Radix Achyranthis Bidentatae are carried out ethanol extraction, the Gypsum Fibrosum in all medical materials, Rhizoma Cimicifugae, Herba Asari, Rhizoma Et Radix Notopterygii are carried out decocting.
Needed various conventional adjuvants when active ingredient in pharmaceutical of the present invention can add the preparation different dosage form; Be prepared into any dosage form for oral administration commonly used like a conventional method of Chinese medicinal such as disintegrating agent, lubricant, binding agent, like granule, electuary, tablet, drop pill, pill, capsule, soft capsule, oral liquid, mixture etc.
That pharmaceutical composition of the present invention has is analgesic, antiinflammatory and analgesic activity, is specially adapted to treat heating and head-body-pain, oral ulcer or diseases such as periodontitis, various headaches due to the flu.On the other hand, with regard to theory of Chinese medical science, if because the drug main of the present invention heat of letting out Yang Ming or taste clearly, so be suitable for bright hot and suffocating, the treatment that taste lie prostrate diseases such as fire, headache of the bright qifen fever of the said sun of the traditional Chinese medical science, sun in the nature of things.
[novelty of invention]
Thinking of the present invention is derived from the tcm clinical practice pathogenesis analysis to various flu, oral ulcer and periodontitis.
With regard to flu, positive bright syndrome in QI system is the easiest key link that causes heating and head-body-pain (finger or whole-body muscle, arthralgia).So pharmaceutical composition of the present invention is reused hot sweet cold and cool Gypsum Fibrosum and is monarch, the heat of straight clearing heat in QI system branch; Use Rhizoma Chuanxiong or uses Rhizoma Chuanxiong and the Radix Angelicae Dahuricae is minister, the heresy of diffusing six climate exopathogens; Use Rhizoma Cimicifugae, Radix Cyathulae or Radix Achyranthis Bidentatae, Herba Asari, Rhizoma Et Radix Notopterygii etc. for assistant, help diffusing exopathogen; Rhizoma Coptidis, Radix Rehmanniae can clearing away heat from YING and blood systems, again can expelling the heat of YING system to QI system, nourish cloudy Tianjin, anti-deeply evil.Therefore, this invention pharmaceutical composition can be brought down a fever rapidly, can effectively alleviate the syndrome of WEI system such as head-body-pain due to the six climate exopathogens pathogenic factor again.
With regard to oral ulcer (belonging to the traditional Chinese medical science " erosion of the oral mucosa " category) and periodontitis (belonging to the traditional Chinese medical science " gingival atrophy " category), therefore, present decoction or the Chinese patent medicine effective percentage that appears on the market are all not high, only have the minority kind that the lighter patient of the state of an illness is had certain curative effect.Pharmaceutical composition of the present invention is reused hot sweet cold and cool Gypsum Fibrosum and is monarch, straight clear in the heat of burnt taste; Dispel the wind, invigorate blood circulation with having, the Rhizoma Chuanxiong of pain-relieving functions or with the minister that is combined as of the Rhizoma Chuanxiong and the Radix Angelicae Dahuricae; The heresy of diffusing taste, blood system; Constitute the square basically of pharmaceutical composition of the present invention; Wherein can singly use Rhizoma Chuanxiong, also can the Rhizoma Chuanxiong and the Radix Angelicae Dahuricae be used to heighten the effect of a treatment together, these two kinds of prescriptions all are to obtain based on identical Chinese medicine prescription thinking.It is single with the better effect of each flavor crude drug that the inventor is surprised to find that in clinical practice this combination can obtain; And produced new synergism; Be able to confirm the core of having accomplished pharmaceutical composition of the present invention thus through a series of zooperies subsequently.
Subsequently, the inventor combines the central idea of Chinese medicine " medicine becomes with card ", and to different patients body constitution or different complication, assistant helps the volt fire that looses with Rhizoma Cimicifugae, Radix Cyathulae or Radix Achyranthis Bidentatae, Herba Asari, Rhizoma Et Radix Notopterygii etc.; Rhizoma Coptidis, Radix Rehmanniae can clearing away heat and cooling blood, have and can YIN nourishing support liquid.Therefore, be the basis with basic side, the scope of application that is equipped with behind the various adjuvants is more extensive; Through clinical verification repeatedly, the inventor confirms that this pharmaceutical composition all has better curative effect to above-mentioned patient's scorching hot, swollen, pain.
Through a series of experiments; The medicine that proof makes with above-mentioned crude drug has analgesic, the antiinflammatory and the analgesic activity of uniqueness; Therefore; Can be widely used in the treatment of multiple heating, inflammation, painful diseases, the heating due to being specially adapted to catch a cold or head-body-pain, oral ulcer and diseases such as periodontitis, various headaches.Because the combination of the crude drug of pharmaceutical composition of the present invention obviously embodies the effect of diseases such as bright hot and suffocating, the taste volt fire of the bright qifen fever of the said removing summer-heat sun of the traditional Chinese medical science, sun, headache; Therefore, above-mentioned traditional Chinese medical science disease belongs to the therapeutic domain of pharmaceutical composition of the present invention in the nature of things.And drug regimen of the present invention does not all have open in the prior art, belongs to a kind of medicine of brand-new combination.
Those skilled in the art should be appreciated that to obtaining certain function, can only use a kind of or use the similar raw medicinal material of traditional Chinese medical science effect more than 2 kinds simultaneously, but the dosage of medicine also should change thereupon.In the present invention; The Rhizoma Chuanxiong of 5-15 weight portion can be brought into play the effect of the 5-25 weight portion Radix Angelicae Dahuricae; The Herba Asari of 3-10 weight portion can be brought into play the effect of 5-15 weight portion Rhizoma Et Radix Notopterygii; The Rhizoma Coptidis of 1-10 weight portion can be brought into play the effect of 5-30 weight portion Radix Rehmanniae, if but use the similar raw medicinal material of above-mentioned traditional Chinese medical science effect simultaneously, their consumption also can correspondingly reduce.
