Summary of the invention
The object of the invention is to overcome the deficiency that existing market benefit gas protects brain product, provide a kind of beneficial gas to protect brain tea, have beneficial gas and mend brain, promoting blood circulation and removing blood stasis, tonifying Qi is up, the effect of nourishing qi and blood.
Another object of the present invention is to provide the preparation method that above-mentioned beneficial gas protects brain tea.
For addressing the above problem, the present invention is achieved by the following technical solutions: a kind of beneficial gas protects brain tea, it is characterized in that: calculate by weight, formula comprises: fruit of Chinese wolfberry 8-13g, Radix Astragali 9-13g, Radix Angelicae Sinensis 14-18g, radix paeoniae rubrathe 9-14g, cassia twig 9-12g, safflower 12-15g, peach kernel 9-14g, ginger 3-5g, chrysanthemum 6-9g, Ligusticum wallichii 6-8g, earthworm 18-20g, baiyao 10-12g, date 15-20g.
Preferably, calculate by weight, formula comprises: fruit of Chinese wolfberry 12g, Radix Astragali 11g, Radix Angelicae Sinensis 15g, radix paeoniae rubrathe 12g, cassia twig 11g, safflower 14g, peach kernel 12g, ginger 4g, chrysanthemum 8g, Ligusticum wallichii 7g, earthworm 18g, baiyao 12g, date 18g.
Above-mentioned beneficial gas protects the preparation method of brain tea, it is characterized by;
(1) extract: by fruit of Chinese wolfberry 12g, Radix Astragali 11g, Radix Angelicae Sinensis 15g, radix paeoniae rubrathe 12g, cassia twig 11g, safflower 14g, peach kernel 12g, ginger 4g, chrysanthemum 8g, Ligusticum wallichii 7g, earthworm 18g, baiyao 12g, date 18g.Put into frying pan and soak 30min, decoct twice, decoct for the first time as 60min, retain filtrate, add 3 times of water and again decoct 40min, merging filtrate after filtering, is condensed into 1: 1, add 90% ethanol, limit edged stirs, and makes alcohol content reach 65%, standing its precipitation that makes, get its supernatant, heating simmer down to medicinal extract is standby.
(2) prepare softwood: add sucrose, dextrin, mix, then add appropriate 90% ethanol, limit edged stirs, and softwood processed is standby after the oven drying 20min of 50 ℃.
(3) whole grain: cross 20 mesh sieves, sterilization packing and get final product.
Wherein, in formula, the effect of each component is as follows:
The fruit of Chinese wolfberry: property is sweet, flat, returns liver, kidney channel.Have nourishing liver and kidneyly, the effect of benefiting shrewd head, loses for consumptive disease essence, soreness of waist and knee joint, and dizzy tinnitus, interior heat is quenched one's thirst, and the deficiency of blood is sallow, and blurred vision is not clear etc.2005 editions > > of < < Chinese pharmacopoeia, its pharmacological action has: 1, Blood pressure regulation, fruit water-soluble extractive 20mg/kg intravenous injection can make anesthetized rabbit Blood pressure drop, respiratory stimulant; Injecting atropine cuts off both sides vagus nerve can eliminate its hypotensive effect; Extrasomatic rabbit heart is to inhibitory action, and makes rabbit ear vessel retraction, methyl alcohol, acetone and other organic solvent extract also have slight hypotensive effect.2, antifatigue effect, the impact of fruit of Chinese wolfberry decoction on mouse hydroxyproline content and resistance to anoxic and antifatigue effect: hydroxyproline (Hydroxyproline) is the seed amino acid in collagenous fibres and protein, is proline hydroxylation.Human body, in aging course, because oxygen is under-supply, affects the dihydroxylation process of proline, thereby causes in the elderly's collagen hydroxyproline content low, and main organs is dwindled distortion, weight saving.Because PFT is influenced, lung capacity declines, and reserve capabillity reduces, and resistance goes down, and muscular strength declines, and resistance to anoxic, anti-fatigue ability decline.Therefore hydroxyproline content is with old and feeble relevant.Fruit of Chinese wolfberry decoction (13.23% concentration) gives mouse stomach 0.3ml/20g, every day 1 time, after 30 days hydroxyproline concentration with compare increment rate and reach 15.49%.Fruit of Chinese wolfberry decoction gives its hypoxia-bearing capability of mouse peritoneal injection 0.3ml/20g and within 27.9 ± 1.3 minutes, compares with control group life span, and matrimony vine is 37.5 ± 2.5 minutes (P < 0.01).Antifatigue experimental and control more also has the difference (P < 0.01) of highly significant.3, the impact on immunologic function, there is the effect of the nospecific immunity of enhancing, mouse gavaging fruit of Chinese wolfberry water extract or intramuscular injection alcohol extract and LBP-X, the phagocytic function of macrophage is improved, strengthen the effect of serum lysozyme, improve tiring of anti-sheep red blood cell (SRBC) antibody in serum, can also increase the quantity of the antibody forming cell of anti-sheep red blood cell (SRBC) in mouse spleen.4, delaying senility function, fructus lycii extracted solution 0.5mg/kg mouse stomach, can obviously suppress liver LPo totally on the 20th and generate, and blood two-story valley peptide peroxidase (GSH-Px) vigor and erythrocyte superoxide dismutase (SOD) vigor are improved; Human trial shows that can obviously suppress serum LPo generates, and GSH-Px vigor in blood is increased, but erythrocyte sod vigor has no rising, and prompting fructus lycii extracted solution has delaying senility function, takes lycium barbarum in the present invention.
