KR20190083868A - A drug for treating cold and its preparation method - Google Patents

Abstract

The present invention discloses a medicine for treating a cold and a method for manufacturing the same. The medicine for treating the cold contains: 10 to 20 parts by weight of Bupleurum falcatum; 10 to 15 parts by weight of Phragmites communis; and 3 to 20 parts by weight of Scutellaria baicalensis. The medicine for treating the cold of the present invention has different ingredients compared to an existing medicine and can overcome deficiency of the existing medicine.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a drug for treating cold,

Field of the Invention The present invention relates to a pharmaceutical field, specifically, a medicament for treating a cold, and a method for producing the same.

Although cold is the most common acute respiratory infectious disease, a common cold is not really "common", and according to domestic and international data, a common cold can have serious social and economic burdens and can cause serious complications , And can even threaten the patient's life.

Currently, a cold is treated with a rational diet, a moderate amount of exercise, smoking cessation and a limited amount of alcohol, and psychological balance, or medication, but its therapeutic effect is not ideal. In addition, current drugs have other toxicities and side effects. Therefore, there is a desperate need for a novel medicament for treating a cold to overcome the drawbacks.

In view of the above problems, the present invention provides a medicament for treating a cold, which can solve at least part of the above problems or the above problems, and is used to overcome the drawbacks of poor treatment effects of conventional medicines.

According to a first aspect, the present invention provides a medicament for treating a cold, comprising Radix Bupleuri 10-20, Rhizoma Phragmitis 10-15 and Gold (Scutellaria baicalensis) 3-20 by weight .

According to a second aspect, the present invention provides a method of manufacturing a medicament according to any one of the above embodiments, comprising the steps of:

Step 1: weighing the weight of the roots 10-20, the roots 10-15 and the roots 3-20;

Step 2: Preparing the raw materials as decoction pieces, respectively, and cooking the pieces for 30-60 minutes for sterilization in a pressure cooker;

Step 3: Cool, filter with a 100-250 mesh filter cloth, and concentrate the resulting product to obtain a thick paste;

Step 4: Drying, crushing and sieving the thick paste to obtain the desired medicament.

The present invention discloses a medicament for treating a cold and a method for producing the medicament. The medicament for treating the cold according to the present invention has different components as compared with the conventional medicines, and can overcome the drawbacks of the conventional medicines.

In an embodiment of the present invention, there is provided a medicament for treating a cold, comprising parts 10-20, fimbriae 10-15 and golden 3-20 by weight.

The medicament further comprises fresh ginger 20-50 by weight.

In addition, the medicament further comprises Agastache rugosus 2-22 in parts by weight.

The fresh ginger and garnishing are only some specific embodiments and are not intended to be limiting, and other materials such as wolfberry fruit, Gynostemma pentaphyllum, 12 Semen Astragali Complanati, Radix Dipsaci Herba Eclipta and Fructus Ligustri Lucidi are also available. Other possible materials will not be disclosed in detail.

Alternatively, in embodiments of the present invention, substances that activate blood circulation, such as Carcuma longa, Ligusticum chuanxiong Hort, Radix Salviae Miltiorrhizae and Evening Primrose may be added.

In addition, in embodiments of the present invention, in order to improve the pharmacological effect, the medicament may contain a heat-removing substance such as Fructus Gardeniae, Flos Chrysanthemi, Semen Cassiae, cortex fraxini, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Andrographis paniculata, and the like.

In addition, the medicament may further include substances that remove toxic gas (damp) and promote diuretic, such as Herba Sedi, Abrus Herb, and the like.

In addition, the medicament may further comprise a substance for warming the inside, such as pepper.

In an embodiment of the invention, the dosage form of the medicament can be in the form of a film-coated tablet, dragees, enteric coated tablets, dispersible tablets, capsules, granules, decoctions, mixtures, syrups, vinum, injection, oral solution and oral turbid liquid.

In an embodiment of the invention, optionally, the medicament has an oral-dosage form.

In an embodiment of the invention, optionally, the oral-dosage form comprises a tablet, capsule, pill, injectable, sustained release preparation and controlled release formulation.

The medicament of the embodiment provided in the present invention or the medicament composition containing the medicament may be administered in unit dosage form through intestinal tract, nasal cavity, oral mucosa, eye, lung, respiratory tract, skin, rectum, Intravenous injection, intramuscular injection, and subcutaneous injection.

