CN114404547B - Body resistance strengthening and blood stasis removing cream formula and application thereof - Google Patents
Body resistance strengthening and blood stasis removing cream formula and application thereof Download PDFInfo
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Abstract
The invention relates to a paste formula for strengthening body resistance and removing blood stasis and application thereof. The body resistance strengthening and blood stasis removing ointment is prepared from the following raw material medicines in parts by weight: 10-20 parts of angelica sinensis, 5-12 parts of peach kernel, 10-20 parts of ligusticum wallichii, 10-20 parts of salvia miltiorrhiza, 9-15 parts of rhodiola rosea, 5-12 parts of safflower, 5-12 parts of rhizoma cyperi, 3-9 parts of pseudo-ginseng, 5-12 parts of radix curcumae, 9-15 parts of radix paeoniae rubra, 9-15 parts of radix paeoniae alba, 3-8 parts of sandalwood, 10-20 parts of Chinese yam, 5-15 parts of prepared rhizome of rehmannia, 10-20 parts of polyporus umbellatus, 10-20 parts of poria cocos, 10-20 parts of raw semen coicis, 10-20 parts of fried semen coicis, 10-20 parts of raw astragalus mongholicus, 10-20 parts of radix astragali preparata, 10-20 parts of radix pseudostellariae and 3-9 parts of liquorice. The paste for strengthening body resistance and removing blood stasis can effectively intervene atherosclerosis, reduce plaque formation, lipid accumulation and free cholesterol formation, and has obvious improvement on the effect.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, and in particular relates to a body resistance strengthening and blood stasis removing paste formula and application thereof.
Background
Atherosclerosis belongs to arterial vascular disease in the whole body, and is easy to occur in a plurality of main arteries of a human body, and atherosclerosis of carotid artery, lower limb artery and coronary artery is the most common. Atherosclerotic lesions of the coronary vessels and of the arteries in the brain are the basic lesions that lead to a high risk of cardiovascular and cerebrovascular disease.
The traditional Chinese medicine considers that the disease position of atherosclerosis is mainly in blood vessels, the occurrence of the atherosclerosis is related to eating disorder, senile body weakness, seven-emotion internal injury and prolonged illness body weakness, and phlegm turbidity and blood stasis are blocked in the veins due to the factors, so that bones of four limbs and bones and internal organs of five viscera and six bowels are not nourished by moistening to cause the atherosclerosis to occur.
The clinical tests of the previous research (dawn phoenix, correlation analysis of atherosclerosis and blood stasis constitution and clinical effect observation of paste formula intervention, shanghai medical university) prove that the paste formula for strengthening body resistance and removing blood stasis has obvious improvement effect on traditional Chinese medicine symptoms such as complexion, lip color, pulse condition, chest distress symptom and the like of a patient with blood stasis constitution, can obviously improve the constitution state of the patient with blood stasis carotid atherosclerosis, has the effect of reducing carotid plaque, and has obvious relieving and treating effects on carotid atherosclerosis. The formula of the body resistance strengthening and blood stasis removing paste is formed by clinical addition and subtraction of basic formulas (90 g of peach kernel paste, 90g of grass safflower, 150g of fried rhizoma ligustici wallichii, 150g of red sage root, 120g of rhodiola root, 150g of aizoon stonecrop herb, 150g of red white peony root, 150g of whole angelica, 90g of wide radix curcumae, 150g of radix codonopsis pilosulae, 150g of uncooked cooked coix seed, 150g of common yam rhizome, 150g of pig tuckahoe, 150g of raw roasted astragalus root and 60g of liquorice), and for atherosclerosis patients with lung and defensive qi deficiency symptoms such as mental fatigue, hypodynamia, spontaneous perspiration, easy external infection and the like, qi-tonifying and exterior-strengthening medicines such as white ginseng, radix codonopsis pilosulae and radix sileris are added according to the cases; for patients with kidney deficiency symptoms such as soreness of waist and knees, dizziness, tinnitus, and soreness of neck and back, radix Achyranthis bidentatae, radix rehmanniae Preparata, herba cistanches, cortex Eucommiae, rhizoma Cibotii, and herba Taxilli can be added; can also be used for treating deficiency of heart-qi and restlessness due to night sleep, palpitation, timidity and easy convulsion, and optionally adding tranquilizing and tranquilizing medicines such as Poria, caulis Polygoni Multiflori, semen Ziziphi Spinosae, radix Polygalae Preparata, flos Albizziae, and cortex Albizziae; has the symptoms of vertigo and headache, and is added with liver calming, yang suppressing, collateral dredging and pain relieving medicines such as radix Puerariae, concha Margaritifera, concha Haliotidis, rhizoma Gastrodiae, ramulus Uncariae cum uncis, fructus Vitics Simplicifoliae, and retinervus Luffae fructus.