The Radix Astragali: property is sweet, warm, returns lung, the spleen channel, has invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, the effect of expelling pus and promoting granulation, weak for the deficiency of vital energy, anorexia and loose stool, the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, the uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer is difficult bursts, and bursts and does not hold back for a long time, and flaccidity of limbs due to deficiency of blood is yellow, and interior heat is quenched one's thirst; Chronic nephritis albuminuria, 2005 editions > > of the < < Chinese pharmacopoeia such as diabetes, it is the formula of commonly using simply.Its main pharmacological is " invigorating qi for consolidating superficies ", can " Li Shui ", also can " promoting pus discharge and tissue regeneration " its pharmacological action have: 1, can strengthen normal heart and shrink, the heart of exhaustion is had to cardiotonic.2, bacteriostatic test: this product all has inhibitory action to Shigella shigae, bacillus anthracis, α-hemolytic streptococcus, beta hemolytic streptococcus, corynebacterium diphtheriae, bacillus pseudodiphthericus, Diplococcus pneumopniae, staphylococcus aureus, Staphylococcus citreus, hay bacillus etc. in vitro, takes astragalus mongolicus in the present invention.
Radix Angelicae Sinensis: property is sweet, pungent, warm, returns liver, the heart, the spleen channel, and having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, and the effect relaxing bowel, sallow for the deficiency of blood, dizzy palpitaition, irregular menstruation, through closing dysmenorrhoea, asthenia cold abdominalgia, the dry constipation of intestines, arthralgia due to wind-dampness, injury from falling down, ulcer sores.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine activating blood to promote menstruation, through closing dysmenorrhoea, arthralgia due to wind-dampness, 2005 editions > > of the < < Chinese pharmacopoeia such as injury from falling down, its pharmacological action has: 1, antiasthmatic effect, and the traditional Chinese medical science thinks, Radix Angelicae Sinensis cures mainly cough with dyspnea.Now prove, Radix Angelicae Sinensis composition n-butene husband's lactone and Ligustilide have relexation to tracheal smooth muscle; And the bronchial astehma that can cause antihistamine-acetylcholine.2, the effect to metabolism, proves by advanced technologies such as countercurrent immunoelectrophoresis, tagging and Electronic Speculum, Radix Angelicae Sinensis can make the liver cell of in vitro culture, and protein is synthetic to be increased, and DNA, RNA synthetic had to facilitation.Clinical confirmation, Radix Angelicae Sinensis can make patient's thymol turbidity reduce.Radix Angelicae Sinensis meals are raised mouse, and hepatic tissue endogenous is breathed and strengthened, and the ability of oxidation glutamic acid significantly improves.Hepatic lesion due to carbon tetrachloride is had to protective effect, and can prevent that liver glycogen from reducing.Experiment and clinical all proofs, Radix Angelicae Sinensis has effect for reducing blood fat to hyperlipidemia, and its effect is similar with medicines such as clofibrates.2.3-diphosphonic acid in animal and human's cells in-vitro is generated and has facilitation, reduce the affinity of hemoglobin and oxygen, promote band oxygen hemoglobin in tissue, to discharge oxygen, thereby increased the function of red blood cell transportation oxygen.3, the anti-oxidant and effect of removing free radical, Radix Angelicae Sinensis to cerebral anoxia, postischemic reperfusion cerebrum lipid peroxide increases obvious inhibitory action.Contained forulic acid has direct minimizing H2O2 content, and is combined with membrane phospholipid acyl monoethanolamine, by direct elimination free radical, suppresses the infringement of the antagonism radical pair tissues such as oxidation reaction and radical reaction, takes Radix Angelicae Sinensis top in the present invention.