The raw medicinal material effective ingredient that Different Extraction Method extracted, the kind of toxic component and content maybe be different, so if same drug regimen is selected different extraction processes, the dosage ratio of its raw medicinal material also should give corresponding adjustment.For example; Raw medicinal material Rhizoma Chuanxiong water in the drug regimen of the present invention is carried and can be used the 10-15 weight portion; Alcohol extraction, supercritical extraction or supersound extraction can only need the 3-6 weight portion; Radix Angelicae Dahuricae water is carried and can be used the 5-25 weight portion, and alcohol extraction, supercritical extraction or supersound extraction can only need the 2-8 weight portion, but can maintain metastable level with the consumption of other raw medicinal materials of its compatibility.
Because of above-mentioned reason, this invention raw medicinal material is not or/and the selection of its dosage influences realization of the present invention.
[specific embodiment]
Pharmacological evaluation:
Below come further to set forth the beneficial effect of pharmaceutical composition according to the invention through Test Example.
1 material
1.1 animal
KM kind mice, SPF level, body weight 18～22g, ♀ ♂ dual-purpose (hot plate method is selected female mice for use, and ear swelling is selected male mice for use); The SD rat, SPF level, body weight 180～220g, ♀ ♂ dual-purpose.New zealand white rabbit, body weight are 2～3kg.1.2 instrument
GJ-8420 type hot-plate instrument (the white stone electronics medicine in Ninghai instrument plant); Electronic balance (Sartorius,, BP121S); It is thus clear that/ultraviolet spectrophotometer (UV2450, Japanese SHIMADZU).
1.3 medicine and reagent
Pharmaceutical composition N1-N49 of the present invention (the crude drug kind of each pharmaceutical composition is seen note, and the consumption of each crude drug is referring to the preferable amount of each crude drug that provides in the summary of the invention), gastric infusion is made into desired concn with distilled water during use; Aspirin enteric coatel tablets (Shaanxi white deer pharmacy joint-stock company, commercially available); Ivens blue (Uni-CHEM, lot: commercially available); Dry yeast (Hubei Angel Yeast Co.,Ltd, commercially available, face with preceding adding distil water and grind, be made into 20% suspension confession experiment usefulness); Vaccinum Pertussis et Toxoidum Diphthero Tetanicum Adsorbatum, diphtheria, cholera and Typhoid-Paratyphoid A and B Vaccine and Tetanus Toxoid Complex, Lanzhou Inst. of Biological Products, Ministry of Public Health's product; Glacial acetic acid, xylene are homemade analytical pure.
2 methods and result
2.1 statistical method
Adopt the SPSS10.0 statistical software to carry out statistical procedures.The statistical method measurement data is used One-way-ANOVA, compares in twos between many groups, and with LSD (Least-Signficant-Difference) statistics, enumeration data is added up with Pearson Chi-square.
2.2 refrigeration function
2.2.1 the whooping cough vaccine is caused the influence of new zealand rabbit heating body temperature
432 of new zealand white rabbits, ♀ ♂ dual-purpose is surveyed normal anus temperature 2 times, and temperature fluctuation is less than 0.5 degree person auricular vein injection pertussis diphtheria tetanus mixed vaccine 2ml/kg.Fervescence is selected for use greater than 0.5 degree person behind the 1h.Selected rabbit is divided into blank group, positive drug aspirin group, Gypsum Fibrosum group, Rhizoma Chuanxiong group, Radix Angelicae Dahuricae group and medicine N1-N49 of the present invention at random organizes (totally 54 groups; Every group 8); Irritate stomach respectively and give corresponding water or medicine, the dosage of medicine of the present invention is 4.5g crude drug/Kg body weight (for clinical equivalent dosage), each rabbit respectively at administration after 1h; 2h; 3h surveys the anus temperature, body temperature changing value (difference of " body temperature-basal body temperature that 1h, 2h, 3h record behind the medicine ") behind the comparison medicine, and carry out statistical procedures.The result sees table 1:
Table 1 pharmaceutical composition causes the influence (
Figure BSA00000667662900091
n=8) of new zealand rabbit heating body temperature to the whooping cough vaccine
Figure BSA00000667662900092
Figure BSA00000667662900101
Annotate: compare * P＜0.05, * * P＜0.01 with the blank group
▲: curative effect is superior to N1-N3;
△: curative effect is superior to N4-N15;
★: curative effect is superior to N16-N39.
2.2.2 dry yeast is caused the influence of rat fever
Rat adapts to 3 days in laboratory (room temperature is 22 ± 1 degree), and every day, adaptability was measured anus temperature 2 times, and continuous 2 days, the rat of selecting for use basal body temperature 37～37.7 to spend, back skin injection 20% sterilised yeast suspension (10mg/kg).Choose the above person of fervescence 1 degree behind the modeling 3.5h; Be divided into 54 groups at random; Every group 10; Be respectively blank group, positive drug aspirin group, Gypsum Fibrosum group, Rhizoma Chuanxiong group, Radix Angelicae Dahuricae group and medicine N1 to N49 of the present invention and organize, irritate stomach respectively and give corresponding water or medicine, the dosage of medicine of the present invention is 6.0g crude drug/Kg body weight (for clinical equivalent dosage).Each is organized 1.5h after the administration, 2h, 3h and is not measured body temperature, calculates also relatively body temperature changing value (difference of " body temperature-basal body temperature that records behind the medicine "), result such as table 2:
Table 2 pharmaceutical composition is to the influence (
Figure BSA00000667662900112
n=10) of rat fever due to the yeast
Figure BSA00000667662900113
Figure BSA00000667662900121
Annotate: compare * P＜0.05, * * P＜0.01 with the blank group
▲: curative effect is superior to N1-N3;
△: curative effect is superior to N4-N15;
★: curative effect is superior to N16-N39.
2.3 analgesic activity
2.3.1 hot plate method
Get female mice; Before formal experiment, screen with hot plate dolorimeter (temperature is 55 ± 0.5 degree), record is selected 5～30S stable reaction from putting into dolorimeter to occurring licking metapedes required time (S); The mice that do not jump supplies experiment usefulness, with this as administration before pain threshold.Above-mentioned screening is obtained 540 of mices; Be divided into 54 groups at random; Every group 10; Be respectively blank group, positive drug aspirin group, Gypsum Fibrosum group, Rhizoma Chuanxiong group, Radix Angelicae Dahuricae group and medicine N1 to N49 of the present invention and organize, irritate stomach respectively and give corresponding water or medicine, the dosage of medicine of the present invention is 7.5g crude drug/Kg body weight (for clinical equivalent dosage).Each is organized and is administered once every day, and administration time is 4d.0.5h, 1h, 1.5h respectively organize mice and measure pain threshold with method same as described above respectively after the last administration, and record also compares the analgesic activity between each medicine.The result sees table 3:
Table 3 pharmaceutical composition is licked the influence (
Figure BSA00000667662900131
n=10) of foot reaction to hot plate method
Figure BSA00000667662900132
Annotate: with blank control group contrast, * P＜0.05, * * P＜0.01
▲: curative effect is superior to N1-N3;
△: curative effect is superior to N4-N15;
★: curative effect is superior to N16-N39.
