KR20190094937A - A drug for treating toothache and its preparation method - Google Patents

Abstract

The present invention discloses a medicine for treating toothache and a method for manufacturing the same. The medicine for treating toothache contains: 15 to 25 parts by weight of Rhizoma Alismatis; 10 to 25 parts by weight of Sargent gloryvine; 13 to 20 parts by weight of Astragalus propinquus; 12 to 20 parts by weight of Angelica sinensis; and 5 to 15 parts by weight of white Radix ginseng. The medicine for treating toothache according to the present invention has different components compared to a medicine of the prior art, and thus can overcome disadvantages of the medicine of the prior art.

Description

Toothache treatment drug and preparation method thereof {A DRUG FOR TREATING TOOTHACHE AND ITS PREPARATION METHOD}

The present invention relates to the field of drugs, in particular drugs for the treatment of toothaches and methods for their preparation.

Toothache is mainly caused by infection of the dental pulp (tooth nerve) due to gingivitis and periodontitis, decayed caries (tooth decay) or broken teeth. Specifically, toothache occurs for the following reasons: lack of interest in oral hygiene; Long-term irritation to the teeth by soft scale and hard tartar formed by food residues, bacteria, etc. around the teeth; Wrong brushing habits; And vitamin deficiency. Toothache is one of the common symptoms of several types of dental and periodontal disease, including swelling of the gums, dysmasesia or intermittent toothaches, pain from cold and heat irritation, swollen cheeks, etc. It is characterized by toothache as a major clinical symptom accompanied by symptom.

The causes of toothache are classified into the following types:

1) wind-cold attack

Treatments for these toothaches: Warm channels to remove wind, remove chills and relieve pain.

2) wind-heat attack

Treatment for these toothaches: Clearing heat to clear wind and relieve pain.

3) exuberance of stomach fire

Treatment for these toothaches: Empty the stomach, remove extreme heat, relieve swelling and pain.

4) flaming-up of asthenic fire

Therapies for these toothaches: Eliminate extreme heat to strengthen yin, nourish the kidneys and relieve pain.

However, for any type of toothache, the therapeutic effects that depend on the above treatments are not ideal as a single therapeutic effect. In addition, current drugs have other toxicity and side effects. Therefore, there is an urgent need for a novel toothache treatment drug to overcome this drawback.

In view of the above problems, the present invention provides a drug for treating toothache which can solve the above problem or at least part of the above problem, which is used in the prior art to overcome the shortcomings of the poor therapeutic effect of the drug.

According to a first aspect, the present invention provides 15 to 25 parts by weight of Rhizoma Alismatis, 10 to 25 parts by weight of Sargent gloryvine, 13 to 20 parts by weight of Astragalus membranaceus, 12 to 20 parts by weight of Angelica sinensis And 5 to 15 parts by weight of white radix (white Radix Ginseng).

The present invention discloses a drug for treating toothache and a method of preparing the same. Drugs for treating toothache according to the present invention have different components compared to drugs of the prior art, and can overcome the drawbacks of the drugs of the prior art.

In one embodiment of the present invention, the drug for treating toothache comprising 15 to 25 parts by weight of tackifier, 10 to 25 parts by weight of red light, 13 to 20 parts by weight of Astragalus, 12 to 20 parts by weight of Angelica and 5 to 15 parts by weight of white ginseng to provide.

In addition, the drug further comprises 20 to 30 parts by weight of the leucine (Fructus Amomi).

In addition, the drug further comprises 12 to 18 parts by weight of a red suit (Radix Paeoniae Rubra).

The above nutmeg and peony are only some specific examples, and are not intended to be limiting, for example, wolfberry fruit, Gynostemma pentaphyllum, 12 Semen Astragali Complanati, Radix Dipsaci Other ingredients are also possible, such as Herba Eclipta and Rutus Ligustri Lucidi. Other possible materials will not be described in detail.

Optionally, in one embodiment of the present invention, as materials for activating blood circulation, for example, Carcuma longa, Ligusticum chuanxiong Hort, Radix Salviae Miltiorrhizae and Evening Primrose may be added. Can be.

In addition, in one embodiment of the present invention, in order to enhance the pharmacological effect, the drug may be, for example, Gardenia (Fructus Gardeniae), Flos Chrysanthemi, Semen Cassiae, Cortex fraxini, Ginseng ( Radix Sophorae Flavescentis), Chrysanthemi Indici (Flos Chrysanthemi Indici), Andrographis paniculata and the like may further include a material for clearing.