The radix paeoniae rubrathe: property is bitter, be slightly cold, returns Liver Channel, has clearing heat and cooling blood, and the effect of blood stasis removing analgesic, for febrile virulent maculae.Hematemesis and epistaxis, hot eyes tumour, liver-depressed hypochondrium pain, through closing dysmenorrhoea , Disorder lump in the abdomen stomachache, injury from falling down.2005 editions > > of < < Chinese pharmacopoeia such as the swollen sore of carbuncle, its pharmacological action has: 1, reducing blood lipid and anti arteriosclerosis effect radix paeoniae rubrathe medicinal extract sheet 5g (crude drug)/kg, take every day 1 time, be used in conjunction 10-15 week, make the total plasma cholesterol (Tch) of hyperlipemia rabbit, triacylglycerol (TG), LDL-C (LDL-Ch), C-VLDL (VLDL-Ch) significantly reduce; HDL-C (HDL-Ch) and HDL2-Ch are significantly higher than control group; Tch/HDL-Ch, Tch/HDL2-Ch, LDL-Ch/HDL-Ch and LDL-Ch/HDL2-Ch ratio significantly reduce, and make thromboxane A2/prostacyclin (TXA2/PGI2) ratio due to hyperlipidemia be tending towards normal simultaneously.In addition also can reduce plasma lipid peroxide (LPO), arterial wall lipid, calcium and phosphatide and Aortic Plaque area.The mechanism of radix paeoniae rubrathe anti arteriosclerosis with improve lipoprotein component ratio, reduce plasma lipid peroxide, reduce calcium and be deposited on arterial wall, suppress platelet aggregation, regulate TXA2/PGI2 balance and activated adenyl cyclase and to increase in arterial wall cAMP concentration etc. relevant.2, the derivative n-propyl gallate of other effect radix paeoniae rubrathe composition gallic acids has the ability of removing oxygen radical; mitochondrial swelling and the peroxidatic reaction of lipid that can obviously suppress the induction such as ferrous sulfate and vitamin C, can protective wire plastochondria 26S Proteasome Structure and Function normal.The radix paeoniae rubrathe without obvious effect, but can be removed enterospasm due to acetylcholine to normal isolated guinea pig ileum.Radix paeoniae rubrathe n-butanol extract 3g/kg hypodermic injection can promote the phagocytic function of reticuloendothelial system, increases liver weight, and Hemolysin formation and delayed allergy are had no significant effect.River red paeonia extract has remarkable inhibitory action to beta-hydroxy-Beta-methyl glutaric acid coacetylase and calcium ion channel blocker acceptor.The radix paeoniae rubrathe has stronger inhibitory action to shigella dysenteriae, typhoid bacillus and hemolytic streptococcus in vitro.Grass Chinese herbaceous peony decoction gavage, can make Rabbits ' Blood Sugar temporarily raise, and Paeonia anomala water-ol extract has remarkable calmness and certain analgesic activity, can also improve the acidity of gastric juice, improves a poor appetite and digestive function.In the present invention, take Chinese herbaceous peony top.
Cassia twig: property is pungent, sweet, temperature, the thoughts of returning home, lung, urinary bladder channel, there is sweating expelling pathogenic factors from muscles and skin, warming meridian, help yang transforming qi, the effect of the flat gas that spins, for anemofrigid cold, coldness and pain in the epigastrium, blood is cold through closing, joint pain, phlegm and retained fluid, oedema, palpitaition, 2005 editions > > of < < Chinese pharmacopoeia such as globefish run quickly, its pharmacological action has: 1, effect to central nervous system, a, sedation: cinnaldehydrum 250~500mg/kg gavage has obvious sedation to mouse, showing as spontaneous activity reduces, the multi-activity excessively that antagonism methyl propylamine produces, the anesthesia duration of the ataxia that rotating stick test produces and prolongation ciclobarbital soluble etc., b, analgesic activity: experiment show: cassia twig analgesic activity a little less than, mouse mouse tail pressurization stimulus method shows: cinnaldehydrum is without obvious analgesic activity, but to writhing response due to lumbar injection acetic acid, there is slight inhibitory action, reaction has inhibitory action to mouse acetic acid twisting for the alcohol extract of cassia twig and water extract, to mouse folder tail and the pain caused unrestraint effect of boiling hot tail, c, refrigeration function: cassia twig decoction, cinnamic acid or sodium cinnamate, to mouse normal body temperature and with the rabbit that generates heat due to typhoid fever, paratyphoid vaccine, all there are cooling, refrigeration function, Chinese ephedra is joined cassia twig has excitation to rat paw portion sweat gland secretion, therefore, numb osmanthus decoction perspiration is relevant with maincenter, d, anticonvulsant action: cinnaldehydrum 500mg/kg injects to mouse peritoneal, can delay tetanic convulsion and death time that strychnine causes, can reduce tetanic convulsion and dead incidence that nicotine causes, and the convulsions that pentetrazole causes is invalid.2, antivirus action: cultivate with the primary adhesion tissue of human embryo kidney (HEK), cassia twig decoction (1: 20) has inhibitory action to the 68-1 of the section strain of A type capital, influenza Asia and orphan virus (ECHO11).On chicken embryo, infected by influenza has inhibitory action, better with 70% alcohol preserved material effect.In the present invention, take cassia twig spray.