2.3.2 writhing method
Get 648 of mices, ♀ ♂ half and half is divided into 54 groups at random; Every group 12, be respectively blank group, positive aspirin group, Gypsum Fibrosum group, Rhizoma Chuanxiong group, Radix Angelicae Dahuricae group and medicine N1 to N49 of the present invention and organize, irritate stomach respectively and give corresponding water or medicine; The dosage of medicine of the present invention is 7.5g crude drug/Kg body weight (for clinical equivalent dosage); Gastric infusion 4 days, once a day, 1h after the last administration; Each organizes the equal lumbar injection 1% acetic acid 10ml/kg of mice, record and inject relatively that mice occurs in the 15min behind the acetic acid turn round the body number of times.The result sees table 4:
Table 4 pharmaceutical composition Dichlorodiphenyl Acetate causes the influence (
Figure BSA00000667662900142
n=12) of mouse writhing reaction
Annotate: with blank control group contrast, * P＜0.05, * * P＜0.01
▲: curative effect is superior to N1-N3;
△: curative effect is superior to N4-N15;
★: curative effect is superior to N16-N39.
2.4 antiinflammatory action
2.4.1 xylol causes the influence of mice auricle swelling
Get 540 of male mices, be divided into 54 groups (10 every group) at random, be respectively blank group, positive drug aspirin group, Gypsum Fibrosum group, Rhizoma Chuanxiong group, Radix Angelicae Dahuricae group and medicine N1 to N49 of the present invention and organize; Irritate stomach respectively and give corresponding water or medicine, the dosage of medicine of the present invention is 7.5g crude drug/Kg body weight (for clinical equivalent dosage), gastric infusion 4 days; Once a day; 1h after the last administration, each is organized the mouse right ear two sides and evenly smears xylene (40ml/ only), with left ear as contrast.Take off cervical vertebra behind the 1h and put to death mice, cut two ears along the auricle baseline, lay circular auricle at two ear antimeres respectively with the 9mm card punch, electronic analytical balance is weighed, and calculating is also compared swelling degree (the difference meansigma methods with every Mus left and right sides auricle weight is represented).The result sees table 5:
Table 5 pharmaceutical composition xylol causes the influence
Figure BSA00000667662900161
of mice auricle swelling
Figure BSA00000667662900162
Figure BSA00000667662900171
Annotate: with blank control group contrast, * P＜0.05, * * P＜0.01
▲: curative effect is superior to N1-N3;
△: curative effect is superior to N4-N15;
★: curative effect is superior to N16-N39.
2.4.2 influence to the mouse peritoneal capillary permeability
Get 540 of mices, ♀ ♂ half and half is divided into 54 groups (10 every group) at random; Being respectively blank group, positive drug aspirin group, Gypsum Fibrosum group, Rhizoma Chuanxiong group, Radix Angelicae Dahuricae group and medicine N1 to N49 of the present invention organizes; Irritate stomach respectively and give corresponding water or medicine, the dosage of medicine of the present invention is 7.5g crude drug/Kg body weight (for clinical equivalent dosage), gastric infusion 4 days; Once a day, 1h tail vein injection 0 after the last administration.5% azovan blue normal saline solution 20ml/kg,, while lumbar injection 1% glacial acetic acid 10ml/kg; Take off cervical vertebra behind the 20min and put to death animal; Use the normal saline flushing abdominal cavity, suction pipe is collected peritoneal fluid, and the centrifuging and taking supernatant is measured absorbance (A) in the 590nm place; And carry out statistical comparisons, the result sees table 6:
The influence
Figure BSA00000667662900172
of table 6 pharmaceutical composition Dichlorodiphenyl Acetate induced mice abdominal cavity capillary permeability
Figure BSA00000667662900173
Figure BSA00000667662900181
Annotate: with blank control group contrast, * P＜0.05, * * P＜0.01
▲: curative effect is superior to N1-N3;
3, discuss
This experimental result shows; Pharmaceutical composition N1-N49 of the present invention causes rat and whooping cough vaccine to yeast and causes fever in rabbits significant refrigeration function is arranged; Obviously improve the pain threshold of mice hot plate method; Suppress the mouse writhing reaction due to the acetic acid, and suppress significantly that capillary permeability increases the mice auricle swelling that causes with xylene due to the acetic acid; And with regard to general curative effect, the effect of N4-N15 is superior to N1-N3, and the effect of N16-N39 is superior to N4-N15, and the effect of N40-N49 is superior to N16-N39.Three kinds of combinations that experimental result has also proved N1-N3 have produced extra synergism than the simple combination of single medical material; And; The synergism that is obtained between the N1-N3 is basic identical; Proved to be based between the N1-N3 that identical prescription thinking obtains, and the simple combination of these medical materials that are superior to.Wherein the combination of three flavor medical materials is superior to the combination of two flavor medical materials.In addition, on the basis of this combination, ministerial drug, adjuvant drug that has increased other etc. all can make drug effect further brought into play.Therefore visible, N1-N49 has more analgesic, and analgesia and antiinflammatory action can be used to comprise the treatment of the relevant disease of cold, fever, head-body-pain, oral ulcer, periodontitis, various headaches.
