CN104147202B - Benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement and preparation thereof - Google Patents
Benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement and preparation thereof Download PDFInfo
- Publication number
- CN104147202B CN104147202B CN201410429420.1A CN201410429420A CN104147202B CN 104147202 B CN104147202 B CN 104147202B CN 201410429420 A CN201410429420 A CN 201410429420A CN 104147202 B CN104147202 B CN 104147202B
- Authority
- CN
- China
- Prior art keywords
- compositions
- benefiting
- microcirculatory
- nourishing blood
- improvement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
The invention discloses a kind of benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement and preparation thereof, comprise following bulk drugs through processing be prepared from: Fructus Anisi Stellati, walnut shell, willow mulberry, or Fructus Anisi Stellati, walnut shell, Flos Salicis Babylonicae.The invention provides a kind of non-stimulated, have no side effect, degree of safety is high, do not recur, can effectively benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, and the preparation obtained by said composition, preparation for treating cycle short, effective, instant effect, not recur.Compositions provided by the invention and preparation thereof, can effectively benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, improve microcirculation, cure rate and effective percentage higher, cure rate reaches 93.9%, effective percentage 100%.
Description
Technical field
The invention belongs to field of medicaments, particularly a kind of prepare with raw material of Chinese medicine benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement and preparation thereof.
Technical background
Women, due to physiological reason, can cause anemia because of a variety of causes in different class.And anemia is concerning women, not only affects healthy, can affect again face and the skin of women, cause skin dark and gloomy, coarse.In addition, because rhythm of life is accelerated, the life stress of present people and living habit drastically influence the healthy of people, if carry out toxin expelling to health not in time, will certainly bury healthy hidden danger.Chinese patent CN103961666A discloses a kind of compositions of benefiting qi and nourishing blood, but it is only for women, and inapplicable to male and child, in addition, raw material of Chinese medicine medicine is more, and whether compatibility unknowable between each raw material, preparation method is complicated.
Summary of the invention
The object of this invention is to provide one can effectively benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, improve microcirculation, effective, instant effect, have no side effect, be beneficial to absorption of human body, the benefiting qi and nourishing blood that Chinese medicine ingredients bioavailability is high, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement.
Benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, comprise following bulk drugs and be prepared from through processing:
Fructus Anisi Stellati, walnut shell, willow mulberry; Or,
Fructus Anisi Stellati, walnut shell, Flos Salicis Babylonicae.
Walnut shell comprises the walnut shell of all walnuts such as the walnut shell of common walnut and the walnut shell of Chinese walnut tree; Willow mulberry or Flos Salicis Babylonicae comprise common willow, Cortex Salicis Cheilophilae, Cacumen Tamaricis, willow mulberry of all willow trees or Flos Salicis Babylonicae.
Benefiting qi and nourishing blood provided by the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement are made up of raw material of Chinese medicine medicine, said composition can effectively benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, improve microcirculation, no dependence, have no side effect; Also there is Yin Yang balancing simultaneously, improve microcirculatory effect.
Benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, the ingredient that can also add other carries out compatibility.
Preferably, benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, the crude drug comprising following weight portion is prepared from through processing:
Fructus Anisi Stellati 0.5-5 walnut shell 0.5-5 willow mulberry 0.5-5; Or,
Fructus Anisi Stellati 0.5-5 walnut shell 0.5-5 Flos Salicis Babylonicae 0.5-5.
Further preferably, benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, the crude drug comprising following weight portion is prepared from through processing:
Fructus Anisi Stellati 1.5 walnut shell 1.5 willow mulberry 1; Or,
Fructus Anisi Stellati 1.5 walnut shell 1.5 Flos Salicis Babylonicae 1
This benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, can effectively benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, improve microcirculation, instant effect, no dependence, to have no side effect; Also there is Yin Yang balancing simultaneously, improve microcirculatory effect.
The preparation obtained by benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement and adjuvant, preparation is oral formulations, and oral formulations comprises tablet, capsule, drop pill or powder; The ratio of weight and number of compositions and adjuvant is 1:0.5-3.
The preparation obtained by benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement and adjuvant is oral formulations, oral formulations is tablet, and adjuvant comprises propylene carbonate that parts by weight are 10-28 and parts by weight are the Furcellaran of 5-10.
