CN104147202A - Qi-tonifying and blood-nourishing, toxin-removing and intelligence-boosting, yin-yang-balancing and microcirculation-improving composition and preparation thereof - Google Patents
Qi-tonifying and blood-nourishing, toxin-removing and intelligence-boosting, yin-yang-balancing and microcirculation-improving composition and preparation thereof Download PDFInfo
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Abstract
The invention discloses a qi-tonifying and blood-nourishing, toxin-removing and intelligence-boosting, yin-yang-balancing and microcirculation-improving composition and a preparation thereof. The composition is prepared from following raw material medicines comprising: illicium verum, walnut shell and willow fruits, or illicium verum, walnut shell and willow flowers. The invention provides a qi-tonifying and blood-nourishing, toxin-removing and intelligence-boosting, yin-yang-balancing and microcirculation-improving composition which is free of stimulation, is free of toxic and side effects, is high in safety degree and is free of relapse, and also provides the preparation which is prepared from the composition. The preparation is short in treatment period, is good in effect, is quick in effect and is free of relapse. The composition and the preparation thereof in the invention can effectively tonify qi and nourish blood, remove toxic and boost intelligence, balance yin and yang and improve microcirculation and is high in curative rate and effective rate, wherein the curative rate can reach 93.9% and the effective rate can reach 100%.
Description
Technical field
The invention belongs to field of medicaments, particularly a kind of benefiting qi and nourishing blood of preparing with raw material of Chinese medicine, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement and preparation thereof.
Technical background
Women, due to physiological reason, can cause anemia because of a variety of causes in different classes.And anemia is concerning women, not only affect healthyly, can affect again women's face and skin, cause skin dark and gloomy, coarse.In addition, because rhythm of life is accelerated, people's life stress and living habit are having a strong impact on the healthy of people now, if not in time health is carried out to toxin expelling, will certainly bury healthy hidden danger.Chinese patent CN 103961666A discloses a kind of compositions of benefiting qi and nourishing blood, but it is only for women, and to male and child inapplicable, in addition, raw material of Chinese medicine medicine is more, and between each raw material, whether compatibility is also unknowable, and preparation method is complicated.
Summary of the invention
The object of this invention is to provide a kind of effectively benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, improve microcirculation, effective, instant effect, have no side effect, be beneficial to absorption of human body, the benefiting qi and nourishing blood that Chinese medicine ingredients bioavailability is high, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement.
Benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, comprise that following bulk drugs is prepared from through processing:
Fructus Anisi Stellati, walnut shell, willow mulberry; Or,
Fructus Anisi Stellati, walnut shell, Flos Salicis Babylonicae.
Walnut shell comprises the walnut shell of the walnut shell of common walnut and all walnuts such as walnut shell of Chinese walnut tree; Willow mulberry or Flos Salicis Babylonicae comprise willow mulberry or the Flos Salicis Babylonicae of common willow, Cortex Salicis Cheilophilae, Cacumen Tamaricis, all willow trees.
Benefiting qi and nourishing blood provided by the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement are comprised of raw material of Chinese medicine medicine, said composition effectively benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, improve microcirculation, no dependence, has no side effect; Also there is Yin Yang balancing simultaneously, improve microcirculatory effect.
Benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, can also add other ingredient to carry out compatibility.
Preferably, benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, comprise that the crude drug of following weight portion is prepared from through processing:
Fructus Anisi Stellati 0.5-5 walnut shell 0.5-5 willow mulberry 0.5-5; Or,
Fructus Anisi Stellati 0.5-5 walnut shell 0.5-5 Flos Salicis Babylonicae 0.5-5.
Further preferably, benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, comprise that the crude drug of following weight portion is prepared from through processing:
Fructus Anisi Stellati 1.5 walnut shell 1.5 willow mulberrys 1; Or,
Fructus Anisi Stellati 1.5 walnut shell 1.5 Flos Salicis Babylonicae 1
This benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, effectively benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, improve microcirculation, instant effect, no dependence, have no side effect; Also there is Yin Yang balancing simultaneously, improve microcirculatory effect.
The preparation being made by benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement and adjuvant, preparation is oral formulations, oral formulations comprises tablet, capsule, drop pill or powder; The ratio of weight and number of compositions and adjuvant is 1:0.5-3.
The preparation being made by benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement and adjuvant is oral formulations, oral formulations is tablet, and adjuvant comprises that parts by weight are the propylene carbonate of 10-28 and the Furcellaran that parts by weight are 5-10.