On the basis of earlier stage research, the inventor further adjusts and optimizes the compatibility of the prescription, and improves the curative effect of the ointment for strengthening the body resistance and removing blood stasis.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating atherosclerosis aiming at the defects in the prior art.
The invention further aims to provide application of the traditional Chinese medicine composition.
In order to achieve the first purpose, the invention adopts the technical scheme that:
a traditional Chinese medicine composition for treating atherosclerosis is prepared from the following raw material medicines in parts by weight: 10-20 parts of angelica sinensis, 5-12 parts of peach kernel, 10-20 parts of ligusticum wallichii, 10-20 parts of salvia miltiorrhiza, 9-15 parts of rhodiola rosea, 5-12 parts of safflower, 5-12 parts of rhizoma cyperi, 3-9 parts of pseudo-ginseng, 5-12 parts of radix curcumae, 9-15 parts of radix paeoniae rubra, 9-15 parts of radix paeoniae alba, 3-8 parts of sandalwood, 10-20 parts of Chinese yam, 5-15 parts of radix rehmanniae preparata, 10-20 parts of polyporus umbellatus, 10-20 parts of poria cocos, 10-20 parts of raw semen coicis, 10-20 parts of fried semen coicis, 10-20 parts of raw astragalus membranaceus, 10-20 parts of roasted astragalus membranaceus, 10-20 parts of radix pseudostellariae and 3-9 parts of liquorice.
As a preferred example, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 14-16 parts of angelica sinensis, 8-12 parts of peach kernel, 14-16 parts of ligusticum wallichii, 14-16 parts of salvia miltiorrhiza, 10-14 parts of rhodiola rosea, 8-10 parts of safflower, 8-10 parts of rhizoma cyperi, 5-7 parts of pseudo-ginseng, 8-10 parts of radix curcumae, 10-14 parts of radix paeoniae rubra, 10-14 parts of radix paeoniae alba, 5-6 parts of sandalwood, 14-16 parts of Chinese yam, 9-11 parts of prepared rhizome of rehmannia, 14-16 parts of polyporus umbellatus, 14-16 parts of poria cocos, 14-16 parts of raw semen coicis, 14-16 parts of fried semen coicis, 14-16 parts of raw astragalus membranaceus, 14-16 parts of roasted astragalus membranaceus, 14-16 parts of radix pseudostellariae and 5-7 parts of liquorice.
More preferably, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 15 parts of angelica, 9 parts of peach kernel, 15 parts of ligusticum wallichii, 15 parts of salvia miltiorrhiza, 12 parts of rhodiola rosea, 9 parts of safflower, 9 parts of rhizoma cyperi, 6 parts of pseudo-ginseng, 9 parts of radix curcumae, 12 parts of red paeony root, 12 parts of white paeony root, 5 parts of sandalwood, 15 parts of Chinese yam, 10 parts of prepared rehmannia root, 15 parts of polyporus umbellatus, 15 parts of poria cocos, 15 parts of raw coix seed, 15 parts of fried coix seed, 15 parts of raw astragalus mongholicus, 15 parts of fried astragalus mongholicus, 15 parts of radix pseudostellariae and 6 parts of liquorice.
As another preferred example, the traditional Chinese medicine composition further comprises a pharmaceutically conventional carrier.
More preferably, the pharmaceutically conventional carriers include emulsifiers, fillers, binders, humectants, disintegrants, absorption enhancers, flavoring agents, coloring agents, co-solvents.
As another preferable example, the dosage form of the traditional Chinese medicine composition is decoction, pills, tablets, mixtures, capsules, granules, powder, paste or wine.
More preferably, the Chinese medicinal composition is in the form of paste, and also comprises 10-20 parts of oxhide gelatin, 10-20 parts of donkey-hide gelatin, 20-30 parts of maltose, 20-30 parts of white honey and 20-30 parts of yellow wine; or further comprises 10-20 parts of yellow gelatin, 10-20 parts of Dong donkey-hide gelatin, 20-30 parts of xylitol and 20-30 parts of yellow wine.
In order to achieve the second object, the invention adopts the technical scheme that:
the application of the traditional Chinese medicine composition in preparing a medicine for treating atherosclerosis.
The atherosclerosis is carotid, lower limb, and/or coronary atherosclerosis.