The synergism of propylene carbonate and Furcellaran, be conducive to the dissolution improving active component in the stability of tablet and tablet, improve the bioavailability of active component in tablet further, promote that human body is to the absorption of effective ingredient, increase the result of use of medicine, effective, instant effect; Furcellaran also plays the effect of binding agent simultaneously, is conducive to the molding of tablet and stablizes.
Further, adjuvant also comprises polacrilin potassium that parts by weight are 3-8 and parts by weight are the Oleum Ricini of 5-10.
The synergism of polacrilin potassium and Oleum Ricini, can promote the disintegrate of tablet; Oleum Ricini also plays the effect of lubricant simultaneously, is beneficial to tabletting, makes tablet surface more smooth.
Oral formulations of the present invention is non-stimulated to human body intestinal canal stomach function regulating, has no side effect, and is beneficial to absorption.
The preparation method of benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, comprises the steps:
Take each raw material of recipe quantity, dry also porphyrize respectively and obtain fine powder, by each fine powder mix homogeneously, obtain benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement.
The preparation method of benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, comprises the steps:
A) take the Fructus Anisi Stellati of recipe quantity, walnut shell two taste raw material, decoct with water three times, amount of water is 10 times of described two taste Chinese medicine gross weights for the first time, decocts 3h; Second time amount of water is 7 times of this two tastes Chinese medicine gross weight, decocts 2h; Amount of water is 3 times of this two tastes Chinese medicine gross weight for the third time, decocts 1h; Merge decoction liquor, filter, filtrate is concentrated into the extractum that relative density is 1.20-1.25, and the ethanol adding 95% carries out precipitate with ethanol, filters, and filtrate concentrates, spraying dry at 40 DEG C, obtained fine powder 1;
B) take willow mulberry or the Flos Salicis Babylonicae of recipe quantity, add alcohol reflux three times, add the ethanol of 10 times amount 90% for the first time, reflux, extract, 5h; Second time adds the ethanol of 7 times amount 90%, reflux, extract, 3h; Add the ethanol of 4 times amount 90% for the third time, reflux, extract, 1h; Merge backflow, filter, filtrate concentrates, spraying dry at 40 DEG C, obtained fine powder 2;
C) by fine powder 1 and fine powder 2 mix homogeneously, benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement is obtained.
The preparation method of benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory preparation of improvement, comprises the steps:
A) compositions is prepared;
B) Furcellaran of 3/4 recipe quantity and the propylene carbonate of recipe quantity are placed in mortar, slowly add a) the obtained compositions of step under grinding, continue grinding 1h, rotating speed is 250rmp, takes out, and crosses 120 mesh sieves, obtained solid dispersion;
C) by the Furcellaran of 1/4 recipe quantity, step b) obtained solid dispersion mix homogeneously, obtain mixed powder;
D) by step c) obtained mixed powder granulates, and carries out granulate, tabletting, obtained tablet.
The preparation method of benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory preparation of improvement, comprises the steps:
A) compositions is prepared;
B) Furcellaran of 3/4 recipe quantity and the propylene carbonate of recipe quantity are placed in mortar, slowly add a) the obtained compositions of step under grinding, continue grinding 1h, rotating speed is 250rmp, takes out, and crosses 120 mesh sieves, obtained solid dispersion;
C) by the Furcellaran of 1/4 recipe quantity, step b) obtained solid dispersion, the polacrilin potassium of recipe quantity, the Oleum Ricini mix homogeneously of 1/2 recipe quantity, obtain mixed powder;
D) by step c) obtained mixed powder granulates, and carries out granulate, adds the Oleum Ricini of 1/2 recipe quantity, mix homogeneously, tabletting, obtained tablet.
Benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, the application in the medicine preparing benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae.
Benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, preparing Yin Yang balancing, the application improved in microcirculatory medicine.
Preparation technology provided by the present invention has used modern Chinese medicine extractive technique, can reach and improve the yield of active component and the object of purity; Achieve again avirulence and the radical-ability of compositions and preparation, it is low, simple to operate that this preparation technology achieves cost simultaneously, is applicable to suitability for industrialized production; Obtained tablet, easy to use, effective, instant effect.
