KR20190107845A - A drug for treating shoulder periarthritis and its preparation method - Google Patents

Abstract

The present invention discloses a medicine for treating shoulder periarthritis and a method for manufacturing the same. The medicine for treating shoulder periarthritis contains: 5 to 18 parts by weight of Sichuan cassia twig; 10 to 25 parts by weight of Codonopsis pilosula; 13 to 20 parts by weight of Carthamus tinctorius; 12 to 20 parts by weight of Pericateta communisma; and 5 to 15 parts by weight of Angelica gigas. The medicine for treating shoulder periarthritis according to the present invention has different components compared to a medicine of the prior art, and thus can overcome disadvantages of the medicine of the prior art.

Description

A drug for treating shoulder periarthritis, and a manufacturing method therefor {A DRUG FOR TREATING SHOULDER PERIARTHRITIS AND ITS PREPARATION METHOD}

FIELD OF THE INVENTION The present invention relates to the field of medicaments, in particular to medicaments for the treatment of shoulder periarthritis and methods of making the same.

Periarthritis of the shoulder is chronic aseptic inflammation of soft tissues such as muscles, tendons, bursae and joint capsules around the shoulder joint. Inflammation causes adhesion inside and outside the joint, affecting the activity of the shoulder joint. The shoulder periarthritis lesion is characterized by a wide range of pain, a wide range of functional limitations and a wide range of tenderness. The full name of the frozen shoulder is scapulohumeral periarthritis, and in the field of traditional Chinese medicine, the shoulder periarthritis is a wind-cold-invasion of the tendons and blood vessels around the shoulder. It was believed to be a chronic disease caused by wetness evil invasion. Due to the inconsistency between nutritive Qi and defensive Qi, muscles and bones weaken in the human body, exogenous pathogenic factors invade and injure the tendons and blood vessels around the shoulder, resulting in blockage of Gi and blood Cause pain.

Currently, drugs for the treatment of periarthritis of the shoulder may exhibit certain alleviating effects, but have the drawbacks of weak targeting, long treatment cycles and large side effects. Therefore, there is an urgent need for new drugs for treating periarthritis of the shoulders that overcome the above drawbacks.

In view of the above problems, the present invention provides a medicament for treating shoulder periarthritis that can solve the problems or at least some of the problems, which is used to overcome the drawbacks of the poor therapeutic effect of the medicaments of the prior art. do.

According to the first aspect, the present invention, in parts by weight, Sichuan cassia twig 5-18, Codonopsis pilosula 10-25, Safflower Carthamus 13-20, Lumbricus 12-20 and Provided is a medicament for treating shoulder periarthritis, including Angelica sinensis 5-15.

According to a second aspect, the present invention provides a method of making a medicament according to any one of the embodiments, comprising the following steps:

First step: weighing Sichuan Gye 5-18, Dangsam 10-25, Safflower 13-20, Earth Dragon 12-20 and Angelica 5-15 by weight;

Second step: grinding the raw materials to obtain a powder mixture;

Third step: immersing the mixture in water for 0.5-1 hour and decanting the resultant for 30 minutes under a big fire to obtain decoction;

Fourth Step: Cool the powder and filter it with 100-250 mesh filter cloth to obtain a filtrate, and concentrate the filtrate to a thick paste having a density of 1.2-1.25. Obtaining; And

Step 5: Drying the thick paste, grinding the dried product and sieving to obtain the desired agent.

The present invention discloses a medicament for treating periarthritis of the shoulder and a method of making the same. A medicament for treating shoulder periarthritis according to the present invention has other ingredients compared to the medicaments of the prior art and can overcome the drawbacks of the medicaments of the prior art.

In one embodiment of the present invention, there is provided a medicament for treating shoulder periarthritis, comprising Sichuan Gye 5-18, Dangsam 10-25, Safflower 13-20, Earth Dragon 12-20 and Angelica 5-15 by weight. .

In addition, the medicament further comprises Radix Clematidis 20-30 by weight.

In addition, the medicament further comprises Ramulus Mori 12-18 by weight.

The gastric glands and upper limbs are just some specific examples and are not intended to be limiting, and include other substances, eg wolfberry fruit, Gynostemma pentaphyllum, 12 Semen Astragali Complanati, Radix Dipsaci ), Herbal Eclipta (Herba Eclipta), Journey (Fructus Ligustri Lucidi) are also possible. Other possible materials will not be disclosed in detail.

Optionally, in one embodiment of the invention, substances that activate blood circulation, for example Carcuma longa and Evening Primrose, may be added.