The invention has the advantages that:
1. the body resistance strengthening and blood stasis removing paste formula is prepared by reducing and cutting basic traditional Chinese medicine formulas of four-monarch-seed decoction, eight-treasure decoction, peach kernel and safflower decoction, peach red four-medicine decoction and blood stasis removing decoction. The rhizoma ligustici wallichii, the rhodiola rosea, the pseudo-ginseng, the peach kernel, the safflower and the angelica have obvious effects of promoting blood circulation and removing blood stasis, and are monarch drugs. In addition, it is used in combination with blood circulation promoting, blood stasis dispelling and qi promoting herbs, such as lignum Santali albi, rhizoma Cyperi, radix Curcumae, saviae Miltiorrhizae radix, radix Paeoniae alba and radix Paeoniae Rubra, as ministerial drugs. The Chinese medicinal composition has effects in invigorating qi and spleen, and is used as adjuvant drug for regulating qi and blood. Prepared rehmannia root, radix rehmanniae Praeparata, radix Glycyrrhizae Praeparata, as a guiding drug, has the effects of replenishing blood and nourishing yin, and harmonizing the effects of the other drugs in the recipe. The medicines have synergistic effect and supplement each other to jointly play the effects of strengthening body resistance and eliminating evil, tonifying qi and nourishing blood, and activating blood and dissolving stasis.
2. Compared with the original prescription of the body resistance strengthening and blood stasis removing cream, the intervention effect of the prescription of the body resistance strengthening and blood stasis removing cream on atherosclerosis is obviously enhanced, and is stronger than that of western medicine atorvastatin tablets.
Detailed Description
The following provides a detailed description of specific embodiments of the present invention.
Example 1 preparation of decoction of the Chinese medicinal composition of the present invention
Weighing the following raw material medicines in parts by weight: 20 parts of angelica, 12 parts of peach kernel, 20 parts of ligusticum wallichii, 20 parts of salvia miltiorrhiza, 15 parts of rhodiola rosea, 5 parts of safflower, 5 parts of rhizoma cyperi, 3 parts of pseudo-ginseng, 5 parts of radix curcumae, 9 parts of radix paeoniae rubra, 15 parts of radix paeoniae alba, 8 parts of sandalwood, 20 parts of Chinese yam, 15 parts of radix rehmanniae preparata, 20 parts of polyporus umbellatus, 10 parts of poria cocos, 10 parts of raw semen coicis, 10 parts of fried semen coicis, 10 parts of raw radix astragali, 10 parts of fried radix astragali, 20 parts of radix pseudostellariae and 9 parts of liquorice, crushing, adding a proper amount of water, and decocting by a conventional method.
Example 2 preparation of decoction of the Chinese medicinal composition of the present invention
Weighing the following raw material medicines in parts by weight: 20 parts of angelica, 12 parts of peach kernel, 20 parts of ligusticum wallichii, 20 parts of salvia miltiorrhiza, 9 parts of rhodiola rosea, 5 parts of safflower, 5 parts of rhizoma cyperi, 3 parts of pseudo-ginseng, 12 parts of radix curcumae, 15 parts of radix paeoniae rubra, 15 parts of radix paeoniae alba, 8 parts of sandalwood, 10 parts of Chinese yam, 5 parts of radix rehmanniae preparata, 10 parts of polyporus umbellatus, 10 parts of poria cocos, 20 parts of raw semen coicis, 20 parts of fried semen coicis, 20 parts of raw radix astragali, 20 parts of fried radix astragali, 10 parts of radix pseudostellariae and 3 parts of liquorice, crushing, adding a proper amount of water, and decocting by a conventional method.
Example 3 preparation of decoction of the Chinese medicinal composition of the present invention (III)
Weighing the following raw material medicines in parts by weight: 20 parts of angelica, 12 parts of peach kernel, 20 parts of ligusticum wallichii, 10 parts of salvia miltiorrhiza, 9 parts of rhodiola rosea, 5 parts of safflower, 12 parts of rhizoma cyperi, 9 parts of pseudo-ginseng, 12 parts of radix curcumae, 9 parts of radix paeoniae rubra, 9 parts of radix paeoniae alba, 3 parts of sandalwood, 20 parts of Chinese yam, 15 parts of prepared rhizome of rehmannia, 20 parts of polyporus umbellatus, 10 parts of poria cocos, 10 parts of raw semen coicis, 10 parts of fried semen coicis, 20 parts of raw radix astragali, 20 parts of fried radix astragali, 20 parts of radix pseudostellariae and 3 parts of liquorice, crushing, adding a proper amount of water, and decocting by a conventional method.
Example 4 preparation of decoction of the Chinese medicinal composition of the present Invention (IV)
Weighing the following raw material medicines in parts by weight: 20 parts of angelica, 5 parts of peach kernel, 20 parts of ligusticum wallichii, 10 parts of salvia miltiorrhiza, 15 parts of rhodiola rosea, 5 parts of safflower, 12 parts of rhizoma cyperi, 3 parts of pseudo-ginseng, 12 parts of radix curcumae, 9 parts of radix paeoniae rubra, 15 parts of radix paeoniae alba, 3 parts of sandalwood, 20 parts of Chinese yam, 5 parts of radix rehmanniae preparata, 20 parts of polyporus umbellatus, 10 parts of poria cocos, 20 parts of raw semen coicis, 10 parts of fried semen coicis, 20 parts of raw radix astragali, 10 parts of fried radix astragali, 20 parts of radix pseudostellariae and 3 parts of liquorice, crushing, adding a proper amount of water, and decocting by a conventional method.