The synergism of propylene carbonate and Furcellaran, be conducive to improve the dissolution of active component in the stability of tablet and tablet, further improve the bioavailability of active component in tablet, promote the absorption of human body to effective ingredient, increase the result of use of medicine, effective, instant effect; Furcellaran also plays the effect of binding agent simultaneously, is conducive to the molding of tablet and stablizes.
Further, adjuvant also comprises that parts by weight are the polacrilin potassium of 3-8 and the Oleum Ricini that parts by weight are 5-10.
The synergism of polacrilin potassium and Oleum Ricini, can promote the disintegrate of tablet; Oleum Ricini also plays the effect of lubricant simultaneously, is beneficial to tabletting, makes tablet surface more smooth.
Oral formulations of the present invention is non-stimulated to human body intestinal canal stomach function regulating, has no side effect, and is beneficial to absorption.
The preparation method of benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, comprises the steps:
Take each raw material of recipe quantity, dry respectively also porphyrize and obtain fine powder, by each fine powder mix homogeneously, obtain benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement.
The preparation method of benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, comprises the steps:
A) take Fructus Anisi Stellati, the walnut shell two taste raw materials of recipe quantity, decoct with water three times, amount of water is 10 times of described two taste Chinese medicine gross weights for the first time, decocts 3h; Amount of water is 7 times of this two tastes Chinese medicine gross weight for the second time, decocts 2h; Amount of water is 3 times of this two tastes Chinese medicine gross weight for the third time, decocts 1h; Merge decoction liquor, filter, filtrate is concentrated into the extractum that relative density is 1.20-1.25, adds 95% ethanol and carries out precipitate with ethanol, filters, and filtrate is concentrated, at 40 ℃ spraying dry, make fine powder 1;
B) take willow mulberry or the Flos Salicis Babylonicae of recipe quantity, add alcohol reflux three times, add for the first time the ethanol of 10 times of amounts 90%, reflux, extract, 5h; The ethanol that adds for the second time 7 times of amounts 90%, reflux, extract, 3h; The ethanol that adds for the third time 4 times of amounts 90%, reflux, extract, 1h; Merge backflow, filter, filtrate is concentrated, and at 40 ℃, spraying is dried, and makes fine powder 2;
C), by fine powder 1 and fine powder 2 mix homogeneously, obtain benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement.
The preparation method of benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory preparation of improvement, comprises the steps:
A) prepare compositions;
B) propylene carbonate of the Furcellaran of 3/4 recipe quantity and recipe quantity is placed in to mortar, the compositions that slowly adds step a) to make under grinding, continues to grind 1h, and rotating speed is 250rmp, takes out, and crosses 120 mesh sieves, makes solid dispersion;
C) by the Furcellaran of 1/4 recipe quantity, step b) the solid dispersion mix homogeneously that makes, obtain mixed powder;
D) by step c) mixed powder that makes granulates, and carry out granulate, tabletting, makes tablet.
The preparation method of benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory preparation of improvement, comprises the steps:
A) prepare compositions;
B) propylene carbonate of the Furcellaran of 3/4 recipe quantity and recipe quantity is placed in to mortar, the compositions that slowly adds step a) to make under grinding, continues to grind 1h, and rotating speed is 250rmp, takes out, and crosses 120 mesh sieves, makes solid dispersion;
C) by the Furcellaran of 1/4 recipe quantity, step b) the Oleum Ricini mix homogeneously of the solid dispersion making, the polacrilin potassium of recipe quantity, 1/2 recipe quantity, obtain mixed powder;
D) by step c) mixed powder that makes granulates, and carry out granulate, and add the Oleum Ricini of 1/2 recipe quantity, mix homogeneously, tabletting, makes tablet.
Benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, the application in the medicine of preparing benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae.
Benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, preparing Yin Yang balancing, improving the application in microcirculatory medicine.
Preparation technology provided by the present invention has used modern Chinese medicine extractive technique, can reach and improve the yield of active component and the object of purity; Avirulence and radical-ability simultaneously that realized again compositions and preparation, it is low, simple to operate that this preparation technology has realized cost, is applicable to suitability for industrialized production; The tablet making, easy to use, effective, instant effect.