Note: the crude drug combination of pharmaceutical composition N1-N49 of the present invention sees the following form:
The pharmaceutical composition numbering The crude drug combination
N1 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae
N2 Gypsum Fibrosum, Rhizoma Chuanxiong
N3 Gypsum Fibrosum, the Radix Angelicae Dahuricae
N4 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Cyathulae
N5 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Achyranthis Bidentatae
N6 Gypsum Fibrosum, Rhizoma Chuanxiong, Rhizoma Cimicifugae, Radix Cyathulae
N7 Gypsum Fibrosum, Rhizoma Chuanxiong, Rhizoma Cimicifugae, Radix Achyranthis Bidentatae
N8 Gypsum Fibrosum, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Cyathulae
N9 Gypsum Fibrosum, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Achyranthis Bidentatae
N10 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari
N11 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Et Radix Notopterygii
N12 Gypsum Fibrosum, Rhizoma Chuanxiong, Herba Asari
N13 Gypsum Fibrosum, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii
N14 Gypsum Fibrosum, the Radix Angelicae Dahuricae, Herba Asari
N15 Gypsum Fibrosum, the Radix Angelicae Dahuricae, Rhizoma Et Radix Notopterygii
N16 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Cyathulae, Rhizoma Coptidis
N17 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Achyranthis Bidentatae, Rhizoma Coptidis
N18 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Cyathulae, Radix Rehmanniae
N19 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Achyranthis Bidentatae, Radix Rehmanniae
N20 Gypsum Fibrosum, Rhizoma Chuanxiong, Rhizoma Cimicifugae, Radix Cyathulae, Rhizoma Coptidis
N21 Gypsum Fibrosum, Rhizoma Chuanxiong, Rhizoma Cimicifugae, Radix Achyranthis Bidentatae, Rhizoma Coptidis
N22 Gypsum Fibrosum, Rhizoma Chuanxiong, Rhizoma Cimicifugae, Radix Cyathulae, Radix Rehmanniae
N23 Gypsum Fibrosum, Rhizoma Chuanxiong, Rhizoma Cimicifugae, Radix Achyranthis Bidentatae, Radix Rehmanniae
N24 Gypsum Fibrosum, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Cyathulae, Rhizoma Coptidis
N25 Gypsum Fibrosum, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Achyranthis Bidentatae, Rhizoma Coptidis
N26 Gypsum Fibrosum, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Cyathulae, Radix Rehmanniae
N27 Gypsum Fibrosum, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Achyranthis Bidentatae, Radix Rehmanniae
N28 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari, Rhizoma Coptidis
N29 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Et Radix Notopterygii, Rhizoma Coptidis
N30 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari, Radix Rehmanniae
N31 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Et Radix Notopterygii, Radix Rehmanniae
N32 Gypsum Fibrosum, Rhizoma Chuanxiong, Herba Asari, Rhizoma Coptidis
N33 Gypsum Fibrosum, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Rhizoma Coptidis
N34 Gypsum Fibrosum, Rhizoma Chuanxiong, Herba Asari, Radix Rehmanniae
N35 Gypsum Fibrosum, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Radix Rehmanniae
N36 Gypsum Fibrosum, the Radix Angelicae Dahuricae, Herba Asari, Rhizoma Coptidis
N37 Gypsum Fibrosum, the Radix Angelicae Dahuricae, Rhizoma Et Radix Notopterygii, Rhizoma Coptidis
N38 Gypsum Fibrosum, the Radix Angelicae Dahuricae, Herba Asari, Radix Rehmanniae
N39 Gypsum Fibrosum, the Radix Angelicae Dahuricae, Rhizoma Et Radix Notopterygii, Radix Rehmanniae
N40 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Cyathulae, Herba Asari
N41 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Cyathulae, Rhizoma Et Radix Notopterygii
N42 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Cyathulae, Herba Asari, Rhizoma Coptidis
N43 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Cyathulae, Herba Asari, Radix Rehmanniae
N44 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Achyranthis Bidentatae, Herba Asari
?N45 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Achyranthis Bidentatae, Rhizoma Et Radix Notopterygii
?N46 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Achyranthis Bidentatae, Herba Asari, Rhizoma Coptidis
?N47 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Achyranthis Bidentatae, Herba Asari, Radix Rehmanniae
?N48 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Achyranthis Bidentatae, Rhizoma Et Radix Notopterygii, Rhizoma Coptidis
?N49 Gypsum Fibrosum, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Radix Achyranthis Bidentatae, Rhizoma Et Radix Notopterygii, Radix Rehmanniae
Method for preparing:
Below enumerated the multiple method for preparing pharmaceutical composition of the present invention, but these methods only are illustrative, but not are intended to scope of the present invention is made restriction.
The granule preparation of [embodiment 1] pharmaceutical composition of the present invention
Take by weighing Gypsum Fibrosum 20g, Rhizoma Chuanxiong 10g and/or Radix Angelicae Dahuricae 15g, subsequent use.
Rhizoma Chuanxiong and/or the Radix Angelicae Dahuricae are added the ethanol extraction 3 times of 8 times of amounts 70%, each 1 hour, filter merging filtrate; Decompression recycling ethanol is concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), leaves standstill, and filters; Filtrating concentrating under reduced pressure below 60 ℃ becomes thick paste, and drying gets component 1.
Gypsum Fibrosum is added 10 times of water gagings decoct 3 times, each 1 hour, filtration merged all filtratings, was concentrated into relative density 1.05～1.15 (70～85 ℃ of hot surveys), left standstill, and filtered, and filtrating is concentrated, dry, gets component 2.
Merge component 1 and component 2, add an amount of Icing Sugar, mix homogeneously, extrusion granulator, dry below 60 ℃, granulate, packing promptly gets; Or, being ground into dried cream powder with thick paste drying under reduced pressure to dried cream, dry granulation promptly gets.
The preparation tablets of [embodiment 2] pharmaceutical composition of the present invention
Take by weighing Gypsum Fibrosum 20g, Rhizoma Chuanxiong 10g, Radix Angelicae Dahuricae 15g, Rhizoma Cimicifugae 10g, Radix Cyathulae 15g, subsequent use.
Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Cyathulae or Radix Achyranthis Bidentatae are added 8 times of amount ethanol extractions of 60% 3 times, each 1 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 1.
Gypsum Fibrosum, Rhizoma Cimicifugae are added 10 times of water gagings decoct 3 times, each 1 hour, filtration merged all filtratings, was concentrated into relative density 1.05～1.15 (70～85 ℃ of hot surveys), left standstill, and filtered, and filtrating is concentrated, dry, gets component 2.
Merge component 1 and component 2, pulverize, mix homogeneously, tabletting promptly gets.
