KR20190107308A - A drug for treating gout and its preparation method - Google Patents

Abstract

The present invention relates to a medicine for treating gout and a method for manufacturing the same. The medicine for treating gout contains: 5 to 15 parts by weight of Celosia cristata; 10 to 15 parts by weight of Glechoma hederacea; 13 to 20 parts by weight of Isatidis radix; 12 to 28 parts by weight of Angelica gigas; and 5 to 12 parts by weight of Herba pyrolae. The medicine for treating gout according to the present invention has different components compared to a medicine of the prior art, and thus can overcome shortcomings of the medicine of the prior art.

Description

A drug for treating gout and its preparation method

The present invention relates to the field of drugs, in particular drugs for the treatment of gout and methods for their preparation.

Gout is a chronic metabolic disorder, a condition in which excessive uric acid is formed in the human body or urine acid excretion decreases, thereby increasing the concentration of uric acid in the blood, clinically known as hyperuricemia. Uric acid is the final product of purine metabolism, and purine is produced by catabolism of human cells. When blood uric acid is increased to some extent, it is deposited in tissues, especially joints and kidneys, causing repeated seizures of arthritis, sometimes leading to joint dyskinesia or malformations, which are clinically known as gouty arthritis. The deposition of uric acid on the kidney will cause uric acid nephrolithiasis and renal parenchymal damage, clinically known as uric acid nephropathy and gout nephropathy, which can lead to seizures of kidney colic, hematuria, hydronephrosis and renal function impairment, even kidney failure and Causes uremia, which is one of the leading causes of gout death. Because gout is a chronic lifetime disease that can last for decades and is characterized by intermittent seizures, patients suffering from gout tend to pay less attention and are not fully aware of its harm.

Currently, gout is mainly treated with medication according to clinical symptoms, and colchicine and acesodine are mainly administered to patients during gout attacks to quickly reduce inflammation and alleviate pain, while purine and the like are intermittently administered to patients with uric acid. Lower the risk of seizures once again. In general, all Western medicines currently used to treat gout have serious side effects and are only temporary. In addition, in the case of intermittent administration of Western medicine, gout can be quickly restored when drug administration is stopped, resulting in seizure of transitive gout due to excessive dissolution of uric acid.

However, the therapeutic effect of the therapy is not good. In addition, current drugs have other toxic effects. Thus, there is an urgent need for new drugs for the treatment of gout to overcome this drawback.

In view of the above problems, the present invention provides a drug for treating gout that can solve the above problems or at least some of the above problems, which is used to overcome the shortcomings of the poor therapeutic effects of the conventional drugs.

According to the first aspect, the present invention provides 5-15 parts by weight Cockscomb, 10-15 parts by weight Longhairy Antenoron Herb, 13-20 parts by Radix isatidis , Angelica sinensis 12- Provided is a gout treatment drug comprising 28 parts by weight and 5-12 parts by weight of Herba pyrolae.

Drugs for the treatment of gout of the present invention can overcome the drawbacks of the conventional drug is different in composition compared to the conventional drug.

In an embodiment of the invention, 5-15 parts by weight Cockscomb, 10-15 parts by weight Longhairy Antenoron Herb, 13-20 parts by Radix isatidis , Angelica sinensis 12-28 weight Drugs for gout treatment are provided, comprising 5-12 parts by weight of parts and Herba pyrolae.

In addition, the drug is called carapax eretmochelyos ) 20-30 parts by weight further.

In addition, the drug is Rhizoma smilacis glabrae ) 12-18 parts by weight.

The godmother and rabbinyeong are only some specific examples, but are not limited to, wolfberry fruit, Gynostemma Other materials such as pentaphyllum), 12 four won chair (12 Semen Astragali Complanati), speed (Radix dipsaci), hanryeoncho (Herba Eclipta), yeojeongja (Fructus Ligustri Lucidi) are also possible. Other possible materials will not be described in detail.

Optionally, in embodiments of the present invention, materials that promote blood circulation, such as Carcuma longa, Ligusticum chuanxiong Hort, Radix Salviae Miltiorrhizae, and Evening Primrose, may be added.