Safflower: property is pungent, warm, the thoughts of returning home, Liver Channel, have activating blood to promote menstruation, the effect of blood stasis removing analgesic, be used for through closing, dysmenorrhoea, lochia , Disorder lump in the abdomen lump in the abdomen, injury from falling down, 2005 editions > > of < < Chinese pharmacopoeia such as sore swells and ache, come from < < Bencao Tujing > >: " red blue flower, safflower also.The present has it everywhere.Other ground threshing is planted, and winter and cloth is in cultivated land, to raw seedling of spring, and Xia Naiyou flower, the lower Qiu that does converges, thorniness, pistil goes out in strain, and people from garden holds to reveal and adopts it, adopts and appears again, to stopping to the greatest extent.Solid in Qiu, white, as large in red bean.It spends suddenly and violently dry very red to dye, and makes swallow fat.After main product, blood is sick for winning, in fact also same, and leaf is quite like blue, therefore there be blue." < < book on Chinese herbal medicine states the > > of hook unit: " broken blood wine boils for red blue flower, the decocting that nourishes blood."; its pharmacological action has: the impact of the encephaledema that 1, safflower causes animal used as test cerebral arterial thrombosis: application Sofflower injection (1ml includes crude drug 1g); 63 mongolian gerbils are carried out to preoperative 30 minutes ip and award 10g/kg Sofflower injection; and set up operative control group and sham-operation group; and observe the impact of safflower on ischemic brain edema, and studied the variation of the Monoamine in same brain district.Results suggest safflower alleviates the mechanism of ischemic brain edema, and to affect in tissue the metabolic disorder of monoaminergic transmitters relevant with it.And further confirm that safflower can reduce incidence of stroke and the death rate really, the brain tissue of experimental chest infraction animal is had to protective effect.2, antifatigue effect: relatively, swimming time obviously extends for carthamin yellow 1100mg/kg mouse and control group (using equivalent physiological saline), and rate elongation reaches 117.0%, P < 0.01.3, immunocompetence: safflower polysaccharide is different from the polysaccharide that in higher plant, a-key connects, is similar to the polysaccharide of bacterial origin.From external pouring, turn experiment and show, safflower polysaccharide and the former ConA of T cell mitogenesis have synergy, and to B cell mitogenesis, former Dex-TCMLIBansulfate has no significant effect.But PFC test in body, safflower polysaccharide with it is generally acknowledged that to act on the astragalus polyose effect trend of B cell consistent.Give the asynchronism(-nization) of injected in mice safflower polysaccharide, the variation of mouse PFC value is also different: after sensitization, the PFC of administration group is promoted, and before sensitization, the PFC of administration group is anti-suppressed.Show that safflower polysaccharide has shown the amphicheirality of immune drug equally.Safflower polysaccharide can obviously resist the immunosuppressive action of prednisolone, and the immunological enhancement that it suppresses mouse to prednisolone is more obvious to the effect of normal mouse.Therefore, safflower polysaccharide can promote to drench cell transformation, increases the cell number of splenocyte to sheep red blood cell plaque test, and the immunosuppressive action of antagonism prednisolone etc., show that it is a kind of new, worth further immunomodulator of research.Another Safflor yellow (SY) reduces serum lysozyme content, peritoneal macrophage and whole blood phagocytic activity of leukocytes; PFC, SRFC and antibody are produced to be reduced; Suppress the Ts cell activation of DH reaction and SOI induction, external, SY0.03-3.0, generation and the activity thereof of the T that 0.1-2.0 and 0.1-2.5mg/ml inhibition TdR mix, bone-marrow-derived lymphocyte conversion, MLC reaction, IL2.4. pair neural effect: ip in mice carthamin yellow 0.55g/kg, 1.1g/kg, mouse to injection yellow Jackets sub-threshold dose 0.3g/kg or chloraldurate sub-threshold dose 0.25g/kg, all can improve the rate of falling asleep (P < 0.01, P < 0.001), explanation can obviously strengthen the central inhibitory action of yellow Jackets and chloraldurate, and its action intensity becomes parallel relation with consumption.1.1g/kg carthamin yellow, to ip in mice, can obviously reduce mice convulsion reactivity and the death rate (P < 0.05) that nikethamidum causes, but can not resist convulsions and the death that pentylenetetrazol, caffeine and nitric acid one leaf alkali cause.Sofflower injection 10g/kg, to Mongolian sarsaparilla mouse ip, can reduce the incidence of stroke of a side left neck artery ligation, obviously alleviates the encephaledema being caused by cerebral apoplexy, and safflower reduction stroke incidence being described and alleviating encephaledema has certain relation.Because safflower can make a cyclic extention, increase the CBF of Cerebral Region, thereby alleviate encephaledema.Safflower can alleviate the metabolic disorder of monoaminergic transmitters in brain tissue again, makes the neurotransmitter declining recover normal or approach normal.This is also that safflower alleviates one of mechanism of encephaledema, takes extra dry red wine flower in the present invention.
Peach kernel: property is bitter, sweet, flat, the thoughts of returning home, liver, large intestine channel, have promoting blood circulation, the effect relaxing bowel, for through closing, dysmenorrhoea.Disorder lump in the abdomen lump in the abdomen, injury from falling down, 2005 editions > > of < < Chinese pharmacopoeia such as the dry constipation of intestines, its pharmacological action has: peach kernel extract can obviously increase cerebral blood flow (CBF), increase the CBF of dog femoral artery, reduce vascular resistence, improve hemodynamic situation.Extract can improve the liver surface microcirculation of animal, and promotes choleresis.Peach kernel can make the hemorrhage and clotting time of mouse obviously extend, and decoction has inhibitory action to external thrombus, and decocting liquid has fiber facilitation.In peach kernel, contain 45% fat oil Castor Oil enteron aisle, be beneficial to defecation.In the present invention, take stir-baked SEMEN PERSICAE.