Example 5 preparation of decoction of the Chinese medicinal composition of the present invention (V)
Weighing the following raw material medicines in parts by weight: 10 parts of angelica, 12 parts of peach kernel, 10 parts of ligusticum wallichii, 20 parts of salvia miltiorrhiza, 9 parts of rhodiola rosea, 12 parts of safflower, 5 parts of rhizoma cyperi, 9 parts of pseudo-ginseng, 5 parts of radix curcumae, 15 parts of radix paeoniae rubra, 9 parts of radix paeoniae alba, 8 parts of sandalwood, 10 parts of Chinese yam, 15 parts of radix rehmanniae preparata, 10 parts of polyporus umbellatus, 20 parts of poria cocos, 10 parts of raw semen coicis, 20 parts of fried semen coicis, 10 parts of raw radix astragali, 20 parts of fried radix astragali, 10 parts of radix pseudostellariae and 9 parts of liquorice, crushing, adding a proper amount of water, and decocting by a conventional method.
Example 6 preparation of decoction of the Chinese medicinal composition of the present invention (six)
Weighing the following raw material medicines in parts by weight: 20 parts of angelica, 5 parts of peach kernel, 20 parts of ligusticum wallichii, 10 parts of salvia miltiorrhiza, 15 parts of rhodiola rosea, 5 parts of safflower, 12 parts of rhizoma cyperi, 3 parts of pseudo-ginseng, 12 parts of radix curcumae, 9 parts of radix paeoniae rubra, 15 parts of radix paeoniae alba, 3 parts of sandalwood, 20 parts of Chinese yam, 5 parts of radix rehmanniae preparata, 20 parts of polyporus umbellatus, 10 parts of poria cocos, 20 parts of raw semen coicis, 10 parts of fried semen coicis, 20 parts of raw radix astragali, 10 parts of fried radix astragali, 20 parts of radix pseudostellariae and 3 parts of liquorice, crushing, adding a proper amount of water, and decocting by a conventional method.
Example 7 preparation of decoction of the Chinese medicinal composition of the present invention (seven)
Weighing the following raw material medicines in parts by weight: 20 parts of angelica, 12 parts of peach kernel, 20 parts of ligusticum wallichii, 20 parts of salvia miltiorrhiza, 15 parts of rhodiola rosea, 5 parts of safflower, 5 parts of rhizoma cyperi, 3 parts of pseudo-ginseng, 12 parts of radix curcumae, 15 parts of radix paeoniae rubra, 15 parts of radix paeoniae alba, 8 parts of sandalwood, 10 parts of Chinese yam, 5 parts of radix rehmanniae preparata, 10 parts of polyporus umbellatus, 10 parts of poria cocos, 20 parts of raw semen coicis, 20 parts of fried semen coicis, 20 parts of raw radix astragali, 20 parts of fried radix astragali, 10 parts of radix pseudostellariae and 3 parts of liquorice, crushing, adding a proper amount of water, and decocting by a conventional method.
Example 8 preparation of decoction of the Chinese medicinal composition of the present invention (eight)
Weighing the following raw material medicines in parts by weight: 20 parts of angelica, 12 parts of peach kernel, 20 parts of ligusticum wallichii, 10 parts of salvia miltiorrhiza, 9 parts of rhodiola rosea, 5 parts of safflower, 5 parts of rhizoma cyperi, 3 parts of pseudo-ginseng, 12 parts of radix curcumae, 15 parts of radix paeoniae rubra, 15 parts of radix paeoniae alba, 8 parts of sandalwood, 10 parts of Chinese yam, 5 parts of radix rehmanniae preparata, 10 parts of polyporus umbellatus, 10 parts of poria cocos, 20 parts of raw semen coicis, 20 parts of fried semen coicis, 20 parts of raw radix astragali, 20 parts of fried radix astragali, 10 parts of radix pseudostellariae and 3 parts of liquorice, crushing, adding a proper amount of water, and decocting by a conventional method.
Example 9 preparation of decoction of the Chinese medicinal composition of the present invention (nine)
Weighing the following raw material medicines in parts by weight: 10 parts of angelica, 12 parts of peach kernel, 10 parts of ligusticum wallichii, 20 parts of salvia miltiorrhiza, 9 parts of rhodiola rosea, 12 parts of safflower, 5 parts of rhizoma cyperi, 3 parts of pseudo-ginseng, 12 parts of radix curcumae, 15 parts of radix paeoniae rubra, 15 parts of radix paeoniae alba, 8 parts of sandalwood, 10 parts of Chinese yam, 5 parts of radix rehmanniae preparata, 10 parts of polyporus umbellatus, 10 parts of poria cocos, 20 parts of raw semen coicis, 20 parts of fried semen coicis, 20 parts of raw radix astragali, 20 parts of fried radix astragali, 10 parts of radix pseudostellariae and 3 parts of liquorice, crushing, adding a proper amount of water, and decocting by a conventional method.