In addition, in an embodiment of the present invention, in order to improve the pharmacological effect, the drug is Gardenia (Fructus Gardeniae), Flos Chrysanthemi, Semen Cassiae, Cortex fraxini, Radix Sophorae Flavescentis, Chrysanthemum (Flos Chrysanthemi Indici), Andrographis paniculata ) and the like may further include a heat removal material.

In addition, the drug may further include a material for promoting dehumidification and diuresis, such as Herba Sedi, Abrus Herb, and the like.

In addition, the drug may further include a material that warms the interior, such as pepper.

In an embodiment of the invention, the formulation of the drug is a film-coated tablet, a sugar coated tablet, an enteric coated tablet, a dispersible tablet, a capsule, a granule, a pill, a mixture, a syrup, a binum, an injection, an oral solution and an oral turbidity. At least one of the liquids.

In an embodiment of the invention, the drug optionally has an oral-administration formulation.

In an embodiment of the invention, the oral-dose formulations optionally comprise tablets, capsules, pills, injectables, sustained release formulations and controlled release formulations.

The drug of the embodiment provided herein or the drug composition comprising the same may be administered in unit dosage form through the intestine, nasal cavity, oral mucosa, eyes, lungs, respiratory system, skin, rectum and the like, oral administration, intravenous injection, intramuscular It can be administered by injection and subcutaneous injection.

Dosage forms may be liquid dosage forms, solid dosage forms or semi-solid dosage forms. Liquid dosage forms can be solutions, emulsions, suspensions, injections (including water injections, powder injections and fluids), eye drops, non-liquid forms, lotions and applicators; Solid dosage forms include tablets (including uncoated tablets, enteric-coated tablets, oral tablets, dispersible tablets, chewable tablets, effervescent tablets, oral disintegrating tablets), capsules (hard capsules, soft capsules, enteric capsules). ), Granules, powders, pellets, drop pills, suppositories, films, pastes, aerosols, sprays, and the like; And semi-solid dosage forms can be ointments, gels, pastes and the like. Dosage formulations of the drug are preferably tablets, capsules, pills and injections.

Drugs according to embodiments of the invention can be prepared in conventional formulations, sustained release formulations, controlled release formulations, targeted formulations and various granule dosage formulations.

In an embodiment of the present invention, various excipients can be used to prepare the drug of the present invention into tablets, such as diluents, binders, moisturizers, disintegrants, lubricants and lubricants. Diluents can be starch, dextrin, sucrose, glucose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose, calcium sulfate, calcium hydrogen phosphate, calcium carbonate and the like; Humectants may be water, ethanol, isopropanol and the like; The binder may be starch meal, dextrin, syrup, honey, glucose solution, microcrystalline cellulose, gum arabic pulp, gelatin pulp, sodium carboxymethyl cellulose and methyl cellulose; Disintegrants can be dry starch, microcrystalline cellulose, lower-substituted hydroxypropyl cellulose; In addition, the lubricant and the lubricant may be talc, silica, stearate, liquid paraffin and the like.

The drug may also be coated tablets, such as sugar coated tablets, film coated tablets, enteric coated tablets, and the like.

When the drug is made into capsules, the active ingredient is made into granules or pellets by the addition of diluents, binders and disintegrants and then placed in a hard capsule or soft capsule.

When the drug is prepared as an injection, the solvent may be prepared from water, ethanol, isopropanol, propylene glycol or mixtures thereof. In addition, an appropriate amount of solubilizer, cosolvent, pH adjuster, osmotic pressure adjuster may be added.

The drug may also be added with colorants, preservatives, perfumes, taste regulators or other additives.

In an embodiment of the invention, there is provided a method of preparing said drug, comprising the following steps:

Cockscomb 5-15 parts, Longhairy Antenoron Herb 10-15 parts, Radix isatidis 13-20 parts, Angelica sinensis 12-28 parts, and Herba pyrolae ) A first step of weighing and mixing 5-12 parts by weight to obtain a mixture, and grinding the mixture;

Adding a 70% ethanol to the ground mixture in a weight ratio of 2-3: 1;

Extracting the resultant twice under reflux for 2-3 hours and filtering to obtain two filtrates; And

A fourth step of obtaining an extraction solution as a target drug formulation by mixing the two filtrates and concentrating to remove ethanol.