Ginger: property is pungent, tepor, return lung, spleen, stomach warp, there is loose the trembling with fear of inducing sweat, warming middle energizer to arrest vomiting, the effect of preventing phlegm from forming and stopping coughing, for anemofrigid cold, gastrofrigid vomiting, cold productive cough 2005 editions > > of < < Chinese pharmacopoeia such as cough, its pharmacological action has: 1, effect to the circulatory system and respiratory system, shogaol extract has excitation to anesthetized cat vasomotor center and respiratory center, heart is also had to direct excitation, normal person's chewing ginger 1g (not swallowing), can make the systolic pressure 1.489kPa (11.2mmHg) that on average raises, diastolic pressure rising 1.862kPa (14mmHg), pulse frequency is had no significant effect.2, the effect to central nervous system, ginger has inhibitory action to central nervous system, and oil of ginger can obviously suppress spontaneous activity in mice, extends yellow Jackets lengths of one's sleep, and antagonism pentylenetetrazol is fainted from fear, analgesia, and can reduce yeast pyrogenicity rat temperature.To the site of action of nervous centralis, be the above level of spinal cord, its mechanism may have certain to contact with the facilitation process that suppresses excited cynapse.Oil of ginger 0.4ml/kg, to rat oral gavage, swells and has remarkable inhibitory action egg white foot, and effect maintains 5 hours, and intensity is similar to aspirin 300mg/kg; 0.25ml/kg, to rat oral gavage, can significantly suppress granuloma induced by implantation of cotton pellets, and make atrophy of thymus gland, and adrenal gland weight increases, and points out its antiinflammatory action may be relevant with excited Pituitary Adrenal cortex system.Oil of ginger 0.25~0.4ml/kg gavage, capillary permeability strengthens due to the swelling of paraxylene induced mice auricle, histamine or acetic acid remarkable inhibitory action.Mouse peritoneal injection fresh ginger parenteral solution 5g/kg or 10g/kg, have obvious analgesic activity.3, antioxidation, research shows: ginger Wheat Protein.In lard, add 5%~10% ginger splices to boil 1~4 hour, can prevent that pork is corrupt; By this method, boil the fat meat of 4 hours, its peroxide number (POV) is similar to bright lard with thiobarbital acid number (TBA); Add 20% or 50% ginger to boil the lard of 4 hours, place 90 at the temperature of 30 ℃, its POV and TBA almost do not change.The water of ginger, ethanol and
etherextract also has remarkable inhibitory action to the oxidation of linoleic acid potassium ester.Still there is report to point out, add active oxygen scavenger or ginger extract, can suppress the DNA damage that lipid peroxidation causes; Ginger extract also can suppress generation and the linoleic oxidation of active oxygen.In the present invention, take ginger rhizome.
Chrysanthemum: property is sweet, bitter, be slightly cold, return lung, Liver Channel, there is loose wind heat-clearing, the effect of flat liver improving eyesight, for anemopyretic cold, have a headache dizzy, red eye, swell pain, 2005 editions > > of < < Chinese pharmacopoeia such as eyes is dim-sighted, its pharmacological action has: 1, the phenol position of cardiovascular aspect pharmacological action chrysanthemum can increase guinea pig isolated heart coronary flow, improve the tolerance of mouse to hypobaric hypoxia, and to the heart of rabbit, liver, renal function without overt toxicity effect.The total extract of chrysanthemum all shows to have positive inotropic action to isolated heart, cardiac muscle cell, and FLOS CHRYSANTHEMI ALBA from Haizhou of China has the rat ventricular of anti-Aconitine Induced, and the mouse Arrhythmia that brings out of chloroform.2, anti-aging effects chrysanthemum can strengthen glutathione peroxidating reduction, obviously extends the silkworm life-span; Can also improve mouse heart and brain resisting oxygen lack; the ability that extends its life span and remove free radical; someone studies and finds; to biomembranous ultra-oxygen anion free radical, damage has obvious protective effect to chrysanthemum extract, is mainly to shield after directly entering the glyceride of cell membrane.This new discovery makes chrysanthemum be expected to exploitation becomes new functional food, especially in antisenility cistanche food, brings into play its effect.In the present invention, take Hang Ju.
Ligusticum wallichii: property is pungent, warm, returns liver, courage, pericardium channel, has blood-activating and qi-promoting, the effect of wind-expelling pain-stopping, and for irregular menstruation, through closing dysmenorrhoea , Disorder lump in the abdomen stomachache, the shouting pain of the chest side of body, tumbling and swelling, headache.2005 editions > > of the < < Chinese pharmacopoeia such as arthralgia due to wind-dampness, its pharmacological action has: 1, the effect to central nervous system, Ligusticum wallichii has obvious sedation.Activity to animal brain when rhizoma chuanxiong volatile oil is a small amount of is inhibited, and medulla oblongata respiratory center, vasomotor center and spinal reflex maincenter are had to excitation.Ligusticum wallichii decoction all can suppress its spontaneous activity to respectively large and small mouse ig, and the mouse sleep time that yellow Jackets cause is extended, and the excitation that can resist caffeine (20mg/kg).But the rat that can not resist due to pentylenetetrazol is fainted from fear.By Ligusticum wallichii decoction 25-50g/kg gavage, can suppress the spontaneous activity of rat, more obvious compared with rat to the calmness of mouse; It can also extend the length of one's sleep of amobarbital, but excitement that can not antagonism caffeine, can not prevent convulsions or the lethal effect of leptazol, cocaine.The volatile oil part of Japan's product Ligusticum wallichii is inhibited to the activity of animal brain, and the vasomotor center respiratory center of medulla oblongata and spinal reflex are had to excitation, and dosage strengthens, and all transfers inhibition to.2, anti-radiation function, Ligusticum wallichii decoction has certain curative effect to animal radiation sickness experimental therapy.The water-soluble crude preparation by using of Ligusticum wallichii all has protective effect to the radiation exposure of rat, mouse and dog and mustargen damage.Ligusticum wallichii is better than mouse to the anti-effect of penetrating of rat, and ip is better than im administering effect, and im administration is effective compared with ig.In the present invention, take Rhizome of Ligusticum Sinense Oliv. Cv. Chuanxiong.