In the present invention, the source of primary raw material used is as follows:
Fructus Anisi Stellati (Illicium verum): the dry mature fruit of Magnoliacea plant Fructus Anisi Stellati Illicium verum Hook.f..Autumn, two season of winter pluck when fruit is by green flavescence, put slightly boiling hot rear dry or convection drying in boiling water.Warm in nature, acrid in the mouth, returns liver,kidney,spleen, stomach warp.
Walnut shell: the dry endocarp of Juglandaceae walnut Semen Juglandis.
Willow mulberry: the fruit of Salicaceae sallow willow.
Flos Salicis Babylonicae: the flower of Salicaceae sallow willow.
Beneficial effect of the present invention is:
(1) adopting raw material is the raw material of Chinese medicine that degree of safety is high, and the benefiting qi and nourishing blood of preparation, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement be non-stimulated, have no side effect, and degree of safety is high, instant effect; Effectively benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, improve microcirculation, no dependence, has no side effect; Also there is Yin Yang balancing simultaneously, improve microcirculatory effect; Cure rate and effective percentage are higher, cure rate 93.9%, effective percentage 100%.
(2) benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory tablet of improvement, easy to use, effective, instant effect.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1 compositions
Benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, said composition comprises that following crude drug is prepared from through processing:
Fructus Anisi Stellati, walnut shell, willow mulberry
Preparation method:
A) take Fructus Anisi Stellati, the walnut shell two taste raw materials of recipe quantity, decoct with water three times, amount of water is 10 times of described two taste Chinese medicine gross weights for the first time, decocts 3h; Amount of water is 7 times of this two tastes Chinese medicine gross weight for the second time, decocts 2h; Amount of water is 3 times of this two tastes Chinese medicine gross weight for the third time, decocts 1h; Merge decoction liquor, filter, filtrate is concentrated into the extractum that relative density is 1.20-1.25, adds 95% ethanol and carries out precipitate with ethanol, filters, and filtrate is concentrated, at 40 ℃ spraying dry, make fine powder 1;
B) take willow mulberry of recipe quantity, add alcohol reflux three times, add for the first time the ethanol of 10 times of amounts 90%, reflux, extract, 5h; The ethanol that adds for the second time 7 times of amounts 90%, reflux, extract, 3h; The ethanol that adds for the third time 4 times of amounts 90%, reflux, extract, 1h; Merge backflow, filter, filtrate is concentrated, and at 40 ℃, spraying is dried, and makes fine powder 2;
C), by fine powder 1 and fine powder 2 mix homogeneously, obtain benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement.
Embodiment 2 compositionss
Benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, said composition comprises that following crude drug is prepared from through processing:
Fructus Anisi Stellati, walnut shell, Flos Salicis Babylonicae;
Preparation method:
A) take Fructus Anisi Stellati, the walnut shell two taste raw materials of recipe quantity, decoct with water three times, amount of water is 10 times of described two taste Chinese medicine gross weights for the first time, decocts 3h; Amount of water is 7 times of this two tastes Chinese medicine gross weight for the second time, decocts 2h; Amount of water is 3 times of this two tastes Chinese medicine gross weight for the third time, decocts 1h; Merge decoction liquor, filter, filtrate is concentrated into the extractum that relative density is 1.20-1.25, adds 95% ethanol and carries out precipitate with ethanol, filters, and filtrate is concentrated, at 40 ℃ spraying dry, make fine powder 1;
B) take the Flos Salicis Babylonicae of recipe quantity, add alcohol reflux three times, add for the first time the ethanol of 10 times of amounts 90%, reflux, extract, 5h; The ethanol that adds for the second time 7 times of amounts 90%, reflux, extract, 3h; The ethanol that adds for the third time 4 times of amounts 90%, reflux, extract, 1h; Merge backflow, filter, filtrate is concentrated, and at 40 ℃, spraying is dried, and makes fine powder 2;
C), by fine powder 1 and fine powder 2 mix homogeneously, obtain benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement.
Embodiment 3 compositionss
Benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, said composition comprises that the crude drug of following weight portion is prepared from through processing:
Fructus Anisi Stellati 0.5 walnut shell 0.5 willow mulberry 5;
Preparation method: the preparation method according to embodiment 1 makes compositions.
Embodiment 4 compositionss
Benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, said composition comprises that the crude drug of following weight portion is prepared from through processing:
Fructus Anisi Stellati 5 walnut shell 5 willow mulberrys 0.5;
Preparation method: the preparation method according to embodiment 1 makes compositions.