In addition, the drug may further include materials such as, for example, Herba Sedi, Abrus Herb, etc. to remove moisture and promote diuresis.

In addition, the drug may further comprise a material such as, for example, pepper to warm the interior.

In one embodiment of the invention, the formulation of the drug is a film-coated tablet, a sugar coated tablet, an enteric coated tablet, a dispersible tablet, a capsule, a granule, a decoction At least one of a mixture, a syrup, a vinum, an injection, an oral solution and an oral turbid liquid.

In one embodiment of the invention, optionally, the drug has an oral-dose formulation.

In one embodiment of the invention, optionally, the oral-dose formulation comprises a tablet, capsule, pill, injectable, sustained release preparation and controlled release preparation.

The drug of the embodiment provided in the present invention or a pharmaceutical composition containing the same may be administered in unit dosage form through the intestine, nasal cavity, oral mucosa, eyes, lungs, airways, skin, rectum, or the like, oral administration, intravenous injection, muscle It can be administered by internal injection and subcutaneous injection.

Dosage formulations may be liquid formulations, solid formulations or semi-solid formulations. Liquid formulations may be solutions, emulsions, suspensions, injections (including injection water, powder injections and transfusions), eye drops, nasal drops, lotions and liniments; Solid dosage forms include tablets (uncoated tablets, enteric coated tablets, buccal tablets, dispersible tablets, chewable tablets, effervescent tablets, orally disintegrating tablets). ), Capsules (including hard capsules, soft capsules, enteric capsules), granules, powders, pellets, dropping pills, suppositories, film agents, pastes, aerosols Can be sprays, etc .; Semi-solid formulations may be ointments, gels, pastes and the like. The formulation of the drug is preferably tablets, capsules, pills and injections.

Drugs according to embodiments of the invention can be prepared in conventional preparations, sustained release preparations, controlled release preparations, targeting preparations and various granule dosage formulations.

In one embodiment of the present invention, various excipients can be used to prepare the drugs of the present invention into tablets, such as diluents, binders, humectants, disintegrants, lubricants and glidants. Diluents may be starch, dextrin, sucrose, glucose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose, calcium sulfate, calcium hydrogen phosphate, calcium carbonate and the like; The repair agent may be water, ethanol, isopropanol and the like; The binder is starch pulp, dextrin, syrup, honey, glucose solution, microcrystalline cellulose, gum arabic pulp, gelatin pulp, sodium carboxymethyl cellulose and methyl cellulose. Can; Disintegrants can be dry starch, microcrystalline cellulose, low-substituted hydroxypropylcellulose; Lubricants and lubricants can be talc, silica, stearate, liquid paraffin, and the like.

In addition, the drug may also be a coated tablet, such as sugar coated tablets, film coated tablets, enteric coated tablets, and the like.

If the drug is prepared in capsules, the active ingredient may be prepared in granules or pills with the addition of diluents, binders and disintegrants, which are then placed in hard capsules or soft capsules.

If the drug is prepared as an injection, the solvent may be prepared from water, ethanol, isopropanol, propylene glycol or mixtures thereof. In addition, an appropriate amount of solubilizing agent, cosolvent, pH adjusting agent, osmotic pressure adjusting agent may be added.

The drug may also be added with colorants, preservatives, perfumes, corrigents or other additives.

In an embodiment of the present invention, there is provided a method of preparing the drug, comprising the following steps:

The first step: weighing 15 to 25 parts by weight of tack yarn, 10 to 25 parts by weight of red lamp, 13 to 20 parts by weight of anggi, 12 to 20 parts by weight of Angelica and 5 to 15 parts by weight of white ginseng;

Second step: mixing the raw materials to obtain a mixture, grinding the mixture and screening with 100 mesh sieve;

Third step: adding water to the screened raw material and soaking for 6 to 8 hours;

Fourth step: heating the immersed raw material for 40 minutes; And

5th step: filtering to remove dregs and obtaining lixivium as a target drug.

In the following, some specific embodiments of a method of preparing a drug for treating toothache are provided.

Example 1

The first step: weighing 15 to 25 parts by weight of tack yarn, 10 to 25 parts by weight of red lamp, 13 to 20 parts by weight of anggi, 12 to 20 parts by weight of Angelica and 5 to 15 parts by weight of white ginseng;

Second step: mixing the raw materials to obtain a mixture, pulverizing the mixture and screening with 100 mesh sieve;

Third step: adding water to the screened raw material and immersing for 6 hours;

Fourth step: adding 10 ml of water every 20 minutes while heating the soaked raw material for 40 minutes; And

Step 5: filtering to remove debris to obtain an effluent as a target drug.