The capsule preparation of [embodiment 3] pharmaceutical composition of the present invention
Take by weighing Gypsum Fibrosum 20g, Rhizoma Chuanxiong 10g, Radix Angelicae Dahuricae 15g, Rhizoma Cimicifugae 10g, Radix Cyathulae 15g, Radix Rehmanniae 15g, subsequent use.
Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Cyathulae, Radix Rehmanniae are added 8 times of amount ethanol extractions of 70% 3 times, each 1 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 1.
Gypsum Fibrosum, Rhizoma Cimicifugae are added 10 times of water gagings decoct 3 times, each 1 hour, filtration, merging filtrate is concentrated into relative density 1.05～1.15 (70～85 ℃ of hot surveys), leaves standstill, and filters, and filtrating is concentrated, dry, gets component 2.
Merge component 1 and component 2, be ground into powder, mix homogeneously is crossed sieve No. six, and filled hard capsules promptly gets.
The oral liquid preparation of [embodiment 4] pharmaceutical composition of the present invention
Take by weighing Gypsum Fibrosum 20g, Rhizoma Chuanxiong 10g, Radix Angelicae Dahuricae 15g, Herba Asari 6g, Rhizoma Coptidis 3g, subsequent use.
Herba Asari is added 10 times of water gagings, and steam distillation is collected distillate, gets component 1; Medicinal liquid after distillation device is in addition collected, and residue and Gypsum Fibrosum add 10 times of water gagings and decoct 3 times, each 1 hour, filters; Merging filtrate is concentrated into relative density 1.05～1.15 (70～85 ℃ of heat are surveyed), adds 70% ethanol precipitate with ethanol; Get the supernatant decompression recycling ethanol, it is an amount of to add water, stirs; Leave standstill, filter, get component 2.
Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Coptidis are added 8 times of amount ethanol extractions of 70% 3 times, each 1 hour, filter, merging filtrate, decompression recycling ethanol, it is an amount of to add water, stirs, and leaves standstill, filter, component 3.
Merge component 2 and component 3, add component 1, stir, promptly get.
The granule preparation of [embodiment 5] pharmaceutical composition of the present invention
Take by weighing Gypsum Fibrosum 20g, Rhizoma Chuanxiong 10g, Radix Angelicae Dahuricae 15g, Rhizoma Cimicifugae 10g, Radix Cyathulae 15g, Herba Asari 6g, subsequent use.
Herba Asari is added 10 times of water gagings, and steam distillation is collected volatile oil, gets component 1; Medicinal liquid after distillation device is in addition collected, and residue and Gypsum Fibrosum, Rhizoma Cimicifugae add 10 times of water gagings and decoct 3 times, and each 1 hour, filtration, merging filtrate is concentrated into relative density 1.05～1.15 (70～85 ℃ of hot surveys), leaves standstill, and filters, and filtrating is concentrated, dry, gets component 2.
Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Cyathulae are added 8 times of amount ethanol extractions of 60% 3 times, each 1 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 3.
Merge component 2 and component 3, dry granulation, spray adds component 1, and mixing promptly gets.
The granule preparation of [embodiment 6] pharmaceutical composition of the present invention
Take by weighing Gypsum Fibrosum 20g, Rhizoma Chuanxiong 10g, Radix Angelicae Dahuricae 15g, Rhizoma Cimicifugae 10g, Radix Cyathulae 15g, Rhizoma Et Radix Notopterygii 10g, Rhizoma Coptidis 3g, subsequent use.
Rhizoma Et Radix Notopterygii is added 10 times of water gagings, and steam distillation is collected volatile oil, gets component 1; Medicinal liquid after distillation device is in addition collected, and residue and Gypsum Fibrosum, Rhizoma Cimicifugae add 10 times of water gagings and decoct 3 times, and each 1 hour, filtration, merging filtrate is concentrated into relative density 1.05～1.15 (70～85 ℃ of hot surveys), leaves standstill, and filters, and filtrating is concentrated, dry, gets component 2.
Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Cyathulae, Rhizoma Coptidis are added 8 times of amount ethanol extractions of 60% 3 times, each 1 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 3.
Merge component 2 and component 3, dry granulation, spray adds component 1, and mixing promptly gets.

Claims (23)

1. the pharmaceutical composition with analgesic, antiinflammatory and analgesic activity is characterized in that the crude drug of this pharmaceutical composition is: constitute ministerial drug as Gypsum Fibrosum 10-60 part of monarch drug with as Rhizoma Chuanxiong 5-15 part of ministerial drug or by Rhizoma Chuanxiong 5-15 part and Radix Angelicae Dahuricae 5-25 part.
2. pharmaceutical composition as claimed in claim 1 is characterized in that the weight portion of each crude drug is: 25 parts of Gypsum Fibrosum, 10 parts of Rhizoma Chuanxiongs, 15 parts of the Radixs Angelicae Dahuricae.
3. preparation of drug combination method according to claim 1 or claim 2, wherein:
When Gypsum Fibrosum, Rhizoma Chuanxiong and the Radix Angelicae Dahuricae were crude drug, this method for preparing was:
1) take by weighing each crude drug, subsequent use;
2) Rhizoma Chuanxiong, the Radix Angelicae Dahuricae of said proportioning added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 1;
3) Gypsum Fibrosum with said proportioning adds 8～15 times of water gagings decoctions 1～3 time, and each 1～3 hour, filtration merged all filtratings, is concentrated into 70～85 ℃ of hot relative densities 1.05～1.15 of surveying, and leaves standstill, and filters, and it is concentrated, dry to filtrate, and gets component 2.
4) merge component 1 and component 2, will be ground into powder, mix homogeneously promptly makes this active ingredient in pharmaceutical;
Perhaps
When Gypsum Fibrosum, when Rhizoma Chuanxiong is crude drug, this method for preparing comprises:
1) take by weighing each crude drug, subsequent use;
2) Rhizoma Chuanxiong of said proportioning is added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 1;
3) Gypsum Fibrosum with said proportioning adds 8～15 times of water gagings decoctions 1～3 time, and each 1～3 hour, filtration merged all filtratings, is concentrated into 70～85 ℃ of hot relative densities 1.05～1.15 of surveying, and leaves standstill, and filters, and it is concentrated, dry to filtrate, and gets component 2;
4) merge component 1 and component 2, will be ground into powder, mix homogeneously promptly makes this active ingredient in pharmaceutical.