Embodiment 5 compositionss
Benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, said composition comprises that the crude drug of following weight portion is prepared from through processing:
Fructus Anisi Stellati 1.5 walnut shell 1.5 willow mulberrys 1;
Preparation method: the preparation method according to embodiment 1 makes compositions.
Embodiment 6 compositionss
Benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, said composition comprises that the crude drug of following weight portion is prepared from through processing:
Fructus Anisi Stellati 0.5 walnut shell 5 Flos Salicis Babylonicae 5;
Preparation method: the preparation method according to embodiment 2 makes compositions.
Embodiment 7 compositionss
Benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, said composition comprises that the crude drug of following weight portion is prepared from through processing:
Fructus Anisi Stellati 5 walnut shell 0.5 Flos Salicis Babylonicae 0.5;
Preparation method: the preparation method according to embodiment 2 makes compositions.
Embodiment 8 compositionss
Benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, said composition comprises that the crude drug of following weight portion is prepared from through processing:
Fructus Anisi Stellati 1.5 walnut shell 1.5 Flos Salicis Babylonicae 1;
Preparation method: the preparation method according to embodiment 2 makes compositions.
Embodiment 9 tablets
Prescription:
The compositions 20g of embodiment 5 preparations
Adjuvant: propylene carbonate 45g
Furcellaran 15g
Preparation method:
A) prepare compositions;
B) propylene carbonate of the Furcellaran of 3/4 recipe quantity and recipe quantity is placed in to mortar, the compositions that slowly adds step a) to make under grinding, continues to grind 1h, and rotating speed is 250rmp, takes out, and crosses 120 mesh sieves, makes solid dispersion;
C) by the Furcellaran of 1/4 recipe quantity, step b) the solid dispersion mix homogeneously that makes, obtain mixed powder;
D) by step c) mixed powder that makes granulates, and carry out granulate, tabletting, makes tablet, every 0.5g.
Embodiment 10 tablets
Prescription:
The compositions 20g of embodiment 5 preparations
Adjuvant: propylene carbonate 7g
Furcellaran 3g
Preparation method: the preparation method according to embodiment 9 makes compositions.
Embodiment 11 tablets
Prescription:
The compositions 20g of embodiment 5 preparations
Preparation method:
A) prepare compositions;
B) propylene carbonate of the Furcellaran of 3/4 recipe quantity and recipe quantity is placed in to mortar, the compositions that slowly adds step a) to make under grinding, continues to grind 1h, and rotating speed is 250rmp, takes out, and crosses 120 mesh sieves, makes solid dispersion;
C) by the Furcellaran of 1/4 recipe quantity, step b) the Oleum Ricini mix homogeneously of the solid dispersion making, the polacrilin potassium of recipe quantity, 1/2 recipe quantity, obtain mixed powder;
D) by step c) mixed powder that makes granulates, and carry out granulate, and add the Oleum Ricini of 1/2 recipe quantity, mix homogeneously, tabletting, makes tablet, every 0.5g.
Embodiment 12 tablets
Prescription:
The compositions 20g of embodiment 8 preparations
Preparation method: the preparation method according to embodiment 11 makes tablet, every 0.5g.
Control Example 1 tablet
Prescription:
The compositions 20g of embodiment 4 preparations
Adjuvant: propylene carbonate 10g
Polacrilin potassium 3g
Oleum Ricini 5g
Preparation method:
A) prepare compositions;
B) propylene carbonate of recipe quantity is placed in to mortar, the compositions that slowly adds step a) to make under grinding, continues to grind 1h, and rotating speed is 250rmp, takes out, and crosses 120 mesh sieves, makes solid dispersion;
C) by step b) the Oleum Ricini mix homogeneously of the solid dispersion making, the polacrilin potassium of recipe quantity, 1/2 recipe quantity, obtain mixed powder;
D) by step c) mixed powder that makes granulates, and carry out granulate, and add the Oleum Ricini of 1/2 recipe quantity, mix homogeneously, tabletting, makes tablet, every 0.5g.
Control Example 2 tablets
Prescription:
The compositions 20g of embodiment 7 preparations
Preparation method: the preparation method according to embodiment 13 makes tablet, every 0.5g.