Example 2

The first step: weighing 15 parts by weight of tack, 10 parts by weight of red lamps, 13 parts by weight of astragalus, 18 parts by weight of Angelica, 20 parts by weight of white beans, and 12 parts by weight of white ginseng;

Second step: pulverizing the raw material into powder, sieving the powder into a sieve of 100 mesh and mixing uniformly to obtain fine powder;

Third step: immersing the semal in water for at least 8 hours until it is completely submerged;

Step 4: decanting the resultant (resultant) twice each at 30 ° C. for 40 minutes and filtering to obtain two filtrates;

5th step: mixing the two filtrates and left at room temperature for 30 minutes to obtain a supernate, and concentrating the supernatant in vacuo to obtain a thick paste; And

Sixth step; Drying the thick paste to pulverize it, and uniformly mixing the pulverized result with the semal and adjuvant material in an appropriate proportion to obtain a target drug.

Example 3

The first step: weighing 25 parts by weight of taxi, 10 parts by weight of red light, 18 parts by weight of astragalus, 18 parts by weight of Angelica, 30 parts by weight of Baekdugu, 15 parts by weight of Rhizoma Smilacis Glabrae and 12 parts by weight of White ginseng;

Second step: pulverizing the raw material into powder, sieving the powder into a sieve of 100 mesh, and uniformly mixing to obtain semal;

Third step: immersing the semal in water for at least 8 hours until it is completely submerged;

4th step: heating the immersed product at 30 degreeC for 40 minutes, and filtering to obtain a filtrate;

Step 5: leaving the filtrate at room temperature for 30 minutes to obtain a supernatant, and concentrating the supernatant in vacuo to obtain a thick paste; And

Sixth step; Drying the thick paste to pulverize it, and uniformly mixing the pulverized result with the semal and adjuvant material in an appropriate proportion to obtain a target drug.

Example 4

The first step: weighing 25 parts by weight of tack, 10 parts by weight of red light, 18 parts by weight of astragalus, 18 parts by weight of Angelica, 30 parts by weight of Baekdugu, 15 parts by weight of Tobokyeong and 12 parts by weight of White ginseng;

Second step: pulverizing the raw material into powder, sieving the powder into a sieve of 100 mesh, and uniformly mixing to obtain semal;

Third step: immersing the semal in water for at least 8 hours until it is completely submerged; And

Fourth step: heat the immersed product on low heat, boil three times and then decoct for another 30 minutes to obtain three tanning solutions, and mix the three tanning solutions to obtain a tanning agent.

Drugs for treating toothache according to the present invention have different components compared to drugs of the prior art, and can overcome the drawbacks of the drugs of the prior art.

Claims (5)

15 to 25 parts by weight of Rhizoma Alismatis, 10 to 25 parts by weight of Sargent gloryvine, 13 to 20 parts by weight of Astragalus membranaceus, 12 to 20 parts by weight of Angelica sinensis and 5 to 15 parts by weight of white ginseng Drugs for treating toothache, including (white Radix Ginseng). The drug for treating toothache of claim 1, further comprising 20 to 30 parts by weight of leucophagus (Fructus Amomi). The drug for treating toothache of claim 1, further comprising 12 to 18 parts by weight of a blue tooth (Radix Paeoniae Rubra). The formulation of claim 1, wherein the formulation of the drug is a film-coated tablet, a sugar coated tablet, an enteric coated tablet, a dispersible tablet, a capsule, a granule, A drug for the treatment of toothache, which is one or more of decoctions, mixtures, syrups, binums, injections, oral solutions and oral turbid liquids. A method of preparing a drug according to any one of claims 1 to 4, comprising the following steps:
The first step: weighing 15 to 25 parts by weight of tack yarn, 10 to 25 parts by weight of red lamp, 13 to 20 parts by weight of anggi, 12 to 20 parts by weight of Angelica and 5 to 15 parts by weight of white ginseng;
Second step: mixing the raw materials to obtain a mixture, grinding the mixture and screening with 100 mesh sieve;
Third step: adding water to the screened raw material and soaking for 6 to 8 hours;
Fourth step: heating the immersed raw material for 40 minutes; And
5th step: filtering to remove dregs and obtaining lixivium as a target drug.