In the present invention, the source of primary raw material used is as follows:
Fructus Anisi Stellati (Illiciumverum): the dry mature fruit of Magnoliacea plant Fructus Anisi Stellati IlliciumverumHook.f..Autumn, season in winter two fruit pluck by during green flavescence, to put in boiling water dry after slightly scalding or convection drying.Warm in nature, acrid in the mouth, returns liver,kidney,spleen, stomach warp.
Walnut shell: the dry endocarp of Juglandaceae walnut Semen Juglandis.
Willow mulberry: the fruit of Salicaceae sallow willow.
Flos Salicis Babylonicae: the flower of Salicaceae sallow willow.
Beneficial effect of the present invention is:
(1) adopt raw material to be the raw material of Chinese medicine that degree of safety is high, the benefiting qi and nourishing blood of preparation, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement be non-stimulated, have no side effect, degree of safety is high, instant effect; Can effectively benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, improve microcirculation, no dependence, have no side effect; Also there is Yin Yang balancing simultaneously, improve microcirculatory effect; Cure rate and effective percentage higher, cure rate 93.9%, effective percentage 100%.
(2) benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory tablet of improvement, easy to use, effective, instant effect.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1 compositions
A kind of benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, said composition comprises following crude drug and is prepared from through processing:
Fructus Anisi Stellati, walnut shell, willow mulberry
Preparation method:
A) take the Fructus Anisi Stellati of recipe quantity, walnut shell two taste raw material, decoct with water three times, amount of water is 10 times of described two taste Chinese medicine gross weights for the first time, decocts 3h; Second time amount of water is 7 times of this two tastes Chinese medicine gross weight, decocts 2h; Amount of water is 3 times of this two tastes Chinese medicine gross weight for the third time, decocts 1h; Merge decoction liquor, filter, filtrate is concentrated into the extractum that relative density is 1.20-1.25, and the ethanol adding 95% carries out precipitate with ethanol, filters, and filtrate concentrates, spraying dry at 40 DEG C, obtained fine powder 1;
B) take willow mulberry of recipe quantity, add alcohol reflux three times, add the ethanol of 10 times amount 90% for the first time, reflux, extract, 5h; Second time adds the ethanol of 7 times amount 90%, reflux, extract, 3h; Add the ethanol of 4 times amount 90% for the third time, reflux, extract, 1h; Merge backflow, filter, filtrate concentrates, spraying dry at 40 DEG C, obtained fine powder 2;
C) by fine powder 1 and fine powder 2 mix homogeneously, benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement is obtained.
Embodiment 2 compositions
A kind of benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, said composition comprises following crude drug and is prepared from through processing:
Fructus Anisi Stellati, walnut shell, Flos Salicis Babylonicae;
Preparation method:
A) take the Fructus Anisi Stellati of recipe quantity, walnut shell two taste raw material, decoct with water three times, amount of water is 10 times of described two taste Chinese medicine gross weights for the first time, decocts 3h; Second time amount of water is 7 times of this two tastes Chinese medicine gross weight, decocts 2h; Amount of water is 3 times of this two tastes Chinese medicine gross weight for the third time, decocts 1h; Merge decoction liquor, filter, filtrate is concentrated into the extractum that relative density is 1.20-1.25, and the ethanol adding 95% carries out precipitate with ethanol, filters, and filtrate concentrates, spraying dry at 40 DEG C, obtained fine powder 1;
B) take the Flos Salicis Babylonicae of recipe quantity, add alcohol reflux three times, add the ethanol of 10 times amount 90% for the first time, reflux, extract, 5h; Second time adds the ethanol of 7 times amount 90%, reflux, extract, 3h; Add the ethanol of 4 times amount 90% for the third time, reflux, extract, 1h; Merge backflow, filter, filtrate concentrates, spraying dry at 40 DEG C, obtained fine powder 2;
C) by fine powder 1 and fine powder 2 mix homogeneously, benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement is obtained.
Embodiment 3 compositions
A kind of benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, the crude drug that said composition comprises following weight portion is prepared from through processing:
Fructus Anisi Stellati 0.5 walnut shell 0.5 willow mulberry 5;
Preparation method: obtain compositions according to the preparation method of embodiment 1.