4. claim 1 or 2 said pharmaceutical compositions have the purposes in the medicine of analgesic, antiinflammatory and analgesic activity in preparation.
5. pharmaceutical composition with analgesic, antiinflammatory and analgesic activity, it is the basis with the crude drug of claim 1, also adds one and Rhizoma Cimicifugae 5-20 part in crude drug Radix Cyathulae 5-25 part or Radix Achyranthis Bidentatae 5-25 part.
6. pharmaceutical composition as claimed in claim 5 is characterized in that the weight portion of each crude drug is: 10 parts of in 15 parts of combination that 25 parts of Gypsum Fibrosum, 10 parts of Rhizoma Chuanxiongs and the Radix Angelicae Dahuricae are 15 parts or 10 parts of Rhizoma Chuanxiongs, 15 parts of Radix Cyathulaes or the Radix Achyranthis Bidentataes one and Rhizoma Cimicifugaes.
7. like claim 5 or 6 described preparation of drug combination methods, wherein:
In Gypsum Fibrosum, Rhizoma Chuanxiong and the Radix Angelicae Dahuricae, Radix Cyathulae or Radix Achyranthis Bidentatae one, when being crude drug with Rhizoma Cimicifugae, this method for preparing comprises:
1) take by weighing each crude drug, subsequent use;
2) Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Cyathulae or the Radix Achyranthis Bidentatae of said proportioning added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 1;
3) Gypsum Fibrosum, the Rhizoma Cimicifugae with said proportioning adds 8～15 times of water gagings decoctions 1～3 time, and each 1～3 hour, filtration merged all filtratings, is concentrated into 70～85 ℃ of hot relative densities 1.05～1.15 of surveying, and leaves standstill, and filters, and it is concentrated, dry to filtrate, and gets component 2;
4) merge component 1 and component 2, be ground into powder, mix homogeneously promptly makes this active ingredient in pharmaceutical;
Perhaps
In Gypsum Fibrosum, Rhizoma Chuanxiong, Radix Cyathulae or Radix Achyranthis Bidentatae one, when being crude drug with Rhizoma Cimicifugae, this method for preparing comprises:
1) take by weighing each crude drug, subsequent use;
2) Rhizoma Chuanxiong, Radix Cyathulae or the Radix Achyranthis Bidentatae of said proportioning added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 1;
3) Gypsum Fibrosum, the Rhizoma Cimicifugae with said proportioning adds 8～15 times of water gagings decoctions 1～3 time, and each 1～3 hour, filtration merged all filtratings, is concentrated into 70～85 ℃ of hot relative densities 1.05～1.15 of surveying, and leaves standstill, and filters, and it is concentrated, dry to filtrate, and gets component 2;
4) merge component 1 and component 2, be ground into powder, mix homogeneously promptly makes this active ingredient in pharmaceutical.
8. pharmaceutical composition as claimed in claim 5 also adds Rhizoma Coptidis 1-10 part or Radix Rehmanniae 5-30 part in its crude drug.
9. pharmaceutical composition as claimed in claim 8 is characterized in that the weight portion of each crude drug is: 10 parts of in 15 parts of in 15 parts of combination that 25 parts of Gypsum Fibrosum, 10 parts of Rhizoma Chuanxiongs and the Radix Angelicae Dahuricae are 15 parts or 10 parts of Rhizoma Chuanxiongs, 15 parts of Radix Cyathulaes or the Radix Achyranthis Bidentataes one, 3 parts of Rhizoma Coptidis or the Radix Rehmanniae one and Rhizoma Cimicifugaes.
10. like claim 8 or 9 said preparation of drug combination methods, wherein:
When one in one in Gypsum Fibrosum, Rhizoma Chuanxiong and the Radix Angelicae Dahuricae, Radix Cyathulae or the Radix Achyranthis Bidentatae, Rhizoma Coptidis or the Radix Rehmanniae and Rhizoma Cimicifugae were crude drug, this method for preparing comprised:
1) take by weighing each crude drug, subsequent use;
2) Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Cyathulae or Radix Achyranthis Bidentatae, Rhizoma Coptidis or the Radix Rehmanniae of said proportioning added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 1;
3) Gypsum Fibrosum, the Rhizoma Cimicifugae with said proportioning adds 8～15 times of water gagings decoctions 1～3 time, and each 1～3 hour, filtration merged all filtratings, is concentrated into 70～85 ℃ of hot relative densities 1.05～1.15 of surveying, and leaves standstill, and filters, and it is concentrated, dry to filtrate, and gets component 2;
4) merge component 1 and component 2, be ground into powder, mix homogeneously promptly makes this active ingredient in pharmaceutical;
Perhaps
When one in one in Gypsum Fibrosum, Rhizoma Chuanxiong, Radix Cyathulae or the Radix Achyranthis Bidentatae, Rhizoma Coptidis or the Radix Rehmanniae and Rhizoma Cimicifugae were crude drug, this method for preparing comprised:
1) take by weighing each crude drug, subsequent use;
2) Rhizoma Chuanxiong, Radix Cyathulae or Radix Achyranthis Bidentatae, Rhizoma Coptidis or the Radix Rehmanniae of said proportioning added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 1;
3) Gypsum Fibrosum, the Rhizoma Cimicifugae with said proportioning adds 8～15 times of water gagings decoctions 1～3 time, and each 1～3 hour, filtration merged all filtratings, is concentrated into 70～85 ℃ of hot relative densities 1.05～1.15 of surveying, and leaves standstill, and filters, and it is concentrated, dry to filtrate, and gets component 2;
4) merge component 1 and component 2, be ground into powder, mix homogeneously promptly makes this active ingredient in pharmaceutical.
11. pharmaceutical composition according to claim 1 also adds Herba Asari 3-10 part or Rhizoma Et Radix Notopterygii 5-15 part in its crude drug.
12. pharmaceutical composition as claimed in claim 11 is characterized in that the weight portion of each crude drug is: in 10 parts of combination that 25 parts of Gypsum Fibrosum, 10 parts of Rhizoma Chuanxiongs and the Radix Angelicae Dahuricae are 15 parts or 10 parts of Rhizoma Chuanxiongs, 6 parts of Herba Asaris or the Rhizoma Et Radix Notopterygiis one.