Earthworm: property is salty, cold, returns liver, spleen, urinary bladder channel, has heat-clearing arresting convulsion, and dredging collateral, relievings asthma, the effect of diuresis, and for unconsciousness due to high fever, frightened sick tic, joint pain, extremity numbness, hemiplegia.Dyspnea and cough due to lung-heat, oliguria oedema; 2005 editions > > of the < < Chinese pharmacopoeia such as hypertension, its pharmacological action has; 1, to neural effect, treatment cerebral arterial thrombosis (apoplexy): lumbar injection earthworm injection 10g/kg in advance, mongolian gerbils one is surveyed to the pre-always cerebral arterial thrombosis that artery ligation causes and there is certain prevention effect, can alleviate the symptom of cerebral arterial thrombosis, as the incidence of piloerection, turn-take behavior and the outbreak of rolling about etc. declines, and obviously reduce the death rate of animal, monoamine transmitters 5 one hydroxytryptamines and the dopamine that have made to reduce in cerebral arterial thrombosis animal brain are tending towards recovering, and Noradrenaline Contents is had no significant effect.Anticonvulsion and sedation: the extract that mouse peritoneal injection earthworm lead acetate is processed, can obviously resist the convulsions that pentylenetetrazol and caffeine cause, but the convulsions rather causing that can not resist soil, pointing out its anticonvulsant action position is the nervous centralis position more than spinal cord.Mouse peritoneal injection earthworm alcohol leaching liquid 20g/kg, also has antagonism to electrofit, and ED is 22.18g/kg.The immersion liquid of earthworm alcohol has sedation to mouse, rabbit.Refrigeration function: the heating rabbit that earthworm water logging agent causes escherichia coli endotoxin and warm stimulation all has good refrigeration function, but compared with a little less than the effect of aminopyrine.The oral LUMBRICUS 12g that falls apart, Healthy People body temperature, without reducing effect, is better than to aspirin (oral 0.3g) to fever caused by infection patient cooling effect also effective to noninfectious fever, but effect appearance is more late, generally effective in the approximately rear 0.5-3h of clothes, 2-5h body temperature is down to normally.In the present invention, take dry earthworm.
Baiyao; There is wines used as antirheumatic; The effect of pain relieving, for arthralgia due to wind-dampness; Injuries from falls as well heat-clearing dissolving phlegm, removing pattogenic heat from the blood and toxic material from the body, pain relieving.Cure mainly and control pharyngalgia larynx numbness, cough, spit blood, bleeding from five sense organs or subcutaneous tissue, gold is created blood, and hot malicious carbuncle is swollen, scrofula, its drug action has: < < Illustrated Book on Plants > >: " suffer from dentalgia person, Qie Qigen pastes on gum, the energy tonifying kidney and nourishing yin of holding concurrently ".Chinese herbal medicine handbook > > is commonly used in < < Hunan Rural Areas: " removing toxic substances of dispeling the wind, clearing and activating the channels and collaterals ".< < property of medicine opinion > >: " control plug heat in larynx, the numbness of choking is obstructed, and mountain pass plug, bitterly normal in pharynx in the heart, swelling ".In the present invention, take baiyao root.
Date: property is sweet, warm, return spleen, stomach warp, there is tonifying middle-Jiao and Qi, the effect of nourishing blood and tranquilization, few for the empty food of board, weak loose stool, 2005 editions > > of the < < Chinese pharmacopoeia such as hysteria of womam, red date has the effects such as qi-restoratives benefit gas, nourishing blood and tranquilization, strengthening the spleen and stomach, and red date has good therapeutic effect to illnesss such as chronic hepatitis, cirrhosis, anaemia, anaphylactoid purpuras; Red date contains triterpene compound and CAMP, has stronger anticancer, anti-allergic effects.Date can moisten cardiopulmonary, cough-relieving, tonifying five zang organs, it is deficient to control, except stomach addiction gas, in can also pacifying, support spleen, flat stomach Qi, logical nine orifices, help 12 through etc., its pharmacological action has: 1, immunosuppressive action, the alcohol extract of date with every day 100mg to rat oral gavage, show that date and imuran have same immunosuppressive action, can suppress the generation of antibody to atopic diseases.Date alcohol extract may have inhibitory action to rat reactive antibody, and non-reacted antibody is not produced to inhibitory action.2, promote sleep, pharmacological research is found, in date, contain various bioactivators, human body is had to the plurality kinds of health care effect of curing the disease, date has the effects such as qi-restoratives benefit gas, nourishing blood and tranquilization, strengthening the spleen and stomach, is the good health nutrients of patient such as weakness of the spleen and the stomach, insufficiency of vital energy and blood, lassitude, insomnia and dreamful sleep.From clinical practice, take date for the slight insomnia good auxiliary curing of can yet be regarded as.As ineffective, can suitably use stable control, but can not long-term taking.Long-term taking is stable to be had compared with major injury health, and as patient produces drug dependence, should cut down according to the circumstance stable use the treatment of employing formula as formula etc. have curative effect comparatively significantly as far as possible.In addition, insomniac should cultivate good habits and customs, as take a walk after supper, usually does more physical exercises etc. more, and these recoveries for sleep all have good help.