Embodiment 4 compositions
A kind of benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, the crude drug that said composition comprises following weight portion is prepared from through processing:
Fructus Anisi Stellati 5 walnut shell 5 willow mulberry 0.5;
Preparation method: obtain compositions according to the preparation method of embodiment 1.
Embodiment 5 compositions
A kind of benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, the crude drug that said composition comprises following weight portion is prepared from through processing:
Fructus Anisi Stellati 1.5 walnut shell 1.5 willow mulberry 1;
Preparation method: obtain compositions according to the preparation method of embodiment 1.
Embodiment 6 compositions
A kind of benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, the crude drug that said composition comprises following weight portion is prepared from through processing:
Fructus Anisi Stellati 0.5 walnut shell 5 Flos Salicis Babylonicae 5;
Preparation method: obtain compositions according to the preparation method of embodiment 2.
Embodiment 7 compositions
A kind of benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, the crude drug that said composition comprises following weight portion is prepared from through processing:
Fructus Anisi Stellati 5 walnut shell 0.5 Flos Salicis Babylonicae 0.5;
Preparation method: obtain compositions according to the preparation method of embodiment 2.
Embodiment 8 compositions
A kind of benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, the crude drug that said composition comprises following weight portion is prepared from through processing:
Fructus Anisi Stellati 1.5 walnut shell 1.5 Flos Salicis Babylonicae 1;
Preparation method: obtain compositions according to the preparation method of embodiment 2.
Embodiment 9 tablet
Prescription:
Compositions 20g prepared by embodiment 5
Adjuvant: propylene carbonate 45g
Furcellaran 15g
Preparation method:
A) compositions is prepared;
B) Furcellaran of 3/4 recipe quantity and the propylene carbonate of recipe quantity are placed in mortar, slowly add a) the obtained compositions of step under grinding, continue grinding 1h, rotating speed is 250rmp, takes out, and crosses 120 mesh sieves, obtained solid dispersion;
C) by the Furcellaran of 1/4 recipe quantity, step b) obtained solid dispersion mix homogeneously, obtain mixed powder;
D) by step c) obtained mixed powder granulates, and carries out granulate, tabletting, obtained tablet, every sheet 0.5g.
Embodiment 10 tablet
Prescription:
Compositions 20g prepared by embodiment 5
Adjuvant: propylene carbonate 7g
Furcellaran 3g
Preparation method: obtain compositions according to the preparation method of embodiment 9.
Embodiment 11 tablet
Prescription:
Compositions 20g prepared by embodiment 5
Preparation method:
A) compositions is prepared;
B) Furcellaran of 3/4 recipe quantity and the propylene carbonate of recipe quantity are placed in mortar, slowly add a) the obtained compositions of step under grinding, continue grinding 1h, rotating speed is 250rmp, takes out, and crosses 120 mesh sieves, obtained solid dispersion;
C) by the Furcellaran of 1/4 recipe quantity, step b) obtained solid dispersion, the polacrilin potassium of recipe quantity, the Oleum Ricini mix homogeneously of 1/2 recipe quantity, obtain mixed powder;
D) by step c) obtained mixed powder granulates, and carries out granulate, adds the Oleum Ricini of 1/2 recipe quantity, mix homogeneously, tabletting, obtained tablet, every sheet 0.5g.
Embodiment 12 tablet
Prescription:
Compositions 20g prepared by embodiment 8
Preparation method: obtain tablet according to the preparation method of embodiment 11, every sheet 0.5g.
Comparative examples 1 tablet
Prescription:
Compositions 20g prepared by embodiment 4
Adjuvant: propylene carbonate 10g
Polacrilin potassium 3g
Oleum Ricini 5g
Preparation method:
A) compositions is prepared;
B) propylene carbonate of recipe quantity is placed in mortar, slowly adds a) the obtained compositions of step under grinding, continue grinding 1h, rotating speed is 250rmp, takes out, and crosses 120 mesh sieves, obtained solid dispersion;
C) by step b) obtained solid dispersion, the polacrilin potassium of recipe quantity, the Oleum Ricini mix homogeneously of 1/2 recipe quantity, obtain mixed powder;
D) by step c) obtained mixed powder granulates, and carries out granulate, adds the Oleum Ricini of 1/2 recipe quantity, mix homogeneously, tabletting, obtained tablet, every sheet 0.5g.