Hereinafter, some specific examples of the method of preparing a drug for gout treatment are provided.

Example  One

Stage 1: 5-15 parts by weight cockscomb, 10-15 parts by weight Longhairy Antenoron Herb, 13-20 parts by Radix isatidis , 12-28 parts by weight Angelica sinensis and rust Herba pyrolae ) weigh 5-12 parts by weight and mix to obtain a mixture, and ground the mixture;

Second step: mix the mixture twice with water, each adding 10 mL of water at 30 min intervals for 30 hours at 30 ° C. for 4 hours to obtain two filtrates;

Step 3: Mix the two filtrates and add 70% ethanol, where the weight of the ethanol is twice the total weight of the raw material;

Step 4: extracting the resultant under reflux twice for 2 hours each at room temperature and filtering to obtain two filtrates;

Step 5: Mix the two filtrates and concentrate to remove ethanol to obtain an extract solution as the target drug formulation.

Example  2

First step: 5 parts by weight Cockscomb, 10 parts by weight Longhairy Antenoron Herb, 13 parts by weight Radix isatidis , 28 parts by weight Angelica sinensis and 12 parts by weight Herba pyrolae Weighing;

Second step: grinding the materials into fine powder, filtering through a 200 mesh sieve and mixing uniformly to obtain a ground mixture;

Step 3: adding 70% ethanol to the ground mixture in a weight ratio of 3: 1;

Step 4: extracting the resultant twice under reflux for three hours each, and filtering to obtain two filtrates; And

Step 5: Mix the two filtrates and concentrate to remove ethanol to obtain an extract solution as the target drug formulation.

Example  3

First step: 5 parts by weight Cockscomb, 10 parts by weight Longhairy Antenoron Herb, 13 parts by weight Radix isatidis , 28 parts by weight Angelica sinensis and 12 parts by weight Herba pyrolae Weighing;

Second step: grinding the materials into fine powder, filtering through a 200 mesh sieve and mixing uniformly to obtain a ground mixture;

Step 3: adding water to the ground mixture and soaking for at least 8 hours until the mixture is completely wet;

Step 4: The mixture was poured into water twice a month, each adding 10 mL of water at 30 ° C. at 30 ° C. for 4 hours and filtering to obtain two filtrates;

Step 5: Mix the two filtrates and add 70% ethanol, where the weight of ethanol is three times the total weight of the raw material;

Step 6: extracting the resultant twice under reflux for 3 hours each and filtering to obtain two filtrates; And

Step 7: Obtain the extraction solution as the target drug formulation by mixing and concentrating the two filtrates to remove ethanol.

Drugs for the treatment of gout according to the present invention can overcome the drawbacks of the conventional drug is different in composition compared to the conventional drug.

Claims (5)

Cockscomb 5-15 parts by weight, Longhairy Antenoron Herb 10-15 parts by weight, Radix isatidis 13-20 parts by weight, Angelica sinensis 12-28 parts by weight and Herba pyrolae ) A drug for treating gout containing 5-12 parts by weight. The method of claim 1,
Godmother ( Carapax eretmochelyos ) A drug for the treatment of gout further comprising 20-30 parts by weight. The method of claim 1,
Rhizoma smilacis glabrae ) A drug for treating gout, further comprising 12-18 parts by weight. The method of claim 1,
The formulation of the drug is gout, which is at least one of film-coated tablets, sugar coated tablets, enteric coated tablets, dispersible tablets, capsules, granules, tannings, mixtures, syrups, binums, injections, oral fluids and oral suspensions Therapeutic drugs. A method for preparing a drug according to any one of claims 1 to 4, comprising the following steps:
Cockscomb 5-15 parts, Longhairy Antenoron Herb 10-15 parts, Radix isatidis 13-20 parts, Angelica sinensis 12-28 parts, and Herba pyrolae ) a first step of weighing and mixing 5-12 parts by weight to obtain a mixture, and milling the mixture;
Adding a 70% ethanol to the ground mixture in a weight ratio of 2-3: 1;
Extracting the resultant twice under reflux for 2-3 hours and filtering to obtain two filtrates; And
A fourth step of obtaining an extraction solution as a target drug formulation by mixing the two filtrates and concentrating to remove ethanol.