A kind of beneficial gas of the present invention protects brain tea, and its formula be take the Radix Astragali as main side, and the vigour of large tonifying spleen and stomach, makes the prosperous blood of gas, and the stasis of blood is removed ruton; Radix Angelicae Sinensis, red date is invigorated blood circulation to be longer than, double can nourishing blood, stagnation resolvation and non-blood trouble wonderful, is aided with the radix paeoniae rubrathe, Ligusticum wallichii, peach kernel, safflower, cassia twig, baiyao, ginger, helps Radix Angelicae Sinensis promoting blood circulation, warming meridian, helps yang transforming qi, wines used as antirheumatic; Assistant is with earthworm, chrysanthemum, the fruit of Chinese wolfberry, dredging collateral, heat-clearing, flat liver kidney-nourishing, coordinate with the Radix Astragali, strengthens the power of invigorating qi and dredging collateral, all row whole bodies, each prescription complements each other, eliminating pathogen to support vital qi, and tonifying Qi matches with invigorating blood circulation, the prosperous blood of gas, invigorate blood circulation and don't just hinder, play altogether the merit of collaterals, prescription has advantages of that preparation is convenient, cheap, has no side effect, mouthfeel is good.
A kind of beneficial gas of the present invention protects brain tea and preparation method thereof, and its excellent feature is also:
One, all side's proportioning science, have the merit of qi and activate blood circulation dredging collateral, and its preparation is simple, easy to use, have no side effect:
Two, the tonifying Qi in formula can strengthen cellular immunity and increase antibody formation;
Three, in formula, promoting blood circulation and removing blood stasisly can change blood flow viscosity;
Four, can dredge capillary of kidney, suppress ephritis development, and can control albuminuria;
Five, energy dissipating phlegm for resuscitation dredging collateral, improves local circulation, recovers blood flow and vessel wall elasticity, and the limbs of attaching undue importance to one thing to the neglect of the other are comparatively fast recovered; ,
Six, take and mend as main, mend slip-knot and close, have the merit of strengthening vital QI to eliminate pathogenic factors;
Seven, a large amount of tonifying Qi with invigorate blood circulation and match on a small quantity, the prosperous blood of gas, invigorates blood circulation and don't just hinders, and has tool with the merit of playing collaterals;
Eight, for blood samples of patients in sticky, dense, solidifying, poly-tendency, after use, can increase the content of Cyclic Adenosine monophosphate in blood platelet, suppress platelet aggregation and release reaction, suppress and thrombus, to improve microcirculation, promote offshoot circulation.
The specific embodiment
The present invention is achieved by the following technical solutions: a kind of beneficial gas protects brain tea, it is characterized in that: calculate by weight, formula comprises: fruit of Chinese wolfberry 8-13g, Radix Astragali 9-13g, Radix Angelicae Sinensis 14-18g, radix paeoniae rubrathe 9-14g, cassia twig 9-12g, safflower 12-15g, peach kernel 9-14g, ginger 3-5g, chrysanthemum 6-9g, Ligusticum wallichii 6-8g, earthworm 18-20g, baiyao 10-12g, date 15-20g.
Preferably, calculate by weight, formula comprises: fruit of Chinese wolfberry 12g, Radix Astragali 11g, Radix Angelicae Sinensis 15g, radix paeoniae rubrathe 12g, cassia twig 11g, safflower 14g, peach kernel 12g, ginger 4g, chrysanthemum 8g, Ligusticum wallichii 7g.Earthworm 18g, baiyao 12g, date 18g.
A kind of beneficial gas of the present invention protects brain tea, and its preparation method is:
(1) extract: by fruit of Chinese wolfberry 12g, Radix Astragali 11g, Radix Angelicae Sinensis 15g, radix paeoniae rubrathe 12g, cassia twig 11g, safflower 14g, peach kernel 12g, ginger 4g, chrysanthemum 8g, Ligusticum wallichii 7g, earthworm 18g, baiyao 12g, date 18g.Put into frying pan and soak 30min, decoct twice, decoct for the first time as 60min, retain filtrate, add 3 times of water and again decoct 40min, merging filtrate after filtering, is condensed into 1: 1, add 90% ethanol, limit edged stirs, and makes alcohol content reach 65%, standing its precipitation that makes, get its supernatant, heating simmer down to medicinal extract is standby.
(2) prepare softwood: add sucrose, dextrin, mix, then add appropriate 90% ethanol, limit edged stirs, and softwood processed is standby after the oven drying 20min of 50 ℃.
(3) whole grain: cross 20 mesh sieves, sterilization packing and get final product.