Comparative examples 2 tablet
Prescription:
Compositions 20g prepared by embodiment 7
Preparation method: obtain tablet according to the preparation method of embodiment 13, every sheet 0.5g.
For this situation is described, now further illustrate effect of the present invention by test example as follows:
Test example 1 stability test
1. accelerated test
The tablet of Example 11, be divided into 3 batches, be numbered sample 1, sample 2 and sample 3 respectively, at temperature 40 DEG C ± 2 DEG C, relative humidity is place 6 months under the condition of 75% ± 5%, samples respectively once 1 month, 2 months, 3 months, 6 the end of month at duration of test, by the regulation in Chinese Pharmacopoeia, detect the character of tablet, the content (labelled amount %) of anisaldehyde, found that, indices has no significant change;
The tablet of Example 12, tests under similarity condition, comes to the same thing;
Getting the tablet of comparative examples 1,2, test under similarity condition, all there is significant change in the character of tablet, the content (labelled amount %) of anisaldehyde.
2. long term test
The tablet of Example 11, be divided into 3 batches, be numbered sample 1, sample 2 and sample 3 respectively, at temperature 25 DEG C ± 2 DEG C, relative humidity is place 24 months under the condition of 60% ± 10%, samples respectively once 0 month, 3 months, 6 months, 9 months, 12 months, 18 months, 24 the end of month at duration of test, by the regulation in Chinese Pharmacopoeia, detect the character of tablet, the content (labelled amount %) of anisaldehyde, found that, indices has no significant change;
The tablet of Example 12, tests under similarity condition, comes to the same thing;
Getting the tablet of comparative examples 1,2, test under similarity condition, all there is significant change in the character of tablet, the content (labelled amount %) of anisaldehyde.
From stability test, the tablet of comparative examples 1,2 is stablized not as the tablet of embodiment 11,12, and this illustrates, Furcellaran can improve the stability of tablet with propylene carbonate synergism; In the amount ranges of the present invention's restriction, the good stability of tablet.
Test example 2 clinical trial
1. benefiting qi and nourishing blood
1. case selection:
Treatment group 1:32 example, age 30-50 year, average 38 years old, the course of disease 2-7 week;
Treatment group 2:32 example, age 30-50 year, average 38 years old, the course of disease 2-7 week;
Treatment group 3:32 example, age 30-50 year, average 38 years old, the course of disease 2-7 week;
Matched group: 32 example, age 30-50 year, average 38 years old, the course of disease 2-7 week.
2. administering mode:
Treatment group 1: use the benefiting qi and nourishing blood of the embodiment of the present invention 5, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, every day 2 times, warm water is taken after mixing it with water after meal, and a course for the treatment of is two weeks, uses three courses for the treatment of continuously;
Treatment group 2: use the benefiting qi and nourishing blood of the embodiment of the present invention 8, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, every day 2 times, warm water is taken after mixing it with water after meal, and a course for the treatment of is two weeks, uses three courses for the treatment of continuously;
Matched group: oral FUKANGBAO KOUFUYE (composition: Radix Rehmanniae Preparata, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Folium Artemisiae Argyi, Radix Angelicae Sinensis, Radix Glycyrrhizae, Colla Corii Asini, adjuvant is brown sugar), every day 2 times, one after each meal, a course for the treatment of is two weeks, uses three courses for the treatment of continuously.
3. classical symptom: giddy, tinnitus, headache, insomnia, dreaminess, cutis laxa, microgroove, eye pouch, health are weak, easily tired.
4. diagnostic criteria:
Recovery from illness: clinical symptoms disappears completely.
Effective: clinical symptoms disappears substantially.
Effective: clinical symptom relief.
Invalid: substantially unchanged.
5. result of the test:
The comparitive study for the treatment of group and matched group the results are shown in Table 1;
The comparitive study of table 1 treatment group and matched group
From treatment group 1,2 and matched group to the comparitive study of benefiting qi and nourishing blood, treatment group and matched group compare and have diversity (P < 0.05), illustrate that benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions curative effect of improvement are significantly increased relative to matched group.