For this situation is described, now by test example, further illustrate effect of the present invention as follows:
Test example 1 stability test
1. accelerated test
Get the tablet of embodiment 11, be divided into 3 batches, be numbered respectively sample 1, sample 2 and sample 3, at 40 ℃ ± 2 ℃ of temperature, under the condition that relative humidity is 75% ± 5%, place 6 months, at duration of test, sample respectively once 1 month, 2 months, 3 months, 6 the end of month, press the regulation in Chinese Pharmacopoeia, detect the character of tablet, the content of anisaldehyde (labelled amount %) found that, indices has no significant change;
Get the tablet of embodiment 12, under similarity condition, test, come to the same thing;
Getting the tablet of control Example 1,2, under similarity condition, test, all there is significant change in the character of tablet, the content of anisaldehyde (labelled amount %).
2. long term test
Get the tablet of embodiment 11, be divided into 3 batches, be numbered respectively sample 1, sample 2 and sample 3, at 25 ℃ ± 2 ℃ of temperature, under the condition that relative humidity is 60% ± 10%, place 24 months, at duration of test, sample respectively once 0 month, 3 months, 6 months, 9 months, 12 months, 18 months, 24 the end of month, press the regulation in Chinese Pharmacopoeia, detect the character of tablet, the content of anisaldehyde (labelled amount %) found that, indices has no significant change;
Get the tablet of embodiment 12, under similarity condition, test, come to the same thing;
Getting the tablet of control Example 1,2, under similarity condition, test, all there is significant change in the character of tablet, the content of anisaldehyde (labelled amount %).
From stability test, it is stable that the tablet of control Example 1,2 is not so good as the tablet of embodiment 11,12, this explanation, and Furcellaran can improve with propylene carbonate synergism the stability of tablet; In the amount ranges of the present invention's restriction, the good stability of tablet.
Test example 2 clinical trials
1. benefiting qi and nourishing blood
1. case selection:
Treatment group 1:32 example, age 30-50 year, average 38 years old, course of disease 2-7 week;
Treatment group 2:32 example, age 30-50 year, average 38 years old, course of disease 2-7 week;
Treatment group 3:32 example, age 30-50 year, average 38 years old, course of disease 2-7 week;
Matched group: 32 examples, age 30-50 year, average 38 years old, course of disease 2-7 week.
2. administering mode:
Treatment group 1: use benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement of the embodiment of the present invention 5, every day 2 times, warm water is taken after mixing it with water after meal, and be two weeks a course for the treatment of, uses continuously three courses for the treatment of;
Treatment group 2: use benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement of the embodiment of the present invention 8, every day 2 times, warm water is taken after mixing it with water after meal, and be two weeks a course for the treatment of, uses continuously three courses for the treatment of;
Matched group: oral FUKANGBAO KOUFUYE (composition: Radix Rehmanniae Preparata, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Folium Artemisiae Argyi, Radix Angelicae Sinensis, Radix Glycyrrhizae, Colla Corii Asini, adjuvant is brown sugar), every day 2 times, one after each meal, be two weeks a course for the treatment of, uses continuously three courses for the treatment of.
3. classical symptom: giddy, tinnitus, headache, insomnia, dreaminess, cutis laxa, microgroove, eye pouch, health are weak, easily tired.
4. diagnostic criteria:
Recovery from illness: clinical symptoms disappears completely.
Effective: clinical symptoms disappears substantially.
Effective: clinical symptom relief.
Invalid: substantially unchanged.
5. result of the test:
The curative effect comparative result for the treatment of group and matched group is in Table 1;
The curative effect comparison of table 1 treatment group and matched group
From treatment group 1,2 and matched group to the curative effect of benefiting qi and nourishing blood relatively, treatment group and matched group relatively have diversity (P < 0.05), illustrate that benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions curative effect of improvement are significantly increased with respect to matched group.
6. effect is judged: benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, and effective percentage 100%, cure rate 93.8%, can effectively treat benefiting qi and nourishing blood, effective percentage and cure rate are all higher, good effect, the cycle is short, and curative effect is significantly better than matched group.
2. toxin expelling Fructus Alpiniae Oxyphyllae
1. case selection:
Treatment group 1:33 example, age 28-52 year, average 35 years old, course of disease 2-7 week;
Treatment group 2:33 example, age 28-52 year, average 35 years old, course of disease 2-7 week;
Matched group: 33 examples, age 28-52 year, average 35 years old, course of disease 2-7 week.