Embodiment 1
By fruit of Chinese wolfberry 12g, Radix Astragali 11g, Radix Angelicae Sinensis 15g, radix paeoniae rubrathe 12g, cassia twig 11g, safflower 14g, peach kernel 12g, ginger 4g, chrysanthemum 8g, Ligusticum wallichii 7g, earthworm 18g, baiyao 12g, date 18g.Put into frying pan and soak 30min, decoct twice, decoct for the first time as 60min, retain filtrate, add 3 times of water and again decoct 40min, merging filtrate after filtering, is condensed into 1: 1, adds 90% ethanol, limit edged stirs, and makes alcohol content reach 65%, and standing its precipitation that makes, gets its supernatant, heating simmer down to medicinal extract is standby, adds sucrose, dextrin, mixes, add appropriate 90% ethanol, limit edged stirs, softwood processed again, standby after the oven drying 20min of 50 ℃, cross 20 mesh sieves, sterilization packing and get final product.
Embodiment 2
By fruit of Chinese wolfberry 11g, Radix Astragali 12g, Radix Angelicae Sinensis 16g, radix paeoniae rubrathe 13g, cassia twig 10g, safflower 13g, peach kernel 11g, ginger 5g, chrysanthemum 9g, Ligusticum wallichii 8g, earthworm 18g, baiyao 11g, date 19g.Put into frying pan and soak 30min, decoct twice, decoct for the first time as 60min, retain filtrate, add 3 times of water and again decoct 40min, merging filtrate after filtering, is condensed into 1: 1, adds 90% ethanol, limit edged stirs, and makes alcohol content reach 65%, and standing its precipitation that makes, gets its supernatant, heating simmer down to medicinal extract is standby, adds sucrose, dextrin, mixes, add appropriate 90% ethanol, limit edged stirs, softwood processed again, standby after the oven drying 20min of 50 ℃, cross 20 mesh sieves, sterilization packing and get final product.
A kind of beneficial gas of the present invention protects brain tea to blood-enrich, and metabolic promotion has obvious curative effects.It is below the clinical example of part.
Clinical example 1
Ancient certain, man, 35 years old, patient was because of after cerebral thrombus is in hospital and rescues, right side quadriplegia need not.Dysphasia, discomfort uncomfortable in chest, sound of the sputum in the throat, companion's painful swelling of joints, there is purple plague purpura on thin and greasy fur limit, wiry and rolling pulse.This is that the deficiency of vital energy can not be moved blood, and phlegm stasis blocking, in train of thought, belongs to apoplexy sequela, then adopts embodiment 2 products, closes reducing phlegm by resuscitation.Every day 2 times brews 300 milliliters at every turn, takes continuously after 1 month, and complexion is clearly better, dizzy transference cure, and lower limb are restore funcitons, can in person walk to treat-and-release.Though upper limbs can be movable, holds thing and still owe freely, speech is also normal.
Clinical example 2
Lee, man, 55 years old, patient was because of dizzy difficult the healing repeatedly of cervical spondylopathy retrogression pathological changes.When medical, see dizzy as sit journey, upper limbs fiber crops pain, time have insomnia, god is tired, feel sick, raw phlegm, tongue fur featheredge has the stasis of blood purple, qi deficiency to blood stasis and train of thought is obstructed, lucid yang failing to raise, adopts embodiment mono-product then, the all dirty gas of benefit, the blood of the whole body of living, to improve local blood circulation, promote neurological functional recovery, patient every day 2 times, brew 300 milliliters at every turn, take continuously after 20 days, cervical vertebra moving freely, no longer dizzy.
Clinical example 3
Week certain, female, 29 years old, patient engaged in educational work, and whenever hoarseness when frequent of teaching, through multi-treatment, had no effective.Heavy when light during hoarseness, dry throat, vertigo, body acid, occasionally has raw phlegm, and menses is uncomfortable, the light few tongue of tongue, small and wiry pulse.Through city, examination in hospital is diagnosed as singer's node, and the traditional Chinese medical science is examined as qi deficiency to blood stasis, and train of thought is unfavorable, and upper knot throat is controlled suitable qi and activate blood circulation, stagnation resolvation relieve sore throat.Press: plain body is weak, sings heartily for a long time, secretly consumes qi and blood, and blood operation is unfavorable, train of thought blood stasis, then adopt embodiment mono-product then to adopt embodiment bis-products, benefiting qi and removing blood stasis, activating collaterals and eliminating stagnation, patient every day 2 times, brew 300 milliliters at every turn, take continuously after 30 days, sound recovers as before, the satisfaction of producing effects.
Clinical example 4
Dragon certain, female, 60 years old.Patient has hypertension history.Numb limb while examining, trembles more than, though can stand, can not open step, and upper limbs shake causes can not hold thing.Vertigo, god is tired, and the lazy speech of breathing hard is vexed, uneasy sleeping at night.The red few tongue of tongue limit is purple, small and wiry pulse.Card belongs to qi deficiency to blood stasis, and pneumatic network resistance, adopts embodiment bis-products then, and Yiqi-Huoxue-Huayu shakes surely, patient every day 2 times, brews 300 milliliters at every turn, takes continuously after 15 days, trembles and subtracts greatly, can stride, and it is also gradually normal that upper limbs is held thing.