In addition, in one embodiment of the present invention, in order to enhance the pharmacological effect, the medicament is a substance that removes heat, such as Gardenia Gardeniae, Semen Cassiae, Cortex fraxini, Radix Sophorae Flavescentis), wild chrysanthemum (Flos Chrysanthemi Indici), Cheonsimyeon (Andrographis paniculata) and the like may be further included.

In addition, the medicament may further include substances that remove moisture and promote diuresis, such as Herba Sedi, Abrus Herb, and the like.

In addition, the medicament may further include a substance for warming the inside, for example, pepper.

In one embodiment of the invention, the dosage form of the medicament is a film-coated tablet, dragee, enteric coated tablet, dispersible tablet, capsule, granule, decoction, mixture, syrup At least one of vinum, injection, oral solution, and oral turbid liquid.

In one embodiment of the invention, optionally, the medicament has an oral-dosage formulation.

In one embodiment of the invention, optionally, the oral-dose formulation comprises a tablet, capsule, pill, injection, sustained release preparation and controlled release formulation.

Agents of the embodiments provided herein or pharmaceutical compositions comprising the same may be administered in unit dosage form via intestinal tract, nasal, oral mucosa, eye, lung, respiratory tract, skin, rectum, or the like, oral administration , Intravenous injection, intramuscular injection and subcutaneous injection.

The dosage form can be a liquid dosage form, a solid dosage form, or a semi-solid dosage form. The liquid dosage forms can be solutions, emulsions, suspensions, injections (including hydration injections, powder injections and transfusions), eye drops, nasal drops, lotions and liniments. There is; The solid dosage forms can be tablets (uncoated tablets, enteric-coated tablets, buccal tablets, dispersible tablets, chewable tablets, effervescent tablets, orally disintegrating tablets). ), Capsules (including hard capsules, soft capsules, enteric capsules), granules, powders, pellets, dropping pills, suppositories, films, pastes, aerosols, sprays, and the like; And the semi-solid dosage form can be an ointment, gel, paste, or the like. Dosage forms of the medicament are preferably tablets, capsules, pills and injections.

Pharmaceuticals according to one embodiment of the present invention can be prepared from existing preparations, sustained release formulations, controlled release formulations, targeting formulations, and various granule dosage formulations.

In one embodiment of the present invention, various excipients such as diluents, binders, wetting agents, disintegrants, lubricants and glidants may be used to prepare the medicaments of the present invention into tablets. The diluent may be starch, dextrin, sucrose, glucose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose, calcium sulfate, calcium hydrogen phosphate, calcium carbonate and the like; The wetting agent may be water, ethanol, isopropanol and the like; The binder may be starch pulp, dextrin, syrup, honey, glucose solution, microcrystalline cellulose, gum arabic pulp, gelatin pulp, sodium carboxymethyl cellulose and methyl cellulose; The disintegrant may be dry starch, microcrystalline cellulose, low-substituted hydroxypropylcellulose; In addition, the lubricant and lubricant may be talc, silica, stearate, liquid paraffin and the like.

Additionally, the medicament may also be coated tablets, such as dragees, film coated tablets, enteric coated tablets, and the like.

When the medicament is prepared in capsules, the active ingredient can be prepared in granules or pellets with the addition of diluents, binders and disintegrants, which are then placed in hard capsules or soft capsules.

When the medicament is prepared as an injection, the solvent may consist of water, ethanol, isopropanol, propylene glycol, or mixtures thereof. In addition, an appropriate amount of solubilizer, cosolvent, pH adjuster, osmotic pressure adjuster may be added.

In addition, colorants, preservatives, perfumes, corrigents or other additives may be added to the agent.

In one embodiment of the invention, there is provided a method of preparing the medicament, comprising the following steps:

First step: weighing Sichuan Gye 5-18, Dangsam 10-25, Safflower 13-20, Earth Dragon 12-20 and Angelica 5-15 by weight;

Second step: grinding the raw materials to obtain a powder mixture;

Third step: immersing the mixture in water for 0.5-1 hour, and then decocting the obtained for 30 minutes under heavy fire to obtain a decoction;

Fourth step: cooling the medicament and filtering with 100-250 mesh filter cloth to obtain a filtrate, and concentrating the filtrate to obtain a thick paste having a density of 1.2-1.25; And

Step 5: Drying the thick paste, grinding the dried product, and sieving to obtain the desired medicament.

In the following, some specific examples of a method of preparing a medicament for treating shoulder periarthritis are provided.