The dosage form may be a liquid dosage form, a solid dosage form, or a semi-solid dosage form. The liquid dosage forms may be in the form of solutions, emulsions, suspensions, injections (including mousses, powders and transfusions), eye drops, nasal drops, lotions and liniment. Have; The solid dosage forms may be in the form of tablets (including, but not limited to, uncoated tablets, enteric-coated tablets, buccal tablets, dispersible tablets, chewable tablets, effervescent tablets, orally disintegrating tablets ), Capsules (including hard capsules, soft capsules, enteric capsules), granules, powders, pellets, dropping pills, suppositories, films, paster, aerosols, ; And the semi-solid dosage form may be ointments, gels, pastes, and the like. The dosage form of the medicament is preferably tablets, capsules, pills and injections.

The medicament according to the embodiment of the present invention can be prepared by conventional preparations, sustained-release preparations, controlled-release preparations, targeting preparations, and various granular dosage formulations.

In embodiments of the invention, various excipients such as diluents, binders, wetting agents, disintegrants, lubricants and glidants may be used to prepare the medicament of the present invention by tablet. The diluent may be a starch, a dextrin, a sucrose, a glucose, a lactose, a mannitol, a sorbitol, a xylitol, a microcrystalline cellulose, a calcium sulfate, a calcium hydrogen phosphate, a calcium carbonate and the like; The wetting agent may be water, ethanol, isopropanol or the like; The binder may be a starch pulp, dextrin, syrup, honey, glucose solution, microcrystalline cellulose, gum arabic pulp, gelatin pulp, sodium carboxymethylcellulose and methylcellulose; The disintegrant may be dry starch, microcrystalline cellulose, low-substituted hydroxypropylcellulose; The lubricant and glidant may also be talc, silica, stearate, liquid paraffin, and the like.

The medicaments may also be coated tablets, such as sugar-coated tablets, film-coated tablets, intestinal coated tablets, and the like.

When the medicament is made into a capsule, the active ingredient can be made into granules or pellets with the addition of diluents, binders and disintegrants, which are then placed in hard capsules or soft capsules.

When the medicament is prepared with an injection, the solvent may be water, ethanol, isopropanol, propylene glycol, or a mixture thereof. In addition, a suitable amount of a solubilizing agent, a cosolvent, a pH adjusting agent, and an osmotic pressure adjusting agent may be added.

In addition, coloring agents, preservatives, perfumes, corrigents or other additives may be added to the medicament.

In an embodiment of the present invention, there is provided a method of making said medicament, comprising the steps of:

Step 1: weighing the weight of the roots 10-20, the roots 10-15 and the roots 3-20;

Step 2: Preparing the raw materials each as a molten slice, and cooking the molten slice for 30 to 60 minutes for sterilization in a pressure cooker;

Step 3: Cool, filter with 100-250 mesh filter cloth, and concentrate the resulting product to obtain a thick paste;

Step 4: Drying, crushing and sieving the thick paste to obtain the desired medicament.

Hereinafter, several specific embodiments of a method for producing a medicament for treating a cold are provided.

Example 1

Step 1: weighing parts No. 10-20, weevil 10-15 and gold 3-20 by weight, and mixing to obtain a mixture;

Step 2: Appropriate amount of water is added to the mixture of the Citrate, Cheney and Gold and soaked for 8 hours until they are soaked;

Step 3: 20 g fresh ginger is added to the mixture, heated at 30 캜 for 4 hours, and 10 ml of water added every 30 minutes;

Step 4: heating the mixture for 4 hours and allowing to stand at room temperature for 12 hours;

Step 5: Filter the mixture with a 100-250 mesh filter cloth and concentrate the resulting product to obtain a thick paste;

Step 6: Drying, crushing and sieving the thick paste to obtain the desired medicament.