6. effect judges: benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, and effective percentage 100%, cure rate 93.8%, effectively can treat benefiting qi and nourishing blood, effective percentage and cure rate are all higher, good effect, the cycle is short, and curative effect is significantly better than matched group.
2. toxin expelling Fructus Alpiniae Oxyphyllae
1. case selection:
Treatment group 1:33 example, age 28-52 year, average 35 years old, the course of disease 2-7 week;
Treatment group 2:33 example, age 28-52 year, average 35 years old, the course of disease 2-7 week;
Matched group: 33 example, age 28-52 year, average 35 years old, the course of disease 2-7 week.
2. administering mode:
Treatment group 1: use the benefiting qi and nourishing blood of the embodiment of the present invention 5, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, every day 2 times, warm water is taken after mixing it with water after meal, and a course for the treatment of is two weeks, uses three courses for the treatment of continuously;
Treatment group 2: use the benefiting qi and nourishing blood of the embodiment of the present invention 8, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, every day 2 times, warm water is taken after mixing it with water after meal, and a course for the treatment of is two weeks, uses three courses for the treatment of continuously;
Matched group: oral cedar seed grows heart ball (composition: Semen Platycladi, Fructus Lycii, Rhizoma Acori Graminei, Radix Scrophulariae, Radix Glycyrrhizae (processing), Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Poria), every day 3 times, warm water is taken after mixing it with water after meal, and a course for the treatment of is two weeks, uses three courses for the treatment of continuously.
3. classical symptom: easily sick, insomnia, dreaminess, hypomnesis, absent minded.
4. diagnostic criteria:
Recovery from illness: clinical symptoms disappears completely.
Effective: clinical symptoms disappears substantially.
Effective: clinical symptom relief.
Invalid: substantially unchanged.
5. result of the test:
The comparitive study for the treatment of group and matched group the results are shown in Table 2;
The comparitive study of table 2 treatment group and matched group
From treatment group 1,2 and matched group to the comparitive study of toxin expelling Fructus Alpiniae Oxyphyllae, treatment group and matched group compare and have diversity (P < 0.05), illustrate that benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions curative effect of improvement are significantly increased relative to matched group.
6. effect judges: benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, and effective percentage 100%, cure rate 93.9% can effectively toxin expelling Fructus Alpiniae Oxyphyllaes, effective percentage and cure rate are all higher, good effect, the cycle is short, and curative effect is significantly better than matched group.
Typical apply 1:
Lee, female, 29 years old, iron deficiency anemia, dim complexion, fatiguability.With the medicine crossing multiple benefiting qi and nourishing blood, effect is all undesirable.Treatment: by using the tablet obtained by benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement the course for the treatment of, every day 2 times, warm water is taken after mixing it with water after meal, and a course for the treatment of is two weeks, uses three courses for the treatment of continuously.After treating 1 course for the treatment of, patients symptomatic alleviates.Continue 1 course for the treatment of of use, symptom disappears completely.Continue 1 course for the treatment of of use, consolidated.Follow-up investigation finds after 1 year without recurrence.
Typical apply 2:
Zeng, female, 47 years old, anemia, emaciated physique, yellowish complexion dried and withered hairs.With the medicine crossing multiple benefiting qi and nourishing blood, effect is all undesirable.Treatment: use by benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement or tablet by the course for the treatment of, every day 2 times, warm water is taken after mixing it with water after meal, and a course for the treatment of is two weeks, uses three courses for the treatment of continuously.After treating 1 course for the treatment of, patients symptomatic alleviates.Continue 1 course for the treatment of of use, symptom disappears completely.Continue 1 course for the treatment of of use, consolidated.Follow-up investigation finds after 1 year without recurrence.
Typical apply 3:
Lee, female, 32 years old, easily sick, insomnia, dreaminess, hypomnesis, absent minded.With the medicine crossing multiple toxin expelling Fructus Alpiniae Oxyphyllae, effect is all undesirable.Treatment: by using the tablet obtained by benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement the course for the treatment of, every day 2 times, warm water is taken after mixing it with water after meal, and a course for the treatment of is two weeks, uses three courses for the treatment of continuously.After treating 1 course for the treatment of, patients symptomatic alleviates.Continue 1 course for the treatment of of use, symptom disappears completely.Continue 1 course for the treatment of of use, consolidated.Follow-up investigation finds after 1 year without recurrence.