13. like claim 11 or 12 described preparation of drug combination methods, wherein:
When being crude drug for one in Gypsum Fibrosum, Rhizoma Chuanxiong and the Radix Angelicae Dahuricae, Herba Asari or the Rhizoma Et Radix Notopterygii, this method for preparing comprises:
1) take by weighing each crude drug, subsequent use;
2) Herba Asari of said weight proportion or Rhizoma Et Radix Notopterygii are added water and extract volatile oil in right amount, component 1; Medicinal liquid after distillation device is in addition collected, and the Gypsum Fibrosum of residue and said weight proportion adds 8～15 times of water gagings and decocts 1～3 time, each 1～3 hour, filters; Merge all filtratings, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill; Filter, filtrating is concentrated, dry, gets component 2;
3) Rhizoma Chuanxiong, the Radix Angelicae Dahuricae of said proportioning added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 3;
4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing promptly makes this active ingredient in pharmaceutical;
Perhaps
When being crude drug for one in Gypsum Fibrosum, Rhizoma Chuanxiong, Herba Asari or the Rhizoma Et Radix Notopterygii, this method for preparing comprises:
1) take by weighing each crude drug, subsequent use;
2) Herba Asari of said weight proportion or Rhizoma Et Radix Notopterygii are added water and extract volatile oil in right amount, component 1; Medicinal liquid after distillation device is in addition collected, and the Gypsum Fibrosum of residue and said weight proportion adds 8～15 times of water gagings and decocts 1～3 time, each 1～3 hour, filters; Merge all filtratings, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill; Filter, filtrating is concentrated, dry, gets component 2;
3) Rhizoma Chuanxiong of said proportioning is added the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 3;
4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing promptly makes this active ingredient in pharmaceutical.
14. pharmaceutical composition as claimed in claim 11 also adds Rhizoma Coptidis 1-10 part or Radix Rehmanniae 5-30 part in its crude drug.
15. pharmaceutical composition as claimed in claim 14 is characterized in that the weight portion of each crude drug is: in 15 parts of in 10 parts of combination that 25 parts of Gypsum Fibrosum, 10 parts of Rhizoma Chuanxiongs and the Radix Angelicae Dahuricae are 15 parts or 10 parts of Rhizoma Chuanxiongs, 6 parts of Herba Asaris or the Rhizoma Et Radix Notopterygiis one, 3 parts of Rhizoma Coptidis or the Radix Rehmanniae one.
16. like claim 14 or 15 described preparation of drug combination methods, wherein:
When being crude drug for one in one in Gypsum Fibrosum, Rhizoma Chuanxiong and the Radix Angelicae Dahuricae, Herba Asari and the Rhizoma Et Radix Notopterygii and Rhizoma Coptidis and the Radix Rehmanniae, this method for preparing comprises:
1) take by weighing each crude drug, subsequent use;
2) Herba Asari of said weight proportion or Rhizoma Et Radix Notopterygii are added water and extract volatile oil in right amount, component 1; Medicinal liquid after distillation device is in addition collected, and the Gypsum Fibrosum of residue and said weight proportion adds 8～15 times of water gagings and decocts 1～3 time, each 1～3 hour, filters; Merge all filtratings, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill; Filter, filtrating is concentrated, dry, gets component 2;
3) one in the Rhizoma Chuanxiong of said proportioning and the Radix Angelicae Dahuricae and Rhizoma Coptidis and the Radix Rehmanniae is mixed, adds the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 3;
4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing promptly makes this active ingredient in pharmaceutical;
Perhaps
When being crude drug for one in one in Gypsum Fibrosum, Rhizoma Chuanxiong, Herba Asari and the Rhizoma Et Radix Notopterygii and Rhizoma Coptidis and the Radix Rehmanniae, this method for preparing comprises:
1) take by weighing each crude drug, subsequent use;
2) Herba Asari of said weight proportion or Rhizoma Et Radix Notopterygii are added water and extract volatile oil in right amount, component 1; Medicinal liquid after distillation device is in addition collected, and the Gypsum Fibrosum of residue and said weight proportion adds 8～15 times of water gagings and decocts 1～3 time, each 1～3 hour, filters; Merge all filtratings, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill; Filter, filtrating is concentrated, dry, gets component 2;
3) one in the Rhizoma Chuanxiong of said proportioning and Rhizoma Coptidis and the Radix Rehmanniae is mixed, adds the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 3;
4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing promptly makes this active ingredient in pharmaceutical.
17. pharmaceutical composition as claimed in claim 1, also add in its raw medicinal material in Radix Cyathulae 5-25 part and Radix Achyranthis Bidentatae 5-25 part one and Herba Asari 3-10 part and Rhizoma Et Radix Notopterygii 5-15 part one, with Rhizoma Cimicifugae 5-20 part.
18., it is characterized in that the weight portion of each crude drug is: 10 parts of the combination that 25 parts of Gypsum Fibrosum, 10 parts of Rhizoma Chuanxiongs and the Radix Angelicae Dahuricae are 15 parts or 10 parts of Rhizoma Chuanxiongs, 10 parts of Rhizoma Cimicifugaes, Radix Cyathulae or 15 parts of Radix Achyranthis Bidentataes, 6 parts of Herba Asaris or Rhizoma Et Radix Notopterygiis like the said pharmaceutical composition of claim 17.
19. like claim 17 or 18 described preparation of drug combination methods, wherein:
When one in one in Gypsum Fibrosum, Rhizoma Chuanxiong and the Radix Angelicae Dahuricae, Radix Cyathulae and the Radix Achyranthis Bidentatae, Herba Asari and the Rhizoma Et Radix Notopterygii and Rhizoma Cimicifugae were crude drug, this method for preparing comprised:
1) take by weighing each crude drug, subsequent use;
2) Herba Asari of said weight proportion or Rhizoma Et Radix Notopterygii are added water and extract volatile oil in right amount, component 1; Medicinal liquid after distillation device is in addition collected, and the Gypsum Fibrosum of residue and said weight proportion, Rhizoma Cimicifugae add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filters; Merge all filtratings, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill; Filter, filtrating is concentrated, dry, gets component 2;
3) one in the Radix Cyathulae of said proportioning and the Radix Achyranthis Bidentatae is mixed with Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, adds the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 3;
4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing promptly makes this active ingredient in pharmaceutical.