Example 2

Step 1: weighing the wisteria, seeds, roots and gold and mixing them to obtain a mixture;

Step 2: Add an appropriate amount of water to the mixture of wax, seed, rouge and gold and soak for at least 8 hours until they are completely immersed;

Step 3: Add 20 g of Semen Armeniacae Amarum to the mixture, heat at 30 캜 for 4 hours, and add 10 ml of water every 30 minutes;

Step 4: heating the mixture for 4 hours and allowing to stand at room temperature for 12 hours;

Step 5: Filter the mixture with a 100-250 mesh filter cloth and concentrate the resulting product to obtain a thick paste;

Step 6: Drying, crushing and sieving the thick paste to obtain the desired medicament.

Example 3 (Preparation of granules)

Step 1: weighing the wisteria, seeds, roots and gold and mixing them to obtain a mixture;

Step 2: Add an appropriate amount of water to the mixture of wax, seed, rouge and gold and soak for at least 8 hours until they are completely immersed;

Step 3: Add 20 g of the passenger to the mixture, heat at 30 占 폚 for 4 hours, and add 10 ml of water every 30 minutes;

Step 4: heating the mixture for 4 hours and allowing to stand at room temperature for 12 hours;

Step 5: The mixture was filtered to obtain a filtrate, and the filtrate was concentrated in vacuo to obtain an extract having a relative density of 1.25 (at 60 DEG C), and the extract was mixed with three times the amount of dextrin to obtain a soft material Preparing granules with an oscillating granulator;

Step 6: Drying the granules at 65 占 폚 for 30 minutes, finishing the granules, sieving, removing a small amount of granules, and packaging.

Example 4 (Preparation of tablet)

Step 1: weighing parts No. 10-20, weevil 10-15 and gold 3-20 by weight, and mixing to obtain a mixture;

Step 2: adding an appropriate amount of water to the mixture of Sawn, roots and gold and soaking them for 8 hours until they are completely soaked;

Step 3: 20 g of Rhizoma Dioscoreae is added to the mixture, heated at 30 占 폚 for 4 hours, and 10 ml of water is added every 30 minutes;

Step 4: heating the mixture for 4 hours and allowing to stand at room temperature for 12 hours;

Step 5: The mixture was filtered to obtain a filtrate, and the filtrate was concentrated in vacuo to obtain an extract having a relative density of 1.25 (at 60 DEG C), and the extract was mixed with three times the amount of dextrin to obtain a soft material Preparing a granule with a vibrating granulator;

Step 6: Drying the granules at 65 占 폚 for 30 minutes and performing tabletting in a single-punch tablet press to obtain a tablet having a mass of 0.3 g.

The agents of the present invention may be administered independently or may be used in combination with other therapeutic agents. When there is a synergistic effect between the medicament of the present invention and other therapeutic agents, the dosage of the medicament of the present invention should be adjusted as necessary. The above embodiment is used for illustrative purposes only and is not used for limitation.

Example 5

Step 1: Carefully screening the seeds, roots and gold, washing the roots, weighing them according to a certain ratio and uniformly mixing to obtain the starting material;

Step 2: The starting material is added to purified water and the resulting product is cooked 3 to 4 times in 40-80 minutes at a time in a steam pressure cooker, the thick paste is extracted for each time of cooking and the thick paste is cut into 100-250 mesh Filtration with a filter cloth;

Step 3: uniformly mixing all thick pastes;

Step 4: Drying, crushing and sieving the uniformly mixed thick paste to obtain the desired medicament.

Claims (5)

Radix Bupleuri 10-20, Rhizoma Phragmitis 10-15 and Gold (Scutellaria baicalensis) 3-20 in parts by weight. The medicament according to claim 1, further comprising fresh ginger 20-50 by weight. The medicament according to claim 1, further comprising Agastache rugosus 2-22. The dosage form of claim 1, wherein the dosage form of the medicament is selected from the group consisting of film-coated tablets, dragees, enteric coated tablets, dispersible tablets, capsules, granules, decoctions, mixtures, syrups, , An injection, an oral solution, and an oral turbid liquid. A process for preparing a medicament according to any one of claims 1 to 4,
Step 1: weighing the weight of the roots 10-20, the roots 10-15 and the roots 3-20;
Step 2: Preparing the raw materials as decoction pieces, respectively, and cooking the pieces for 30-60 minutes for sterilization in a pressure cooker;
Step 3: Cool, filter with a 100-250 mesh filter cloth, and concentrate the resulting product to obtain a thick paste;
Step 4: drying, crushing and sieving the thick paste to obtain the desired medicament.