Example 1

First step: weighing Sichuan Gye 5-18, Dangsam 10-25, Safflower 13-20, Earth Dragon 12-20 and Angelica 5-15 by weight;

Second step: grinding each of the above raw materials, mixing them to obtain a mixture, immersing in water for 0.5-1 hour, and decocting the obtained at 50 ° C. for 30 minutes to obtain a decoction;

Third step: cooling the medicament for 5 hours, filtering with 100-250 mesh filter cloth to obtain a filtrate, and concentrating the filtrate to obtain a thick paste having a density of 1.2-1.25; And

Fourth step: drying the thick paste, grinding the dried product, and sieving to obtain the desired medicament.

Example 2

The first step: weighing Sichuan Gye 15, Dangsam 10, Safflower 13, Earth Dragon 18, Maengryon 20 and Angelica 12 by weight;

Second step: grinding the raw materials into fine powders, and screening them with a sieve of 100 mesh;

Third step: decoction of the screened raw material with water at 30 ° C. for 40 minutes to obtain a decoction, and allowing the decoction to stand at room temperature for 12 hours;

Fourth step: filtering the medicament with a 100-250 mesh filter cloth to obtain a filtrate, and concentrating the filtrate to obtain a thick paste; And

Step 5: Drying the thick paste, grinding the dried product, and sieving to obtain the desired medicament.

Example 3

The first step: weighing Sichuan gye 15, Dangsam 10, safflower 18, Jiryong 18, Maengryon 30, Upper limb 15 and Angelica 12 by weight;

Second step: mixing the raw materials to obtain a mixture, immersing the mixture in water, and weighing the obtained to obtain a decoction;

Third step: cooling the medicament and filtering with 100-250 mesh filter cloth to obtain a filtrate, and concentrating the filtrate to obtain a thick paste having a density of 1.2-1.25;

Fourth step: mixing the thick paste with 3-fold amount of dextrin to prepare a soft material and granulating it with an oscillating granulator to obtain granules; And

Step 5: Drying the granules at 65 ° C. for 30 minutes, performing granular straightening, screening to remove small granules, and packaging.

Example 4

The first step: weighing Sichuan gye 15, Dangsam 10, safflower 18, Jiryong 18, Maengryon 30, Upper limb 15 and Angelica 12 by weight;

Second step: mixing the raw materials to obtain a mixture, immersing the mixture in water and weighing the obtained to obtain a decoction;

Third step: cooling the medicament and filtering with 100-250 mesh filter cloth to obtain a filtrate, and concentrating the filtrate to obtain a thick paste having a density of 1.2-1.25;

Fourth step: mixing the thick paste with 3-fold of dextrin to prepare a soft material, and granulating it with a vibrating granulator to obtain granules; And

Step 5: drying the granules at 65 ° C. for 30 minutes, performing a granule calibration, tableting on a single-punch tablet press to obtain tablets weighing 0.3 g , Packaging.

A medicament for treating shoulder periarthritis according to the present invention has other ingredients compared to the medicaments of the prior art and can overcome the drawbacks of the medicaments of the prior art.

Claims (5)

By weight, including Sichuan cassia twig 5-18, Ginseng (Codonopsis pilosula) 10-25, Safflower Carthamus 13-20, Lumbricus 12-20 and Angelica sinensis 5-15 , For the treatment of shoulder periarthritis. The agent of claim 1, further comprising Radix Clematidis 20-30 by weight. The agent of claim 1, further comprising Ramulus Mori 12-18 by weight. The dosage form of claim 1, wherein the dosage form of the medicament is a film-coated tablet, dragee, enteric coated tablet, dispersible tablet, capsule, granule, decoction, mixture, syrup, medicinal wine (vinum), injection (injection), oral solution (oral solution) and oral turbid liquid (oral turbid liquid). A method for preparing a medicament according to any one of claims 1 to 4, comprising:
First step: weighing Sichuan Gye 5-18, Dangsam 10-25, Safflower 13-20, Earth Dragon 12-20 and Angelica 5-15 by weight;
Second step: grinding the raw materials to obtain a powder mixture;
Third step: immersing the mixture in water for 0.5-1 hour and decanting the resultant under a big fire for 30 minutes to obtain a prodrug;
Fourth Step: Cool the powder and filter it with 100-250 mesh filter cloth to obtain a filtrate, and concentrate the filtrate to a thick paste having a density of 1.2-1.25. Obtaining a; And
Fifth step: drying the thick paste, grinding the dried product, and sieving to obtain the desired agent.