Example 10 preparation of decoction of the Chinese medicinal composition of the present invention (ten)
Weighing the following raw material medicines in parts by weight: 16 parts of angelica, 8 parts of peach kernel, 16 parts of szechuan lovage rhizome, 14 parts of salvia miltiorrhiza, 14 parts of rhodiola rosea, 8 parts of safflower, 10 parts of nutgrass galingale rhizome, 5 parts of sanchi, 10 parts of wide turmeric root-tuber, 10 parts of red paeony root, 14 parts of white paeony root, 5 parts of sandalwood, 16 parts of Chinese yam, 9 parts of prepared rehmannia root, 16 parts of polyporus umbellatus, 14 parts of tuckahoe, 16 parts of raw coix seed, 14 parts of fried coix seed, 16 parts of raw astragalus root, 14 parts of fried astragalus root, 16 parts of heterophylly falsestarwort root and 5 parts of liquorice, crushing, adding a proper amount of water, and decocting by a conventional method.
Example 11 preparation of decoction of the Chinese medicinal composition of the present invention (eleven)
Weighing the following raw material medicines in parts by weight: 14 parts of angelica, 12 parts of peach kernel, 14 parts of ligusticum wallichii, 16 parts of salvia miltiorrhiza, 10 parts of rhodiola rosea, 10 parts of safflower, 8 parts of rhizoma cyperi, 7 parts of pseudo-ginseng, 8 parts of radix curcumae, 14 parts of radix paeoniae rubra, 10 parts of radix paeoniae alba, 6 parts of sandalwood, 14 parts of Chinese yam, 11 parts of prepared rhizome of rehmannia, 14 parts of polyporus umbellatus, 16 parts of poria cocos, 14 parts of raw semen coicis, 16 parts of fried semen coicis, 14 parts of raw astragalus membranaceus, 16 parts of fried radix astragali, 14 parts of radix pseudostellariae and 7 parts of liquorice, crushing, adding a proper amount of water, and decocting by a conventional method.
Example 12 preparation of decoction of the Chinese medicinal composition of the present invention (twelve)
Weighing the following raw material medicines in parts by weight: 16 parts of angelica, 12 parts of peach kernel, 14 parts of szechuan lovage rhizome, 14 parts of salvia miltiorrhiza, 14 parts of rhodiola rosea, 10 parts of safflower, 8 parts of nutgrass galingale rhizome, 5 parts of pseudo-ginseng, 10 parts of wide turmeric root-tuber, 14 parts of red paeony root, 10 parts of white paeony root, 5 parts of sandalwood, 16 parts of Chinese yam, 11 parts of prepared rehmannia root, 14 parts of polyporus umbellatus, 14 parts of tuckahoe, 16 parts of raw coix seed, 16 parts of fried coix seed, 14 parts of raw astragalus root, 14 parts of roasted astragalus root, 16 parts of heterophylly falsestarwort root and 7 parts of liquorice, crushing, adding a proper amount of water, and decocting by a conventional method.
Example 13 preparation of decoction of the Chinese medicinal composition of the present invention (thirteen)
Weighing the following raw material medicines in parts by weight: 16 parts of angelica, 8 parts of peach kernel, 16 parts of szechuan lovage rhizome, 14 parts of salvia miltiorrhiza, 14 parts of rhodiola rosea, 8 parts of safflower, 10 parts of nutgrass galingale rhizome, 5 parts of sanchi, 10 parts of wide turmeric root-tuber, 14 parts of red paeony root, 10 parts of white paeony root, 5 parts of sandalwood, 16 parts of Chinese yam, 11 parts of prepared rehmannia root, 14 parts of polyporus umbellatus, 14 parts of tuckahoe, 16 parts of raw coix seed, 16 parts of fried coix seed, 14 parts of raw astragalus root, 14 parts of roasted astragalus root, 16 parts of heterophylly falsestarwort root and 7 parts of liquorice, crushing, adding a proper amount of water, and decocting by a conventional method.
Example 14 preparation of decoction of the Chinese medicinal composition of the present invention (fourteen)
Weighing the following raw material medicines in parts by weight: 15 parts of angelica, 9 parts of peach kernel, 15 parts of ligusticum wallichii, 15 parts of salvia miltiorrhiza, 12 parts of rhodiola rosea, 9 parts of safflower, 9 parts of rhizoma cyperi, 6 parts of pseudo-ginseng, 9 parts of radix curcumae, 12 parts of radix paeoniae rubra, 12 parts of radix paeoniae alba, 5 parts of sandalwood, 15 parts of Chinese yam, 10 parts of radix rehmanniae preparata, 15 parts of polyporus umbellatus, 15 parts of poria cocos, 15 parts of raw semen coicis, 15 parts of fried semen coicis, 15 parts of raw radix astragali, 15 parts of radix astragali preparata, 15 parts of radix pseudostellariae and 6 parts of liquorice, crushing, adding a proper amount of water, and decocting by a conventional method.