2. administering mode:
Treatment group 1: use benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement of the embodiment of the present invention 5, every day 2 times, warm water is taken after mixing it with water after meal, and be two weeks a course for the treatment of, uses continuously three courses for the treatment of;
Treatment group 2: use benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement of the embodiment of the present invention 8, every day 2 times, warm water is taken after mixing it with water after meal, and be two weeks a course for the treatment of, uses continuously three courses for the treatment of;
Matched group: oral cedar seed is grown heart ball (composition: Semen Platycladi, Fructus Lycii, Rhizoma Acori Graminei, Radix Scrophulariae, Radix Glycyrrhizae (processing), Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Poria), and every day 3 times, warm water is taken after mixing it with water after meal, and be two weeks a course for the treatment of, uses continuously three courses for the treatment of.
3. classical symptom: easily sick, insomnia, dreaminess, hypomnesis, absent minded.
4. diagnostic criteria:
Recovery from illness: clinical symptoms disappears completely.
Effective: clinical symptoms disappears substantially.
Effective: clinical symptom relief.
Invalid: substantially unchanged.
5. result of the test:
The curative effect comparative result for the treatment of group and matched group is in Table 2;
The curative effect comparison of table 2 treatment group and matched group
From treatment group 1,2 and matched group to the curative effect of toxin expelling Fructus Alpiniae Oxyphyllae relatively, treatment group and matched group relatively have diversity (P < 0.05), illustrate that benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions curative effect of improvement are significantly increased with respect to matched group.
6. effect is judged: benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, effective percentage 100%, cure rate 93.9%, effectively toxin expelling Fructus Alpiniae Oxyphyllae, effective percentage and cure rate are all higher, good effect, the cycle is short, and curative effect is significantly better than matched group.
Typical case's application 1:
Lee, female, 29 years old, iron deficiency anemia, dim complexion, fatiguability.With the medicine of crossing multiple benefiting qi and nourishing blood, effect is all undesirable.Treatment: use the tablet being made by benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement by the course for the treatment of, every day 2 times, warm water is taken after mixing it with water after meal, and be two weeks a course for the treatment of, uses continuously three courses for the treatment of.Treat after 1 course for the treatment of, patient's symptom alleviates.Continue to use 1 course for the treatment of, symptom disappears completely.Continue to use 1 course for the treatment of, consolidated.Follow-up investigation is found after 1 year without recurrence.
Typical case's application 2:
Zeng, female, 47 years old, anemia, emaciated physique, yellowish complexion dried and withered hairs.With the medicine of crossing multiple benefiting qi and nourishing blood, effect is all undesirable.Treatment: use by benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement or tablet by the course for the treatment of, every day 2 times, warm water is taken after mixing it with water after meal, and be two weeks a course for the treatment of, uses continuously three courses for the treatment of.Treat after 1 course for the treatment of, patient's symptom alleviates.Continue to use 1 course for the treatment of, symptom disappears completely.Continue to use 1 course for the treatment of, consolidated.Follow-up investigation is found after 1 year without recurrence.
Typical case's application 3:
Lee, female, 32 years old, easily sick, insomnia, dreaminess, hypomnesis, absent minded.With the medicine of crossing multiple toxin expelling Fructus Alpiniae Oxyphyllae, effect is all undesirable.Treatment: use the tablet being made by benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement by the course for the treatment of, every day 2 times, warm water is taken after mixing it with water after meal, and be two weeks a course for the treatment of, uses continuously three courses for the treatment of.Treat after 1 course for the treatment of, patient's symptom alleviates.Continue to use 1 course for the treatment of, symptom disappears completely.Continue to use 1 course for the treatment of, consolidated.Follow-up investigation is found after 1 year without recurrence.
Typical case's application 4:
Liu, man, 41 years old, insomnia, dreaminess, hypomnesis.With the medicine of crossing multiple toxin expelling Fructus Alpiniae Oxyphyllae, effect is all undesirable.Treatment: use by benefiting qi and nourishing blood of the present invention, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement or tablet by the course for the treatment of, every day 2 times, warm water is taken after mixing it with water after meal, and be two weeks a course for the treatment of, uses continuously three courses for the treatment of.Treat after 1 course for the treatment of, patient's symptom alleviates.Continue to use 1 course for the treatment of, symptom disappears completely.Continue to use 1 course for the treatment of, consolidated.Follow-up investigation is found after 1 year without recurrence.