Perhaps
When one in one in Gypsum Fibrosum, Rhizoma Chuanxiong, Radix Cyathulae and the Radix Achyranthis Bidentatae, Herba Asari and the Rhizoma Et Radix Notopterygii and Rhizoma Cimicifugae were crude drug, this method for preparing comprised:
1) take by weighing each crude drug, subsequent use;
2) Herba Asari of said weight proportion or Rhizoma Et Radix Notopterygii are added water and extract volatile oil in right amount, component 1; Medicinal liquid after distillation device is in addition collected, and the Gypsum Fibrosum of residue and said weight proportion, Rhizoma Cimicifugae add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filters; Merge all filtratings, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill; Filter, filtrating is concentrated, dry, gets component 2;
3) with the Rhizoma Chuanxiong of said proportioning; A mixing in Radix Cyathulae or the Radix Achyranthis Bidentatae adds 6～12 times of amount ethanol extractions of 40%～80% 1～4 time, each 0.5～2 hour, filter, merging filtrate, decompression recycling ethanol, drying under reduced pressure below 60 ℃, component 3.
4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing promptly makes this active ingredient in pharmaceutical.
20. pharmaceutical composition as claimed in claim 1 also adds one and Rhizoma Cimicifugae 5-20 part in in Radix Cyathulae or Radix Achyranthis Bidentatae 5-25 part one, Herba Asari 3-10 part or Rhizoma Et Radix Notopterygii 5-15 part one, Rhizoma Coptidis 1-10 part or Radix Rehmanniae 5-30 part in its raw medicinal material.
21., it is characterized in that the weight portion of each crude drug is: 15 parts of the combination that 25 parts of Gypsum Fibrosum, 10 parts of Rhizoma Chuanxiongs and the Radix Angelicae Dahuricae are 15 parts or 10 parts of Rhizoma Chuanxiongs, 10 parts of Rhizoma Cimicifugaes, Radix Cyathulae or 15 parts of Radix Achyranthis Bidentataes, 6 parts of Herba Asaris or 10 parts of Rhizoma Et Radix Notopterygiis, 3 parts of Rhizoma Coptidis or Radix Rehmanniae like the said pharmaceutical composition of claim 20.
22. like the method for preparing of claim 20 or 21 described medicines, wherein:
When one in one in one in Gypsum Fibrosum, Rhizoma Chuanxiong and the Radix Angelicae Dahuricae, Radix Cyathulae or the Radix Achyranthis Bidentatae, Herba Asari or the Rhizoma Et Radix Notopterygii, Rhizoma Coptidis or the Radix Rehmanniae and Rhizoma Cimicifugae were crude drug, this method for preparing comprised:
1) take by weighing each crude drug, subsequent use;
2) Herba Asari of said weight proportion or Rhizoma Et Radix Notopterygii are added water and extract volatile oil in right amount, component 1; Medicinal liquid after distillation device is in addition collected, and the Gypsum Fibrosum of residue and said weight proportion, Rhizoma Cimicifugae add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filters; Merge all filtratings, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill; Filter, filtrating is concentrated, dry, gets component 2;
3) one in one in the Radix Cyathulae of said proportioning or the Radix Achyranthis Bidentatae, Rhizoma Coptidis or the Radix Rehmanniae and Rhizoma Chuanxiong, the Radix Angelicae Dahuricae are mixed, add the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour; Filter merging filtrate, decompression recycling ethanol; Drying under reduced pressure below 60 ℃ gets component 3;
4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing promptly makes this active ingredient in pharmaceutical;
Perhaps
In one in one in Gypsum Fibrosum, Rhizoma Chuanxiong, Radix Cyathulae or the Radix Achyranthis Bidentatae, Herba Asari or the Rhizoma Et Radix Notopterygii, Rhizoma Coptidis or Radix Rehmanniae one; And Rhizoma Cimicifugae is when being crude drug, and this method for preparing comprises:
1) take by weighing each crude drug, subsequent use;
2) Herba Asari of said weight proportion or Rhizoma Et Radix Notopterygii are added water and extract volatile oil in right amount, component 1; Medicinal liquid after distillation device is in addition collected, and the Gypsum Fibrosum of residue and said weight proportion, Rhizoma Cimicifugae add 8～15 times of water gagings and decoct 1～3 time, each 1～3 hour, filters; Merge all filtratings, be concentrated into 70～85 ℃ of heat and survey relative density 1.05～1.15, leave standstill; Filter, filtrating is concentrated, dry, gets component 2;
3), add the ethanol extraction 1～4 time of 6～12 times of amounts 40%～80%, each 0.5～2 hour with a mixing in Rhizoma Chuanxiong, Radix Cyathulae or the Radix Achyranthis Bidentatae of said proportioning, Rhizoma Coptidis or the Radix Rehmanniae; Filter merging filtrate, decompression recycling ethanol; Drying under reduced pressure below 60 ℃ gets component 3;
4) merge component 2 and component 3, pulverize, spray adds component 1, and mixing promptly makes this active ingredient in pharmaceutical.
23. have the purposes in the medicine of analgesic, antiinflammatory and analgesic activity in preparation like claim 5,6,8,9,11,12,14,15,17,18,20 or 21 arbitrary described pharmaceutical compositions.
CN2012100280889A 2008-03-25 2008-03-25 Medicinal composition with antipyretic, anti-inflammatory and analgesic effects and preparation method thereof Pending CN102552354A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104906402A (en) * 2015-07-06 2015-09-16 苗怡文 Chinese medicine preparation for treating refractory headache and preparation method thereof
CN111671849A (en) * 2020-07-13 2020-09-18 刘世军 Full-ingredient formula of fire-clearing toothache-eliminating granules for treating periodontitis and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
盛增秀 等: "《医学类聚》", 31 December 2006 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104906402A (en) * 2015-07-06 2015-09-16 苗怡文 Chinese medicine preparation for treating refractory headache and preparation method thereof
CN111671849A (en) * 2020-07-13 2020-09-18 刘世军 Full-ingredient formula of fire-clearing toothache-eliminating granules for treating periodontitis and preparation method thereof

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