Example 15 preparation of tablets/capsules of the Chinese medicinal composition of the present invention
Weighing the raw materials according to the weight part ratio of any one of embodiments 1-14, adding 10 times and 8 times of water into each raw material respectively, decocting twice for 2 hours each time, filtering respectively, combining filtrates, concentrating to a relative density of 1.20 (80-85 ℃), cooling, adding 3 times of ethanol, stirring, standing, filtering supernatant, steaming the filtrate without alcohol smell, standing, concentrating the supernatant under reduced pressure to obtain extract, drying and crushing the extract to prepare granules, adding pharmaceutical excipients, and pressing into tablets or filling capsules.
Example 16 preparation of granules of the Chinese medicinal composition of the present invention
Weighing the raw materials according to the weight part ratio of any one of embodiments 1 to 14, adding 10 times and 8 times of water into each raw material respectively, decocting twice for 2 hours each time, filtering respectively, combining filtrates, concentrating to a relative density of 1.20 (80-85 ℃), cooling, adding 3 times of ethanol, stirring, standing, filtering supernatant, steaming the filtrate without alcohol smell, standing, concentrating the supernatant under reduced pressure to obtain extract, drying and crushing the extract to prepare granules.
EXAMPLE 17 preparation of a combination of the Chinese medicinal compositions of the present invention
Weighing the raw materials according to the weight part ratio of any one of embodiments 1 to 14, adding 10 times and 8 times of water into each raw material respectively, decocting twice for 2 hours each time, filtering respectively, combining filtrates, concentrating to a relative density of 1.20 (80-85 ℃), cooling, adding 3 times of ethanol, stirring, standing, filtering supernatant, steaming the filtrate without alcohol smell, standing, and concentrating the supernatant; adding appropriate pharmaceutical adjuvants (white sugar, mel, benzyl propionic acid or ethylparaben, etc.), and making into mixture.
EXAMPLE 18 preparation of pellets of the Chinese medicinal composition of the present invention
Weighing the raw materials according to the weight part ratio of any one of embodiments 1-14, crushing into fine powder, and sieving with a 80-mesh sieve for later use; weighing a certain amount of honey, heating in an evaporation pan until boiling (filtering if impurities exist), continuously refining to refined honey degree, and removing floating foam; mixing the refined honey and the medicinal powder according to the proportion of 1; placing the well-mixed dough-like soft material for a certain time; making into smooth and spherical pellets by hand, and wrapping with wax paper.
EXAMPLE 19 preparation of the powder of the Chinese medicinal composition of the present invention
Weighing the raw materials according to the weight part ratio of any one of embodiments 1-14, mixing, crushing into fine powder, sieving with a 80-mesh sieve, and packaging with wax paper.
EXAMPLE 20 preparation of the paste of the Chinese medicinal composition of the present invention
Weighing the raw materials according to the weight part ratio of any one of the embodiments 1-14, decocting the raw materials in a thick state, removing residues, taking thick juice, and adding 15 parts of yellow gelatin, 15 parts of Dong donkey-hide gelatin, 25 parts of maltose, 25 parts of white honey and 25 parts of yellow wine; or 15 parts of yellow gelatin, 15 parts of Dong donkey-hide gelatin, 25 parts of xylitol and 25 parts of yellow wine, and melting to obtain paste.
Example 21 treatment of ApoE with the Chinese medicinal composition of the present invention -/- Intervention effect of atherosclerosis in mice
1 materials and methods
1.1 materials
1.1.1 Experimental animals
Male ApoE at 6 weeks of age -/- SPF-grade, body weight (20 + -3 g) of mice and C57BL/6J mice purchased from Jiangsu Geiguangaokang biological familyTechnical limited company, animal quality certification No.: SCXK (su) 2018-0008. Animals were housed in the SPF animal house, the laboratory animal center of Shanghai university of medicine.
1.1.2 reagents
Oil red O staining kit (wuhan seiver biotechnology limited, G1016); FILIPIN staining kit (Shanghai Jimei Gene medicine science and technology Co., ltd., GMS 80059.3).
1.1.3 drugs
The invention relates to a formula for strengthening body resistance and removing blood stasis: weighing the following raw material medicines in parts by weight: 15 parts of angelica, 9 parts of peach kernel, 15 parts of szechuan lovage rhizome, 15 parts of salvia miltiorrhiza, 12 parts of rhodiola rosea, 9 parts of safflower, 9 parts of nutgrass galingale rhizome, 6 parts of pseudo-ginseng, 9 parts of wide turmeric root-tuber, 12 parts of red paeony root, 12 parts of white paeony root, 5 parts of sandalwood, 15 parts of Chinese yam, 10 parts of prepared rehmannia root, 15 parts of polyporus umbellatus, 15 parts of tuckahoe, 15 parts of raw coix seed, 15 parts of fried coix seed, 15 parts of raw astragalus root, 15 parts of roasted astragalus root, 15 parts of heterophyllus and 6 parts of liquorice, crushing the mixture, adding a proper amount of water, and decocting the mixture by a conventional method until the content of crude drugs is 4.0g/ml.
The original prescription for strengthening body resistance and removing blood stasis: weighing the following raw material medicines: 90g of mashed peach kernel, 90g of safflower, 150g of fried ligusticum wallichii, 150g of salvia miltiorrhiza, 120g of rhodiola rosea, 150g of aizoon stonecrop herb, 150g of red white paeony root, 150g of whole angelica, 90g of wide radix curcumae, 150g of codonopsis pilosula, 150g of raw and cooked coix seed, 150g of common yam rhizome, 150g of hoelen, 150g of raw and roasted astragalus root and 60g of liquorice, crushing, adding proper amount of water, and decocting by a conventional method until the content of crude drugs is 4.0g/ml.
Atorvastatin tablets: product of pfeiy pharmaceutical limited, DT1537.
1.2 methods
1.2.1 grouping and administration
Male ApoE at 6 weeks of age -/- The mice are fed adaptively for 8 weeks and are randomly divided into a model group, a body resistance strengthening and blood stasis removing formula, an original body resistance strengthening and blood stasis removing formula and a statin group, wherein 30 mice are fed with high-fat feed (conventional basal feed of the mice +21% fat +0.15% cholesterol). Another 30C 57BL/6/J mice were basal diet fed as normal control group. The invention relates to a body resistance strengthening and blood stasis removing formula, which is prepared from 3.525 g/kg of crude drugs -1 ·d -1 Gavage, the atorvastatin group gives 2.055 mg-kg of atorvastatin water solution -1 ·d -1 And (4) performing intragastric administration, namely performing intragastric administration on the normal group and the model group by using distilled water with the same volume, and performing intragastric administration 1 time a day. Intervention 12 weeks.
1.2.2 Observation of aortic pathomorphology
HE staining: the aorta was taken along with the heart, fixed in 10% formalin for HE staining, images were taken under light microscopy, and aortic sinus plaque area/total luminal area was analyzed using Image-Pro Plus software.
Dyeing with oil red O: the aorta was taken along with the heart, fixed in 10% formalin for oil red O staining, images were collected and the aortic sinus red stained lipid area/total luminal area was analyzed using Image-Pro Plus software.
FILIPIN staining: the aorta was taken together with the heart, fixed in 10% formalin, images were taken with a fluorescence microscope operating according to the instructions of the FILIPIN staining kit, and the area of the aortic sinus positive region/total area of the lumen was analyzed with Image J software.
1.2.3 statistical methods
SPSS 20.0 statistical software was used for data analysis, experimental data, and
the differences between the mean values of the groups were examined by one-way analysis of variance, and the LSD method or Dunnett T3 method was used for pairwise comparison. The difference is statistically significant when P is less than 0.05.
2 results of
2.1 comparison of aortic sinus plaque area/total luminal area in groups of mice
The ratio of aortic sinus plaque area/total lumen area of each group of mice is counted, and the result shows that compared with a normal group, the ratio of the plaque area/total lumen area of the mice in a model group is obviously larger than that in the normal group, and each administration group is obviously reduced compared with the model group, wherein the ratio of the aortic sinus plaque area/total lumen area of the mice in a square group for strengthening the body resistance and removing blood stasis is obviously smaller than that in a statin group. See table 1.
TABLE 1 comparison of aortic sinus plaque area/Total luminal area for each group: (
％)
P < 0.01 compared to normal group; compared with the model group, # P < 0.05, # P < 0.01; compared with statin group, Δ P is less than 0.05, and Δ P is less than 0.01.
2.2 comparison of aortic sinus lipid accumulation in groups of mice
The ratio of red-stained lipid area/total area of lumen of aortic sinus of each group of mice after being stained with oil red O is counted, and the result shows that compared with the normal group, the ratio of red-stained lipid area/total area of lumen of aortic sinus of the mice in the model group is obviously larger than that of the normal group, and each administration group is obviously reduced compared with the model group, wherein the ratio of red-stained lipid area/total area of lumen of aortic sinus of the mice in the square group for strengthening body resistance and removing blood stasis is obviously smaller than that of statin group. See table 2.