Claims (10)
1. benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, is characterized in that, described compositions comprises that following bulk drugs is prepared from through processing:
Fructus Anisi Stellati, walnut shell, willow mulberry; Or,
Fructus Anisi Stellati, walnut shell, Flos Salicis Babylonicae.
2. benefiting qi and nourishing blood according to claim 1, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, is characterized in that described compositions comprises that the crude drug of following weight portion is prepared from through processing:
Fructus Anisi Stellati 0.5-5 walnut shell 0.5-5 willow mulberry 0.5-5; Or,
Fructus Anisi Stellati 0.5-5 walnut shell 0.5-5 Flos Salicis Babylonicae 0.5-5.
3. benefiting qi and nourishing blood according to claim 2, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, is characterized in that, described compositions comprises that the crude drug of following weight portion is prepared from through processing:
Fructus Anisi Stellati 1.5 walnut shell 1.5 willow mulberrys 1; Or,
Fructus Anisi Stellati 1.5 walnut shell 1.5 Flos Salicis Babylonicae 1.
4. the preparation being made by benefiting qi and nourishing blood claimed in claim 2, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement and adjuvant, is characterized in that, described preparation is oral formulations, and described oral formulations comprises tablet, capsule, drop pill or powder; The ratio of weight and number of described compositions and adjuvant is 1:0.5-3.
5. preparation according to claim 4, is characterized in that, described oral formulations is tablet, and described adjuvant comprises that parts by weight are the propylene carbonate of 10-28 and the Furcellaran that parts by weight are 5-10.
6. preparation according to claim 5, is characterized in that, described adjuvant also comprises that parts by weight are the polacrilin potassium of 3-8 and the Oleum Ricini that parts by weight are 5-10.
7. a preparation method for the benefiting qi and nourishing blood described in claim 1-3 any one, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, is characterized in that, described method comprises the steps:
Take each raw material of recipe quantity, dry respectively also porphyrize and obtain fine powder, by each fine powder mix homogeneously, obtain benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement.
8. a preparation method for the benefiting qi and nourishing blood described in claim 1-3 any one, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, is characterized in that, described method comprises the steps:
A) take Fructus Anisi Stellati, the walnut shell two taste raw materials of recipe quantity, decoct with water three times, amount of water is 10 times of described two taste Chinese medicine gross weights for the first time, decocts 3h; Amount of water is 7 times of this two tastes Chinese medicine gross weight for the second time, decocts 2h; Amount of water is 3 times of this two tastes Chinese medicine gross weight for the third time, decocts 1h; Merge decoction liquor, filter, filtrate is concentrated into the extractum that relative density is 1.20-1.25, adds 95% ethanol and carries out precipitate with ethanol, filters, and filtrate is concentrated, at 40 ℃ spraying dry, make fine powder 1;
B) take willow mulberry or the Flos Salicis Babylonicae of recipe quantity, add alcohol reflux three times, add for the first time the ethanol of 10 times of amounts 90%, reflux, extract, 5h; The ethanol that adds for the second time 7 times of amounts 90%, reflux, extract, 3h; The ethanol that adds for the third time 4 times of amounts 90%, reflux, extract, 1h; Merge backflow, filter, filtrate is concentrated, and at 40 ℃, spraying is dried, and makes fine powder 2;
C), by fine powder 1 and fine powder 2 mix homogeneously, obtain benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement.
9. a preparation method for preparation claimed in claim 6, is characterized in that, described method comprises the steps:
A) prepare compositions;
B) Furcellaran of 3/4 recipe quantity and propylene carbonate are placed in to mortar, the compositions that slowly adds step a) to make under grinding, continues to grind 1h, and rotating speed is 250rmp, takes out, and crosses 120 mesh sieves, makes solid dispersion;
C) by the Furcellaran of 1/4 recipe quantity, step b) the Oleum Ricini mix homogeneously of the solid dispersion making, the polacrilin potassium of recipe quantity, 1/2 recipe quantity, obtain mixed powder;
D) by step c) mixed powder that makes granulates, and carry out granulate, and add the Oleum Ricini of 1/2 recipe quantity, mix homogeneously, tabletting, makes tablet.
10. benefiting qi and nourishing blood according to claim 2, toxin expelling Fructus Alpiniae Oxyphyllae, Yin Yang balancing, the microcirculatory compositions of improvement, preparing benefiting qi and nourishing blood, toxin expelling Fructus Alpiniae Oxyphyllae, or the application in Yin Yang balancing, the microcirculatory medicine of improvement.
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