Typical apply 4:
Liu, man, 41 years old, insomnia, dreaminess, hypomnesis.With the medicine crossing multiple toxin expelling Fructus Alpiniae Oxyphyllae, effect is all undesirable.Treatment: use by benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement or tablet by the course for the treatment of, every day 2 times, warm water is taken after mixing it with water after meal, and a course for the treatment of is two weeks, uses three courses for the treatment of continuously.After treating 1 course for the treatment of, patients symptomatic alleviates.Continue 1 course for the treatment of of use, symptom disappears completely.Continue 1 course for the treatment of of use, consolidated.Follow-up investigation finds after 1 year without recurrence.
Claims (10)
1. benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, is characterized in that, described compositions is prepared from through processing by the crude drug of following weight portion:
Fructus Anisi Stellati 0.5-5 walnut shell 0.5-5 willow mulberry 0.5-5; Or,
Fructus Anisi Stellati 0.5-5 walnut shell 0.5-5 Flos Salicis Babylonicae 0.5-5.
2. benefiting qi and nourishing blood according to claim 1, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, is characterized in that, described compositions is prepared from through processing by the crude drug of following weight portion:
Fructus Anisi Stellati 1.5 walnut shell 1.5 willow mulberry 1; Or,
Fructus Anisi Stellati 1.5 walnut shell 1.5 Flos Salicis Babylonicae 1.
3. a preparation, obtained by benefiting qi and nourishing blood according to claim 1, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement and adjuvant, it is characterized in that, described preparation is oral formulations, and the ratio of weight and number of described compositions and adjuvant is 1:0.5-3.
4. preparation according to claim 3, is characterized in that, described oral formulations is tablet, capsule, drop pill or powder.
5. preparation according to claim 4, is characterized in that, described oral formulations is tablet, and described adjuvant comprises propylene carbonate that parts by weight are 10-28 and parts by weight are the Furcellaran of 5-10.
6. preparation according to claim 5, is characterized in that, described adjuvant also comprises polacrilin potassium that parts by weight are 3-8 and parts by weight are the Oleum Ricini of 5-10.
7. a preparation method for the benefiting qi and nourishing blood described in any one of claim 1-2, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, it is characterized in that, described method comprises the steps:
Take each raw material, dry also porphyrize respectively and obtain fine powder, by each fine powder mix homogeneously, obtain benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement.
8. a preparation method for the benefiting qi and nourishing blood described in any one of claim 1-2, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, it is characterized in that, described method comprises the steps:
A) take Fructus Anisi Stellati, walnut shell two taste raw material, decoct with water three times, amount of water is 10 times of described two taste Chinese medicine gross weights for the first time, decocts 3h; Second time amount of water is 7 times of this two tastes Chinese medicine gross weight, decocts 2h; Amount of water is 3 times of this two tastes Chinese medicine gross weight for the third time, decocts 1h; Merge decoction liquor, filter, filtrate is concentrated into the extractum that relative density is 1.20-1.25, and the ethanol adding 95% carries out precipitate with ethanol, filters, and filtrate concentrates, spraying dry at 40 DEG C, obtained fine powder 1;
B) take willow mulberry or Flos Salicis Babylonicae, add alcohol reflux three times, add the ethanol of 10 times amount 90% for the first time, reflux, extract, 5h; Second time adds the ethanol of 7 times amount 90%, reflux, extract, 3h; Add the ethanol of 4 times amount 90% for the third time, reflux, extract, 1h; Merge backflow, filter, filtrate concentrates, spraying dry at 40 DEG C, obtained fine powder 2;
C) by fine powder 1 and fine powder 2 mix homogeneously, benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement is obtained.
9. a preparation method for preparation according to claim 6, is characterized in that, described method comprises the steps:
A) compositions is prepared;
B) Furcellaran of 3/4 and propylene carbonate are placed in mortar, slowly add a) the obtained compositions of step under grinding, continue grinding 1h, rotating speed is 250rmp, takes out, and crosses 120 mesh sieves, obtained solid dispersion;
C) by the Furcellaran of 1/4, step b) obtained solid dispersion, polacrilin potassium, 1/2 Oleum Ricini mix homogeneously, obtain mixed powder;
D) by step c) obtained mixed powder granulates, and carries out granulate, adds the Oleum Ricini of 1/2, mix homogeneously, tabletting, obtained tablet.