TABLE 2 comparison of red-stained lipid area of aortic sinus/Total luminal area of aortic sinus (A)
％)
P < 0.01 compared to normal group; compared with the model group, # # P is less than 0.01; compared with statin group, Δ P is < 0.01.
2.3 comparison of aortic sinus FC staining of groups of mice
The ratio of the area of the positive region of the aortic sinus to the total area of the lumen of the aortic sinus of each group of mice after FILIPIN staining is counted, and the result shows that compared with the normal group, the ratio of the area of the positive region of the aortic sinus of the model group to the total area of the lumen of the aortic sinus of the mice is obviously greater than that of the normal group, and compared with the model group, each administration group is obviously reduced, wherein the ratio of the area of the positive region of the aortic sinus of the mice in the strengthening and stasis removing square group to the total area of the lumen of the aortic sinus of the mice in the strengthening and stasis removing square group is obviously lower than that of the statin group. See table 3.
TABLE 3 aortic sinuses in groups FC area of positive staining region/total area of lumen: (
％)
P < 0.01 compared to normal group; compared with the model group, # P < 0.05, # P < 0.01; compared with statin group, Δ P is < 0.01.
3 conclusion
(1) The formula for strengthening body resistance and removing blood stasis and the original formula for strengthening body resistance and removing blood stasis can effectively intervene in atherosclerosis and reduce plaque formation, lipid accumulation and free cholesterol formation.
(2) The intervention effect of the prescription for strengthening the body resistance and removing the stasis on atherosclerosis is better than that of the original prescription for strengthening the body resistance and removing the stasis and atorvastatin tablets.
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and additions can be made without departing from the method of the present invention, and these modifications and additions should also be regarded as the protection scope of the present invention.
Claims (8)
1. The traditional Chinese medicine composition for treating atherosclerosis is characterized by being prepared from the following raw material medicines in parts by weight: 14-16 parts of angelica sinensis, 8-12 parts of peach kernel, 14-16 parts of ligusticum wallichii, 14-16 parts of salvia miltiorrhiza, 10-14 parts of rhodiola rosea, 8-10 parts of safflower, 8-10 parts of rhizoma cyperi, 5-7 parts of pseudo-ginseng, 8-10 parts of radix curcumae, 10-14 parts of radix paeoniae rubra, 10-14 parts of radix paeoniae alba, 5-6 parts of sandalwood, 14-16 parts of Chinese yam, 9-11 parts of prepared rhizome of rehmannia, 14-16 parts of polyporus umbellatus, 14-16 parts of poria cocos, 14-16 parts of raw semen coicis, 14-16 parts of fried semen coicis, 14-16 parts of raw astragalus membranaceus, 14-16 parts of roasted astragalus membranaceus, 14-16 parts of radix pseudostellariae and 5-7 parts of liquorice.
2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 15 parts of angelica, 9 parts of peach kernel, 15 parts of ligusticum wallichii, 15 parts of salvia miltiorrhiza, 12 parts of rhodiola rosea, 9 parts of safflower, 9 parts of rhizoma cyperi, 6 parts of pseudo-ginseng, 9 parts of radix curcumae, 12 parts of radix paeoniae rubra, 12 parts of radix paeoniae alba, 5 parts of sandalwood, 15 parts of Chinese yam, 10 parts of radix rehmanniae preparata, 15 parts of polyporus umbellatus, 15 parts of poria cocos, 15 parts of raw semen coicis, 15 parts of fried semen coicis, 15 parts of raw astragalus membranaceus, 15 parts of radix astragali preparata, 15 parts of radix pseudostellariae and 6 parts of liquorice.
3. The Chinese medicinal composition of claim 1, wherein the Chinese medicinal composition further comprises a pharmaceutically conventional carrier.
4. The composition of claim 3, wherein the pharmaceutically acceptable carrier comprises an emulsifier, a filler, a binder, a humectant, a disintegrant, an absorption enhancer, a flavoring agent, a coloring agent, and a solubilizing agent.
5. The traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition is in the form of decoction, pill, tablet, mixture, capsule, granule, powder, paste or wine.
6. The traditional Chinese medicine composition of claim 5, wherein the traditional Chinese medicine composition is in the form of paste, and further comprises 10-20 parts of yellow gelatin, 10-20 parts of donkey-hide gelatin, 20-30 parts of maltose, 20-30 parts of white honey and 20-30 parts of yellow wine; or further comprises 10-20 parts of yellow gelatin, 10-20 parts of donkey-hide gelatin, 20-30 parts of xylitol and 20-30 parts of yellow wine.
7. Use of a Chinese medicinal composition according to any one of claims 1 to 6 in the manufacture of a medicament for the treatment of atherosclerosis.
8. The use of claim 7, wherein the atherosclerosis is carotid, lower limb, and/or coronary atherosclerosis.
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