10. benefiting qi and nourishing blood according to claim 1, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement are preparing the application in benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae or Yin Yang balancing, the microcirculatory medicine of improvement.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410429420.1A CN104147202B (en) | 2014-08-28 | 2014-08-28 | Benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410429420.1A CN104147202B (en) | 2014-08-28 | 2014-08-28 | Benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement and preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104147202A CN104147202A (en) | 2014-11-19 |
| CN104147202B true CN104147202B (en) | 2016-03-30 |
Family
ID=51872966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410429420.1A Expired - Fee Related CN104147202B (en) | 2014-08-28 | 2014-08-28 | Benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement and preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104147202B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103445241A (en) * | 2013-07-26 | 2013-12-18 | 王思伟 | Kidney tonifying and vigor nourishing mutton soup and preparation method thereof |
-
2014
- 2014-08-28 CN CN201410429420.1A patent/CN104147202B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103445241A (en) * | 2013-07-26 | 2013-12-18 | 王思伟 | Kidney tonifying and vigor nourishing mutton soup and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104147202A (en) | 2014-11-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103990081B (en) | Traditional Chinese medicine composition and application thereof in preparation of medicine for treating infant jaundice | |
| CN103520572A (en) | Traditional Chinese composition used for treating atopic dermatitis as well as preparation method of composition | |
| CN101085079B (en) | Traditional Chinese medicine compound for treating diabetes and its preparation method and application | |
| CN103690784B (en) | The Chinese medicine composition for the treatment of Complicating with Hypentersion nephropathy and preparation method | |
| CN107890528B (en) | Traditional Chinese medicine composition for treating hyperuricemia and preparation method thereof | |
| CN105031218A (en) | Traditional Chinese medicine formula for treating diabetes induced by deficiency of both qi and yin as well as preparation method and application thereof | |
| CN104147202B (en) | Benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement and preparation thereof | |
| CN103341095B (en) | Clysis liquid used for chronic renal failure | |
| CN102908489B (en) | Traditional Chinese medicine composition for treating seborrheic alopecia and preparation method of same | |
| CN105687522A (en) | Pharmaceutical composition with chloasma removing function and preparation method thereof | |
| CN105031219A (en) | Traditional Chinese medicine compound preparation for treating diabetes induced by deficiency of both qi and yin as well as preparation method and application thereof | |
| CN105168581A (en) | Application of traditional Chinese medicine composition in preparation of drugs for treating diabetic nephropathies | |
| CN104436022A (en) | Hemsleya-macrosperma-containing traditional Chinese medicine composition for treating diabetes mellitus | |
| CN103961615A (en) | Traditional Chinese medicine composition for treating rhagadia manus and pedalis and preparation thereof | |
| CN104056017A (en) | Traditional Chinese medicine composition for treating rheumatism and preparation method thereof | |
| CN104524359B (en) | A kind of Chinese medicine composition, its preparation method and application | |
| CN104337898B (en) | A kind of Chinese medicine composition of the treatment gout containing Semen Pruni | |
| CN103386040A (en) | Hypoglycemic traditional Chinese medicine preparation and preparation method thereof | |
| CN114404547B (en) | Body resistance strengthening and blood stasis removing cream formula and application thereof | |
| CN103961602B (en) | The treatment Chinese medicine composition of chronic gastritis and tablet thereof and preparation method | |
| CN101284090A (en) | Herb tea, beverage, soybean milk preparation for curing wind-heat type skin pruritus | |
| CN105497783A (en) | Application of traditional Chinese medicine preparation to preparing drug for treating qi stagnation and blood stasis type chloasma | |
| CN104524009B (en) | The pharmaceutical composition and application of external curing obesity | |
| CN105250749A (en) | Traditional Chinese medicine for treating thyroid adenoma and preparation method thereof | |
| CN104352974A (en) | Ciliatenerve knotweed root-containing traditional Chinese medicine composition for treating diabetes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160330 Termination date: 20160828 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |